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Testosterone and Increases

Louise M Emmett, Charlotte Yin, Megan Crumbaker, George Hruby, Andrew Kneebone, Richard Epstein, Quco Nguyen, Adam Hickey, Noah Ihsheish, Gordon O'Neill, Lisa Hovarth, Venu Chalasani, Phillip Stricker, Anthony Joshua
Prostate specific membrane antigen (PSMA) may be targeted for both diagnostic and therapeutic purposes in the management of prostate cancer (PCa). In pre-clinical models, androgen blockade (AB) increases expression of PSMA in both hormone sensitive and castrate resistant xenotypes. The aim of this study was to evaluate the effect of AB treatment on Ga68PSMA-11 PET imaging in hormone naive (Luteinising hormone-releasing hormone (LHRH) ± bicalutamide), and in castrate resistant men (enzalutamide or abiraterone) with metastatic PCa...
December 14, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Marina L Câmara, Talita B Almeida, Fabiane de Santi, Beatriz M Rodrigues, Paulo S Cerri, Flávia L Beltrame, Estela Sasso-Cerri
The selective serotonin reuptake inhibitor fluoxetine has been used for the treatment of depression. Although sexual disorders have been reported in male patients, few studies have demonstrated the fluoxetine effect on the reproductive histophysiology, and the target of this antidepressant in testes is unknown. We evaluated the impact of short-term treatment with fluoxetine on the adult rat testes, focusing on steroidogenesis by Leydig cells (LC) and androgen-dependent testicular parameters, including Sertoli cells (SC) and peritubular myoid cells (PMC)...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sarika Chaudhari, Spencer C Cushen, Oluwatobiloba Osikoya, Paresh A Jaini, Rachel Posey, Keisa W Mathis, Styliani Goulopoulou
Epidemiological studies demonstrate disparities between men and women in cardiovascular disease prevalence, clinical symptoms, treatments, and outcomes. Enrollment of women in clinical trials is lower than men, and experimental studies investigating molecular mechanisms and efficacy of certain therapeutics in cardiovascular disease have been primarily conducted in male animals. These practices bias data interpretation and limit the implication of research findings in female clinical populations. This review will focus on the biological origins of sex differences in cardiovascular physiology, health, and disease, with an emphasis on the sex hormones, estrogen and testosterone...
December 13, 2018: Comprehensive Physiology
Soulmaz Shorakae, Eveline Jona, Barbora de Courten, Gavin W Lambert, Elisabeth A Lambert, Sarah E Phillips, Iain J Clarke, Helena J Teede, Belinda A Henry
OBJECTIVE: Polycystic ovary syndrome (PCOS) is associated with increased obesity with a greater propensity to weight gain and a lack of sustainable lifestyle interventions. Altered brown adipose tissue (BAT) thermogenesis is a potential contributor to obesity in PCOS. BAT activity and modulation has not been studied in PCOS. This observational study explored BAT thermogenesis and its associations in women with and without PCOS. PARTICIPANTS AND METHODS: Cutaneous temperature was recorded from supraclavicular (indicator of BAT activity) and upper arm regions using Dataloggers (SubCue, Calgary, Canada) in a cross sectional sub-study, nested within a randomized control trial, of community recruited pre-menopausal women with (n=47, Rotterdam diagnostic criteria) and without (n=11) PCOS...
December 12, 2018: Clinical Endocrinology
Tsuyoshi Suzuki, Sandra Palus, Jochen Springer
Patients suffering from chronic heart failure (CHF) show an increased prevalence (~20% in elderly CHF patients) of loss of muscle mass and muscle function (i.e. sarcopenia) compared with healthy elderly people. Sarcopenia, which can also occur in obese patients, is considered a strong predictor of frailty, disability, and mortality in older persons and is present in 5-13% of elderly persons aged 60-70 years and up to 50% of all octogenarians. In a CHF study, sarcopenia was associated with lower strength, reduced peak oxygen consumption (peak VO2 , 1173 ± 433 vs...
December 7, 2018: ESC Heart Failure
Attia Abd Allah Attia, Mohamed Abd El Mawgood Amer, Mamdouh Hassan, Sameh Fayek GamalEl Din
PURPOSE: The purpose of the study was to compare serum level of folic acid (FA) in patients with erectile dysfunction (ED) versus healthy controls and to assess its correlation with other well-known confounders for ED. METHODS: Our prospective study compared FA in 60 patients with ED versus 30 healthy controls. Patients were excluded if they had any hormonal disorders, Peyronie's disease, or decompensated systemic illnesses. ED was evaluated by the validated Arabic version of the abbreviated five-item form of the International Index Of Erectile Function and confirmed by penile duplex...
December 13, 2018: International Urology and Nephrology
Ghulam Nabi, Yujiang Hao, Richard William McLaughlin, Ding Wang
Background: Poyang is the largest freshwater lake in China, where the acoustic environment and space for the critically endangered Yangtze finless porpoises (YFPs) has been altered by heavy vessel traffic and dredging activities. The density of vessel and the rate of dredging increases annually, especially in the area with the highest density of YFPs. The heavy vessel traffic can cause an increase in the physical activities and direct physical injuries to the YFPs. Furthermore, noise is a potent stressor to all cetaceans irrespective of age and can compromise all their physiological functions...
2018: Frontiers in Physiology
Juan Mielgo-Ayuso, Julio Calleja-González, Aritz Urdampilleta, Patxi León-Guereño, Alfredo Córdova, Alberto Caballero-García, Diego Fernandez-Lázaro
INTRODUCTION: Deficient levels of 25-hydroxyvitamin D (25(OH)D) (<30 ng/mL) may compromise health and athletic performance. Supplementation with oral vitamin D can favor the state of iron metabolism, and testosterone and cortisol as an indicator of muscle recovery of the athlete with a deficiency. The main aim of this study was to evaluate the influence of eight weeks of supplementation with 3000 IU/day of vitamin D on the hematological and iron metabolism profile, as well as on the analytical values of testosterone and cortisol on elite male traditional rowers...
December 12, 2018: Nutrients
Rafa S Almeer, Doaa Soliman, Rami B Kassab, Gadah I AlBasher, Saud Alarifi, Saad Alkahtani, Daoud Ali, Dina Metwally, Ahmed E Abdel Moneim
The current study examined the efficacy of royal jelly (RJ) against cadmium chloride (CdCl₂)-induced testicular dysfunction. A total of 28 Swiss male mice were allocated into four groups (n = 7), and are listed as follows: (1) the control group, who was intraperitoneally injected with physiological saline (0.9% NaCl) for 7 days; (2) the RJ group, who was orally supplemented with RJ (85 mg/kg daily equivalent to 250 mg crude RJ) for 7 days; (3) the CdCl₂ group, who was intraperitoneally injected with 6.5 mg/kg for 7 days; and (4) the fourth group, who was supplemented with RJ 1 h before CdCl₂ injection for 7 days...
December 10, 2018: International Journal of Molecular Sciences
Seonung Lim, Wonwoo Lee, Doo Suk Lee, In-Jeong Nam, Nayoung Yun, Yoonseon Jeong, Taewoong Rho, Sunyoung Kim
Benign prostatic hyperplasia (BPH) is a common disease in the elderly male population throughout the world. Among other factors, androgen dysregulation has been known to play major roles in its pathogenesis. HX109 is a botanical formulation prepared from a mixture of Taraxacum officinale , Cuscuta australis , and Nelumbo nucifera , which have traditionally been used-usually along with other plants-to treat urinary diseases. An ethanol extract was prepared from a mixture of these three plants, and its quality was controlled through cell-based bioassays and by quantification of several marker compounds by high-performance liquid chromatography (HPLC)...
December 7, 2018: Nutrients
Hiroyuki Fukami, Taro Ueda, Nobuya Matsuoka
Compound K (CK) is a metabolite of a saponin in Panax ginseng, formed from ginsenoside, a triterpenoid glycoside, by human intestinal bacteria. Lactobacillus paracasei A221 isolated from fermented food can hydrolyze (deglycosylate) the main ginsenoside, ginsenoside Rb1, and generate CK. However, the pharmacokinetics of L. paracasei A221 fermented ginseng (FG) and nonfermented ginseng (NFG) have not been investigated so far. The aim of this study was to investigate the pharmacokinetics of CK after oral administration of single doses of FG and NFG in healthy Japanese adults...
December 13, 2018: Journal of Medicinal Food
Cuiling Zhu, Yi Zhang, Ling Zhang, Jingyang Gao, Fangyun Mei, Bing Zhu, Liesheng Lu, Donglei Zhou, Shen Qu
BACKGROUND: To examine changes in sex hormones after laparoscopic sleeve gastrectomy (LSG) in Chinese obese male patients and their correlation with metabolic parameters including serum uric acid (SUA) METHODS: A total of 56 obese men with body mass index (BMI) 41.9 ± 5.8 kg/m2 undergoing LSG were selected. Thirty-one healthy men with normal BMI were included as controls. Levels of total testosterone (TT), estradiol (E2), sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH), luteinizing hormone (LH), SUA, and other metabolic indices were compared pre- and 12 months post-LSG...
December 12, 2018: Obesity Surgery
Xinchen Wu, Mengqi Zhang
Osteoporosis is liable to affect patients with gonadal hormone deficiency, and a supplement of androgens may be used to increase bone density of patients with osteoporosis. Since the androgens currently used may cause severe side effects, it is useful to investigate the effect of other androgens and progestin on bone improvement. The aim of the current study was to investigate the effects of pregnenolone (Preg), androstenedione (AD), etiocholanolone (Etio), androsterone (An), nandrolone (NA) and testosterone (T) on the proliferation and differentiation of osteoblasts for potential clinical applications...
December 2018: Experimental and Therapeutic Medicine
André M Londe, Moacir Marocolo, Isabela Coelho Marocolo, James Fisher, Octavio Barbosa Neto, Markus Vinicius Campos Souza, Gustavo Ribeiro da Mota
Perception of red color is associated with higher testosterone concentration and better human performance. Thus, we evaluated the acute effects of wearing colored-lens glasses on the YoYo intermittent endurance exercise test 2 (YoYoIE2) performance indicators and testosterone concentration. Ten soccer players performed three YoYoIE2 (counterbalanced crossover) wearing colorless (control), blue- or red-lensed glasses (2-4 days of rest in between). YoYoIE2 performance did not differ among the trials ( p >0...
April 2018: Sports medicine international open
Teuku Armansyah, Edi Rusmansyah Putra Barat, Cut Vela Risqa Handini, Dwinna Aliza, Amalia Sutriana, Hamdan Hamdan, Budianto Panjaitan, Arman Sayuti, Tongku Nizwan Siregar
This study aimed to determine the effect of seminal vesicle extract administration to increase the concentration and motility of spermatozoa and testosterone level of kacang goat. The experiment was arranged using a randomly completely block design (RCBD). Three kacang goats were used and each goat received three treatments namely P0 (2 mL of 0.9% NaCl), P1 (1.5 mL Capriglandin, PGF2α), and P2 (2 mL of seminal vesicle extract, EVS). Semen and blood were collected two days post-treatment to measure the concentration and motility of spermatozoa and testosterone level...
2018: Open Veterinary Journal
Z Esmaeilinezhad, S Babajafari, Z Sohrabi, M-H Eskandari, S Amooee, R Barati-Boldaji
BACKGROUND AND AIMS: Polycystic Ovarian Syndrome is a common reproductive, endocrine, and metabolic disease in women. Pomegranate juice, known as a rich source of phytochemicals with high antioxidant activity, enriched with probiotic may improve PCOS. METHODS AND RESULTS: A randomized, controlled, triple-blinded, parallel trial study was performed in PCOS patients (n = 92). Three treatment groups (23 patients each) received 2 L of synbiotic pomegranate juice (SPJ), pomegranate juice (PJ), and synbiotic beverage (SB) weekly...
July 17, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
P Sansone, A Tessitore, H Paulauskas, I Lukonaitiene, H Tschan, V Pliauga, D Conte
OBJECTIVES: To evaluate external and internal training load (TL) and hormonal responses in basketball 3-versus-3 small-sided games (SSGs). DESIGN: Randomized repeated-measures study. METHODS: Twelve male basketball players participated to four 3-versus-3 SSGs characterized by different tactical tasks (offensive; defensive) and training regimes (long-intermittent: three 4-min bouts with 2' rest in between; short-intermittent: six 2-min bouts with 1' rest in between)...
November 23, 2018: Journal of Science and Medicine in Sport
Dariyush Raeisi, Mohammad Erfan Zare, Atefeh Nasir, Hamidraza Sherkatolabbasieh, Shiva Shafeizadeh
Pathogenesis of systemic lupus erythematosus (SLE) is complex and multi-factorial. Among various suggested mechanisms for the disease, the hormonal theory has been considered as one of the most important mechanisms. Recently, the association of sex hormones with manifestations of antiphospholipid antibody syndrome (APLS) has been hypothesized. The aim of present study was to assess the serum levels of anticardiolipin antibody (ACA), sex hormones and prolactin in SLE female patients and their association with the disease...
August 12, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Stella A Nagel, Michaela F Hartmann, Felix G Riepe, Stefan A Wudy, Martin Wabitsch
BACKGROUND/AIMS: Mutations in the DAX1 gene cause X-linked adrenal hypoplasia congenita (AHC) classically associated with hypogonadotropic hypogonadism. Unexpectedly, precocious puberty (PP) has been reported in some cases, its mechanism remaining unclear. METHODS: We longitudinally studied a boy with AHC due to DAX1 gene mutation who developed peripheral PP at age 4.5 years. Initially he presented pubic hair, penile enlargement, advanced bone age and elevated testosterone levels...
December 11, 2018: Hormone Research in Pædiatrics
Verica Milivojevic, Jonathan Covault, Gustavo A Angarita, Kristen Siedlarz, Rajita Sinha
BACKGROUND AND OBJECTIVES: Neuroactive steroids (NAS) may play a role in addiction, with observed increases in response to acute stress and drug use, but decreases with chronic substance use, suggesting that NAS neuroadaptations may occur with chronic substance use. However, levels of NAS in addicted individuals have not been systematically examined. Here, we evaluated a panel of NAS in men and women with cocaine use disorder (CUD) who participated in a clinical laboratory study of progesterone...
December 11, 2018: American Journal on Addictions
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