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Evolutionary medicine

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https://www.readbyqxmd.com/read/28533660/genes-emotions-and-gut-microbiota-the-next-frontier-for-the-gastroenterologist
#1
REVIEW
Arturo Panduro, Ingrid Rivera-Iñiguez, Maricruz Sepulveda-Villegas, Sonia Roman
Most medical specialties including the field of gastroenterology are mainly aimed at treating diseases rather than preventing them. Genomic medicine studies the health/disease process based on the interaction of the human genes with the environment. The gastrointestinal (GI) system is an ideal model to analyze the interaction between our genes, emotions and the gut microbiota. Based on the current knowledge, this mini-review aims to provide an integrated synopsis of this interaction to achieve a better understanding of the GI disorders related to bad eating habits and stress-related disease...
May 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28529232/backwards-medicine-female-atavism-whiteness-and-the-medical-profession-in-the-pineal-eye
#2
Deanna Gross Scherger
This article examines atavism as a theory of racial science in the nineteenth-century United States that illuminates how the developing medical profession reinforced racial, class, and gender hierarchies to gain cultural authority. I use John S. Partridge's "The Pineal Eye," a little-known short story published in San Francisco's The Wave in 1894, as a case study that reveals how atavism was conceived as pathology within the purview of medical study. Partridge intertwines established atavistic discourse that asserted the Anglo-Saxon female body as paradoxically modern in terms of racial identity and primitive in terms of sex with scientific experimentation and male medical authority, resulting in evolutionary regression...
2017: Literature and Medicine
https://www.readbyqxmd.com/read/28496978/erratum-evolutionary-medicine-why-do-humans-get-bunions
#3
(no author information available yet)
[This corrects the article DOI: 10.1093/emph/eox001.].
2017: Evolution, Medicine, and Public Health
https://www.readbyqxmd.com/read/28494039/top-cited-articles-in-implant-dentistry
#4
Anastasia Fardi, Konstantinos Kodonas, Theodoros Lillis, Alexander Veis
PURPOSE: Citation analysis is the field of bibliometrics that uses citation data to evaluate the scientific recognition and the influential performance of a research article in the scientific community. The aim of this study was to conduct a bibliometric analysis of the top-cited articles pertaining to implant dentistry, to analyze the main characteristics, and to display the most interesting topics and evolutionary trends. MATERIALS AND METHODS: The 100 top-cited articles published in "Dentistry, Oral Surgery, and Medicine" journals were identified using the Science Citation Index Database...
May 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28492066/progression-inference-for-somatic-mutations-in-cancer
#5
Leif E Peterson, Tatiana Kovyrshina
Computational methods were employed to determine progression inference of genomic alterations in commonly occurring cancers. Using cross-sectional TCGA data, we computed evolutionary trajectories involving selectivity relationships among pairs of gene-specific genomic alterations such as somatic mutations, deletions, amplifications, downregulation, and upregulation among the top 20 driver genes associated with each cancer. Results indicate that the majority of hierarchies involved TP53, PIK3CA, ERBB2, APC, KRAS, EGFR, IDH1, VHL, etc...
April 2017: Heliyon
https://www.readbyqxmd.com/read/28481398/evolutionary-trade-offs-in-kidney-injury-and-repair
#6
REVIEW
Yutian Lei, Hans-Joachim Anders
Evolutionary medicine has proven helpful to understand the origin of human disease, e.g. in identifying causal roles of recent environmental changes impacting on human physiology (environment-phenotype mismatch). In contrast, diseases affecting only a limited number of members of a species often originate from evolutionary trade-offs for usually physiologic adaptations assuring reproductive success in the context of extrinsic threats. For example, the G1 and G2 variants of the APOL1 gene supporting control of Trypanosoma infection come with the trade-off that they promote the progression of kidney disease...
May 8, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28475810/draft-genome-sequence-of-the-tibetan-medicinal-herb-rhodiola-crenulata
#7
Yuanyuan Fu, Liangwei Li, Shijie Hao, Rui Guan, Guangyi Fan, Chengcheng Shi, Haibo Wan, Wenbin Chen, He Zhang, Guocheng Liu, Jihua Wang, Lulin Ma, Jianling You, Xuemei Ni, Zhen Yue, Xun Xu, Xiao Sun, Xin Liu, Simon Ming-Yuen Lee
Background: Rhodiola crenulata , a well-known medicinal Tibetan herb, is mainly grown in high-altitude regions of Tibet, Yunnan and Sichuan provinces in China. In the past few years increasing numbers of studies have been published on the potential pharmacological activities of R. crenulata , strengthening our understanding into its putitive active ingredient composition, pharmacological activity and mechanism of action. These findings also provide strong evidence supporting the important medicinal and economical value of R...
May 5, 2017: GigaScience
https://www.readbyqxmd.com/read/28470161/-evolutionary-concept-analysis-of-spirituality
#8
Il Sun Ko, So Young Choi, Jin Sook Kim
PURPOSE: This study was done to clarify attributes, antecedents, and consequences of spirituality. METHODS: Rodgers's evolutionary concept analysis was used to analyze fifty seven studies from the literature related to spirituality as it appears in systematic literature reviews of theology, medicine, counseling & psychology, social welfare, and nursing. RESULTS: Spirituality was found to consist of two dimensions and eight attributes: 1) vertical dimension: 'intimacy and connectedness with God' and 'holy life and belief', 2) horizontal dimension: 'self-transcendence', 'meaning and purpose in life', 'self-integration', and 'self-creativity' in relationship with self, 'connectedness' and 'trust' in relationship with others·neighbors·nature...
April 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28459453/the-nephila-clavipes-genome-highlights-the-diversity-of-spider-silk-genes-and-their-complex-expression
#9
Paul L Babb, Nicholas F Lahens, Sandra M Correa-Garhwal, David N Nicholson, Eun Ji Kim, John B Hogenesch, Matjaž Kuntner, Linden Higgins, Cheryl Y Hayashi, Ingi Agnarsson, Benjamin F Voight
Spider silks are the toughest known biological materials, yet are lightweight and virtually invisible to the human immune system, and they thus have revolutionary potential for medicine and industry. Spider silks are largely composed of spidroins, a unique family of structural proteins. To investigate spidroin genes systematically, we constructed the first genome of an orb-weaving spider: the golden orb-weaver (Nephila clavipes), which builds large webs using an extensive repertoire of silks with diverse physical properties...
June 2017: Nature Genetics
https://www.readbyqxmd.com/read/28453650/plantismash-automated-identification-annotation-and-expression-analysis-of-plant-biosynthetic-gene-clusters
#10
Satria A Kautsar, Hernando G Suarez Duran, Kai Blin, Anne Osbourn, Marnix H Medema
Plant specialized metabolites are chemically highly diverse, play key roles in host-microbe interactions, have important nutritional value in crops and are frequently applied as medicines. It has recently become clear that plant biosynthetic pathway-encoding genes are sometimes densely clustered in specific genomic loci: biosynthetic gene clusters (BGCs). Here, we introduce plantiSMASH, a versatile online analysis platform that automates the identification of candidate plant BGCs. Moreover, it allows integration of transcriptomic data to prioritize candidate BGCs based on the coexpression patterns of predicted biosynthetic enzyme-coding genes, and facilitates comparative genomic analysis to study the evolutionary conservation of each cluster...
April 27, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28444606/species-evolution-and-quality-evaluation-of-four-coptis-herbal-medicinal-materials-in-southwest-china
#11
Hanting Chen, Gang Fan, Yang He
Coptis herbs, which are important herbal medicinal materials, are the dried rhizomes of various plants. In China's herbal market, drying herbs can severely influence morphological markers such as shape, color, and odor, which make consumers difficult to precisely identify the herbs and effectively evaluate the quality. Here, we present the phylogenetic analysis of four Coptis herbal medicinal materials based on internal transcribed spacer sequences. C. chinensis, C. omeiensis, C. deltoidea and C. teeta constituted a monophyletic group...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28444439/back-to-the-future-part-2-post-mortem-assessment-and-evolutionary-role-of-the-bio-medicolegal-sciences
#12
REVIEW
Santo Davide Ferrara, Giovanni Cecchetto, Rossana Cecchi, Donata Favretto, Silke Grabherr, Takaki Ishikawa, Toshikazu Kondo, Massimo Montisci, Heidi Pfeiffer, Maurizio Rippa Bonati, Dina Shokry, Marielle Vennemann, Thomas Bajanowski
Part 2 of the review "Back to the Future" is dedicated to the evolutionary role of the bio-medicolegal sciences, reporting the historical profiles, the state of the art, and prospects for future development of the main related techniques and methods of the ancillary disciplines that have risen to the role of "autonomous" sciences, namely, Genetics and Genomics, Toxicology, Radiology, and Imaging, involved in historic synergy in the "post-mortem assessment," together with the mother discipline Legal Medicine, by way of its primary fundament, universally denominated as Forensic Pathology...
April 25, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28439010/cyclops-reveals-human-transcriptional-rhythms-in-health-and-disease
#13
Ron C Anafi, Lauren J Francey, John B Hogenesch, Junhyong Kim
Circadian rhythms modulate many aspects of physiology. Knowledge of the molecular basis of these rhythms has exploded in the last 20 years. However, most of these data are from model organisms, and translation to clinical practice has been limited. Here, we present an approach to identify molecular rhythms in humans from thousands of unordered expression measurements. Our algorithm, cyclic ordering by periodic structure (CYCLOPS), uses evolutionary conservation and machine learning to identify elliptical structure in high-dimensional data...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28438353/the-role-of-vitamin-d-in-the-immune-system-as-a-pro-survival-molecule
#14
REVIEW
Salvatore Chirumbolo, Geir Bjørklund, Andrea Sboarina, Antonio Vella
PURPOSE: Vitamin D is a fascinating and attractive molecule that has gained particular attention in medicine in recent years. Its immunomodulatory and anti-inflammatory potential might resemble the activity of many nature-derived molecules (eg, flavonoids), but its role in biology was selected during a long evolutionary pathway to dampen the damaging effect of cell stress response and of the immune reaction. In this sense, this molecule can be considered an ancient hormone that serves, in its primary role, as a pro-survival agent...
April 21, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28432115/effects-of-exercise-on-vascular-function-structure-and-health-in-humans
#15
Daniel J Green, Kurt J Smith
Physical activity has profound impacts on the vasculature in humans. Acute exercise induces immediate changes in artery function, whereas repeated episodic bouts of exercise induce chronic functional adaptation and, ultimately, structural arterial remodeling. The nature of these changes in function and structure are dependent on the characteristics of the training load and may be modulated by other factors such as exercise-induced inflammation and oxidative stress. The clinical implications of these physiological adaptations are profound...
April 21, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28422426/dinosaurs-chameleons-humans-and-evo-devo-path-linking-%C3%A3-tienne-geoffroy-s-teratology-waddington-s-homeorhesis-alberch-s-logic-of-monsters-and-goldschmidt-hopeful-monsters
#16
REVIEW
Rui Diogo, Geoffrey Guinard, Raul E Diaz
Since the rise of evo-devo (evolutionary developmental biology) in the 1980s, few authors have attempted to combine the increasing knowledge obtained from the study of model organisms and human medicine with data from comparative anatomy and evolutionary biology in order to investigate the links between development, pathology, and macroevolution. Fortunately, this situation is slowly changing, with a renewed interest in evolutionary developmental pathology (evo-devo-path) in the past decades, as evidenced by the idea to publish this special, and very timely, issue on "Developmental Evolution in Biomedical Research...
May 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/28421720/enantioselective-organocatalytic-synthesis-of-a-secoyohimbane-inspired-compound-collection-with-neuritogenic-activity
#17
Herbert Waldmann, Tim Förster, Sara Lopéz-Tosco, Slava Ziegler, Andrey P Antonchick
Natural products provide evolutionary validated core structures inspiring the synthesis of new compound collections endowed with neurite growth-promoting activity. Rhynchophylline is the major component of Uncaria species which has been used to treat neurological diseases in Chinese traditional medicine. According to the structure of this spirocyclic secoyohimbane alkaloid, we developed a highly enantioselective and efficient organocatalyzed synthesis method to provide the tetracyclic secoyohimbane scaffold incorporating a quaternary and three tertiary stereogenic centers in a one-pot multistep reaction sequence...
April 19, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28412903/phage-life-cycles-behind-bacterial-biodiversity
#18
Tomasz Olszak, Agnieszka Latka, Bartosz Roszniowski, Miguel Angel Valvano, Zuzanna Drulis-Kawa
Bacteriophages (phages or bacterial viruses) are the most abundant biological entities in our planet; their influence reaches far beyond the microorganisms they parasitize. Phages are present in every environment and shape up every bacterial population in both active and passive ways. They participate in the circulation of organic matter and drive the evolution of microorganisms by horizontal gene transfer at unprecedented scales. The mass flow of genetic information in the microbial world influences the biosphere and poses challenges for science and medicine...
April 13, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28411241/2-alkylquinolone-alkaloid-biosynthesis-in-the-medicinal-plant-evodia-rutaecarpa-involves-collaboration-of-two-novel-type-iii-polyketide-synthases
#19
Takashi Matsui, Takeshi Kodama, Takahiro Mori, Tetsuhiro Tadakoshi, Hiroshi Noguchi, Ikuro Abe, Hiroyuki Morita
2-Alkylquinolone (2AQ) alkaloids are pharmaceutically and biologically important natural products produced by both bacteria and plants, with a wide range of biological effects, including antibacterial, cytotoxic, anticholinesterase, and quorum-sensing signaling activities. These diverse activities and 2AQ occurrence in vastly different phyla have raised much interest in the biosynthesis pathways leading to their production. Previous studies in plants have suggested that type III polyketide synthases (PKSs) might be involved in 2AQ biosynthesis, but this hypothesis is untested...
April 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28408460/can-histologic-transformation-of-follicular-lymphoma-be-predicted-and-prevented
#20
Robert Kridel, Laurie H Sehn, Randy D Gascoyne
Transformation to aggressive lymphoma is a critical event in the clinical course of follicular lymphoma patients. Yet, it is a challenge to reliably predict transformation at the time of diagnosis. Understanding the risk of transformation would be useful to guide and monitor patients, as well as for evaluation of novel treatment strategies that could potentially prevent transformation. Herein, we review the contribution of clinical, pathological and genetic risk factors to transformation. Patients with multiple clinical high-risk factors are at elevated risk of transformation but we are currently lacking a prognostic index that would specifically address transformation rather than disease progression or overall survival...
April 13, 2017: Blood
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