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Ioannis Bakolis, Richard Hooper, Claus Bachert, Bibi Lange, Tari Haahtela, Thomas Keil, Stephanie Hofmaier, Wytske Fokkens, Barbara Rymarczyk, Christer Janson, Peter G J Burney, Vanessa Garcia-Larsen
BACKGROUND: Dietary patterns defined using Principal Component Analysis (PCA) offer an alternative to the analysis of individual foods and nutrients and have been linked with asthma and allergic disease. However, results have not been reproducible in different settings. OBJECTIVE: To identify dietary patterns common to different European countries and examine their associations with asthma and allergic symptoms. METHODS: In sixteen study centres in nine European countries, 3206 individuals aged 15-77 years completed a common, internationally validated, Food Frequency Questionnaire and a respiratory symptoms questionnaire...
August 9, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Kelsey H Natsuhara, Katya Losk, Tari A King, Nancy U Lin, Kristen Camuso, Mehra Golshan, Stephen Pochebit, Jane E Brock, Craig A Bunnell, Rachel A Freedman
BACKGROUND: For clinically appropriate early-stage breast cancer patients, reflex criteria for Oncotype DX ordering ("the intervention") were implemented at our comprehensive cancer center, which reduced time-to-adjuvant chemotherapy initiation. Our objective was to evaluate Oncotype DX ordering practices and chemotherapy use before and after implementation of the intervention. MATERIALS AND METHODS: We examined medical records for 498 patients who had definitive breast cancer surgery at our center...
August 3, 2018: Oncologist
Yongfu Wang, Zulin Yu, Cori K Cahoon, Tari Parmely, Nancy Thomas, Jay R Unruh, Brian D Slaughter, R Scott Hawley
Biologists have long been fascinated with the organization and function of intricate protein complexes. Therefore, techniques for precisely imaging protein complexes and the location of proteins within these complexes are critically important and often require multidisciplinary collaboration. A challenge in these explorations is the limited resolution of conventional light microscopy. However, a new microscopic technique has circumvented this resolution limit by making the biological sample larger, thus allowing for super-resolution of the enlarged structure...
August 2018: Nature Protocols
Zhenrui Li, Pengxu Qian, Wanqing Shao, Hailing Shi, Xi C He, Madelaine Gogol, Zulin Yu, Yongfu Wang, Meijie Qi, Yunfei Zhu, John M Perry, Kai Zhang, Fang Tao, Kun Zhou, Deqing Hu, Yingli Han, Chongbei Zhao, Richard Alexander, Hanzhang Xu, Shiyuan Chen, Allison Peak, Kathyrn Hall, Michael Peterson, Anoja Perera, Jeffrey S Haug, Tari Parmely, Hua Li, Bin Shen, Julia Zeitlinger, Chuan He, Linheng Li
Transplantation of hematopoietic stem cells (HSCs) from human umbilical cord blood (hUCB) holds great promise for treating a broad spectrum of hematological disorders including cancer. However, the limited number of HSCs in a single hUCB unit restricts its widespread use. Although extensive efforts have led to multiple methods for ex vivo expansion of human HSCs by targeting single molecules or pathways, it remains unknown whether it is possible to simultaneously manipulate the large number of targets essential for stem cell self-renewal...
July 31, 2018: Cell Research
U Baran Metin, Maria C W Peeters, Toon W Taris
Occupational research often emphasizes the importance of workplace characteristics for understanding job stress and employee well-being, but the role of personal characteristics and having a good match with the job is mostly neglected. We explored how job crafting and feelings of being authentic at work were related to work engagement, work engagement of performance, and procrastination. A structural equation model analyzed self-reports from 380 Dutch office employees. Job crafting and authenticity were positively related to work engagement, and high work engagement predicted? better in-role and extra-role performance and less work procrastination...
July 2018: Journal of Prevention & Intervention in the Community
Hiroshi Goto, Masahiro Zako, Kenichi Namba, Noriyasu Hashida, Toshikatsu Kaburaki, Masanori Miyazaki, Koh-Hei Sonoda, Toshiaki Abe, Nobuhisa Mizuki, Koju Kamoi, Antoine P Brézin, Andrew D Dick, Glenn J Jaffe, Quan Dong Nguyen, Noritaka Inomata, Nisha V Kwatra, Anne Camez, Alexandra P Song, Martina Kron, Samir Tari, Shigeaki Ohno
PURPOSE: Report global adalimumab safety and efficacy outcomes in patients with non-infectious uveitis. METHODS: Adults with non-infectious intermediate, posterior, or panuveitis were randomized 1:1 to receive placebo or adalimumab in the VISUAL I (active uveitis) or VISUAL II (inactive uveitis) trials. Integrated global and Japan substudy results are reported. The primary endpoint was time to treatment failure (TF). RESULTS: In the integrated studies, TF risk was significantly reduced (hazard ratio [95% CI]) with adalimumab versus placebo (VISUAL I: HR = 0...
July 17, 2018: Ocular Immunology and Inflammation
Tara L Spivey, Emily D Gutowski, Nantthasorn Zinboonyahgoon, Tari A King, Laura Dominici, Rob R Edwards, Mehra Golshan, Kristin L Schreiber
BACKGROUND: Chronic pain is an important complication of breast surgery, estimated to affect 20-30% of patients. We prospectively examined surgical, demographic, and psychosocial factors associated with chronic pain 6 months after breast surgery. METHODS: Patients undergoing breast surgery for benign and malignant disease preoperatively completed validated questionnaires to assess baseline pain and psychosocial characteristics. Pain at 6 months was quantified as the Pain Burden Index (PBI), which encompasses pain locations, severity, and frequency...
July 16, 2018: Annals of Surgical Oncology
Anna Weiss, Tari A King, Kelly K Hunt, Elizabeth A Mittendorf
The American Joint Committee on Cancer staging system has evolved in response to improved imaging, refined surgical techniques, enhanced pathologic evaluation, and greater understanding of tumor biology. The 8th edition has introduced clinical and pathologic prognostic stages for breast cancer that incorporate biologic variables (grade, estrogen/progesterone receptor status, HER2 status, multigene panels) with TNM categories that define the anatomic stage. The prognostic staging system facilitates more refined stratification than the anatomic stage with respect to survival and is an important advance that maintains the clinical relevance of the staging system by taking into account tumor biology and current treatment algorithms...
August 2018: Surgical Clinics of North America
Tary Yin, Marie Jardine, Anna Miles, Jacqui Allen
PURPOSE: Structural and functional pharyngeal changes occur with age. How these affect swallowing in healthy older adults is not well defined. This study presents quantitative pharyngeal anatomic features in healthy adults using videofluoroscopic study of swallowing (VFSS). This will help our understanding of the normal changes in swallowing that occur with age and illustrate what may constitute normal variation compared with abnormal swallow function. METHODS: 138 mixed gender adults with no history of dysphagia were recruited and underwent a standardized VFSS protocol...
July 12, 2018: European Archives of Oto-rhino-laryngology
Tom G E Damen, Madelijn Strick, Toon W Taris, Henk Aarts
Research suggests that cognitive conflict is accompanied by a negative signal. Building on the demonstrated role of negative affect in attitude formation and change, the present research investigated whether the experience of cognitive conflict negatively influences subsequent evaluations of neutral stimuli. Relying on the emergence of conflict in the Stroop task, participants were presented with compatible (non-conflict) and incompatible (conflict) Stroop color words that were each followed by a neutral visual stimulus...
2018: PloS One
Ana Tari Ashizawa, Jenny Holt, Kelsey Faust, Weier Liu, Anjana Tiwari, Nan Zhang, Tetsuo Ashizawa
Cerebellar Purkinje cells (PCs) show conspicuous damages in many ataxic disorders. Targeted delivery of short nucleic acids, such as antisense oligonucleotides, to PCs may be a potential treatment for ataxic disorders, especially spinocerebellar ataxias (SCAs), which are mostly caused by a gain of toxic function of the mutant RNA or protein. However, oligonucleotides do not cross the blood-brain barrier (BBB), necessitating direct delivery into the central nervous system (CNS) through intra-thecal, intra-cisternal, intra-cerebral ventricular, or stereotactic parenchymal administration...
July 9, 2018: Cerebellum
Jean Baptiste Tary, Roberto Henry Herrera, Mirko van der Baan
The continuous wavelet transform (CWT) has played a key role in the analysis of time-frequency information in many different fields of science and engineering. It builds on the classical short-time Fourier transform but allows for variable time-frequency resolution. Yet, interpretation of the resulting spectral decomposition is often hindered by smearing and leakage of individual frequency components. Computation of instantaneous frequencies, combined by frequency reassignment, may then be applied by highly localized techniques, such as the synchrosqueezing transform and ConceFT, in order to reduce these effects...
August 13, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Skye P Barbic, Andrea A Jones, Melissa Woodward, Matt Piercy, Steve Mathias, Fidel Vila-Rodriguez, Olga Leonova, Geoffrey N Smith, Tari Buchanan, Alexandra T Vertinsky, Stephanie Gillingham, William J Panenka, Alexander Rauscher, Alasdair M Barr, Ric M Procyshyn, G William MacEwan, Donna J Lang, Allen E Thornton, Manraj K Heran, Adelena M Leon, Michael Krausz, William G Honer
OBJECTIVE: Young adults living in single room occupancy (SRO) hotels, a form of low-income housing, are known to have complex health and substance problems compared to their peers in the general population. The objective of this study is to comprehensively describe the mental, physical, and social health profile of young adults living in SROs. METHODS: This study reports baseline data from young adults aged 18-29 years, as part of a prospective cohort study of adults living in SROs in Vancouver, British Columbia, Canada...
April 2018: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
E Wallach, U Walther-Louvier, C Espil-Taris, F Rivier, E Baudou, C Cances
INTRODUCTION: Arthrogryposis is a descriptive term defining a sign. It describes a set of joint contractures, sometimes identifiable in utero, present from birth and nonprogressive. This term includes a heterogeneous group of diseases, of neurological, neuromuscular, genetic or mechanical origin. The common physiopathological mechanism is fetal immobility syndrome. Two types of classification have been developed: a clinical one (types I, II and III) and an etiological one. The main aim of this study was to define a standardized protocol for etiological investigation based on a descriptive analysis of the various etiologies identified in a population of children followed up for arthrogryposis...
June 15, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Graeme A King, Maryam Hashemi Shabestari, Kees-Karel H Taris, Ashutosh K Pandey, Sundararajan Venkatesh, Jayapalraja Thilagavathi, Kamalendra Singh, Rama Krishna Koppisetti, Dmitry Temiakov, Wouter H Roos, Carolyn K Suzuki, Gijs J L Wuite
Mitochondrial transcription factor A (TFAM) is essential for the maintenance, expression and transmission of mitochondrial DNA (mtDNA). However, mechanisms for the post-translational regulation of TFAM are poorly understood. Here, we show that TFAM is lysine acetylated within its high-mobility-group box 1, a domain that can also be serine phosphorylated. Using bulk and single-molecule methods, we demonstrate that site-specific phosphoserine and acetyl-lysine mimics of human TFAM regulate its interaction with non-specific DNA through distinct kinetic pathways...
April 20, 2018: Nucleic Acids Research
Masao Yamasaki, Kensaku Hamada, Kento Fujii, Kazuo Nishiyama, Yumi Yamasaki, Hiroyuki Tari, Kaori Araki, Teruaki Arakawa
Blueberry ( Vaccinium ashei ) leaf has recently attracted attention as an anti-obesity food component. In this study, we examined the effects of blueberry leaf extract (BLEx) on insulin signaling in C2C12 differentiated myoblasts. The results showed that BLEx promotes the intracellular uptake of 2-[ N -(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2- N BDG) and phosphorylation of Akt under insulin stimulation. In addition, pretreatment with BLEx ameliorated TNF-α-nduced insulin resistance with regard to 2-NBDG uptake and Akt phosphorylation...
July 2018: Biochemistry and Biophysics Reports
Samantha Grossmith, Anvy Nguyen, Jiani Hu, Jennifer K Plichta, Faina Nakhlis, Linda Cutone, Laura Dominici, Mehra Golshan, Margaret Duggan, Katharine Carter, Esther Rhei, Thanh Barbie, Katherina Calvillo, Suniti Nimbkar, Jennifer Bellon, Julia Wong, Rinaa Punglia, William Barry, Tari A King
BACKGROUND: The after mapping of the axilla: radiotherapy or surgery (AMAROS) trial concluded that for patients with cT1-2 N0 breast cancer and one or two positive sentinel lymph nodes (SLNs), axillary radiotherapy (AxRT) provides equivalent locoregional control and a lower incidence of lymphedema compared with axillary lymph node dissection (ALND). The study prospectively assessed how often ALND could be replaced by AxRT in a consecutive cohort of patients undergoing mastectomy for cT1-2 N0 breast cancer...
June 4, 2018: Annals of Surgical Oncology
Alan C Logan, Susan L Prescott, Tari Haahtela, David L Katz
In 1980, Jonas Salk (1914-1995) encouraged professionals in anthropology and related disciplines to consider the interconnections between "planetary health," sociocultural changes associated with technological advances, and the biology of human health. The concept of planetary health emphasizes that human health is intricately connected to the health of natural systems within the Earth's biosphere; experts in physiological anthropology have illuminated some of the mechanisms by which experiences in natural environments (or the built environment) can promote or detract from health...
June 4, 2018: Journal of Physiological Anthropology
Chaido Sirinian, Anastasios D Papanastasiou, Michail Schizas, Magda Spella, Georgios T Stathopoulos, Maria Repanti, Ioannis K Zarkadis, Tari A King, Haralabos P Kalofonos
The RANK/RANKL axis emerges as a key regulator of breast cancer initiation, progression, and metastasis. RANK-c is a RANK receptor isoform produced through alternative splicing of the TNFRSF11A (RANK) gene and a dominant-negative regulator of RANK-induced nuclear factor-κB (NF-κB) activation. Here we report that RANK-c transcript is expressed in 3.2% of cases in The Cancer Genome Atlas breast cancer cohort evenly between ER-positive and ER-negative cases. Nevertheless, the ratio of RANK to RANK-c (RANK/RANK-c) is increased in ER-negative breast cancer cell lines compared to ER-positive breast cancer cell lines...
May 29, 2018: Oncogene
Rafael Hernández-de-Diego, Sonia Tarazona, Carlos Martínez-Mira, Leandro Balzano-Nogueira, Pedro Furió-Tarí, Georgios J Pappas, Ana Conesa
The increasing availability of multi-omic platforms poses new challenges to data analysis. Joint visualization of multi-omics data is instrumental in better understanding interconnections across molecular layers and in fully utilizing the multi-omic resources available to make biological discoveries. We present here PaintOmics 3, a web-based resource for the integrated visualization of multiple omic data types onto KEGG pathway diagrams. PaintOmics 3 combines server-end capabilities for data analysis with the potential of modern web resources for data visualization, providing researchers with a powerful framework for interactive exploration of their multi-omics information...
July 2, 2018: Nucleic Acids Research
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