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https://www.readbyqxmd.com/read/28074841/the-mito-damp-cardiolipin-blocks-il-10-production-causing-persistent-inflammation-during-bacterial-pneumonia
#1
Krishnendu Chakraborty, Mahesh Raundhal, Bill B Chen, Christina Morse, Yulia Y Tyurina, Anupriya Khare, Timothy B Oriss, Rachael Huff, Janet S Lee, Claudette M St Croix, Simon Watkins, Rama K Mallampalli, Valerian E Kagan, Anuradha Ray, Prabir Ray
Bacterial pneumonia is a significant healthcare burden worldwide. Failure to resolve inflammation after infection precipitates lung injury and an increase in morbidity and mortality. Gram-negative bacteria are common in pneumonia and increased levels of the mito-damage-associated molecular pattern (DAMP) cardiolipin can be detected in the lungs. Here we show that mice infected with Klebsiella pneumoniae develop lung injury with accumulation of cardiolipin. Cardiolipin inhibits resolution of inflammation by suppressing production of anti-inflammatory IL-10 by lung CD11b(+)Ly6G(int)Ly6C(lo)F4/80(+) cells...
January 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/24368768/down-regulated-peroxisome-proliferator-activated-receptor-%C3%AE-ppar%C3%AE-in-lung-epithelial-cells-promotes-a-ppar%C3%AE-agonist-reversible-proinflammatory-phenotype-in-chronic-obstructive-pulmonary-disease-copd
#2
Sowmya P Lakshmi, Aravind T Reddy, Yingze Zhang, Frank C Sciurba, Rama K Mallampalli, Steven R Duncan, Raju C Reddy
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory condition and a leading cause of death, with no available cure. We assessed the actions in pulmonary epithelial cells of peroxisome proliferator-activated receptor γ (PPARγ), a nuclear hormone receptor with anti-inflammatory effects, whose role in COPD is largely unknown. We found that PPARγ was down-regulated in lung tissue and epithelial cells of COPD patients, via both reduced expression and phosphorylation-mediated inhibition, whereas pro-inflammatory nuclear factor-κB (NF-κB) activity was increased...
March 7, 2014: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/24289273/gene-environment-interaction-effects-on-lung-function-a-genome-wide-association-study-within-the-framingham-heart-study
#3
Shu-Yi Liao, Xihong Lin, David C Christiani
BACKGROUND: Previous studies in occupational exposure and lung function have focused only on the main effect of occupational exposure or genetics on lung function. Some disease-susceptible genes may be missed due to their low marginal effects, despite potential involvement in the disease process through interactions with the environment. Through comprehensive genome-wide gene-environment interaction studies, we can uncover these susceptibility genes. Our objective in this study was to explore gene by occupational exposure interaction effects on lung function using both the individual SNPs approach and the genetic network approach...
2013: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/21283735/expression-based-in-silico-screening-of-candidate-therapeutic-compounds-for-lung-adenocarcinoma
#4
Guiping Wang, Yun Ye, Xiaoqin Yang, Hongying Liao, Canguo Zhao, Shuang Liang
BACKGROUND: Lung adenocarcinom (AC) is the most common form of lung cancer. Currently, the number of medical options to deal with lung cancer is very limited. In this study, we aimed to investigate potential therapeutic compounds for lung adenocarcinoma based on integrative analysis. METHODOLOGY/PRINCIPAL FINDINGS: The candidate therapeutic compounds were identified in a two-step process. First, a meta-analysis of two published microarray data was conducted to obtain a list of 343 differentially expressed genes specific to lung AC...
2011: PloS One
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