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Noroska Gabriela Salazar Mogollón, Guilherme Lionello Alexandrino, José Rafael de Almeida, Zulay Niño-Ruiz, José Gregorio Peña-Delgado, Roldán Torres-Gutiérrez, Fabio Augusto
The current methodology used in quality control of Ecuadorian beverages such as Pájaro azúl, Puro and Pata de vaca is carried out by using conventional gas chromatography; however, it does not allow the fingerprinting of these Ecuadorian spirit beverages and their possible cases of adulteration. In order to overcome this drawback, comprehensive two-dimensional gas chromatography-mass spectrometry (GC × GC-MS) was combined with multivariate data analysis, revealing that compounds like citronellal, citronellol, geraniol, methyl anthranilate, (-)-trans-α-bergamotene, (-)-cis-α-bergamotene and D-limonene can be considered key elements for pattern recognition of these traditional beverages and product adulteration cases...
October 11, 2018: Chemistry Central Journal
Yu Lei, Peng Fu, Xie Jun, Peng Cheng
Geraniol is an acyclic isoprenoid monoterpene isolated from the essential oils of aromatic plants including Cinnamomum tenuipilum, Valeriana officinalis , and several other plants. The limited source of geraniol from plant isolation cannot fulfill the great demand from the flavor and fragrance industries, which require maximizing geraniol production through biotechnology processes. The diverse activities of geraniol suggested that geraniol could treat various diseases as a promising drug candidate. In order to evaluate the potential of geraniol applied in a clinical trial, this review aims at providing a comprehensive summary of the pharmacological effects of geraniol...
October 11, 2018: Planta Medica
Natalie Wiese, Juliane Fischer, Jenifer Heidler, Oleg Lewkowski, Jörg Degenhardt, Silvio Erler
Honey bees are highly prone to infectious diseases, causing colony losses in the worst case. However, they combat diseases through a combination of their innate immune system and social defence behaviours like foraging for health-enhancing plant products (e.g. nectar, pollen and resin). Plant secondary metabolites are not only highly active against bacteria and fungi, they might even enhance selective foraging and feeding decisions in the colony. Here, we tested six major plant terpenes and their corresponding acetates, characterizing six natural Thymus vulgaris chemotypes, for their antimicrobial activity on bacteria associated with European foulbrood...
October 2, 2018: Scientific Reports
Bruna Fernanda Murbach Teles Andrade, Lidiane Nunes Barbosa, Fernanda Cristina Bérgamo Alves, Ana Flávia Pereira Marques, Mariana Albano, Vera Lúcia Mores Rall, Holger Brüggemann, Ary Fernandes Júnior
OBJECTIVES: The human skin microbiota is mainly composed of bacteria belonging to the genera Staphylococcus, Cutibacterium, Micrococcus and Corynebacterium, but on the skin of the face and back, ca. 50% of the total microbiota is represented by the bacterium Cutibacterium acnes. The aim of this research was to evaluate the impact of C. martini EO and its major compound, geraniol, on C. acnes. METHODS: The minimum inhibitory concentration against C. acnes strains, phenotypic changes and responses of the proteome was determined...
September 13, 2018: Journal of Pharmacy and Pharmacology
Yue Huang, Xiao-Lin Yang, Yi-Hua Ni, Zheng-Min Xu
Background: Geraniol is a monoterpene alcohol that has anti-fungal, anti-cancer and anti-nociceptive properties, but its anti-allergic rhinitis (AR) property is unclear. Methods: In this study, the anti-inflammatory role and its possible mechanisms of geraniol in human mast cell line (HMC-1) cells stimulated by inflammatory trigger phorbol 12-myristate 13-acetate plus A23187 (PMACI), as well as in ovalbumin (OVA)-induced AR mice models were investigated. Results: PMACI results in a significant increase in the production of proinflammatory cytokines, such as TNF-α, IL-1β, MCP-1, IL-6 and as well as histamine...
2018: Drug Design, Development and Therapy
Minju Lee, Heehong Yang, Daesan Kim, Myungjae Yang, Tai Hyun Park, Seunghun Hong
We report a strategy for the human-like smelling of a rose scent utilizing olfactory receptor nanodisc (ND)-based bioelectronic nose devices. In this strategy, a floating electrode (FE)-based carbon nanotube (CNT) field effect transistor (FET) was functionalized with human olfactory receptor 1A2 (hOR1A2)-embedded NDs (hOR1A2NDs). The hOR1A2NDs responded to rose scent molecules specifically, which were monitored electrically using the underlying CNT-FET. This strategy allowed us to quantitatively assess the contents of geraniol and citronellol, the main components of a rose scent, as low as 1 fM and 10 fM, respectively...
September 17, 2018: Scientific Reports
Sherif T S Hassan, Kateřina Berchová-Bímová, Miroslava Šudomová, Milan Malaník, Karel Šmejkal, Kannan R R Rengasamy
Thymus bovei Benth. (TB) is an important plant in the traditional medicine of the Mediterranean region. This study investigates the health-promoting properties of TB essential oil (TB-EO) for its possible use in clinical practice with regards to its cytotoxic, anti-herpes simplex virus type 2 (HSV-2), and antihypertensive (through inhibition of human angiotensin-converting enzyme; ACE) properties. The phytochemical profile of EO (99.9%) was analyzed by Gas Chromatography with Flame-Ionization Detection (GC-FID) and Gas Chromatography-Mass Spectrometry (GC-MS)...
September 15, 2018: Journal of Clinical Medicine
Raquel Fontaneda, Francisco J Fañanás, Félix Rodríguez
An unprecedented biomimetic cationic cyclization reaction of an alkyne-containing geraniol-derived epoxide is used for the stereoselective synthesis of a novel enantiomerically pure scaffold that is easily transformed into a set of structurally diverse decalin derivatives with potential application in the synthesis of targeted natural products and/or natural-product-inspired new molecules.
September 27, 2018: Chemical Communications: Chem Comm
Mohamed Chafik Bourkaib, Harifeno Randriamalala, Lena Dettori, Catherine Humeau, Stephane Delaunay, Isabelle Chevalot, Yann Guiavarc'h
Data in this paper describes the catalytic performances, expressed in terms of conversion %, of geraniol and acetic acid to geranyl acetate, using the immobilized lipase B from Candida antarctica in packed bed reactors (PBR) using supercritical CO2 as a solvent. Readers will find data related to different Figures or equations of the article as well as supplementary data that will help to make the difference between flowrates of CO2 in a liquid state and corresponding flowrates of supercritical CO2 for various CO2 pressure and temperature combinations...
October 2018: Data in Brief
André Luis Menezes Carvalho, José Alexsandro Silva, Ana Amélia Moreira Lira, Ellen Denise Prado Almeida, Rogéria de Souza Nunes, Victor Hugo Vitorino Sarmento, Leiz Maria Costa Veras, José Roberto de Almeida Leite, Leila Bastos Leal, Davi Pereira de Santana
This study aimed to examine the influence of the combination of chemical enhancers and a microemulsion on the transdermal permeation of zidovudine (AZT). Ethanol, 1,8-cineole, and geraniol were incorporated in a microemulsion. The droplet size, zeta potential, rheology, and SAXS analysis were performed. The permeation enhancer effect was evaluated using pig ear skin. Snake skin (Boa constrictor) treated with the formulations was also used as a stratum corneum model and studied by attenuated total reflectance-infrared spectroscopy...
September 5, 2018: AAPS PharmSciTech
Kazuki Takahashi, Issei Terauchi, Marie Ono, Hiroshi Satoh, Makoto Ueda
Terpene alcohol is widely used in perfumes and is known to possess antibacterial activity. Moreover, in its glycosylated form, it can be applied as a nonionic surfactant in food, and in the pharmaceutical, chemical, cosmetic, and detergent industries. Presently, chemical production of terpene glucosides is hampered by high costs and low yields. Here, we investigated the microbial glucosylation of nerol (cis-3,7-dimethylocta-2,6-dien-1-ol), a component of volatile oils, by Agrobacterium sp. M-12 isolated from soil...
September 5, 2018: Bioscience, Biotechnology, and Biochemistry
Karamkolly R Rekha, Ramu Inmozhi Sivakamasundari
Dysfunction of autophagy, mitochondrial dynamics and endoplasmic reticulum (ER) stress are currently considered as major contributing factors in the pathogenesis of Parkinson's disease (PD). Accumulation of oxidatively damaged cytoplasmic organelles and unfolded proteins in the lumen of the ER causes ER stress and it is associated with dopaminergic cell death in PD. Rotenone is a pesticide that selectively kills dopaminergic neurons by a variety of mechanism, has been implicated in PD. Geraniol (GE; 3,7-dimethylocta-trans-2,6-dien-1-ol) is an acyclic monoterpene alcohol occurring in the essential oils of several aromatic plants...
October 2018: Neurochemical Research
Xi Tang, Ye-Lin Shao, Ya-Jie Tang, Wen-Wen Zhou
The grain contamination by Aspergillus spp. has been a serious issue. This study exhibited the excellent antifungal effects of the essential oil compounds (EOCs) geraniol and citral against common grain pathogens ( A. flavus and A. ochraceus ) in vitro and in situ. The inhibitory mechanisms were also evaluated from the perspective of cell membrane permeability, reactive oxygen species (ROS) generation, and Aspergillus spp. growth-related gene expression. Meanwhile, the combined effects of EOCs in the vapor phase and modified atmosphere packaging (MAP) were examined to find an alternative preservation method for controlling Aspergillus spp...
August 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Atsushi Usami, Masahito Ishikawa, Katsutoshi Hori
The biotransformation of citral, an industrially important monoterpenoid, has been extensively studied using many microbial biocatalysts. However, the metabolic pathways involved in its biotransformation are still unclear, because citral is a mixture of the trans-isomer geranial and the cis-isomer neral. Here, we applied the heterologous expression of geoA, a gene encoding geraniol dehydrogenase that specifically converts geraniol to geranial and nerol to neral, to identify the metabolic pathways involved in the biotransformation of citral...
August 10, 2018: Bioscience, Biotechnology, and Biochemistry
Bakht Zada, Chonglong Wang, Ji-Bin Park, Seong-Hee Jeong, Ju-Eon Park, Hawaibam Birla Singh, Seon-Won Kim
Background: Current petroleum-derived fuels such as gasoline (C5 -C12 ) and diesel (C15 -C22 ) are complex mixtures of hydrocarbons with different chain lengths and chemical structures. Isoprenoids are hydrocarbon-based compounds with different carbon chain lengths and diverse chemical structures, similar to petroleum. Thus, isoprenoid alcohols such as isopentenol (C5 ), geraniol (C10 ), and farnesol (C15 ) have been considered to be ideal biofuel candidates. NudB, a native phosphatase of Escherichia coli , is reported to dephosphorylate isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into isopentenol...
2018: Biotechnology for Biofuels
Simone Giacosa, Manuela Giordano, Mar Vilanova, Enzo Cagnasso, Susana Río Segade, Luca Rolle
BACKGROUND: Cane-cut on-vine withering is a grape dehydration technique used for dry and sweet wine production. The aim of this work was to study the influence of the cane-cut technique applied at harvest to Moscato bianco grapes during the on-vine withering process to produce dehydrated berries with a different chemical composition and a volatile profile. RESULTS: After 24 days of dehydration, an on-vine withering system using the cane-cut technique induced an increase in the total volatile content compared with grapes produced with a normal on-vine withering process...
July 25, 2018: Journal of the Science of Food and Agriculture
Sarma R Kumar, H B Shilpashree, Dinesh A Nagegowda
Catharanthus roseus is the sole source of two of the most important anticancer monoterpene indole alkaloids (MIAs), vinblastine and vincristine and their precursors, vindoline and catharanthine. The MIAs are produced from the condensation of precursors derived from indole and terpene secoiridoid pathways. It has been previously reported that the terpene moiety limits MIA biosynthesis in C. roseus . Here, to overcome this limitation and enhance MIAs levels in C. roseus , bifunctional geranyl(geranyl) diphosphate synthase [G(G)PPS] and geraniol synthase (GES) that provide precursors for early steps of terpene moiety (secologanin) formation, were overexpressed transiently by agroinfiltration and stably by Agrobacterium -mediated transformation...
2018: Frontiers in Plant Science
Ane C C Santos, Paulo F Cristaldo, Ana P A Araújo, Carlisson R Melo, Ana P S Lima, Emile D R Santana, Bruna M S de Oliveira, José W S Oliveira, Jodnes S Vieira, Arie F Blank, Leandro Bacci
The recent decline of Apis mellifera populations around the world has been subject of intense research due to ecological and economic damages resulting from the loss of pollination services. The intensive use of insecticides from the neonicotinoids group is among the possible causal factors of this decline, including also sub-lethal effects. However, the use of synthetic insecticides has been increased on a global scale in the recent decades. In order to evaluate an alternative to the use of neonicotinoids, this work investigated the effects of a bioinsecticide and its major compound on A...
November 15, 2018: Ecotoxicology and Environmental Safety
Ruchi Sharma, Rekha Rao, Sunil Kumar, Sheefali Mahant, Sarita Khatkar
Mosquito borne diseases such as malaria, filariasis, chikunguniya, yellow fever, dengue and Japanese encephalitis are the major cause of remarkable morbidity and mortality in livestock and humans worldwide. Since ancient times, aromatic plants are used for their medicinal value. Essential oils derived from these plants may be used as effective alternatives/adjuvents in pharmaceuticals, biomedical, cosmetic, food, veterinary and agriculture applications. These oils have also gained popularity and interest for prevention and treatment of various disorders...
July 17, 2018: Current Drug Discovery Technologies
Yolanda Bouzas-Cid, Emiliano Trigo-Córdoba, Elena Falqué, Ignacio Orriols, José M Mirás-Avalos
Concentrations of amino acids and volatile compounds of a given grapevine cultivar might be altered by inter-annual climate variability and management practices such as irrigation. These compounds determine, in part, aroma and sensory characteristics of wines. The current study aimed at assessing the amino acid profile of musts and wines and the volatile composition of wines from Vitis vinifera (L.) cultivar 'Godello' grown in the Ribeiro Designation of Origin (NW Spain) under rain-fed and supplementary irrigation (SI) conditions over three years (2012-2014)...
September 2018: Food Research International
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