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https://www.readbyqxmd.com/read/28440955/phase-1-dose-escalation-study-of-mirvetuximab-soravtansine-imgn853-a-folate-receptor-%C3%AE-targeting-antibody-drug-conjugate-in-patients-with-solid-tumors
#1
Kathleen N Moore, Hossein Borghaei, David M O'Malley, Woondong Jeong, Shelly M Seward, Todd M Bauer, Raymond P Perez, Ursula A Matulonis, Kelli L Running, Xiaoyan Zhang, Jose F Ponte, Rodrigo Ruiz-Soto, Michael J Birrer
BACKGROUND: Mirvetuximab soravtansine (IMGN853) is an antibody-drug conjugate that selectively targets folate receptor α (FRα). In this phase 1 dose-escalation study, the authors investigated IMGN853 in patients with FRα-positive solid tumors. METHODS: Patients received IMGN853 on day 1 of a 21-day cycle (once every 3 weeks dosing), with cycles repeated until patients experienced dose-limiting toxicity or progression. Dose escalation commenced in single-patient cohorts for the first 4 planned dose levels and then followed a standard 3 + 3 scheme...
April 25, 2017: Cancer
https://www.readbyqxmd.com/read/28440122/effects-of-low-dose-ionizing-radiation-on-dna-damage-caused-pathways-by-reverse-phase-protein-array-and-bayesian-networks
#2
Dong-Chul Kim, Mingon Kang, Ashis Biswas, Chin-Rang Yang, Xiaoyu Wang, Jean X Gao
Ionizing radiation (IR) causing damages to Deoxyribonucleic acid (DNA) constitutes a broad range of base damage and double strand break, and thereby, it induces the operation of relevant signaling pathways such as DNA repair, cell cycle control, and cell apoptosis. The goal of this paper is to study how the exposure to low dose radiation affects the human body by observing the signaling pathway associated with Ataxia Telangiectasia mutated (ATM) using Reverse-Phase Protein Array (RPPA) and isogenic human Ataxia Telangiectasia (A-T) cells under different amounts and durations of IR exposure...
April 2017: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/28437074/many-body-energy-decomposition-with-basis-set-superposition-error-corrections
#3
Istvan Mayer, Imre Bako
The problem of performing many-body decompositions of energy is considered in the case when BSSE corrections are also performed. It is discussed that the two different schemes that have been proposed go back to the two different interpretations of the original Boys-Bernardi counterpoise correction scheme. It is argued that from the physical point of view the ``hierarchical" scheme of Valiron and Mayer should be preferred, and not the scheme recently discussed by Ouyang and Bettens, because it permits the energy of the individual monomers and all the two-body, three-body etc...
April 24, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28437011/noise-reduction-and-functional-maps-image-quality-improvement-in-dynamic-ct-perfusion-using-a-new-k-means-clustering-guided-bilateral-filter-kmgb
#4
Francesco Pisana, Thomas Henzler, Stefan Schönberg, Ernst Klotz, Bernhard Schmidt, Marc Kachelrieß
PURPOSE: Dynamic CT perfusion (CTP) consists in repeated acquisitions of the same volume in different time steps, slightly before, during and slightly afterwards the injection of contrast media. Important functional information can be derived for each voxel, which reflect the local hemodynamic properties and hence the metabolism of the tissue. Different approaches are being investigated to exploit data redundancy and prior knowledge for noise reduction of such datasets, ranging from iterative reconstruction schemes to high dimensional filters...
April 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28437010/technical-note-comparison-of-peripheral-patient-dose-from-mr-guided-60-co-therapy-and-6mv-linear-accelerator-igrt
#5
Pascal Hauri, Roger A Hälg, Uwe Schneider
PURPOSE: The use of X-ray imaging in radiation therapy can give a substantial dose to the patient. A Cobalt machine combined with an magnetic resonance imaging (MRI) was recently introduced to clinical work. One positive aspect of using non-ionizing imaging devices is the reduction of the patient exposure. The purpose of this study was to quantify the difference in out-of-field dose to the patient between the image guided radiation therapy (IGRT) treatment applied with a linear accelerator with cone beam CT (CBCT) equipment and a Cobalt machine combined with an MRI...
April 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28433871/automatic-cumulative-sums-contour-detection-of-fbp-reconstructed-multi-object-nuclear-medicine-images
#6
Nicholas E Protonotarios, George M Spyrou, George A Kastis
The problem of determining the contours of objects in nuclear medicine images has been studied extensively in the past, however most of the analysis has focused on a single object as opposed to multiple objects. The aim of this work is to develop an automated method for determining the contour of multiple objects in positron emission tomography (PET) and single photon emission computed tomography (SPECT) filtered backprojection (FBP) reconstructed images. These contours can be used for computing body edges for attenuation correction in PET and SPECT, as well as for eliminating streak artifacts outside the objects, which could be useful in compressive sensing reconstruction...
April 14, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28432095/mushroom-emergence-detected-by-combining-spore-trapping-with-molecular-techniques
#7
Carles Castaño, Jonàs Oliva, Juan Martínez de Aragón, Josu G Alday, Javier Parladé, Joan Pera, José Antonio Bonet
Obtaining reliable and representative mushroom production data requires time-consuming sampling schemes. In this paper, we assessed a simple methodology to detect mushroom emergence by trapping the fungal spores of the fruiting body community in plots where mushroom production was determined weekly. We compared the performance of filter paper traps with that of funnel traps and combined these spore trapping methods with species-specific quantitative real-time PCR and Illumina MiSeq to determine the spore abundance...
April 21, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28430716/simultaneous-multislice-accelerated-turbo-spin-echo-magnetic-resonance-imaging-comparison-and-combination-with-in-plane-parallel-imaging-acceleration-for-high-resolution-magnetic-resonance-imaging-of-the-knee
#8
Jan Fritz, Benjamin Fritz, Jialu Zhang, Gaurav K Thawait, Dharmdev H Joshi, Li Pan, Dingxin Wang
PURPOSE: We prospectively quantified the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of integrated parallel acquisition technique (PAT) and simultaneous multislice (SMS) acceleration and various combinations thereof, and we further compared two 4-fold-accelerated (PAT2-SMS2) high-resolution turbo spin echo (TSE) magnetic resonance imaging (MRI) protocols of the knee against a clinical 2-fold-accelerated (PAT2-SMS1) TSE standard. MATERIALS AND METHODS: Institutional review board approval was obtained, and all subjects gave informed consent...
April 20, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28430494/quantum-simulation-of-generic-many-body-open-system-dynamics-using-classical-noise
#9
A Chenu, M Beau, J Cao, A Del Campo
We introduce a scheme for the quantum simulation of many-body decoherence based on the unitary evolution of a stochastic Hamiltonian. Modulating the strength of the interactions with stochastic processes, we show that the noise-averaged density matrix simulates an effectively open dynamics governed by k-body Lindblad operators. Markovian dynamics can be accessed with white-noise fluctuations; non-Markovian dynamics requires colored noise. The time scale governing the fidelity decay under many-body decoherence is shown to scale as N^{-2k} with the system size N...
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28430132/celestial-object-imaging-model-and-parameter-optimization-for-an-optical-navigation-sensor-based-on-the-well-capacity-adjusting-scheme
#10
Hao Wang, Jie Jiang, Guangjun Zhang
The simultaneous extraction of optical navigation measurements from a target celestial body and star images is essential for autonomous optical navigation. Generally, a single optical navigation sensor cannot simultaneously image the target celestial body and stars well-exposed because their irradiance difference is generally large. Multi-sensor integration or complex image processing algorithms are commonly utilized to solve the said problem. This study analyzes and demonstrates the feasibility of simultaneously imaging the target celestial body and stars well-exposed within a single exposure through a single field of view (FOV) optical navigation sensor using the well capacity adjusting (WCA) scheme...
April 21, 2017: Sensors
https://www.readbyqxmd.com/read/28430127/image-guided-laparoscopic-surgical-tool-iglast-based-on-the-optical-frequency-domain-imaging-ofdi-to-prevent-bleeding
#11
Byung Jun Park, Seung Rag Lee, Hyun Jin Bang, Byung Yeon Kim, Jeong Hun Park, Dong Guk Kim, Sung Soo Park, Young Jae Won
We present an image-guided laparoscopic surgical tool (IGLaST) to prevent bleeding. By applying optical frequency domain imaging (OFDI) to a specially designed laparoscopic surgical tool, the inside of fatty tissue can be observed before a resection, and the presence and size of blood vessels can be recognized. The optical sensing module on the IGLaST head has a diameter of less than 390 µm and is moved back and forth by a linear servo actuator in the IGLaST body. We proved the feasibility of IGLaST by in vivo imaging inside the fatty tissue of a porcine model...
April 21, 2017: Sensors
https://www.readbyqxmd.com/read/28429061/natural-resource-management-schemes-as-entry-points-for-integrated-landscape-approaches-evidence-from-ghana-and-burkina-faso
#12
Samson Foli, Mirjam A F Ros-Tonen, James Reed, Terry Sunderland
In recognition of the failures of sectoral approaches to overcome global challenges of biodiversity loss, climate change, food insecurity and poverty, scientific discourse on biodiversity conservation and sustainable development is shifting towards integrated landscape governance arrangements. Current landscape initiatives however very much depend on external actors and funding, raising the question of whether, and how, and under what conditions, locally embedded resource management schemes can serve as entry points for the implementation of integrated landscape approaches...
April 20, 2017: Environmental Management
https://www.readbyqxmd.com/read/28425201/numerical-analysis-of-crimping-and-inflation-process-of-balloon-expandable-coronary-stent-using-implicit-solution
#13
Jakub Bukala, Piotr Kwiatkowski, Jerzy Malachowski
The paper presents an applied methodology for numerical Finite Element analysis of coronary stent crimping and the free inflation process with the use of a folded non-compliant angioplasty balloon. The use of an implicit scheme is considered as the most original part of the work, as an explicit finite element procedure is very often preferred. Hitherto, when the implicit solution was used for the Finite Element solution, the simulated issue was largely simplified. Therefore, the authors focused on the modelling methodology with minimum possible simplification, i...
April 20, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28423437/-expert-assessment-of-traumatic-disc-herniations
#14
Martin Schwarze, Marc-André Weber, Florin M Bucur, Marcus Schiltenwolf
In numerous legal areas, expert assessments are needed to clarify the causality of herniated discs: Was the damage caused by an accident? The literature mentions specific requirements regarding the trauma mechanism as well as temporal criteria, which prescribe the causality test. These are essentially high-energy traumas with immediate functional impairments. Accident-related MRI examinations are of paramount importance in the expert assessment process to confirm the primary body harm. In examining the causality constituting liability, competitive causes must be assessed...
April 19, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28422662/use-of-accelerometers-in-the-control-of-practical-prosthetic-arms
#15
Peter Kyberd, Adrian Poulton
Accelerometers can be used to augment the control of powered prosthetic arms. They can detect the orientation of the joint and limb and the controller can correct for the amount of torque required to move the limb. They can also be used to create a platform, with a fixed orientation relative to gravity for the object held in the hand. This paper describes three applications for this technology, in a powered wrist and powered arm. By adding sensors to the arm making these data available to the controller, the input from the user can be made simpler...
April 12, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28422649/visual-servoed-three-dimensional-rotation-control-in-zebrafish-larva-heart-microinjection-system
#16
Songlin Zhuang, Weiyang Lin, Jie Zhong, Gefei Zhang, Li Li, Jianbin Qiu, Huijun Gao
OBJECTIVE: Zebrafish larva heart microinjection is a widely used technique in cardiac disease study. Compared with intensively researched rotation control of spherical or nearly spherical targets with clear structures, such as cells and embryos, 3-D rotation control of zebrafish larva demands new techniques due to its non-transparent structures and irregular outlines. METHODS: In this paper, we present a vision-servo system to automate the rotation process of zebrafish larva body...
April 12, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28422062/cross-layer-design-for-optimizing-transmission-reliability-energy-efficiency-and-lifetime-in-body-sensor-networks
#17
Xi Chen, Yixuan Xu, Anfeng Liu
High transmission reliability, energy efficiency, and long lifetime are pivotal issues for wireless body area networks (WBANs. However, these performance metrics are not independent of each other, making it hard to obtain overall improvements through optimizing one single aspect. Therefore, a Cross Layer Design Optimal (CLDO) scheme is proposed to simultaneously optimize transmission reliability, energy efficiency, and lifetime of WBANs from several layers. Firstly, due to the fact that the transmission power of nodes directly influences the reliability of links, the optimized transmission power of different nodes is deduced, which is able to maximize energy efficiency in theory under the premise that requirements on delay and jitter are fulfilled...
April 19, 2017: Sensors
https://www.readbyqxmd.com/read/28421792/micronutrient-supplementation-in-gastric-bypass-surgery-prospective-study-on-in%C3%AF-ammation-and-iron-metabolism-in-premenopausal-women
#18
Flávia Andréia Marin, Rozangela Verlengia, Alex Harley Crisp, Patrícia Fátima Sousa Novais, Irineu Rasera-Junior, Maria Rita Marques De Oliveira
BACKGROUND: Low-grade chronic inflammation in morbid obesity is associated with impaired iron metabolism. Bariatric surgery is effective in weight loss; however, it can induce specific nutritional deficiencies, such as iron, especially in premenopausal women. Alternatively, after surgery, there is an improvement in systemic inflammation, raising questions concerning the dosages of micronutrient supplementation. OBJECTIVES: This study aimed to assess the effect of two micronutrient supplementation schemes before and 6 months after a Roux-en-Y gastric bypass (RYGB) surgery on inflammation and iron metabolism in premenopausal women...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28415581/tumor-physiological-changes-during-hypofractionated-stereotactic-body-radiation-therapy-assessed-using-multi-parametric-magnetic-resonance-imaging
#19
Heling Zhou, Zhang Zhang, Rebecca Denney, Jessica S Williams, Jeni Gerberich, Strahinja Stojadinovic, Debabrata Saha, John M Shelton, Ralph P Mason
Radiation therapy is a primary treatment for non-resectable lung cancer and hypoxia is thought to influence tumor response. Hypoxia is expected to be particularly relevant to the evolving new radiation treatment scheme of hypofractionated stereotactic body radiation therapy (SBRT). As such, we sought to develop non-invasive tools to assess tumor pathophysiology and response to irradiation. We applied blood oxygen level dependent (BOLD) and tissue oxygen level dependent (TOLD) MRI, together with dynamic contrast enhanced (DCE) MRI to explore the longitudinal effects of SBRT on tumor oxygenation and vascular perfusion using A549 human lung cancer xenografts in a subcutaneous rat model...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415235/general-velocity-pressure-and-initial-condition-for-two-dimensional-and-three-dimensional-lattice-boltzmann-simulations
#20
Omid Reza Mohammadipour, Hamid Niazmand, Sauro Succi
In this paper, an alternative approach to implement initial and boundary conditions in the lattice Boltzmann method is presented. The main idea is to approximate the nonequilibrium component of distribution functions as a third-order power series in the lattice velocities and formulate a procedure to determine boundary node distributions by using fluid variables, consistent with such an expansion. The velocity shift associated with the body force effects is included in this scheme, along with an approximation to determine the mass density in complex geometries...
March 2017: Physical Review. E
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