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https://www.readbyqxmd.com/read/28749480/caffeine-decreases-intermittent-hypoxia-in-preterm-infants-nearing-term-equivalent-age
#1
N R Dobson, L M Rhein, R A Darnall, M J Corwin, T C Heeren, E Eichenwald, L P James, B L McEntire, C E Hunt
OBJECTIVE: To determine whether intermittent hypoxia (IH) persisting after 36 weeks postmenstrual age (PMA) can be attenuated using caffeine doses sufficient to maintain caffeine concentrations >20 μg ml(-1). STUDY DESIGN: Twenty-seven infants born <32 weeks were started on caffeine citrate at 10 mg kg(-1) day(-1) when clinical caffeine was discontinued. At 36 weeks PMA, the dose was increased to 14 or 20 mg kg(-1) day(-1) divided twice a day (BID) to compensate for progressively increasing caffeine metabolism...
July 27, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28749475/patient-care-standards-for-primary-mitochondrial-disease-a-consensus-statement-from-the-mitochondrial-medicine-society
#2
REVIEW
Sumit Parikh, Amy Goldstein, Amel Karaa, Mary Kay Koenig, Irina Anselm, Catherine Brunel-Guitton, John Christodoulou, Bruce H Cohen, David Dimmock, Gregory M Enns, Marni J Falk, Annette Feigenbaum, Richard E Frye, Jaya Ganesh, David Griesemer, Richard Haas, Rita Horvath, Mark Korson, Michael C Kruer, Michelangelo Mancuso, Shana McCormack, Marie Josee Raboisson, Tyler Reimschisel, Ramona Salvarinova, Russell P Saneto, Fernando Scaglia, John Shoffner, Peter W Stacpoole, Carolyn M Sue, Mark Tarnopolsky, Clara Van Karnebeek, Lynne A Wolfe, Zarazuela Zolkipli Cunningham, Shamima Rahman, Patrick F Chinnery
The purpose of this statement is to provide consensus-based recommendations for optimal management and care for patients with primary mitochondrial disease. This statement is intended for physicians who are engaged in the diagnosis and management of these patients. Working group members were appointed by the Mitochondrial Medicine Society. The panel included members with several different areas of expertise. The panel members utilized surveys and the Delphi method to reach consensus. We anticipate that this statement will need to be updated as the field continues to evolve...
July 27, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28749436/disparities-in-snacking-trends-in-us-adults-over-a-35-year-period-from-1977-to-2012
#3
Elizabeth K Dunford, Barry M Popkin
BACKGROUND: Previous studies have indicated that snacking is contributing to increased calories in the American diet, and that the contribution of snacks to energy intake has increased in recent decades. OBJECTIVE: The objective was to examine trends in the energy intake deriving from snacks and food sources of snacks for US adults over 35 years from 1977 to 2012, and whether these trends differ across sociodemographic groups. METHODS: Participants included 74,291 US adults aged ≥19 years who participated in the 1977-1978 Nationwide Food Consumption Survey (NFCS); the 1989-1991 Continuing Survey of Food Intake by Individuals (CSFII), the 1994-1996 CSFII, the 1997-1998 CSFII, National Health and Nutrition Examination Survey (NHANES) 2003-2004, NHANES 2005-2006, NHANES 2009-2010 and NHANES 2011-2012; all surveys are a stratified random sample of the total civilian, non-institutionalized US population...
July 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28749434/unsolved-puzzles-surrounding-hcv-immunity-heterologous-immunity-adds-another-dimension
#4
REVIEW
Babita Agrawal, Shakti Singh, Nancy Gupta, Wen Li, Satish Vedi, Rakesh Kumar
Chronic infection with hepatitis C virus (HCV) afflicts 3% of the world's population and can lead to serious and late-stage liver diseases. Developing a vaccine for HCV is challenging because the correlates of protection are uncertain and traditional vaccine approaches do not work. Studies of natural immunity to HCV in humans have resulted in many enigmas. Human beings are not immunologically naïve because they are continually exposed to various environmental microbes and antigens, creating large populations of memory T cells...
July 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28749377/optical-response-in-weyl-semimetal-in-model-with-gapped-dirac-phase
#5
Soumya Prasad Mukherjee, Jules P Carbotte
We study the optical properties of Weyl semimetal (WSM) in a model which features, in addition to the usual term describing isolated Dirac cones proportional to the Fermi velocity $v_{F}$, a gap term $m$ and a Zeeman spin-splitting term $b$ with broken time reversal symmetry. Transport is treated within Kubo formalism and particular attention is payed to the modifications that result from a finite $m$ and $b$. We consider how these modifications change when a finite residual scattering rate $\Gamma$ is included...
July 27, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28749359/systolic-time-interval-estimation-using-continuous-wave-radar-with-on-body-antennas
#6
Dilpreet Buxi, Evelien Hermeling, Marco Mercuri, Fabian Beutel, Roberto Garcia van der Westen, Tom Torfs, Jean-Michel Redoute, Mehmet Rasit Yuce
The estimation of systolic time interval (STI)s is done using continuous wave (CW) radar at 2.45GHz with an on-body antenna. MOTIVATION: In the state of the art, typically bioimpedance, heart sounds and / or ultrasound is used to measure STIs. All three methods suffer from insufficient accuracy of STI estimation due to various reasons. CW radar is investigated for its ability to overcome the deficiencies in the state of the art. METHODS: Ten healthy male subjects aged 25-45 were asked to lie down at a 30 degree incline...
July 25, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28749345/noise-in-neuronal-and-electronic-circuits-a-general-modeling-framework-and-non-monte-carlo-simulation-techniques
#7
Deniz Kilinc, Alper Demir
The brain is extremely energy efficient and remarkably robust in what it does despite the considerable variability and noise caused by the stochastic mechanisms in neurons and synapses. Computational modeling is a powerful tool that can help us gain insight into this important aspect of brain mechanism. A deep understanding and computational design tools can help develop robust neuromorphic electronic circuits and hybrid neuroelectronic systems. In this paper, we present a general modeling framework for biological neuronal circuits that systematically captures the nonstationary stochastic behavior of ion channels and synaptic processes...
August 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28749319/a-survey-exploring-national-health-service-eprescribing-toolkit-use-and-perceived-usefulness-amongst-english-hospitals
#8
Kathrin Cresswell, Ann Slee, Aziz Sheikh
BACKGROUND: There is currently limited guidance for hospitals to implement ePrescribing systems. We have developed an ePrescribing Toolkit designed to support ongoing implementation, adoption and optimisation of efforts. AIM: To investigate the perceived usefulness, reported use and areas for further development of the Toolkit by ePrescribing implementers in English hospitals. METHODS: Questionnaire-based survey of hospitals that have or are interested in implementing ePrescribing systems...
June 30, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28749265/emergency-anesthesia-and-exploratory-laparotomy-in-a-compromised-pacific-white-sided-dolphin-lagenorhynchus-obliquidens
#9
Justin F Rosenberg, Martin Haulena, James E Bailey, Dean A Hendrickson, Marina Ivančić, Stephen A Raverty
Anesthesia and surgery in cetaceans have inherent risks and have rarely been utilized as viable treatment options. This report represents the first known multidisciplinary team approach to emergency laparotomy in a compromised, 22-yr-old, female Pacific white-sided dolphin ( Lagenorhynchus obliquidens ). The inciting clinical signs and ancillary diagnostics were consistent with a mechanical ileus. Although no torsion or obstruction was apparent during surgery, severe enteritis and peritonitis were noted. Postoperatively, the animal was maintained on aggressive medical management with continuous supportive care until succumbing 3 days later with clinical pathology indicative of terminal sepsis and profound inflammation...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749249/an-autopsy-verified-case-of-steroid-responsive-encephalopathy-with-convulsion-and-a-false-positive-result-from-the-real-time-quaking-induced-conversion-assay
#10
Yuichi Hayashi, Yasushi Iwasaki, Nobuaki Yoshikura, Takahiko Asano, Maya Mimuro, Akio Kimura, Katsuya Satoh, Tetsuyuki Kitamoto, Mari Yoshida, Takashi Inuzuka
We report an autopsy-verified case of steroid-responsive encephalopathy with convulsion and a false-positive result from the real-time quaking-induced conversion (RT-QUIC) assay. A 61-year-old Japanese man presented with acute onset of consciousness disturbance, and convulsions, but without a past medical or family history of progressive dementia, epilepsy, or prion disease. Brain diffusion and fluid-attenuated inverted recovery MR images revealed edematous cortical hyper-intensity, which diminished after the acute phase...
July 27, 2017: Prion
https://www.readbyqxmd.com/read/28749247/evaluating-the-effectiveness-of-a-community-based-hygiene-promotion-program-in-a-rural-salvadoran-setting
#11
Elizabeth L Andrade, Jeffrey B Bingenheimer, Mark C Edberg, Kathryn L Zoerhoff, Emily M Putzer
There has been considerable progress in the reduction of diarrheal disease among children under five through health and nutrition interventions. However, diarrheal disease is still the second leading cause of child death worldwide. There is growing recognition that comprehensive hygiene behavior improvements should be integral to prevention efforts, but the effectiveness of different approaches for hygiene promotion is still being established. Hygiene risk practices vary across settings, suggesting that prevention strategies should be adapted to local contexts using community-based approaches...
July 1, 2017: Global Health Promotion
https://www.readbyqxmd.com/read/28749229/effects-of-a-support-program-on-nurses-communication-with-hospitalized-children-s-families
#12
Hiroko Hashimoto
More than a few pediatric nurses experience difficulty in communicating with children's family members. However, effective means of providing communication support for pediatric nurses have not been examined sufficiently. This study aimed to develop and implement a communication support program for nurses to facilitate improved communication with families of hospitalized children, and to clarify changes in nurses' recognition and behavior toward communication with families in clinical settings. The program lasted 6 months and consisted of lectures, role-play, 4 communication models in which nurses experienced difficulty communicating with family members, and continued individual support...
September 2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/28749212/safety-innovations-healthcare-system-takes-bold-step-with-continuous-monitoring
#13
Martha Vockley
No abstract text is available yet for this article.
July 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28749202/abbreviated-breast-mri-for-screening-women-with-dense-breast-the-ea1141-trial
#14
Christiane K Kuhl
Early diagnosis improves survival of women with breast cancer. Mammographic screening improves early diagnosis of breast cancer. And yet, there appears to be room for improvement. Major shortcomings of mammographic screening are overdiagnosis of prognostically unimportant cancer, as well as underdiagnosis of cancers that are indeed relevant. Failure to detect biologically relevant breast cancer with mammographic screening is driven by host-related factors, i.e. breast tissue density, but also tumour-related factors: Biologically relevant cancers may exhibit imaging features that renders them indistinguishable from normal or benign breast tissue on mammography...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28749197/cardiovascular-benefits-and-safety-of-non-insulin-medications-used-in-the-treatment-of-type-2-diabetes-mellitus
#15
Srikanth Yandrapalli, George Jolly, Adam Horblitt, Abdallah Sanaani, Wilbert S Aronow
Diabetes mellitus is a growing in exponential proportions. If the current growth trend continues, it may result in every third adult in the United States having diabetes mellitus by 2050, and every 10(th) adult worldwide. Type 2 diabetes mellitus (T2DM) confers a 2- to 3-fold increased risk of cardiovascular (CV) events compared with non-diabetic patients, and CV mortality is responsible for around 80% mortality in this population. Patients with T2DM can have other features of insulin resistance-metabolic syndrome like hypertension, lipid abnormalities, and obesity which are all associated with increased CV disease and stroke risk even in the absence of T2DM...
July 27, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28749140/geometric-dependent-drying-in-dead-end-nanochannels
#16
Quan Xie, Siyang Xiao, Chuanhua Duan
Liquid drying in nanoporous media is a key process in food, textile, oil and energy industries, but the corresponding kinetics remains poorly understood due to the structural complexity of nanoporous media. Here, we directly observe the drying process and study drying kinetics in single two-dimensional (2-D) nanochannels with height ranging from 29 nm to 122 nm. Two different drying behaviors are discovered in such nanoconfinements, continuous meniscus receding and discontinuous meniscus receding due to liquid bridge formation ahead of the meniscus, albeit similar drying rates...
July 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28749096/early-goal-directed-therapy-by-continuous-non-invasive-hemodynamic-monitoring-still-elusive
#17
Ole Broch, Matthias Gruenewald, Arne Carstens, Jochen Renner
No abstract text is available yet for this article.
July 26, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28749092/ketamine-for-depression-4-in-what-dose-at-what-rate-by-what-route-for-how-long-and-at-what-frequency
#18
Chittaranjan Andrade
BACKGROUND: Ketamine, administered in subanesthetic doses, is an effective off-label treatment for severe and even treatment-refractory depression; however, despite dozens of studies across nearly 2 decades of research, there is no definitive guidance on matters related to core practice issues. METHODS: This article presents a qualitative review and summary about what is known about ketamine dosing, rate of administration, route of administration, duration of treatment, and frequency of sessions...
July 25, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28749061/decision-making-for-an-incapacitated-pregnant-patient
#19
Hilary Mabel, Susannah L Rose, Eric Kodish
Decisions about continuing or terminating a pregnancy touch on profound, individualized questions about bodily integrity, reproductive autonomy, deeply held values regarding one's capacity for parenthood, and, in the case of a high-risk pregnancy, the risks one is willing to take to have a baby. So far as possible, reproductive decisions are made between a patient, in some cases her partner, and her medical provider. However, this standard framework cannot be applied if the patient lacks decision-making capacity...
July 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28748969/discovering-intratumor-heterogeneity-the-next-frontier-for-pathologists
#20
J I López, G De Petris
Discovering intratumor heterogeneity is a crucial issue in modern oncologic medicine. Highly sophisticated technology such as high-throughput DNA sequencing has demonstrated the real dimension of the problem. The overwhelming majority of malignant tumors show high levels of intratumor heterogeneity when thoroughly studied. Intratumor heterogeneity develops both in temporal and spatial domains and its distribution is not deterministic making each case truly unique and unrepeatable. Pathologists are main actors in intratumor heterogeneity detection since they are the medical specialists who sample the tumors...
June 2017: Pathologica
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