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https://www.readbyqxmd.com/read/27340199/sleep-disordered-breathing-impaired-cardiac-adrenergic-innervation-and-prognosis-in-heart-failure
#1
Oriana Scala, Stefania Paolillo, Roberto Formisano, Teresa Pellegrino, Giuseppe Rengo, Paola Gargiulo, Fausto De Michele, Antonio Starace, Antonio Rapacciuolo, Valentina Parisi, Maria Prastaro, Valentina Piscopo, Santo Dellegrottaglie, Dario Bruzzese, Fabiana De Martino, Antonio Parente, Dario Leosco, Bruno Trimarco, Alberto Cuocolo, Pasquale Perrone-Filardi
OBJECTIVE: Unfavourable effects of sleep-disordered breathing (SDB) in heart failure (HF) are mainly mediated by impaired sympathetic activity. Few data are available on SDB and cardiac adrenergic impairment evaluated at myocardial level. The aim of the study was to assess the relationship between SDB, cardiac sympathetic innervation assessed by (123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging and prognosis in HF. METHODS: Observational, prospective study enrolling patients with HF and reduced systolic function...
June 23, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27189470/adrenergic-drugs-blockers-or-enhancers-for-cognitive-decline-what-to-choose-for-alzheimer-s-disease-patients
#2
Grazia D Femminella, Dario Leosco, Nicola Ferrara, Giuseppe Rengo
The adrenergic system has an important role in normal central nervous system function as well as in brain disease. The locus coeruleus, the main source of norepinephrine in brain, is involved in the regulation of learning and memory, reinforcement of sleep-wake cycle and synaptic plasticity. In Alzheimer's disease, locus coeruleus degeneration is observed early in the course of the disease, years before the onset of clinical cognitive signs, with neurofibrillary detected at the stage of mild cognitive impairment, preceding amyloid deposition...
2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/26932512/myocardial-pathology-induced-by-aldosterone-is-dependent-on-non-canonical-activities-of-g-protein-coupled-receptor-kinases
#3
Alessandro Cannavo, Daniela Liccardo, Akito Eguchi, Katherine J Elliott, Christopher J Traynham, Jessica Ibetti, Satoru Eguchi, Dario Leosco, Nicola Ferrara, Giuseppe Rengo, Walter J Koch
Hyper-aldosteronism is associated with myocardial dysfunction including induction of cardiac fibrosis and maladaptive hypertrophy. Mechanisms of these cardiotoxicities are not fully understood. Here we show that mineralocorticoid receptor (MR) activation by aldosterone leads to pathological myocardial signalling mediated by mitochondrial G protein-coupled receptor kinase 2 (GRK2) pro-death activity and GRK5 pro-hypertrophic action. Moreover, these MR-dependent GRK2 and GRK5 non-canonical activities appear to involve cross-talk with the angiotensin II type-1 receptor (AT1R)...
March 2, 2016: Nature Communications
https://www.readbyqxmd.com/read/26926470/increased-epicardial-adipose-tissue-volume-correlates-with-cardiac-sympathetic-denervation-in-patients-with-heart-failure
#4
Valentina Parisi, Giuseppe Rengo, Pasquale Perrone-Filardi, Gennaro Pagano, Grazia Daniela Femminella, Stefania Paolillo, Laura Petraglia, Giuseppina Gambino, Aurelio Caruso, Maria Gabriella Grimaldi, Francesco Baldascino, Maria Nolano, Andrea Elia, Alessandro Cannavo, Antonio De Bellis, Enrico Coscioni, Teresa Pellegrino, Alberto Cuocolo, Nicola Ferrara, Dario Leosco
RATIONALE: It has been reported that epicardial adipose tissue (EAT) may affect myocardial autonomic function. OBJECTIVE: The aim of this study was to explore the relationship between EAT and cardiac sympathetic nerve activity in patients with heart failure. METHODS AND RESULTS: In 110 patients with systolic heart failure, we evaluated the correlation between echocardiographic EAT thickness and cardiac adrenergic nerve activity assessed by (123)I-metaiodobenzylguanidine ((123)I-MIBG)...
April 15, 2016: Circulation Research
https://www.readbyqxmd.com/read/26884616/prognostic-value-of-lymphocyte-g-protein-coupled-receptor-kinase-2-protein-levels-in-patients-with-heart-failure
#5
Giuseppe Rengo, Gennaro Pagano, Pasquale Perrone Filardi, Grazia Daniela Femminella, Valentina Parisi, Alessandro Cannavo, Daniela Liccardo, Klara Komici, Giuseppina Gambino, Maria Loreta D'Amico, Claudio de Lucia, Stefania Paolillo, Bruno Trimarco, Dino Franco Vitale, Nicola Ferrara, Walter J Koch, Dario Leosco
RATIONALE: Sympathetic nervous system hyperactivity is associated with poor prognosis in patients with heart failure (HF), yet routine assessment of sympathetic nervous system activation is not recommended for clinical practice. Myocardial G protein-coupled receptor kinase-2 (GRK2) is upregulated in HF patients, causing dysfunctional β-adrenergic receptor signaling. Importantly, myocardial GRK2 levels correlate with levels found in peripheral lymphocytes of HF patients. OBJECTIVE: The independent prognostic value of blood GRK2 measurements in HF patients has never been investigated; thus, the purpose of this study was to evaluate whether lymphocyte GRK2 levels predict clinical outcome in HF patients...
April 1, 2016: Circulation Research
https://www.readbyqxmd.com/read/26604244/%C3%AE-adrenergic-receptor-kinase-c-terminal-peptide-gene-therapy-improves-%C3%AE-2-adrenergic-receptor-dependent-neoangiogenesis-after-hindlimb-ischemia
#6
Alessandro Cannavo, Daniela Liccardo, Anastasios Lymperopoulos, Giuseppina Gambino, Maria Loreta D'Amico, Franco Rengo, Walter J Koch, Dario Leosco, Nicola Ferrara, Giuseppe Rengo
After hindlimb ischemia (HI), increased catecholamine levels within the ischemic muscle can cause dysregulation of β2-adrenergic receptor (β2AR) signaling, leading to reduced revascularization. Indeed, in vivo β2AR overexpression via gene therapy enhances angiogenesis in a rat model of HI. G protein-coupled receptor kinase 2 (GRK2) is a key regulator of βAR signaling, and β adrenergic receptor kinase C-terminal peptide (βARKct), a peptide inhibitor of GRK2, has been shown to prevent βAR down-regulation and to protect cardiac myocytes and stem cells from ischemic injury through restoration of β2AR protective signaling (i...
February 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/26528530/assessing-nephrological-competence-among-geriatricians-a-proof-of-concept-internet-survey
#7
Raffaele Antonelli Incalzi, Filippo Aucella, Dario Leosco, Giuliano Brunori, Michela Dalmartello, Giuseppe Paolisso
Chronic kidney disease (CKD) is highly prevalent in the elderly and negatively impacts survival and health status. Thus, nephrological competence is mandatory for a skilled geriatrician. The present study aimed to assess nephrological competence in a sample of geriatricians recruited through a web survey. To this aim, a 12-items questionnaire was produced by an expert panel of nephrologists and geriatricians and was available online for members of the Italian Society of Gerontology and Geriatrics (SIGG). Two-hundred-eighty-seven geriatricians volunteered to fill in the questionnaire...
2015: PloS One
https://www.readbyqxmd.com/read/26385799/assessment-of-the-geriatric-competence-and-perceived-needs-of-italian-nephrologists-an-internet-survey
#8
Filippo Aucella, Giuliano Brunori, Michela Dalmartello, Dario Leosco, Giuseppe Paolisso, Martino Marangella, Giovanni Battista Capasso, Raffaele Antonelli Incalzi
An internet survey was set up to assess the geriatric competence and perceived needs of 337 members of the Italian society of nephrology (SIN). The survey assessed how well aware nephrologists are of the typical geriatric conditions and needs of their elderly chronic kidney disease (CKD) patients. SIN associates were also questioned about their current use of comprehensive geriatric assessment, prescription of potentially nephrotoxic drugs, and screening for osteoporosis. The main finding is that CKD and dialysis are almost unanimously perceived as typically geriatric conditions, but knowledge and use of geriatric tools are scanty...
June 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/26091456/impact-of-an-innovative-educational-strategy-on-medication-appropriate-use-and-length-of-stay-in-elderly-patients
#9
Graziamaria Corbi, Giovanni Gambassi, Gennaro Pagano, Giusy Russomanno, Valeria Conti, Giuseppe Rengo, Dario Leosco, Roberto Bernabei, Amelia Filippelli, Nicola Ferrara
UNLABELLED: To evaluate the impact of an educational strategy on potentially inappropriate medications (PIMs) and length of stay in hospitalized elderly patients. DESIGN: An open study, with two cross-sectional surveys interspersed with an educational program (PRE phase and POST phase), has been performed in order to compare the PIMs number before and after the introduction of an educational strategy. The study included 2 phases: PRE, in which patients were enrolled as control group; POST, in which an educational strategy on the PIMs use was introduced among physicians, and patients were enrolled as intervention group...
June 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25947572/alterations-of-left-ventricular-deformation-and-cardiac-sympathetic-derangement-in-patients-with-systolic-heart-failure-a-3d-speckle-tracking-echocardiography-and-cardiac-%C3%A2-%C3%A2-%C3%A2-i-mibg-study
#10
COMPARATIVE STUDY
Dario Leosco, Valentina Parisi, Teresa Pellegrino, Gennaro Pagano, Grazia Daniela Femminella, Agnese Bevilacqua, Stefania Paolillo, Roberto Formisano, Gaetana Ferro, Claudio de Lucia, Maria Prastaro, Pasquale Perrone Filardi, Alberto Cuocolo, Giuseppe Rengo, Nicola Ferrara
PURPOSE: Myocardial contractile function is under the control of cardiac sympathetic activity. Three-dimensional speckle tracking echocardiography (3D-STE) and cardiac imaging with (123)I-metaiodobenzylguanidine ((123)I-MIBG) are two sophisticated techniques for the assessment of left ventricular (LV) deformation and sympathetic innervation, respectively, which offer important prognostic information in patients with heart failure (HF). The purpose of this investigation was to explore, in patients with systolic HF, the relationship between LV deformation assessed by 3D-STE and cardiac sympathetic derangement evaluated by (123)I-MIBG imaging...
September 2015: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/25845954/insulin-resistance-is-associated-with-impaired-cardiac-sympathetic-innervation-in-patients-with-heart-failure
#11
S Paolillo, G Rengo, T Pellegrino, R Formisano, G Pagano, P Gargiulo, G Savarese, R Carotenuto, L Petraglia, A Rapacciuolo, C Perrino, S Piscitelli, E Attena, L Del Guercio, D Leosco, B Trimarco, A Cuocolo, P Perrone-Filardi
AIMS: Insulin resistance (IR) represents, at the same time, cause and consequence of heart failure (HF) and affects prognosis in HF patients, but pathophysiological mechanisms remain unclear. Hyperinsulinemia, which characterizes IR, enhances sympathetic drive, and it can be hypothesized that IR is associated with impaired cardiac sympathetic innervation in HF. Yet, this hypothesis has never been investigated. Aim of the present observational study was to assess the relationship between IR and cardiac sympathetic innervation in non-diabetic HF patients...
October 2015: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/25819894/epicardial-adipose-tissue-has-an-increased-thickness-and-is-a-source-of-inflammatory-mediators-in-patients-with-calcific-aortic-stenosis
#12
LETTER
Valentina Parisi, Giuseppe Rengo, Gennaro Pagano, Vittoria D'Esposito, Federica Passaretti, Aurelio Caruso, Maria Gabriella Grimaldi, Tommaso Lonobile, Francesco Baldascino, Antonio De Bellis, Pietro Formisano, Nicola Ferrara, Dario Leosco
No abstract text is available yet for this article.
2015: International Journal of Cardiology
https://www.readbyqxmd.com/read/25816732/the-lipid-theory-in-the-pathogenesis-of-calcific-aortic-stenosis
#13
REVIEW
V Parisi, D Leosco, G Ferro, A Bevilacqua, G Pagano, C de Lucia, P Perrone Filardi, A Caruso, G Rengo, N Ferrara
AIMS: Biologically active phenomena, triggered by atherogenesis and inflammation, lead to aortic valve (AV) calcification. Lipids play an important role in activating the cell signaling leading to AV bone deposition. This review, based on evidence from animal and human studies, mainly focused on the involvement of lipids and atherogenic phenomena in the pathogenesis of calcific aortic stenosis (AS). DATA SYNTHESIS: The role of elevated low density lipoproteins for the risk of both vascular atherosclerosis and AS has been elucidated...
June 2015: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/25545706/impact-of-diabetes-mellitus-on-lymphocyte-grk2-protein-levels-in-patients-with-heart-failure
#14
MULTICENTER STUDY
Giuseppe Rengo, Gennaro Pagano, Stefania Paolillo, Claudio de Lucia, Grazia D Femminella, Daniela Liccardo, Alessandro Cannavo, Roberto Formisano, Laura Petraglia, Klara Komici, Franco Rengo, Bruno Trimarco, Nicola Ferrara, Dario Leosco, Pasquale Perrone-Filardi
BACKGROUND: Diabetes mellitus (DM) is associated with impaired prognosis in patients with heart failure (HF), but pathogenic mechanisms are unclear. In the failing heart, elevated β-adrenergic receptor (β-AR) activation by catecholamines causes G-protein-coupled receptor kinase-2 (GRK2) upregulation which is responsible for β-AR signalling dysfunction. Importantly, GRK2 expression, measured in peripheral lymphocytes of HF patients, correlates with levels of this kinase in the failing myocardium reflecting the loss of hemodynamic function...
February 2015: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/25508788/early-start-exercise-training-after-acute-hemodynamic-decompensation-in-patients-with-chronic-heart-failure-re-start-a-multicenter-randomized-controlled-trial-on-short-term-feasibility-and-impact-on-functional-capacity-symptoms-and-neurohumoral-activation
#15
Alessandro Mezzani, Francesco Cacciatore, Raffaella Catanzaro, Alessandra Gualco, Daniela Guzzetti, Dario Leosco, Mauro Monelli, Franco Tarro Genta, Paolo Totaro, Egidio Traversi, Emanuela Zanelli, Pantaleo Giannuzzi
RE-START is a multicenter, randomized, prospective, open, controlled trial aiming to evaluate the feasibility and the short- and medium-term effects of an early-start AET program on functional capacity, symptoms and neurohormonal activation in chronic heart failure (CHF) patients with recent acute hemodynamic decompensation. Study endpoints will be: 1) safety of and compliance to AET; 2) effects of AET on i) functional capacity, ii) patient-reported symptoms and iii) AET-induced changes in beta-adrenergic receptor signaling and circulating angiogenetic and inflammatory markers...
March 2014: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/25481936/early-start-exercise-training-after-acute-hemodynamic-decompensation-in-patients-with-chronic-heart-failure-re-start-a-multicenter-randomized-controlled-trial-on-short-term-feasibility-and-impact-on-functional-capacity-symptoms-and-neurohumoral-activation
#16
RANDOMIZED CONTROLLED TRIAL
Alessandro Mezzani, Francesco Cacciatore, Raffaella Catanzaro, Alessandra Gualco, Daniela Guzzetti, Dario Leosco, Mauro Monelli, Franco Tarro Genta, Paolo Totaro, Egidio Traversi, Emanuela Zanelli, Pantaleo Giannuzzi
RE-START is a multicenter, randomized, prospective, open, controlled trial aiming to evaluate the feasibility and the short- and medium-term effects of an early-start AET program on functional capacity, symptoms and neurohormonal activation in chronic heart failure (CHF) patients with recent acute hemodynamic decompensation. Study endpoints will be: 1) safety of and compliance to AET; 2) effects of AET on i) functional capacity, ii) patient-reported symptoms and iii) AET-induced changes in beta-adrenergic receptor signaling and circulating angiogenetic and inflammatory markers...
March 2014: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/25071591/adrenal-adrenoceptors-in-heart-failure
#17
REVIEW
Claudio de Lucia, Grazia D Femminella, Giuseppina Gambino, Gennaro Pagano, Elena Allocca, Carlo Rengo, Candida Silvestri, Dario Leosco, Nicola Ferrara, Giuseppe Rengo
Heart failure (HF) is a chronic clinical syndrome characterized by the reduction in left ventricular (LV) function and it represents one of the most important causes of morbidity and mortality worldwide. Despite considerable advances in pharmacological treatment, HF represents a severe clinical and social burden. Sympathetic outflow, characterized by increased circulating catecholamines (CA) biosynthesis and secretion, is peculiar in HF and sympatholytic treatments (as β-blockers) are presently being used for the treatment of this disease...
2014: Frontiers in Physiology
https://www.readbyqxmd.com/read/24952928/reperfusion-correlates-and-clinical-outcomes-of-right-ventricular-dysfunction-in-patients-with-inferior-st-segment-elevation-myocardial-infarction-undergoing-percutaneous-coronary-intervention
#18
Raffaele Piccolo, Tullio Niglio, Letizia Spinelli, Ernesto Capuano, Teresa Strisciuglio, Carolina D'Anna, Stefania De Luca, Dario Leosco, Antonio Rapacciuolo, Plinio Cirillo, Eugenio Stabile, Giovanni Esposito, Bruno Trimarco, Federico Piscione, Gennaro Galasso
We evaluated the relation between reperfusion indexes and right ventricular (RV) dysfunction in patients with inferior ST-segment elevation myocardial infarction (STEMI). We included patients with inferior STEMI undergoing percutaneous coronary intervention and right coronary artery as infarct-related artery. Myocardial reperfusion was evaluated by Thrombolysis In Myocardial Infarction (TIMI) flow, TIMI frame count, myocardial blush grade, and ST-segment resolution. RV dysfunction was defined as tricuspid annular plane systolic excursion≤16 mm in M-mode imaging...
July 15, 2014: American Journal of Cardiology
https://www.readbyqxmd.com/read/24898649/autonomic-dysfunction-in-alzheimer-s-disease-tools-for-assessment-and-review-of-the-literature
#19
REVIEW
Grazia Daniela Femminella, Giuseppe Rengo, Klara Komici, Paola Iacotucci, Laura Petraglia, Gennaro Pagano, Claudio de Lucia, Vincenzo Canonico, Domenico Bonaduce, Dario Leosco, Nicola Ferrara
Autonomic dysfunction is very common in patients with dementia, and its presence might also help in differential diagnosis among dementia subtypes. Various central nervous system structures affected in Alzheimer's disease are also implicated in autonomic nervous system regulation, and it has been hypothesized that the deficit in central cholinergic function observed in Alzheimer's disease could likely lead to autonomic dysfunction. Several feasible tests can be used in clinical practice for the assessment of parasympathetic and sympathetic functions, especially in terms of cardiovascular autonomic modulation...
2014: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/24720923/changes-of-natriuretic-peptides-predict-hospital-admissions-in-patients-with-chronic-heart-failure-a-meta-analysis
#20
REVIEW
Gianluigi Savarese, Francesca Musella, Carmen D'Amore, Enrico Vassallo, Teresa Losco, Francesco Gambardella, Milena Cecere, Laura Petraglia, Gennaro Pagano, Luigi Fimiani, Giuseppe Rengo, Dario Leosco, Bruno Trimarco, Pasquale Perrone-Filardi
OBJECTIVES: The goal of this study was to explore the association between changes in B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) plasma levels and risk of hospital admission for heart failure (HF) worsening in patients with chronic HF. BACKGROUND: The relationship between BNP and NT-proBNP plasma levels and risk of cardiovascular events in patients with chronic HF has been previously demonstrated. However, it is unclear whether changes in BNP and NT-proBNP levels predict morbidity in patients with chronic HF...
April 2014: JACC. Heart Failure
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