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Amador García-Ramos, Alejandro Pérez-Castilla, Slobodan Jaric
This study aimed to compare the reliability and validity of the force-velocity (F-V) relationship parameters obtained from two-point methods differing in the distance between experimental points, and to evaluate the acute change in unloaded jump height after a vertical jump testing procedure based on multiple loads. Totally, 18 men randomly performed two sessions of the squat jump (SJ) and two sessions of the countermovement jump (CMJ) exercises against five external loads (17, 30, 45, 60 and 75 kg). The unloaded jump height was evaluated before and after each testing procedure...
December 12, 2018: Sports Biomechanics
Gonçalo Ferreira Godinho, Alexandre Cavalheiro, Henrique Soares Luís, Rosário Mexia
The Oral Impacts on Daily Performance (OIDP) questionnaire is an oral health-related quality of life indicator. It was developed in order to assess the influence of oral conditions on the self-ability to execute daily activities. The main goal of this research was to validate the OIDP for the Portuguese population aged 18 years and above. The first step was to obtain a provisional Portuguese version of the OIDP: the original was translated from English and then back-translated. Some linguistic changes were made, and the final Portuguese version was obtained, which was duly approved by a review committee, whose members included researchers and translators...
December 2018: Ciência & Saúde Coletiva
Ifrah Alam Malik, Damayanthi Durairajanayagam, Harbindar Jeet Singh
Leptin, an adipocyte-derived hormone, serves numerous physiological functions in the body, particularly during puberty and reproduction. The exact mechanism by which leptin activates the gonadotropin-releasing hormone (GnRH) neurons to trigger puberty and reproduction remains unclear. Given the widespread distribution of leptin receptors in the body, both central and peripheral mechanisms involving the hypothalamic-pituitary-gonadal axis have been hypothesized. Leptin is necessary for normal reproductive function, but when present in excess, it can have detrimental effects on the male reproductive system...
December 11, 2018: Asian Journal of Andrology
Kelly A Devereaux, Vivek Charu, Shuchun Zhao, Gregory W Charville, Charles D Bangs, Matt van de Rijn, Athena M Cherry, Yasodha Natkunam
Undifferentiated malignancies (UMs) encompass a diverse set of aggressive tumors that pose not only a diagnostic challenge but also a challenge for clinical management. Most tumors in this category are currently treated empirically with nonspecific chemotherapeutic agents that yield extremely poor clinical response. Given that UMs are inherently genetically unstable neoplasms with the potential for immune dysregulation and increased neoantigen production, they are likely to be particularly amenable to immune checkpoint inhibitors, which target programmed cell death protein 1 (PD-1) or its ligands, PD-L1 and PD-L2, to promote T-cell antitumor activity...
December 2018: Human Pathology
Marwa Aa Ragab, Mohamed A Korany, Shereen M Galal, Aya R Ahmed
AIM: Differential pulse polarography was used for the concurrent analysis of the coadministered dantrolene (DAN) and indomethacin (IND) in plasma. MATERIALS & METHODS: DAN and IND, Hanging mercury drop electrode and Britton-Robinson buffer at pH 5 were used. In plasma, cathodic reduction of DAN nitro group and its active metabolite at -0.2 V was done. IND was analyzed after carbonyl group reduction at -1.1 V. RESULTS: Drugs determination in rat plasma with good recoveries and low limit of quantitation was done...
December 12, 2018: Bioanalysis
Jason Chen, Dat Ngo, Joseph Rosenthal
A 26-year-old male with a history of pre-B cell acute lymphoblastic leukemia and seizures presented with second relapse of acute lymphoblastic leukemia and central nervous system involvement, 19 years after the initial diagnosis. Over the next two months, the patient received six doses of triple intrathecal chemotherapy (cytarabine, methotrexate, and hydrocortisone), three concurrently with continuous blinatumomab in the second month. Approximately 12 days after blinatumomab initiation, he developed central nervous system toxicity manifesting as speech impairment, altered mental status, incontinence, and diffuse weakness...
December 11, 2018: Journal of Oncology Pharmacy Practice
Nathalie M Enk, Annette P N Kutter, Claudia Kuemmerle-Fraune, Nadja E Sigrist
BACKGROUND: Correlation of plasma fibrinogen concentration (fibrinogenClauss ) with rotational thromboelastometry (ROTEM) parameters has not been investigated in dogs. OBJECTIVES: To determine the correlation between plasma coagulation tests and fibrinogenClauss with ROTEM parameters and to evaluate their ability to predict bleeding in dogs. ANIMALS: Ninety-seven dogs with concurrent determination of fibrinogenClauss and fibrin polymerization test (FIBTEM) analysis...
December 11, 2018: Journal of Veterinary Internal Medicine
Xiao-Tao Zhou, Ze-Jin Pu, Li-Xuan Liu, Guo-Ping Li, Jia-Lin Feng, Hua-Chen Zhu, Ling-Fei Wu
In cancer research, autophagy acts as a double‑edged sword: it increases cell viability or induces cell apoptosis depending upon the cell context and functional status. Recent studies have shown that adenosine (Ado) has cytotoxic effects in many tumors. However, the role of autophagy in Ado‑induced apoptosis is still poorly understood. In the present study, Ado‑induced apoptotic death and autophagy in hepatoblastoma HepG2 cells was investigated and the relationship between autophagy and apoptosis was identified...
November 30, 2018: Oncology Reports
Praveen Pandey, Deepika Singh, Mohammad Hasanain, Raghib Ashraf, Mayank Maheshwari, Kuldeep Choyal, Akhilesh Singh, Dipak Datta, Brijesh Kumar, Jayanta Sarkar
Sphaeranthus indicus Linn. is commonly used in Indian traditional medicine for management of multiple pathological conditions. However, there are limited studies on anti-cancer activity of this plant and its underlying molecular mechanisms. Here, we isolated an active constituent, 7-hydroxyfrullanolide (7-HF), from the flowers of this plant which showed promising chemotherapeutic potential. The compound was more effective in inhibiting in vitro proliferation of colon cancers cells through G2/M phase arrest than other cancer cell lines that were used in the present study...
December 8, 2018: Carcinogenesis
T Lee Gilman, Nathan C Mitchell, Lynette C Daws, Glenn M Toney
High dietary salt intake (HDSI) increases risk of stress-related neuropsychiatric disorders. Here, we explored the contribution of HDSI-induced neuroinflammation in key stress-responsive brain regions, the hypothalamic paraventricular nucleus (PVN) and basolateral amygdala (BLA), in promoting exaggerated neuronal activation and coping behaviors in response to acute psychogenic stress. Mice that underwent HDSI exhibited increased active stress coping behaviors during and after an acute swim stress, and these were reduced by concurrent administration of minocycline, an inhibitor of microglial activation, without affecting body fluid hyperosmolality caused by HDSI...
December 8, 2018: International Journal of Neuropsychopharmacology
Maria V Stuckenberg, Chaitra V Nayak, Bernd T Meyer, Christoph Völker, Volker Hohmann, Alexandra Bendixen
Purpose: For elderly listeners, it is more challenging to listen to 1 voice surrounded by other voices than for young listeners. This could be caused by a reduced ability to use acoustic cues-such as slight differences in onset time-for the segregation of concurrent speech signals. Here, we study whether the ability to benefit from onset asynchrony differs between young (18-33 years) and elderly (55-74 years) listeners. Method: We investigated young (normal hearing, N = 20) and elderly (mildly hearing impaired, N = 26) listeners' ability to segregate 2 vowels with onset asynchronies ranging from 20 to 100 ms...
December 10, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
Vishal Kapoor, Michel Besserve, Nikos K Logothetis, Theofanis I Panagiotaropoulos
The role of lateral prefrontal cortex (LPFC) in mediating conscious perception has been recently questioned due to potential confounds resulting from the parallel operation of task related processes. We have previously demonstrated encoding of contents of visual consciousness in LPFC neurons during a no-report task involving perceptual suppression. Here, we report a separate LPFC population that exhibits task-phase related activity during the same task. The activity profile of these neurons could be captured as canonical response patterns (CRPs), with their peak amplitudes sequentially distributed across different task phases...
2018: Communications biology
Si Zhang, Junhao Hu, Weijie Fan, Bo Liu, Li Wen, Guangxian Wang, Mingfu Gong, Chunyan Yang, Dong Zhang
Background : Early postmenopausal women frequently suffer from cognitive impairments and emotional disorders, such as lack of attention, poor memory, deficits in executive function and depression. However, the underlying mechanisms of these impairments remain unclear. Method : Forty-three early postmenopausal women and forty-four age-matched premenopausal controls underwent serum sex hormone analysis, neuropsychological testing and resting-state functional magnetic resonance imaging (rs-fMRI). Degree centrality (DC) analysis was performed to confirm the peak points of the functionally abnormal brain areas as the centers of the seeds...
2018: Frontiers in Cellular Neuroscience
Joshua T Bram, Nakul S Talathi, Neeraj M Patel, Christopher J DeFrancesco, Brendan M Striano, Theodore J Ganley
OBJECTIVE: To identify associations between race or insurance status and preoperative, intraoperative, and postoperative findings in a large cohort of pediatric anterior cruciate ligament (ACL) reconstructions. DESIGN: Retrospective cohort study. SETTING: Division of Orthopaedics at an urban tertiary care children's hospital. PATIENTS: 915 pediatric (<21) patients undergoing primary ACL reconstruction between January 2009 and May 2016...
November 28, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Jon Gluyas, Lee Thompson, Dave Allen, Charlotte Benton, Paula Chadwick, Sam Clark, Joel Klinger, Vitaly Kudryavtsev, Darren Lincoln, Ben Maunder, Cathryn Mitchell, Sam Nolan, Sean Paling, Neil Spooner, Lazar Staykov, Sam Telfer, David Woodward, Max Coleman
Carbon capture and storage is a transition technology from a past and present fuelled by coal, oil and gas and a planned future dominated by renewable energy sources. The technology involves the capture of carbon dioxide emissions from fossil fuel power stations and other point sources, compression of the CO2 into a fluid, transporting it and injecting it deep beneath the Earth's surface into depleted petroleum reservoirs and other porous formations. Once injected, the CO2 must be monitored to ensure that it is emplaced and assimilated as planned and that none leaks back to surface...
December 10, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Aruljothi Mariappan, Komal Soni, Kenji Schorpp, Fan Zhao, Amin Minakar, Xiangdong Zheng, Sunit Mandad, Iris Macheleidt, Anand Ramani, Tomáš Kubelka, Maciej Dawidowski, Kristina Golfmann, Arpit Wason, Chunhua Yang, Judith Simons, Hans-Günther Schmalz, Anthony A Hyman, Ritu Aneja, Roland Ullrich, Henning Urlaub, Margarete Odenthal, Reinhardt Büttner, Haitao Li, Michael Sattler, Kamyar Hadian, Jay Gopalakrishnan
Centrosome amplification is a hallmark of human cancers that can trigger cancer cell invasion. To survive, cancer cells cluster amplified extra centrosomes and achieve pseudobipolar division. Here, we set out to prevent clustering of extra centrosomes. Tubulin, by interacting with the centrosomal protein CPAP, negatively regulates CPAP-dependent peri-centriolar material recruitment, and concurrently microtubule nucleation. Screening for compounds that perturb CPAP-tubulin interaction led to the identification of CCB02, which selectively binds at the CPAP binding site of tubulin...
December 10, 2018: EMBO Journal
Nathan Egnew, Nilima Renukdas, Yathish Ramena, Amit K Yadav, Anita M Kelly, Rebecca T Lochmann, Amit Kumar Sinha
Waterborne ammonia is an environmental pollutant that is toxic to all aquatic animals. However, ammonia induced toxicity as well as compensatory mechanisms to defend against high environmental ammonia (HEA) are not well documented at present for largemouth bass (Micropterus salmoides), a high value fish for culture and sport fisheries in the United States. To provide primary information on the sensitivity of this species to ammonia toxicity, a 96 h-LC50 test was conducted. Thereafter, responses at physiological, ion-regulatory and transcript levels were determined to get insights into the underlying adaptive strategies to ammonia toxicity...
November 30, 2018: Aquatic Toxicology
Mohamed Mahmoud El-Seweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Reham Raafat El-Zeiky, Naif A Al-Gabri
10-Dehydrogingerdione is a novel cholesteryl ester transfer protein (CETP) inhibitor of natural origin. Some synthetic CETP inhibitors have recently been reported to suppress proprotein convertase subtilisin/kexin type 9 (PCSK9). Therefore, the present study aimed mainly to clarify the effect of 10-Dehydrogingerdione on cellular adhesion inflammatory molecules, platelet activation and endothelial dysfunction markers in addition to PCSK9 as compared to atorvastatin in dyslipidemic rabbits. Dyslipidemia was induced in 30 male rabbits, distributed in 3 equal groups through feeding dietary cholesterol (0...
December 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
D J Vidyadhara, Arun Sasidharan, Bindu M Kutty, T R Raju, Phalguni Anand Alladi
Asian-Indians are less vulnerable to Parkinson's disease (PD) than the Caucasians. Their admixed populace has even lesser risk. Studying this phenomenon using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-susceptible C57BL/6J, MPTP-resistant CD-1 and their resistant crossbred mice revealed differences in the nigrostriatal cyto-molecular features. Here, we investigated the electrophysiological and behavioural correlates for differential MPTP-susceptibility and their outcome upon admixing. We recorded local field potentials (LFPs) from dorsal striatum and assessed motor co-ordination using rotarod and grip strength measures...
December 7, 2018: Behavioural Brain Research
Gloria Bua, Ilaria Conti, Elisabetta Manaresi, Phiroze Sethna, Scott Foster, Francesca Bonvicini, Giorgio Gallinella
Parvovirus B19 (B19V), a single-stranded DNA virus in the family Parvoviridae, is a human pathogenic virus responsible for a wide range of clinical manifestations. Currently there is no approved antiviral therapy for parvovirus infection. The acyclic nucleoside phosphonate cidofovir (CDV) has been demonstrated to inhibit replication of B19V in vitro. The aim of the present study was to evaluate whether brincidofovir (BCV), a novel lipid conjugate of CDV, could also inhibit B19V replication. Experiments were carried out in erythroid progenitor cells (EPCs) and UT7/EpoS1 cells, infected with B19V and cultured in the presence of different concentrations of BCV and CDV for comparison...
December 7, 2018: Antiviral Research
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