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https://www.readbyqxmd.com/read/30098435/human-placenta-simulator-for-intracranial-intracranial-bypass-vascular-anatomy-and-5-bypass-techniques
#1
Marcelo Magaldi Oliveira, Leonardo Welhinger, Jose Augusto Malheiros, Arthur Nicolato, Andre Prosdocimi, Luiza Guerra, Pollyana Hv Costa, Carlos Eduardo Ferrarez, Mauro Tostes Ferreira, Eric Sauvageau, Ricardo Hanel
BACKGROUND: Intracranial-intracranial (IC) bypass surgery involves the use of significant technical bimanual skills. Indications for this procedure are limited, so training in a simulator with brain vessels similarity could maintain micro-surgical dexterity. Our goal is to describe the human placenta vascular anatomy to guide IC-IC bypasses apprenticeship. METHODS: Human placenta vascular anatomy was reported and validated with comparison to brain main vessels after studying the vascular tree of 100 placentas...
August 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30097531/autocrine-il-10-signaling-promotes-dendritic-cell-type-2-activation-and-persistence-of-murine-cryptococcal-lung-infection
#2
Seagal Teitz-Tennenbaum, Steven P Viglianti, Jonathan A Roussey, Stuart M Levitz, Michal A Olszewski, John J Osterholzer
The substantial morbidity and mortality caused by invasive fungal pathogens, including Cryptococcus neoformans , necessitates increased understanding of protective immune responses against these infections. Our previous work using murine models of cryptococcal lung infection demonstrated that dendritic cells (DCs) orchestrate critical transitions from innate to adaptive immunity and that IL-10 signaling blockade improves fungal clearance. To further understand interrelationships among IL-10 production, fungal clearance, and the effect of IL-10 on lung DCs, we performed a comparative temporal analysis of cryptococcal lung infection in wild type C57BL/6J mice (designated IL-10+/+ ) and IL-10-/- mice inoculated intratracheally with C...
August 10, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30096988/acute-effects-of-aerobic-exercise-performed-with-different-volumes-on-strength-performance-and-neuromuscular-parameters
#3
Natalia Ribeiro, Carlos Ugrinowitsch, Valéria Leme Gonçalves Panissa, Valmor Tricoli
The aim of the present study was to investigate the acute effect of the aerobic exercise volume on maximum strength and strength-endurance performance; and possible causes of strength decrements (i.e. central and peripheral fatigue). Twenty-one moderately trained men were submitted to a maximal incremental test to determine anaerobic threshold (AnT) and maximum dynamic strength (1RM) and strength-endurance (i.e. total volume load [TV]) tests to determine their baseline strength performance. Following, subjects performed six experimental sessions: aerobic exercise sessions (continuous running at 90% AnT) with different volumes (3 km, 5 km or 7 km) followed by 1RM or strength-endurance test in the 45° leg press exercise...
August 10, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/30096586/trichoderma-harzianum-diminished-oxidative-stress-caused-by-2-4-dichlorophenoxyacetic-acid-2-4-d-in-wheat-with-insights-from-lipidomics
#4
Przemysław Bernat, Justyna Nykiel-Szymańska, Ewa Gajewska, Sylwia Różalska, Paulina Stolarek, Julia Dackowa, Mirosława Słaba
2,4-dichlorophenoxyacetic acid (2,4-D) is among the most commonly used herbicides applied for weed control during wheat cultivation. However, its application could affect wheat growth. The present study investigates the effect of the ascomycetous fungus Trichoderma harzianum on lipid peroxidation, phospholipids, signaling lipids and phospholipase D in the seedlings of wheat (Triticum aestivum L.) treated with 2,4-D (2.5 mg L-1 ). In the group of 4-day-old seedlings exposed to the herbicide, increased lipid peroxidation and inhibition of growth were observed in shoots and roots...
August 1, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/30095858/low-frequency-high-intensity-versus-medium-frequency-low-intensity-combined-therapy-in-the-management-of-active-myofascial-trigger-points-a-randomized-controlled-trial
#5
Mary Kamal Nassif Takla
BACKGROUND: Electrotherapeutic modalities have proven to be one of the best therapeutic options for myofascial pain syndrome, targeting the myofascial trigger points (MTrPs). Combined therapy (CT) is described with paucity in literature as the application of ultrasound (US) and electrical stimulating current concurrently and at the same site. AIM: The aim was to compare between low-frequency, high-intensity burst transcutaneous electrical nerve stimulation CT (burst-TENS-CT) and medium-frequency, low-intensity amplitude modulated frequency CT (AMF-CT) on upper trapezius active MTrPs (A-MTrPs)...
August 10, 2018: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
https://www.readbyqxmd.com/read/30095453/health-information-counselors-a-new-profession-for-the-age-of-big-data
#6
Amelia Fiske, Alena Buyx, Barbara Prainsack
Health care is increasingly data-driven. Concurrently, there are growing concerns that health professionals lack the time and training to guide patients through the growing medical "data jungle." In the age of big data, ever wider domains of people's lives are "datafied," which renders ever more information-at least in principle-usable for health care purposes. Turning data into meaningful information for clinical practice-and deciding what data or information should not be used for this purpose-requires a significant amount of time, resources, and skill...
August 7, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/30095301/extracellular-esterase-activity-as-an-indicator-of-endoplasmic-reticulum-calcium-depletion
#7
Kathleen A Trychta, Emily J Heathward, Agnieszka Sulima, Susanne Bäck, Mehdi Farokhnia, Christopher T Richie, Lorenzo Leggio, Kenner C Rice, Brandon K Harvey
CONTEXT: Endoplasmic reticulum (ER) calcium depletion is associated with diverse diseases, including cardiac, hepatic, and neurologic diseases. OBJECTIVE: The aim of the present study was to identify and characterize an endogenous protein that could be used to monitor ER calcium depletion comparably to a previously described exogenous reporter protein. MATERIALS AND METHODS: The use of a selective esterase-fluorescein diester pair allowed for carboxylesterase activity in extracellular fluid to be measured using a fluorescent readout...
August 10, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30094792/evaluation-of-safety-and-efficacy-of-p53mva-vaccine-combined-with-pembrolizumab-in-patients-with-advanced-solid-cancers
#8
V Chung, F J Kos, N Hardwick, Y Yuan, J Chao, D Li, J Waisman, M Li, K Zurcher, P Frankel, D J Diamond
BACKGROUND: Vaccination of cancer patients with p53-expressing modified vaccinia Ankara virus (p53MVA) has shown in our previous studies to activate p53-reactive T cells in peripheral blood but without immediate clinical benefit. We hypothesized that the immunological responses to p53MVA vaccine may require additional immune checkpoint blockade to achieve clinically beneficial levels. We therefore conducted a phase I trial evaluating the combination of p53MVA and pembrolizumab (anti-PD-1) in patients with advanced solid tumors...
August 9, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/30094621/case-control-study-of-inflammatory-bowel-disease-patients-with-and-without-clostridium-difficile-infection-and-poor-outcomes-in-patients-coinfected-with-c-difficile-and-cytomegalovirus
#9
Yue Li, Hui Xu, Tao Xu, Meng Xiao, Hao Tang, Dong Wu, Bei Tan, Ji Li, Hong Yang, Hong Lv, Yingchun Xu, Jiaming Qian
BACKGROUND AND AIMS: Clostridium difficile infection (CDI) incidence and risk factors in patients with inflammatory bowel disease (IBD) have been extensively studied. However, data describing CDI in Chinese patients with IBD are limited. We investigated the cumulative incidence, risk factors, and outcomes of CDI in Chinese IBD patients. METHODS: We conducted a retrospective, case-control study of patients hospitalized with IBD and CDI at Peking Union Medical College Hospital from January 2010 to December 2015...
August 9, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/30094509/peg10-counteracts-signaling-pathways-of-tgf-%C3%AE-and-bmp-to-regulate-growth-motility-and-invasion-of-sw1353-chondrosarcoma-cells
#10
Yuhei Yahiro, Shingo Maeda, Naohiro Shinohara, Go Jokoji, Daisuke Sakuma, Takao Setoguchi, Yasuhiro Ishidou, Satoshi Nagano, Setsuro Komiya, Noboru Taniguchi
Recently, we reported highly active transforming growth factor (TGF)-β and bone morphogenetic protein (BMP) signaling in human chondrosarcoma samples and concurrent downregulation of paternally expressed gene 10 (PEG10). PEG10 expression was suppressed by TGF-β signaling, and PEG10 interfered with the TGF-β and BMP-SMAD pathways in chondrosarcoma cells. However, the roles of PEG10 in bone tumors, including chondrosarcoma, remain unknown. Here, we report that PEG10 promotes SW1353 chondrosarcoma cell growth by preventing TGF-β1-mediated suppression...
August 9, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30094406/gut-and-liver-b-cells-of-common-clonal-origin-in-primary-sclerosing-cholangitis-inflammatory-bowel-disease
#11
Brian K Chung, Eva Kristine Klemsdal Henriksen, Kristin Kaasen Jørgensen, Tom H Karlsen, Gideon M Hirschfield, Evaggelia Liaskou
B cells express an antigen-specific B-cell receptor (BCR) and may contribute to liver inflammation by recognizing shared antigens in the gut and liver. Herein, we used high-throughput BCR sequencing of the immunoglobulin heavy chain, specifically the complementarity-determining region 3 (CDR3), to characterize the B-cell repertoire of freshly-frozen paired gut and liver tissue samples from patients with primary sclerosing cholangitis (PSC) and concurrent inflammatory bowel disease (IBD) (PSC-IBD, n = 10) and paired formalin-fixed paraffin-embedded (FFPE) tumor-adjacent normal colon and liver tissue from patients with colorectal liver metastases (controls, n = 10)...
August 2018: Hepatology Communications
https://www.readbyqxmd.com/read/30094362/mindfulness-based-training-with-transcranial-direct-current-stimulation-modulates-neuronal-resource-allocation-in-working-memory-a-randomized-pilot-study-with-a-nonequivalent-control-group
#12
Michael A Hunter, Gregory Lieberman, Brian A Coffman, Michael C Trumbo, Mikaela L Armenta, Charles S H Robinson, Matthew A Bezdek, Anthony J O'Sickey, Aaron P Jones, Victoria Romero, Seth Elkin-Frankston, Sean Gaurino, Leonard Eusebi, Eric H Schumacher, Katie Witkiewitz, Vincent P Clark
Mindfulness-based training (MBT) and transcranial electrical stimulation (TES) methods such as direct current stimulation (tDCS) have demonstrated promise for the augmentation of cognitive abilities. The current study investigated the potential compatibility of concurrent "electrical" MBT and tDCS (or eMBT) by testing its combined effects on behavioral and neurophysiological indices of working memory (WM) and attentional resource allocation. Thirty-four healthy participants were randomly assigned to either a MBT task with tDCS group (eMBT) or an active control training task with sham tDCS (Control) group...
July 2018: Heliyon
https://www.readbyqxmd.com/read/30094103/inhibition-of-atr-downregulates-pd-l1-and-sensitizes-tumor-cells-to-t-cell-mediated-killing
#13
Lin-Lin Sun, Ri-Yao Yang, Chia-Wei Li, Mei-Kuang Chen, Bin Shao, Jung-Mao Hsu, Li-Chuan Chan, Yi Yang, Jennifer L Hsu, Yun-Ju Lai, Mien-Chie Hung
The ataxia telangiectasia and Rad3-related (ATR) kinase plays a crucial role in maintaining genome stability in response to DNA damage. Once activated, ATR acts via its downstream target to arrest the cell cycle, promote DNA repair, and enhance cell survival. Therefore, ATR has become an attractive therapeutic target in cancer therapy. Multiple clinical studies have demonstrated that ATR inhibitors can sensitize cancer cells to conventional DNA damaging agents. However, the potential effects of ATR inhibitors on immune response in the tumor microenvironment, especially on the expression of immune checkpoint-related proteins, remain elusive...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30093875/measuring-intimate-partner-violence-and-traumatic-affect-development-of-vita-an-italian-scale
#14
Gina Troisi
In a global context where the percentage of women who are victim of violence is still high (World Health Organization, 2013), intimate partner violence (IPV) can be considered the most widespread form of violence against women: in such cases violent attacks are perpetuated or threatened by a partner or ex-partner within an intimate relationship, which makes its recognition more difficult. IPV requires specific tools and, although the literature has highlighted the specific role played by some emotions (such as shame, guilt, and fear) that keep women experiencing this violence in a state of passivity and confusion, to date too little attention has been given to the construction of sound instruments able to detect post-traumatic affectivity...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30093840/targeting-of-her3-with-functional-cooperative-mirnas-enhances-therapeutic-activity-in-her2-overexpressing-breast-cancer-cells
#15
Hui Lyu, Jingcao Huang, Zhimin He, Bolin Liu
Background: The HER3 receptor functions as a major cause of drug resistance in cancer treatment. It is believed that therapeutic targeting of HER3 is required to improve patient outcomes. It is not clear whether a novel strategy with two functional cooperative miRNAs would effectively inhibit erbB3 expression and potentiate the anti-proliferative/anti-survival effects of a HER2-targeted therapy (trastuzumab) and chemotherapy (paclitaxel) on HER2-overexpressing breast cancer cells. Results: Combination of miR-125a and miR-205, as compared to either miRNA alone, potently inhibited expression of HER3 in HER2-overexpressing breast cancer BT474 cells...
2018: Biological Procedures Online
https://www.readbyqxmd.com/read/30093411/ectopic-fibroblast-growth-factor-receptor-1-promotes-inflammation-by-promoting-nuclear-factor-%C3%AE%C2%BAb-signaling-in-prostate-cancer-cells
#16
Cong Wang, Yuepeng Ke, Shaoyou Liu, Sharon Pan, Ziying Liu, Hui Zhang, Zhichao Fan, Changyi Zhou, Junchen Liu, Fen Wang
Initiation of expression of fibroblast growth factor receptor 1 (FGFR1) concurrent with loss of FGFR2 expression is a well-documented event in the progression of prostate cancer (PCa). Although it is known that some FGFR isoforms confer advantages in cell proliferation and survival, the mechanism by which the subversion of different FGFR isoforms contributes to PCa progression is incompletely understood. Here, we report that fibroblast growth factor (FGF) promotes NF-κB signaling in PCa cells and that this increase is associated with FGFR1 expression...
August 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/30093163/examination-of-clinical-and-psychosocial-determinants-of-exercise-capacity-change-in-cardiac-rehabilitation
#17
Emily C Gathright, Carly M Goldstein, Eric B Loucks, Andrew M Busch, Loren Stabile, Wen-Chih Wu
PURPOSE: Most cardiac rehabilitation (CR) completers improve in multiple functional and psychosocial domains. However, not all demonstrate uniform improvement in functional indicators such as exercise capacity. This study examined baseline predictors and correlates of change in exercise capacity from CR intake to completion. METHODS: CR participants (n = 488) completed assessment of metabolic equivalents (METs) via treadmill stress test, depressive symptoms, quality of life, and social support at intake and discharge...
August 6, 2018: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/30092370/active-agents-biomaterials-and-technologies-to-improve-biolubrication-and-strengthen-soft-tissues
#18
REVIEW
Benjamin G Cooper, Catalina Bordeianu, Ara Nazarian, Brian D Snyder, Mark W Grinstaff
Normal functioning of articulating tissues is required for many physiological processes occurring across length scales from the molecular to whole organism. Lubricating biopolymers are present natively on tissue surfaces at various sites of biological articulation, including eyelid, mouth, and synovial joints. The range of operating conditions at these disparate interfaces yields a variety of tribological mechanisms through which compressive and shear forces are dissipated to protect tissues from material wear and fatigue...
July 26, 2018: Biomaterials
https://www.readbyqxmd.com/read/30090999/tandem-androgenic-and-psychological-shifts-in-male-reproductive-effort-following-a-manipulated-win-or-loss-in-a-sporting-competition
#19
Daniel P Longman, Michele K Surbey, Jay T Stock, Jonathan C K Wells
Male-male competition is involved in inter- and intrasexual selection, with both endocrine and psychological factors presumably contributing to reproductive success in human males. We examined relationships among men's naturally occurring testosterone, their self-perceived mate value (SPMV), self-esteem, sociosexuality, and expected likelihood of approaching attractive women versus situations leading to child involvement. We then monitored changes in these measures in male rowers (N = 38) from Cambridge, UK, following a manipulated "win" or "loss" as a result of an indoor rowing contest...
August 9, 2018: Human Nature: An Interdisciplinary Biosocial Perspective
https://www.readbyqxmd.com/read/30089896/textural-features-of-cervical-cancers-on-fdg-pet-ct-associate-with-survival-and-local-relapse-in-patients-treated-with-definitive-chemoradiotherapy
#20
Shang-Wen Chen, Wei-Chih Shen, Te-Chun Hsieh, Ji-An Liang, Yao-Ching Hung, Lian-Shung Yeh, Wei-Chun Chang, Wu-Chou Lin, Kuo-Yang Yen, Chia-Hung Kao
We retrospectively reviewed the records of 142 patients with stage IB-IIIB cervical cancer who underwent 18 F-FDG-PET/CT before external beam radiotherapy plus intracavitary brachytherapy and concurrent chemotherapy. The patients were divided into training and validation cohorts to confirm the reliability of predictors for recurrence. Kaplan-Meier analysis was performed and a Cox regression model was used to examine the effects of variables on overall survival (OS), progression-free survival (PFS), distant metastasis-free survival (DMFS), and pelvic relapse-free survival (PRFS)...
August 8, 2018: Scientific Reports
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