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Intravesical bladder

Suo Zou, Takahiro Shimizu, Shogo Shimizu, Youichirou Higashi, Kumiko Nakamura, Hideaki Ono, Takaaki Aratake, Motoaki Saito
AIMS: To clarify the roles of hydrogen sulfide (H2 S), an endogenous gasotransmitter, in the rat bladder and prostate, we investigated the distribution of enzymes related to H2 S biosynthesis (cystathionine β-synthase [CBS], cystathionine γ-lyase [CSE], 3-mercaptopyruvate sulfurtransferase [MPST], cysteine aminotransferase [CAT], and D-amino acid oxidase [DAO]) and the content of H2 S. We also investigated the effects of H2 S donors (NaHS and GYY4137) on the contractility of both tissues and on micturition...
August 10, 2018: Neurourology and Urodynamics
Ei-Ichiro Takaoka, Masahiro Kurobe, Hiroki Okada, Shun Takai, Takahisa Suzuki, Nobutaka Shimizu, Joonbeom Kwon, Hiroyuki Nishiyama, Naoki Yoshimura, Christopher J Chermansky
AIMS: To produce an animal model of peripheral neurogenic detrusor underactivity (DU) and to evaluate the effect of TRPV4 receptor activation in this DU model. METHODS: In female Sprague-Dawley rats, bilateral pelvic nerve crush (PNC) was performed by using sharp forceps. After 10 days, awake cystometrograms (CMG) were recorded in sham and PNC rats. A TRPV4 agonist (GSK 1016790A) with or without a TRPV4 antagonist (RN1734) were administered intravesically and CMG parameters were compared before and after drug administration in each group...
August 10, 2018: Neurourology and Urodynamics
Shimpei Sugiura, Noriaki Noto, Mitsuyuki Koizumi, Daiji Takamoto, Naoya Fujikawa, Ichiro Ikeda
We retrospectively evaluated the efficacy of immediate single instillation (SI) of pirarubicine hydrochloride (THP) in the chemoprevention of intermediate and high risk patients with non-muscle-invasive bladder cancer (NMIBC). The study population consisted of 256 intermediate and high risk patients with NMIBC who underwent Bacillus Calmette-Guerin (BCG) induction therapy or delayed intravesical chemotherapy between 1999 and 2014. We introduced SI of 30 mg THP in 30 ml normal saline for all cases in 2010, and thus earlier cases could be considered as historical controls...
July 2018: Hinyokika Kiyo. Acta Urologica Japonica
Mariana G de Oliveira, Daniel M Nascimento, Eduardo C Alexandre, Sandra M Bonilla-Becerra, Adriana Zapparoli, Fabiola Z Mónica, Edson Antunes
AIMS: Overactive bladder (OAB) is one of the most common complications of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM). In healthy conditions, menthol infused intravesically reduces the threshold for initiating micturition reflex, but no study evaluated its effects in diabetic conditions. Therefore, we have used mouse models of T1DM and T2DM to evaluate the effects of menthol on cystometric alterations and increased bladder contractility in vitro. METHODS: For T1DM induction, male C57BL6 mice were injected with streptozotocin (STZ) and evaluated after 4 weeks...
August 8, 2018: Neurourology and Urodynamics
Marie Christine Hupe, Axel S Merseburger, Maike de Wit, Heidrun Rexer, Jürgen E Gschwend, Susanne Krege
BACKGROUND:  In 2016, the first German guideline for bladder cancer was introduced. This survey evaluates current management of bladder cancer in Germany, focusing on systemic therapies and compares this to the guidelines. MATERIAL AND METHODS:  More than 4000 urologists and oncologists in Germany received a questionnaire assessing surgical and systemic therapeutic management of bladder cancer. We received 278 evaluable responses. RESULTS:  This is the largest nationwide survey evaluating current bladder cancer management in Germany...
August 2018: Aktuelle Urologie
Mihai Dorin Vartolomei, Matteo Ferro, Francesco Cantiello, Giuseppe Lucarelli, Savino Di Stasi, Rodolfo Hurle, Giorgio Guazzoni, Gian Maria Busetto, Ettore De Berardinis, Rocco Damiano, Sisto Perdona, Paolo Verze, Roberto La Rocca, Marco Borghesi, Riccardo Schiavina, Eugenio Brunocilla, Gilberto L Almeida, Pierluigi Bove, Estevao Lima, Giovanni Grimaldi, Riccardo Autorino, Nicolae Crisan, Abdal Rahman Abu Farhan, Michele Battaglia, Vincenzo Serretta, Giorgio Ivan Russo, Giuseppe Morgia, Daniela Terracciano, Gennaro Musi, Ottavio de Cobelli, Vincenzo Mirone, Shahrokh F Shariat
INTRODUCTION: The aim of this multicenter study was to investigate the prognostic role of neutrophil-to-lymphocyte ratio (NLR) and to validate the NLR cutoff of 3 in a large multi-institutional cohort of patients with primary T1 HG/G3 non-muscle-invasive bladder cancer (NMIBC). PATIENTS AND METHODS: The study period was from January 2002 through December 2012. A total of 1046 patients with primary T1 HG/G3 who had NMIBC on re-transurethral bladder resection (TURB) who received adjuvant intravesical bacillus Calmette-Guérin therapy with maintenance from 13 academic institutions were included...
July 6, 2018: Clinical Genitourinary Cancer
Athanasios E Dellis, Athanasios G Papatsoris
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a painful and debilitating clinical entity which is challenging to diagnose and even more difficult to treat. Unfortunately, none of the existing oral and intravesical medications have been established as effective and therefore relevant research is ongoing. Areas covered: In this review, the authors present established and emerging treatment options for IC/BPS in terms of medication and minimal invasive procedures. Both American and European Urological Association Guidelines recommend multimodal behavioral techniques alongside oral (e...
August 3, 2018: Expert Opinion on Pharmacotherapy
Asmita Gupte, Anupama Matcha, Michael Lauzardo
BCG has been used as intravesical immunotherapy for the treatment of bladder carcinoma. However, this treatment is not harmless and may lead to complications, with a reported incidence of systemic BCG infection ranging from 3% to 7%. We report a case of culture-proven Mycobacterium bovis (BCG) vertebral osteomyelitis in a 72-year-old patient with bladder carcinoma who was treated with intravesical mitomycin C but did not receive BCG. Cultures from biopsy recovered isolate resembling Mycobacterium tuberculosis biochemically, but resistant to pyrazinamide (PZA)...
July 30, 2018: BMJ Case Reports
Judith Bosschieter, Jakko A Nieuwenhuijzen, André N Vis, Tessa van Ginkel, Birgit I Lissenberg-Witte, Goedele M A Beckers, R Jeroen A van Moorselaar
BACKGROUND: In a recent meta-analysis, subgroups of patients were defined that may not benefit from a single, immediate instillation with chemotherapy. This led to a change in the European Association of Urology bladder cancer guidelines. In a previous paper, our group confirmed the efficacy of an immediate instillation of mitomycin C (MMC). However, prognostic groups in that study differ from those in the meta-analysis. Therefore, we performed a reanalysis using contemporary risk groups...
July 28, 2018: Urologic Oncology
Kazutaka Kida, Yousuke Shimizu, Kosuke Ogawa, Sojun Kanamaru, Noriyuki Ito
Distant metastasis is rare in patients with non-muscle invasive bladder cancer (NMIBC). We describe two cases of NMIBC with distant metastasis diagnosed in the follow-up period after transurethral resection (TUR), with neither intravesical recurrence nor progression to muscle-invasive disease. Case 1 : A 77-yearold man was referred to our hospital for treatment of a bladder tumor with the complaint of asymptomatic gross hematuria. TUR of the bladder tumor was performed. Pathological examination revealed high grade urothelial carcinoma pT1...
June 2018: Hinyokika Kiyo. Acta Urologica Japonica
Tomomi Kuramoto, Toru Nishikawa, Yoshihito Nanpou
Transurethral resection of bladder tumor (TURBT) was performed on the bladder tumor of a 68-yearold male patient. Bacillus Calmette-Guérin (BCG) intravesical therapy was performed to prevent recurrence (Immunobladder : ○R 80 mg once/week×6 times). A 40 mm tumor was noted in the left kidney by renal ultrasound performed two months after the completion of BCGintravesical therapy. Computed tomography (CT) showed non-enhanced multiple mass lesions in the left kidney. Renal tuberculous granuloma, hypovascular renal cell carcinoma or malignant lymphoma was suspected and CT-guided needle biopsy was performed...
May 2018: Hinyokika Kiyo. Acta Urologica Japonica
Nikolai Klebanov, Aravind Raghavan
Intravesical therapy with Bacillus Calmette-Guérin (BCG) is a common and effective therapy for bladder carcinoma in situ. The risks associated with intravesical BCG therapy are significant and rare. Accurate diagnosis and prompt initiation of management significantly reduce the morbidity associated with these risks. Here, we discuss a case of BCG orchitis, a rare but treatable complication of intravesical BCG therapy. We present the case of a 55-year-old Puerto Rican incarcerated male who was diagnosed with high-grade Stage T1 urothelial carcinoma after presenting with hematuria, treated with transurethral resection of bladder tumor (TURBT), mitomycin, and intravesical BCG...
May 29, 2018: Curēus
Marko Babjuk, Maximilian Burger, Eva M Compérat, Paolo Gontero, Hugh A Mostafid, Joan Palou, Bas W G van Rhijn, Morgan Rouprêt, Shahrokh F Shariat, Richard Sylvester, Richard Zigeuner, Otakar Capoun, Daniel Cohen, José L Dominguez-Escrig, Virginia Hernández, Benoit Peyronnet, Thomas Seisen, Viktor Soukup
An early single instillation of intravesical chemotherapy (SICI) used immediately after transurethral resection of the bladder (TURB) can significantly reduce the recurrence rate in selected patients with non-muscle-invasive bladder cancer (NMIBC). SICI should be used in patients with low-risk and with selected intermediate-risk tumours, in particular for multiple primary small papillary tumours, single primary papillary tumours >3cm, and single recurrent papillary tumours recurring >1yr after the previous resection...
July 27, 2018: European Urology Focus
Hui Chen, Jianwen Zeng, Peng Zeng, Chonghe Jiang, Keji Xie, Sivert Lindström
AIMS: The aim of this study was to determine if the duration of the micturition reflex modulation could be prolonged by repeated periods of afferent stimulation in the decorticated rat. METHODS: Eighteen female Sprague-Dawley rats were used for the study, 10 for intravesical electrical stimulation (IVES), and 8 for Ano-genital pudendal afferents stimulation. Repeated constant flow cystometries were performed with body-warm saline (0.06-0.1 mL/min) at about 10 min interval...
July 27, 2018: Neurourology and Urodynamics
Florent Darriet, Paola Bernioles, Ahmed Loukil, Nadia Saidani, Carole Eldin, Michel Drancourt
RATIONALE: To improve the diagnosis of life-threatening Bacilli Calmette Guérin (BCG) arterial aneurysm in patients treated by intravesical instillation of BCG vaccine as adjunctive therapy for non-muscular bladder carcinoma, is a life-threatening condition. Its diagnosis remains cumbersome. PATIENT CONCERNS: One patient with a history of intravesical BCG installation presented with aortic aneurysm with routine microscopic examination after Ziehl-Neelsen staining remaining negative...
July 2018: Medicine (Baltimore)
Ilker Fatih Sahiner, Hakan Soylu, Erhan Ates, Nuray Acar, Ismail Ustunel, Ahmet Danisman
OBJECTIVE: To evaluate the effect of intravesical hyaluronic acid (HA) treatment on inflammatory cells and the severity of inflammation in an interstitial cystitis rat model created with hydrogen chloride (HCL) via immunohistochemical studies and myeloperoxidase activity for the first time in the literature. MATERIALS AND METHODS: A total of 30 adult female white Rattus Norvegicus rats were divided into 3 groups as the HCL group, hyaluronic acid treatment (HCL-HA) group and control group...
April 15, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
F Johannes P van Valenberg, Dalit Strauss-Ayali, Yael Agmon-Gerstein, Astar Friedman, Harm C Arentsen, H Ewout Schaafsma, J Alfred Witjes, Egbert Oosterwijk
Background: We investigated a thermoreversible hydrogel that is highly viscous at body temperature, while fluid-like at a low temperature, thus aiming for a slow and prolonged intravesical drug release. Our study purposed to assess antitumor efficacy of mitomycin C (MMC) mixed with hydrogel in an orthotopic rat bladder cancer model. Methods: Bladders of female Fischer F344 rats were grafted with 1.5 × 106 AY-27 urothelial carcinoma cells. On day 5, tumor presence was assessed by cystoscopy and rats were divided into six groups (five treatment, one control, n = 10/group)...
July 2018: Therapeutic Advances in Urology
Eduardo M Cafarchio, Luciana C Auresco, Luiz A da Silva, Itatiana F Rodart, Barbara do Vale, Janaina S de Souza, Bruno B Antonio, Daniel P Venancio, Gisele Giannocco, Patrik Aronsson, Monica A Sato
Urinary bladder dysfunctions show high prevalence in women. We focused to investigate the intravenous and in situ (topic) vasopressin effects on the bladder and also to characterize the vasopressin receptor subtypes in the bladder. Adult female Wistar rats anesthetized with isoflurane underwent to the cannulation of the femoral artery and vein, and also urinary bladder for mean arterial pressure, heart rate and intravesical pressure (IP) recordings, respectively. Doppler flow probe was placed around the renal artery for blood flow measurement...
July 17, 2018: European Journal of Pharmacology
Jiliang Wen, Shulu Zu, Zhenghao Chen, Stephanie L Daugherty, William C de Groat, Yuqiang Liu, Mingzhen Yuan, Guanghui Cheng, Xiulin Zhang
Literature documents an age related reduction of bladder sensory function. TRPV1 or TRPV4 channels have been implicated in bladder mechano-transduction. To investigate contributions of TRPV1 or TRPV4 to the age related reduction of bladder sensory function, bladder responses to capsaicin (CAP, TRPV1 agonist) and GSK1016790A (GSK, TRPV4 agonist) in retired breeder (RB, 12-15 months) and young adult (2-3 month) female rats were compared using multiple methods. Metabolic cage and continuous infusion cystometry (CMG) recordings revealed that RB rats exhibit larger bladder capacity and lower voiding frequency...
July 18, 2018: American Journal of Physiology. Renal Physiology
Todd Yecies, Shun Li, Yan Zhang, Haotian Cai, Bing Shen, Jicheng Wang, James Roppolo, William de Groat, Changfeng Tai
This study examined the mechanisms underlying pudendal and tibial neuromodulation of bladder function at the single neuron level in the spinal cord. A microelectrode was inserted into the S2 spinal cord of anesthetized cats to record single neuron activity induced by bladder distention over a range of constant intravesical pressures (10-40 cmH2 O). Pudendal nerve stimulation (PNS) or tibial nerve stimulation (TNS) was applied at 5 Hz frequency and 0.2 ms pulse width and at multiples of the threshold (T) intensities for inducing anal or toe twitches...
July 7, 2018: Experimental Neurology
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