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https://www.readbyqxmd.com/read/30111034/-studies-on-constituents-of-polygonum-multiflorum-extract-in-vivo-and-in-vitro-based-on-uplc-q-tof-ms
#1
Zhong-Hui Guo, Zhi-Xin Jia, Kui-Kui Chen, Jie Liu, Wen-Juan Xu, Fei-Peng Duan, Zhong Xian, Zi-Yi Wei, Lian-Ming Chen, Hong-Bin Xiao
To explore the drug-induced constituents in vivo of Polygonum multiflorum extract (PM). This study was the first to study the drug-induced constituents in target organ liver. Agilent MassHunter qualitative analysis software and Metabolite ID software were applied for the analysis of retention time, exact relative molecular mass, primary and secondary mass spectrum information based on ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and targeted-MS/MS. By comparison with literature and standards, a total of 5 prototypes and 6 metabolites were identified or tentatively elucidated from the liver samples...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/30101716/hormonal-metabolic-and-hemodynamic-adaptations-to-glycosuria-in-type-2-diabetes-patients-treated-with-sodium-glucose-co-transporter-inhibitors
#2
Eugenio Cersosimo, John M Miles
BACKGROUND & INTRODUCTION: The advent of the sodium-glucose cotransporter-2 inhibitors [SGLT-2i] provides an additional tool to combat diabetes and complications. The use of SGLT-2i leads to effective and durable glycemic control with important reductions in body weight/fat and blood pressure. These agents may delay beta-cell deterioration and improve tissue insulin sensitivity, which might slow the progression of the disease. METHODS & RESULTS: In response to glycosuria, a compensatory rise in endogenous glucose production, sustained by a decrease in plasma insulin with an increase in glucagon has been described...
August 13, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/30079506/sick-day-management-in-children-and-adolescents-with-diabetes
#3
Lori M Laffel, Catarina Limbert, Helen Phelan, Anju Virmani, Jamie Wood, Sabine E Hofer
The tried and true "Back to the Future" approach of frequent monitoring of glucose and ketones, preferably of blood over urine ketones, with timely administration of supplemental insulin along with 24 hour, 7 day a week access to expert health care team advice can successfully manage sick days and prevent progression to DKA in young persons with insulin treated diabetes. This article is protected by copyright. All rights reserved.
August 6, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/30075744/serum-metabolomic-profiling-predicts-synovial-gene-expression-in-rheumatoid-arthritis
#4
Rekha Narasimhan, Roxana Coras, Sara B Rosenthal, Shannon R Sweeney, Alessia Lodi, Stefano Tiziani, David Boyle, Arthur Kavanaugh, Monica Guma
BACKGROUND: Metabolomics is an emerging field of biomedical research that may offer a better understanding of the mechanisms of underlying conditions including inflammatory arthritis. Perturbations caused by inflamed synovial tissue can lead to correlated changes in concentrations of certain metabolites in the synovium and thereby function as potential biomarkers in blood. Here, we explore the hypothesis of whether characterization of patients' metabolomic profiles in blood, utilizing 1 H-nuclear magnetic resonance (NMR), predicts synovial marker profiling in rheumatoid arthritis (RA)...
August 3, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/30067991/detection-of-elevated-ketone-bodies-by-postmortem-1h-mrs-in-a-case-of-fetal-ketoacidosis
#5
Jakob Heimer, Dominic Gascho, Barbara Fliss, Rosa Maria Martinez, Niklaus Zoelch
We report a fetal loss following maternal ketoacidosis in a case of cryptic pregnancy. Biochemical analysis of peripheral blood revealed highly elevated levels of beta-hydroxybutyrate (BHB) in the mother (9.2 mmol/l) and the fetus (4.2 mmol/l). Fetal ketoacidosis with hypoxic-ischemic brain damage was determined to be the cause of death. 1 H-MRS of the right cerebral hemisphere presented with distinctive resonances of BHB and acetone. Acetoacetate and glucose were not detected. Due to reported chronic abuse of ethanol and a period of fasting, alcoholic ketoacidosis was concluded to be the cause of the metabolic disorder...
July 25, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/30056077/unveiling-systemic-organ-disorders-associated-with-impaired-lipid-catabolism-in-fasted-sod1-deficient-mice
#6
Jaeyong Lee, Takujiro Homma, Sho Kobayashi, Naoki Ishii, Junichi Fujii
Oxidative stress triggers the formation of lipid droplets in the liver by stimulating lipogenesis and simultaneously suppresses lipoprotein secretion under hypernutritional conditions. Herein we report on the observation of systemic organ failure that is associated with lipid droplet accumulation in fasting, SOD1-knockout (KO) mice. Upon a three-day fasting period, the KO mice were observed to be vulnerable, could not be rescued by refeeding and had largely died, while wild-type mice were totally recovered...
July 26, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/30041918/rhabdomyolysis-is-it-an-overlooked-dka-complication
#7
Omar Farooq Nafea Al-Azzawi, Manal Khudder Abdul Razak, Surra Jabory Hammody
BACKGROUND: Rhabdomyolysis is considered by some studies as a rare complication of a common disorder of diabetic ketoacidosis, while others consider it as not so uncommon. The mechanism is still not clear but can be attributed to a number of factors like acidosis, hyperglycemia and electrolyte disturbances especially hypophosphatemia and hypokalaemia. Missing it may lead to more serious complications and may prolong and/or complicate full recovery of diabetic ketoacidosis. AIM: The aim of this study was to measure the incidence of rhabdomyolysis among patients presented with diabetic ketoacidosis in the emergency department of Baghdad Teaching hospital, its relation to the severity of diabetic ketoacidosis and the associated electrolytes disturbances...
July 19, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/30037619/ketogenic-diet-for-schizophrenia-nutritional-approach-to-antipsychotic-treatment
#8
Adam Włodarczyk, Mariusz S Wiglusz, Wiesław Jerzy Cubała
Schizophrenia is a mental disorder that mostly appears in the second or third decade of life with no consistent appearance. The first-line pharmacological treatment are antipsychotic drugs, which mainly act by suppressing the activity of dopamine. Unfortunately many of schizophrenic patients suffer from persistent positive or negative symptoms that cannot be fully treated with available medication. With exploration on the possible causes of the disease there is evidence on dopaminergic transmission defects, there is a need to find more holistic way in treating the disease and a diet regimen could be one of them...
September 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/30021521/nutritional-ketosis-delays-the-onset-of-isoflurane-induced-anesthesia
#9
Csilla Ari, Zsolt Kovács, Cem Murdun, Andrew P Koutnik, Craig R Goldhagen, Christopher Rogers, David Diamond, Dominic P D'Agostino
BACKGROUND: Ketogenic diet (KD) and exogenous ketone supplements can evoke sustained ketosis, which may modulate sleep and sleep-like effects. However, no studies have been published examining the effect of ketosis on the onset of general isoflurane induced anesthesia. Therefore, we investigated the effect of the KD and different exogenous ketogenic supplements on the onset of akinesia induced by inhalation of isoflurane. METHODS: We used a high fat, medium protein and low carbohydrate diet (KD) chronically (10 weeks) in the glucose transporter 1 (GLUT1) deficiency (G1D) syndrome mice model and sub-chronically (7 days) in Sprague-Dawley (SPD) rats...
July 18, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/30012937/feasibility-of-skin-acetone-analysis-in-patients-with-cardiovascular-diseases
#10
Tetsuro Yokokawa, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Akiomi Yoshihisa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
BACKGROUND: Breath acetone is reported to be a noninvasive biomarker for heart failure. However, the measurement of this metabolite requires expertize and is not standardized yet. Acetone is also released from the skin; thus, measuring acetone as a skin gas may be easier than breath analysis. METHODS: We analyzed skin acetone collected from 41 hospitalized patients with cardiovascular diseases. Passive samplers were used to measure skin acetone emission. Passive sampler was softly fixed on the surface of forearm skin for 10 hour at night...
July 14, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30006299/changes-in-regional-cerebral-blood-flow-associated-with-a-45-day-course-of-the-ketogenic-agent-caprylidene-in-patients-with-mild-to-moderate-alzheimer-s-disease-results-of-a-randomized-double-blinded-pilot-study
#11
Nare Torosyan, Chakmeedaj Sethanandha, Joshua D Grill, Michelle L Dilley, Jooyeon Lee, Jeffrey L Cummings, Celine Ossinalde, Daniel H Silverman
BACKGROUND: Caprylidene is a ketogen that, when metabolized, produces the ketones beta-hydroxybutyrate and acetoacetate, which can cross the blood brain barrier. It has been hypothesized that ketone bodies can be used as an alternate energy source by neurons with impaired glucose utilization. Caprylidene has been shown to improve cognition in patients with mild-to-moderate Alzheimer's disease (AD) who lacked an AD-predisposing allele (ɛ4) of the gene for apolipoprotein E. In this pilot study, we examined the effects of caprylidene on regional cerebral blood flow (rCBF) in patients with mild to moderate AD...
July 10, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29990298/dihydroxyacetone-as-a-definitive-treatment-for-aluminium-phosphide-poisoning-in-rats
#12
Jafar Ahmadi, Siyavash Joukar, Hussein Anani, Somayyeh Karami-Mohajeri
Aluminium phosphide (AlP), a very toxic pesticide also known as the rice tablet, releases phosphine gas upon contact with water, moisture, or gastric acid. Its mortality rate in humans is 70-100 % due to cardiogenic shock and refractory hypotension. Dihydroxyacetone (DHA) is a simple ketonic carbohydrate, mainly used for sunless skin tanning. It also plays a beneficial role in the treatment of hypotension and cardiogenic shock by restoring blood volume and cellular respiration. The aim of this study was to investigate the its effect on the haemodynamics and electrocardiogram (ECG) in male rats poisoned with AlP...
June 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29986150/a-short-term-intervention-combining-aerobic-exercise-with-medium-chain-triglyceride-mct-is-more-ketogenic-than-either-mct-or-aerobic-exercise-alone-a-comparison-of-normoglycemic-and-pre-diabetic-older-women
#13
Camille Vandenberghe, Christian-Alexandre Castellano, Mathieu Maltais, Mélanie Fortier, Valérie St-Pierre, Isabelle J Dionne, Stephen C Cunnane
OBJECTIVES: Determine whether - (1) a five-day aerobic exercise (AE) program combined with a medium-chain triglyceride (MCT) supplement would increase the plasma ketone response in older women more than either intervention alone, and (2) ketonemia after these combined or separate treatments was alike in normoglycemic (NG) versus pre-diabetic (PD) women. DESIGN: Older women (NG=10; PD=9) underwent a 4 h metabolic study after each of four different treatments: (i) no treatment control, (ii) five days of MCT alone (30 g/day), (iii) one session of 30 min of AE alone, and (iv) five days of MCT and AE combined (MCT+AE)...
July 9, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29982887/ketogenic-diet-delays-spinal-fusion-and-decreases-bone-mass-in-posterolateral-lumbar-spinal-fusion-an-in-vivo-rat-model
#14
Qi Liu, Xiaomeng Wang, Zucheng Huang, Junhao Liu, Jianyang Ding, Xiaolin Xu, Ganggang Kong, Xiuhua Wu, Zhou Yang, Qingan Zhu
BACKGROUND: Ketogenic diet (KD), a low-carbohydrate-and-high-fat diet, causes a metabolic state of ketogenesis and has been used to treat drug-resistance epilepsy. Our recent studies showed KD neuroprotective after spinal cord injury and causing bone loss. Effects of KD on spinal fusion were still unknown. This study was aimed to evaluate effects of KD on spinal fusion in rats. METHODS: Thirty-two Sprague-Dawley rats were randomly divided into KD and standard diet (SD) groups...
July 7, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29962455/detoxification-mechanism-of-%C3%AE-%C3%AE-unsaturated-carbonyl-compounds-in-cigarette-smoke-observed-in-sheep-erythrocytes
#15
Shizuyo Horiyama, Mayuko Hatai, Atsushi Ichikawa, Noriko Yoshikawa, Kazuki Nakamura, Masaru Kunitomo
Highly reactive α,β-unsaturated carbonyl compounds, such as acrolein (ACR), crotonaldehyde (CA) and methyl vinyl ketone (MVK), are environmental pollutants present in high concentrations in cigarette smoke. We have previously found that these carbonyl compounds in cigarette smoke extract (CSE) react with intracellular glutathione (GSH) to produce the corresponding GSH-ACR, GSH-CA and GSH-MVK adducts via Michael addition reaction. These adducts are then further reduced to the corresponding alcohol forms by intracellular aldo-keto reductases in highly metastatic mouse melanoma (B16-BL6) cells and then excreted into the extracellular fluid...
2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29953297/influence-of-exogenous-%C3%AE-hydroxybutyrate-on-walking-economy-and-rating-of-perceived-exertion
#16
Shaun James, Beau Kjerulf Greer
This study investigates the effect of a supplementary ketone, β-hydroxybutyrate (BHB), on walking economy and ratings of perceived exertion in apparently healthy individuals. In a repeated-measures, crossover design, ten non-aerobically trained participants (three males; seven females) performed two stages of a duration-modified Bruce treadmill protocol. Participants blindly consumed either 1 ounce of an exogenous BHB solution (KETO) or a noncaloric placebo (CON) 30 minutes prior to exercise testing. Blood ketone and glucose concentrations were measured prior to supplementation (baseline), immediately before exercise, and after exercise...
June 28, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29951290/oxidative-modification-of-proteins-in-the-process-of-experimental-periodontitis-development
#17
Andrii Demkovych, Yurii Bondarenko, Petro Anatoliyovych Hasiuk
The article reveals patterns of changes in the parameters of oxidative modification of proteins for different periods of the inflammatory process in periodontal tissues during periodontitis. Biochemical researches of phenylhydrazones, aldehyde-, and ketone derivatives of neutral and basic proteins were determined in the blood of white rats on the 7th, 14th, and 30th days of the experimental periodontitis development, as well as in intact animals. The method for determination of the oxidative modification of proteins was based on the interaction of oxidized amino acid residues with 2,4-dinitrophenylhydrazine to form 2,4-dinitrophenylhydrazones...
December 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/29944604/intermittent-running-and-cognitive-performance-after-ketone-ester-ingestion
#18
Mark Evans, Brendan Egan
PURPOSE: Ingestion of exogenous ketones alters the metabolic response to exercise and may improve exercise performance, but has not been explored in variable intensity team sport activity, or for effects on cognitive function. METHODS: On two occasions in a double-blind, randomised crossover design, eleven male team sport athletes performed the Loughborough Intermittent Shuttle Test (Part A, 5x15 min intermittent running; Part B, shuttle run to exhaustion), with a cognitive test battery before and after...
June 25, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29931197/decreased-mitochondrial-respiration-in-aneurysmal-aortas-of-fibulin-4-mutant-mice-is-linked-to-pgc1a-regulation
#19
I van der Pluijm, J Burger, P M van Heijningen, A IJpma, N van Vliet, C Milanese, K Schoonderwoerd, W Sluiter, L J Ringuette, D H W Dekkers, I Que, E L Kaijzel, L Te Riet, E MacFarlane, D Das, R van der Linden, M Vermeij, J A Demmers, P G Mastroberardino, E C Davis, H Yanagisawa, H Dietz, R Kanaar, J Essers
Aim: Thoracic aortic aneurysms are a life-threatening condition often diagnosed too late. To discover novel robust biomarkers, we aimed to better understand the molecular mechanisms underlying aneurysm formation. Methods and Results: In Fibulin-4R/R mice, the extracellular matrix protein Fibulin-4 is 4-fold reduced, resulting in progressive ascending aneurysm formation and early death around 3 months of age. We performed proteomics and genomics studies on Fibulin-4R/R mouse aortas...
June 21, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29923997/euglycemic-diabetic-ketoacidosis-caused-by-dapagliflozin-a-case-report
#20
Yu-Mou Chou, Chen-June Seak, Zhong Ning Leonard Goh, Joanna Chen-Yeen Seak, Chen-Ken Seak, Chih-Chuan Lin
RATIONALE: Diabetic ketoacidosis is a serious and potentially life-threatening acute complication of diabetes mellitus (DM). Euglycemic diabetic ketoacidosis (eDKA) is however challenging to identify in the emergency department (ED) due to absence of marked hyperglycemia, often leading to delayed diagnosis and treatment. eDKA has been recently found to be associated with sodium-glucose cotransporter 2 (SGLT2) inhibitors, one of the newest classes of antidiabetics, though there are very limited reports implicating dapagliflozin as the offending agent in ED patients...
June 2018: Medicine (Baltimore)
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