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Testosterone and Increases

Brian M Bird, Shawn N Geniole, Tanya L Procyshyn, Triana L Ortiz, Justin M Carré, Neil V Watson
The social heuristic hypothesis posits that human cooperation is an intuitive response that is expressed especially under conditions of time-constraint. Conversely, it proposes that for individuals given an opportunity for reflection, cooperation is more likely to be curtailed by an optimizing process calibrated to maximize individual benefit in a given situation. Notably, the steroid hormone testosterone has also been implicated in intuitive decision-making, including both prosocial and anti-social behaviors, with effects strongest in men with particular dispositional characteristics...
September 19, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Iris I Levin, Bailey K Fosdick, Toshi Tsunekage, Matthew A Aberle, Christine M Bergeon Burns, Amanda K Hund, Rebecca J Safran
Animals use morphological signals such as ornamental traits or weaponry to mediate social interactions, and the extent of signal trait elaboration is often positively associated with reproductive success. By demonstrating relationships between signal traits and fitness, researchers often make inferences about how behaviour operates to shape those outcomes. However, detailed information about fine-scale individual behaviour, and its physiological basis, can be difficult to obtain. Here we show that experimental manipulations to exaggerate a signal trait (plumage colour) and concomitant changes in testosterone and stress-induced corticosterone levels altered social interactivity between manipulated males and their social mates...
October 19, 2018: Scientific Reports
Lei Dou, Yahong Zheng, Lu Li, Xiaowei Gui, Yajuan Chen, Meng Yu, Yi Guo
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most prevalent cause of anovulatory infertility and hyperandrogenism. Evidence favors insulin resistance and compensatory hyperinsulinemia as the predominant, perhaps primary, defects in PCOS. The use of insulin-sensitizing drugs has been shown to improve both the reproductive and the metabolic aspects of PCOS. Cinnamon has been found to have insulin sensitizing effect and improve menstrual cyclicity in women with PCOS. The aim of this study was to determine the effect and mechanism of cinnamon on PCOS using a dehydroepiandrosterone (DHEA) induced PCOS mouse model...
October 19, 2018: Reproductive Biology and Endocrinology: RB&E
Katie B Needham, Christy Bergeon Burns, Jessica L Graham, Carolyn M Bauer, Jeffrey D Kittilson, Ellen D Ketterson, Thomas Hahn, Timothy J Greives
Mechanisms related to seasonal reproductive timing in vertebrates have received far more study in males than in females, despite the fact that female timing decisions dictate when rearing of offspring will occur. Production and release of gonadotropin-releasing hormone (GnRH) by the hypothalamus stimulates the pituitary to secrete gonadotropins, initiating the beginning stages of gonadal recrudescence and production of the sex steroids, testosterone and estradiol, which are necessary to prime the liver for secretion of yolk precursors in breeding female birds...
October 16, 2018: General and Comparative Endocrinology
S S Lim, N S Kakoly, J W J Tan, G Fitzgerald, M Bahri Khomami, A E Joham, S D Cooray, M L Misso, R J Norman, C L Harrison, S Ranasinha, H J Teede, L J Moran
Women with polycystic ovary syndrome (PCOS) have increased risk of metabolic syndrome. The relative contribution of clinical, demographic or biochemical factors to metabolic syndrome in PCOS is not known. A literature search was conducted in MEDLINE, CINAHL, EMBASE and clinical trial registries. Of 4530 studies reviewed, 59 were included in the systematic review and 27 in the meta-analysis and meta-regression. In good and fair quality studies, women with PCOS had an overall increased prevalence of metabolic syndrome (odds ratio, OR 3...
October 19, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Anuradha Batabyal, Maria Thaker
Animals engage in social interactions with changes in their behaviour and physiology. Environmental challenges, however, can influence social interactions by adding additional stressors. Here, we investigated the effects of urbanisation on the behaviour and hormonal responses of a tropical lizard species, Psammophilus dorsalis, during social interactions. We recorded behaviour of males from suburban and rural areas during controlled encounters with other males and females. We then measured corticosterone and testosterone levels of individuals at 10 min intervals, from immediately after the social encounter to 30 min later and then at 120 min after the interaction period...
October 15, 2018: General and Comparative Endocrinology
Burcin Erkal, Aysel Kalayci Yigin, Sukru Palanduz, Selcuk Dasdemir, Mehmet Seven
Klinefelter syndrome (KS) is a common sex chromosome-related abnormality seen among men. KS negatively affects spermatogenesis and testosterone production. It increases the risk of thrombosis but its molecular mechanism has not been well described yet. Elevated PAI-1 is a risk factor for thrombosis. The rs1799889 polymorphism located in the promoter region of the PAI-1 gene was detected in patients with deep venous thrombosis. In this study, the PAI-1 gene variant and its plasma levels in KS patients were examined...
November 2018: American Journal of Men's Health
Hassan Hassani-Bafrani, Hamed Najaran, Mazdak Razi, Hamid Rashtbari
The present study was performed to show the ameliorative effect of berberine (BBR), as an antioxidant and anti-inflammatory agent, against experimental varicocele (VCL)-induced molecular and histological damages. For this purpose, 50 mature Wistar rats were divided into control, control-sham, VCL-sole, 50 mg/kg and 100 mg/kg BBR-treated VCL-induced groups. The tissue levels of interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), nitric oxide (NO), total antioxidant capacity (TAC), malondialdehyde (MDA), superoxide dismutase (SOD) and gluthatione peroxidase (GSH-px) as well as the mRNA levels of testicular CuZn SOD, MnSOD, EC-SOD and GSH-px were evaluated...
October 17, 2018: Andrologia
Hikmat Permana, Guntur Darmawan, Ervita Ritonga, Maya Kusumawati, Miftahurachman Miftahurachman, Nanny Natalia Soetedjo
Adrenocortical carcinoma (ACC) is a rare solid tumor with an incidence of 0.5 to 2 cases per million per year. It affects women more commonly than men with a ratio of 1.5:1. Ectopic ACC are considered to be extremely rare with no exact incidence data yet. We report an interesting case of hepatic ACC in a young woman with clinical signs of virilization.A-21-year old Sundanese woman visited our endocrine clinic with progressive hirsutism over the face, body, and extremities starting 14 years previously. She had irregular, heavy periods when she was 7 years old...
July 2018: Acta Medica Indonesiana
Ana Cláudia Ferreira Souza, Felipe Couto Santos, Daniel Silva Sena Bastos, Marcela Nascimento Sertorio, João Paulo Gusmão Teixeira, Kenner Morais Fernandes, Mariana Machado-Neves
Reproductive seasonality in Neotropical bats has been assessed to the better understand their reproductive behavior. This knowledge is especially important for the control of Desmodus rotundus population as it is a transmitter of rabies virus. Therefore, we aimed to evaluate the functional activity of testis and epididymis of D. rotundus in dry and rainy seasons under a morphological approach. We observed an increase in tubular diameter and epithelial height of the seminiferous tubules during the rainy season...
2018: PloS One
Jasna Aleksova, Alexander J Rodriguez, Robert McLachlan, Peter Kerr, Frances Milat, Peter R Ebeling
PURPOSE OF REVIEW: Patients with chronic kidney disease (CKD) have a greatly increased fracture risk compared with the general population. Gonadal hormones have an important influence on bone mineral density (BMD) and fracture risk, and hormone therapies can significantly improve these outcomes. Gonadal dysfunction is a frequent finding in patients with CKD; yet, little is known about the impact of gonadal hormones in the pathogenesis and treatment of bone health in patients with CKD...
October 17, 2018: Current Osteoporosis Reports
Lihua Yao, Mingyang Li, Jingwen Hu, Wangsheng Wang, Minzhi Gao
Polycystic ovary syndrome (PCOS) is a major cause of infertility in women of reproductive age. However, its exact etiology remains unknown. In this study, we sequenced miRNAs in human follicular fluid and identified 16 downregulated and 3 upregulated miRNAs in PCOS group compared with non-PCOS group. Among the differential expressed miRNAs, miR-335-5p was verified lower abundance in PCOS than non-PCOS group using quantitative real-time PCR. Besides, miR-335-5p negatively correlated with antral follicle count, anti-Müllerian hormone and total testosterone...
September 4, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Jorge L Alves-Pereira, Eliete Dalla Corte Frantz, Lucas Alves Sarmento Pires, Marcio Antonio Babinski, Cristiane da Fonte Ramos
Erectile dysfunction is a common condition that affects men over age 40. It is highly related to obesity. The corpus cavernosum is the most important structure involved in erection. The aim of this study was to evaluate the structure of the corpus cavernosum of mice fed with a high energy density diet (HED). At 3 months of age, male C57BL/6 mice were fed with a HED diet (50% lipids) or standard chow (SC) diet (10% lipids) for 14 weeks. Afterwards, the animals were euthanized and the corpus cavernosum was analyzed through stereology...
October 16, 2018: International Journal of Impotence Research
Kelsie A Miller, Linas W Kenter, Timothy S Breton, David L Berlinsky
Sex differentiation in many lower vertebrates (e.g. reptiles, amphibians, and fishes) can be influenced by environmental factors experienced during sensitive developmental periods. Environmental stressors, acting through cortisol, masculinize some teleost fishes during development by limiting gonadal cytochrome P450 aromatase (cyp19a1a), the enzyme that irreversibly converts testosterone to 17β-estradiol. In this study, we examined the influence of cortisol, cortisol inhibitors and a repeated, acute stressor (net-chasing) on sex differentiation in black sea bass (BSB; Centropristis striata), a protogynous hermaphroditic teleost...
October 13, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
Thiago Gagliano-Jucá, Karol M Pencina, Tomas Ganz, Thomas G Travison, Philip W Kantoff, Paul L Nguyen, Mary-Ellen Taplin, Adam S Kibel, Zhuoying Li, Grace Huang, Robert R Edwards, Elizabeta Nemeth, Shehzad Basaria
Androgen deprivation therapy (ADT) is a mainstay of treatment for prostate cancer (PCa). As androgens stimulate erythropoiesis, ADT is associated with a reduction in hematocrit, which in turn contributes to fatigue and related morbidity. However, the mechanisms involved in ADT-induced reduction in erythropoiesis remain unclear. We conducted a 6-month prospective cohort study and enrolled men with PCa about to undergo ADT (ADT-Group) and a control group of men who had previously undergone prostatectomy for localized PCa and were in remission (Non-ADT Group)...
October 16, 2018: American Journal of Physiology. Endocrinology and Metabolism
Sathish Kumar, Geoffrey H Gordon, David H Abbott, Jay S Mishra
Adequate maternal vascular adaptations and blood supply to the uterus and placenta are crucial for optimal oxygen and nutrient transport to growing fetuses of eutherian mammals, including humans. Multiple factors contribute to hemodynamics and structuring of placental vasculature essential for term pregnancy with minimal complications. In women, failure to achieve or sustain favorable pregnancy progression is, not surprisingly, associated with high incidence of antenatal complications, including preeclampsia, a hypertensive disorder of pregnancy...
October 16, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Hyun Hwangbo, Da He Kwon, Eun Ok Choi, Min Yeong Kim, Kyu Im Ahn, Seon Yeong Ji, Jong Sik Kim, Kyung-Il Kim, No-Jin Park, Bum Hoi Kim, Gi-Young Kim, Su-Hyun Hong, Cheol Park, Ji-Suk Jeong, Yung Hyun Choi
BACKGROUND/OBJECTIVES: Benign prostatic hypertrophy (BPH) is a major cause of abnormal overgrowth of the prostate mainly in the elderly. Corni Fructus has been reported to be effective in the prevention and treatment of various diseases because of its strong antioxidant effect, but its efficacy against BPH is not yet known. This study was designed to evaluate the therapeutic efficacy of Corni Fructus water extract (CF) in testosterone-induced BPH rats. MATERIALS/METHODS: To induce BPH, rats were intraperitoneal injected with testosterone propionate (TP)...
October 2018: Nutrition Research and Practice
Bo-Ram Jin, Hyo-Jung Kim, Sang-Kyun Park, Myoung-Seok Kim, Kwang-Ho Lee, Il-Joo Yoon, Hyo-Jin An
Benign prostatic hyperplasia (BPH), an age-dependent disorder with a prevalence percentage of 60% in the 60s, has been found to involve an androgenic hormone imbalance that causes confusion between cell apoptosis and proliferation. Because general medications for BPH treatment have undesirable side effects, the development of effective alternative medicines has been considered. HBX-5 is a newly developed formula with the aim of improving BPH, and is composed of nine medicinal herbs. BPH was induced in the rats by intramuscular injection of testosterone propionate after castration...
October 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Luciele Guerra Minuzzi, Luis Rama, Matheus Uba Chupel, Fátima Rosado, Gabriel Keine Kuga, Rafael Calais Gaspar, Vitor Rosetto Muñoz, José Rodrigo Pauli, Artur Paiva, Ana Maria Teixeira
The purpose of this study was to investigate the impact of a training season (approximately 7 months) on physiological and salivary immune-endocrine markers in master athletes. Nine male master athletes were evaluated at the beginning of the season (M1) and a week after the main official competition at the end of the sports season (M2). The controlled variables included Maximal oxygen consumption, anthropometric, physiological, and salivary immune-endocrine markers. Master athletes presented a reduced percentage of fat mass and increased lean body mass at the end of the season...
October 15, 2018: Journal of Cellular Biochemistry
Mauricio Castro-Sepulveda, Rodrigo Ramirez-Campillo, Felipe Abad-Colil, Camila Monje, Luis Peñailillo, Jorge Cancino, Hermann Zbinden-Foncea
A soccer match induce changes in physiological stress biomarkers as testosterone (T), cortisol (C), and testosterone:cortisol (T:C) ration. Hydration state may also modulate these hormones, and therefore may alter the anabolic/catabolic balance in response to soccer match. The role of hydration status before the match in this biomarkers has not yet been reported. The aim of this study was to compare the salivary T, C, and the T:C ratio responses after two friendly matches in well-hydrated and mild-dehydrated (MD) elite young male soccer player...
2018: Frontiers in Physiology
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