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https://www.readbyqxmd.com/read/30553764/the-effect-of-1-3-butanediol-and-carbohydrate-supplementation-on-running-performance
#1
Benjamin E Scott, Paul B Laursen, Lewis J James, Benjamin Boxer, Zoe Chandler, Elliot Lam, Tom Gascoyne, Jack Messenger, Stephen A Mears
OBJECTIVES: Ingested ketogenic agents offer the potential to enhance endurance performance via the provision of an alternative exogenous, metabolically efficient, glycogen-sparing fuel (i.e. ketone bodies). This study aimed to assess the impact of combined carbohydrate and 1,3-butanediol (CHO-BD) supplementation on endurance performance, blood beta-hydroxybutyrate (βHB) concentration and glycolytic activity, in comparison to carbohydrate supplementation alone (CHO). DESIGN: Eleven male runners (age 38±12years, mass 67...
December 6, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/30552292/empagliflozin-an-sglt2-inhibitor-reduced-the-mortality-rate-after-acute-myocardial-infarction-with-modification-of-cardiac-metabolomes-and-anti-oxidants-in-diabetic-rats
#2
Hiroto Oshima, Takayuki Miki, Atsushi Kuno, Masashi Mizuno, Tatsuya Sato, Masaya Tanno, Toshiyuki Yano, Kei Nakata, Yukishige Kimura, Koki Abe, Wataru Ohwada, Tetsuji Miura
BACKGROUND: Mechanism by which sodium glucose cotransporter 2 (SGLT2) inhibitors reduce cardiac events in diabetic patients remains unclear. Here we examined effects of an SGLT2 inhibitor on the acute survival rate after myocardial infarction (MI) in an animal model of type 2 diabetes mellitus (DM) and possible involvement of modification of cardiac metabolomes and anti-oxidative proteins. METHODS AND RESULTS: MI was induced in DM rats (OLETF) and control rats (LETO)...
December 14, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/30536560/cardiac-metabolic-modulation-upon-low-carbohydrate-low-protein-ketogenic-diet-in-diabetic-rats-studied-in-vivo-using-hyperpolarized-13-c-pyruvate-butyrate-and-acetoacetate-probes
#3
Desiree Abdurrachim, Xing Qi Teo, Chern Chiuh Woo, Sing Yee Ong, Nurul Farhana Salleh, Janise Lalic, Ru San Tan, Philip Teck Hock Lee
AIMS: To investigate the effects of long-term low-carbohydrate low-protein ketogenic diet (KD) on cardiac metabolism and diabetic cardiomyopathy status in lean diabetic Goto-Kakizaki (GK) rats. MATERIALS AND METHODS: Diabetic GK rats were fed with KD for 62 weeks. Cardiac function and metabolism were assessed using magnetic resonance imaging and 13 C magnetic resonance spectroscopy (13 C-MRS), at rest and under dobutamine stress. 13 C-MRS was performed following injection of hyperpolarized [3-13 C]acetoacetate, [1-13 C]butyrate, or [1-13 C]pyruvate to assess ketone body, short-chain fatty acid, or glucose utilization, respectively...
December 11, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30530230/raspberry-ketone-and-garcinia-cambogia-rebalanced-disrupted-insulin-resistance-and-leptin-signaling-in-rats-fed-high-fat-fructose-diet
#4
Reem T Attia, Yousra Abdel-Mottaleb, Dalaal M Abdallah, Hanan S El-Abhar, Nabila N El-Maraghy
AIM: Obesity is a continually growing pandemic leading to many diseases that affect the overall quality of life. The widely marketed Garcinia cambogia (GC) and Raspberry ketone (RK) were used in this study. Despite their known dietetic effect, however, the metabolomic/signaling pathways involved in this effect are not fully elucidated. Hence, our study comprehends the possible trajectories of their combination against obesity and insulin resistance in addition to exploring their combination merit...
December 6, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30529690/alcohol-induced-ketonemia-is-associated-with-lowering-of-blood-glucose-downregulation-of-gluconeogenic-genes-and-depletion-of-hepatic-glycogen-in-type-2-diabetic-db-db-mice
#5
Mukund P Srinivasan, Noha M Shawky, Bhupendra S Kaphalia, Muthusamy Thangaraju, Lakshman Segar
Alcoholic ketoacidosis and diabetic ketoacidosis are life-threatening complications that share the characteristic features of high anion gap metabolic acidosis. Ketoacidosis is attributed in part to the massive release of ketone bodies (e.g., β-hydroxybutyrate; βOHB) from the liver into the systemic circulation. To date, the impact of ethanol consumption on systemic ketone concentration, glycemic control, and hepatic gluconeogenesis and glycogenesis remains largely unknown, especially in the context of type 2 diabetes...
December 7, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/30525347/metabolomic-consequences-of-genetic-inhibition-of-pcsk9-compared-with-statin-treatment
#6
Eeva Sliz, Johannes Kettunen, Michael Holmes, Clare Williams, Charles Boachie, Qin Wang, Minna Männikkö, Sylvain Sebert, Robin Walters, Kuang Lin, Lona Millwood, Robert Clarke, Liming Li, N Rankin, Paul Welsh, Christian Delles, J Jukema, Stella Trompet, Ian Ford, Markus Perola, Veikko Salomaa, Marjo-Riitta Järvelin, Zhengming Chen, Debbie Lawlor, Mika Ala-Korpela, John Danesh, George Smith, Naveed Sattar, Adam Butterworth, Peter Würtz
BACKGROUND: Both statins and proprotein convertase subtilisin/ kexin type 9 (PCSK9) inhibitors lower blood low-density lipoprotein cholesterol levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects of these 2 lipid-lowering therapies, we performed detailed lipid and metabolite profiling of a large randomized statin trial and compared the results with the effects of genetic inhibition of PCSK9, acting as a naturally occurring trial. METHODS: Two hundred twenty-eight circulating metabolic measures were quantified by nuclear magnetic resonance spectroscopy, including lipoprotein subclass concentrations and their lipid composition, fatty acids, and amino acids, for 5359 individuals (2659 on treatment) in the PROSPER (Prospective Study of Pravastatin in the Elderly at Risk) trial at 6 months postrandomization...
November 27, 2018: Circulation
https://www.readbyqxmd.com/read/30524137/metabolomic-consequences-of-genetic-inhibition-of-pcsk9-compared-with-statin-treatment
#7
Eeva Sliz, Johannes Kettunen, Michael V Holmes, Clare Oliver Williams, Charles Boachie, Qin Wang, Minna Männikkö, Sylvain Sebert, Robin Walters, Kuang Lin, Iona Y Millwood, Robert Clarke, Liming Li, Naomi Rankin, Paul Welsh, Christian Delles, J Wouter Jukema, Stella Trompet, Ian Ford, Markus Perola, Veikko Salomaa, Marjo-Riitta Järvelin, Zhengming Chen, Debbie A Lawlor, Mika Ala-Korpela, John Danesh, George Davey Smith, Naveed Sattar, Adam Butterworth, Peter Würtz
Background: Both statins and PCSK9 inhibitors lower blood low-density lipoprotein cholesterol (LDL-C) levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects of these two lipid-lowering therapies, we performed detailed lipid and metabolite profiling of a large randomized statin trial and compared the results with the effects of genetic inhibition of PCSK9, acting as a naturally occurring trial. Methods: 228 circulating metabolic measures were quantified by nuclear magnetic resonance spectroscopy, including lipoprotein subclass concentrations and their lipid composition, fatty acids, and amino acids, for 5,359 individuals (2,659 on treatment) in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial at 6-months post-randomization...
November 27, 2018: Circulation
https://www.readbyqxmd.com/read/30513970/two-week-exclusive-supplementation-of-modified-ketogenic-nutrition-drink-reserves-lean-body-mass-and-improves-blood-lipid-profile-in-obese-adults-a-randomized-clinical-trial
#8
Hae-Ryeon Choi, Jinmin Kim, Hyojung Lim, Yoo Kyoung Park
The ketogenic diet has long been recommended in patients with neurological disorders, and its protective effects on the cardiovascular system are of growing research interest. This study aimed to investigate the effects of two-week of low-calorie ketogenic nutrition drinks in obese adults. Subjects were randomized to consume drinks either a ketone-to-non-ketone ratio of 4:1 (KD 4:1), a drink partially complemented with protein at 1.7:1 (KD 1.7:1), or a balanced nutrition drink (BD). Changes in body weight, body composition, blood lipid profile, and blood ketone bodies were investigated...
December 3, 2018: Nutrients
https://www.readbyqxmd.com/read/30500340/the-degree-of-postpartum-metabolic-challenge-in-dairy-cows-is-associated-with-peripheral-blood-mononuclear-cell-transcriptome-changes-of-the-innate-immune-system
#9
Sabine Mann, Anja S Sipka, Jennifer K Grenier
Dairy cows undergo a nutrient deficit immediately postpartum when lactational demands exceed nutrient intake. This occurs concurrently to an increased challenge due to bacterial and viral infections, yet ability for pathogen clearance is reduced despite a heightened and often host-damaging inflammatory response. We hypothesized that nutrient stress is associated with differences in the immune cell transcriptome. Our objective was therefore to investigate differentially expressed pathways (DEP) by RNA-seq in peripheral blood mononuclear cells harvested 3 weeks before and 1 week after calving from Holstein cows in low (L, n = 3) or high (H, n = 3) postpartum metabolic stress situations...
November 27, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/30497921/efficacy-and-tolerability-of-olive-oil-based-ketogenic-diet-in-children-with-drug-resistant-epilepsy-a-single-center-experience-from-turkey
#10
Orkide Guzel, Utku Uysal, Nur Arslan
PURPOSE: Ketogenic diet (KD) is an effective non-pharmacological treatment for drug-resistant epilepsy. The aim of this study was to investigate the efficacy, tolerability and complications of olive oil-based KD in epileptic children. METHOD: In this single-center, prospective study, patients were followed up at 1, 3, 6 and 12 months after KD initiation. Initially, blood ketone levels were measured daily, and as needed thereafter to maintain the levels between 4 and 5 mmol/L...
November 20, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/30482009/heterogeneous-clinical-features-of-ketosis-prone-type-2-diabetes-mellitus-patients-gender-age-loss-of-weight-and-hba1c
#11
Juan Wang, Meixiang Zhang, Zhenzhen Liu, Xiujie Wang, Yuanxin Pang, Ye Lu, Zhengqing Liu
BACKGROUND: To observe the clinical features of type 2 diabetes mellitus (T2DM) patients with ketosis as the initial symptom, and investigate its differences from clinical features of non-ketotic T2DM patients. METHODS: A total of 385 T2DM patients treated in our hospital from 2014 to 2017 were selected and divided into ketosis-prone T2DM group and non-ketotic T2DM group. Ketosis-prone T2DM patients refer to DM patients with the urine ketone body++ or above or the blood ketone body ≥1...
November 26, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/30473444/treatment-of-malignant-gliomas-with-ketogenic-or-caloric-restricted-diets-a-systematic-review-of-preclinical-and-early-clinical-studies
#12
REVIEW
Lotte Noorlag, Filip Y De Vos, Annemieke Kok, Marike L D Broekman, Tatjana Seute, Pierre A Robe, Tom J Snijders
BACKGROUND & AIMS: Patients with malignant gliomas have a poor prognosis. Diets that lower blood glucose, such as ketogenic or caloric restricted diets (KCRDs), are hypothesized to reduce tumor growth and improve survival. In this systematic review, we summarize preclinical and clinical data on KCRDs in gliomas. METHODS: We searched PubMed and Embase for preclinical and clinical studies on KCRDs in gliomas, and extracted data on surrogate and clinically relevant endpoints, in accordance with PRISMA statement...
November 14, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/30471902/expression-patterns-of-hepatic-genes-involved-in-lipid-metabolism-in-cows-with-subclinical-or-clinical-ketosis
#13
Yiwei Zhu, Guowen Liu, Xiliang Du, Zhen Shi, Meiyu Jin, Xueying Sha, Xiaobing Li, Zhe Wang, Xinwei Li
Dairy cows with ketosis are characterized by high blood concentrations of ketone bodies and hepatic lipid metabolism disorder. The discrepancies in the abundance of mRNA encoding a variety of hepatic candidate genes in varying degrees of ketotic cows represent specific responses of the liver to the challenge of fatty acids and ketone bodies. Importantly, the expression disorder of hepatic genes involved in lipid metabolism plays a promoting role in the onset and progression of ketosis. Thus, the aim of this study was to investigate the expression patterns of genes involved in the hepatic fatty acids uptake, transport, activation, β-oxidation, synthesis, and esterification in the cows with subclinical ketosis (SCK) or clinical ketosis (CK)...
November 21, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/30451544/associations-between-ketone-bodies-and-fasting-plasma-glucose-in-individuals-with-post-pancreatitis-prediabetes
#14
Sakina H Bharmal, Sayali A Pendharkar, Ruma G Singh, David Cameron-Smith, Maxim S Petrov
CONTEXT: Levels of ketone bodies are altered in both acute pancreatitis and type 1 and type 2 diabetes. However, the role of ketone bodies in the pathogenesis of abnormal glucose metabolism after pancreatitis is largely unknown. OBJECTIVE: To investigate the associations between ketone bodies and glucose homeostasis in individuals with post-pancreatitis prediabetes (PPP) versus normoglycaemia after pancreatitis (NAP). METHODS: Fasting blood samples were analysed for acetoacetate, β-hydroxybutyrate, and markers of glucose metabolism at a median of 26 months after acute pancreatitis...
November 19, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30407284/anti-pd-1-pembrolizumab-induced-autoimmune-diabetes-in-chinese-patient-a-case-report
#15
Sicheng Li, Yi Zhang, Zhichun Sun, Ji Hu, Chen Fang
RATIONALE: Programmed cell death-1 protein (PD-1) antibody is an immune-checkpoint inhibitor that triggers anti-tumor response by enhancing immune response. Although PD-1 antibody has been reported effective in some malignant tumor, it can also induce significant immune-related adverse events (irAEs) such as autoimmune diabetes. PATIENT CONCERNS: A 67-year-old male patient with non-small cell lung cancer (NSCLS) presented with polydipsia, polyuria, weakness, and weight loss after use of anti-programmed cell death-1 antibody therapy...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30385513/point-of-care-measurements-of-blood-ketones-in-newborns
#16
Deborah L Harris, Philip J Weston, Jane E Harding
OBJECTIVE: Babies may use alternative cerebral fuels including ketones when blood glucose concentrations are low, but laboratory ketone measurements are slow and expensive. Point-of-care measurement of ketone concentrations, if sufficiently accurate, may provide useful information for clinical care. PATIENTS AND DESIGN: Eligible babies were 35-42 weeks' gestation, ≤10 days old and admitted to the newborn intensive care unit. At the time of clinically indicated blood tests, additional samples were taken to measure beta-hydroxybutyrate using a point-of-care analyser and the laboratory method...
November 1, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30364093/euglycemic-diabetic-ketoacidosis-in-the-icu-3-case-reports-and-review-of-literature
#17
Pablo Lucero, Sebastián Chapela
Diabetic ketoacidosis (DKA) is an acute complication of diabetes mellitus, both type I and type II, as well as other types with diabetes such gestacional diabetes mellitus. It is characterized by blood glucose levels greater than 250 mg/dL and metabolic acidosis (pH < 7.3 and serum bicarbonate < 15 mEq/dL) with an increased anion gap and the presence of ketone bodies in the blood or urine. Within this pathology, there is a subgroup of pathologies which are characterized by being present with no signs of hyperglycemia, posing a diagnostic challenge due to the absence of the main sign of the pathology and the diversity of their pathophysiology...
2018: Case Reports in Critical Care
https://www.readbyqxmd.com/read/30353770/modulation-of-cerebral-ketone-metabolism-following-traumatic-brain-injury-in-humans
#18
Adriano Bernini, Mojgan Masoodi, Daria Solari, John-Paul Miroz, Laurent Carteron, Nicolas Christinat, Paola Morelli, Maurice Beaumont, Samia Abed-Maillard, Mickael Hartweg, Fabien Foltzer, Philippe Eckert, Bernard Cuenoud, Mauro Oddo
Adaptive metabolic response to injury includes the utilization of alternative energy substrates - such as ketone bodies (KB) - to protect the brain against further damage. Here, we examined cerebral ketone metabolism in patients with traumatic brain injury (TBI; n = 34 subjects) monitored with cerebral microdialysis to measure total brain interstitial tissue KB levels (acetoacetate and β-hydroxybutyrate). Nutrition - from fasting vs. stable nutrition state - was associated with a significant decrease of brain KB (34...
October 24, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/30328578/normal-blood-glucose-and-high-blood-ketones-in-a-critically-unwell-patient-with-t1dm-post-bariatric-surgery-a-case-of-euglycemic-diabetic-ketoacidosis
#19
Jemma Dowsett, Rebecca Humphreys, Robert Krones
Obesity is a global epidemic. Obesity in those with type I diabetes (T1DM) contributes to poor glycemic control and complications. Bariatric surgery as management for obesity is increasing in those with T1DM. However, there is limited data pertaining to these patients and their potential post-operative complications. These complications include severe hyperglycemia and diabetic ketoacidosis (DKA). This case study describes a 43-year-old woman with T1DM whose post-operative period following her bariatric surgery was complicated by euglycemic DKA...
October 17, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/30306778/unusual-high-blood-glucose-in-ketoacidosis-as-first-presentation-of-type-1-diabetes-mellitus
#20
Sebastian Hörber, Sarah Hudak, Martin Kächele, Dietrich Overkamp, Andreas Fritsche, Hans-Ulrich Häring, Andreas Peter, Martin Heni
Diabetic ketoacidosis is a life-threatening complication of diabetes mellitus. It usually occurs in patients with type 1 diabetes where it is typically associated with only moderately increased blood glucose. Here, we report the case of a 52-year-old female patient who was admitted to the emergency unit with severely altered mental status but stable vital signs. Laboratory results on admission revealed very high blood glucose (1687 mg/dL/93.6 mmol/L) and severe acidosis (pH <7) with proof of ketone bodies in serum and urine...
September 25, 2018: Endocrinology, Diabetes & Metabolism Case Reports
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