Read by QxMD icon Read


Rui Zhang, Xiaoxiang Wang, Xuesheng Zhang, Junjiang Zhang, Xiaowei Zhang, Xiao Shi, Doug Crump, Robert J Letcher, John P Giesy, Chunsheng Liu
It is hypothesized that key genes, other than ahr2, are present and associated with the development of a unique type of notochord malformation known as wavy notochord in early life stages of zebrafish following exposure to polychlorinated diphenylsulfides (PCDPSs). To investigate the potential mechanism(s), time-dependent developmental morphologies of zebrafish embryos following exposure to 2500 nM 2,4,4',5-tetra-CDPS, 2,2',4-tri-CDPS or 4,4'-di-CDPS were observed to determine the developmental time point when notochord twists began to occur (i...
October 18, 2018: Environmental Science & Technology
Jian-Xin Yan, Xuan Liao, Sheng-Hong Li, Hong-Wei Liu, Han-Yu Chang, Nan Dong, Yin-Di Wu, Wen-Li She, Guang-Hui Xie
OBJECTIVE: The objective of the present study was to investigate the application of a carbon arc lamp on wound healing in a rat cutaneous full-thickness wound model. BACKGROUND DATA: In clinical practice, wound healing has been promoted by irradiation with a carbon arc lamp. However, the corresponding mechanism has not been clearly defined. METHODS: A cutaneous full-thickness wound on the back of rats was irradiated using a carbon arc lamp at a wavelength peak range of 620-740 nm with 54 J/cm2 ...
October 18, 2018: Photomedicine and Laser Surgery
Haiwen Li, Yu Cui, Jun Wei, Chao Liu, Yuhan Chen, Chun-Ping Cui, Lei Li, Xueli Zhang, Lingqiang Zhang
The bone morphogenetic protein (BMP)-Smad signaling pathway plays a crucial role in the control of bone homeostasis by regulating osteoblast activity. It is known that the ubiquitin ligase Smad ubiquitination regulatory factor (Smurf)1 is a master negative regulator of BMP signaling, but how its stability and activity are regulated remains poorly understood. Our study showed that valosin-containing protein/p97, the mutations of which lead to rare forms of Paget's disease of bone (PDB)-like syndrome-such as inclusion body myopathy (IBM) associated with Paget's disease of bone and frontotemporal dementia (IBM-PFD)-together with its adaptor nuclear protein localization (NPL)4, specifically interact with Smurf1 and deliver the ubiquitinated Smurf1 for degradation...
October 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Anoop Singh Chauhan, Xiaoguang Liu, Ji Jing, Hyemin Lee, Raj Kumar Yadav, Jindou Liu, Yubin Zhou, Boyi Gan
AMPK is a crucial regulator of energy homeostasis that acts downstream of its upstream kinase liver kinase B1 (LKB1) and calcium/calmodulin-dependent protein kinase 2 (CaMKK2). LKB1 primarily phosphorylates AMPK after energy stress, whereas calcium-mediated activation of AMPK requires CaMKK2, although the regulatory mechanisms of calcium-mediated AMPK activation remain unclear. Using biochemical, microscopic, and genetic approaches, we demonstrate that the stromal interaction molecule (STIM)2, a calcium sensor, acts as a novel regulator of CaMKK2-AMPK signaling...
October 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Zhaojun Teng, Qian Nie, Cheng Guo, Qian Zhang, Yanling Liu, Brad J Bushman
Although adolescents around the world play video games, little is known about their longitudinal effects on adolescents from Eastern countries. This large longitudinal violent video game study has 4 strengths. First, it is the first longitudinal study conducted with Chinese adolescents. Second, it examines moral disengagement as a possible mediating variable. Because violent video games reward immoral behaviors (e.g., stealing cars, killing characters), they might lead players to believe immoral behaviors are "no big deal...
October 18, 2018: Developmental Psychology
Yi Zhang, David J Muscatello, Quanyi Wang, Peng Yang, Yang Pan, Da Huo, Zhongcheng Liu, Xiaojuan Zhao, Yaqing Tang, Chao Li, Abrar A Chughtai, C Raina MacIntyre
We analyzed surveillance data for 2 sentinel hospitals to estimate the influenza-associated severe acute respiratory infection hospitalization rate in Beijing, China. The rate was 39 and 37 per 100,000 persons during the 2014-15 and 2015-16 influenza seasons, respectively. Rates were highest for children <5 years of age.
November 2018: Emerging Infectious Diseases
Pavan K Bhatraju, Leila R Zelnick, Jerald Herting, Ronit Katz, Carmen Mikacenic, Susanna Kosamo, Eric D Morrell, Cassianne Robinson-Cohen, Carolyn S Calfee, Jason D Christie, Kathleen D Liu, Michael A Matthay, William O Hahn, Victoria Dmyterko, Natalie S J Slivinski, Jim A Russell, Keith R Walley, David C Christiani, W Conrad Liles, Jonathan Himmelfarb, Mark M Wurfel
OBJECTIVE: The aim of this study was to identify and test whether AKI sub-phenotypes have prognostic and therapeutic implications. METHODS: First, latent class analysis methodology was applied independently in two critically ill populations (Discovery: n=794 and Replication: n=425) with AKI. Second, a parsimonious classification model was developed to identify AKI sub-phenotypes. Third, the classification model was applied to patients with AKI in the Vasopressin in Septic Shock (VASST: n=271) clinical trial and differences in treatment response were determined...
October 18, 2018: American Journal of Respiratory and Critical Care Medicine
Wen-Fan Shen, Jedhan Ucat Galula, Jyung-Hurng Liu, Mei-Ying Liao, Chang-Hao Huang, Yu-Chun Wang, Han-Chung Wu, Jian-Jong Liang, Yi-Ling Lin, Matthew T Whitney, Gwong-Jen J Chang, Sheng-Ren Chen, Shang-Rung Wu, Day-Yu Chao
Dengue fever is caused by four different serotypes of dengue virus (DENV) which is the leading cause of worldwide arboviral diseases in humans. Virus-like particles (VLPs) containing flavivirus prM/E proteins have been demonstrated to be a potential vaccine candidate; however, the structure of dengue VLP is poorly understood. Herein VLP derived from DENV serotype-2 were engineered becoming highly matured (mD2VLP) and showed variable size distribution with diameter of ~31nm forming the major population under cryo-electron microscopy examination...
October 18, 2018: ELife
Zhengqing Liu, Ziyang Lu, Michel Bosman, Na Li, Terry J Frankcombe, Guohua Jia, Antonio Tricoli, Yun Liu, Yaping Du, Zongyou Yin
Durability is still one of the key obstacles for the further development of photocatalytic energy-conversion systems, especially low-dimensional ones. Encouragingly, recent studies show that nanoinsulators such as SiO2 and MgO exhibit substantially enhanced photocatalytic durability than the typical semiconductor p25 TiO2 . Extending this knowledge, MgO-Au plasmonic defect nanosystems are developed that combine the stable photoactivity from MgO surface defects with energy-focusing plasmonics from Au nanoparticles (NPs), where Au NPs are anchored onto monodispersed MgO nanotemplates...
October 17, 2018: Small
Tyler R McCaw, Mei Li, Dmytro Starenki, Sara J Cooper, Mingyong Liu, Selene Meza-Perez, Rebecca C Arend, Donald J Buchsbaum, Andres Forero, Troy D Randall
The expression of MHC class II molecules (MHCII) on tumor cells correlates with survival and responsiveness to immunotherapy. However, the mechanisms underlying these observations are poorly defined. Using a murine breast tumor line, we showed that MHCII-expressing tumors grew more slowly than controls and recruited more functional CD4+ and CD8+ T cells. In addition, MHCII-expressing tumors contained more TCR clonotypes expanded to a larger degree than control tumors. Functional CD8+ T cells in tumors depended on CD4+ T cells...
October 17, 2018: Cancer Immunology, Immunotherapy: CII
Chuancheng Jia, Marjan Famili, Marco Carlotti, Yuan Liu, Peiqi Wang, Iain M Grace, Ziying Feng, Yiliu Wang, Zipeng Zhao, Mengning Ding, Xiang Xu, Chen Wang, Sung-Joon Lee, Yu Huang, Ryan C Chiechi, Colin J Lambert, Xiangfeng Duan
Molecular transistors operating in the quantum tunneling regime represent potential electronic building blocks for future integrated circuits. However, due to their complex fabrication processes and poor stability, traditional molecular transistors can only operate stably at cryogenic temperatures. Here, through a combined experimental and theoretical investigation, we demonstrate a new design of vertical molecular tunneling transistors, with stable switching operations up to room temperature, formed from cross-plane graphene/self-assembled monolayer (SAM)/gold heterostructures...
October 2018: Science Advances
Jeffrey W Tyner, Cristina E Tognon, Daniel Bottomly, Beth Wilmot, Stephen E Kurtz, Samantha L Savage, Nicola Long, Anna Reister Schultz, Elie Traer, Melissa Abel, Anupriya Agarwal, Aurora Blucher, Uma Borate, Jade Bryant, Russell Burke, Amy Carlos, Richie Carpenter, Joseph Carroll, Bill H Chang, Cody Coblentz, Amanda d'Almeida, Rachel Cook, Alexey Danilov, Kim-Hien T Dao, Michie Degnin, Deirdre Devine, James Dibb, David K Edwards, Christopher A Eide, Isabel English, Jason Glover, Rachel Henson, Hibery Ho, Abdusebur Jemal, Kara Johnson, Ryan Johnson, Brian Junio, Andy Kaempf, Jessica Leonard, Chenwei Lin, Selina Qiuying Liu, Pierrette Lo, Marc M Loriaux, Samuel Luty, Tara Macey, Jason MacManiman, Jacqueline Martinez, Motomi Mori, Dylan Nelson, Ceilidh Nichols, Jill Peters, Justin Ramsdill, Angela Rofelty, Robert Schuff, Robert Searles, Erik Segerdell, Rebecca L Smith, Stephen E Spurgeon, Tyler Sweeney, Aashis Thapa, Corinne Visser, Jake Wagner, Kevin Watanabe-Smith, Kristen Werth, Joelle Wolf, Libbey White, Amy Yates, Haijiao Zhang, Christopher R Cogle, Robert H Collins, Denise C Connolly, Michael W Deininger, Leylah Drusbosky, Christopher S Hourigan, Craig T Jordan, Patricia Kropf, Tara L Lin, Micaela E Martinez, Bruno C Medeiros, Rachel R Pallapati, Daniel A Pollyea, Ronan T Swords, Justin M Watts, Scott J Weir, David L Wiest, Ryan M Winters, Shannon K McWeeney, Brian J Druker
The implementation of targeted therapies for acute myeloid leukaemia (AML) has been challenging because of the complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Here we report initial findings from the Beat AML programme on a cohort of 672 tumour specimens collected from 562 patients. We assessed these specimens using whole-exome sequencing, RNA sequencing and analyses of ex vivo drug sensitivity. Our data reveal mutational events that have not previously been detected in AML...
October 17, 2018: Nature
Binsheng Luo, Yujing Liu, Bo Liu, Sizhao Liu, Beixi Zhang, Linghan Zhang, Chunrui Lin, Yan Liu, Edward J Kennelly, Zhiyong Guo, Chunlin Long
BACKGROUND: The traditional medicinal markets held during the Dragon Boat Festival are common and important in China's countryside. In Jianghua, a Yao autonomous county in Hunan Province in China, the medicinal market also plays an important role for the application, conservation, and communication of traditional Yao medicinal knowledge. METHODS: During the Dragon Boat Festival in 2016 and 2017, ethnobotanical surveys and inventories were conducted in the medicinal market of Jianghua County, and voucher plant specimens were collected, identified, and deposited in a herbarium...
October 17, 2018: Journal of Ethnobiology and Ethnomedicine
Antonia De Maio, Hari Krishna Yalamanchili, Carolyn J Adamski, Vincenzo A Gennarino, Zhandong Liu, Jun Qin, Sung Y Jung, Ronald Richman, Harry Orr, Huda Y Zoghbi
RNA splicing entails the coordinated interaction of more than 150 proteins in the spliceosome, one of the most complex of the cell's molecular machines. We previously discovered that the RNA-binding motif protein 17 (RBM17), a component of the spliceosome, is essential for survival and cell maintenance. Here, we find that it interacts with the spliceosomal factors U2SURP and CHERP and that they reciprocally regulate each other's stability, both in mouse and in human cells. Individual knockdown of each of the three proteins induces overlapping changes in splicing and gene expression of transcripts enriched for RNA-processing factors...
October 16, 2018: Cell Reports
Scott A Hinger, Diana J Cha, Jeffrey L Franklin, James N Higginbotham, Yongchao Dou, Jie Ping, Lihua Shu, Nripesh Prasad, Shawn Levy, Bing Zhang, Qi Liu, Alissa M Weaver, Robert J Coffey, James G Patton
The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. We previously showed that mutant KRAS colorectal cancer (CRC) cells release extracellular vesicles (EVs) containing distinct proteomes, microRNAs (miRNAs), and circular RNAs. Here, we comprehensively identify diverse classes of CRC extracellular long RNAs secreted in EVs and demonstrate differential export of specific RNAs. Distinct noncoding RNAs, including antisense transcripts and transcripts derived from pseudogenes, are enriched in EVs compared to cellular profiles...
October 16, 2018: Cell Reports
Mehmet A Bilen, Dylan J Martini, Yuan Liu, Colleen Lewis, Hannah H Collins, Julie M Shabto, Mehmet Akce, Haydn T Kissick, Bradley C Carthon, Walid L Shaib, Olatunji B Alese, Rathi N Pillai, Conor E Steuer, Christina S Wu, David H Lawson, Ragini R Kudchadkar, Bassel F El-Rayes, Viraj A Master, Suresh S Ramalingam, Taofeek K Owonikoko, R Donald Harvey
BACKGROUND: Optimal prognostic and predictive biomarkers for patients with advanced-stage cancer patients who received immunotherapy (IO) are lacking. Inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), the monocyte-to-lymphocyte ratio (MLR), and the platelet-to-lymphocyte ratio (PLR), are readily available. The authors investigated the association between these markers and clinical outcomes of patients with advanced-stage cancer who received IO. METHODS: A retrospective review was conducted of 90 patients with advanced cancer who received treatment on phase 1 clinical trials of IO-based treatment regimens...
October 17, 2018: Cancer
David A Mahvi, Rong Liu, Mark W Grinstaff, Yolonda L Colson, Chandrajit P Raut
Locoregional recurrence negatively impacts both long-term survival and quality of life for several malignancies. For appropriate-risk patients with an isolated, resectable, local recurrence, surgery represents the only potentially curative therapy. However, oncologic outcomes remain inferior for patients with locally recurrent disease even after macroscopically complete resection. Unfortunately, these operations are often extensive, with significant perioperative morbidity and mortality. This review highlights selected malignancies (mesothelioma, sarcoma, lung cancer, breast cancer, rectal cancer, and peritoneal surface malignancies) in which surgical resection is a key treatment modality and local recurrence plays a significant role in overall oncologic outcome with regard to survival and quality of life...
October 17, 2018: CA: a Cancer Journal for Clinicians
Zhenmi Liu, Jo C Dumville, Robert J Hinchliffe, Nicky Cullum, Fran Game, Nikki Stubbs, Michael Sweeting, Frank Peinemann
BACKGROUND: Foot wounds in people with diabetes mellitus (DM) are a common and serious global health issue. People with DM are prone to developing foot ulcers and, if these do not heal, they may also undergo foot amputation surgery resulting in postoperative wounds. Negative pressure wound therapy (NPWT) is a technology that is currently used widely in wound care. NPWT involves the application of a wound dressing attached to a vacuum suction machine. A carefully controlled negative pressure (or vacuum) sucks wound and tissue fluid away from the treated area into a canister...
October 17, 2018: Cochrane Database of Systematic Reviews
Li Liu, Paragi Patel, Jena J Steinle
OBJECTIVE AND DESIGN: Inflammation is a key component of a number of diseases, including diabetic retinopathy. We investigated the cellular pathway by which protein kinase A (PKA) inhibited high mobility group box 1 (HMGB1). METHODS: Primary human retinal endothelial cells (REC) were grown in normal glucose (5 mM) or high glucose (25 mM). Cells in high glucose were treated with exchange protein for cAMP 1 (Epac1) and IGFBP-3 siRNA. Additional cells in high glucose were treated with forskolin, a PKA agonist, and Epac1 siRNA...
October 17, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Xiao-Jing Yu, Yu-Wang Miao, Hong-Bao Li, Qing Su, Kai-Li Liu, Li-Yan Fu, Yi-Kang Hou, Xiao-Lian Shi, Ying Li, Jian-Jun Mu, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Philip J Ebenezer, Joseph Francis, Yu-Ming Kang
Angiotensin (Ang)-(1-7) is an important biologically-active peptide of the renin-angiotensin system. This study was designed to determine whether inhibition of Ang-(1-7) in the hypothalamic paraventricular nucleus (PVN) attenuates sympathetic activity and elevates blood pressure by modulating pro-inflammatory cytokines (PICs) and oxidative stress in the PVN in salt-induced hypertension. Rats were fed either a high-salt (8% NaCl) or a normal salt diet (0.3% NaCl) for 10 weeks, followed by bilateral microinjections of the Ang-(1-7) antagonist A-779 or vehicle into the PVN...
October 16, 2018: Neuroscience Bulletin
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"