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https://www.readbyqxmd.com/read/30107554/generating-genomic-platforms-to-study-candida-albicans-pathogenesis
#1
Mélanie Legrand, Sophie Bachellier-Bassi, Keunsook K Lee, Yogesh Chaudhari, Hélène Tournu, Laurence Arbogast, Hélène Boyer, Murielle Chauvel, Vitor Cabral, Corinne Maufrais, Audrey Nesseir, Irena Maslanka, Emmanuelle Permal, Tristan Rossignol, Louise A Walker, Ute Zeidler, Sadri Znaidi, Floris Schoeters, Charlotte Majgier, Renaud A Julien, Laurence Ma, Magali Tichit, Christiane Bouchier, Patrick Van Dijck, Carol A Munro, Christophe d'Enfert
No abstract text is available yet for this article.
August 10, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30019216/responses-of-patients-with-disorders-of-consciousness-to-habit-stimulation-a-quantitative-eeg-study
#2
Jingqi Li, Jiamin Shen, Shiqin Liu, Maelig Chauvel, Wenwei Yang, Jian Mei, Ling Lei, Li Wu, Jian Gao, Yong Yang
Whether habit stimulation is effective in DOC patient arousal has not been reported. In this paper, we analyzed the responses of DOC patients to habit stimulation. Nineteen DOC patients with alcohol consumption or smoking habits were recruited and 64-channel EEG signals were acquired both at the resting state and at three stimulation states. Wavelet transformation and nonlinear dynamics were used to extract the features of EEG signals and four brain lobes were selected to investigate the degree of EEG response to habit stimulation...
August 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29985998/high-frequency-stimulation-of-anterior-nucleus-of-thalamus-desynchronizes-epileptic-network-in-humans
#3
Tao Yu, Xueyuan Wang, Yongjie Li, Guojun Zhang, Gregory Worrell, Patrick Chauvel, Duanyu Ni, Liang Qiao, Chang Liu, Liping Li, Liankun Ren, Yuping Wang
Epilepsy has been classically seen as a brain disorder resulting from abnormally enhanced neuronal excitability and synchronization. Although it has been described since antiquity, there are still significant challenges achieving the therapeutic goal of seizure freedom. Deep brain stimulation of the anterior nucleus of the thalamus has emerged as a promising therapy for focal drug-resistant epilepsy; the basic mechanism of action, however, remains unclear. Here, we show that desynchronization is a potential mechanism of deep brain stimulation of the anterior nucleus of the thalamus by studying local field potentials recordings from the cortex during high-frequency stimulation (130 Hz) of the anterior nucleus of the thalamus in nine patients with drug-resistant focal epilepsy...
July 6, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29982705/generating-genomic-platforms-to-study-candida-albicans-pathogenesis
#4
Mélanie Legrand, Sophie Bachellier-Bassi, Keunsook K Lee, Yogesh Chaudhari, Hélène Tournu, Laurence Arbogast, Hélène Boyer, Murielle Chauvel, Vitor Cabral, Corinne Maufrais, Audrey Nesseir, Irena Maslanka, Emmanuelle Permal, Tristan Rossignol, Louise A Walker, Ute Zeidler, Sadri Znaidi, Floris Schoeters, Charlotte Majgier, Renaud A Julien, Laurence Ma, Magali Tichit, Christiane Bouchier, Patrick V Dijck, Carol A Munro, Christophe d'Enfert
The advent of the genomic era has made elucidating gene function on a large scale a pressing challenge. ORFeome collections, whereby almost all ORFs of a given species are cloned and can be subsequently leveraged in multiple functional genomic approaches, represent valuable resources toward this endeavor. Here we provide novel, genome-scale tools for the study of Candida albicans, a commensal yeast that is also responsible for frequent superficial and disseminated infections in humans. We have generated an ORFeome collection composed of 5099 ORFs cloned in a Gateway™ donor vector, representing 83% of the currently annotated coding sequences of C...
July 6, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29859779/could-fetal-reduction-induce-facial-cleft-report-of-a-case
#5
J Chauvel-Picard, J Massardier, A Gleizal
We describe a paramedian cleft of the lower lip that cannot be explained by embryological development in a child with only one predisposing factor, which was fetal reduction for a multiple pregnancy. To the best of our knowledge, there has been no report of a cleft that has been induced by the reduction of a multifetal pregnancy.
July 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29800755/delayed-hypersensitivity-skin-reaction-to-hydroxychloroquine-successful-short-desensitization
#6
Héloïse Barailler, Brigitte Milpied, Annick Chauvel, Pauline Claraz, Alain Taïeb, Julien Seneschal, Anne-Sophie Darrigade
No abstract text is available yet for this article.
May 22, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29679736/para-commissural-cleft-of-the-lower-lip-a-first-case-described-in-the-literature
#7
J Chauvel-Picard, A Gleizal
We described the first case of para-commissural cleft of the lower lip in a 2 year-old child. He is from a trichorionic triamniotic triplet pregnancy after ovarian stimulation. He has no history except a selective fetal reduction of the mother. We correct this cleft of the lower lip with a double plasty of Malek. The functional and aesthetic result is satisfactory. This particular cleft cannot be explained by the embryological theory. We favor two hypothesis to explain this anomaly: a vascular origin with the stapedial artery and the selective fetal reduction...
April 19, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29678807/digital-inequalities-in-the-use-of-self-tracking-diet-and-fitness-apps-interview-study-on-the-influence-of-social-economic-and-cultural-factors
#8
Faustine Régnier, Louis Chauvel
BACKGROUND: Digital devices are driving economic and social transformations, but assessing the uses, perceptions, and impact of these new technologies on diet and physical activity remains a major societal challenge. OBJECTIVE: We aimed to determine under which social, economic, and cultural conditions individuals in France were more likely to be actively invested in the use of self-tracking diet and fitness apps for better health behaviors. METHODS: Existing users of 3 diet and fitness self-tracking apps (Weight Watchers, MyFitnessPal, and sport apps) were recruited from 3 regions of France...
April 20, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29670142/quantitative-assessment-of-pb-sources-in-isotopic-mixtures-using-a-bayesian-mixing-model
#9
Jack Longman, Daniel Veres, Vasile Ersek, Donald L Phillips, Catherine Chauvel, Calin G Tamas
Lead (Pb) isotopes provide valuable insights into the origin of Pb within a sample, typically allowing for reliable fingerprinting of their source. This is useful for a variety of applications, from tracing sources of pollution-related Pb, to the origins of Pb in archaeological artefacts. However, current approaches investigate source proportions via graphical means, or simple mixing models. As such, an approach, which quantitatively assesses source proportions and fingerprints the signature of analysed Pb, especially for larger numbers of sources, would be valuable...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614460/inequality-in-old-age-cognition-across-the-world
#10
Javier Olivera, Francesco Andreoli, Anja K Leist, Louis Chauvel
Although cohort and country differences in average cognitive levels are well established, identifying the degree and determinants of inequalities in old age cognitive functioning could guide public health and policymaking efforts. We use all publicly available and representative old age surveys with comparable information to assess inequalities of cognitive functioning for six distinctive age groups in 29 countries. We document that cognitive inequalities in old age are largely determined by earlier educational inequalities as well as gender differential survival rates...
May 2018: Economics and Human Biology
https://www.readbyqxmd.com/read/29566955/-paracommissural-cleft-of-the-lower-lip-therapeutic-strategy
#11
J Chauvel-Picard, A Gleizal
We report the first case described in the literature of lateral, paracommissural cleft of the lower lip in a 2-year-old child. This anomaly caused labial incompetence requiring surgical correction. Different surgical techniques have been described for the treatment of the cleft of the upper lip. We studied each of them, analyzed the advantages and disadvantages of these techniques by inverting them and adapting them for the lower lip. We opted for the double "Z" plasty of Malek because the difference in height between the cleft side and the healthy side was important...
July 2018: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29477759/unusual-cystic-lesion-of-the-eyebrow-a-case-report-of-malignant-chondroid-syringoma
#12
J Chauvel-Picard, A Pierrefeu, O Harou, P Breton, N Sigaux
INTRODUCTION: Malignant chondroid syringomas, also known as cutaneous malignant mixed tumors, are rare neoplasms that most frequently occur on the torso or extremities of women. Here, we present an illustrated case of a facial malignant chondroid syringoma. MATERIALS AND METHODS: A 32-year-old female patient with no notable medical history presented with an approximately 1cm-wide, painless, palpably-mobile subcutaneous nodule, suggestive of a sebaceous cyst, just above the middle third of the right eyebrow...
June 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29408322/minimally-invasive-versus-standard-approach-in-lefort-1-osteotomy-in-patients-with-history-of-cleft-lip-and-palate
#13
D Séblain, J Bourlet, N Sigaux, R H Khonsari, J Chauvel Picard, A Gleizal
OBJECTIVE: Compare literature-reported efficiency and complications of the standard maxillary advancement surgery with those of a minimally invasive mucosal approach in patients with CL/P requiring Le Fort 1 osteotomy. DESIGN: Meta-analysis vs. retrospective analysis of 18 consecutive cases. SETTING: Department of maxillofacial surgery at a tertiary-level public general hospital. PARTICIPANTS: The meta-analysis encompassed Medline, Embase and Cochrane, years 1990 to 2014, inclusive...
June 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29392713/insulo-opercular-cortex-generates-oroalimentary-automatisms-in-temporal-seizures
#14
Jerome Aupy, Ika Noviawaty, Balu Krishnan, Piradee Suwankpakdee, Juan Bulacio, Jorge Gonzalez-Martinez, Imad Najm, Patrick Chauvel
OBJECTIVE: Oroalimentary automatisms (OAAs) resembling normal alimentary behavior are stereotyped complex movements that may occur during epileptic seizures. They are considered common clinical signs in temporal lobe seizures, but their anatomofunctional mechanisms are not established. We took the opportunity of presurgical intracerebral recordings to study the relations between the occurrence of OAAs and temporal/spatial features of ictal activities. METHODS: We retrospectively reviewed patients with medically intractable medial temporal lobe epilepsy who underwent stereoelectroencephalography (SEEG) at Cleveland Clinic between 2009 and 2016...
March 2018: Epilepsia
https://www.readbyqxmd.com/read/29289424/french-guidelines-on-stereoelectroencephalography-seeg-editorial-comment
#15
EDITORIAL
Patrick Chauvel, Sylvain Rheims, Aileen McGonigal, Philippe Kahane
No abstract text is available yet for this article.
February 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29158264/azole-resistance-in-a-candida-albicans-mutant-lacking-the-abc-transporter-cdr6-roa1-depends-on-tor-signaling
#16
Nitesh Kumar Khandelwal, Neeraj Chauhan, Parijat Sarkar, Brooke D Esquivel, Paola Coccetti, Ashutosh Singh, Alix T Coste, Meghna Gupta, Dominique Sanglard, Theodore C White, Murielle Chauvel, Christophe d'Enfert, Amitabha Chattopadhyay, Naseem A Gaur, Alok Kumar Mondal, Rajendra Prasad
ATP-binding cassette (ABC) transporters help export various substrates across the cell membrane and significantly contribute to drug resistance. However, a recent study reported an unusual case in which the loss of an ABC transporter in Candida albicans , orf19.4531 (previously named ROA1), increases resistance against antifungal azoles, which was attributed to an altered membrane potential in the mutant strain. To obtain further mechanistic insights into this phenomenon, here we confirmed that the plasma membrane-localized transporter (renamed CDR6/ROA1 for consistency with C...
January 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29156849/interest-of-integrins-targeting-in-glioblastoma-according-to-tumor-heterogeneity-and-cancer-stem-cell-paradigm-an-update
#17
REVIEW
Laure Malric, Sylvie Monferran, Julia Gilhodes, Sabrina Boyrie, Perrine Dahan, Nicolas Skuli, Julie Sesen, Thomas Filleron, Aline Kowalski-Chauvel, Elizabeth Cohen-Jonathan Moyal, Christine Toulas, Anthony Lemarié
Glioblastomas are malignant brain tumors with dismal prognosis despite standard treatment with surgery and radio/chemotherapy. These tumors are defined by an important cellular heterogeneity and notably contain a particular subpopulation of Glioblastoma-initiating cells, which recapitulate the heterogeneity of the original Glioblastoma. In order to classify these heterogeneous tumors, genomic profiling has also been undertaken to classify these heterogeneous tumors into several subtypes. Current research focuses on developing therapies, which could take into account this cellular and genomic heterogeneity...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29128469/the-different-patterns-of-seizure-induced-aphasia-in-temporal-lobe-epilepsies
#18
Agnès Trebuchon, Isabelle Lambert, Bernard Guisiano, Aileen McGonigal, Charline Perot, Francesca Bonini, Romain Carron, Catherine Liegeois-Chauvel, Patrick Chauvel, Fabrice Bartolomei
OBJECTIVES: Ictal language disturbances may occur in dominant hemisphere temporal lobe epilepsy (TLE), but little is known about the precise anatomoelectroclinical correlations. This study investigated the different facets of ictal aphasia in intracerebrally recorded TLE. METHODS: Video-stereoelectroencephalography (SEEG) recordings of 37 seizures in 17 right-handed patients with drug-resistant TLE were analyzed; SEEG electroclinical correlations between language disturbance and involvement of temporal lobe structures were assessed...
January 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29111409/mulan-evaluation-and-ensemble-statistical-inference-for-functional-connectivity
#19
Huifang E Wang, Karl J Friston, Christian G Bénar, Marmaduke M Woodman, Patrick Chauvel, Viktor Jirsa, Christophe Bernard
Many analysis methods exist to extract graphs of functional connectivity from neuronal networks. Confidence in the results is limited because, (i) different methods give different results, (ii) parameter setting directly influences the final result, and (iii) systematic evaluation of the results is not always performed. Here, we introduce MULAN (MULtiple method ANalysis), which assumes an ensemble based approach combining multiple analysis methods and fuzzy logic to extract graphs with the most probable structure...
February 1, 2018: NeuroImage
https://www.readbyqxmd.com/read/29039074/the-usefulness-of-stereo-electroencephalography-seeg-in-the-surgical-management-of-focal-epilepsy-associated-with-hidden-temporal-pole-encephalocele-a-case-report-and-literature-review
#20
REVIEW
João Paulo Sant Ana Santos de Souza, Jeff Mullin, Connor Wathen, Juan Bulacio, Patrick Chauvel, Lara Jehi, Jorge Gonzalez-Martinez
The authors report a case of 18-year-old woman with partial complex seizures compatible with temporal epilepsy by semiology. Due to medical refractoriness, she was referred to pre-surgical evaluation. Initially, MRI showed no significant structural abnormality and superficial scalp EEG demonstrated epileptiform activity in the frontotemporal areas. Due to the lack of clear MRI abnormalities and the potential involvement of dominant mesial temporal structures by seizure semiology and non-invasive data, extra-operative invasive evaluation using stereo-electroencephalography (SEEG) methodology was indicated...
January 2018: Neurosurgical Review
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