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Clinical study of hydrocephalus

N Brawanski, M Bruder, S Y Won, S Tritt, J Berkefeld, C Senft, V Seifert, J Konczalla
Patients with ruptured aneurysms of carotid bifurcation artery seem to suffer less often from cerebral vasospasm and early brain injury and have a better clinical outcome. Aim of our study was to identify differences in clinical course and outcome in aneurysms of terminus segments (carotid bifurcation artery and basilar tip) compared to aneurysms of other aneurysm locations except carotid bifurcation artery and basilar tip. Patients with SAH were entered into a prospectively collected database (1999 to June 2014)...
December 12, 2018: Neurosurgical Review
Wen-Jian-Long Zhou, Xi Wang, Jia-Yi Peng, Shun-Chang Ma, Dai-Nan Zhang, Xiu-Dong Guan, Jin-Fu Diao, Jian-Xing Niu, Chun-De Li, Wang Jia
Background: Decision-making concerning the treatment of choroid plexus tumor (CPT) in pediatric patients remains a topic of considerable debate. The aim of this work was to describe clinical features and prognostic risk factors of CPT in the pediatric population and to provide theoretical opinions regarding clinical decisions for CPT. Methods: The data of 96 patients with CPT and younger than 14 years were retrospectively analyzed. Clinical characteristics such as pathological type of CPTs, rate and severity of hydrocephalus, treatment and outcome, and recurrence were investigated...
December 20, 2018: Chinese Medical Journal
Nail Özdemir, Senem Alkan Özdemir, Esra Arun Özer
PURPOSE: Kyphosis is the most severe spinal deformity associated with meningomyelocele (MMC) and is seen in approximately 15% of neonates. Our purpose is to present our clinical experience, to discuss the technique and deformity correction in kyphectomy in neonates with MMC, and to assess its long-term outcomes. METHOD: In this prospective study, the authors reviewed eight cases submitted to surgery between 2013 and 2015. We evaluated clinical characteristics that were analyzed, as were the operative technique employed, and angle range of the kyphosis deformity postcorrection follow-up...
December 11, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Rohen Harrichandparsad, Syed Sameer Nadvi, Mahomed-Yunus Suleman Moosa, James Rikus van Dellen
BACKGROUND: In 2000 we advised against insertion of a ventriculo-peritoneal shunt (VPS) in Human Immunodeficiency Virus (HIV) positive patients with tuberculous meningitis (TBM) complicated by hydrocephalus. However, this was in the era when combination antiretroviral therapy (ART) was not freely available in South Africa. In this subsequent preliminary report, we describe the outcome of ventriculo-peritoneal (VP) shunting in patients with TBM and hydrocephalus that are HIV positive and receiving ART...
December 6, 2018: World Neurosurgery
Shafqat Rasul Chaudhry, Stilla Frede, Gerald Seifert, Thomas Mehari Kinfe, Mika Niemelä, Alf Lamprecht, Sajjad Muhammad
Aneurysmal subarachnoid hemorrhage (aSAH) is a highly complex disease. Majority of aSAH survivors confront post-SAH complications including cerebral vasospasm (CVS) and delayed cerebral ischemia (DCI) that mainly influence the clinical outcome. Tissue damage during early brain injury may lead to release of damage associated molecular pattern molecules (DAMPs) that may initiate and sustain inflammation during the course of aSAH through activation of pattern recognition receptors. Mitochondrial DNA (mtDNA) due to unmethylated CpG motifs acts as a DAMP via binding to toll-like receptor-9...
December 5, 2018: Mitochondrion
S Agerskov, M Wallin, P Hellström, D Ziegelitz, C Wikkelsö, M Tullberg
BACKGROUND AND PURPOSE: Several studies have evaluated the use of MR imaging markers for the prediction of outcome after shunt surgery in idiopathic normal pressure hydrocephalus with conflicting results. Our aim was to investigate the predictive value of a number of earlier proposed morphologic MR imaging markers in a large group of patients with idiopathic normal pressure hydrocephalus. MATERIALS AND METHODS: One hundred sixty-eight patients (mean age, 70 ± 9...
December 6, 2018: AJNR. American Journal of Neuroradiology
D Sylvain Zabsonre, Henri Lankoande, Chantal F C Zoungrana/Ouattara, Abdoulaye Thiombiano, Soumaila Ouedraogo, Abdoulaye Sanou, Pacome Yameogo, Sonia J E Kaboret-Douamba, Abel Kabre
BACKGROUND: Neural tube defects (spina bifidas or cephaloceles) are congenital malformations that can be associated with hydrocephalus. Even if the surgical management of each of these pathologies separately is well established, this is not the case for a combination of these conditions. AIM: To report our results of simultaneous or separate surgery for the association of hydrocephalus with neural tube defect in the same patient. METHODS: This was a retrospective study of the association of hydrocephalus with neural tube defect (spina bifida or cephalocele) managed over a period of 7 years at the Department of Neurosurgery, Yalgado Ouedraogo University Hospital, Ouagadougou, Burkina Faso...
December 5, 2018: Pediatric Neurosurgery
Guangfu Di, Yuhai Zhang, Hua Liu, Xiaochun Jiang, Yong Liu, Kun Yang, Jiu Chen, Hongyi Liu
OBJECTIVE: Postoperative complications are common in patients who underwent decompressive craniectomy (DC) after traumatic brain injury (TBI). However, little is known about the degree of association between the postoperative complications and the long-term outcome of adult TBI patients after DC. The aim of this study was to evaluate the risk of postoperative complications that influenced the long-term outcome of DC in TBI patients. METHOD: A total of 121 patients were studied up to 6 months after DC in TBI...
December 4, 2018: Brain and Behavior
Zhimei Guo, Fang Liu, Hai Jun Li
BACKGROUND: Kabuki syndrome (KS) is a rare congenital anomaly syndrome affecting multiple organs. Two genes have been shown to be mutated in patients with KS: lysine (K)-specific demethylase 6A (KDM6A) and lysine (K)-specific methyltransferase 2D (KMT2D, formerly MLL2). Although the congenital clinical characteristic is helpful in diagnosis of the KS, there are no reports of specific findings in fetuses that might suggest the syndrome prenatally. CASE PRESENTATION: In this study, we described a male patient with a novel KDM6A splicing in exon(exon4) and flanking intron(intron3)-exon boundaries characterized by congenital hydrocephalus which had never been reported before...
December 3, 2018: BMC Medical Genetics
Amr Ali Hasanain, Ahmed Abdullah, Mohamed F M Alsawy, Mohamed A R Soliman, Ammar Ali Ghaleb, Reem Elwy, Ahmed A M Ezzat, Ahmed Al Menabbawy, Ahmed A Marei, Bassante Abd El Razik, Mostafa I El Hamaky, Henry W S Schroeder, Steffen Fleck, Ahmed El Damaty, Sascha Marx, Stephan Nowak, Jörg Baldauf, Ahmed Zohdi, Ehab Ahmed El Refaee
OBJECTIVES:  Ventriculoperitoneal (VP) shunting is commonly used to treat pediatric hydrocephalus, but failure rates are high. VP shunt failure in children is mostly caused by infection and/or proximal/distal shunt obstruction. However, to our knowledge, no previous reviews have discussed this topic using only clinical studies when age-related data could be obtained. This systematic review aimed at reevaluating what is already known as the most common causes of shunt failure and to determine the incidence and causes of VP shunt failure during the first 2 years of life as a step to establish solid evidence-based guidelines to avoid VP shunt failure in infants...
December 3, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Nathaniel B Gunter, Christopher G Schwarz, Jonathan Graff-Radford, Jeffrey L Gunter, David T Jones, Neill R Graff-Radford, Ronald C Petersen, David S Knopman, Clifford R Jack
OBJECTIVE: Create an automated classifier for imaging characteristics of disproportionately enlarged subarachnoid space hydrocephalus (DESH), a neuroimaging phenotype of idiopathic normal pressure hydrocephalus (iNPH). METHODS: 1597 patients from the Mayo Clinic Study of Aging (MCSA) were reviewed for imaging characteristics of DESH. One core feature of DESH, the presence of tightened sulci in the high-convexities (THC), was used as a surrogate for the presence of DESH as the expert clinician-defined criterion on which the classifier was trained...
November 19, 2018: NeuroImage: Clinical
So Young Kim, Jung Won Choi, Hyung-Jin Shin, So Young Lim
PURPOSE: Systematic examination of increased intracranial pressure (ICP) is important during the follow-up period after surgical repair of syndromic craniosynostosis. In these patients, postoperative progress can be unclear due to the involvement of multiple sutures and the high incidence of relapse due to the progressive nature of the disease and to genetic variability. In this study, we investigated the clinical manifestations of increased ICP in syndromic craniosynostosis patients before and after surgery...
November 12, 2018: Journal of Cranio-maxillo-facial Surgery
(no author information available yet)
OBJECTIVEAlthough endoscopic third ventriculostomy (ETV) for the treatment of hydrocephalus was introduced in 1923, the method was relegated to the sidelines in favor of extracranial techniques. Since the 1990s to the beginning of the current century, however, ETV has undergone a remarkable resurgence to become the first-line treatment for obstructive hydrocephalus, and for some groups, the procedure has been applied for communicating hydrocephalus as well. In the present study, the authors identified the top 50 cited ETV works...
October 1, 2018: Journal of Neurosurgery. Pediatrics
(no author information available yet)
OBJECTIVEThe majority of children with myelomeningocele undergo implantation of CSF shunts. The efficacy of adding surveillance imaging to clinical evaluation during routine follow-up as a means to minimize the hazard associated with future shunt failure has not been thoroughly studied.METHODSA total of 300 spina bifida clinic visits during the calendar years between 2012 and 2016 were selected for this study (defined as the index clinic visit). Each index visit was preceded by a 6-month period during which no shunt evaluation of any kind was performed...
October 1, 2018: Journal of Neurosurgery. Pediatrics
(no author information available yet)
OBJECTIVEMany studies have aimed to determine the most clinically effective surgical intervention for hydrocephalus. However, the costs associated with each treatment option are poorly understood. In this study, the authors conducted a cost-effectiveness analysis, calculating the incremental cost-effectiveness ratio (ICER) of ventriculoperitoneal shunting (VPS), endoscopic third ventriculostomy (ETV), and ETV with choroid plexus cauterization (ETV/CPC) in an effort to better understand the clinical effectiveness and costs associated with treating hydrocephalus...
October 1, 2018: Journal of Neurosurgery. Pediatrics
(no author information available yet)
OBJECTIVEHarvey Cushing (1869-1939) coined the term "craniopharyngioma" (CP) in 1929 to describe a kaleidoscopic group of epithelial tumors involving the hypothalamic-pituitary axis. Throughout his career, he endured a long struggle to accurately diagnose and safely remove these complex lesions, and his resulting surgical series has never before been analyzed in depth. The authors here conduct such an analysis.METHODSIn this study, the authors retrospectively examined the CP patient records available in the Cushing Brain Tumor Registry, as well as those CP cases reported by Cushing in medical monographs and scientific reports...
October 1, 2018: Journal of Neurosurgery
(no author information available yet)
OBJECTIVEIntracranial pressure (ICP), outflow resistance (Rout), and amplitude of cardiac-related ICP pulsations (AMPs) are established parameters to describe the CSF hydrodynamic system and are assumed, but not confirmed, to be disturbed in idiopathic normal pressure hydrocephalus (INPH). The aim of this study was to compare the CSF hydrodynamic profile between patients with INPH and healthy volunteers.METHODSSixty-two consecutive INPH patients (mean age 74 years) and 40 healthy volunteers (mean age 70 years) were included...
November 1, 2018: Journal of Neurosurgery
(no author information available yet)
OBJECTIVEOcclusive treatment of posterior communicating artery (PCoA) aneurysms has been seen as a fairly uncomplicated procedure. The objective here was to determine the radiological and clinical outcome of patients after PCoA aneurysm rupture and treatment and to evaluate the risk factors for impaired outcome.METHODSIn a retrospective clinical follow-up study, data were collected from 620 consecutive patients who had been treated for ruptured PCoA aneurysms at a single center between 1980 and 2014. The follow-up was a minimum of 1 year after treatment or until death...
October 1, 2018: Journal of Neurosurgery
Ahmet Aciduman, Önder Ilgili, Çağatay Aşkit, Kemal Tuzcu
OBJECTIVES: This study aimed to present and evaluate the part of Avenzoar's Liber Teisir that pertains to hydrocephalus. Avenzoar was an Andalusian physician prominent in the history of medicine because of the broadness of his observations and original methods. His most important work is recognized to be the Al-Taysīr fī al-Mudāwāt wa al-Tadbīr (On Preventive Regimen and Treatment), and its Latin version, Alteisir scilicet regiminis et medelae, was in use for centuries in Europe...
November 22, 2018: World Neurosurgery
Zhenxing Li, Jigang Chen, Danfeng Zhang, Liquan Lv, Lijun Hou
BACKGROUND: Paroxysmal sympathetic hyperactivity (PSH) is an uncommon complication of severe traumatic brain injury (sTBI). Clinical risk factors for PSH have not been fully characterized, especially on tracheostomy which is usually recommended for patients with sTBI to facilitate the treatment. PURPOSE: We aimed to examine the effect of tracheostomy on PSH incidence in sTBI. METHODS: This single-centered, retrospective study was conducted based on consecutive patients with sTBI admitted to the Shanghai Changzheng Hospital from January 1, 2013 to March 31, 2018...
November 21, 2018: World Neurosurgery
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