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Lymph Node Dissection

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https://www.readbyqxmd.com/read/30546885/pathological-complete-response-to-mfolfox6-plus-cetuximab-therapy-for-unresectable-colon-cancer-with-multiple-paraaortic-lymph-node-metastases
#1
Tomonari Suetsugu, Nobuhisa Matsuhashi, Takao Takahashi, Toshiyuki Tanahashi, Satoshi Matsui, Hisashi Imai, Yoshihiro Tanaka, Kazuya Yamaguchi, Kazuhiro Yoshida
Pathological complete response is achievable with mFOLFOX6 plus cetuximab therapy for unresectable colorectal cancer with multiple paraaortic lymph node metastases (mCRC) despite right-sided colonic origin. A 62-year-old woman with synchronous paraaortic lymph node metastases of transverse colon cancer was treated with mFOLFOX6 plus cetuximab as first-line therapy. The tumor size was markedly decreased following 6 courses of chemotherapy, and all lymph node metastases had disappeared. The patient then underwent conventional right hemicolectomy with D3 lymph node dissection plus sampling excision of the paraaortic lymph nodes...
December 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30546416/rare-case-of-idiopathic-sclerosing-cholangitis-which-was-difficult-to-distinguish-from-cholangiocarcinoma-a-case-report
#2
Shunsuke Shichi, Takahiro Einama, Mayu Suzuki, Hiroki Matsui, Ryo Kanazawa, Kazuaki Shibuya, Takashi Suzuki, Fumihiko Matsuzawa, Kohei Nakachi, Taku Hashimoto, Nobuo Kondo, Hironori Abe, Akinobu Taketomi
It is often difficult to correctly diagnose patients who present with dilation of the bile duct. Cholangiocarcinoma, primary sclerosing cholangitis (PSC) and immunoglobulin (Ig)G4-related sclerosing cholangitis must be considered as potential diagnoses for these cases. The current study presents a 73-year-old female patient who presented with a high fever and abdominal pain. Contrast-enhanced computed tomography and magnetic resonance cholangiopancreatography revealed stenosis and dilation of the intrahepatic bile duct without solid components...
December 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30545809/benefits-of-elective-para-aortic-radiotherapy-for-pn1-prostate-cancer-using-arc-therapy-intensity-modulated-or-volumetric-modulated-arc-therapy-protocol-for-a-nonrandomized-phase-ii-trial
#3
Cédric Draulans, Steven Joniau, Valérie Fonteyne, Louke Delrue, Karel Decaestecker, Wouter Everaerts, Piet Dirix, Laura Van den Bergh, Wouter Crijns, Hans Vandendriessche, Lodewijk Van Wynsberge, Piet Ost, Nicolaas Lumen, Pieterjan Buelens, Karin Haustermans, Charlien Berghen, Gert De Meerleer
BACKGROUND: In patients with prostate cancer (PCa) with histopathologically proven pelvic lymph node (LN) metastasis (pN1) after extended pelvic lymph node dissection (ePLND), multimodality treatment consisting of treatment of the primary tumor and whole pelvic radiotherapy (WPRT) combined with androgen deprivation therapy (ADT) offers promising results, leading to better cause-specific survival rates compared with ADT alone. However, in case more than one pelvic LN is invaded by the tumor, approximately 40% of the patients relapse biochemically and clinically...
December 13, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/30544433/prognostic-significance-of-the-degree-of-lymphatic-vessel-invasion-in-locally-advanced-surgically-resectable-pancreatic-head-cancer-a-single-center-experience
#4
Kohei Morita, Hisashi Oshiro, Kumiko Mito, Makiko Naka Mieno, Mio Tamba-Sakaguchi, Toshiro Niki, Atsushi Miki, Masaru Koizumi, Yasunaru Sakuma, Toshihide Komatsubara, Naohiro Sata, Noriyoshi Fukushima
Little is known concerning the prognostic significance of the degree of lymphatic vessel invasion in pancreatic head cancer. To address this gap in knowledge, we retrospectively examined 60 patients with locally advanced, surgically resectable pancreatic head cancer who underwent pancreaticoduodenectomy and lymph node (LN) dissection.All cases were histopathologically diagnosed as ductal adenocarcinoma, stage II (25 pT3N0 cases, 35 pT3N1 cases). The following variables were investigated: age; sex; neoadjuvant therapy; adjuvant therapy; tumor size; tumor grade; invasion into the serosa, retropancreatic tissue, duodenum, bile duct, portal venous system and perineural area; cut margins; LN metastasis; and the number of invaded lymphatic vessels (LVI-score)...
December 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30544366/primary-small-cell-carcinoma-after-renal-transplant-a-case-report
#5
Xueli Wang, Fenghua Wang, Yumei Liang, Wen Chen
INTRODUCTION: Primary small cell carcinoma (SCC) after renal transplantation is very rare. Here, we reported 1 case of primary SCC after renal transplantation and analyzed its clinical and pathological characteristics. CASE PRESENTATION: A 55-year-old female underwent renal transplantation in our hospital 2 years ago and had been using tacrolimus for immunosuppressive therapy. Because of abdominal distention, the patient was admitted to our hospital. Computed tomography (CT) showed a malignant tumor of left kidney...
December 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30544106/biology-based-surgery-the-extent-of-lymphadenectomy-in-cancer-of-the-colon
#6
Wouter Willaert, Sarah Cosyns, Wim Ceelen
The progression of colon cancer (CC) involves hematogenous and lymphatic spread to locoregional lymph nodes (LN), distant LN, and metastatic sites including the liver. The biological mechanisms that govern CC progression remain elusive. The Halsted model assumes an orderly, stepwise progression from the primary tumor to nearby nodes, henceforth to anatomically more distant nodes, and ultimately to distant organs. The Fisher model, on the other hand, regards the release of metastatic cells as early and essentially random events...
December 13, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30539751/the-expression-profile-of-p14-p53-and-p21-in-tumour-cells-is-associated-with-disease-specific-survival-and-the-outcome-of-postoperative-chemotherapy-treatment-in-muscle-invasive-bladder-cancer
#7
Firas Aljabery, Ivan Shabo, Oliver Gimm, Staffan Jahnson, Hans Olsson
PURPOSE: We investigated the effects of alterations in the biological markers p14, p53, p21, and p16 in relation to tumour cell proliferation, T-category, N- category, lymphovascular invasion, and the ability to predict prognosis in patients with muscle-invasive bladder cancer (MIBC) treated with cystectomy and, if applicable, chemotherapy. MATERIALS AND METHODS: We prospectively studied patients with urinary bladder cancer pathological stage pT1 to pT4 treated with cystectomy, pelvic lymph node dissection and postoperative chemotherapy...
December 2018: Urologic Oncology
https://www.readbyqxmd.com/read/30539261/transoral-robotic-thyroidectomy-for-papillary-thyroid-carcinoma-perioperative-outcomes-of-100-consecutive-patients
#8
Hong Kyu Kim, Young Jun Chai, Gianlorenzo Dionigi, Eren Berber, Ralph P Tufano, Hoon Yub Kim
BACKGROUND: Endoscopic transoral thyroidectomy is a recently introduced technique of remote access thyroidectomy. We previously reported the feasibility of the robotic approach (TORT). Nevertheless, experience to date is limited, with scant data on outcomes in patients with papillary thyroid carcinoma (PTC). METHODS: This was a retrospective analysis of prospectively collected data. Patients with PTC, who underwent TORT at a single center between March 2016 and February 2017, were analyzed...
December 11, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/30538406/multiple-gastrointestinal-cancers-in-a-single-patient-a-rare-clinical-entity
#9
Manish Sahni, Ashish Goel, Pankaj Pande, Kapil Kumar
Multiple gastrointestinal cancers in a single patient is a rare entity. In our study, we are showing the clinical presentation and management of these patients. A fifty-nine-year-old asthenic male (already treated case of metachronous colorectal cancer in 2008 and 2011) presented with complaints of generalized weakness and fatigue. Strong family history was present with two of his first-degree relatives having diagnosed with gastrointestinal cancer at the age < 50 years with one of them having stomach carcinoma and another with GEJ tumors...
December 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30536753/extent-of-lateral-neck-dissection-for-papillary-thyroid-microcarcinomas
#10
Joon-Hyop Lee, Yong Soon Chun, Yoo Seung Chung
BACKGROUND: Papillary thyroid microcarcinomas (PTMCs) often demonstrate lateral lymph node (LN) metastasis. The purpose of this study was to assess whether the size of primary tumor should be considered in deciding lateral neck dissection extent. METHODS: We conducted a retrospective comparison of patients with PTMC and papillary thyroid carcinoma (PTC) larger than 1 cm who received lateral LN dissection from 2009 to 2015. RESULTS: PTMC group had more frequent metachronous metastasis, multifocality, less involvement of lower third thyroid, lower metastatic central LN counts and ratio, and lower metastatic total LN ratio...
December 10, 2018: Head & Neck
https://www.readbyqxmd.com/read/30536535/superior-detection-of-metastatic-cystic-lymphadenopathy-in-patients-with-papillary-thyroid-cancer-by-utilization-of-thyroglobulin-washout
#11
Helmi Khadra, Hossam Mohamed, Zaid Al-Qurayshi, Andrew Sholl, Mary Killackey, Emad Kandil
BACKGROUND: Fine-needle aspiration (FNA) cytology has been the standard of care in the workup of cervical lymph nodes (LNs) in patients with recurrent papillary thyroid cancer (PTC) and suspicious cervical LNs. Recently, FNA thyroglobulin (TG) washout measurement has been proposed as an adjunct in the management of these patients. We hypothesize that using FNA-TG washout for suspicious cervical LNs would increase the accuracy of diagnosing metastatic disease especially in cystic and highly vascular cervical LN in patients with recurrent PTC...
December 9, 2018: Head & Neck
https://www.readbyqxmd.com/read/30531112/-a-case-of-jejunal-neuroendocrine-carcinoma-complicated-with-dermatomyositis
#12
Natsumi Azuma, Tatsunori Satoh, Shinya Kawaguchi, Takeshi Oshima, Hiroyuki Muro, Keisei Taku
A 65-year-old woman who had been diagnosed with dermatomyositis presented to the hospital with a small bowel mass. She had tested positive for fecal occult blood test and anemia at a medical checkup;therefore, computerized tomography (CT) was performed at the previous hospital and it had revealed thickening of the intestinal wall. Abdominal contrast-enhanced CT, single-balloon assisted enteroscopy, and biopsy led to a diagnosis of poorly differentiated jejunal adenocarcinoma. The patient underwent laparoscopic segmental resection of the jejunum with dissection of mesenteric lymph nodes...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/30528947/the-limited-role-of-elective-neck-dissection-in-patients-with-cn0-salivary-gland-carcinoma
#13
Kai Qian, Kai Guo, Xiaoke Zheng, Wenyu Sun, Tuanqi Sun, Lili Chen, Ding Ma, Yi Wu, Qinghai Ji, Zhuoying Wang
PURPOSE: To evaluate whether elective neck dissection (END) was beneficial for cN0 patients with salivary gland carcinoma. MATERIALS AND METHODS: The rates of regional failure-free survival and disease-free survival were calculated using Kaplan-Meier methods and Cox models. The risk factors for occult lymph node metastasis (OLNM) in cN0 patients undergoing END was analyzed using logistic regression. A nomogram was formulated to calculate the estimated probability of OLNM...
November 22, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/30527745/more-extensive-lymph-node-dissection-improves-survival-benefit-of-radical-cystectomy-in-metastatic-urothelial-carcinoma-of-the-bladder
#14
Elio Mazzone, Felix Preisser, Sebastiano Nazzani, Zhe Tian, Nicola Fossati, Giorgio Gandaglia, Andrea Gallina, Denis Soulieres, Derya Tilki, Francesco Montorsi, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Pierre I Karakiewicz
BACKGROUND: Radical cystectomy (RC) may occasionally be performed in individuals with metastatic urothelial carcinoma of the bladder (mUCB). However, the role of lymph node dissection (LND) for such cases is unknown. Thus, we tested the effect of RC on cancer-specific mortality (CSM) and overall mortality in mUCB patients and the effect of LND and its extent on CSM. PATIENTS AND METHODS: Within the Surveillance, Epidemiology, and End Results (SEER) database (2004-2013), we identified patients with mUCB who underwent RC with or without LND or non-RC management...
November 17, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/30527676/comparison-of-retroauricular-and-small-transcervical-approaches-for-endoscopic-assisted-selective-neck-dissection-a-cadaveric-study
#15
S Lee, W Nam
Advances in endoscopic-assisted neck surgery have allowed surgeons to conceal the scars via various approaches. However, studies comparing the approaches are still rare. The aim of this study was to comparatively analyze the feasibility and oncological outcomes of the retroauricular approach (RA) and the small transcervical approach (STC) for endoscopic-assisted selective neck dissection (EASND). Five fresh cadavers were recruited. EASND was performed via RA on one side and via STC on the contralateral side of each of the cadavers...
December 4, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30527517/management-of-asymptomatic-well-differentiated-pnets-results-of-the-delphi-consensus-process-of-the-americas-hepato-pancreato-biliary-association
#16
John C Mansour, Kenneth Chavin, Gareth Morris-Stiff, Susanne G Warner, Kenneth Cardona, Zhi V Fong, Ajay Maker, Steven K Libutti, Robert Warren, Charles St Hill, Scott Celinski, Philippa Newell, Quan P Ly, James Howe, Natalie Coburn
BACKGROUND: Variation in the management of PNETs exist due to the limited high-level evidence to guide clinical practice. The aim of this work is to generate consensus guidelines with a Delphi process for managing PNETs. METHODS: A panel of experts reviewed the surgical literature and scored a set of clinical case statements using a web-based survey to identify areas of agreement and disagreement. Results of the survey were discussed after each round of review. This cycle was repeated until no further likelihood of reaching consensus existed...
December 5, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30527237/nodal-volume-as-a-prognostic-factor-in-locally-advanced-head-and-neck-cancer-identifying-candidates-for-elective-neck-dissection-after-chemoradiation-with-igrt-from-a-single-institutional-prospective-series-from-the-indian-subcontinent
#17
Bharat Dua, Kundan S Chufal, Anshul Bhatnagar, Anil Thakwani
OBJECTIVE: Nodal volume as a prognostic factor has been extensively evaluated in head and neck cancer, however there is still no consensus. We attempted to analyze nodal volume as a prognostic factor in head and neck cancer treated with chemoradiation (CCRT) without an elective neck dissection with image guided intensity modulated radiotherapy (IG-IMRT). MATERIAL AND METHODS: We prospectively analysed 87 patients of Stage III-IV cancer of the oropharynx (57), and hypopharynx (30), who subsequently received definitive concurrent chemoradiation...
December 2018: Oral Oncology
https://www.readbyqxmd.com/read/30527226/optimal-extent-of-lateral-neck-dissection-for-well-differentiated-thyroid-carcinoma-with-metastatic-lateral-neck-lymph-nodes-a-systematic-review-and-meta-analysis
#18
REVIEW
Ho-Ryun Won, Jae Won Chang, Yea Eun Kang, Jae Yoon Kang, Bon Seok Koo
The purpose of this systematic review and meta-analysis was to determine the optimal extent of lateral neck dissection in patients with well-differentiated thyroid carcinoma with clinically confirmed lateral neck lymph node metastases. All studies reporting the distribution of metastatic lymph nodes in level IIb or level V, complication rate, recurrence rate, or clinical outcomes according to the extent of lateral neck dissection were collected from MEDLINE and Embase databases. Two reviewers independently retrieved articles, extracted data, and assessed the quality of the studies...
December 2018: Oral Oncology
https://www.readbyqxmd.com/read/30526642/a-prospective-study-on-dual-time-18-f-fdg-pet-ct-in-high-risk-prostate-cancer-patients
#19
Mike Allan Mortensen, Mie Holm Vilstrup, Mads Hvid Poulsen, Oke Gerke, Poul Flemming Høilund-Carlsen, Lars Lund
OBJECTIVE: This proof of concept study investigated whether dual time point FDG-PET/CT with image acquisition after 1 and 3 h could be useful in preoperative staging of patients undergoing robot-assisted radical prostatectomy and extended pelvic lymph node dissection for high-risk prostate cancer. RESULTS: Twenty patients with high-risk prostate cancer underwent dual time point FDG-PET/CT before undergoing surgery. Histologically confirmed lymph node metastases were found in 9/20 (45%)...
December 7, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/30526184/outcome-of-sentinel-lymph-node-biopsy-in-patients-with-clinically-non-metastatic-renal-cell-carcinoma
#20
Teele Kuusk, Roderick De Bruijn, Oscar R Brouwer, Jeroen De Jong, Maarten Donswijk, Kees Hendricksen, Simon Horenblas, Katarzyna Jóźwiak, Warner Prevoo, Renato A Valdés Olmos, Henk G Van Der Poel, Bas Wg Van Rhijn, Esther M Wit, Axel Bex
OBJECTIVE: To investigate the rate of occult SN metastases, oncological outcome, and association of recurrence with the pattern of lymphatic tumour drainage in RCC. MATERIALS AND METHODS: A pooled RCC sub-group analysis was conducted of secondary endpoints from a published feasibility and a phase II prospective single-arm SN study to investigate oncological outcome. Patients with cT1-3 (<10 cm) cN0M0 RCC of any sub-type were enrolled. After intratumoural injection of Tc99m nanocolloid, pre-operative imaging of SNs with SPECT/CT was followed by (partial) nephrectomy with SN and regional lymph node dissection using a γ-probe...
December 11, 2018: Scandinavian Journal of Urology
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