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https://www.readbyqxmd.com/read/28096677/long-term-bicycle-riding-ameliorates-the-depression-of-the-patients-undergoing-hemodialysis-by-affecting-the-levels-of-interleukin-6-and-interleukin-18
#1
Chunhui Zhao, Hui Ma, Lei Yang, Yong Xiao
PURPOSE: Hemodialysis patients with depression have a higher risk of death and hospitalization. Although there is pharmacological management for the depression of hemodialysis patients, the adverse effect of the drug limits the use. The nonpharmacological way, bicycle riding, may be an effective way for the therapy of the depression in hemodialysis patients. However, the underlying mechanism of this relationship is still not fully explained, while interleukin-6 (IL-6) and interleukin-18 (IL-18) are associated with depression and exercise...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28096442/kinetic-modeling-of-incremental-ambulatory-peritoneal-dialysis-exchanges
#2
Steven Guest, John K Leypoldt, Michelle E Cassin, Martin J Schreiber
♦ Background: Incremental peritoneal dialysis (PD), the gradual introduction of dialysate exchanges at less than full-dose therapy, has been infrequently described in clinical reports. One concern with less than full-dose dialysis is whether urea clearance targets are achievable with an incremental regimen. In this report, we used a large database of PD patients, across all membrane transport types, and performed urea kinetic modeling determinations of possible incremental regimens for an individual membrane type...
January 17, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28095892/comparative-effectiveness-and-cost-effectiveness-of-chuna-manual-therapy-versus-conventional-usual-care-for-nonacute-low-back-pain-study-protocol-for-a-pilot-multicenter-pragmatic-randomized-controlled-trial-pcrn-study
#3
Byung-Cheul Shin, Me-Riong Kim, Jae-Heung Cho, Jae-Young Jung, Koh-Woon Kim, Jun-Hwan Lee, Kibong Nam, Min Ho Lee, Eui-Hyoung Hwang, Kwang-Ho Heo, Namkwen Kim, In-Hyuk Ha
BACKGROUND: While Chuna manual therapy is a Korean manual therapy widely used primarily for low back pain (LBP)-related disorders in Korea, well-designed studies on the comparative effectiveness of Chuna manual therapy are scarce. METHODS/DESIGN: This study is the protocol for a three-armed, multicenter, pragmatic randomized controlled pilot trial. Sixty severe nonacute LBP patients (pain duration of at least 3 weeks, Numeric Rating Scale (NRS) ≥5) will be recruited at four Korean medicine hospitals...
January 17, 2017: Trials
https://www.readbyqxmd.com/read/28093370/a-comparison-of-locomotor-therapy-interventions-partial-body-weight-supported-treadmill-lokomat%C3%A2-and-g-eo%C3%A2-training-in-persons-with-traumatic-brain-injury
#4
Alberto Esquenazi, Stella Lee, Amanda Wikoff, Andrew Packel, Theresa Toczylowski, John Feeley
BACKGROUND: Literature in the application of gait training techniques in persons with traumatic brain injury is limited. Current techniques require of multiple staff and are physically demanding. The use of a robotic locomotor training may provide improved training capacity for this population. OBJECTIVE: To examine the impact of three different modes of locomotor therapy on gait velocity and spatiotemporal symmetry using: an end effector robot (G-EO™); a robotic exoskeleton (Lokomat®) and manual assisted partial-body weight supported treadmill training (PBWSTT) in participants with traumatic brain injury...
January 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28089655/statins-and-primary-prevention-of-venous-thromboembolism-a-systematic-review-and-meta-analysis
#5
Setor K Kunutsor, Samuel Seidu, Kamlesh Khunti
BACKGROUND: Statins have been suggested to have a protective effect on venous thromboembolism (which includes deep vein thrombosis and pulmonary embolism), but the evidence is uncertain. We sought to evaluate the extent to which statins are associated with first venous thromboembolism events. METHODS: We did a systematic review and meta-analysis of observational cohort studies and randomised controlled trials (RCTs). Relevant studies that reported associations between statins and first venous thromboembolism outcomes were identified from MEDLINE, Embase, Web of Science, Cochrane Library, and a manual search of bibliographies for studies published up until July 18, 2016, and from email correspondence with investigators...
January 12, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28089602/particle-swarm-optimizer-for-weighting-factor-selection-in-intensity-modulated-radiation-therapy-optimization-algorithms
#6
Jie Yang, Pengcheng Zhang, Liyuan Zhang, Huazhong Shu, Baosheng Li, Zhiguo Gui
In inverse treatment planning of intensity-modulated radiation therapy (IMRT), the objective function is typically the sum of the weighted sub-scores, where the weights indicate the importance of the sub-scores. To obtain a high-quality treatment plan, the planner manually adjusts the objective weights using a trial-and-error procedure until an acceptable plan is reached. In this work, a new particle swarm optimization (PSO) method which can adjust the weighting factors automatically was investigated to overcome the requirement of manual adjustment, thereby reducing the workload of the human planner and contributing to the development of a fully automated planning process...
January 12, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28089200/limitations-of-the-current-standards-of-care-for-treating-gout-and-crystal-deposition-in-the-primary-care-setting-a-review
#7
Robert T Keenan
PURPOSE: This article outlines several important issues regarding the management of patients with gout. The topics discussed include best practices for gout based on the most current guidelines, opportunities for improving gout management, and current and emerging therapies for gout. METHODS: [PubMed and Google Scholar databases] were search for all articles and trials published before 2016, using the key terms [hyperuricemia, gout, tophi, joint erosion, joint damage, treatment guidelines, American College of Rheumatology (ACR), European League Against Rheumatism (EULAR), flare, comorbidity, epidemiology, adherence, serum uric acid (sUA), monosodium urate (MSU), <6 mg/dL, MSU crystal formation, as well as individual drug names and classes of treatments of interest (allopurinol, febuxostat, colchicine, non-steroidal anti-inflammatories (NSAIDs)]...
January 11, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28080169/family-oriented-support-famos-development-and-feasibility-of-a-psychosocial-intervention-for-families-of-childhood-cancer-survivors
#8
Hanin Salem, Christoffer Johansen, Kjeld Schmiegelow, Jeanette Falck Winther, Peder Skov Wehner, Henrik Hasle, Steen Rosthøj, Anne E Kazak, Pernille E Bidstrup
BACKGROUND: We developed and tested the feasibility of a manualized psychosocial intervention, FAMily-Oriented Support (FAMOS), a home-based psychosocial intervention for families of childhood cancer survivors. The aim of the intervention is to support families in adopting healthy strategies to cope with the psychological consequences of childhood cancer. The intervention is now being evaluated in a nationwide randomized controlled trial (RCT). METHODS AND DESIGN: FAMOS is based on principles of family systems therapy and cognitive behavioral therapy, and is delivered in six sessions at home...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28076642/activity-rest-rhythm-of-depressed-adolescents-undergoing-therapy-case-studies
#9
Maria Eugênia Mesquita, Maria Eliza Finazzi, Bruno Gonçalves, Lee Fu-I, Leandro L Duarte, José Ricardo Lopes, José Alberto Del-Porto, Luiz Menna-Barreto
Introduction: Disorders of circadian rhythms have been reported in studies of both depressed children and of depressed adolescents. The aim of this study was to evaluate whether there is a relationship between the 24-hour spectral power (24h SP) of the activity/rest rhythm and the clinical course of depression in adolescents. Methods: Six 14 to 17-year-old adolescents were recruited for the study. They were all suffering from major depressive disorder, according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria, as identified by the Schedule for Affective Disorders and Schizophrenia for School Aged Children: Present and Lifetime Version (K-SADS-PL)...
October 2016: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28076371/meta-analysis-of-the-long-term-success-rate-of-different-interventions-in-benign-biliary-strictures
#10
Orsolya Huszár, Bálint Kokas, Péter Mátrai, Péter Hegyi, Erika Pétervári, Áron Vincze, Gabriella Pár, Patrícia Sarlós, Judit Bajor, József Czimmer, Dóra Mosztbacher, Katalin Márta, Csaba Zsiborás, Péter Varjú, Ákos Szücs
BACKGROUND: Benign biliary stricture is a rare condition and the majority of the cases are caused by operative trauma or chronic inflammation based on various etiology. Although the initial results of endoscopic, percutaneous and surgical treatment are impressive, no comparison about long term stricture resolution is available. AIMS: The goal of this study was to compare the long term disease free survival in benign biliary strictures with various etiology after surgery, percutaneous transhepatic-and endoscopic treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28075089/autism-spectrum-disorder-primary-care-principles
#11
Kristian E Sanchack, Craig A Thomas
Autism spectrum disorder is characterized by difficulty with social communication and restricted, repetitive patterns of behavior, interest, or activities. The Diagnostic and Statistical Manual of Mental Disorders, 5th ed., created an umbrella diagnosis that includes several previously separate conditions: autistic disorder, Asperger syndrome, childhood disintegrative disorder, and pervasive developmental disorder not otherwise specified. There is insufficient evidence to recommend screening for autism spectrum disorder in children 18 to 30 months of age in whom the disorder is not suspected; however, there is a growing body of evidence that early intensive behavioral intervention based on applied behavior analysis improves cognitive ability, language, and adaptive skills...
December 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/28072831/a-probabilistic-method-for-estimation-of-bowel-wall-thickness-in-mr-colonography
#12
Thomas Hampshire, Alex Menys, Asif Jaffer, Gauraang Bhatnagar, Shonit Punwani, David Atkinson, Steve Halligan, David J Hawkes, Stuart A Taylor
MRI has recently been applied as a tool to quantitatively evaluate the response to therapy in patients with Crohn's disease, and is the preferred choice for repeated imaging. Bowel wall thickness on MRI is an important biomarker of underlying inflammatory activity, being abnormally increased in the acute phase and reducing in response to successful therapy; however, a poor level of interobserver agreement of measured thickness is reported and therefore a system for accurate, robust and reproducible measurements is desirable...
2017: PloS One
https://www.readbyqxmd.com/read/28070986/predicting-severity-of-disease-causing-variants
#13
Abhishek Niroula, Mauno Vihinen
Most diseases, including those of genetic origin, express a continuum of severity. Clinical interventions for numerous diseases are based on the severity of the phenotype. Predicting severity due to genetic variants could facilitate diagnosis and choice of therapy. Although computational predictions have been used as evidence for classifying the disease-relevance of genetic variants, special tools for predicting disease severity in large scale are missing. Here, we manually curated a dataset containing variants leading to severe and less severe phenotypes and studied the abilities of variation impact predictors to distinguish between them...
January 9, 2017: Human Mutation
https://www.readbyqxmd.com/read/28070268/a-systematic-review-of-thrust-manipulation-for-non-surgical-shoulder-conditions
#14
REVIEW
Amy L Minkalis, Robert D Vining, Cynthia R Long, Cheryl Hawk, Katie de Luca
PURPOSE: Although many conservative management options are available for patients with non-surgical shoulder conditions, there is little evidence of their effectiveness. This review investigated one manual therapy approach, thrust manipulation, as a treatment option. METHODS: A systematic search was conducted of the electronic databases from inception to March 2016: PubMed, PEDro, ICL, CINAHL, and AMED. Two independent reviewers conducted the screening process to determine article eligibility...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28068499/metacognitive-interpersonal-therapy-for-personality-disorders-swinging-from-emotional-over-regulation-to-dysregulation-a-case-study
#15
Giampalo Salvatore, Raffaele Popolo, Luisa Buonocore, Anna Maria Ferrigno, Mariagrazia Proto, Anna Sateriale, Marianna Serio, Giancarlo Dimaggio
Many patients with personality disorders (PD) display emotional inhibition or over-regulation (EOR); others display emotional dysregulation (ED)- heightened sensitivity to emotional stimuli with difficulty toning down arousal. To date, most treatments focus on patients with ED, particularly those with borderline disorders, though some focus on EOR. Patients with complex PD often swing from periods of EOR to ED. In this paper, we describe an adaptation of metacognitive interpersonal therapy (MIT), which has been manualized for treating PD with prominent EOR and is aimed at dealing with patients fluctuating from EOR to ED...
December 31, 2016: American Journal of Psychotherapy
https://www.readbyqxmd.com/read/28066520/gait-training-interventions-for-lower-extremity-amputees-a-systematic-literature-review
#16
M Jason Highsmith, Casey R Andrews, Claire Millman, Ashley Fuller, Jason T Kahle, Tyler D Klenow, Katherine L Lewis, Rachel C Bradley, John J Orriola
Lower extremity (LE) amputation patients who use prostheses have gait asymmetries and altered limb loading and movement strategies when ambulating. Subsequent secondary conditions are believed to be associated with gait deviations and lead to long-term complications that impact function and quality of life as a result. The purpose of this study was to systematically review the literature to determine the strength of evidence supporting gait training interventions and to formulate evidence statements to guide practice and research related to therapeutic gait training for lower extremity amputees...
September 2016: Technology and Innovation
https://www.readbyqxmd.com/read/28059651/automatic-estimation-of-extent-of-resection-and-residual-tumor-volume-of-patients-with-glioblastoma
#17
Raphael Meier, Nicole Porz, Urspeter Knecht, Tina Loosli, Philippe Schucht, Jürgen Beck, Johannes Slotboom, Roland Wiest, Mauricio Reyes
OBJECTIVE In the treatment of glioblastoma, residual tumor burden is the only prognostic factor that can be actively influenced by therapy. Therefore, an accurate, reproducible, and objective measurement of residual tumor burden is necessary. This study aimed to evaluate the use of a fully automatic segmentation method-brain tumor image analysis (BraTumIA)-for estimating the extent of resection (EOR) and residual tumor volume (RTV) of contrast-enhancing tumor after surgery. METHODS The imaging data of 19 patients who underwent primary resection of histologically confirmed supratentorial glioblastoma were retrospectively reviewed...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28059093/expression-of-pd-l1-and-presence-of-cd8-positive-t-cells-in-pre-treatment-specimens-of-locally-advanced-cervical-cancer
#18
Emeka K Enwere, Elizabeth N Kornaga, Michelle Dean, Theodora A Koulis, Tien Phan, Maria Kalantarian, Martin Köbel, Prafull Ghatage, Anthony M Magliocco, Susan P Lees-Miller, Corinne M Doll
Several of the cancer immunotherapies under investigation or in clinical use target the programmed death-ligand 1/programmed death-1 (PD-L1/PD-1) signaling axis. PD-L1 expression in tumor samples has been used as a predictive marker for response to these therapeutics, and may also have independent prognostic utility when assessed along with immune cell markers. Our objectives were to assess the expression of PD-L1 in tumor specimens from a uniformly treated patient cohort with locally advanced cervical cancer, and to determine its prognostic significance along with the density of tumor-infiltrating T cells...
January 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28058593/ceftaroline-fosamil-for-community-acquired-pneumonia-and-skin-and-skin-structure-infections-a-systematic-review
#19
Maguy Saffouh El Hajj, Ricky D Turgeon, Kyle John Wilby
Background Ceftaroline is a parentally administered cephalosporin that has an in vitro expanded spectrum of activity compared with other cephalosporins yet data is conflicting regarding its place in therapy. Aim of the Review To compare the efficacy and safety of ceftaroline against standard antibiotic regimens for community-acquired pneumonia (CAP) and complicated skin and skin structure infections (cSSSIs). Method The databases of MEDLINE, EBSCO, and Embase were searched up to June 2016. Manual review of references was completed and experts in the field were contacted for unpublished data...
January 5, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28055124/interventions-for-the-management-of-oral-lichen-planus-a-review-of-the-conventional-and-novel-therapies
#20
REVIEW
Shikha Gupta, Sujoy Ghosh, Sunita Gupta
OBJECTIVE: This narrative review focuses on the rationale & role of conventional and newer therapies in the management of Oral lichen planus with emphasis on randomized controlled trials reported over 2 decades. MATERIALS AND METHODS: Literature search was conducted to identify randomized controlled trials for management of OLP from 1/1/1995 to 31/12/2015; Medline, and Cochrane databases complemented with manual search was used. Primary outcome as resolution of pain was evaluated with analysis of clinical resolution of erythema and ulceration as secondary outcome...
January 5, 2017: Oral Diseases
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