Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Alison Laws, Saskia Leonard, Emma Hershey, Samantha Stokes, Julie Vincuilla, Eshita Sharma, Kara Milliron, Judy E Garber, Sofia D Merajver, Tari A King, Melissa L Pilewskie
No abstract text is available yet for this article.
February 16, 2024: Annals of Surgical Oncology
#22
REVIEW
Tari Haahtela, Jean Bousquet, Josep M Antó
Nature (biodiversity) loss is the loss or decline of the state of nature taking place in the wider environment. We present a novel concept, nature deficiency, referring to nature loss in the human body influencing health. Humans are connected with the natural environment and its microbes and biogenic chemicals through eating (drinking), breathing, and touching. The mental and sociocultural links to the environment are also strong. With medical and ecological research and guidelines, the diagnosis, prevention, and treatment of nature deficiency may become part of the clinical practice...
2024: Porto Biomedical Journal
#23
JOURNAL ARTICLE
Bernardo Sousa-Pinto, Arunas Valiulis, Erik Melén, Gerard H Koppelman, Nikolaos G Papadopoulos, Mika Makela, Tari Haahtela, Matteo Bonini, Fulvio Braido, Luisa Brussino, Alvaro A Cruz, Alessandro Fiocchi, Mattia Giovannini, Bilun Gemicioglu, Marek Kulus, Piotr Kuna, Maciej Kupczyk, Violeta Kvedariene, Désirée E Larenas-Linnemann, Renaud Louis, Mario Morais-Almeida, Marek Niedoszytko, Markus Ollert, Oliver Pfaar, Frederico S Regateiro, Graham Roberts, Boleslaw Samolinski, Marine Savouré, Luis Taborda-Barata, Sanna Toppila-Salmi, Maria Teresa Ventura, Marta Vazquez-Ortiz, Rafael José Vieira, Joao A Fonseca, Arzu Yorgancioglu, Torsten Zuberbier, Josep M Anto, Jean Bousquet, Nhân Pham-Thi
BACKGROUND: In allergic rhinitis and asthma, adolescents and young adult patients are likely to differ from older patients. We compared adolescents, young adults and adults on symptoms, control levels, and medication adherence. METHODS: In a cross-sectional study (2015-2022), we assessed European users of the MASK-air mHealth app of three age groups: adolescents (13-18 years), young adults (18-26 years), and adults (>26 years). We compared them on their reported rhinitis and asthma symptoms, use and adherence to rhinitis and asthma treatment and app adherence...
February 2024: Pediatric Allergy and Immunology
#24
REVIEW
Chrysanthi Skevaki, Kari C Nadeau, Marc E Rothenberg, Barrak Alahmad, Blandina T Mmbaga, Gileard G Masenga, Vanitha Sampath, David C Christiani, Tari Haahtela, Harald Renz
Climate change is not just jeopardizing the health of our planet, but it is increasingly impacting our immune health. There is an expanding body of evidence that climate-related exposures, such as air pollution, heat, wildfires, extreme weather events, and biodiversity loss significantly disrupt the functioning of the human immune system. These exposures manifest in a broad range of stimuli including antigens, allergens, heat stress, pollutants, microbiota changes, and other toxic substances. Such exposures pose a direct and indirect threat to our body's primary line of defense, the epithelial barrier, affecting its physical integrity and functional efficacy...
February 1, 2024: Journal of Allergy and Clinical Immunology
#25
JOURNAL ARTICLE
Eugene Yip, Shima Y Tari, Michael W Reynolds, David Sinn, Brad R Murray, B Gino Fallone, Patricia Ak Oliver
BACKGROUND: The world's first clinical 0.5 T inline rotating biplanar Linac-MR system is commissioned for clinical use. For reference dosimetry, unique features to device, including an SAD = 120 cm, bore clearance of 60 cm × 110 cm, as well as 0.5 T inline magnetic field, provide some challenges to applying a standard dosimetry protocol (i.e., TG-51). PURPOSE: In this work, we propose a simple and practical clinical reference dosimetry protocol for the 0...
February 3, 2024: Medical Physics
#26
JOURNAL ARTICLE
Zheqi Li, Otto Metzger Filho, Giuseppe Viale, Patrizia dell'Orto, Leila Russo, Marie-Anne Goyette, Avni Kamat, Denise A Yardley, Vandana Gupta Abramson, Carlos L Arteaga, Laura M Spring, Kami Chiotti, Carol Halsey, Adrienne G Waks, Tari A King, Susan C Lester, Jennifer R Bellon, Eric P Winer, Paul T Spellman, Ian E Krop, Kornelia Polyak
BACKGROUND: HER2-targeting therapies have great efficacy in HER2-positive breast cancer, but resistance in part due to HER2 heterogeneity (HET) is a significant clinical challenge. We previously described that in a phase II neoadjuvant trastuzumab emtansine (T-DM1) and pertuzumab (T-DM1+P) clinical trial in early-stage HER2-positive breast cancer, none of the patients with HER2-HET tumors had pathologic complete response (pCR). METHODS: To investigate cellular and molecular differences among tumors according to HER2 heterogeneity and pCR, we performed RNA sequencing (RNA-seq) and ERBB2 FISH of 285 pre/post-treatment tumors from 129 patients in this T-DM1+P neoadjuvant trial...
February 1, 2024: Journal of Clinical Investigation
#27
RANDOMIZED CONTROLLED TRIAL
Filipa Lynce, Laura E Stevens, Zheqi Li, Jane E Brock, Anushree Gulvady, Ying Huang, Faina Nakhlis, Ashka Patel, Jeremy M Force, Tufia C Haddad, Naoto Ueno, Vered Stearns, Antonio C Wolff, Amy S Clark, Jennifer R Bellon, Edward T Richardson, Justin M Balko, Ian E Krop, Eric P Winer, Paulina Lange, E Shelley Hwang, Tari A King, Sara M Tolaney, Alastair Thompson, Gaorav P Gupta, Elizabeth A Mittendorf, Meredith M Regan, Beth Overmoyer, Kornelia Polyak
BACKGROUND: Patients with inflammatory breast cancer (IBC) have overall poor clinical outcomes, with triple-negative IBC (TN-IBC) being associated with the worst survival, warranting the investigation of novel therapies. Preclinical studies implied that ruxolitinib (RUX), a JAK1/2 inhibitor, may be an effective therapy for TN-IBC. METHODS: We conducted a randomized phase II study with nested window-of-opportunity in TN-IBC. Treatment-naïve patients received a 7-day run-in of RUX alone or RUX plus paclitaxel (PAC)...
January 31, 2024: Breast Cancer Research: BCR
#28
EDITORIAL
Daniele Ugo Tari
Breast cancer (BC) is the most prevalent form of cancer among women worldwide, accounting for over 2 million diagnoses annually [...].
January 22, 2024: Current Oncology
#29
JOURNAL ARTICLE
Tessa Higgins, Olga Kantor, Beth Harrison, Julia Giordano, Monica McGrath, Harold J Burstein, Stuart J Schnitt, Tasnim Rahman, Halley Vora, Ana Garrido-Castro, Sara M Tolaney, Funda Meric-Bernstam, Tari A King, Elizabeth A Mittendorf
No abstract text is available yet for this article.
January 24, 2024: Annals of Surgical Oncology
#30
JOURNAL ARTICLE
Alison Laws, Saskia Leonard, Emma Hershey, Samantha Stokes, Julie Vincuilla, Eshita Sharma, Kara Milliron, Judy E Garber, Sofia D Merajver, Tari A King, Melissa L Pilewskie
BACKGROUND: High-risk lesions (HRL) of the breast are risk factors for future breast cancer development and may be associated with a concurrent underlying malignancy when identified on needle biopsy; however, there are few data evaluating HRLs in carriers of germline pathogenic variants (PVs) in breast cancer predisposition genes. METHODS: We identified patients from two institutions with germline PVs in high- and moderate-penetrance breast cancer predisposition genes and an HRL in an intact breast, including atypical ductal hyperplasia (ADH), flat epithelial atypia (FEA), and lobular neoplasia (LN)...
January 23, 2024: Annals of Surgical Oncology
#31
JOURNAL ARTICLE
Bekele Tesfaye Meteku, Matthew Quigley, Tari Turner, Sally E Green
INTRODUCTION: Living guidelines provide reliable, ongoing evidence surveillance and regularly updated recommendations for healthcare decision-making. As a relatively new concept, most of the initial application of living approaches has been undertaken in high-income countries. However, in this scoping review, we looked at what is currently known about how living guidelines were developed, used and applied in low-income and middle-income countries. METHODS: Searches for published literature were conducted in Medline, Global Health, Cochrane Library and Embase...
January 17, 2024: BMJ Open
#32
REVIEW
Yashar Vaziri
Chronic obstructivе pulmonary disеasе (COPD), a rеspiratory disеasе, is influenced by a combination of gеnеtic and еnvironmеntal factors. Thе fiеld of nutrigеnomics, which studiеs thе intеrplay bеtwееn diеt and gеnеs, provides valuable insights into thе gеnomic landscapе of COPD and its implications for production and managеmеnt. This rеviеw providеs a comprеhеnsivе ovеrviеw of thе gеnеtic aspеcts of COPD and thе rolе of nutrigеnomics in advancing our undеrstanding of thе undеrlying mеchanisms...
February 2024: Clinical Nutrition ESPEN
#33
JOURNAL ARTICLE
Alison Laws, Mirelle Lagendijk, Samantha Grossmith, Melissa Hughes, Nancy U Lin, Elizabeth A Mittendorf, A Heather Eliassen, Tari A King, Laura S Dominici
No abstract text is available yet for this article.
January 11, 2024: Annals of Surgical Oncology
#34
JOURNAL ARTICLE
Tari-Ann Yates, Ramya Vijayakumar, Martha McGilvray, Ali J Khiabani, Nicholas Razo, Laurie Sinn, Matthew R Schill, Nassir Marrouche, Christian Zemlin, Ralph J Damiano
OBJECTIVES: The mechanism by which mitral valve (MV) disease leads to atrial fibrillation (AF) remains poorly understood. Delayed-enhancement cardiac magnetic resonance imaging (DE-MRI) has been used to assess left atrial (LA) fibrosis in patients with lone AF before catheter ablation; however, few studies have used DE-MRI to assess MV-induced LA fibrosis in patients with or without AF undergoing MV surgery. METHODS: Between March 2018 and September 2022, 38 subjects were enrolled; 15 age-matched controls, 14 patients with lone mitral regurgitation (MR), and 9 patients with MR and AF (MR + AF)...
December 2023: JTCVS open
#35
JOURNAL ARTICLE
Tariful Islam, Shane Scoggin, Xiaoxia Gong, Masoud Zabet-Moghaddam, Nishan S Kalupahana, Naima Moustaid-Moussa
The plant-derived polyphenol curcumin alleviates the inflammatory and metabolic effects of obesity, in part, by reducing adipose tissue inflammation. We hypothesized that the benefits of curcumin supplementation on diet-induced obesity and systemic inflammation in mice occur through downregulation of white adipose tissue (WAT) inflammation. The hypothesis was tested in adipose tissue from high-fat diet-induced obese mice supplemented with or without curcumin and in 3T3-L1 adipocytes treated with or without curcumin...
December 25, 2023: Nutrients
#36
JOURNAL ARTICLE
Nicolas Taris, Elisabeth Luporsi, Marine Osada, Marie Thiblet, Carole Mathelin
OBJECTIVES: Breast oncology genetics emerged almost 30 years ago with the discovery of the BRCA1 and BRCA2 genes. The evolution of analytical practices has progressively allowed access to tests whose results now have a considerable impact on the management of both female and male breast cancers.The Sénologie Commission of the Collège National des Gynécologues et Obstétriciens Français (CNGOF) asked five specialists in breast surgery, oncology and oncological genetics to draw up a summary of the oncogenetic testing criteria used and the clinical implications for the female and male population of the test results, with or without an identified causal variant...
January 6, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
#37
JOURNAL ARTICLE
Stefania Morganti, Christopher J Gibson, Qingchun Jin, Katheryn Santos, Ashka Patel, Alex Wilson, Margaret Merrill, Julie Vincuilla, Samantha Stokes, Marla Lipsyc-Sharf, Tonia Parker, Tari A King, Elizabeth A Mittendorf, Giuseppe Curigliano, Melissa E Hughes, Daniel G Stover, Sara M Tolaney, Lachelle D Weeks, Nabihah Tayob, Nancy U Lin, Judy E Garber, Peter G Miller, Heather A Parsons
PURPOSE: Clonal hematopoiesis of indeterminate potential (CHIP) is frequent in patients with solid tumors. Prospective data about CHIP prevalence at breast cancer diagnosis and its dynamic evolution under treatment selective pressure are limited. PATIENTS AND METHODS: We performed targeted error-corrected sequencing on 614 samples from 380 patients with breast cancer. We investigated the dynamics of CHIP on prospectively collected paired samples from patients with early breast cancer (eBC) receiving chemotherapy (CT) or endocrine therapy (ET)...
January 8, 2024: Journal of Clinical Oncology
#38
JOURNAL ARTICLE
Nicola Lindson, Ailsa R Butler, Hayden McRobbie, Chris Bullen, Peter Hajek, Rachna Begh, Annika Theodoulou, Caitlin Notley, Nancy A Rigotti, Tari Turner, Jonathan Livingstone-Banks, Tom Morris, Jamie Hartmann-Boyce
BACKGROUND: Electronic cigarettes (ECs) are handheld electronic vaping devices which produce an aerosol by heating an e-liquid. People who smoke, healthcare providers and regulators want to know if ECs can help people quit smoking, and if they are safe to use for this purpose. This is a review update conducted as part of a living systematic review. OBJECTIVES: To examine the safety, tolerability and effectiveness of using electronic cigarettes (ECs) to help people who smoke tobacco achieve long-term smoking abstinence, in comparison to non-nicotine EC, other smoking cessation treatments and no treatment...
January 8, 2024: Cochrane Database of Systematic Reviews
#39
JOURNAL ARTICLE
Tessa Higgins, Olga Kantor, Beth Harrison, Julia Giordano, Monica McGrath, Harold J Burstein, Stuart J Schnitt, Tasnim Rahman, Halley Vora, Ana Garrido-Castro, Sara M Tolaney, Funda Meric-Bernstam, Tari A King, Elizabeth A Mittendorf
BACKGROUND: We sought to better define estrogen receptor-low-positive (ER-low+) breast cancer biology and determine the utility of the Oncotype DX Breast Recurrence Score® (RS) assay in this population. METHODS: Patients with information regarding percentage ER positivity and PAM50 subtype were identified in The Cancer Genome Atlas (TCGA) and subtype distribution was determined. Next, patients with ER-low+ (ER 1-10%), HER2- breast cancer undergoing upfront surgery with known RS result were identified in the National Cancer Database (NCDB) and our institutional Dana-Farber Brigham Cancer Center (DF/BCC) database; RS distribution was examined...
December 31, 2023: Annals of Surgical Oncology
#40
JOURNAL ARTICLE
Markus Mattila, Hanna-Mari Takkinen, Essi J Peltonen, Anna-Leena Vuorinen, Sari Niinistö, Johanna Metsälä, Suvi Ahonen, Mari Åkerlund, Leena Hakola, Jorma Toppari, Jorma Ilonen, Riitta Veijola, Tari Haahtela, Mikael Knip, Suvi M Virtanen
BACKGROUND: Prospective studies investigating the association between fruit, berry, and vegetable consumption and the risk of islet autoimmunity (IA) and type 1 diabetes (T1D) are few. OBJECTIVE: In this cohort study, we explored whether the consumption of fruits, berries, and vegetables is associated with the IA and T1D development in genetically susceptible children. METHODS: Food consumption data in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) cohort study was available from 5,674 children born between September 1996 and September 2004 in the Oulu and Tampere University Hospitals...
December 22, 2023: American Journal of Clinical Nutrition
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
