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natriuretic peptide BNP

David Rodriguez, Gerardo Garcia-Rivas, Estibalitz Laresgoiti-Servitje, Jesus Yañez, Guillermo Torre-Amione, Carlos Jerjes-Sanchez
OBJECTIVE: To define and compare the reference interval of B-type natriuretic peptide (BNP) in healthy newborns (HN) from healthy mothers and with severe pre-eclampsia. DESIGN: Prospective, multicentre, cross-sectional study. SETTING: Four obstetric wards of second-level academic hospitals. PARTICIPANTS: 167 HN, from 146 healthy and 21 severe pre-eclamptic women. We included newborns from healthy mothers with full-term pregnancies (38 to 42 gestational weeks), who received adequate prenatal care and who had Apgar scores ≥7 at 0 and 5 min...
October 17, 2018: BMJ Open
Brian Lilleness, Frederick L Ruberg, Roberta Mussinelli, Gheorghe Doros, Vaishali Sanchorawala
Immunoglobulin light chain amyloidosis (AL amyloidosis) is caused by misfolded light chains which form soluble toxic aggregates that deposit in tissues and organs leading to organ dysfunction. The leading determinant of survival is cardiac involvement. Current staging systems use N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponins (TnT and TnI) for prognostication, but many centers do not offer NT-proBNP. We sought to derive a new staging system using brain natriuretic peptide (BNP) that would correlate with the Mayo 2004 staging system and be predictive for survival in AL amyloidosis...
October 17, 2018: Blood
Rufang Zhang, Jin Gong, Shouqing Wang, Li Shen, Yewei Xie, Xiaobing Li
The aim of this study was to investigate the role of B7-H3 in prognosis of congenital heart disease (CHD) children patients. A total of 65 CHD patients within age 3-12 years who went to our hospital were included during August 2011 to December 2012. Demographic data including age, sex, weight, clinical basic information such as New York Heart Association (NYHA) class, pathological type were collected. Blood samples were collected and serum levels of B7-H3, C-reactive protein (CRP), N-Terminal Pro-Brain Natriuretic Peptide (NT-pro-BNP), and High-sensitivity Troponin T (hsTnT) were determined by enzyme-linked immunosorbent assay (ELISA)...
October 17, 2018: Pediatric Cardiology
Wei Xiong, Yunfeng Zhao, Mei Xu, Bigyan Pudasaini, Xuejun Guo, Jinming Liu
BACKGROUND: Risk assessment of pulmonary arterial hypertension (PAH) contributes to its management. Unfortunately, the existing risk assessment approaches are defective for clinicians to practice in daily clinical settings to some extent. METHODS: We designed a modified Risk Assessment Score of PAH (mRASP) comprising four non-invasive variables which were World Health Organization functional class(WHO FC), 6-min walk distance (6MWD), N-terminal of the pro-hormone brain natriuretic peptide(NT-pro BNP), and right atrial area(RAA), then validated it in the prediction of one-year survival rate for patients with PAH by contrast with the REVEAL risk score...
October 16, 2018: BMC Pulmonary Medicine
Julie L Hejl, Mia K Grand, Volkert Siersma, Jens P Goetze, Niels de Fine Olivarius, Christen L Andersen, Bent Lind
BACKGROUND: Measurement of B-type natriuretic peptide (BNP) in plasma may have its greatest potential in primary care, as general practitioners need to rapidly identify patients who warrant further medical review. The aim of the present study was to examine the prognostic information of BNP measurement on all-cause mortality in a large Danish primary care cohort. METHODS: This study covered a cohort of Danish primary care patients (n = 61665) with a median follow-up period of 4...
October 15, 2018: Clinical Chemistry
Konstantinos Tselios, Mery Deeb, Dafna D Gladman, Paula Harvey, Shadi Akhtari, Susanna Mak, Jagdish Butany, Murray B Urowitz
OBJECTIVE: Antimalarials (AM) are recommended for all systemic lupus erythematosus (SLE) patients without specific contraindications. Their main adverse effect is retinal damage; however, heart disease has been described in isolated cases. The aim of our study is to describe 8 patients with AM-induced cardiomyopathy (AMIC) in a defined SLE cohort. METHODS: Patients attending the Toronto Lupus Clinic and diagnosed with definite (based on endomyocardial biopsy; EMB) and possible AMIC were included [based on cardiac magnetic resonance imaging (cMRI) and other investigations]...
October 15, 2018: Journal of Rheumatology
Iwona Grabowska, Neha Sharma, Alina Vasilescu, Madalina Iancu, Gabriela Badea, Rabah Boukherroub, Satishchandra Ogale, Sabine Szunerits
Rapid and accurate diagnostic technologies for early-state identification of cardiovascular abnormalities have become of high importance to prevent and attenuate their progression. The capability of biosensors to determine an increase in the concentration of cardiovascular protein biomarkers in circulating blood immediately after a myocardial infarction makes them ideal point-of-care platforms and alternative approaches to electrocardiograms, chest X-rays, and different laboratory-based immunoassays. We report here a generic approach toward multianalyte sensing platforms for cardiac biomarkers by developing aptamer-based electrochemical sensors for brain natriuretic peptide (BNP-32) and cardiac troponin I (cTnI)...
September 30, 2018: ACS Omega
Hongsheng Ren, Bo Song, Pengcheng Li, Cheng Huan, Yufeng Chu, Min Ding, Yuping Wang, Qingchun Yao, Peng Wang, Guoqiang Qi, Chunting Wang
Background: We explored the effects of high-volume hemofiltration(HVHF) by different ultrasound directing on the plasma N-terminal pro-B-type natriuretic peptide(NT-Pro-BNP), extra vascular lung water index (EVLWI), liquid net balance quantity and prognosis in patients with septic shock. Methods: Overall, 107 intensive patients with septic shock were enrolled by retrospective analysis from Department of Intensive Care Unit (ICU) of the Shandong Provincial Hospital affiliated to Shandong University from 2014-2017...
September 2018: Iranian Journal of Public Health
Cheng Zheng, Jia-Feng Lin, Zhong-Hao Lin, Wei-Qian Lin, Saroj Thapa, Yuan-Zheng Lin, Hao Lian, Zhi-Rui Liu, Jia-Hui Chen, Xiao-Wei Li
With the chronic ischemia persisting after acute myocardial infarction, the accompanying low-degree inflammation and subsequent fibrosis result in progression of cardiac remodeling and heart failure. Recently, Sodium Houttuyfonate (SH), a pure compound extracted from Houttuynia cordata , has been confirmed exerting anti-inflammatory and anti-fibrotic effects under diseased situations. Here, we aimed to investigate whether SH could reverse the cardiac remodeling post-myocardial infarction by alleviating cardiac inflammation and fibrosis...
2018: Frontiers in Pharmacology
Angela M Gallagher, Rebecca Lucas, Martin R Cowie
AIMS: Improving quality of life (QoL) in heart failure patients is a key management objective. Validated health-related QoL (HR-QoL) measurement tools have been incorporated into clinical trials but not routinely into daily practice. The aims of this study were to investigate the acceptability and feasibility of implementing validated HR-QoL instruments into heart failure clinics and to examine the impact of patient characteristics on HR-QoL. METHODS AND RESULTS: One hundred and sixty-three patients attending heart failure clinics at a UK tertiary centre were invited to complete three HR-QoL assessments: the Minnesota Living with Heart Failure Questionnaire (MLHFQ); the EuroQoL 5D-3L (EQ-5D-3L); and the Kansas City Cardiomyopathy Questionnaire (KCCQ) in that order...
October 11, 2018: ESC Heart Failure
Ajay Godwin Potnuri, Lingesh Allakonda, Arulvelan Appavoo, Sherin Saheera, Renuka R Nair
The association of histamine with adverse cardiac remodeling in chronic pressure overload has not received much attention. A pilot study in spontaneously hypertensive rats (SHRs) indicated a reduction of left ventricular hypertrophy (LVH) with a histamine-2-receptor (H2R) antagonist (famotidine). This finding prompted a detailed investigation of temporal variation in myocardial histamine and H2R expression and the cardiovascular response to H2R antagonism compared with that of the conventional beta-blocker metoprolol...
October 11, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Fumitaka Soga, Hidekazu Tanaka, Kazuhiro Tatsumi, Yasuhide Mochizuki, Hiroyuki Sano, Hiromi Toki, Kensuke Matsumoto, Junya Shite, Hideyuki Takaoka, Tomofumi Doi, Ken-Ichi Hirata
BACKGROUND: The objective of this study was to investigate the impact of sodium glucose cotransporter type 2 (SGLT2) inhibitors on left ventricular (LV) diastolic function of type 2 diabetes mellitus (T2DM) patients with heart failure (HF). METHODS: This trial was a prospective multicenter study of 58 T2DM patients with stable HF at five institutions in Japan. Patients who had been taking at least one antidiabetic drugs other than SGLT2 inhibitors started the administration of 5 mg/day of dapagliflozin...
October 8, 2018: Cardiovascular Diabetology
Michel Galinier, Eve Cariou, Olivier Lairez, Pauline Fournier, Clément Delmas, Caroline Biendel-Picquet, Jérôme Roncalli
Diagnosis of heart failure is too late. Symptoms of heart failure are non-specific. Brain natriuretic peptides allow the diagnosis of heart failure in pauci-symptomatic patients, with a threshold of 35pg/mL for BNP and 125pg/mL for NT-proBNP. Left ventricular dysfunction, either diastolic or systolic, remains asymptomatic for a long time. In diabetic and/or hypertensive patients, natriuretic peptides, can be used to diagnose asymptomatic left ventricular dysfunction, with a threshold of 125pg/mL NT-proBNP. Treatment blocking the renin-angiotensin-aldosterone system in diabetic patients with NT-proBNP levels of 125pg/mL can prevent onset of heart failure...
October 4, 2018: La Presse Médicale
Ismail Erturk, Kenan Saglam, Sadi Elasan, Musa B Aykan, Ramazan Acar, Fatih Yesildal, Fevzi N Aydin, Taner Ozgurtas
To investigate the clinical significance of VEGF, sVEGFR-1 in heart failure reduced ejection fraction (HFrEF) and heart failure mid-range ejection fraction (HFmrEF) patients. Methods: A total of 104 people consisting of HFrEF and HFmrEF patients (n=54) and healthy (n=50) subjects were included in this comparative cross-sectional study. The study took place in Gulhane Training and Research Hospital, Ankara, Turkey, between  2011 and 2013. Serum VEGF, sVEGFR-1, plasma pro-BNP analysis and transthoracic echocardiography were performed...
October 2018: Saudi Medical Journal
Mizuri Taki, Satoshi Hoshide, Ken Kono, Kazuomi Kario
Background: The measurements of B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are useful for ruling out heart failure and as prognostic markers in not only heart failure populations but also general populations. It is not clear whether these two biomarkers are elevated in parallel or associated with demographic characteristics in large populations at risk of stage A heart failure. Here we investigated the relationship between BNP and NT-proBNP and extended the evaluation of this association to known demographic disparities in stage A heart failure...
July 2018: Pulse (Basel, Switzerland)
Midori Miyazaki, Hidetoshi Hattori, Atsushi Suzuki, Naoki Serizawa, Kenta Uto, Kenji Fukushima, Mitsuru Momose, Tsuyoshi Shiga, Nobuhisa Hagiwara
A 60-year-old man with eosinophilic granulomatosis with polyangiitis (EGPA), which was diagnosed 12 years earlier and managed with prednisolone, was admitted to our hospital because of dyspnea and paresthesias in both hands. Laboratory test revealed peripheral eosinophilia along with elevated troponin T and brain natriuretic peptide (BNP). The patient's clinical picture was consistent with myocarditis and relapse of EGPA. Endomyocardial biopsy showed marked infiltration of eosinophils in myocardium, which confirmed relapse of EGPA with myocarditis...
October 2018: Journal of Cardiology Cases
Pierantonio Menna, Emanuela Salvatorelli, Grazia Armento, Ombretta Annibali, Carlo Greco, Francesco Marchesi, Vito Calabrese, Giorgio Reggiardo, Giorgio Minotti
We reported that cancer patients treated by anthracycline-based or nonanthracycline chemotherapy developed an early impairment of myocardial relaxation at echocardiography or persistent elevations of the cardiac hormone, B-type natriuretic peptide (BNP). Post hoc pharmacologic analyses showed that BNP elevations were induced by impaired relaxation and caused positive lusitropic effects that maintained a normal relaxation. High BNP and impaired relaxation were therefore characterized as mutually exclusive manifestations of diastolic dysfunction but high BNP caused positive chronotropism and inappropriate tachycardia...
October 1, 2018: Journal of Pharmacology and Experimental Therapeutics
Mladjan Golubovic, Dragana Stanojevic, Milan Lazarevic, Velimir Peric, Tomislav Kostic, Miodrag Djordjevic, Sasa Zivic, Dragan J Milic
Introduction: The Revised Cardiac Risk Index (RCRI) is an extensively used simple risk stratification tool advocated by the European Society of Cardiology and European Society of Anesthesiology (ESC/ESA). Purpose: The aim of this study was to find the best model for predicting 3-month cardiovascular complications in elective major vascular surgical patients using preoperative clinical assessment, calculation of the RCRI and Vascular Physiological and Operative Severity Score for the enumeration of mortality and morbidity (V-POSSUM) scores, and the preoperative levels of N-terminal brain natriuretic peptide (NT pro-BNP), high-sensitivity troponin I (hs TnI), and high-sensitivity C-reactive protein (hs CRP)...
2018: BioMed Research International
Xiaoyi Zhang, Yong Ye, Chunjie Yang, Hui Gong, Yang Li, Guoping Zhang, Jie Yuan, Yunzeng Zou
We aimed to study urotensin II (UII) in acute myocardial infarction (AMI) patients before and after percutaneous coronary intervention (PCI) and to investigate its interaction with angiotensin II (ATII) in post-AMI myocardial remodeling. In this clinical study, 63 AMI patients and 66 controls were included. Levels of UII, ATII, and NT-B-type natriuretic peptide (NT-BNP) were determined. Participants were followed up for 2 years to observe clinical outcomes. In cell biology experiments, ATII and UII were added into cardiomyocytes and fibroblasts individually or in combination...
August 2018: Discovery Medicine
Marzia Testa, Gian Luca Rosso, Cinzia Ferreri, Mauro Feola
Galectin-3 is demonstrated to be a robust independent marker of cardiovascular mid-term (18-month) outcomes in heart failure (HF) patients. The aim of this study was to analyze the value of a pre-discharged determination of galectin-3 alone and with brain natriuretic peptide (BNP) in predicting mid-term outcomes in elderly patients (>70 years old) discharged after an acute decompensated HF (ADHF) episode. METHODS: all elderly (≥70 years old) HF subjects discharged alive after an ADHF were enrolled...
September 27, 2018: Diseases (Basel)
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