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Xing Wang, Hui Liu, Chao Shan, Weiming Zhang, Bingcai Pan
The efficient removal of Se(VI) from sulfate-rich water is challenging as most reported processes last for hours to days. In this study, a combined sulfite/UV/Fe(III) coagulation process was proposed for efficient Se(VI) removal from sulfate-rich water within a short time (∼1 h). In the presence of sulfate (1000 mg L-1 ), over 99% of Se(VI) (initially at 10 mg L-1 ) could be reduced by sulfite (5.0 mM) with a UV dose of 16 J cm-2 (within 20 min) into Se(IV) as the sole observed product. An alkaline pH (>9) was required for the reduction process, which was naturally obtained with the addition of sulfite...
August 4, 2018: Chemosphere
Sijie Lin, Kuancan Liu, Yongchun Zhang, Ming Jiang, Rong Lu, Christopher J Folts, Xia Gao, Mark D Noble, Tingting Zhao, Zhongren Zhou, Xiaopeng Lan, Jianwen Que
Drug repurposing with a better understanding of the underlying mechanism has provided new avenues to find treatment for malignancies. Esophageal adenocarcinoma (EAC) is a rapidly increasing cancer with a dismal 5-year survival rate of <15%. Lack of efficient treatment options contributes to the high mortality rate of EAC. To find new therapy against EAC we performed unbiased drug screening of an FDA-approved drug library and identified that the cardiac glycosides including Ouabain, Digoxin and Digitoxin efficiently inhibit the proliferation of EAC cell lines (OE33 and OE19) both in vitro and in vivo...
August 10, 2018: Cellular Signalling
Gina M Magnotti, Zihan Wang, Wei Liu, Raghu Sivaramakrishnan, Sibendu Som, Michael J Davis
Analysis of large-scale, realistic models incorporating detailed chemistry can be challenging because each simulation is computationally expensive, and a complete analysis may require many simulations. This paper addresses one such problem of this type, chemical-reaction selection in engine simulations. In this computationally challenging case, it is demonstrated how the important concept of sparsity can facilitate chemical reaction selection, which is the process of finding the most important chemical reactions for modeling a chemical process...
August 13, 2018: Journal of Physical Chemistry. A
Sarwish Rafiq, Oladapo O Yeku, Hollie J Jackson, Terence J Purdon, Dayenne G van Leeuwen, Dylan J Drakes, Mei Song, Matthew M Miele, Zhuoning Li, Pei Wang, Su Yan, Jingyi Xiang, Xiaojing Ma, Venkatraman E Seshan, Ronald C Hendrickson, Cheng Liu, Renier J Brentjens
The efficacy of chimeric antigen receptor (CAR) T cell therapy against poorly responding tumors can be enhanced by administering the cells in combination with immune checkpoint blockade inhibitors. Alternatively, the CAR construct has been engineered to coexpress factors that boost CAR-T cell function in the tumor microenvironment. We modified CAR-T cells to secrete PD-1-blocking single-chain variable fragments (scFv). These scFv-secreting CAR-T cells acted in both a paracrine and autocrine manner to improve the anti-tumor activity of CAR-T cells and bystander tumor-specific T cells in clinically relevant syngeneic and xenogeneic mouse models of PD-L1+ hematologic and solid tumors...
August 13, 2018: Nature Biotechnology
Hao Wu, H N Ashiqur Rahman, Yunzhou Dong, Xiaolei Liu, Yang Lee, Aiyun Wen, Kim Ht To, Li Xiao, Amy E Birsner, Lauren Bazinet, Scott Wong, Kai Song, Megan L Brophy, M Riaj Mahamud, Baojun Chang, Xiaofeng Cai, Satish Pasula, Sukyoung Kwak, Wenxia Yang, Joyce Bischoff, Jian Xu, Diane R Bielenberg, J Brandon Dixon, Robert J D'Amato, R Sathish Srinivasan, Hong Chen
Impaired lymphangiogenesis is a complication of chronic complex diseases, including diabetes. VEGF-C/VEGFR3 signaling promotes lymphangiogenesis, but how this pathway is affected in diabetes remains poorly understood. We previously demonstrated that loss of epsins 1 and 2 in lymphatic endothelial cells (LECs) prevented VEGF-C-induced VEGFR3 from endocytosis and degradation. Here, we report that diabetes attenuated VEGF-C-induced lymphangiogenesis in corneal micropocket and Matrigel plug assays in WT mice but not in mice with inducible lymphatic-specific deficiency of epsins 1 and 2 (LEC-iDKO)...
August 13, 2018: Journal of Clinical Investigation
Olivia J Kelada, Roy H Decker, Sameer K Nath, Kimberly L Johung, Ming-Qiang Zheng, Yiyun Huang, Jean-Dominique Gallezot, Chi Liu, Richard E Carson, Uwe Oelfke, David J Carlson
PURPOSE: Tumor hypoxia correlates with treatment failure in patients undergoing conventional radiation therapy. However, no published studies have investigated tumor hypoxia in patients undergoing stereotactic body radiation therapy (SBRT). We aimed to noninvasively quantify the tumor hypoxic volume (HV) in non-small cell lung cancer (NSCLC) tumors to elucidate the potential role of tumor vascular response and reoxygenation at high single doses. METHODS AND MATERIALS: Six SBRT-eligible patients with NSCLC tumors >1 cm were prospectively enrolled in an institutional review board-approved study...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
D Hagins, C Orkin, E S Daar, A Mills, C Brinson, E DeJesus, F A Post, J Morales-Ramirez, M Thompson, O Osiyemi, B Rashbaum, H-J Stellbrink, C Martorell, H Liu, Y-P Liu, D Porter, S E Collins, D SenGupta, M Das
OBJECTIVES: The single-tablet regimen rilpivirine, emtricitabine and tenofovir alafenamide (RPV/FTC/TAF) for treatment of HIV-1-infected adults was approved based on bioequivalence. We assessed the clinical efficacy, safety and tolerability of switching to RPV/FTC/TAF from either RPV/FTC/tenofovir disoproxil fumarate (TDF) or efavirenz (EFV)/FTC/TDF. METHODS: We conducted two distinct randomized, double-blind, active-controlled, noninferiority trials in participants taking RPV/FTC/TDF (Study 1216) and EFV/FTC/TDF (Study 1160)...
August 12, 2018: HIV Medicine
Manuel Montero-Odasso, Quincy J Almeida, Louis Bherer, Amer M Burhan, Richard Camicioli, Julien Doyon, Sarah Fraser, Susan Muir-Hunter, Karen Z H Li, Teresa Liu-Ambrose, William McIlroy, Laura Middleton, José A Morais, Ryota Sakurai, Mark Speechley, Akshya Vasudev, Olivier Beauchet, Jeffrey M Hausdorff, Caterina Rosano, Stephanie Studenski, Joe Verghese
Background: A new paradigm is emerging in which mobility and cognitive impairments, previously studied, diagnosed, and managed separately in older adults, are in fact regulated by shared brain resources. Deterioration in these shared brain mechanisms by normal aging and neurodegeneration increases the risk of developing dementia, falls, and fractures. This new paradigm requires an integrated approach to measuring both domains. We aim to identify a complementary battery of existing tests of mobility and cognition in community-dwelling older adults that enable assessment of motor-cognitive interactions...
June 21, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
T M Hsu, E E Noble, C M Liu, A M Cortella, V R Konanur, A N Suarez, D J Reiner, J D Hahn, M R Hayes, S E Kanoski
No abstract text is available yet for this article.
August 13, 2018: Molecular Psychiatry
Gaofei Hu, Huaizhi Liu, Yan Zhu, Marta Hernandez, Tatiana Koutchma, Suqin Shao
Furan, which has been identified as a carcinogenic risk for humans, can be induced in different foods by UV-C light. In this study, we hypothesized that furan was produced by a UV light-induced free radical mechanism and antioxidants could suppress its formation. Our results demonstrated that, by adding antioxidants, such as butylated hydroxyl toluene, ascorbic acid or gallic acid, to simulated juice or apple cider during UV-C treatment, amounts of furan were significantly reduced. For example, the concentration of furan produced in apple cider by UV-C at 9...
December 15, 2018: Food Chemistry
Changfeng Li, Ying Zhang, Xing Cheng, Hua Yuan, Shan Zhu, Jiao Liu, Qirong Wen, Yangchun Xie, Jinbao Liu, Guido Kroemer, Daniel J Klionsky, Michael T Lotze, Herbert J Zeh, Rui Kang, Daolin Tang
Pancreatic cancer is an aggressive malignancy with changes in the tumor microenvironment. Here, we demonstrate that PINK1 and PARK2 suppressed pancreatic tumorigenesis through control of mitochondrial iron-dependent immunometabolism. Using mouse models of spontaneous pancreatic cancer, we show that depletion of Pink1 and Park2 accelerates mutant Kras-driven pancreatic tumorigenesis. PINK1-PARK2 pathway-mediated degradation of SLC25A37 and SLC25A28 increases mitochondrial iron accumulation, which leads to the HIF1A-dependent Warburg effect and AIM2-dependent inflammasome activation in tumor cells...
August 3, 2018: Developmental Cell
Tao Yu, Yongjin J Zhou, Mingtao Huang, Quanli Liu, Rui Pereira, Florian David, Jens Nielsen
Engineering microorganisms for production of fuels and chemicals often requires major re-programming of metabolism to ensure high flux toward the product of interest. This is challenging, as millions of years of evolution have resulted in establishment of tight regulation of metabolism for optimal growth in the organism's natural habitat. Here, we show through metabolic engineering that it is possible to alter the metabolism of Saccharomyces cerevisiae from traditional ethanol fermentation to a pure lipogenesis metabolism, resulting in high-level production of free fatty acids...
August 2, 2018: Cell
Gilbert S Omenn, Lydie Lane, Christopher M Overall, Fernando J Corrales, Jochen M Schwenk, Young-Ki Paik, Jennifer E Van Eyk, Siqi Liu, Michael Snyder, Mark S Baker, Eric W Deutsch
The Human Proteome Project (HPP) annually reports on progress throughout the field in credibly identifying and characterizing the human protein parts list and making proteomics an integral part of multi-omics studies in medicine and the life sciences. neXtProt release 2018-01-17, the baseline for this 6th annual HPP special issue of the Journal of Proteome Research, contains 17,470 PE1 proteins, 89% of all neXtProt predicted PE1-4 proteins, up from 17,008 in release 2017-01-23 and 13,975 in release 2012-02-24...
August 12, 2018: Journal of Proteome Research
Florence J Dallo, Deepak Prabhakar, Julie Ruterbusch, Kendra Schwartz, Edward L Peterson, Bin Liu, Brian K Ahmedani
BACKGROUND: The authors compared proportions and associations of depression screening, major depression, and follow-up care of Arab Americans compared to non-Hispanic whites, non-Hispanic blacks, Asians, and Hispanics. METHODS: Administrative data was electronically abstracted from a large health system in metropolitan Detroit among 97,918 adult patients in 2014 and 2015. A valid and reliable surname list was used to identify Arab Americans. Using chi-squares, we examined the relationship between race/ethnicity and depression screening, major depression, and follow-up care...
August 12, 2018: Depression and Anxiety
Ido Somekh, Benjamin Marquardt, Yanshan Liu, Meino Rohlfs, Sebastian Hollizeck, Musa Karakukcu, Ekrem Unal, Ebru Yilmaz, Turkan Patiroglu, Murat Cansever, Shirly Frizinsky, Vicktoria Vishnvenskia-Dai, Erez Rechavi, Tali Stauber, Amos J Simon, Atar Lev, Christoph Klein, Daniel Kotlarz, Raz Somech
The original version of this article unfortunately contained mistakes in Author's name, in Table 1 and in result section.
August 11, 2018: Journal of Clinical Immunology
Idrish Ali, Juliana Silva, Shijie Liu, Sandy Shultz, Patrick Kwan, Nigel Jones, Terence J O'Brien
In the quest for developing new therapeutic targets for post-traumatic epilepsies (PTE), identifying mechanisms relevant to development and progression of disease is critical. A growing body of literature suggests involvement of neurodegenerative mechanisms in the pathophysiology of acquired epilepsies, including following traumatic brain injury (TBI). In this review, we discuss the potential of some of these mechanisms to be targets for the development of a therapy against PTE.
August 9, 2018: Neurobiology of Disease
A Eskander, M K Krzyzanowska, H D Fischer, N Liu, P C Austin, J C Irish, D J Enepekides, J Lee, E Gutierrez, E Lockhart, M Raphael, S Singh
BACKGROUND: Mucosal head and neck squamous cell cancers are often managed with multimodality treatment which can be associated with significant toxicity. The objective of this study was to assess emergency department visits and unplanned hospitalizations for these patients during and immediately after their treatment. METHODS: A cohort of patients treated for head and neck squamous cell carcinoma was developed using administrative data. Emergency department visits and hospitalizations in the 90-day post-treatment period was determined...
August 2018: Oral Oncology
Judy E Stern, Chia-Ling Liu, Howard J Cabral, Elliott G Richards, Charles C Coddington, Stacey A Missmer, Hafsatou Diop
OBJECTIVE: To quantify the effect of medical and obstetrical factors on the odds of cesarean delivery, comparing assisted reproductive technology (ART)-treated women and women with subfertility not treated with ART versus fertile women. DESIGN: Retrospective cohort. SETTING: Not applicable. PATIENT(S): Singleton deliveries to primiparous women; with the source of this data being the Massachusetts vital and hospital records linked to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System data (2004-2010)...
August 2018: Fertility and Sterility
B Liu, J Zhang, S Yang, K Ji, X Liu, B Du, Q Jia, S Qi, X Li, R Fan
It has been demonstrated that microRNAs (miRNAs) play important roles in the regulation of melanogenesis and hair color in mammals. Short tandem target mimic (STTM) has been used to effectively block small RNA functions in plants and animals. We previously showed that miR508-3p plays a functional role in regulating melanogenesis in alpaca melanocytes by directly targeting microphthalmia (MITF). To verify the effect of miR-508-3p function on melanogenesis in alpaca melanocytes, miR-508-3p was blocked using STTM technology in the present research...
August 8, 2018: Gene
Wei-Boon Khor, Venkatesh N Prajna, Prashant Garg, Jodhbir S Mehta, Lixin Xie, Zuguo Liu, Ma Dominga B Padilla, Choun-Ki Joo, Yoshitsugu Inoue, Panida Goseyarakwong, Fung-Rong Hu, Kohji Nishida, Shigeru Kinoshita, Vilavun Puangsricharern, Ai-Ling Tan, Roger Beuerman, Alvin Young, Namrata Sharma, Benjamin Haaland, Francis S Mah, Elmer Y Tu, Fiona J Stapleton, Richard L Abbott, Donald Tiang-Hwee Tan
PURPOSE: To survey the demographics, risk factors, microbiology and outcomes for infectious keratitis in Asia. DESIGN: Prospective, non-randomized clinical study METHODS: Thirteen study centers and 30 sub-centers recruited consecutive subjects over 12 - 18 months, and performed standardized data collection. A microbiological protocol standardized the processing and reporting of all isolates. Treatment of the infectious keratitis was decided by the managing ophthalmologist...
August 8, 2018: American Journal of Ophthalmology
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