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Unresectability AND cholangiocarcinoma

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https://www.readbyqxmd.com/read/30092710/foreign-body-granuloma-reaction-following-sirt-mimicking-peritoneal-metastases-a-word-of-caution
#1
Edward Willems, Bart Smet, Franceska Dedeurwaerdere, Mathieu D'Hondt
Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver malignancy with poor survival rates. Surgical resection is the only curative treatment option, yet only a small portion of cases are resectable. In unresectable situations, suggested therapy consists of a systemic chemotherapy regimen with cisplatinum and gemcitabine. Selective internal radiation therapy (SIRT) has been proposed as an alternative treatment option and may lead to downstaging of unresectable iCCA to surgery. We present a case of a female patient diagnosed with an unresectable iCCA treated with SIRT in order to obtain downstaging...
August 9, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/30076591/clinical-value-of-inflammation-based-prognostic-scores-to-predict-the-resectability-of-hyperbilirubinemia-patients-with-potentially-resectable-hilar-cholangiocarcinoma
#2
Hai-Jie Hu, Yan-Wen Jin, Rong-Xing Zhou, Wen-Jie Ma, Qin Yang, Jun-Ke Wang, Fei Liu, Nan-Sheng Cheng, Fu-Yu Li
BACKGROUND: We aimed to examine whether inflammation-based prognostic scores could predict tumor resectability in a cohort of hilar cholangiocarcinoma patients with preoperative hyperbilirubinemia. We also sought to investigate the prognostic factors associated with overall survival in the subgroup of patients with an R0 resection. METHODS: A total of 173 patients with potentially resectable hilar cholangiocarcinoma, as judged by radiological examinations, were included...
August 3, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/30062070/successful-management-of-an-unresectable-intrahepatic-cholangiocarcinoma-with-neoadjuvant-systemic-therapy-chemoembolization-and-extended-hepatectomy-with-portal-vein-reconstruction
#3
Colin K Cantrell, Jared White
Cholangiocarcinoma is a rare, but invariably fatal primary hepatic tumor that is often diagnosed at advanced stages with minimal options of surgical cure. Relatively few patients diagnosed with cholangiocarcinoma are considered surgical candidates, owing to the extent of the disease at presentation, the presence of vascular invasion or extrahepatic disease, and/or poor functional status with advanced age being most commonly associated. There is no clear consensus for the management of advanced cholangiocarcinomas, as the current literature is typically based on limited patient numbers and anecdotal experiences at best...
May 28, 2018: Curēus
https://www.readbyqxmd.com/read/30056241/a-comparative-effectiveness-meta-analysis-of-photodynamic-therapy-and-stent-drainage-for-unresectable-cholangiocarcinoma
#4
Xingwei Zhang, Rui Mo, Huijun Zhao, Xi Luo, Yunsheng Yang
BACKGROUND: Photodynamic therapy (PDT) combined with biliary stent showed therapeutic effect in the palliative treatment of unresectable cholangiocarcinoma (CC). We aimed to evaluate the survival outcomes and procedure-related complications of PDT compared to conventional stenting for CC patients. METHODS: Databases including Pubmed, Medline, Embase and Cochrane Central Database were systematically searched from inception to December 2017 for clinical trials compared photodynamic therapy with biliary stenting...
July 26, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/30049012/-french-comment-on-article-efficacy-and-safety-of-endoscopic-radiofrequency-ablation-for-unresectable-extrahepatic-cholangiocarcinoma-a-randomized-trial1
#5
(no author information available yet)
No abstract text is available yet for this article.
August 2018: Endoscopy
https://www.readbyqxmd.com/read/30042074/intrahepatic-cholangiocarcinoma-treated-with-transarterial-yttrium-90-glass-microsphere-radioembolization-results-of-a-single-institution-retrospective-study
#6
Alexandra Gangi, Jehan Shah, Nathan Hatfield, Johnna Smith, Jennifer Sweeney, Junsung Choi, Ghassan El-Haddad, Benjamin Biebel, Nainesh Parikh, Bulent Arslan, Sarah E Hoffe, Jessica M Frakes, Gregory M Springett, Daniel A Anaya, Mokenge Malafa, Dung-Tsa Chen, Yunyun Chen, Richard D Kim, Ravi Shridhar, Bela Kis
PURPOSE: To evaluate the efficacy and safety of transarterial yttrium-90 glass microsphere radioembolization in patients with unresectable intrahepatic cholangiocarcinoma (ICC). MATERIALS AND METHODS: Retrospective review of 85 consecutive patients (41 men and 44 women; age, 73.4 ± 9.3 years) was performed. Survival data were analyzed by the Kaplan-Meier method, Cox regression models, and the log-rank test. RESULTS: Median overall survival (OS) from diagnosis was 21...
August 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/30027911/the-efficacy-of-temporary-placement-of-nasobiliary-drainage-following-endoscopic-metal-stenting-to-prevent-post-ercp-cholangitis-in-patients-with-cholangiocarcinoma
#7
Xinjian Wan, Sumin Chen, Qiuyan Zhao, Tian Li, Shengzheng Luo, Xiaobo Cai, Yingchun Ren, Lanting Yu, Baiwen Li
Background/Aims: Although endoscopic metal biliary endoprosthesis (EMBE) is widely accepted as the most suitable drainage method for patients with unresectable malignant obstruction, uncontrolled post-procedural cholangitis is still a problem. We aimed to validate a new treatment modality to prevent post-ERCP cholangitis in patients with unresectable cholangiocarcinoma. Patients and Methods: A total of 378 patients who were diagnosed with unresectable malignant biliary obstruction and underwent EMBE or temporary endoscopic nasobiliary drainage (ENBD) following EMBE placement, from January 2010 to July 2016, were enrolled in this retrospective study...
July 9, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/30017329/electrochemotherapy-of-cholangiocellular-carcinoma-at-hepatic-hilum-a-feasibility-study
#8
Luciano Tarantino, Giuseppina Busto, Aurelio Nasto, Riccardo Aurelio Nasto, Paolo Tarantino, Raffaele Fristachi, Luigi Cacace, Sara Bortone
AIM: We evaluated feasibility, safety and efficacy of Electrochemotherapy (ECT) in a prospective series of patients with unresectable Perihilar-Cholangiocarcinoma (PHCCA). PATIENTS AND METHODS: Five patients with PHCCA underwent ECT. Three patients underwent percutaneous ECT of a single PHCCA nodule. One patient underwent resection of a nodule in the IV segment and intraoperative ECT of a large PHCCA in the VIII segment. Another patient underwent percutaneous ECT of a large PHCCA recurrence after left lobectomy and RF ablation of a synchronous metastasis in the VI segment...
July 6, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30003193/surgical-management-of-hilar-cholangiocarcinoma-at-memorial-sloan-kettering-cancer-center
#9
REVIEW
Michael E Lidsky, William R Jarnagin
Hilar cholangiocarcinoma, which represents approximately 60% of biliary tract malignancies, is increasing in incidence and presents an ongoing challenge for patients and hepatobiliary surgeons. Although the majority of patients present with advanced disease, the remaining minority of patients are best treated with surgical resection or transplant. Transplant is typically reserved for locally unresectable tumors often in the setting of underlying hepatic dysfunction and will not be discussed herein. This review, therefore, focuses on oncological resection and the strategies implemented for the treatment of hilar cholangiocarcinoma at a quaternary referral center, including preoperative considerations such as patient selection and optimization of the future liver remnant, nuances to the operative approach for these tumors such as resection under low central venous pressure and management of the bile duct, as well as postoperative management...
July 2018: Annals of gastroenterological surgery
https://www.readbyqxmd.com/read/29998018/chemoradiotherapy-versus-chemotherapy-alone-for-unresected-intrahepatic-cholangiocarcinoma-practice-patterns-and-outcomes-from-the-national-cancer-data-base
#10
Vivek Verma, Adams Kusi Appiah, Tim Lautenschlaeger, Sebastian Adeberg, Charles B Simone, Chi Lin
Background: Current guidelines recommend chemotherapy (CT) with or without radiotherapy (RT) for unresected intrahepatic cholangiocarcinoma (IC). Although there is currently lack of consensus, previous smaller studies have illustrated the efficacy of local therapy for this population. This investigation evaluated outcomes of chemoradiotherapy (CRT) versus CT alone in unresected IC using a large, contemporary national database. Methods: The National Cancer Data Base (NCDB) was queried for primary IC cases (2004-2013) receiving CT alone or CRT...
June 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29976141/-18-f-fdg-pet-ct-may-be-a-suitable-method-for-preoperative-diagnosis-and-evaluation-of-chinese-older-patients-with-hilar-cholangiocarcinoma
#11
Xuling Li, Ying Zhang, Yongyang Zhang
BACKGROUND: As the most common cholangiocarcinoma, hilar cholangiocarcinoma (HCCA) is a challenge in hepatobiliary surgery and causes a very poor prognosis. This study was designed to explore whether 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) may be a suitable method for preoperative diagnosis and evaluation of Chinese older patients with hilar cholangiocarcinoma. METHODS: This study enrolled 53 patients (≥ 65 years) with HCCA...
July 6, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29962728/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-imaging-of-inferior-vena-cava-tumor-thrombus-extending-into-the-right-atrium-in-a-patient-with-cholangiocarcinoma-treated-with-90-y-microspheres
#12
Luca Filippi, Annamaria Lacanfora, Roberto Cianni, Orazio Schillaci, Oreste Bagni
We present a case of a 42-year-old male patient affected by unresectable, chemorefractory cholangiocarcinoma, with prior placement of biliary stent. Because of the absence of extrahepatic metastases, he was submitted to liver-direct therapy with 90 Y-microspheres. 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) performed before the procedure showed intense tracer uptake in the hepatic lesion and along the biliary stent. The patient underwent radioembolization with 90 Y-resin spheres (1...
July 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29942151/role-of-palliative-radiotherapy-in-unresectable-intrahepatic-cholangiocarcinoma-population-based-analysis-with-propensity-score-matching
#13
Feng Shao, Wei Qi, Fu Tao Meng, Lujun Qiu, Qiang Huang
Background: This population-based study evaluated the overall (OS) and cancer-specific survival (CSS) benefit from palliative radiotherapy (RT) in patients with unresectable intrahepatic cholangiocarcinoma (ICC). Methods: We queried The Surveillance, Epidemiology, and End Results (SEER) database for the patients with unresectable ICC diagnosed from 1973 to 2013. Propensity score-matched analysis was performed to reduce the impact of the selection bias between the palliative RT group and the nonpalliative RT group...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29874985/prognostic-implications-of-hepatitis-b-virus-infection-in-intrahepatic-cholangiocarcinoma-treated-with-first-line-gemcitabine-plus-cisplatin
#14
Heejung Chae, Hyungwoo Cho, Changhoon Yoo, Kyu-Pyo Kim, Jae Ho Jeong, Heung-Moon Chang, Jihoon Kang, Han Chu Lee, Young-Suk Lim, Kang Mo Kim, Ju Hyun Shim, Sang Soo Lee, Do Hyun Park, Tae Jun Song, Shin Hwang, Gi-Won Song, Deok-Bog Moon, Young-Joo Lee, Jae Hoon Lee, Baek-Yeol Ryoo
PURPOSE: Hepatitis B virus infection is a well-known risk factor for intrahepatic cholangiocarcinoma. However, its prognostic impact has rarely been investigated in advanced intrahepatic cholangiocarcinoma. METHODS: Between April 2010 and May 2015, 296 patients with unresectable or metastatic intrahepatic cholangiocarcinoma who received gemcitabine plus cisplatin (GemCis) were categorized into a hepatitis B virus group (n=62; 21%) and a non-hepatitis B virus group (n=234; 79%)...
June 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29869103/thermal-ablation-of-intrahepatic-cholangiocarcinoma-safety-efficacy-and-factors-affecting-local-tumor-progression
#15
Edwin A Takahashi, Kristin A Kinsman, Grant D Schmit, Thomas D Atwell, John J Schmitz, Brian T Welch, Matthew R Callstrom, Jennifer R Geske, A Nicholas Kurup
PURPOSE: To evaluate the safety and oncologic efficacy of percutaneous thermal ablation of intrahepatic cholangiocarcinoma (ICC) and identify risk factors for local tumor progression (LTP). MATERIALS AND METHODS: Retrospective review of an institutional tumor ablation registry demonstrated that 20 patients (9 males, 11 females; mean age 62.5 ± 15.8 years) with 50 ICCs (mean size 1.8 ± 1.3 cm) were treated with percutaneous radiofrequency ablation (RFA) or microwave ablation (MWA) between 2006 and 2015...
June 4, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29851859/nutritional-prognostic-scores-in-patients-with-hilar-cholangiocarcinoma-treated-by-percutaneous-transhepatic-biliary-stenting-combined-with-125i-seed-intracavitary-irradiation-a-retrospective-observational-study
#16
Peiyuan Cui, Qing Pang, Yong Wang, Zhen Qian, Xiaosi Hu, Wei Wang, Zongkuang Li, Lei Zhou, Zhongran Man, Song Yang, Hao Jin, Huichun Liu
We mainly aimed to preliminarily explore the prognostic values of nutrition-based prognostic scores in patients with advanced hilar cholangiocarcinoma (HCCA).We retrospectively analyzed 73 cases of HCCA, who underwent percutaneous transhepatic biliary stenting (PTBS) combined with I seed intracavitary irradiation from November 2012 to April 2017 in our department. The postoperative changes of total bilirubin (TBIL), direct bilirubin (DBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and albumin (ALB) were observed...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29850347/cholangiocarcinoma-in-a-child-with-progressive-abdominal-distension-and-secondary-hypercalcemia
#17
Chalinee Monsereenusorn, Kantang Satayasoontorn, Piya Rujkijyanont, Chanchai Traivaree
Cholangiocarcinoma is extremely rare in childhood and has been reported in association with other underlying diseases. The survival and prognosis are dismal especially in patients with unresectable or advanced stage cholangiocarcinoma. Overall survival in patients with metastatic cholangiocarcinoma could be increased by using combination chemotherapy with cisplatin and gemcitabine. A case of childhood cholangiocarcinoma was hereby reported.
2018: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/29779953/a-quality-assurance-device-for-measuring-afterloader-performance-and-transit-dose-for-nasobiliary-high-dose-rate-brachytherapy
#18
Christopher L Deufel, John P Mullins, Mark J Zakhary
PURPOSE: Nasobiliary high-dose-rate (HDR) brachytherapy has emerged as an effective tool to boost the radiation dose for patients with unresectable perihilar cholangiocarcinoma. This work describes a quality assurance (QA) tool for measuring the HDR afterloader's performance, including the transit dose, when the source wire travels through a tortuous nasobiliary catheter path. METHODS AND MATERIALS: The nasobiliary QA device was designed to mimic the anatomical path of a nasobiliary catheter, including the nasal, stomach, duodenum, and bile duct loops...
July 2018: Brachytherapy
https://www.readbyqxmd.com/read/29735023/liver-transplant-for-cholangiocarcinoma
#19
REVIEW
Daniel Zamora-Valdes, Julie K Heimbach
Liver transplant (LT) for perihilar cholangiocarcinoma (CCA) offers an opportunity for survival among patients with early-stage but anatomically unresectable disease. The 5-year survival rate after LT is 65% to 70%, higher among patients with primary sclerosing cholangitis, who are often diagnosed earlier, and lower among patients with de novo CCA. The results of LT for hilar CCA, along with recent limited data suggesting favorable survival among patients with very early intrahepatic CCA (ICC), have reignited interest in the subject...
June 2018: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/29676221/prognostic-biomarkers-for-cholangiocarcinoma-and-their-clinical-implications
#20
Charupong Saengboonmee, Kanlayanee Sawanyawisuth, Yaovalux Chamgramol, Sopit Wongkham
Cholangiocarcinoma (CCA) is a poorly prognostic cancer with limited treatment options. Most patients have unresectable tumors when they are diagnosed and the chemotherapies provided are of limited benefit. Prognostic markers are therefore necessary to predict the disease outcome, risk of relapse, or to suggest the best treatment option. Areas covered: This article provides an up-to-date review of biomarkers with promising characteristics to be prognostic markers for CCA reported in the past 5 years. The biomarkers are sub-classified into tissue and serum markers...
June 2018: Expert Review of Anticancer Therapy
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