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JOURNAL ARTICLE
Soo Heon Kwak, Ryan B Hernandez-Cancela, Daniel A DiCorpo, David E Condon, Jordi Merino, Peitao Wu, Jennifer A Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep M Mercader, Sujin Lee, Jeffrey Haessler, Ha My T Vy, Zhaotong Lin, Nicole D Armstrong, Shaopeng Gu, Noah L Tsao, Leslie A Lange, Ningyuan Wang, Kerri L Wiggins, Stella Trompet, Simin Liu, Ruth J F Loos, Renae Judy, Philip H Schroeder, Natalie R Hasbani, Maxime M Bos, Alanna C Morrison, Rebecca D Jackson, Alexander P Reiner, JoAnn E Manson, Ninad S Chaudhary, Lynn K Carmichael, Yii-Der Ida Chen, Kent D Taylor, Mohsen Ghanbari, Joyce van Meurs, Achilleas N Pitsillides, Bruce M Psaty, Raymond Noordam, Ron Do, Kyong Soo Park, J Wouter Jukema, Maryam Kavousi, Adolfo Correa, Stephen S Rich, Scott M Damrauer, Catherine Hajek, Nam H Cho, Marguerite R Irvin, James S Pankow, Girish N Nadkarni, Robert Sladek, Mark O Goodarzi, Jose C Florez, Daniel I Chasman, Susan R Heckbert, Charles Kooperberg, Josée Dupuis, Rajeev Malhotra, Paul S de Vries, Ching-Ti Liu, Jerome I Rotter, James B Meigs
OBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18...
April 23, 2024: Diabetes Care
#2
JOURNAL ARTICLE
Ashley M Fuller, Hawley C Pruitt, Ying Liu, Valerie M Irizarry-Negron, Hehai Pan, Hoogeun Song, Ann DeVine, Rohan S Katti, Samir Devalaraja, Gabrielle E Ciotti, Michael V Gonzalez, Erik F Williams, Ileana Murazzi, Dimitris Ntekoumes, Nicolas Skuli, Hakon Hakonarson, Daniel J Zabransky, Jose G Trevino, Ashani Weeraratna, Kristy Weber, Malay Haldar, Joseph A Fraietta, Sharon Gerecht, T S Karin Eisinger-Mathason
CD8+ T cell dysfunction impedes anti-tumor immunity in solid cancers but the underlying mechanisms are diverse and poorly understood. Extracellular matrix (ECM) composition has been linked to impaired T cell migration and enhanced tumor progression; however, impacts of individual ECM molecules on T cell function in the tumor microenvironment (TME) are only beginning to be elucidated. Upstream regulators of aberrant ECM deposition and organization in solid tumors are equally ill-defined. Therefore, we investigated how ECM composition modulates CD8+ T cell function in undifferentiated pleomorphic sarcoma (UPS), an immunologically active desmoplastic tumor...
April 23, 2024: Journal of Clinical Investigation
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JOURNAL ARTICLE
Liming Zhang, Yaxuan Liu, Ruiming Chu, Yan Zhao, Bing Liu, Chunguo Fan, Peng Song
PURPOSE: To determine the caries status in children's deciduous teeth and examine the influence of family oral health behaviours on the caries status. MATERIALS AND METHODS: This cross-sectional study included 329 children aged 3-6 years in rural Heishanzui Township, Hebei Province, China, and used a completely random sampling method. These children underwent physical and oral health examinations. The questionnaires were given to the parents and caregivers of the examined children...
April 23, 2024: Oral Health & Preventive Dentistry
#4
JOURNAL ARTICLE
Monica Yun Liu, Belinda Chen, Mehdi Borji, Carolina Garcia de Alba Rivas, Antonella F M Dost, Aaron L Moye, Nusrath Movval Abdulla, Margherita Paschini, Stuart D Rollins, Ruobing Wang, Lynn M Schnapp, Hassan A Khalil, Catherine J Wu, Nirmal S Sharma, Carla F Kim
No abstract text is available yet for this article.
April 23, 2024: American Journal of Respiratory and Critical Care Medicine
#5
JOURNAL ARTICLE
Eugen F Mesaros, Benjamin J Dugan, Min Gao, Muhammad Sheraz, Kayleigh McGovern-Gooch, Fran Xu, Kristi Yi Fan, Duyan Nguyen, Steven G Kultgen, Aaron Lindstrom, Kim Stever, Breanna Tercero, Randall J Binder, Fei Liu, Holly M Micolochick Steuer, Nagraj Mani, Troy O Harasym, Emily P Thi, Andrea Cuconati, Bruce D Dorsey, Andrew G Cole, Angela M Lam, Michael J Sofia
The recent COVID-19 pandemic underscored the limitations of currently available direct-acting antiviral treatments against acute respiratory RNA-viral infections and stimulated major research initiatives targeting anticoronavirus agents. Two novel nsp5 protease (MPro) inhibitors have been approved, nirmatrelvir and ensitrelvir, along with two existing nucleos(t)ide analogues repurposed as nsp12 polymerase inhibitors, remdesivir and molnupiravir, but a need still exists for therapies with improved potency and systemic exposure with oral dosing, better metabolic stability, and reduced resistance and toxicity risks...
April 23, 2024: ACS Infectious Diseases
#6
JOURNAL ARTICLE
Siyu Chai, Shuhua Li, Ruxin Zhu, Li Luo, Kaiqin Chen, Yinlei Lei, Weihong Wan, Xijie Hu, Shiquan Liu, Pengyu Chen
UNLABELLED: Short tandem repeats (STRs) are the most common genetic markers in forensic and human population genetics due to their high polymorphism, rapid detection, and reliable genotyping. To adapt the rapid growth of forensic DNA database and solve problems in disputed cases, a panel of 23 autosomal STR loci with high discriminating ability was constructed recently. The Tai-Kadai-speaking Gelao is the most ancient indigenous minority in Guizhou province, however, the forensic efficiency and population genetic structure remain poorly explored...
June 2024: Forensic Sciences Research
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JOURNAL ARTICLE
John Rahilly, Ben Amies-Cull, Michael Chang, Steven Cummins, Daniel Derbyshire, Suzan Hassan, Yuru Huang, Matthew Keeble, Bochu Liu, Antonieta Medina-Lara, Oliver Mytton, Nina Rogers, Bea Savory, Annie Schiff, Stephen J Sharp, Richard Smith, Claire Thompson, Martin White, Jean Adams, Thomas Burgoine
By the end of 2017, 35 local authorities (LAs) across England had adopted takeaway management zones (or "exclusion zones") around schools as a means to curb proliferation of new takeaways. In this nationwide, natural experimental study, we evaluated the impact of management zones on takeaway retail, including unintended displacement of takeaways to areas immediately beyond management zones, and impacts on chain fast-food outlets. We used uncontrolled interrupted time series analyses to estimate changes from up to six years pre- and post-adoption of takeaway management zones around schools...
June 2024: SSM—Population Health
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JOURNAL ARTICLE
Yancheng Song, Wencong Guo, Junke Wang, Shuguang Liu, Zhaopeng Li, Yu Li
BACKGROUND: Recent research showed that probiotics treatment may reduce insulin resistance, regulate lipid metabolism, raise liver enzyme levels, and ameliorate inflammation in individuals with metabolic associated fatty liver disease (MAFLD). However, the possible effects of probiotic use on the progression of hepatic steatosis (HS) have not been identified. The purpose of this study was to investigate this in a large population database. METHODS: The cross-sectional research was conducted among adults with complete data on probiotic yogurt consumption and HS in the 2011-2016 National Health and Nutrition Examination Survey (NHANES)...
2024: Frontiers in Nutrition
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JOURNAL ARTICLE
Che-Cheng Chang, Tzu-Chi Liu, Chi-Jie Lu, Hou-Chang Chiu, Wei-Ning Lin
Diagnostic markers for myasthenia gravis (MG) are limited; thus, innovative approaches are required for supportive diagnosis and personalized care. Gut microbes are associated with MG pathogenesis; however, few studies have adopted machine learning (ML) to identify the associations among MG, gut microbiota, and metabolites. In this study, we developed an explainable ML model to predict biomarkers for MG diagnosis. We enrolled 19 MG patients and 10 non-MG individuals. Stool samples were collected and microbiome assessment was performed using 16S rRNA sequencing...
December 2024: Computational and Structural Biotechnology Journal
#10
JOURNAL ARTICLE
Stefan Paporakis, Kenny T-C Liu, Stuart J Brown, Jason B Harper, Andrew V Martin, Tamar L Greaves
While protic ionic liquids (ILs) have found great success as solvents for a broad range of applications, little is known about their degradation when exposed to temperatures above ambient for extended periods of time. Here, we report the thermal stability of six protic ILs, namely, ethylammonium nitrate, ethylammonium formate, ethylammonium acetate, ethanolammonium nitrate, ethanolammonium formate, and ethanolammonium acetate. The effect of heating each ionic liquid to 60 °C for 1 h or 1 week (sealed or open to the atmosphere) was evaluated by considering the changes to water content, pH, mass, thermal phase transitions, and molecular structure after each treatment...
April 22, 2024: Journal of Physical Chemistry. B
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JOURNAL ARTICLE
Hao Wang, Andrii Ishchenko, Jason Skudlarek, Pamela Shen, Liudmila Dzhekieva, Ronald E Painter, Yun-Ting Chen, Marina Bukhtiyarova, Andrew Leithead, Rodger Tracy, Kerim Babaoglu, Carolyn Bahnck-Teets, Alexei Buevich, Tamara D Cabalu, Marc Labroli, Henry Lange, Ying Lei, Wei Li, Jian Liu, Paul A Mann, Tao Meng, Helen J Mitchell, James Mulhearn, Giovanna Scapin, Deyou Sha, Anthony W Shaw, Qian Si, Ling Tong, Chengwei Wu, Zhe Wu, Jing Chen Xiao, Min Xu, Li-Kang Zhang, David McKenney, Randy R Miller, Todd A Black, Andrew Cooke, Carl J Balibar, Daniel J Klein, Izzat Raheem, Scott S Walker
Carbapenem-resistant Acinetobacter baumannii infections have limited treatment options. Synthesis, transport and placement of lipopolysaccharide or lipooligosaccharide (LOS) in the outer membrane of Gram-negative bacteria are important for bacterial virulence and survival. Here we describe the cerastecins, inhibitors of the A. baumannii transporter MsbA, an LOS flippase. These molecules are potent and bactericidal against A. baumannii, including clinical carbapenem-resistant Acinetobacter baumannii isolates...
April 22, 2024: Nature Microbiology
#12
JOURNAL ARTICLE
Rameez Ahmad Mir, Amir Hoseini Ahmadian Hoseini, Evan J Hansen, Li Tao, Yue Zhang, Jian Liu
Hybrid supercapacitors (HSCs) bridge the unique advantages of batteries and capacitors and are considered promising energy storage devices for hybrid vehicles and other electronic gadgets. Lithium-ion capacitors (LICs) have attained particular interest due to their higher energy and power density than traditional supercapacitor devices. The limited voltage window and the deterioration of anode materials upsurged the demand for efficient and stable electrode materials. Two-dimensional (2D) molybdenum sulfide (MoS2) is a promising candidate for developing efficient and durable LICs due to its wide lithiation potential and unique layer structure, enhancing charge storage efficiency...
April 22, 2024: Chemistry: a European Journal
#13
JOURNAL ARTICLE
Jie Ma, Xiao-Yan Chu, Huo-Sheng Liu, Ji-Ya Sun, Hong-Sheng Zhan, Jian-de Xu, Tian-Feng He, Jin-Lei Ding, Li-Yan Zhou, Xi-Dong Duan, Qian Wang, Xing-Hong Bing, Shan-Ping Tao
OBJECTIVES: To compare the clinical effect of combined therapy of acupotomy and electroacupuncture (EA) with the simple application of EA on knee osteoarthritis (KOA), and their influence on knee function. METHODS: Sixty-eight KOA patients were randomly divided into 2 groups, an acupotomy group and an EA group. In the acupotomy group, the combined therapy of acupotomy and EA was adopted. In the EA group, EA was simply used, delivered once every two days, 3 treatments a week；and the duration of treatment was 4 weeks...
April 25, 2024: Zhen Ci Yan Jiu, Acupuncture Research
#14
JOURNAL ARTICLE
Ming-Yue Yu, Kai-Qi Su, Xin Shen, Huan-Huan Liu, Jing Gao, Jian Guo, Xiao-Dong Feng
OBJECTIVES: To observe the effect of electroacupuncture (EA) at "Baihui" (GV20) and "Shenting" (GV24) on the rats' behavior and the transforming precursor of brain-derived neurotrophic factor (proBDNF) into mature brain-derived neurotrophic factor (mBDNF) in the hippocampus of rats with learning and memory impairment induced by cerebral ischemia-reperfusion (IR), so as to explore its mechanisms underlying improvement of learning and memory ability. METHODS: SD rats were randomly divided into blank, sham operation, model, and EA groups, with 6 rats in each group...
April 25, 2024: Zhen Ci Yan Jiu, Acupuncture Research
#15
JOURNAL ARTICLE
Guang-Tong Lu, Xi-Sheng Fan, Xue-Song Wang, Guang Zuo, Yi Zhang, Ming-Jian Zhang, Miao Lin, Jin Liu, Jun Liu, Jun-Cha Zhang, Xu-Liang Shi, Yan-Fen She
OBJECTIVES: To investigate the effect of electroacupuncture (EA) on Rho/Rho-associated coiled-coil-forming kinases (ROCK) signaling pathway of uterus tissue in rats with dysmenorrhea, so as to explore the underlying mechanism of EA treating primary dysmenorrhea (PD) and uterine smooth muscle spasm, and to observe whether there is a difference in the effect of meridian acupoints in Conception Vessel (CV) and Governer Vessel (GV). METHODS: Sixty female SD rats were randomly divided into saline, model, CV, GV, and non-acupoint groups, with 12 rats in each group...
April 25, 2024: Zhen Ci Yan Jiu, Acupuncture Research
#16
JOURNAL ARTICLE
Yan-Wei Li, Bao-Min Dou, Shen-Jun Wang, Zhong-Xi Lü, Wei Li, Zhi-Fang Xu, Yang-Yang Liu, Yuan Xu, Yu-Xin Fang, Yong-Ming Guo, Yi Guo
OBJECTIVES: To observe whether acupuncture up-regulates chemokine CXC ligand 1 (CXCL1) in the brain to play an analgesic role through CXCL1/chemokine CXC receptor 2 (CXCR2) signaling in adjuvant induced arthritis (AIA) rats, so as to reveal its neuro-immunological mechanism underlying improvement of AIA. METHODS: BALB/c mice with relatively stable thermal pain reaction were subjected to planta injection of complete Freund adjuvant (CFA) for establishing AIA model, followed by dividing the AIA mice into simple AF750 (fluorochrome) and AF750+CXCL1 groups ( n =2 in each group)...
April 25, 2024: Zhen Ci Yan Jiu, Acupuncture Research
#17
JOURNAL ARTICLE
Christopher J Humphreys, Ran R Liu, Taryn M Simms
No abstract text is available yet for this article.
April 21, 2024: Canadian Medical Association Journal: CMAJ
#18
JOURNAL ARTICLE
Siling Liu, Linjie Su, Jie Li, Yuexin Zhang, Xiaopei Hu, Pengcheng Wang, Peiqing Liu, Jiantao Ye
Pathological cardiac hypertrophy often precedes heart failure due to various stimuli, yet effective clinical interventions remain limited. Recently, microRNAs (miRNAs) have been identified as critical regulators of cardiovascular development. In this study, we investigated the role of miR-146b-5p and its underlying mechanisms of action in cardiac hypertrophy. Isoprenaline (ISO) treatment induced significant hypertrophy and markedly enhanced the expression of miR-146b-5p in cultured neonatal rat cardiomyocytes and hearts of C57BL/6 mice...
April 20, 2024: Molecular and Cellular Endocrinology
#19
JOURNAL ARTICLE
Wenzhao Wang, Chang Liu, Dong He, Guidong Shi, Ping Song, Boqing Zhang, Tian Li, Jianlu Wei, Yunpeng Jiang, Liang Ma
Spinal cord injury (SCI) is a complex problem in modern medicine. Fibroblast activation and fibroscarring after SCI impede nerve recovery. Non-coding RNA plays an important role in the progression of many diseases, but the study of its role in the progression of spinal fibrosis is still emerging. Here, we investigated the function of circular RNAs, specifically antisense to the cerebellar degeneration-related protein 1 (CDR1as), in spinal fibrosis and characterized its molecular mechanism and pathophysiology...
April 20, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
#20
REVIEW
Ruihua Liu, Yawei Zhao, Shang Su, Augustine Kwabil, Prisca Chinonso Njoku, Haiquan Yu, Xiaohong Li
Tumor cells disseminate in various distant organs at early stages of cancer progression. These disseminated tumor cells (DTCs) can stay dormant/quiescent without causing patient symptoms for years or decades. These dormant tumor cells survive despite curative treatments by entering growth arrest, escaping immune surveillance, and/or developing drug resistance. However, these dormant cells can reactivate to proliferate, causing metastatic progression and/or relapse, posing a threat to patients' survival. It's unclear how cancer cells maintain dormancy and what triggers their reactivation...
April 20, 2024: Cancer Letters
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