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https://www.readbyqxmd.com/read/28521860/-hiv-pre-exposure-prophylaxis-prep-the-three-should-not-prevent-seing-the-forest
#1
Jordi Casabona
No abstract text is available yet for this article.
May 15, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28516485/simultaneous-measurement-of-t2-and-apparent-diffusion-coefficient-t2-adc-in-the-heart-with-motion-compensated-spin-echo-diffusion-weighted-imaging
#2
Eric Aliotta, Kévin Moulin, Zhaohuan Zhang, Daniel B Ennis
PURPOSE: To evaluate a technique for simultaneous quantitative T2 and apparent diffusion coefficient (ADC) mapping in the heart (T2 +ADC) using spin echo (SE) diffusion-weighted imaging (DWI). THEORY AND METHODS: T2 maps from T2 +ADC were compared with single-echo SE in phantoms and with T2 -prepared (T2 -prep) balanced steady-state free precession (bSSFP) in healthy volunteers. ADC maps from T2 +ADC were compared with conventional DWI in phantoms and in vivo. T2 +ADC was also demonstrated in a patient with acute myocardial infarction (MI)...
May 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28514200/culturally-competent-sexual-healthcare-as-a-prerequisite-for-obtaining-preexposure-prophylaxis-findings-from-a-qualitative-study
#3
Kevin M Maloney, Douglas S Krakower, Dale Ziobro, Joshua G Rosenberger, David Novak, Kenneth H Mayer
PURPOSE: Men who have sex with men (MSM) experience stigma in healthcare settings, which impedes disclosure of sexual behavior, potentially limiting uptake of preexposure prophylaxis (PrEP). The purpose of this study was to describe the context of this limitation and explore geographical variability. METHODS: To understand how discomfort in healthcare settings affects PrEP utilization, we conducted two online focus groups with geographically diverse samples of MSM...
May 17, 2017: LGBT Health
https://www.readbyqxmd.com/read/28513816/italian-guidelines-for-the-use-of-antiretroviral-agents-and-the-diagnostic-clinical-management-of-hiv-1-infected-persons-update-2016
#4
Andrea Antinori, Antonio Di Biagio, Simone Marcotullio, Massimo Andreoni, Antonio Chirianni, Antonella d'Arminio Monforte, Massimo Galli, Francesco Mazzotta, Cristina Mussini, Massimo Puoti, Adriano Lazzarin
The Italian Society of Infectious and Tropical Diseases (SIMIT) of the Technical Health Committee, Ministry of Health (Sections L and M) of Italy have supported recommendations for the Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. This publication summarizes the latest updates to the 2016 version of the Italian Guidelines for the management of HIV-1 infected patients and the use of antiretroviral drugs. In particular, new recommendations were released concerning the following topics: estimate of the HIV continuum of care in Italy, optimal timing and preferred drug combinations for starting antiretroviral therapy, treatment optimization, and pre-exposure prophilaxis (PrEP)...
April 2017: New Microbiologica
https://www.readbyqxmd.com/read/28505240/incidence-of-gonorrhea-and-chlamydia-following-hiv-preexposure-prophylaxis-among-men-who-have-sex-with-men-a-modeling-study
#5
Samuel M Jenness, Kevin M Weiss, Steven M Goodreau, Thomas Gift, Harrell Chesson, Karen W Hoover, Dawn K Smith, Albert Y Liu, Patrick S Sullivan, Eli S Rosenberg
Background: Preexposure prophylaxis (PrEP) is highly effective for preventing HIV, but risk compensation (RC) in men who have sex with men (MSM) raises concerns about increased sexually transmitted infections (STIs). CDC's PrEP guidelines recommend biannual STI screening, which may reduce incidence by treating STIs that would otherwise remain undiagnosed. We investigated the impact of these two potentially counteracting phenomena. Methods: With a stochastic network-based mathematical model of HIV and rectal/urogenital Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) transmission dynamics among MSM in the United States, we simulated PrEP uptake following the prescription indications and HIV/STI screening recommendations in the CDC guidelines...
May 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28504847/implementation-of-a-digital-preparation-validation-tool-in-dental-skills-laboratory-training
#6
A Kozarovska, C Larsson
AIM: To describe the implementation of a digital tool for preparation validation and evaluate it as an aid in students' self-assessment. METHODS: Students at the final semester of skills laboratory training were asked to use a digital preparation validation tool (PVT) when performing two different tasks; preparation of crowns for teeth 11 and 21. The students were divided into two groups. Group A self-assessed and scanned all three attempts at 21 ("prep-and-scan")...
May 15, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/28501964/consensus-statement-supporting-safer-conception-and-pregnancy-for-men-and-women-living-with-and-affected-by-hiv
#7
Lynn T Matthews, Jolly Beyeza-Kashesya, Ian Cooke, Natasha Davies, Renee Heffron, Angela Kaida, John Kinuthia, Okeoma Mmeje, Augusto E Semprini, Shannon Weber
Safer conception interventions reduce HIV incidence while supporting the reproductive goals of people living with or affected by HIV. We developed a consensus statement to address demand, summarize science, identify information gaps, outline research and policy priorities, and advocate for safer conception services. This statement emerged from a process incorporating consultation from meetings, literature, and key stakeholders. Three co-authors developed an outline which was discussed and modified with co-authors, working group members, and additional clinical, policy, and community experts in safer conception, HIV, and fertility...
May 13, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28501046/reporting-pre-exposure-prophylaxis-use-in-craigslist-personal-advertisements-among-men-seeking-sex-with-men-in-the-united-states
#8
Brandon J Hill, Trevor Bak, Alicia VandeVusse, Kris Rosentel
This study describes the self-reported use of pre-exposure prophylaxis (PrEP) in the personal advertisements of men seeking sex with men in the United States on the online classified advertisement site, Craigslist. Overall self-reported PrEP use was low (0.20%; 95% confidence interval (CI)=0.18-0.22). However, PrEP use in personal ads was described in conjunction with seeking sexual risk behaviours including 'bareback' sex (22.7%; 95% CI=17.7-27.7%) and sex with substance use (26.8%; 95% CI=21.5-32.1%). Only 4...
May 15, 2017: Sexual Health
https://www.readbyqxmd.com/read/28498144/the-impact-of-preexposure-prophylaxis-among-men-who-have-sex-with-men-an-individual-based-model
#9
Parastu Kasaie, Jeff Pennington, Maunank S Shah, Stephen A Berry, Danielle German, Colin P Flynn, Chris Beyrer, David W Dowdy
OBJECTIVES: Preexposure prophylaxis (PrEP) is recommended for preventing HIV infection among individuals at high risk, including men who have sex with men (MSM). Although its individual-level efficacy is proven, questions remain regarding population-level impact of PrEP implementation. DESIGN: We developed an agent-based simulation of HIV transmission among MSM, accounting for demographics, sexual contact network, HIV disease stage, and use of antiretroviral therapy...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28495344/does-adoption-of-electronic-health-records-improve-the-quality-of-care-management-in-france-results-from-the-french-e-si-preps-sips-study
#10
Morgane Plantier, Nathalie Havet, Thierry Durand, Nicolas Caquot, Camille Amaz, Pierre Biron, Irène Philip, Lionel Perrier
BACKGROUND: Electronic health records (EHR) are increasingly being adopted by healthcare systems worldwide. In France, the "Hôpital numérique 2012-2017" program was implemented as part of a strategic plan to modernize health information technology (HIT), including the promotion of widespread EHR use. With significant upfront investment costs as well as ongoing operational expenses, it is important to assess this system in terms of its ability to result in improvements in hospital performances...
June 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28487025/mouse-prolyl-oligopeptidase-plays-a-role-in-trophoblast-stem-cell-differentiation-into-trophoblast-giant-cell-and-spongiotrophoblast
#11
Yuki Maruyama, Shin Matsubara, Atsushi P Kimura
INTRODUCTION: Prolyl oligopeptidase (prolyl endopeptidase, Prep), a multifunctional protease hydrolyzing -Pro-X- peptide bonds, is highly expressed in the mouse placenta, but the function during development is not known. We explored the possibility of Prep's involvement in placental differentiation. METHODS: We cultured trophoblast stem cells (TSCs) derived from the E6.5 mouse embryo and investigated the detailed expression pattern of Prep during their differentiation...
May 2017: Placenta
https://www.readbyqxmd.com/read/28481784/distribution-of-behavioral-patterns-prior-to-infection-among-san-francisco-men-who-have-sex-with-men-newly-infected-with-hiv-in-2014
#12
Yea-Hung Chen, Willi McFarland, H Fisher Raymond, Hyman M Scott, Eric Vittinghoff, Travis C Porco
BACKGROUND: Despite continued reductions in the number of HIV cases reported among San Francisco men who have sex with men (MSM) and the HIV-prevention potential offered by pharmaceutical tools such as pre-exposure prophylaxis (PrEP), there are uncertainties, particularly given reported decreases in consistent condom use. A key uncertainty is what groups of MSM should be targeted. The present study estimates the distribution of behavioral patterns prior to infection among San Francisco MSM newly infected with HIV in 2014...
May 5, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28480682/adherence-and-characteristics-of-hiv-post-exposure-prophylaxis-for-a-population-in-tel-aviv-of-men-who-have-sex-with-men
#13
Noam Oz, Danny Alon, Gideon Y Stein, Dan Turner
BACKGROUND: Pre-exposure prophylaxis (PrEP) for populations at high risk for human immunodeficiency virus (HIV) is still not available in Israel. OBJECTIVES: To analyze post-exposure prophylaxis (PEP) treatment adherence rates among adult men in Tel Aviv, Israel, who have sex with men (MSM), and to obtain data on the demographics of PEP users, exposure types, timeline of exposure and PEP administration, incidence of side effects, number of treatments per individual, and satisfaction with selected elements of treatment provision...
April 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28480276/prescribing-of-human-immunodeficiency-virus-hiv-pre-exposure-prophylaxis-by-hiv-medical-providers-in-the-united-states-2013-2014
#14
John Weiser, Shikha Garg, Linda Beer, Jacek Skarbinski
BACKGROUND: Clinical trials have demonstrated the effectiveness of human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) for reducing HIV acquisition. Understanding how HIV care providers are prescribing PrEP is necessary to ensure success of this prevention strategy. METHODS: During 2013-2014, we surveyed US HIV care providers who also provided care to HIV-negative patients. We estimated percentages who had prescribed PrEP and assessed associations between provider characteristics and PrEP prescribing...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28478870/intent-to-use-preexposure-prophylaxis-prep-hiv-risk-behaviors-and-self-report-neurocognitive-symptoms-by-high-risk-drug-users-a-mediation-analysis
#15
Roman Shrestha, Pramila Karki, Tania B Huedo-Medina, Michael Copenhaver
Neurocognitive impairment (NCI) and HIV risk are significant correlates of intent to use preexposure prophylaxis (PrEP). The extent to which similar outcomes could occur when these factors operate together, particularly for people who use drugs (PWUD), remains an important unanswered question. We therefore sought evidence that HIV risk behavior mediated the relationship between NCI and intent to use PrEP in high-risk PWUD in treatment. HIV-uninfected, methadone-maintained people who reported HIV-risk behaviors were enrolled (n = 400)...
April 19, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28468533/willingness-to-use-short-term-oral-pre-exposure-prophylaxis-prep-by-migrant-miners-and-female-partners-of-migrant-miners-in-mozambique
#16
Joana Falcao, Laurence Ahoua, Allison Zerbe, Pietro di Mattei, Rachel Baggaley, Victor Chivurre, Prince Mulondo, Isaias Ramiro, Shona Dalal, Fernando Morales, Kevin O'Reilly, Wafaa El-Sadr
Migrant miners from Mozambique who work in South Africa and their partners are at substantial risk for HIV infection. We conducted a cross-sectional study to assess the willingness of migrant miners and female partners of miners to take short-term pre-exposure prophylaxis (PrEP) for prevention of HIV acquisition. The study was conducted in Gaza Province, Mozambique, between September and October 2015. A total of 131 male miners and female partners of male miners completed a questionnaire. Subsequently, 48 in-depth interviews among male miners and female partners of miners and 3 focus-group discussions (6 participants each) among female partners of miners were conducted...
May 4, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28467163/perspectives-on-hiv-pre-and-post-exposure-prophylaxes-prep-and-pep-among-female-and-male-sex-workers-in-mombasa-kenya-implications-for-integrating-biomedical-prevention-into-sexual-health-services
#17
Arjee J Restar, Jack Ume Tocco, Joanne E Mantell, Yves Lafort, Peter Gichangi, Tsitsi B Masvawure, Sophie Vusha Chabeda, Theo G M Sandfort
Pre- and post-exposure prophylaxes (PrEP and PEP) can reduce the risk of HIV acquisition, yet often are inaccessible to and underutilized by most-vulnerable populations, including sex workers in sub-Saharan Africa. Based on in-depth interviews with 21 female and 23 male HIV-negative sex workers in Mombasa, Kenya, we found that awareness and knowledge of PrEP and PEP were low, although willingness to use both was high. Participants felt PrEP would be empowering and give added protection against infection, although some expressed concerns about side effects...
April 2017: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/28463880/medication-adherence-condom-use-and-sexually-transmitted-infections-in-australian-prep-users-interim-results-from-the-victorian-prep-demonstration-project
#18
Luxi Lal, Jennifer Audsley, Dean Murphy, Christopher K Fairley, Mark Stoove, Norm Roth, Richard Moore, B K Tee, Nalagafiar Puratmaja, Peter L Anderson, David Leslie, Robert M Grant, John De Wit, Edwina Wright
OBJECTIVE: HIV Pre-exposure prophylaxis (PrEP) decreases risk of HIV acquisition however its efficacy is closely dependent on adherence. There is also concern that the preventive effect of PrEP may be offset by risk compensation, notably an increase in condomless anal sex. DESIGN: Multi-site, open-label demonstration study that recruited people at current or recent risk of HIV infection in Melbourne, Australia. METHODS: Participants were recruited from three general practice clinics and one sexual health clinic in Melbourne and consented to take daily tenofovir/emtricitabine for 30 months...
May 1, 2017: AIDS
https://www.readbyqxmd.com/read/28463878/men-who-have-sex-with-men-starting-pre-exposure-prophylaxis-prep-are-at-risk-of-hcv-infection-evidence-from-the-amsterdam-prep-study
#19
Elske Hoornenborg, Roel C A Achterbergh, Maarten F Schim Van Der Loeff, Udi Davidovich, Arjan Hogewoning, Henry J C de Vries, Janke Schinkel, Maria Prins, Thijs J W van de Laar
OBJECTIVES AND DESIGN: Hepatitis C virus (HCV) has been recognised as an emerging sexually transmitted infection (STI) among HIV-positive men who have sex with men (MSM). However, HIV-negative MSM at high risk for HIV might also be at increased risk for HCV. We studied the HCV prevalence in HIV-negative MSM who start pre-exposure prophylaxis (PrEP) in Amsterdam. Phylogenetic analysis was used to compare HCV strains obtained from HIV-negative and HIV-positive MSM. METHODS: At enrolment in the Amsterdam PrEP (AMPrEP) demonstration project, HIV-negative MSM were tested for the presence of HCV antibodies and HCV RNA...
May 1, 2017: AIDS
https://www.readbyqxmd.com/read/28463131/nelly-mugo-rolling-out-prep-in-kenya
#20
Tony Kirby
No abstract text is available yet for this article.
April 29, 2017: Lancet
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