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Left ventricular hypertrophy

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https://www.readbyqxmd.com/read/29334670/genetic-ablation-of-trpv1-exacerbates-pressure-overload-induced-cardiac-hypertrophy
#1
Beihua Zhong, Jack Rubinstein, Shuangtao Ma, Donna H Wang
Transient receptor potential vanilloid 1 (TRPV1) channels expressed in sensory nerves may regulate vascular tone and cardiovascular function via their anti-inflammatory effects by releasing neuropeptide calcitonin gene-related peptide (CGRP). Inflammation plays a role in the progression of cardiac hypertrophy and TRPV1 activation may be key to cardiac inflammatory processes. The aim of this study was to test the hypothesis that TRPV1 modulates inflammatory processes to protect the heart from pressure overload-induced hypertrophy and inflammatory responses...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29332066/correlation-between-serum-calcineurin-activity-and-left-ventricular-hypertrophy-in-hypertensive-patients-and-its-clinical-significance
#2
Jia-Li Cao, Yu-Qing Yang, Dookhun Muhammad Nabeel, Ya-Li Sun, Hua-Yi-Yang Zou, Xiang-Qing Kong, Xin-Zheng Lu
OBJECTIVE: The aim of this study is to investigate the correlation between calcineurin (CaN) and hypertension with left ventricular hypertrophy (HLVH) and to evaluate its potential clinical significance. DESIGN: The study involved 160 patients diagnosed with hypertension and 42 controls. Based on the exclusion criteria, 42 were not eligible for this study. The remaining 118 hypertensive patients were categorized into 2 subgroups based on left ventricular mass index and relative ventricular wall thickness: a normal model subgroup with hypertension (HNM) and an HLVH subgroup...
January 13, 2018: Cardiology
https://www.readbyqxmd.com/read/29330420/left-ventricular-hypertrophy-and-cognitive-function-a-systematic-review
#3
C Restrepo, S K Patel, V Rethnam, E Werden, J Ramchand, L Churilov, L M Burrell, A Brodtmann
Cognitive impairment is common in patients with hypertension. Left ventricular hypertrophy (LVH) is recognised as a marker of hypertension-related organ damage and is a strong predictor of coronary artery disease, heart failure and stroke. There is evidence that LVH is independently associated with cognitive impairment, even after adjustment for the presence of hypertension. We conducted a systematic review that examined cognitive impairment in adults with LVH. Independent searches were performed in Ovid MEDLINE, Ovid psycInfo and PubMed with the terms left ventricular hypertrophy and cognition...
January 12, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29328372/differential-microrna-expression-profiles-and-bioinformatics-analysis-between-young-and-aging-spontaneously-hypertensive-rats
#4
Jingfeng Wang, Jingjing Zhang, Xuefeng Ding, Yanyan Wang, Zhiming Li, Weipeng Zhao, Jianguo Jia, Jingmin Zhou, Junbo Ge
MicroRNAs (miRNAs/miRs) serve a role as important regulators in cardiac hypertrophy. The present study aimed to reveal the differential expression profile of miRNAs between young and aging spontaneously hypertensive rats (SHRs) and studied the functional annotation of predicted targets. Briefly, 3‑month‑old and 12‑month‑old SHRs (n=3/group) were subjected to echocardiography, histopathological analysis and dihydroethidium staining. Subsequently, small RNA sequencing and data processing was conducted to identify the differentially expressed miRNAs between these two groups...
January 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29327381/oxidative-stress-impairs-myocyte-autophagy-resulting-in-myocyte-hypertrophy
#5
Jia-Pu Wang, Rui-Fang Chi, Ke Wang, Teng Ma, Xiao-Fei Guo, Xiao-Li Zhang, Bao Li, Fu-Zhong Qin, Xue-Bin Han, Bian-Ai Fan
Insufficient or excessive myocyte autophagy is associated with left ventricular (LV) hypertrophy. Reactive oxygen species mediate myocyte hypertrophy in vitro and pressure overload-induced LV hypertrophy in vivo. In the present study, we tested the hypothesis that oxidative stress induces autophagy impairment that results in myocyte hypertrophy. H9C2 cardiomyocytes were exposed to 10 and 50 μm hydrogen peroxide (H2 O2 ) for 48 h pretreated with autophagy inhibitor 3-methyladenine (3-MA). Male Sprague-Dawley rats underwent abdominal aortic constriction (AAC) or sham operation...
January 12, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29325918/bioactive-fraction-of-rhodiola-algida-against-chronic-hypoxia-induced-pulmonary-arterial-hypertension-and-its-anti-proliferation-mechanism-in-rats
#6
Xingmei Nan, Shanshan Su, Ke Ma, Xiaodong Ma, Ximeng Wang, Dongzhu Zhaxi, Rili Ge, Zhanqiang Li, Dianxiang Lu
BACKGROUND: Rhodiola algida has long been used to prevent acute and chronic altitude sickness. In our previous study, we screened for a bioactive fraction from R. algida. However, the effects and mechanisms of this bioactive fraction on chronic hypoxia-induced pulmonary arterial hypertension remain to be elucidated. OBJECTIVE: The aim of this study was to determine the effect of bioactive fraction from R. algida (ACRT) on chronic hypoxia-induced pulmonary arterial hypertension (HPAH) and to understand the possible mechanism of its pharmacodynamic actions...
January 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29325129/transaortic-septal-myectomy-using-direct-septal-echography
#7
Kanji Matsuzaki, Toru Tsukada, Masataka Sato, Yasunori Watanabe
We applied direct septal echography in transaortic septal myectomy for left ventricular outflow tract obstruction due to hypertrophic obstructive cardiomyopathy and asymmetric septal hypertrophy. A small L-shaped probe was inserted into the right ventricle through a 2-cm incision on the right ventricular outflow tract. The probe was placed directly on the interventricular septum to visualize its actual thickness. It was also helpful to push and expose the septum into a direct field of vision through the aortic annulus...
January 8, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29324968/long-term-effects-of-an-intensive-lifestyle-intervention-on-electrocardiographic-criteria-for-left-ventricular-hypertrophy-the-look-ahead-trial
#8
Tina E Brinkley, Andrea Anderson, Elsayed Z Soliman, Alain G Bertoni, Frank Greenway, William C Knowler, Stephen P Glasser, Edward S Horton, Mark A Espeland
Background: Left ventricular hypertrophy assessed by electrocardiography (ECG-LVH) is a marker of subclinical cardiac damage and a strong predictor of cardiovascular disease (CVD) events. The prevalence of ECG-LVH is increased in obesity and type 2 diabetes; however, there are no data on the long-term effects of weight loss on ECG-LVH. The purpose of this study was to determine whether an intensive lifestyle intervention reduces ECG-LVH in overweight and obese adults with type 2 diabetes...
January 9, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29323059/histological-and-morphometric-analysis-of-dilated-cardiomyopathy-with-special-reference-to-collagen-iv-expression
#9
Parul Jain, Sudheer Arava, Sandeep Seth, Sanjeev Lalwani, Ruma Ray
INTRODUCTION: Collagen distribution alterations are well known in dilated cardiomyopathy. There are also changes in microvasculature along with other histomorphorphological features. AIMS AND OBJECTIVES: To study the histomorphological features of DCM along with their quantitative correlation with LVEF. Alterations in collagen IV distribution pattern and microvasculature in DCM were also evaluated. MATERIALS AND METHODS: The present study includes 34 right ventricular endomyocardial biopsies, 7 explanted native hearts and 41 autopsy control hearts...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29322433/biological-aortic-valve-replacement-advantages-and-optimal-indications-of-stentless-compared-to-stented-valve-substitutes-a-review
#10
REVIEW
Reza Tavakoli, Pichoy Danial, Ahmed Hamid Oudjana, Peiman Jamshidi, Max Gassmann, Pascal Leprince, Guillaume Lebreton
Controversy still surrounds the optimal biological valve substitute for aortic valve replacement. In light of the current literature, we review advantages and optimal indications of stentless compared to stented aortic bio-prostheses. Recent meta-analyses, prospective randomized controlled trials and retrospective studies comparing the most frequently used stentless and stented aortic bio-prostheses were analyzed. In the present review, the types and implantation techniques of the bio-prosthesis that are seldom taken into account by most studies and reviews were integrated in the interpretation of the relevant reports...
January 10, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29319402/interaction-of-metabolic-health-and-obesity-on-subclinical-target-organ-damage
#11
Hyun-Jung Lee, Hack-Lyoung Kim, Jaehoon Chung, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim
BACKGROUND: Metabolically healthy obese (MHO) individuals generally show better cardiovascular prognosis compared with metabolically unhealthy counterparts, which may be related to different patterns of target organ damage (TOD). We aimed to investigate the patterns of TOD related to obesity and metabolic unhealthiness. METHODS: A total of 659 Korean adults (mean age, 60.0 ± 11.8 years; male, 51.1%) undergoing health examinations were stratified into four groups according to obesity (body mass index ≥25...
January 10, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29319343/obesity-and-sudden-cardiac-death-in-the-young-clinical-and-pathological-insights-from-a-large-national-registry
#12
Gherardo Finocchiaro, Michael Papadakis, Harshil Dhutia, Della Cole, Elijah R Behr, Maite Tome, Sanjay Sharma, Mary N Sheppard
Aims Obesity is an increasing public health problem and a risk factor for cardiovascular diseases. The aim of the study was to determine the main features and aetiologies in a large cohort of sudden cardiac deaths that occurred in obese subjects. Methods Between 1994 and 2014, 3684 consecutive cases of unexpected sudden cardiac death were referred to our cardiac pathology centre. This study was confined to young individuals (age ≤ 35 years) for whom information about body mass index was available and consisted of 1033 cases...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29318960/the-role-of-inflammation-in-epicardial-adipose-tissue-in-heart-diseases
#13
Zdenek Matloch, Anna Cinkajzlova, Milos Mraze, Martin Haluzik
Epicardial adipose tissue is not only a specific adipose tissue depot but also an active endocrine organ producing numerous substances with an important role in the development of obesity-related heart diseases. It is located between myocardium and visceral pericardium and consists predominantly of adipocytes, immunocompetent cells, ganglia and interconnecting nerve branches. Several studies documented a positive correlation between pericardial and epicardial fat and left ventricular hypertrophy and septal thickening, leading to diastolic dysfunction, electrocardiographic abnormalities and facilitating cardiac failure...
January 9, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29318851/-effect-of-combined-intervention-of-electroacupuncture-and-astragaloside-iv-on-myocardial-hypertrophy-and-tgf-%C3%AE-1-smad-signaling-in-rats-with-myocardial-fibrosis
#14
Jia-Shen Li, Xiao-Yu Zhu, Mei-Li Lu, Jun-Hong Gao, Hong-Xin Wang, Xiao-Chun Yu
OBJECTIVE: To observe the effect of combined intervention of electroacupuncture (EA) and astragaloside IV(ASIV) on cardiac hypertrophy and transforming growth factor β 1 (TGF-β 1)/Smad signaling in isoproterenol (ISO) induced cardiac hypertrophy rats, so as to investigate its underlying mechanisms in improving myocardial fibrosis. METHODS: A total of 50 SD rats were randomly divided into 5 groups: normal control, model (ISO), Propranolol (PRO),ASIV and EA+ASIV groups (n=10 in each group)...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29315085/biopsy-confirmed-endothelial-cell-activation-in-patients-with-coronary-microvascular-dysfunction
#15
Hannes Lindemann, Ivana Petrovic, Stephan Hill, Anastasios Athanasiadis, Heiko Mahrholdt, Tim Schäufele, Karin Klingel, Udo Sechtem, Peter Ong
BACKGROUND: Patients with angina yet having unobstructed coronaries are found in ∼50% of cases undergoing invasive angiography. Coronary spasm and microvascular dysfunction can be responsible for the clinical presentation in ∼60% of cases. However, little is known about structural changes in the myocardium. The aim of this study was to describe findings in endomyocardial biopsies of symptomatic patients with unobstructed coronaries. PATIENTS AND METHODS: We retrospectively analyzed a cohort of 1416 consecutive patients who underwent endomyocardial biopsy sampling and coronary angiography between 2002 and 2016 for various clinical indications...
January 8, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29313298/dimensions-of-and-responses-to-perceived-discrimination-and-subclinical-disease-among-african-americans-in-the-jackson-heart-study
#16
Victoria I Okhomina, LáShauntá Glover, Herman Taylor, Mario Sims
BACKGROUND: Although discrimination among African Americans (AAs) has been linked to various health outcomes, few studies have examined associations of multiple measures of discrimination with prevalent subclinical disease in a large sample of AAs. OBJECTIVES: To examine the associations of measures of discrimination and coping responses to discrimination with prevalent subclinical disease among AAs in the Jackson Heart Study (JHS); and whether this association is modified by sex...
January 8, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29313136/klotho-g-395a-gene-polymorphism-impact-on-progression-of-end-stage-renal-disease-and-development-of-cardiovascular-complications-in-children-on-dialysis
#17
Eman A Elghoroury, Fatina I Fadel, Manal F Elshamaa, Dina Kandil, Doaa M Salah, Marwa M El-Sonbaty, Hebatallah Farouk, Mona Raafat, Soha Nasr
BACKGROUND: Klotho G-395-A gene polymorphism may impact children with end-stage renal disease (ESRD). We investigated the relevance of Klotho G-395-A on ESRD development and progression, and its relationship with evolution of cardiovascular complications in pediatric dialysis patients. METHODS: Fifty-five children with chronic kidney disease (CKD) and seventy healthy children were genotyped for Klotho G-395A. RESULTS: Incidence of GA/AA genotypes and A allele were higher in ESRD patients compared with controls (54...
January 8, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29311519/left-ventricular-mass-influences-relationship-between-filling-pressure-and-early-diastolic-ratio-of-inflow-velocity-to-mitral-annular-velocity-e-e
#18
Masahiro Nakabachi, Satoshi Yamada, Hiroyuki Iwano, Taichi Hayashi, Kazunori Okada, Kenya Kusunose, Kiyotaka Watanabe, Tomoko Ishizu, Kazuaki Wakami, Hirotsugu Yamada, Kaoru Dohi, Yoshihiro Seo, Nobuyuki Ohte, Chikara Shimizu, Taisei Mikami
BACKGROUND: Early-diastolic mitral annular velocity (e') and the ratio of early-diastolic left ventricular (LV) inflow velocity (E) to e' (E/e') have been widely used as indexes of LV relaxation and filling pressure, respectively. However, many recent studies have demonstrated that they are not reliable in various clinical settings. We thus investigated the factors influencing these echocardiographic parameters in a multicenter study.Methods and Results:The study group comprised 69 patients, referred for cardiac catheterization, and enrolled in 5 university hospitals...
December 29, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29309658/genetic-background-influences-cardiac-phenotype-in-murine-chronic-kidney-disease
#19
Samantha Neuburg, Corey Dussold, Claire Gerber, Xueyan Wang, Connor Francis, Lixin Qi, Valentin David, Myles Wolf, Aline Martin
Background: Levels of fibroblast growth factor 23 (FGF23) increase early in chronic kidney disease (CKD) and are independently associated with left ventricular hypertrophy (LVH), heart failure and death. Experimental models of CKD with elevated FGF23 and LVH are needed. We hypothesized that slow rates of CKD progression in the Col4a3 knockout (Col4a3KO) mouse model of CKD would promote development of LVH by prolonging exposure to elevated FGF23. Methods: We studied congenic Col4a3KO and wild-type (WT) mice with either 75% 129X1/SvJ (129Sv) or 94% C57Bl6/J (B6) genomes...
December 22, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29306449/chronic-exercise-induces-pathological-left-ventricular-hypertrophy-in-adrenaline-deficient-mice
#20
Priscila Mendes, Raquel Martinho, Sara Leite, Leonardo Maia-Moço, Adelino F Leite-Moreira, André P Lourenço, Mónica Moreira-Rodrigues
Adrenaline-deficient phenylethanolamine-N-methyltransferase-knockout mice (Pnmt-KO) have concentric heart remodeling and though their resting blood pressure is normal, it becomes higher during acute exercise. The aim of this study was to evaluate cardiac morphological, functional and molecular alterations after chronic exercise in adrenaline-deficient mice. Genotypes at the Pnmt locus were verified by polymerase chain reaction (PCR) of ear samples of Pnmt-KO and wild-type (WT) mice. These mice were submitted to chronic exercise training during 6weeks...
February 15, 2018: International Journal of Cardiology
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