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Dharmender Rathee, Viney Lather, Ajmer Singh Grewal, Harish Dureja
One specific group of MMPs; gelatinases A (MMP-2) and B (MMP-9) are of precise interest in view of the development and progression of cancer. In the current work, an attempt was made to investigate the enzymatic inhibitory activity of Kutkin (KT), Kutkoside (KS), and Picroside I (PS) by inhibition assay and to further check the downregulation of the expression of mRNA levels of MMP-2 and -9. Further in silico docking studies were performed to investigate the interaction of KT, KS and PS with MMP-2 and MMP-9...
November 3, 2018: Computational Biology and Chemistry
Teodora Costea, Ariana Hudiță, Oana-Alina Ciolac, Bianca Gălățeanu, Octav Ginghină, Marieta Costache, Constanța Ganea, Maria-Magdalena Mocanu
Colorectal cancer is one of the leading causes of death, and the third most diagnosed type of cancer, worldwide. It is most common amongst men and women over 50 years old. Risk factors include smoking, alcohol, diet, physical inactivity, genetics, alterations in gut microbiota, and associated pathologies (diabetes, obesity, chronic inflammatory bowel diseases). This review will discuss, in detail, the chemopreventive properties of some dietary compounds (phenolic compounds, carotenoids, iridoids, nitrogen compounds, organosulfur compounds, phytosterols, essential oil compounds, polyunsaturated fatty acids and dietary fiber) against colorectal cancer...
November 28, 2018: International Journal of Molecular Sciences
Cheng-Gang Zhang, Ting Chen, Xu-Dong Mao, Sen-Miao Zhao, Gui-Xin Chou
Caryopincaolide M (1), a new rearranged abietane diterpenoid with an unusual pent-4-enoic acid group on a 6/6/5 tricyclic ring system, and 7-epi-8-dehydroxypatriscabrol (3), a new iridoid, together with 17 known compounds, have been isolated from the whole plant of Caryopteris incana (Thunb.) Miq. Their structures were elucidated on the basis of 1-D and 2-D NMR, IR, and mass spectroscopic data. Compounds 1-5 were evaluated for their inhibitory activities against enzyme α-glucosidase, and the results showed that only 1 has moderate inhibitory activity against enzyme α-glucosidase with IC50 at 528...
November 24, 2018: Journal of Natural Medicines
Tomoe Ohta, Tanatorn Tilkanont, Frederick Ayertey, Mina Nakagawa, Nguyen Huu Tung, Peter Bolah, Heron Blagogee, Alfred Ampomah Appiah, Augustine Ocloo, Mitsuko Ohashi, Kensuke Tanoue, Yasuchika Yamaguchi, Nobuo Ohta, Shoji Yamaoka, Shiro Iwanaga, Takuhiro Uto, Yukihiro Shoyama
A new high performance liquid chromatography (HPLC) method has been established for quantitative and qualitative analysis of three tetracyclic iridoids: ML-2-3 (1), molucidin (2), and ML-F52 (3), which are responsible for anti-trypanosomal and anti-leishmanial activities of Morinda lucida Bentham leaves. Separation of 1-3 from dried 80% aqueous (aq.) ethanol extract was achieved on a reversed-phase cholester column packed with cholesteryl-bonded silica using an acetonitrile-0.1% aq. formic acid mobile phase system...
October 29, 2018: Journal of Pharmaceutical and Biomedical Analysis
Ehab Mahran, Mohammed Hosny, Atef El-Hela, Arezue Boroujerdi
Six metabolites (1-6) were isolated from the aerial parts of Anarrhinum pubescens Fresen. (Plantaginaceae) growing in Saint Catherine region in Egypt; two of them (1 and 4) are here reported to be newly identified naturally occurring iridoids. The isolated metabolites were identified as 6-O-foliamenthoyl-(6'-O-cinnamoyl)-antirrhinoside (1), 6'-O-cinnamoyl-antirrhinoside (2), the iridoid dimer, pubescensoside (4), antirrhinoside (5), 10-hydroxy-antirrhinoside (6), and the flavonoid, diosmin (3). Identification of the new metabolites was based on analysis of their collected spectroscopic data (NMR and HR-ESI-MS)...
November 23, 2018: Natural Product Research
Li-Fang Liu, Ming-Jun Yao, Man-Yu Li, Xiao-Zhen Wu, Cheng-Shan Yuan
Three new iridoids, (rel-4aS,7S,7aS)-1,4a,5,6,7,7a-hexahydro-7-hydroxyl-7-methyl-cyclopenta[c]pyran-4-carboxaldehyde (1), 1,3,5,6-tetrahydro-1-methoxyl-7-methyl-cyclopenta[c]pyran-4-carboxaldehyde (2), and (rel-1R,4S,4aS,7R,7aR)-7-methylhexahydro-1,4-(epoxymethano)cyclopenta[c]pyran-3(1H)-one(3), together with seven known analogues, were isolated from the 95% EtOH extract of the whole plant of Pedicularis uliginosa Bunge.Their structures were elucidated via their extensive NMR spectroscopy and mass spectral data...
November 23, 2018: Chemistry & Biodiversity
Yan Zhang, Wei-Yu Zhou, Xiao-Yu Song, Guo-Dong Yao, Shao-Jiang Song
As a part of our ongoing search for neuroprotective compounds from natural products, two new iridoid glycosides, vibsansuspenside A-B (1-2), along with five known terpenoids (3-7), were isolated from the dry leaves of Viburnum odoratissimum. Their chemical structures were well determined by means of NMR spectroscopic data as well as HRESIMS analysis. All compounds were detected for their neuroprotective effects against H2 O2 -induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y). Among them, compound 3 displayed the most potent neuroprotective ability, and further investigation by Annexin V/PI and Western blot analysis demonstrated that compound 3 could protect SH-SY5Y cells from oxidative damage through inhibiting cell apoptosis...
November 10, 2018: Natural Product Research
Shao-Qing Yang, Ye-Dan Chen, Heng Li, Xian Hui, Wen-Yun Gao
BACKGROUND: Hepatic gluconeogenesis plays an important role in regulating fasting plasma glucose levels and is a target of anti-diabetic drugs. Several kinds of iridoid glucosides exhibit hypoglycemic effect, whereas the mechanism was not clear. AIM OF THE STUDY: In this study, the effects of geniposide and gentiopicroside, two natural iridoid glucosides, on hepatic gluconeogenesis were investigated. METHODS: Glucose uptake assay, MTT assay, q-PCR, luciferase assay and western blot assay were performed to investigate the pharmacological effect of geniposide and gentiopicroside on human liver cell line L02...
November 5, 2018: Archives of Medical Research
Xin Wang, Chong-Hui Liu, Jin-Jie Li, Bo Zhang, Lin-Lin Ji, Xiao-Ya Shang
Four new iridoid glycosides named cornusphenosides A-D (1-4) were isolated from an ethanol extract of the fruits of Cornus officinalis (shan zhu yu). The structures of these compounds were elucidated on the basis of spectroscopic data (UV, IR, HRESIMS, and 1D and 2D NMR) and chemical evidence. The neuroprotective effects of compounds 1-4 were also assessed in vitro.GRAPHICAL ABSTRACT[Formula: see text].
November 8, 2018: Journal of Asian Natural Products Research
Wen-Jing Liu, Yan Cao, Qing-Qing Song, Jian Zheng, Yun-Fang Zhao, Peng-Fei Tu, Jun Li, Yue-Lin Song
As a holoparasitic plant, Cistanche deserticola is one of the two original sources of Cistanches Herba that is one of the most famous tonic medicines, in Chinese Pharmacopoeia. The succulent stems are used for medicinal usage, whereas those lignified stems as well as flowers of less pharmacological importance are usually deserted, suggesting extensive resource waste. Herein, chemical characterization of the flowers along with lignified stems was conducted using HPLC-IT-TOF-MS aiming to explore the medicinal valu of those non-medicinal parts...
September 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Monika E Czerwińska, Anita Świerczewska, Sebastian Granica
The traditional role of Lamium album L. (white dead nettle, Lamiaceae) in providing relief from pain in rheumatism as well as vaginal and cervical inflammation was described. The aim of the study was to screen for the anti-inflammatory bioactivity of compounds isolated from aqueous-methanolic extract of Lamium album herb in human neutrophils (PMNs). The effect of the compounds on the inhibition of selected inflammatory markers released by neutrophils, such as cytokines (IL-8, TNF-α), was studied. The molecular masses and the purity of compounds were determined using high-performance liquid chromatography coupled with diode array detection and mass spectrometry (HPLC-DAD-MSn )...
October 25, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Pu-Yang Gong, Yu-Shan Tian, Yu-Jie Guo, Li-Fei Gu, Jun-Yi Li, Jin Qi, Bo-Yang Yu
ETHNOPHARMACOLOGICAL RELEVANCE: In traditional Chinese medicine (TCM), Rehmanniae Radix (RR, derived from the root of Rehmannia glutinosa(Gaertn.) DC.) is commonly used as natural medicine for thousands of years, two types including the dried and rice-wine processed RR were used for different clinical purposes respectively, which were the typical case that pharmaceutical effect changed by processing in TCM. AIM OF STUDY: The goal of this study was to investigate the differences in the antithrombosis and hematopoietic effects of extracts of dried and processed RR (DRR and PRR) in vivo, and to explore the chemical basis underlying changes of medicinal properties caused by processing...
October 22, 2018: Journal of Ethnopharmacology
Yi Shen, Qi Zhang, Yan-Bin Wu, Yu-Qiong He, Ting Han, Jian-Hua Zhang, Liang Zhao, Hsien-Yeh Hsu, Hong-Tao Song, Bing Lin, Hai-Liang Xin, Yun-Peng Qi, Qiao-Yan Zhang
BACKGROUND: Iridoid glycosides (IGs), including monotropein (MON) and deacetyl asperulosidic acid (DA) as the main ingredients, are the major chemical components in Morinda officinalis How. (MO) root, possessing various pharmacological properties including anti-osteoporosis, anti-inflammation and anti-rheumatism activities.The aim of the present study was to further elucidate the pharmacological actions of MO by investigating the pharmacokinetics and tissue distribution of IGs in MO. METHODS: An ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS) method was developed and validated for simultaneous determination of MON and DA levels in plasma and various tissues of Wistar rats...
October 24, 2018: BMC Complementary and Alternative Medicine
Janaína M de Ávila, Alessandra O Pereira, Lucimara L Zachow, Adriana Z Gehm, Maura Z Santos, Marco A Mostardeiro, Davi Back, Ademir F Morel, Ionara I Dalcol
Two new iridoids (1-2) and a new decomposition product of valepotriates (3), together with fifteen known compounds (4-18) were isolated from the roots and rhizomes of Valeriana polystachya Smith, a native species from the Pampa Biome. Their structures were elucidated by means of NMR spectroscopy, mass spectrometry and optical rotation. The structures of 3 and 18 were further confirmed by single crystal X-ray diffraction analysis. In the group of the isolated compounds, 6β-hydroxysitostenone, hydroxymaltol and isovillosol were isolated from the Valeriana genus for the first time...
October 16, 2018: Fitoterapia
Laura Hannemann, Calin Rares Lucaciu, Sapna Sharma, Thomas Rattei, Klaus F X Mayer, Alfons Gierl, Monika Frey
In the plant kingdom beta-glucosidases (BGLUs) of the glycosidase hydrolase family 1 have essential function in primary metabolism and are particularly employed in secondary metabolism. They are essential for activation in two-component defence systems based on stabilisation of reactive compounds by glycosylation. Based on de novo assembly we isolated and functionally characterised BGLUs expressed in leaves of Lamium galeobdolon (LgGLUs). LgGLU1 could be assigned to hydrolysis of the benzoxazinoid GDIBOA (2,4-dihydroxy-1,4-benzoxazin-3-one glucoside)...
December 2018: Phytochemistry
Ahmed Galal Osman, Zulfiqar Ali, Omer Fantoukh, Vijayasankar Raman, Ramsay S T Kamdem, Ikhlas Khan
Four ursane-type triterpenoid glycosides (1-4), two benzophenone glycosides (5 and 6), and one iridoid glucoside (7) were isolated and characterized from the dried roots of Vangueria agrestis. Compounds 1 (3-O-[α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl]pomolic acid 28-O-β-D-glucopyranosyl ester) and 5 (2-O-[β-D-apiofuranosyl-(1→6)-β-D-glucopyranosyl]-6,4'-dihydroxy-4-methoxy benzophenone) were found to be new metabolites. The identity of all compounds has been accomplished, primarily, based on 1 D and 2 D NMR and HRESMS analysis...
October 16, 2018: Natural Product Research
Zhengkai Wei, Kai Su, Peng Jiang, Mingyu Shi, Jingjing Wang, Guanghong Xie
Staphylococcus aureus (S.aureus), a Gram-positive organism, is a frequent cause of subclinical mastitis. Geniposide, an iridoid glucoside isolated from the fruits of Gardenia jasminoides, has been reported to exhibit antibacterial and anti-inflammatory properties. The ability of S. aureus internalizing into bovine mammary epithelial cells (bMEC) has been responsible for the establishment of the bovine mastitis. In this study, we evaluated the effect of geniposide on S. aureus internalization into bMEC and investigated the possible mechanism of action...
October 12, 2018: Microbial Pathogenesis
Huimin Hu, Changyuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhihao Liu, Kexin Liu, Xiaoyu Liu, Huijun Sun
Hyperhomocysteinemia (HHCY) has been recognized as an independent risk factor for atherosclerosis and plays a vital role in the development of atherosclerosis. Catalpol, an iridoid glucoside extracted from the root of Rehmannia glutinosa, can produce anti-inflammatory, anti-oxidant, anti-tumor, and dopaminergic neurons protecting effects. This study aimed to determine the protecting effects of catalpol against homocysteine (HCY)-induced injuries in human aortic endothelial cells (HAECs) and uncover the underlying mechanisms: 1...
October 12, 2018: Inflammation
Balraj Singh Gill, Richa Mehra, Navgeet, Sanjeev Kumar
Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Several bioactive compounds have been extracted from leaves, seeds, roots in form of volatile oils, flavonoids, lignans, iridoids, terpenes, and steroids...
October 11, 2018: Molecular Biology Reports
Diana C G A Pinto, Naima Rahmouni, Noureddine Beghidja, Artur M S Silva
The genus Scabiosa (family Caprifoliaceae) is considered large (618 scientific plant names of species) although only 62 have accepted Latin binominal names. The majority of the Scabiosa species are widely distributed in the Mediterranean region and some Scabiosa species are used in traditional medicine systems. For instance, Scabiosa columbaria L. is used traditionally against diphtheria while S. comosa Fisch. Ex Roem. and Schult. is used in Mongolian and Tibetan traditional medical settings to treat liver diseases...
October 9, 2018: Medicines (Basel, Switzerland)
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