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natriuretic peptide BNP

Sadia Shah, Md Sayeed Akhtar, Md Quamrul Hassan, Mohd Akhtar, Yam Nath Paudel, Abul Kalam Najmi
AIM: Epidermal growth factor receptor (EGFR) related reactive oxygen species (ROS) generation results in myocardial damage. We aimed to investigate the role of gefitinib (EGFR-tyrosine kinase inhibitor) in diabetic cardiomyopathy (DbCM). METHOD: DbCM was induced by injecting streptozotocin (55 mg/kg for 5 consecutive days) to C57/BL6 mice intraperitoneally. Diabetic C57/BL6 mice (fasting blood glucose level ≥ 250 mg/dl) were allocated into four study groups and treated with two doses of gefitinib (30 mg/kg and 350 mg/kg per day) as well as ramipril (3 mg/kg/day) for four weeks...
August 11, 2018: Life Sciences
Takatoyo Kiko, Akiomi Yoshihisa, Yuki Kanno, Tetsuro Yokokawa, Satoshi Abe, Makiko Miyata-Tatsumi, Tomofumi Misaka, Masayoshi Oikawa, Atsushi Kobayashi, Takafumi Ishida, Yasuchika Takeishi
Sarcoidosis is a systemic granulomatous disease including heart (cardiac sarcoidosis, CS). It has recently been reported that isolated CS, which presenting primarily cardiac symptoms without clinical evidence of sarcoid involvement in other organs. Diagnostic and prognostic biomarkers of CS, especially in isolated CS, have not yet been established.We studied plasma levels of angiotensin-converting enzyme (ACE), soluble interleukin-2 receptor (sIL-2R), B-type natriuretic peptide (BNP) and cardiac troponin I (cTnI) in consecutive 172 patients with diagnosed sarcoidosis...
August 11, 2018: International Heart Journal
Takashi Yokota, Arata Fukushima, Shintaro Kinugawa, Takahiro Okumura, Toyoaki Murohara, Hiroyuki Tsutsui
Hyperuricemia is an independent predictor of mortality in patients with chronic heart failure. The aim of the study is to determine whether a urate-lowering agent febuxostat, an inhibitor of xanthine oxidase, may improve the clinical outcomes in chronic heart failure patients with hyperuricemia when compared to conventional treatment. This multicenter, prospective, randomized, open-label, blinded endpoint study with a follow-up period of 24 weeks will enroll 200 Japanese chronic heart failure patients with hyperuricemia...
August 11, 2018: International Heart Journal
Rujie Qin, Akira Koike, Osamu Nagayama, Yuta Takayanagi, Longmei Wu, Isao Nishi, Yuko Kato, Akira Sato, Takeshi Yamashita, Kazutaka Aonuma, Masaki Ieda
Ventilation (VE) increases linearly with the increase of carbon dioxide output (VCO2) during cardiopulmonary exercise testing. VE-VCO2 slope rises in parallel with exercise intensity, reaches a turning point (called the RC point), then steepens because of respiratory compensation for lactic acidosis. While this RC point can be identified universally, it is undetectable in some patients. In this study we evaluated whether the respiratory compensation during exercise testing has clinical significance in cardiac patients...
August 12, 2018: Bioscience Trends
Wafaa S El-Sherbeny, Nesreen M Sabry, Radwa M Sharbay
BACKGROUND: Adjuvant trastuzumab improved overall survival and reduced the risk for disease recurrence in women with breast cancers, because of its potential cardiotoxicity, careful monitoring of left ventricular (LV) function during treatment is required. METHODS: This study investigates, whether myocardial strain imaging and level of N-terminal pro-brain natriuretic peptide (NT-pro BNP) could predict subsequent reduction in LVEF in breast cancer patients received adjuvant trastuzumab...
August 11, 2018: Journal of Echocardiography
Xiaoyu Du, Yulin Li, Yuan Wang, Hongzhao You, Peng Hui, Yang Zheng, Jie Du
AIMS: The long-term prognosis of ST-segment elevation myocardial infarction (STEMI) with acute heart failure (AHF) is poor. Identification of metabolic changes could provide understanding of the underlying pathological progress associated with adverse events in patients with STEMI and AHF. Therefore, the study aimed to identify new plasm metabolites associated with long-term adverse cardiovascular events in patients with STEMI and AHF. MATERIALS AND METHODS: Mass spectrometry measurements of 26 amino acids were performed in 138 patients with STEMI and AHF...
August 6, 2018: Life Sciences
G C M Linssen, T Jaarsma, H L Hillege, A A Voors, D J van Veldhuisen
AIMS: Concentrations of circulating B‑type natriuretic peptides provide important prognostic information in heart failure (HF) patients. We directly compared the prognostic performance of brain natriuretic peptide (BNP) versus N‑terminal-proBNP (NT-proBNP) measurements in a large population of HF patients at hospital discharge after an admission for decompensated HF. METHODS AND RESULTS: BNP and NT-proBNP were measured in 563 stable HF patients before discharge...
August 7, 2018: Netherlands Heart Journal
Yong-Zeng Chen, Fan Wang, Hai-Jun Wang, Hong-Bin Liu
Objective: To investigate the role of sphingosine-1-phosphate (S1P) and its receptors in cardiomyocyte autophagy, cardiomyocyte hypertrophy and cardiac function. Methods: Cardiomyocytes were isolated from neonatal Vista rats. Autophagy and hypertrophy of cardiomyocytes were induced via starvation culture and phenylephrine (PE), respectively, and S1P was used to treat the cardiomyocytes. The effect of S1P on cardiomyocyte autophagy was evaluated by the number of autophagosomes, the expression of autophagy-related proteins and autophagic marker genes in cardiomyocytes...
May 2018: Journal of Geriatric Cardiology: JGC
Alexander Riad, Stefan Gross, Jeannine Witte, Rico Feldtmann, Katharina B Wagner, Yvonne Reinke, Kerstin Weitmann, Klaus Empen, Daniel Beug, Dirk Westermann, Diana Lindner, Karin Klingel, Marcus Dörr, Wolfgang Hoffmann, Stephan B Felix
BACKGROUND: Myeloid differentiation factor-2 (MD-2) has been shown to be an important modulator of the innate immune system, but its role in cardiac diseases is unknown. We investigated whether MD-2 plays a role as risk predictor and contributor in dilated cardiomyopathy (DCM). METHODS AND RESULTS: We included 174 patients with reduced left ventricular (LV) ejection fraction (LVEF <45%) due to DCM. Coronary artery disease and severe valvular diseases were excluded in all patients by angiography or echocardiography...
June 13, 2018: International Journal of Cardiology
Wei-Wei Wang, Yu Wang
Peripartum cardiomyopathy (PPCM) is life-threatening and its diagnosis is a challenge. We highlight the clinical characteristics and bio-markers of PPCM and the proper differential diagnosis of peripartum dyspnea to aim to make an early diagnosis available.We analyzed 262 peripartum patients with dyspnea, and summed up the final diagnosis. The clinical data of the control group and the PPCM group as well as before and after the treatment of the PPCM group were compared.In total, 147 (56%) of the perinatal patients were physiologic dyspnea of pregnancy; only 11 (4%) patients met the PPCM diagnostic criteria...
August 2018: Medicine (Baltimore)
Jie Ren, Wei Liu, Guang-Cai Li, Meng Jin, Zhen-Xi You, Hui-Guo Liu, Yi Hu
Atorvastatin is proven to ameliorate cardiac hypertrophy induced by chronic intermittent hypoxia (CIH). However, little is known about the mechanism by which atorvastatin modulates CIH-induced cardiac hypertrophy, and whether specific hypertrophyrelated microRNAs are involved in the modulation. MiR-31 plays key roles in the development of cardiac hypertrophy induced by ischemia/hypoxia. This study examined whether miR-31 was involved in the protective role of atorvastatin against CIH-induced myocardial hypertrophy...
June 2018: Current medical science
Ping-Ping Liao, Li-Hua Liu, Bin Wang, Xin Fang, Shao-Qiong Zhou, Wei Li, Yan-Qing Zhang, Si-Ming Guan
Heart failure (HF) is the end stage of various kinds of cardiovascular diseases and leads to a high mortality worldwide. Numerous studies have demonstrated that frequencies of CD4+CD25+Foxp3+ regulatory T cells (Tregs) are reduced in HF patients and properly expanding Tregs attenuates HF progression. Histone deacetylase (HDAC) 9 has been revealed to contribute to several cardiovascular and cerebrovascular diseases. Plenty of studies showed that HDAC9 negatively regulated the number and function of Tregs. Thus, we aim to investigate the expression of HDAC 9 in patients with chronic heart failure (CHF) and the relationship among HDAC9, Tregs and CHF...
April 2018: Current medical science
Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Dan Gorfil, Michal Laniado-Schwartzman, Ran Kornwoski, Dan Aravot, Nader G Abraham, Michael Arad, Edith Hochhauser
BACKGROUND: Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus (DM2) are all linked to diabetic cardiomyopathy that lead to heart failure. Cardiomyopathy is initially characterized by cardiomyocyte hypertrophy, followed by mitochondrial dysfunction and fibrosis, both of which are aggravated by angiotensin. Caloric restriction (CR) is cardioprotective in animal models of heart disease through its catabolic activity and activation of the expression of adaptive genes...
August 2, 2018: Cardiovascular Diabetology
Juan Lizandro Rodríguez-Hernández, Fayna Rodríguez-González, Marta Riaño-Ruiz, Efrén Martínez-Quintana
INTRODUCTION: Hyperuricemia has been associated with cardiovascular risk factors but it remains controversial if uric acid is an independent predictor of cardiac mortality. METHODS: A total of 503 CHD patients (457 nonhypoxemic and 46 hypoxemic) and 772 control patients fulfilled inclusion criteria. Demographic, clinical, and analytical data [serum uric acid and 24h urine uric acid levels, N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), and C-reactive-protein (CRP) concentrations] were studied...
July 31, 2018: Congenital Heart Disease
Maria Pufulete, Rachel Maishman, Lucy Dabner, Julian P T Higgins, Chris A Rogers, Mark Dayer, John MacLeod, Sarah Purdy, William Hollingworth, Morten Schou, Manuel Anguita-Sanchez, Patric Karlström, Michael Kleiner Shochat, Theresa McDonagh, Angus K Nightingale, Barnaby C Reeves
BACKGROUND: We estimated the effectiveness of serial B-type natriuretic peptide (BNP) blood testing to guide up-titration of medication compared with symptom-guided up-titration of medication in patients with heart failure (HF). METHODS: Systematic review and meta-analysis of randomised controlled trials (RCTs). We searched: MEDLINE (Ovid) 1950 to 9/06/2016; Embase (Ovid), 1980 to 2016 week 23; the Cochrane Library; ISI Web of Science (Citations Index and Conference Proceedings)...
July 31, 2018: Systematic Reviews
Fan Yang, Roberta Iacobelli, Jian-Ming Wang, Fiore Salvatore Iorio
BACKGROUND: Assessment of cardiac function is crucial in pediatric patients undergoing cardiovascular surgery, monitoring cardiac output and changing hemodynamic conditions during surgery accordingly is important to improve post-surgical outcome. We aimed to measure cardiac index (CI) and maximal rate of the increase of left ventricular pressure dp/dt(max) with the pressure recording analytic method (PRAM, MostCare® ) and compared it with transthoracic echocardiographic cardiac index estimation in infants with transposition of the great arteries (TGA) undergoing surgical correction...
July 30, 2018: World Journal of Pediatrics: WJP
Takeshi Umazume, Takahiro Yamada, Satoshi Yamada, Satoshi Ishikawa, Itsuko Furuta, Hiroyuki Iwano, Daisuke Murai, Taichi Hayashi, Kazunori Okada, Mamoru Morikawa, Takashi Yamada, Kota Ono, Hiroyuki Tsutsui, Hisanori Minakami
Objective: This longitudinal study was performed to determine changes in echocardiography parameters in association with various biomarker levels in pregnancy/postpartum. Methods: Fifty-one healthy pregnant women underwent echocardiography with simultaneous determination of blood levels of five biomarkers at each of the first, second and third trimesters of pregnancy, immediately postpartum within 1 week after childbirth and approximately 1 month postpartum...
2018: Open Heart
Marek Sramko, Dan Wichterle, Vojtech Melenovsky, Janka Franekova, Marcell Clemens, Masato Fukunaga, Josef Kautzner
BACKGROUND: We investigated whether the increase of plasma natriuretic peptides (NPs) in atrial fibrillation (AF) is independent of the effect of AF on the left atrial (LA) hemodynamics. METHODS: Hemodynamically stable patients scheduled for AF ablation underwent assessment of B-type natriuretic peptide (BNP) and mid-regional pro-atrial natriuretic peptide (MR-proANP), echocardiography, and direct measurement of left atrial (LA) pressure. Concentrations of the NPs were compared between patients in AF (n = 31) and controls in sinus rhythm (SR; n = 31) who were matched for age, gender, heart rate, left ventricular ejection fraction, LA volume index, and directly measured mean LA pressure...
July 26, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Hans Persson, Erwan Donal, Lars H Lund, Dmitri Matan, Emmanuel Oger, Camilla Hage, Jean-Claude Daubert, Cecilia Linde
AIMS: To study prevalence and prognostic importance of diagnostic echocardiographic variables in patients with suspected heart failure with preserved ejection fraction (HFpEF) in the prospective KaRen register study. METHODS AND RESULTS: KaRen patients were included following an acute HF-presentation, using Framingham criteria, B-type natriuretic peptide (BNP) >100 ng/L or N-terminal pro-BNP (NT-pro-BNP) >300 ng/L, and left ventricular (LV) ejection fraction ≥45%...
June 20, 2018: International Journal of Cardiology
Junhai Zhen, Li Li, Jing Yan
Sepsis is a common disease in critical patients, which may lead to myocardial damage, thereby aggravating the severity of the patients' condition, and causing adverse prognosis. How to detect sepsis with myocardial injury as early as possible, and use corresponding treatment measures on time are essential. Cardiac troponin I (cTnI), brain natriuretic peptide (BNP), myoglobin (Mb), MB isoenzyme of creatine kinase (CK-MB) and other traditional cardiac markers are easily affected by the complications of other critical diseases, thus the diagnostic value of those markers for myocardial injury of sepsis is reduced...
July 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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