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https://www.readbyqxmd.com/read/30325608/safety-and-effectiveness-evaluation-of-open-reanastomosis-for-obliterative-or-recalcitrant-anastomotic-stricture-after-radical-retropubic-prostatectomy
#1
Carlos Roberto Giúdice, Patricio Esteban Lodi, Ana Milena Olivares, Ignacio Pablo Tobia, Gabriel Andrés Favre
PURPOSE: To evaluate safety, efficacy and functional outcomes after open vesicourethral re - anastomosis using different approaches based on previous urinary continence. MATERIALS AND METHODS: Retrospective study of patients treated from 2002 to 2017 due to vesicourethral anastomosis stricture (VUAS) post radical prostatectomy (RP) who failed endoscopic treatment with at least 3 months of follow-up. Continent and incontinent patients post RP were assigned to abdominal (AA) or perineal approach (PA), respectively...
September 20, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/30296943/usefulness-of-carotid-ultrasonography-in-the-diagnosis-of-coronary-artery-disease-in-patients-undergoing-exercise-echocardiography
#2
Raúl Franco-Gutiérrez, Alberto José Pérez-Pérez, Virginia Franco-Gutiérrez, Ana María Testa-Fernández, Rafael Carlos Vidal-Pérez, Manuel Lorenzo López-Reboiro, Víctor Manuel Puebla-Rojo, Melisa Santás-Álvarez, María Generosa Crespo-Leiro, Carlos González-Juanatey
BACKGROUND: Relationship between carotid and coronary artery disease (CAD) in patients undergoing invasive and non-invasive test is unclear. The aim of the study is to evaluate whether carotid disease is associated with CAD in patients submitted to exercise echocardiography (EE) and if it improves the EE ability to predict CAD. METHODS: We retrospectively studied 156 subjects without previous vascular disease who underwent EE, carotid ultrasonography and coronary angiography between 2002 and 2013...
October 9, 2018: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/30292277/myocardial-t1-and-t2-mapping-in-severe-aortic-stenosis-potential-novel-insights-into-the-pathophysiology-of-myocardial-remodelling
#3
Ana Fehrmann, Melanie Treutlein, Tanja Rudolph, Volker Rudolph, Kilian Weiss, Daniel Giese, Alexander C Bunck, David Maintz, Bettina Baeßler
PURPOSE: Severe aortic stenosis (AS) is known to be associated with substantial myocardial remodelling, leading to diffuse myocardial fibrosis (DMF). Native myocardial T1 is emerging as a novel imaging biomarker for the non-invasive assessment of DMF. In contrast, no studies exist elucidating changes of myocardial T2 reflecting myocardial oedema in the presence of AS. The purpose of the present study was to combine native T1 and T2 mapping in order to characterize myocardial tissue changes in the setting of severe AS...
October 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/30280478/angiographic-characteristics-and-long-term-prognostic-impact-of-coronary-artery-disease-in-survivors-after-sudden-cardiac-arrest-with-a-non-diagnostic-electrocardiogram
#4
María Teresa Nogales-Romo, Carlos Ferrera, Pablo Salinas, Pedro Martínez-Losas, Luis Nombela-Franco, Iván Javier Núñez-Gil, Francisco Javier Noriega, María Del Trigo, Nieves Gonzalo, Pilar Jiménez-Quevedo, Javier Escaned, Antonio Fernández-Ortiz, Carlos Macaya, Ana Viana-Tejedor
OBJECTIVES: Our purpose was to describe the prevalence, distribution, extension, and prognostic value of coronary artery disease (CAD) in patients resuscitated from sudden cardiac arrest (SCA) with non-diagnostic electrocardiogram (ECG). BACKGROUND: The impact of CAD and the indication for cardiac catheterization (CC) in patients resuscitated from SCA with non-diagnostic ECG are uncertain. METHODS: We included prospectively and consecutively 545 patients resuscitated from SCA with at least one CC during hospitalization...
October 2, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/30219874/myeloperoxidase-is-a-potential-molecular-imaging-and-therapeutic-target-for-the-identification-and-stabilization-of-high-risk-atherosclerotic-plaque
#5
Imran Rashid, Ghassan J Maghzal, Yung-Chih Chen, David Cheng, Jihan Talib, Darren Newington, Minqin Ren, Saumitra K Vajandar, Amy Searle, Ana Maluenda, Eva-Lotte Lindstedt, Andrew Jabbour, Antony J Kettle, Andre Bongers, Carl Power, Erik Michaëlsson, Karlheinz Peter, Roland Stocker
Aims: As the inflammatory enzyme myeloperoxidase (MPO) is abundant in ruptured human atherosclerotic plaques, we aimed to investigate the role of MPO as a potential diagnostic and therapeutic target for high-risk plaque. Methods and results: We employed the tandem stenosis model of atherosclerotic plaque instability in apolipoprotein E gene knockout (Apoe-/-) mice. To test the role of MPO, we used Mpo-/-Apoe-/- mice and the 2-thioxanthine MPO inhibitor AZM198. In vivo MPO activity was assessed by liquid chromatography-tandem mass spectrometry detection of 2-chloroethidium generation from hydroethidine and by bis-5HT-DTPA-Gd (MPO-Gd) molecular magnetic resonance imaging (MRI), while plaque phenotype was verified histologically...
September 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30113311/the-role-of-acquisition-and-quantification-methods-in-myocardial-blood-flow-estimability-for-myocardial-perfusion-imaging-ct
#6
Brendan L Eck, Raymond F Muzic, Jacob Levi, Hao Wu, Rachid Fahmi, Yuemeng Li, Anas Fares, Mani Vembar, Amar Dhanantwari, Hiram G Bezerra, David L Wilson
In this work, we clarified the role of acquisition parameters and quantification methods in myocardial blood flow (MBF) estimability for myocardial perfusion imaging using CT (MPI-CT). We used a physiologic model with a CT simulator to generate time-attenuation curves across a range of imaging conditions, i.e. tube current-time product, imaging duration, and temporal sampling, and physiologic conditions, i.e. MBF and arterial input function width. We assessed MBF estimability by precision (interquartile range of MBF estimates) and bias (difference between median MBF estimate and reference MBF) for multiple quantification methods...
September 13, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/30061060/near-infrared-fluorescence-imaging-of-matrix-metalloproteinase-2-activity-as-a-biomarker-of-vascular-remodeling-in-hemodialysis-access
#7
Gregory J Nadolski, Stephen J Hunt, Charles N Weber, Mustafa Mohammed, Santiago Pulido, Michael Noji, Ana Chisholm, Terence P F Gade
PURPOSE: To establish the capability of near-infrared fluorescence (NIRF) imaging for the detection of matrix metalloproteinase 2 (MMP-2) activity as a biomarker of vascular remodeling (VR) in arteriovenous fistulae (AVFs) in vivo. MATERIALS AND METHODS: AVFs were created in the right groins of Wistar rats (n = 10), and sham procedures were performed in the contralateral groins. Fistulography via a left common carotid artery approach confirmed stenosis (> 50%) in a subset of animals (n = 5) 4 weeks after AVF creation...
September 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/30059129/pulmonary-hypertension-as-seen-in-a-rural-area-in-sub-saharan-africa-high-prevalence-late-clinical-presentation-and-a-high-short-term-mortality-rate-during-follow-up
#8
Anastase Dzudie, Bonaventure Suiru Dzekem, Cabral Tantchou Tchoumi, Leopold Ndemnge Aminde, Ana O Mocumbi, Martin Abanda, Friedrich Thienemann, Andre Pascal Kengne, Karen Sliwa
INTRODUCTION: The epidemiology of pulmonary hypertension (PH) in low- to middle-income countries is poorly characterised. We assessed the prevalence, baseline characteristics and mortality rate in patients with echocardiographically diagnosed PH at a rural cardiac centre in Cameroon. METHODS: We conducted a prospective cohort study in a subsample of 150 participants, aged 18 years and older, diagnosed with PH [defined as right ventricular systolic pressure (RVSP) ≥ 35 mmHg in the absence of pulmonary stenosis and right heart failure]...
July 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/30052155/association-between-low-levels-of-serum-mir-638-and-atherosclerotic-plaque-vulnerability-in-patients-with-high-grade-carotid-stenosis
#9
Ana Luque, Abduljalil Farwati, Jerzy Krupinski, Josep M Aran
OBJECTIVE Carotid artery atherosclerosis is a major cause of ischemic stroke. However, reliable criteria to identify patients with high-risk carotid plaques beyond the severity of stenosis are still lacking. Circulating microRNAs (miRNAs) are being postulated as biomarkers for a variety of vascular immune-inflammatory diseases. The authors investigated whether cell-free circulating miR-638, highly expressed in vascular smooth muscle cells and implicated in proliferative vascular diseases, is associated with vulnerable atherosclerotic plaques in high-risk patients with advanced carotid artery stenosis undergoing carotid endarterectomy (CEA)...
July 27, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30048420/prevalence-and-characteristics-of-tracheal-lesions-observed-in-tracheostomized-patients
#10
Fernando Planells, Dario Villalba, Feld Viviana, Valeria Leiva, Mariana Scrigna, Eduardo Distéfano, Jessica Collins, Ana Rocco, Amelia Matesa, Laura Áreas, Nicolas Golfarini, Gregorio Gil-Rossetti, María P Pini, Marcos Hannun, Sabrina Boni, Sabrina Grimaldi, Paula Pedace, Pablo Díaz-Ballvé, Mauro Andreu, Pablo Buñirigo, Diego Noval
BACKGROUND: Our objective was to describe the prevalence and characteristics of tracheal lesions observed in flexile bronchoscopies of tracheostomized patients, and to determine those factors associated with severe injuries. METHODS: This is an analytical, observational, and transversal study. The flexible bronchoscopies of tracheostomized patients from our database were reviewed to assess their lesions. The tracheal lesions were classified according to their severity; lesions obstructing above 50% of the lumen were interpreted as severe and those obstructing <50% as mild...
July 25, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29928182/a-novel-mgp-gene-mutation-causing-keutel-syndrome-in-a-brazilian-patient
#11
Eduardo Perrone, Kelin Chen, Marco Ramos, Maria Fernanda Milanezi, Viviane Nakano, Ariane Falconi, Juliana Silva, Jamille Campos, Celia M C Silva, Joao B O Filho, Ana B A Perez
Keutel syndrome is caused by mutations in the matrix gamma-carboxyglutamic acid ( MGP ) gene (OMIM 154870) and is inherited in an autosomal recessive fashion. It is characterized by brachydactyly, pulmonary artery stenosis, a distinctive facial phenotype, and cartilage calcification. To date, only 36 cases have been reported worldwide. We describe clinical and molecular findings of the first Brazilian patient with Keutel syndrome. Keutel syndrome was suspected based on clinical and morphological evaluation, so we sequenced the MGP gene using the TruSight One Sequencing Panel (Illumina)...
May 2018: Molecular Syndromology
https://www.readbyqxmd.com/read/29914745/tracheal-bronchus-diagnosed-in-children-undergoing-flexible-bronchoscopy
#12
REVIEW
Estela Pérez Ruiz, Pilar Caro Aguilera, Ana Isabel Valdivielso, Sonia Sanchís Cárdenas, Yazmina Martínez García, Javier Pérez Frías
This paper describes the clinical features of paediatric patients with tracheal bronchus (TB) identified with flexible bronchoscopy (FB) in a tertiary care hospital. A retrospective review of every FB with diagnosis of TB carried out in our centre since 1990 was performed which considered specifically: age at diagnosis, gender, semiology, somatic anomalies, tracheal bronchus type, other bronchoscopic findings and clinical progress. Out of 1665 FB in 1337 patients, TB was found in 26 (1.9%). The median age was 15 months (age range 1 month-13 years), with no gender differences...
May 19, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29887898/endotracheal-stent-increased-survival-length-in-patients-with-invasive-thymic-adenocarcinoma
#13
Tatjana Adzic-Vukicevic, Aleksandra Barac, Ana Blanka-Protic, Spasoje Popovic, Zivka Uskokovic-Stefanovic, Jelena Stojsic, Aleksandra Dudvarski Ilic
We reported the first case of inoperative thymic adenocarcinoma successfully palliative treated by the double-stent procedure. In a patient who expressed stridor, computed tomography was done and necrotic mediastinal mass, which protrudes into a trachea, was demonstrated. Fiberoptic bronchoscopy showed tracheal infiltration and 70% stenosis; therefore, surgical resection was inapplicable. Recanalization with repeated argon plasma coagulation and debridement of necrotic mass was performed, followed by placement of the endotracheal stent, radiotherapy, and chemotherapy...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29864559/posterior-reversible-encephalopathy-syndrome-with-status-epilepticus-following-surgery-for-lumbar-stenosis-and-spondylolisthesis
#14
Pedro David Delgado-López, Gloria Garcés-Pérez, Juan García-Carrasco, Esther Alonso-García, Ana Isabel Gómez-Menéndez, Javier Martín-Alonso
BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiologic condition encountered in many different clinical settings; it generally occurs in the context of hypertensive crisis, immunosuppressive therapy, or autoimmune diseases. It is characterized by headache, stupor, seizures, and visual alterations. Magnetic resonance imaging findings include white matter changes preferentially in the parieto-occipital regions. Although pathogenesis is not fully elucidated, vasoconstriction and brain hypoperfusion seem to be the cause of brain ischemia and vasogenic edema...
August 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29797568/excessive-training-induces-molecular-signs-of-pathologic-cardiac-hypertrophy
#15
Alisson L da Rocha, Giovana R Teixeira, Ana P Pinto, Gustavo P de Morais, Luciana da C Oliveira, Larissa Gaioto de Vicente, Lilian E C M da Silva, José R Pauli, Dennys E Cintra, Eduardo R Ropelle, Leandro P de Moura, Rania A Mekary, Ellen C de Freitas, Adelino S R da Silva
Chronic exercise induces cardiac remodeling that promotes left ventricular hypertrophy and cardiac functional improvement, which are mediated by the mammalian or the mechanistic target of rapamycin (mTOR) as well as by the androgen and glucocorticoid receptors (GRs). However, pathological conditions (i.e., chronic heart failure, hypertension, and aortic stenosis, etc.) also induce cardiac hypertrophy, but with detrimental function, high levels of proinflammatory cytokines and myostatin, elevated fibrosis, reduced adenosine monophosphate-activated protein kinase (AMPK) activation, and fetal gene reactivation...
November 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29791660/potential-role-of-sorafenib-as-neoadjuvant-therapy-in-unresectable-papillary-thyroid-cancer
#16
Debora L S Danilovic, Gilberto Castro, Felipe S R Roitberg, Felipe A B Vanderlei, Fernanda A Bonani, Ricardo M C Freitas, George B Coura-Filho, Rosalinda Y Camargo, Marco A Kulcsar, Suemi Marui, Ana O Hoff
Total thyroidectomy, radioiodine (RAI) therapy, and TSH suppression are the mainstay treatment for differentiated thyroid carcinomas (DTCs). Treatments for metastatic disease include surgery, external-beam radiotherapy, RAI, and kinase inhibitors for progressive iodine-refractory disease. Unresectable locoregional disease remains a challenge, as standard therapy with RAI becomes unfeasible. We report a case of a young patient who presented with unresectable papillary thyroid carcinoma (PTC), and treatment with sorafenib allowed total thyroidectomy and RAI therapy...
June 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29761155/stenosis-of-hepaticojejunal-anastomosis-with-intrahepatic-lithiasis-treatment-with-single-balloon-enteroscopy-assisted-ercp
#17
Jaime P Rodrigues, Rolando Pinho, Luísa Proença, Joana Silva, Ana Ponte, Mafalda Sousa, João Carlos Silva, João Carvalho
No abstract text is available yet for this article.
April 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29722877/rituximab-for-induction-and-maintenance-therapy-of-granulomatosis-with-polyangiitis-a-single-centre-cohort-study-on-114-patients
#18
Xavier Puéchal, Michele Iudici, Ana Luisa Calich, Alexandre Vivot, Benjamin Terrier, Alexis Régent, Pascal Cohen, Claire Le Jeunne, Luc Mouthon, Philippe Ravaud, Loïc Guillevin
Objectives: To assess efficacy and safety of rituximab (RTX) induction and maintenance therapy for granulomatosis with polyangiitis (GPA) in a single-centre cohort study. Methods: All patients with active GPA, not enrolled in trials, who received ⩾1 RTX infusion(s) for induction were included. At remission, protocolized maintenance RTX infusions were given every 6 months for 18 months. Kaplan-Meier curves were used to estimate survival rates. Univariable analyses identified factors associated with remission failure and relapse, and Cox models retained independent predictors of relapse...
May 2, 2018: Rheumatology
https://www.readbyqxmd.com/read/29701425/analgesia-management-for-mitral-valve-repair-via-minithoracotomy-a-case-report
#19
Andreia Fernandes, Clara Gaio Lima, Nelson Paulo, Catarina Celestino, Ana Fonte Boa, Fátima Lima, Manuela Vieira
INTRODUCTION: Minimally invasive cardiac surgery (MICS), via minithoracotomy, is thought to be a fast track to extubation and recovery after surgery. Chronic pain, due to intercostal nerve injury, develops in up to 50% of postthoracotomy patients.A number of regional anaesthesia and analgesia techniques may be employed, and the anaesthesiologists play a key role in facilitating optimal outcomes after surgery. METHODS: We report a case of postoperative pain management with a local anesthetic infiltration for MICS...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701384/endothelial-function-and-vascular-properties-in-severe-aortic-stenosis-before-and-after-aortic-valve-replacement-surgery
#20
Renata Melo, Francisca A Saraiva, Ana Filipa Ferreira, Soraia Moreira, Raquel Moreira, Rui J Cerqueira, Mário J Amorim, Paulo Pinho, André P Lourenço, Adelino F Leite-Moreira
INTRODUCTION: The degenerative process that results in aortic valve stenosis (AS) has pathophysiological features similar to the atherosclerotic process. We therefore hypothesized that, as in atherosclerosis, endothelial and vascular dysfunction could be a pathophysiologic feature of AS. AIM: To evaluate endothelial function before and after aortic valve replacement (AVR) surgery in patients with severe AS. To correlate endothelial function with severity of AS and clinical profile...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
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