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https://www.readbyqxmd.com/read/30518009/-effect-of-mir-21-on-the-expression-of-interleukin-10-in-b-cell-of-patients-with-henoch-schonlein-purpura
#1
Y Luo, Y Y Huang, Y Jin, C R Li, J Yang
Objective: To investigate the effect of microRNAs (miR)-21 on the expression of interleukin (IL)-10 in B cell of patients with Henoch-Schonlein purpura (HSP). Methods: From March 2016 to January 2017, twenty-four children with HSP hospitalized in rheumatology and immunology department of Shenzhen Children's Hospital were enrolled into the study, including 12 males and 12 females. Patients were divided into purpura nephritis group (HSPN, 14 cases) and non-nephritis group (NHSPN, 10 cases). The age-matched 34 healthy children were included as the control group for prospective cohort study...
December 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/30517121/subclinical-parameters-of-arterial-stiffness-and-arteriosclerosis-correlate-with-qrisk3-in-systemic-lupus-erythematosus
#2
Mónica Vázquez-Del Mercado, Felipe de J Perez-Vazquez, Eduardo Gomez-Bañuelos, Efrain Chavarria-Avila, Arcelia Llamas-García, Karla I Arrona-Rios, Gustavo Ignacio Diaz-Rubio, Sergio Durán-Barragán, Rosa E Navarro-Hernández, Bethel P Jordán-Estrada, Natalia Prado-Bachega, Miguel A A Gonzalez-Beltran, Carlos Ramos-Becerra, Fernando Grover-Paez, David Cardona-Müller, Ernesto G Cardona-Muñoz
It is well known that cardiovascular diseases (CVD) are a major contributor of death in systemic lupus erythematosus (SLE) as well in other rheumatic illness. In the last decades, there has been a growing development of different methodologies with the purpose of early detection of CVD. OBJECTIVE: The aim of this study is to correlate the usefulness of subclinical parameters of vascular aging and QRISK 3-2017 score for early detection of CVD in SLE. METHODS: Clinical assessment including systemic lupus erythematosus disease activity index (SLEDAI) and systemic lupus international collaborating clinics / american college of rheumatology damage index (SLICC/ACR DI), laboratory measurements, carotid ultrasound examination, carotid intima media thickness (cIMT) measurement, carotid distention and diameter analysis, arterial stiffness measurement measured by tonometry and QRISK 3-2017 were done...
2018: PloS One
https://www.readbyqxmd.com/read/30516323/nurse-telephone-education-for-promoting-a-treat-to-target-approach-in-recently-diagnosed-rheumatoid-arthritis-patients-a-pilot-project
#3
Siobhan Farley, Bonita Libman, Melinda Edwards, Carl J Possidente, Amanda G Kennedy
OBJECTIVE: The aim of the present study was to implement a nurse telephone education programme for patients with recently diagnosed rheumatoid arthritis (RA) that promotes shared decision-making and a treat-to-target approach. METHODS: This was a pilot project of newly diagnosed adult RA patients conducted between November 2015 and December 2016. A rheumatology clinic nurse telephoned patients to offer disease education. A toolkit was mailed to patients. Measures included call attempts, call time, a qualitative description of free-text notes and the proportion of patients who adhered to their next clinic visit...
December 5, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/30514320/protective-parents-and-permissive-children-what-qualitative-interviews-with-parents-and-children-can-tell-us-about-the-feasibility-of-juvenile-idiopathic-arthritis-trials
#4
Frances C Sherratt, Louise Roper, Simon R Stones, Flora McErlane, Matthew Peak, Michael W Beresford, Helen Foster, Athimalaipet V Ramanan, Madeleine Rooney, Eileen Baildam, Bridget Young
BACKGROUND: Patient recruitment can be very challenging in paediatric studies, especially in relatively uncommon conditions, such as juvenile idiopathic arthritis (JIA). However, involving children and young people (CYP) in the design of such trials could promise a more rapid trajectory towards making evidence-based treatments available. Studies involving CYP are advocated in the literature but we are not aware of any early stage feasibility studies that have qualitatively accessed the perspectives of parents and CYP with a long term condition to inform design and conduct of a trial...
December 4, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/30513782/sarcopenia-in-patients-with-rheumatic-diseases-prevalence-and-associated-risk-factors
#5
Michele Barone, Maria Teresa Viggiani, Maria Grazia Anelli, Rosalinda Fanizzi, Orsola Lorusso, Giuseppe Lopalco, Luca Cantarini, Alfredo Di Leo, Giovanni Lapadula, Florenzo Iannone
The prevalence of sarcopenia in rheumatic diseases has been evaluated in single diseases using various diagnostic approaches, generating conflicting data on the pathogenetic mechanism(s). Herein, we evaluated both muscle mass index (MMI) and muscle strength to assess sarcopenia and presarcopenia in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Moreover, we evaluated the possible impact of disease/patient-related characteristics, therapeutic regimens, and nutritional aspects on sarcopenia...
December 1, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30511295/microrna-132-mir-146a-and-mir-155-as-potential-biomarkers-of-methotrexate-response-in-patients-with-rheumatoid-arthritis
#6
Ankita Singh, Pradeepta Sekhar Patro, Amita Aggarwal
INTRODUCTION: Rheumatoid arthritis (RA) patients have high expression levels of hsa-miR-132-3p, hsa-miR-146a-5p, and hsa-miR-155-5p in peripheral blood. We studied if baseline blood levels of these microRNAs (miRNAs) could predict response to methotrexate (MTX). METHODS: RA patients (the American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria) with active disease (disease-modifying anti-rheumatic drug (DMARD)-naïve and Disease Activity Score 28 (DAS28) > 3...
December 3, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30509155/complete-urological-evaluation-including-sperm-dna-fragmentation-in-male-systemic-lupus-erythematosus-patients
#7
B C Tiseo, E Bonfá, E F Borba, G A Munhoz, Gja Wood, M Srougi, C A Silva, M Cocuzza
OBJECTIVE: To evaluate sperm DNA fragmentation analysis in non-azoospermic male systemic lupus erythematosus (SLE) patients. METHODS: Twenty-eight consecutive male SLE patients (American College of Rheumatology criteria) and 34 healthy controls were evaluated for demographic/exposures data, urological evaluation, hormone profile and sperm analysis (including sperm DNA fragmentation). Clinical features, disease activity/damage scores and treatment were also evaluated...
December 3, 2018: Lupus
https://www.readbyqxmd.com/read/30508444/how-would-you-manage-this-patient-with-gout-grand-rounds-discussion-from-beth-israel-deaconess-medical-center
#8
Risa B Burns, C Christopher Smith, Robert H Shmerling, Anjala Tess
Gout is the most common form of inflammatory arthritis. In 2012, the American College of Rheumatology (ACR) issued a guideline, which was followed in 2017 by one from the American College of Physicians (ACP). The guidelines agree on treating acute gout with a corticosteroid, nonsteroidal anti-inflammatory drug, or colchicine and on not initiating long-term urate-lowering therapy (ULT) for most patients after a first gout attack and in those whose attacks are infrequent (<2 per year). However, they differ on treatment of both recurrent gout and problematic gout...
December 4, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/30507064/the-contribution-of-ptpn22-to-rheumatological-disease
#9
REVIEW
Tomas Mustelin, Nunzio Bottini, Stephanie M Stanford
One of the unresolved questions in modern medicine is why certain individuals develop a disorder such as rheumatoid arthritis or lupus, while others do not. Contemporary science holds genetics partly responsible and blames the remainder on environmental and stochastic factors. Among the many genes that increase the risk of autoimmune conditions, the risk allele encoding the W620 variant of PTPN22 is shared between multiple rheumatologic diseases, suggesting a fundamental role in the development of immune dysfunction...
December 3, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/30506466/advances-in-rheumatology-practice-in-brazil
#10
REVIEW
Francisco Airton Castro Rocha, Joaquim Ivo Vasques Dantas Landim, Leila Nascimento da Rocha
Despite resilient inequities, Brazil has seen progressive improvement in health care in the last 25 years. Infectious diseases rendered place to chronic non-communicable diseases as a major cause of death. Existence of traditional schools of medicine and training services in rheumatology helped form a reasonable number of specialists, though irregular distribution due to the economic issues favoring their clustering in major cities. The Brazilian Society of Rheumatology provides continued medical education, helps training rheumatologists, family physicians and other health professionals and has worked to publish national recommendations for the diagnosis and treatment of major rheumatic diseases...
December 1, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30505014/hyperthermia-in-rheumatic-diseases-a-promising-approach
#11
REVIEW
Krzysztof Jeziorski
Hyperthermia is a method applied in the treatment of many diseases, including rheumatic diseases. There are relatively few reports concerning the role of that method in the treatment of these diseases, and most studies have not been randomised. Hyperthermia includes directed application of thermal energy. The aim of that therapy is to overcome the body's natural thermoregulation mechanism through application of external heat sources such as electromagnetic radiation of various frequencies, or ultrasound. Usually, temperatures are used within the 38...
2018: Reumatologia
https://www.readbyqxmd.com/read/30505013/differential-diagnosis-of-idiopathic-inflammatory-myopathies-in-adults-the-first-step-when-approaching-a-patient-with-muscle-weakness
#12
REVIEW
Piotr Szczęsny, Katarzyna Świerkocka, Marzena Olesińska
Despite its misleading adjective, the most commonly used diagnostic criteria of idiopathic inflammatory myopathies (IIM) are applicable only after all other non-autoimmune muscle diseases have been excluded. It makes differential diagnosis the first step when approaching a patient with muscle weakness. This article is designed to list the most common conditions from which to differentiate in rheumatological care. In fact, many patients with the diseases described here have been initially misdiagnosed with IIM...
2018: Reumatologia
https://www.readbyqxmd.com/read/30504507/smoking-is-associated-with-higher-disease-activity-in-rheumatoid-arthritis-a-longitudinal-study-controlling-for-time-varying-covariates
#13
Milena A Gianfrancesco, Laura Trupin, Stephen Shiboski, Mark van der Laan, Jonathan Graf, John Imboden, Jinoos Yazdany, Gabriela Schmajuk
OBJECTIVE: Prior studies around the relationship between smoking and rheumatoid arthritis (RA) disease activity have reported inconsistent findings, which may be ascribed to heterogeneous study designs or biases in statistical analyses. We examined the association between smoking and RA outcomes using statistical methods that account for time-varying confounding and loss to followup. METHODS: We included 282 individuals with an RA diagnosis using electronic health record data collected at a public hospital between 2013 and 2017...
December 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/30504479/statins-and-mortality-in-connective-tissue-diseases-should-we-resume-the-cardio-rheumatology-spirit-in-our-clinics
#14
EDITORIAL
Elisa Gremese, Enrico DE Lorenzis, Gianfranco F Ferraccioli
No abstract text is available yet for this article.
December 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/30504326/the-rheumatology-hematology-interface-caps-and-mas-diagnosis-and-management
#15
REVIEW
John M Gansner, Nancy Berliner
Catastrophic antiphospholipid antibody syndrome (CAPS) and macrophage activation syndrome (MAS) are both life-threatening hematologic disorders that infrequently afflict patients with rheumatologic disease. CAPS is characterized by fulminant multiorgan damage related to small vessel thrombosis in the setting of persistent antiphospholipid antibodies. It can occur in patients with rheumatologic diseases such as systemic lupus erythematosus but can also affect patients who do not have rheumatologic disease. By contrast, the term MAS is applied when patients with rheumatologic disease develop hemophagocytic lymphohistiocytosis (HLH); therefore, patients with MAS have an underlying rheumatologic disease by definition...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30501823/expression-analysis-of-matrix-metalloproteinase-9-gene-in-rheumatoid-arthritis-patients-on-disease-modifying-anti-rheumatic-drugs
#16
Farzana Hakim, Amir Rashid, Amer Fakhr, Saleem Ahmed Khan
OBJECTIVE: To evaluate matrix metalloproteinase-9 gene expression in rheumatoid arthritis patients on disease modifying anti-rheumatic agents with the objective to further modify the current treatment regimen if indicated in order to prevent progression to deforming rheumatoid arthritis. STUDY DESIGN: Cross-sectional comparative study. PLACE AND DURATION OF STUDY: CREAM Lab (Centre for Research in Experimental and Applied Medicine) and Department of Biochemistry and Molecular Biology, Army Medical College, in collaboration with Rheumatology Department at Military Hospital Rawalpindi from November 2015 to November 2016...
December 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/30500268/sensitivity-specificity-and-reliability-of-the-get-active-questionnaire-for-identifying-children-with-medically-necessary-special-considerations-for-physical-activity
#17
Patricia E Longmuir, Julia Jackson, Emily Ertel, Maala Bhatt, Asif Doja, Ciaran Duffy, Letizia Gardin, Roman Jurencak, Sherri Lynne Katz, Lillian Lai, Christine Lamontagne, Suzie Lee, Jane Lougheed, Anna McCormick, Hugh J McMillan, Daniela Pohl, Johannes Roth, Carol Theoret-Douglas, Karen Watanabe Duffy, Derek Wong, Roger Zemek
Physical activity is promoted for optimal health but may carry risks for children who require medically necessary activity restrictions. The sensitivity, specificity and reliability of the Get Active Questionnaire (GAQ) for identifying children needing special considerations during physical activity was evaluated among parents of 207 children, 3 to 14 years of age (97 (47%) female, mean age of 8.4±3.7 years). GAQ responses were compared to reports obtained directly from the treating physician (n=192/207) and information in the medical chart (clinic notes/physician letter, n=111/207)...
November 30, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/30499418/combination-therapy-of-apremilast-and-biologic-agent-as-a-safe-option-of-psoriatic-arthritis-and-psoriasis
#18
Samy Metyas, Christopher Tomassian, Ramy Messiah, Tina Gettas, Christina Chen, Anne Quismorio
Psoriasis is a chronic immune-mediated inflammatory dermatologic condition that is often associated with psoriatic arthritis. There are multiple regimens for the treatment of psoriasis including disease modifying anti rheumatics drugs, biologic agents, phototherapy, topical retinoid and steroids creams, as well as apremilast. Apremilast is an oral phosphodiesterase inhibitor that was approved by the FDA in March 2014 for the treatment of psoriatic arthritis and September 2014 for the treatment of moderate to severe plaque psoriasis...
November 29, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/30499259/2018-american-college-of-rheumatology-national-psoriasis-foundation-guideline-for-the-treatment-of-psoriatic-arthritis
#19
Jasvinder A Singh, Gordon Guyatt, Alexis Ogdie, Dafna D Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J Mease, Joseph F Merola, Julie Miner, Christopher T Ritchlin, Bernadette Siaton, Benjamin J Smith, Abby S Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C Coates, Alice Gottlieb, Marina Magrey, W Benjamin Nowell, Ana-Maria Orbai, Soumya M Reddy, Jose U Scher, Evan Siegel, Michael Siegel, Jessica A Walsh, Amy S Turner, James Reston
OBJECTIVE: To develop an evidence-based guideline for the pharmacologic and nonpharmacologic treatment of psoriatic arthritis (PsA), as a collaboration between the American College of Rheumatology (ACR) and the National Psoriasis Foundation (NPF). METHODS: We identified critical outcomes in PsA and clinically relevant PICO (population/intervention/comparator/outcomes) questions. A Literature Review Team performed a systematic literature review to summarize evidence supporting the benefits and harms of available pharmacologic and nonpharmacologic therapies for PsA...
November 30, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/30499246/2018-american-college-of-rheumatology-national-psoriasis-foundation-guideline-for-the-treatment-of-psoriatic-arthritis
#20
Jasvinder A Singh, Gordon Guyatt, Alexis Ogdie, Dafna D Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J Mease, Joseph F Merola, Julie Miner, Christopher T Ritchlin, Bernadette Siaton, Benjamin J Smith, Abby S Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C Coates, Alice Gottlieb, Marina Magrey, W Benjamin Nowell, Ana-Maria Orbai, Soumya M Reddy, Jose U Scher, Evan Siegel, Michael Siegel, Jessica A Walsh, Amy S Turner, James Reston
OBJECTIVE: To develop an evidence-based guideline for the pharmacologic and nonpharmacologic treatment of psoriatic arthritis (PsA), as a collaboration between the American College of Rheumatology (ACR) and the National Psoriasis Foundation (NPF). METHODS: We identified critical outcomes in PsA and clinically relevant PICO (population/intervention/comparator/outcomes) questions. A Literature Review Team performed a systematic literature review to summarize evidence supporting the benefits and harms of available pharmacologic and nonpharmacologic therapies for PsA...
November 30, 2018: Arthritis & Rheumatology
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