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https://www.readbyqxmd.com/read/30061060/near-infrared-fluorescence-imaging-of-matrix-metalloproteinase-2-activity-as-a-biomarker-of-vascular-remodeling-in-hemodialysis-access
#1
Gregory J Nadolski, Stephen J Hunt, Charles N Weber, Mustafa Mohammed, Santiago Pulido, Michael Noji, Ana Chisholm, Terence P F Gade
PURPOSE: To establish the capability of near-infrared fluorescence (NIRF) imaging for the detection of matrix metalloproteinase 2 (MMP-2) activity as a biomarker of vascular remodeling (VR) in arteriovenous fistulae (AVFs) in vivo. MATERIALS AND METHODS: AVFs were created in the right groins of Wistar rats (n = 10), and sham procedures were performed in the contralateral groins. Fistulography via a left common carotid artery approach confirmed stenosis (> 50%) in a subset of animals (n = 5) 4 weeks after AVF creation...
July 27, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/30059129/pulmonary-hypertension-as-seen-in-a-rural-area-in-sub-saharan-africa-high-prevalence-late-clinical-presentation-and-a-high-short-term-mortality-rate-during-follow-up
#2
Anastase Dzudie, Bonaventure Suiru Dzekem, Cabral Tantchou Tchoumi, Leopold Ndemnge Aminde, Ana O Mocumbi, Martin Abanda, Friedrich Thienemann, Andre Pascal Kengne, Karen Sliwa
INTRODUCTION: The epidemiology of pulmonary hypertension (PH) in low- to middle-income countries is poorly characterised. We assessed the prevalence, baseline characteristics and mortality rate in patients with echocardiographically diagnosed PH at a rural cardiac centre in Cameroon. METHODS: We conducted a prospective cohort study in a subsample of 150 participants, aged 18 years and older, diagnosed with PH [defined as right ventricular systolic pressure (RVSP) ≥ 35 mmHg in the absence of pulmonary stenosis and right heart failure]...
July 7, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/30052155/association-between-low-levels-of-serum-mir-638-and-atherosclerotic-plaque-vulnerability-in-patients-with-high-grade-carotid-stenosis
#3
Ana Luque, Abduljalil Farwati, Jerzy Krupinski, Josep M Aran
OBJECTIVE Carotid artery atherosclerosis is a major cause of ischemic stroke. However, reliable criteria to identify patients with high-risk carotid plaques beyond the severity of stenosis are still lacking. Circulating microRNAs (miRNAs) are being postulated as biomarkers for a variety of vascular immune-inflammatory diseases. The authors investigated whether cell-free circulating miR-638, highly expressed in vascular smooth muscle cells and implicated in proliferative vascular diseases, is associated with vulnerable atherosclerotic plaques in high-risk patients with advanced carotid artery stenosis undergoing carotid endarterectomy (CEA)...
July 27, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30048420/prevalence-and-characteristics-of-tracheal-lesions-observed-in-tracheostomized-patients
#4
Fernando Planells, Dario Villalba, Feld Viviana, Valeria Leiva, Mariana Scrigna, Eduardo Distéfano, Jessica Collins, Ana Rocco, Amelia Matesa, Laura Áreas, Nicolas Golfarini, Gregorio Gil-Rossetti, María P Pini, Marcos Hannun, Sabrina Boni, Sabrina Grimaldi, Paula Pedace, Pablo Díaz-Ballvé, Mauro Andreu, Pablo Buñirigo, Diego Noval
BACKGROUND: Our objective was to describe the prevalence and characteristics of tracheal lesions observed in flexile bronchoscopies of tracheostomized patients, and to determine those factors associated with severe injuries. METHODS: This is an analytical, observational, and transversal study. The flexible bronchoscopies of tracheostomized patients from our database were reviewed to assess their lesions. The tracheal lesions were classified according to their severity; lesions obstructing above 50% of the lumen were interpreted as severe and those obstructing <50% as mild...
July 25, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29928182/a-novel-mgp-gene-mutation-causing-keutel-syndrome-in-a-brazilian-patient
#5
Eduardo Perrone, Kelin Chen, Marco Ramos, Maria Fernanda Milanezi, Viviane Nakano, Ariane Falconi, Juliana Silva, Jamille Campos, Celia M C Silva, Joao B O Filho, Ana B A Perez
Keutel syndrome is caused by mutations in the matrix gamma-carboxyglutamic acid ( MGP ) gene (OMIM 154870) and is inherited in an autosomal recessive fashion. It is characterized by brachydactyly, pulmonary artery stenosis, a distinctive facial phenotype, and cartilage calcification. To date, only 36 cases have been reported worldwide. We describe clinical and molecular findings of the first Brazilian patient with Keutel syndrome. Keutel syndrome was suspected based on clinical and morphological evaluation, so we sequenced the MGP gene using the TruSight One Sequencing Panel (Illumina)...
May 2018: Molecular Syndromology
https://www.readbyqxmd.com/read/29914745/tracheal-bronchus-diagnosed-in-children-undergoing-flexible-bronchoscopy
#6
REVIEW
Estela Pérez Ruiz, Pilar Caro Aguilera, Ana Isabel Valdivielso, Sonia Sanchís Cárdenas, Yazmina Martínez García, Javier Pérez Frías
This paper describes the clinical features of paediatric patients with tracheal bronchus (TB) identified with flexible bronchoscopy (FB) in a tertiary care hospital. A retrospective review of every FB with diagnosis of TB carried out in our centre since 1990 was performed which considered specifically: age at diagnosis, gender, semiology, somatic anomalies, tracheal bronchus type, other bronchoscopic findings and clinical progress. Out of 1665 FB in 1337 patients, TB was found in 26 (1.9%). The median age was 15 months (age range 1 month-13 years), with no gender differences...
May 19, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29887898/endotracheal-stent-increased-survival-length-in-patients-with-invasive-thymic-adenocarcinoma
#7
Tatjana Adzic-Vukicevic, Aleksandra Barac, Ana Blanka-Protic, Spasoje Popovic, Zivka Uskokovic-Stefanovic, Jelena Stojsic, Aleksandra Dudvarski Ilic
We reported the first case of inoperative thymic adenocarcinoma successfully palliative treated by the double-stent procedure. In a patient who expressed stridor, computed tomography was done and necrotic mediastinal mass, which protrudes into a trachea, was demonstrated. Fiberoptic bronchoscopy showed tracheal infiltration and 70% stenosis; therefore, surgical resection was inapplicable. Recanalization with repeated argon plasma coagulation and debridement of necrotic mass was performed, followed by placement of the endotracheal stent, radiotherapy, and chemotherapy...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29864559/posterior-reversible-encephalopathy-syndrome-with-status-epilepticus-following-surgery-for-lumbar-stenosis-and-spondylolisthesis
#8
Pedro David Delgado-López, Gloria Garcés-Pérez, Juan García-Carrasco, Esther Alonso-García, Ana Isabel Gómez-Menéndez, Javier Martín-Alonso
BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiologic condition encountered in many different clinical settings; it generally occurs in the context of hypertensive crisis, immunosuppressive therapy, or autoimmune diseases. It is characterized by headache, stupor, seizures, and visual alterations. Magnetic resonance imaging findings include white matter changes preferentially in the parieto-occipital regions. Although pathogenesis is not fully elucidated, vasoconstriction and brain hypoperfusion seem to be the cause of brain ischemia and vasogenic edema...
August 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29797568/excessive-training-induces-molecular-signs-of-pathologic-cardiac-hypertrophy
#9
Alisson L da Rocha, Giovana R Teixeira, Ana P Pinto, Gustavo P de Morais, Luciana da C Oliveira, Larissa Gaioto de Vicente, Lilian E C M da Silva, José R Pauli, Dennys E Cintra, Eduardo R Ropelle, Leandro P de Moura, Rania A Mekary, Ellen C de Freitas, Adelino S R da Silva
Chronic exercise induces cardiac remodeling that promotes left ventricular hypertrophy and cardiac functional improvement, which are mediated by the mammalian or the mechanistic target of rapamycin (mTOR) as well as by the androgen and glucocorticoid receptors (GRs). However, pathological conditions (i.e., chronic heart failure, hypertension, and aortic stenosis, etc.) also induce cardiac hypertrophy, but with detrimental function, high levels of proinflammatory cytokines and myostatin, elevated fibrosis, reduced adenosine monophosphate-activated protein kinase (AMPK) activation, and fetal gene reactivation...
May 24, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29791660/potential-role-of-sorafenib-as-neoadjuvant-therapy-in-unresectable-papillary-thyroid-cancer
#10
Debora L S Danilovic, Gilberto Castro, Felipe S R Roitberg, Felipe A B Vanderlei, Fernanda A Bonani, Ricardo M C Freitas, George B Coura-Filho, Rosalinda Y Camargo, Marco A Kulcsar, Suemi Marui, Ana O Hoff
Total thyroidectomy, radioiodine (RAI) therapy, and TSH suppression are the mainstay treatment for differentiated thyroid carcinomas (DTCs). Treatments for metastatic disease include surgery, external-beam radiotherapy, RAI, and kinase inhibitors for progressive iodine-refractory disease. Unresectable locoregional disease remains a challenge, as standard therapy with RAI becomes unfeasible. We report a case of a young patient who presented with unresectable papillary thyroid carcinoma (PTC), and treatment with sorafenib allowed total thyroidectomy and RAI therapy...
June 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29761155/stenosis-of-hepaticojejunal-anastomosis-with-intrahepatic-lithiasis-treatment-with-single-balloon-enteroscopy-assisted-ercp
#11
Jaime P Rodrigues, Rolando Pinho, Luísa Proença, Joana Silva, Ana Ponte, Mafalda Sousa, João Carlos Silva, João Carvalho
No abstract text is available yet for this article.
April 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29722877/rituximab-for-induction-and-maintenance-therapy-of-granulomatosis-with-polyangiitis-a-single-centre-cohort-study-on-114-patients
#12
Xavier Puéchal, Michele Iudici, Ana Luisa Calich, Alexandre Vivot, Benjamin Terrier, Alexis Régent, Pascal Cohen, Claire Le Jeunne, Luc Mouthon, Philippe Ravaud, Loïc Guillevin
Objectives: To assess efficacy and safety of rituximab (RTX) induction and maintenance therapy for granulomatosis with polyangiitis (GPA) in a single-centre cohort study. Methods: All patients with active GPA, not enrolled in trials, who received ⩾1 RTX infusion(s) for induction were included. At remission, protocolized maintenance RTX infusions were given every 6 months for 18 months. Kaplan-Meier curves were used to estimate survival rates. Univariable analyses identified factors associated with remission failure and relapse, and Cox models retained independent predictors of relapse...
May 2, 2018: Rheumatology
https://www.readbyqxmd.com/read/29701425/analgesia-management-for-mitral-valve-repair-via-minithoracotomy-a-case-report
#13
Andreia Fernandes, Clara Gaio Lima, Nelson Paulo, Catarina Celestino, Ana Fonte Boa, Fátima Lima, Manuela Vieira
INTRODUCTION: Minimally invasive cardiac surgery (MICS), via minithoracotomy, is thought to be a fast track to extubation and recovery after surgery. Chronic pain, due to intercostal nerve injury, develops in up to 50% of postthoracotomy patients.A number of regional anaesthesia and analgesia techniques may be employed, and the anaesthesiologists play a key role in facilitating optimal outcomes after surgery. METHODS: We report a case of postoperative pain management with a local anesthetic infiltration for MICS...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701384/endothelial-function-and-vascular-properties-in-severe-aortic-stenosis-before-and-after-aortic-valve-replacement-surgery
#14
Renata Melo, Francisca A Saraiva, Ana Filipa Ferreira, Soraia Moreira, Raquel Moreira, Rui J Cerqueira, Mário J Amorim, Paulo Pinho, André P Lourenço, Adelino F Leite-Moreira
INTRODUCTION: The degenerative process that results in aortic valve stenosis (AS) has pathophysiological features similar to the atherosclerotic process. We therefore hypothesized that, as in atherosclerosis, endothelial and vascular dysfunction could be a pathophysiologic feature of AS. AIM: To evaluate endothelial function before and after aortic valve replacement (AVR) surgery in patients with severe AS. To correlate endothelial function with severity of AS and clinical profile...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29672304/the-role-of-doppler-ultrassonography-in-significant-and-borderline-stenosis-definition
#15
Ana Castro, Carla Moreira, Paulo Almeida, Norton de Matos, Luís Loureiro, Gabriela Teixeira, Duarte Rego, Sérgio Teixeira, Joaquim Pinheiro, Telmo Carvalho, Isabel Fonseca, José Queirós
BACKGROUND: The definition of significant stenosis (SS) remains controversial. METHODS: We retrospectively reviewed 1,040 consultations. SS was defined in the presence of clinical and echo-Doppler (DDU) criteria: Qa <500 mL/min or Qa decrease >25%; RI >0.7 in the feeding artery or absolute minimal luminal stenosis diameter <2.0 mm. Stenosis without any additional criteria were considered borderline stenosis (BS). RESULTS: Two hundred twenty-one arteriovenous fistulas (AVFs) were included: 58...
2018: Blood Purification
https://www.readbyqxmd.com/read/29662931/ulcerative-colitis-are-we-neglecting-its-progressive-character
#16
Paulo Massinha, Francisco Portela, Sara Campos, Gabriela Duque, Manuela Ferreira, Sofia Mendes, Ana Margarida Ferreira, Carlos Sofia, Luís Tomé
Introduction: Ulcerative colitis (UC) is a chronic disease but its progressive character, with structural damage, is insufficiently studied. Objectives: To analyze a group of patients without referral bias, regarding its clinical course, the morphological damage, and functional status. Methods: We evaluated UC patients diagnosed between January 1, 2000 and December 31, 2004, living in the direct referral area of the hospital and determined the medication use, colectomy rate, structural damage ("lead pipe," stenosis, pseudopolyps, fibrous bridges), and anorectal function (prospective evaluation with the Cleveland Clinic Incontinence Score [CCIS] and the Fecal Incontinence Quality of Life Scale)...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29625885/prognostic-value-of-transthoracic-doppler-echocardiography-coronary-flow-velocity-reserve-in-patients-with-nonculprit-stenosis-of-intermediate-severity-early-after-primary-percutaneous-coronary-intervention
#17
Milorad Tesic, Ana Djordjevic-Dikic, Vojislav Giga, Jelena Stepanovic, Milan Dobric, Ivana Jovanovic, Marija Petrovic, Zlatko Mehmedbegovic, Dejan Milasinovic, Vladimir Dedovic, Milorad Zivkovic, Stefan Juricic, Dejan Orlic, Sinisa Stojkovic, Vladan Vukcevic, Goran Stankovic, Milan Nedeljkovic, Miodrag Ostojic, Branko Beleslin
BACKGROUND: Treatment of nonculprit coronary stenosis during primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction may be beneficial, but the mode and timing of the intervention are still controversial. The aim of this study was to examine the significance and prognostic value of preserved coronary flow velocity reserve (CFVR) in patients with nonculprit intermediate stenosis early after primary percutaneous coronary intervention. METHODS: Two hundred thirty patients with remaining intermediate (50%-70%) stenosis of non-infarct-related arteries, in whom CFVR was performed within 7 days after primary percutaneous coronary intervention, were prospectively enrolled...
April 3, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29617494/transcatheter-aortic-valve-replacement-the-experience-of-one-brazilian-health-care-center
#18
Fabiula Schwartz Azevedo, Marcelo Goulart Correa, Débora Holanda Gonçalves Paula, Alex Dos Santos Felix, Luciano Herman Juaçaba Belém, Ana Paula Chedid Mendes, Valeria Gonçalves Silva, Bruno Miranda Marques, Andrey José de Oliveira Monteiro, Clara Weksler, Alexandre Siciliano Colafranceschi, Daniel Arthur Barata Kasal
OBJECTIVE: Transcatheter aortic valve replacement has been an alternative to invasive treatment for symptomatic severe aortic stenosis in high risk patients. The primary endpoint was 30-day and 1-year mortality from any cause. Secondary endpoints were to compare the clinical and echocardiographic variation pre-and post- transcatheter aortic valve replacement, and the occurrence of complications throughout a 4-year follow-up period. METHODS: This prospective cohort, nestled to a multicenter study (Registro Brasileiro de Implante de Bioprótese por Cateter), describes the experience of a public tertiary center in transcatheter aortic valve replacement...
January 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29595723/inner-scar-umbilicus-new-horizons-for-vertical-abdominoplasty
#19
Flavio H Mendes, Fausto Viterbo, Ana L A P Luna
BACKGROUND: It is reasonable that deflated tissue in massive weight loss patients may demand not only lifting but also some extent of central body tightening, by the fleur-de-lis procedure. Although achieving nice contouring results, poor visible scars, including umbilical complications, have restricted the indications for the anterior vertical approach. The purpose of this article is to present the authors' experience with the inner scar umbilical reconstruction, reflecting overall results in vertical abdominoplasties...
April 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29556149/mechanical-mitral-valve-replacement-during-the-2nd-trimester-of-pregnancy
#20
Anas Boulemden, Gemma L Malin, Suzanne V F Wallace, Amr Mahmoud, William H T Smith, Adam A Szafranek
We report the case of a 44-year-old pregnant woman who was diagnosed with symptomatic severe mitral stenosis that did not respond to optimal medical therapy and balloon valvuloplasty. After a multidisciplinary team discussion on the timing and risks of interventions and postoperative optimization of peripartum anticoagulation, the patient underwent mechanical mitral valve replacement during the 2nd trimester of pregnancy. The outcome was excellent for the mother and the infant. This case emphasizes the importance of a multidisciplinary approach in managing unusual cases...
February 2018: Texas Heart Institute Journal
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