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Testosterone and Increases

M Johnson, A Raheem, F De Luca, M Hallerstrom, Y Zainal, S Poselay, B Mohammadi, A Moubasher, T F Johnson, A Muneer, P Sangster, D J Ralph
OBJECTIVE: To describe the prevalence of Y-chromosome microdeletions in a multi-ethnic urban population in London, UK. To also determine predictive factors and a clinical threshold for genetic testing in men with Y chromosome microdeletions. DESIGN: A retrospective cohort study of 1473 men that were referred to a tertiary Andrology centre with male factor infertility between July 2004 and December 2016. All had a genetic evaluation, hormonal profile and 2 abnormal semen analyses...
August 16, 2018: BJU International
Watcharaporn Preedapirom, Kanokwan Changwichit, Piyarat Srisawang, Kornkanok Ingkaninan, Pornnarin Taepavarapruk
This study investigated the effect of Eulophia macrobulbon (EM) extract on sexual performance in aged-related erectile dysfunction (ED) rats. The ethanol EM extract at the doses of 15, 150, and 450 and sildenafil citrate at the dose of 5 mg/kg body weight (BW) were administered orally to the aged male rats once daily for 21 days. Mating parameters and intracavernosal pressure (ICP) were measured to evaluate their sexual and erection functions. Numbers of sperm and sperm motility as well as the diameter of seminiferous tubules were observed...
2018: BioMed Research International
Hai-Ping Zhao, Xue-Zhe Cui, Wei Zhang, Guang-Xin Chen, Wan-Yun Yang, Quan-Wei Wang, Chun-Yi Li
To investigate the effects of anti-androgen drugs and melengestrol acetate (MGA) on development of regrowth antlers in 6 year old sika deer, twenty healthysika deerwith similar body weight and antler weightwere randomly divided into five groups by using single factor test design: flutamide ( n =4), bicalutamide ( n =4), progesterone acetate (CPA, n =4), melengestrol acetate (MGA, n =4), control( n =4). All deer were fed with same diets and were housed outside together in an opened fence of 15 m×30 m with free access to water and feed...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Olugbemi Tope Olaniyan, Olufadekemi Tolulope Kunle-Alabi, Yinusa Raji
OBJECTIVES: Male infertility caused by exposure to heavy metals is a current global issue. Exposure to cadmium chloride (CdCl2 ) negatively affects the male reproductive system. Many infertile people, especially in developing countries, resort to folkloric treatment. Plukenetia conophora is used in Nigerian folk medicine to promote fertility. This study investigated the effects of Plukenetia conophora (PC) and 4H-Pyran-4-One 2,3-Dihydro-3,5-Dihydroxy-6-Methyl (DDMP) on Wistar rats with cadmium chloride-induced testicular damage...
August 14, 2018: JBRA Assisted Reproduction
Amr A Fouad, Marwa M M Refaie, Manal I Abdelghany
Cisplatin (CP) and doxorubicin (DX) can cause testicular injury by inducing oxidative/nitrosative stress, inflammation, and apoptosis, Naringenin (NG) has antioxidant, antinitrative, anti-inflammatory, and anti-apoptotic effects. This study investigated the potential ability of NG to block gonadotoxicity induced CP and DX in male rats. The rats received one injection of either CP (10 mg/kg, i.p.) or DX (15 mg/kg, i,p.), and treated with NG (50 mg/kg/day, p.o.) for 10 days beginning 6 days prior to CP and DX administration...
August 14, 2018: Toxicology Mechanisms and Methods
Jack W Barrow, Nefize Turan, Pasang Wangmo, Anil K Roy, Gustavo Pradilla
Background: Aneurysmal subarachnoid hemorrhage (aSAH) continues to be a devastating neurological condition with a high risk of associated morbidity and mortality. Inflammation has been shown to increase the risk of complications associated with aSAH such as vasospasm and brain injury in animal models and humans. The goal of this review is to discuss the inflammatory mechanisms of aneurysm formation, rupture and vasospasm and explore the role of sex hormones in the inflammatory response to aSAH...
2018: Surgical Neurology International
Michael V Lombardo, Bonnie Auyeung, Tiziano Pramparo, Angélique Quartier, Jérémie Courraud, Rosemary J Holt, Jack Waldman, Amber N V Ruigrok, Natasha Mooney, Richard A I Bethlehem, Meng-Chuan Lai, Prantik Kundu, Edward T Bullmore, Jean-Louis Mandel, Amélie Piton, Simon Baron-Cohen
Early-onset neurodevelopmental conditions (e.g., autism) affect males more frequently than females. Androgens may play a role in this male-bias by sex-differentially impacting early prenatal brain development, particularly neural circuits that later develop specialized roles in social cognition. Here, we find that increasing prenatal testosterone in humans is associated with later reduction of functional connectivity between social brain default mode (DMN) subsystems in adolescent males, but has no effect in females...
August 13, 2018: Molecular Psychiatry
Eleni Pitsouni, Themos Grigoriadis, Athanasios Douskos, Margarita Kyriakidou, Matthew E Falagas, Stavros Athanasiou
Genitourinary syndrome of menopause (GSM) increases the probability of female sexual dysfunction (FSD). The aim of the current study is to systematically assess data regarding sexual function and use of vaginal therapies, alternative to vaginal estrogens (VE), in menopausal women with GSM. PubMed, Scopus and Cochrane Library were searched (May-September 2017) using combination keywords: "dyspareunia and vaginal therapy", "sexual function and vaginal therapy", "orgasm and vaginal therapy", "vaginal atrophy" and "genitourinary syndrome of menopause"...
August 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Lidia Mínguez-Alarcón, Audrey J Gaskins, Yu-Han Chiu, Carmen Messerlian, Paige L Williams, Jennifer B Ford, Irene Souter, Russ Hauser, Jorge E Chavarro
STUDY QUESTION: Is self-reported type of underwear worn associated with markers of testicular function among men at a fertility center? SUMMARY ANSWER: Men who reported most frequently wearing boxers had higher sperm concentration and total count, and lower FSH levels, compared to men who did not. WHAT IS KNOWN ALREADY: Elevated scrotal temperatures are known to adversely affect testicular function. However, the epidemiologic literature on type of underwear, as a proxy of scrotal temperature, and male testicular function is inconsistent...
August 8, 2018: Human Reproduction
Jay S Mishra, Amar S More, Kathirvel Gopalakrishnan, Sathish Kumar
Sex hormone-dependent vascular reactivity is an underlying factor contributing to sex differences in blood pressure. Inappropriate activation of the renin-angiotensin system (RAS) is involved in vascular dysfunction and hypertension. This study evaluated the role of androgens (testosterone) in angiotensin II (Ang II) -induced increase in blood pressure, vascular reactivity and cardiac hypertrophy. Eight weeks-old male Wistar rats underwent sham operation, castration, or castration with testosterone replacement...
August 8, 2018: Biology of Reproduction
Sultan A Alqahtani, Naif M Alhawiti
This study investigated the effect of testosterone deficiency and replacement on platelets function and aggregation, coagulation, and fibrinolysis in young adult healthy male rats. Rats were classified into three groups (n = 6/group) of either "a sham-operated+ vehicle," "an orchidectomized (ORX)+ vehicle," and "an ORX+testosterone propionate (0.5 mg/kg, 3X/week, S.C)." All treatments were carried out for 12 weeks. Our results showed that ORX rats had induced platelets aggregation and coagulation and inhibited fibrinolysis...
August 13, 2018: Platelets
Giulia Rastrelli, Mauro Dicuio, Yacov Reismann, Alessandra Sforza, Mario Maggi, Giovanni Corona
Since 2010 some evidence supporting the possible increased cardiovascular (CV) risk related to testosterone treatment (TTh) has created much debate in the scientific community. Based on these results, the US Food and Drug Administration agency has questioned TTh for aging men recognizing its value only for classical hypogonadism due to genetic or organic causes. To better clarify this topic, we scrutinized and summarized, also by using meta-analytic methods, the data generated during the last seven years, as derived from the analysis of randomized controlled trials (RCTs) on TTh and CV risk...
August 13, 2018: Expert Review of Cardiovascular Therapy
Abdulmaged M Traish, Yonah Krakowsky, Gheorghe Doros, Abraham Morgentaler
INTRODUCTION: Many studies have reported that 5α-reductase inhibitors (finasteride and dutasteride) raise serum testosterone (T) levels, yet there is lack of consistency among studies on this point. AIM: To review and meta-analyze available studies reporting changes in serum T concentrations in men treated with 5α-reductase inhibitors (5α-RIs). METHODS: A Medline search using PubMed and EMBASE was performed including the following key words: "finasteride," "dutasteride," "testosterone and 5α-reductases...
August 8, 2018: Sexual Medicine Reviews
Silvia Castrignanò, Giovanna Di Nardo, Sheila J Sadeghi, Gianfranco Gilardi
The linker region of multi-domain enzymes has a very important role for the interconnection of different enzyme modules and for the efficiency of catalytic activity. This is particularly evident for artificial chimeric systems. We characterised an artificial self-sufficient enzyme developed by genetic fusion of the catalytic domain of cytochrome P450 3A4 and reductase domain of Bacillus megaterium BM3 (BMR). Here we report the direct electrochemistry of 3A4-BMR chimeras immobilised on glassy carbon electrodes and we investigated the effect of inter-domain loop length and immobilising environment flexibility on both redox properties and electrocatalysis...
August 4, 2018: Journal of Inorganic Biochemistry
Yi X Chan, Matthew W Knuiman, Mark L Divitini, David J Handelsman, John P Beilby, Bu B Yeap
Androgens, notably testosterone (T), have been implicated in development of several common cancers and prostate cancer; however, precise mechanisms remain unclear. This study assessed prospective associations of serum T, dihydrotestosterone (DHT) and estradiol (E2) with overall cancer (excluding skin cancer), prostate, colorectal and lung cancer risk in 1574 community-dwelling men aged 25-84 years. Sex hormones were assayed using mass spectrometry and men were followed for 20 years with outcomes ascertained using data linkage...
August 10, 2018: Hormones & Cancer
Heba Allah M Elbaghdady, Maha A Alwaili, Reda S El-Demerdash
The effect of bone marrow-derived mesenchymal stem cells on cadmium-induced liver and kidney damage was studied in Sprague Dawley rats. The study employed three animal groups: Group 1 served as control animals; Group 2 rats were dosed intra-peritoneally with 2 mg of cadmium chloride per kg body weight, and Group 3 rats were again dosed with a single intraperitoneal injection of 2 mg of cadmium chloride per kg body weight two doses of 106 cells each intravenously. Finally, the animals were killed using halothane inhalation anesthesia...
August 7, 2018: Ecotoxicology and Environmental Safety
Sonnet S Jonker, Samantha Louey, Charles E Roselli
Polycystic ovary syndrome (PCOS) is a complex and common disorder in women, and those affected experience an increased burden of cardiovascular disease. It is an intergenerational syndrome, as affected women with high androgen levels during pregnancy "program" fetal development, leading to a similar phenotype in their female offspring. The effect of excess maternal testosterone exposure on fetal cardiomyocyte growth and maturation is unknown. METHODS Pregnant ewes received biweekly injections of vehicle (Control) or 100 mg testosterone propionate between 30-59 days of gestation (dGA; Early T) or 60-90 dGA (Late T)...
August 10, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Daniel P Longman, Michele K Surbey, Jay T Stock, Jonathan C K Wells
Male-male competition is involved in inter- and intrasexual selection, with both endocrine and psychological factors presumably contributing to reproductive success in human males. We examined relationships among men's naturally occurring testosterone, their self-perceived mate value (SPMV), self-esteem, sociosexuality, and expected likelihood of approaching attractive women versus situations leading to child involvement. We then monitored changes in these measures in male rowers (N = 38) from Cambridge, UK, following a manipulated "win" or "loss" as a result of an indoor rowing contest...
August 9, 2018: Human Nature: An Interdisciplinary Biosocial Perspective
Jyoti Aggarwal, Rajesh Satyapal Taneja, Pulin Kumar Gupta, Mohsin Wali, Anubhuti Chitkara, Afroz Jamal
Background: In human immunodeficiency virus (HIV)-infected men, hypogonadism is the most common endocrinological disorder, and most cases of hypogonadism are secondary. The aim of this study was to find out the hormonal abnormalities in HIV-infected males and it's correlation with CD4 cell counts. Materials and Methods: One hundred HIV-infected male patients were evaluated in the Department of Medicine, Postgraduate Institute of Medical Education and Research and Dr...
May 2018: Indian Journal of Endocrinology and Metabolism
Ecem Özdemir, Nurhayat Barlas, Mehmet Alper Çetinkaya
Propyl paraben is a widely used preservative in pharmaceuticals, cosmetics, and foods preventing microbial and fungal contamination. This study was designed to investigate antiandrogenic profiles of propyl paraben following oral doses at 10, 250, and 750 mg kg-1 day to immature male rats using the Hershberger Bioassay. Rats were divided into six groups including solvent control, negative control (0.4 mg kg-1 day testosterone propionate = TP), positive control (3 mg kg-1 day flutamide = FLU) and treatment groups (10, 250, and 750 mg kg-1 day testosterone propionate + Propyl paraben)...
March 1, 2018: Toxicology Research
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