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Emile Jeunesse, Patrick O'Malley, Nick Petrus, Chelsea McCoy
Hypothermia is defined as a significant drop in core body temperature below 35°C (95°F). It is traditionally staged as mild, moderate, severe, and profound at temperatures of 35°C to 32°C (95°F to 89.6°F), 32°C to 28°C (89.6°F to 82.4°F), <28°C (<82.4°F), and <24°C (75.2°F), respectively. It can also be classified into the same stages by clinical presentations. We present a patient that fits into two different stages based on core body temperature and clinical presentation...
March 2024: Curēus
#2
Ben Miller, Alexander Crider, Bhooma Aravamuthan, Rafael Galindo
UNLABELLED: The pregnancy hormone, human chorionic gonadotropin (hCG) is an immunoregulatory and neurotrophic glycoprotein of potential clinical utility in the neonate at risk for cerebral injury. Despite its well-known role in its ability to modulate the innate immune response during pregnancy, hCG has not been demonstrated to affect the pro-degenerative actions of inflammation in neonatal hypoxia-ischemia (HI). Here we utilize a neonatal mouse model of mild HI combined with intraperitoneal administration of lipopolysaccharide (LPS) to evaluate the neuroprotective actions of hCG in the setting of endotoxin-mediated systemic inflammation...
March 30, 2024: bioRxiv
#3
REVIEW
Nitisha Beniwal, Anamika Verma, Chandra Lekha Putta, Aravind Kumar Rengan
In 2020, approximately 10 million deaths worldwide were attributed to cancer, making it the primary cause of death globally. Photothermal therapy (PTT) is one of the novel ways to treat and abolish cancer. PTT significantly impacts cancer theranostics compared to other therapies like surgery, chemotherapy, and radiotherapy due to its remarkable binding capability to tumor sites and lower invasiveness into normal healthy tissues. PTT relies on photothermal agents (PTAs), which generate heat by absorbing the near-infrared (NIR) light and destroying cancer cells...
2024: Nanotheranostics
#4
JOURNAL ARTICLE
Xi Zhang, Yaokun Wang, Dandan Yi, Chi Zhang, Binhuan Ning, Yushun Fu, Yanlong Jia, Tianyun Wang, Xiaoyin Wang
Transient gene expression system is an important tool for rapid production of recombinant proteins in Chinese hamster ovary (CHO) cells. However, their low productivity is the main hurdle to overcome. An effective approach through which to obtain high protein yield involves targeting transcriptional, post-transcriptional events (PTEs), and culture conditions. Here, we investigated the effects of protein disulfide isomerase (PDI) and spliced X-box binding protein 1 (XBP-1s) co-overexpression combined with mild hypothermia on the transient yields of recombinant proteins in CHO cells...
February 28, 2024: Bioprocess and Biosystems Engineering
#5
JOURNAL ARTICLE
Xiao-Rui Xi, Zhi-Qiang Zhang, Yan-Li Li, Zheng Liu, Dong-Yang Ma, Zan Gao, Shan Zhang
Mitochondrial transfer occurs between cells, and it is important for damaged cells to receive healthy mitochondria to maintain their normal function and protect against cell death. Accumulating evidence suggests that the functional mitochondria of astrocytes are released and transferred to oxygen-glucose deprivation/reoxygenation (OGD/R)-injured neurons. Mild hypothermia (33 °C) is capable of promoting this process, which partially restores the function of damaged neurons. However, the pathways and mechanisms by which mild hypothermia facilitates mitochondrial transfer remain unclear...
February 23, 2024: Brain Research
#6
JOURNAL ARTICLE
Xiaozheng Zhu, Ruili Guan, Yuankang Zou, Ming Li, Jingyuan Chen, Jianbin Zhang, Wenjing Luo
Cold-inducible RNA binding protein (CIRBP), a stress response protein, protects cells from mild hypothermia or hypoxia by stabilizing specific mRNAs and promoting their translation. Neurons subjected to hypobaric hypoxia insult trigger various cell death programs. One of these is ferroptosis, a novel non-apoptotic form of programmed cell death, which is characterized by excessive iron ion accumulation and lipid peroxidation. Here, we establish that CIRBP can regulate neuronal ferroptosis both in vivo and in vitro...
February 22, 2024: Cell Death and Differentiation
#7
JOURNAL ARTICLE
Parvaneh Sadeghi Moghaddam, Mohammad Aghaali, Seyede Zeinab Modarresy, Samira Shahhamzei, Maryam Aljaboori
OBJECTIVES: Hypoxic-ischemic encephalopathy (HIE) is still a relevant cause of neonatal mortality and morbidity. HIE severity can predict long-term outcomes. Sarnat staging is one of the most common methods used to evaluate HIE severity. However, an ongoing urge exists to find other accurate and affordable ways to accompany this clinical staging for HIE. This study aimed to evaluate the relationship between cerebral arteries' resistive indices and other hypoxic-ischemic encephalopathy indicators using Sarnat scoring of newborns subjected to perinatal asphyxia...
2024: Iranian Journal of Child Neurology
#8
REVIEW
Pasquale Raimondo, Gianmarco Intini, Gianfranco Lauletta, Valentina Teora, Sergio Domenico Lenoci, Giovanni Rubino, Maria Arcangela Villani, Agnese Armenise, Antonia Stripoli, Giuseppe Colantuono, Nicola Di Bari, Giuseppe Fiore, Gianluca Paternoster, Salvatore Grasso
Cardiac surgery with cardiopulmonary bypass (CBP) is essential for different cardiac procedures in order to perform surgery with a clear sight field.To safely perform surgery with CPB and preserve brain, kidney, and patient tissue from ischemic damage, cold cardioplegia, and mild to deep hypothermia are induced during the operation.Cryoglobulinemia is a hematological/infective-related disease (in certain cases idiopathic) in which temperature-dependent antibodies tend to aggregate and form emboli in the vascular system causing tissue damage if exposed to low temperature...
January 25, 2024: J Anesth Analg Crit Care
#9
JOURNAL ARTICLE
Xiaoni Wang, Shulian Chen, Xiaoyu Wang, Zhen Song, Ziqi Wang, Xiaofei Niu, Xiaochu Chen, Xuyi Chen
Controlling intracranial pressure, nerve cell regeneration, and microenvironment regulation are the key issues in reducing mortality and disability in acute brain injury. There is currently a lack of effective treatment methods. Hibernation has the characteristics of low temperature, low metabolism, and hibernation rhythm, as well as protective effects on the nervous, cardiovascular, and motor systems. Artificial hibernation technology is a new technology that can effectively treat acute brain injury by altering the body's metabolism, lowering the body's core temperature, and allowing the body to enter a state similar to hibernation...
September 1, 2024: Neural Regeneration Research
#10
JOURNAL ARTICLE
Zsuzsanna Varga, Csilla Andorka, Margit Pataki, Unoke Meder, Eniko Szakmar, Attila J Szabo, Miklos Szabo, Agnes Jermendy
AIM: Predicting neurodevelopmental outcomes in hypoxic-ischaemic encephalopathy (HIE) remains imprecise, despite advanced imaging and neurophysiological tests. We explored the predictive value of socio-economic status (SES). METHODS: The cohort comprised 93 infants (59% male) with HIE, who had received therapeutic hypothermia. Patients underwent magnetic resonance imaging, and brain injuries were quantified using the Barkovich scoring system. Family SES was self-reported using a questionnaire...
December 18, 2023: Acta Paediatrica
#11
JOURNAL ARTICLE
Mehmet N Cizmeci, Diane Wilson, Maya Singhal, Amr El Shahed, Brian Kalish, Emily Tam, Vann Chau, Linh Ly, Vanna Kazazian, Cecil Hahn, Helen Branson, Steven P Miller
OBJECTIVE: To compare hypoxic-ischemic injury on early cranial ultrasonography (cUS) and post-rewarming brain magnetic resonance imaging (MRI) in newborn infants with hypoxic-ischemic encephalopathy (HIE) and to correlate that neuroimaging with neurodevelopmental outcomes. STUDY DESIGN: This was a retrospective cohort study of infants with mild, moderate, and severe HIE treated with therapeutic hypothermia and evaluated with early cUS and postrewarming MRI. Validated scoring systems were used to compare the severity of brain injury on cUS and MRI...
March 2024: Journal of Pediatrics
#12
JOURNAL ARTICLE
Zachary Aldewereld, Christopher Horvat, Joseph A Carcillo, Gilles Clermont
OBJECTIVE: To investigate whether pediatric sepsis phenotypes are stable in time. METHODS: Retrospective cohort study examining children with suspected sepsis admitted to a PICU at a large free-standing children's hospital during two distinct periods: 2010-2014 (Early Cohort) and 2018-2020 (Late Cohort). K-means consensus clustering was used to derive types separately in the cohorts. Variables included ensured representation of all organ systems. RESULTS: 1,091 subjects were in the Early Cohort and 737 subjects in the Late Cohort...
November 16, 2023: Shock
#13
Khalid Alfares, Hye Jeong Han
Sarcoidosis is an inflammatory condition that can impact multiple organs in the body such as the lungs, skin, eyes, and, occasionally, the central nervous system. When sarcoidosis affects the nervous system, it is referred to as neurosarcoidosis and is estimated to occur in approximately 5%-15% of sarcoid patients. When neurosarcoidosis affects the pituitary gland, it can result in panhypopituitarism, which can be life-threatening. A 35-year-old male with a known diagnosis of sarcoidosis by skin biopsies presented to the hospital with altered mental status, hypernatremia, hypotension, and hypothermia...
August 2023: Curēus
#14
JOURNAL ARTICLE
Jiang Li, Shaonian Tang, Juannli Liu, Wenlin He, Jinjin Yan, Zhiyong Huang, Xuesong Li
INTRODUCTION: The aim of this study was to discuss the safety of rapid administration of 4°C hypothermic normal saline into the occluded vessels using an intra-arterial catheter to induce mild hypothermia following endovascular thrombectomy in patients with acute large vessel occlusion cerebral infarction. METHODS: We selected 78 patients with acute large vessel occlusion cerebral infarction who underwent endovascular thrombectomy in the Department of Neurology of our hospital from January 2020 to July 2022 and achieved TICI 2b recanalization...
August 28, 2023: Journal of Vascular Research
#15
REVIEW
Sarah M Perman, Jason A Bartos, Marina Del Rios, Michael W Donnino, Karen G Hirsch, Jacob C Jentzer, Peter J Kudenchuk, Michael C Kurz, Carolina B Maciel, Venu Menon, Ashish R Panchal, Jon C Rittenberger, Katherine M Berg
Targeted temperature management has been a cornerstone of post-cardiac arrest care for patients remaining unresponsive after return of spontaneous circulation since the initial trials in 2002 found that mild therapeutic hypothermia improves neurological outcome. The suggested temperature range expanded in 2015 in response to a large trial finding that outcomes were not better with treatment at 33° C compared with 36° C. In 2021, another large trial was published in which outcomes with temperature control at 33° C were not better than those of patients treated with a strategy of strict normothermia...
September 19, 2023: Circulation
#16
JOURNAL ARTICLE
Gisela Lilja, Susann Ullén, Josef Dankiewicz, Hans Friberg, Helena Levin, Erik Blennow Nordström, Katarina Heimburg, Janus Christian Jakobsen, Marita Ahlqvist, Frances Bass, Jan Belohlavek, Roy Bjørkholt Olsen, Alain Cariou, Glenn Eastwood, Hans Rune Fanebust, Anders M Grejs, Lisa Grimmer, Naomi E Hammond, Jan Hovdenes, Juraj Hrecko, Manuela Iten, Henriette Johansen, Thomas R Keeble, Hans Kirkegaard, Jean-Baptiste Lascarrou, Christoph Leithner, Mildred Eden Lesona, Anja Levis, Marco Mion, Marion Moseby-Knappe, Leanlove Navarra, Per Nordberg, Paolo Pelosi, Rachael Quayle, Christian Rylander, Helena Sandberg, Manoj Saxena, Claudia Schrag, Michal Siranec, Cassina Tiziano, Philippe Vignon, Pedro David Wendel-Garcia, Matt P Wise, Kim Wright, Niklas Nielsen, Tobias Cronberg
IMPORTANCE: The Targeted Hypothermia vs Targeted Normothermia After Out-of-Hospital Cardiac Arrest (TTM2) trial reported no difference in mortality or poor functional outcome at 6 months after out-of-hospital cardiac arrest (OHCA). This predefined exploratory analysis provides more detailed estimation of brain dysfunction for the comparison of the 2 intervention regimens. OBJECTIVES: To investigate the effects of targeted hypothermia vs targeted normothermia on functional outcome with focus on societal participation and cognitive function in survivors 6 months after OHCA...
October 1, 2023: JAMA Neurology
#17
REVIEW
Caiyun Liu, Haixin Yu, Zhengchao Li, Shulian Chen, Xiaoyin Li, Xuyi Chen, Bo Chen
Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries. At present, no effective clinical treatment exists. As one of the artificial hibernation techniques, mild hypothermia has preliminarily confirmed its clinical effect on spinal cord injury. However, its technical defects and barriers, along with serious clinical side effects, restrict its clinical application for spinal cord injury. Artificial hibernation is a future-oriented disruptive technology for human life support...
January 2024: Neural Regeneration Research
#18
JOURNAL ARTICLE
Hiroki Yago, Jun Homma, Hidekazu Sekine, Yuhei Higashi, Hiroyuki Sakurai, Tatsuya Shimizu
Organ transplantation is a definitive treatment for endocrine disorders, but donor shortages limit the use of this technique. The development of regenerative therapies would revolutionize the treatment of endocrine disorders. As is the case for harvested organs, the ideal bioengineered graft would comprise vascularized endocrine tissue, contain blood vessels that could be anastomosed to host vessels, have stable blood flow, and be suitable for transplantation into various sites. Here, we describe a transplantable endocrine tissue graft that was fabricated by ex vivo perfusion of tricultured cell sheets (islet β-cells, vascular endothelial cells, and mesenchymal stem cells) on a vascularized tissue flap of in vivo origin...
July 24, 2023: Biofabrication
#19
JOURNAL ARTICLE
Suixin Liang, Yunxing Ti, Xiuhong Li, Wenjia Zhou
BACKGROUND: Moderate therapeutic hypothermia is protective against several cellular stressors. However, the mechanisms behind this protection are not entirely known. In the current investigation, we investigated that therapeutic hypothermia at 33°C administered following peroxide-induced oxidative stress might protect human oligodendroglioma cells using an in vitro model. METHODS AND RESULTS: Tert-butyl peroxide treatment for one hour significantly increased cell apoptosis and suppressed cell viability...
2023: Neuropsychiatric Disease and Treatment
#20
JOURNAL ARTICLE
Kullasate Sakpichaisakul, Mohamed El-Dib, Chelsea Munster, Krittin J Supapannachart, Edward Yang, Brain H Walsh, Joseph J Volpe, Terrie E Inder
OBJECTIVE: This study aimed to describe the evolution of amplitude-integrated electroencephalography (aEEG) in neonatal encephalopathy (NE) during therapeutic hypothermia (TH) and evaluate the association between aEEG parameters and magnetic resonance imaging (MRI) injury. STUDY DESIGN: aEEG data of infants who underwent TH were reviewed for background, sleep wake cycling (SWC), and seizures. Conventional electroencephalography (cEEG) background was assessed from the reports...
August 9, 2023: American Journal of Perinatology
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