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Lobe-specific Node Dissection

Run-Bin Liang, Jie Yang, Tai-Shan Zeng, Hao Long, Jian-Hua Fu, Lan-Jun Zhang, Peng Lin, Xin Wang, Tie-Hua Rong, Xue Hou, Hao-Xian Yang
OBJECTIVE: We aimed to investigate the incidence and distribution of mediastinal lymph node metastases (MLNM) in operable non-small cell lung cancer (NSCLC) with the purpose of guiding mediastinal lymph node dissection (MLND). METHODS: A total of 4511 NSCLC patients who underwent resection between January 2001 and December 2014 were included. These patients were preoperatively untreated and grouped according to the primary tumor lobes. The incidence and distribution of pathologic MLNM were compared among groups, and multivariate analysis was conducted to find the independent factors impacting MLNM...
August 6, 2018: Annals of Surgical Oncology
Han-Yu Deng, Chang-Long Qin, Gang Li, Guha Alai, Yidan Lin, Xiao-Ming Qiu, Qinghua Zhou
Background: Whether lobe-specific lymph node dissection (L-SLND) could serve as an alternative to systematic lymph node dissection (SLND) in treating early-stage non-small cell lung cancer (NSCLC) remains unclear. Therefore, we conducted this comprehensive meta-analysis to compare the effect of L-SLND with that of SLND in treating early-stage NSCLC. Methods: A systematic literature search in PubMed and Embase was conducted to identify relevant studies up to 30 November 2017...
May 2018: Journal of Thoracic Disease
T Zhang, Y Qu, L He, L Shao, D L Zhang, C Z Lü, P Zhang, H Zhang
Objective: To investigate the risk factors and preoperative evaluation of lymph nodes posterior to right recurrent laryngeal nerve (LN-prRLN) metastasis in papillary thyroid carcinoma (PTC). Methods: Clinical data of 301 patients with right or double lobes who underwent surgery between August 2015 and October 2016 in the Department of Thyroid Surgery, the First Hospital of China Medical University, were retrospectively analyzed. The relationships between LN-prRLN metastasis and clinical pathology data and other factors were analyzed...
June 12, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Catarina Carvalheiro, Javier Gallego-Poveda, Diego Gonzalez-Rivas, Jorge Cruz
INTRODUCTION: Interest in uniportal video-assisted thoracic surgery (VATS) is rapidly growing worldwide because it represents the surgical approach to the lung with the least possible trauma and in recent years the subxiphoid approach has been used in the field of thoracic surgery as it is associated with lesser pain because there is no intercostal nerve damage and it provides excellent cosmetic outcomes. This technique was recently introduced for major pulmonary resections and even bilateral approaches in selected patients...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
Katrine Jensen, René Horsleben Petersen, Henrik Jessen Hansen, William Walker, Jesper Holst Pedersen, Lars Konge
BACKGROUND: Specific assessment tools can accelerate trainees' learning through structured feedback and ensure that trainees attain the knowledge and skills required to practice as competent, independent surgeons (competency-based surgical education). The objective was to develop an assessment tool for video-assisted thoracoscopic surgery (VATS) lobectomy by achieving consensus within an international group of VATS experts. METHOD: The Delphi method was used as a structured process for collecting and distilling knowledge from a group of internationally recognized VATS experts...
March 30, 2018: Surgical Endoscopy
Xiangyang Yu, Yingsheng Wen, Rongqing Qin, Yongbin Lin, Xuewen Zhang, Weidong Wang, Yongqiang Chen, Lanjun Zhang
BACKGROUND: Primary pulmonary lymphoepithelioma-like carcinoma is a rare subtype of lung cancer. Until now, the characteristics of lymph nodes metastases in resectable cases have not yet been reported. METHODS: In this study, a total of 87 consecutive patients with primary pulmonary lymphoepithelioma-like carcinoma that received surgical treatment were investigated from October 1999 to August 2016. The clinical and radiological data and follow-up information were extracted from hospital records in detail...
March 2018: Thoracic Cancer
Hiroyuki Adachi, Takamitsu Maehara, Haruhiko Nakayama, Munetaka Masuda
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
Tomoyuki Hishida, Hisashi Saji, Shun-Ichi Watanabe, Hisao Asamura, Keiju Aokage, Tomonori Mizutani, Masashi Wakabayashi, Taro Shibata, Morihito Okada
In January 2017, the Lung Cancer Surgical Study Group of the Japan Clinical Oncology Group commenced a randomized Phase III trial to confirm the clinical benefit of lobe-specific nodal dissection for clinical Stage I-II non-small cell lung cancer. The primary endpoint is overall survival, and the main objective is to confirm the non-inferiority of lobe-specific in comparison to systematic nodal dissection with regard to lobectomy. The secondary endpoints are relapse-free survival, %local recurrence, %regional lymph node recurrence, operation time, blood loss, length of hospitalization, duration of chest tube placement and adverse events...
February 1, 2018: Japanese Journal of Clinical Oncology
Han Han, Haiquan Chen
Lymph node dissection is a vital part of surgical treatment in early-stage non-small cell lung cancer (NSCLC). Removal of metastatic lymph nodes while preservation of intact lymph nodes are equally important. For hospitalized early-stage patients with limited lymph node metastasis, the operation treatment should be made according to some rules such as lobe-specific lymph node drainage pattern. In order to prevent unnecessary surgical trauma in early-stage patients, a minimally invasive approach with selective lymph node excision is preferred for more clinical benefits...
July 2017: Journal of Thoracic Disease
Karolien E Goffin, Steven Joniau, Peter Tenke, Kevin Slawin, Eric A Klein, Nancy Stambler, Thomas Strack, John Babich, Thomas Armor, Vivien Wong
(99m)Tc-trofolastat ((99m)Tc-MIP-1404), a small-molecule inhibitor of prostate-specific membrane antigen, shows high potential to detect prostate cancer (PCa) noninvasively using SPECT. We therefore wanted to assess the performance of (99m)Tc-trofolastat SPECT/CT in a phase 2 multicenter, multireader prospective study in patients with intermediate- and high-grade PCa, before radical prostatectomy and extended pelvic lymph node (LN) dissection, with histopathology as the gold standard. Methods: PCa patients (n = 105) with an increased risk of LN involvement (LNI) underwent pelvic (99m)Tc-trofolastat SPECT/CT before radical prostatectomy with extended pelvic LN dissection...
September 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Andrea Bille, Kaitlin M Woo, Usman Ahmad, Nabil P Rizk, David R Jones
Objectives: Early clinical stage (T1 and T2) non-small cell lung cancer (NSCLC) is commonly treated with anatomic lung resection and lymph node sampling or dissection. The aims of this study were to evaluate the incidence and the distribution of occult N2 disease according to tumour location and the short- and long-term outcomes. Methods: We performed a retrospective review of patients with clinical stage I NSCLC who underwent anatomic lung resection and lymphadenectomy...
April 1, 2017: European Journal of Cardio-thoracic Surgery
Stylianos Korasidis, Cecilia Menna, Claudio Andreetti, Giulio Maurizi, Antonio D'Andrilli, Anna Maria Ciccone, Francesco Cassiano, Erino Angelo Rendina, Mohsen Ibrahim
An accurate staging of a malignant disease is imperative in order to plan pre- and post-operative therapy, define prognosis and compare studies. According to the European Society of Thoracic Surgeons (ESTS) guidelines a systematic lymph node (LN) dissection is recommended in all cases of pulmonary resection for non-small cell lung cancer (NSCLC). The current lung cancer staging system considers the lymphatic stations involved but not the number of LNs. Up to date, published scientific studies on hilar and mediastinal lymphadenectomy mainly have been regarded the type of LN dissection procedure after pulmonary resection (selected LN biopsy, LN sampling, systematic nodal dissection, lobe specific nodal dissection and extended LN dissection) focusing particularly on the comparison between mediastinal LN dissection (MLND) and mediastinal LN sampling (MLNS)...
October 2016: Annals of Translational Medicine
Frank C Detterbeck
No abstract text is available yet for this article.
September 2016: Journal of Thoracic Oncology
Hiroyuki Adachi, Kentaro Sakamaki, Teppei Nishii, Taketsugu Yamamoto, Takuya Nagashima, Yoshihiro Ishikawa, Kohei Ando, Kazuki Yamanaka, Katsuya Watanabe, Yutaka Kumakiri, Masahiro Tsuboi, Takamitsu Maehara, Haruhiko Nakayama, Munetaka Masuda
INTRODUCTION: Systematic lymph node dissection (SND) is the standard procedure in surgical treatment for NSCLC, but the value of this approach for survival and nodal staging is still uncertain. In this study, we evaluated the potential of lobe-specific lymph node dissection (L-SND) in surgery for NSCLC by using a propensity score matching method. METHODS: From 2005 to 2007, 565 patients with cT1a-2b N0-1 M0 NSCLC underwent lobectomy with lymph node dissection at our 10 affiliated hospitals...
January 2017: Journal of Thoracic Oncology
Ningning Ding, Yousheng Mao
Lung cancer ranks the first position in morbidity and mortality among all malignances in China. Non-small cell lung cancer (NSCLC) accounts for nearly 80% of all lung malignancies. Surgical resection is still the current major treatment method for early stage NSCLC. Lymph node stages together with the extent of lymph node dissection directly affect the prognosis. Anatomical lobectomy with systematic mediastinal lymph node dissection have been the standard surgical treatment for NSCLC. However, it is controversial in the extent of lymph node dissection for early stage NSCLC...
June 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Tomoyuki Hishida, Etsuo Miyaoka, Kohei Yokoi, Masahiro Tsuboi, Hisao Asamura, Katsuyuki Kiura, Kazuhisa Takahashi, Hirotoshi Dosaka-Akita, Hideo Kobayashi, Hiroshi Date, Hirohito Tada, Meinoshin Okumura, Ichiro Yoshino
OBJECTIVES: The purpose of this study was to assess the surgical outcomes according to the extent of mediastinal lymph node dissection for patients with NSCLC by using a nationwide registry database. METHODS: From among 11,663 patients in a Japanese lung cancer registry study for 2004, 5392 patients with clinical stage (c-stage) I or II NSCLC that was completely resected by lobectomy and either systematic (SND) or lobe-specific nodal dissection (LSD) were enrolled...
September 2016: Journal of Thoracic Oncology
Aikaterini Marini, Meletios Kanakis, Konstantinos Valakis, Nikolaos Laschos, Maria Chorti, Achilleas Lioulias
Thyroid carcinoma showing thymic-like differentiation (CASTLE) comprises a rare neoplasm of the thyroid gland which arises from ectopic thymic tissue or remnants of brachial pouches. CASTLE is regarded as an indolent neoplasm with a favorable prognosis, irrespective of its metastatic potential. Diagnosis is difficult as clinicopathological features have not been yet well-defined. Radiological findings are not specific and only immunohistochemical positivity for CD5 and CD117 staining is highly suggestive of CASTLE...
2016: Case Reports in Medicine
Paul Lalire, Mohamed Zalzali, Christian Garbar, Claire Bruna-Muraille, David Morland
A 70-year-old man with prostate cancer and increased prostate-specific antigen level of 55 ng/mL underwent staging F-fluorocholine PET/CT, which demonstrated the primary prostate tumor and a focal area corresponding to a 2-cm hypodense nodule in the left thyroid lobe. Fine-needle aspiration and subsequent total thyroidectomy with central lymph node dissection showed an oxyphilic papillary thyroid carcinoma and a medullary microcarcinoma. Oxyphilic tumors represent a significant proportion of the few case reports of incidental focal thyroid fluorocholine thyroid uptake...
June 2016: Clinical Nuclear Medicine
Daniel P Nguyen, Philipp M Huber, Tobias A Metzger, Vera Genitsch, Hans H Schudel, George N Thalmann
Sentinel lymph node (SLN) detection techniques have the potential to change the standard of surgical care for patients with prostate cancer. We performed a lymphatic mapping study and determined the value of fluorescence SLN detection with indocyanine green (ICG) for the detection of lymph node metastases in intermediate- and high-risk patients undergoing radical prostatectomy and extended pelvic lymph node dissection. A total of 42 patients received systematic or specific ICG injections into the prostate base, the midportion, the apex, the left lobe, or the right lobe...
November 2016: European Urology
Yingying Xiang, Kuailu Lin, Siyang Dong, L I Qiao, Qiuxiang He, Xiaohua Zhang
Central lymph node metastasis (CLNM) is common in papillary thyroid microcarcinoma (PTMC). The aim of the present study was to investigate the risk factors associated with CLNM in clinical lateral cervical lymph node-negative (cN0) PTMC in Eastern China. A total of 392 patients with confirmed PTMC by histological examination who underwent thyroidectomy and central neck lymph node dissection (CND) between May 2011 and October 2012 at the First Affiliated Hospital of Wenzhou Medical University (Wenzhou, China) were enrolled...
October 2015: Oncology Letters
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