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"Exercise induced muscle damage"

Henning Wackerhage, Brad J Schoenfeld, D Lee Hamilton, Maarit Lehti, Juha J Hulmi
One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that occurs in response to resistance exercise. A large body of work shows that a mTORC1-mediated increase of muscle protein synthesis is the key, but not sole, mechanism by which resistance exercise causes muscle hypertrophy. Whilst much of the hypertrophy signaling cascade has been identified, the initiating, resistance exercise-induced and hypertrophy-stimulating stimuli have remained elusive. For the purpose of this review, we define an initiating, resistance exercise-induced and hypertrophy-stimulating signal as "hypertrophy stimulus", and the sensor of such a signal as "hypertrophy sensor"...
October 18, 2018: Journal of Applied Physiology
Alan B Vasconcelos, Fernando K Nampo, Júlio C Molina, Miriam B Silva, Alan S Oliveira, Tarlyson R de Angelis, Amanda L Hasuda, Enilton A Camargo, Solange P Ramos
We compared the acute effects of different doses of 630 nm light-emitting diode therapy (LEDT) on skeletal muscle inflammation and hyperalgesia in rats submitted to exercise-induced muscle damage (EIMD). Wistar rats were divided into five experimental groups (n = 5-8/group): sedentary control (CON); exercise + passive recovery (PR); and exercise + LEDT (1.2 J/cm2 , 1.8 J; 4.2 J/cm2 , 6.3 J; 10.0 J/cm2 , 15 J). After 100 min of swimming, the rats in the LEDT groups were exposed to phototherapy on the triceps surae muscle...
October 17, 2018: Lasers in Medical Science
Juan Del Coso, Danielle Hiam, Peter Houweling, Laura M Pérez, Nir Eynon, Alejandro Lucía
A common null polymorphism (rs1815739; R577X) in the gene that codes for α-actinin-3 (ACTN3) has been related to different aspects of exercise performance. Individuals who are homozygous for the X allele are unable to express the α-actinin-3 protein in the muscle as opposed to those with the RX or RR genotype. α-actinin-3 deficiency in the muscle does not result in any disease. However, the different ACTN3 genotypes can modify the functioning of skeletal muscle during exercise through structural, metabolic or signaling changes, as shown in both humans and in the mouse model...
October 16, 2018: European Journal of Applied Physiology
A B V Furtado, D D Hartmann, R P Martins, P C Rosa, I K da Silva, B S L Duarte, L U Signori, F A A Soares, G O Puntel
When exercises are done in intense or exhaustive modes, several acute biochemical mechanisms are triggered. The use of cryotherapy as cold-water immersion is largely used to accelerate the process of muscular recovery based on its anti-inflammatory and analgesic properties. The present study aimed to study the biochemical effects of cold-water immersion treatment in mice submitted to exercise-induced exhaustion. Swiss albino mice were divided into 4 treatment groups: control, cold-water immersion (CWI), swimming exhaustive protocol (SEP), and SEP+CWI...
October 4, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Jozo Grgic, Pavle Mikulic, Brad J Schoenfeld, David J Bishop, Zeljko Pedisic
This paper aims to critically evaluate and thoroughly discuss the evidence on the topic of caffeine supplementation when performing resistance exercise, as well as provide practical guidelines for the ingestion of caffeine prior to resistance exercise. Based on the current evidence, it seems that caffeine increases both maximal strength and muscular endurance. Furthermore, power appears to be enhanced with caffeine supplementation, although this effect might, to a certain extent, be caffeine dose- and external load-dependent...
October 8, 2018: Sports Medicine
Razieh Nasrabadi, Zahra Izanloo, Ali Sharifnezad, Mohammad Reza Hamedinia, Nosratollah Hedayatpour
Change in muscle fiber conduction velocity (MFCV) has been reported after eccentric exercise induces muscle fiber damage, most likely due to a change in membrane permeability of the injured fiber. The extent of damage to the muscle fiber depends on the morphological and architectural characteristics of the muscle fibers. Morphological and architectural characteristics of the VMO muscle fibers are different from VL muscle. Thus, it is expected that eccentric exercise of quadriceps muscle results in a non-uniform fiber damage within the VMO and VL muscle and, as a consequence, non-uniform changes in membrane excitability and conduction velocity...
June 18, 2018: Journal of Electromyography and Kinesiology
Takuji Kawamura, Katsuhiko Suzuki, Masaki Takahashi, Miki Tomari, Reira Hara, Yuko Gando, Isao Muraoka
The purpose of this study was to investigate the involvement of neutrophil dynamics and function in exercise-induced muscle damage (EIMD) and delayed-onset muscle soreness (DOMS), and the effect of molecular hydrogen (H₂) intake on these parameters. Nine healthy and active young men performed H₂ and placebo bath trial in a crossover design. They carried out downhill running (-8% slope) for 30 min at a speed corresponding to 75~85% of peak oxygen uptake (VO₂peak). Subsequently, they repeated bathing for 20 min per day for one week...
September 25, 2018: Antioxidants (Basel, Switzerland)
Nicole C Dabbs, Harish Chander
The purpose of this investigation is to determine the effects of exercise induced muscle damage (EIMD) on balance and knee joint torque. Thirteen males and females volunteered to participate in the study. Following a familiarization session, baseline measures were obtained for isometric torque measured during a maximal voluntary isometric contraction (MVIC) for knee flexors and extensors, and ankle dorsi-flexors and plantar-flexors. Additionally, balance performance was tested in double leg (DL), and right single leg (RSL) static and dynamic unstable stability was measured...
September 19, 2018: Sports
Danguole Satkunskiene, Aivaras Ratkevicius, Sigitas Kamandulis, Tomas Venckunas
The aim of the present study was to investigate how myostatin dysfunction affects fast and slow muscle stiffness and viscosity during severe repeated loading. METHODS: Isolated extensor digitorum longus (EDL) and soleus muscles of young adult female mice of the BEH (dysfunctional myostatin) and BEH+/+ (functional myostatin) strains were subjected to 100 subsequent contraction-stretching loading cycles during which contractile and mechanical properties were assessed. BEH mice exhibited greater exercise-induced muscle damage, although the effect was muscle- and age-dependent and limited to the early phases of simulated exercise...
September 17, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Jason A C Lovett, Peter J Durcan, Kathryn H Myburgh
Background: Extracellular vesicles (EVs) are nano-sized vesicles that are known to be powerful mediators of intercellular communication via their microRNA (miR) content. A paucity of information on EV-mediated communication arising from skeletal muscle (SkM) in response to exercise-induced muscle damage is present in the published literature. Lack of such information inhibits our understanding of muscle injury and repair processes. Aims: To assess circulating EV levels and selected miR content within them, in response to two consecutive bouts of muscle-damaging exercise...
2018: Frontiers in Physiology
D Jason Gillis, Aurora Vellante, Joseph A Gallo, Anthony P DʼAmico
Gillis, DJ, Vellante, A, Gallo, JA, and D'Amico, AP. Influence of menthol on recovery from exercise-induced muscle damage. J Strength Cond Res XX(X): 000-000, 2018-This study assessed the influence of menthol, a cold receptor agonist, on recovery from exercise-induced muscle damage (EIMD). Forty-seven healthy males were allocated to a Control (CON, n = 18), Placebo (P, n = 14), or 4.0% Menthol (M, n = 15) condition. Participants were familiarized with a testing battery (TB) including: perception of lower-body muscle soreness, hip flexion/abduction range of motion, vertical jump (VJ), and the agility T-test...
August 29, 2018: Journal of Strength and Conditioning Research
Yoshifumi Tsuchiya, Sahiro Mizuno, Kazushige Goto
PURPOSE: To determine the effects of exercise-induced muscle damage, we examined irisin responses during level running (LR), with less muscle damage, and downhill running (DHR), with greater muscle damage under equivalent exercise duration and oxygen consumption (⩒O2) conditions. METHODS: Fifteen healthy men (age: 21.6 ± 2.0 y, height: 170 ± 1.3 cm, weight: 64.8 ± 2.7 kg) were randomly assigned to either the LR group (n = 8) or the DHR group (n = 7). Subjects in the LR group performed treadmill running at 70% of maximum oxygen uptake (⩒O2max) for 30 min on a 0% gradient...
June 30, 2018: Journal of Exercise Nutrition & Biochemistry
Fábio C Karasiak, Luiz Guilherme A Guglielmo
Karasiak, FC and Guglielmo, LGA. Effects of exercise-induced muscle damage in well-trained cyclists' aerobic and anaerobic performances. J Strength Cond Res 32(9): 2632-2640, 2018-The purpose of this study was to analyze the effect of exercise-induced muscle damage (EIMD) in gross efficiency and in aerobic and anaerobic cycling performances. Nine well-trained cyclists (30.8 ± 6.4 years, cycling experience 8.4 ± 5.6 years) visited the laboratory 5 times. During the first visit, they performed a maximal incremental test on a cycle ergometer, to identify V[Combining Dot Above]O2max (55...
September 2018: Journal of Strength and Conditioning Research
Chun-Chung Chou, Yu-Chi Sung, Glen Davison, Chung-Yu Chen, Yi-Hung Liao
Background: Exercise-induced muscle damage during intensive sport events is a very common issue in sport medicine. Therefore, the purpose is to investigate the effects of short-term high-dose vitamin C and E supplementation on muscle damage, hemolysis, and inflammatory responses to simulated competitive Olympic Taekwondo (TKD) matches in elite athletes. Methods: Using a randomized placebo-controlled and double-blind study design, eighteen elite male TKD athletes were weight-matched and randomly assigned into either a vitamin C and E group (Vit C+E; N = 9) or placebo group (PLA; N = 9)...
2018: International Journal of Medical Sciences
Daniel J Owens, Craig Twist, James N Cobley, Glyn Howatson, Graeme L Close
Exercise-induced muscle damage (EIMD) is characterized by symptoms that present both immediately and for up to 14 days after the initial exercise bout. The main consequence of EIMD for the athlete is the loss of skeletal muscle function and soreness. As such, numerous nutrients and functional foods have been examined for their potential to ameliorate the effects of EIMD and accelerate recovery, which is the purpose of many nutritional strategies for the athlete. However, the trade-off between recovery and adaptation is rarely considered...
August 15, 2018: European Journal of Sport Science
Luciano Ramos, Rodrigo Labat Marcos, Romildo Torres-Silva, Rodney Capp Pallota, Tatiana Magacho, Fernando Francisco Pazello Mafra, Michel Monteiro Macedo, Rodrigo Leal de Paiva Carvalho, Jan Magnus Bjordal, Rodrigo Alvaro B Lopes-Martins
BACKGROUND: Unusual and exhaustive physical exercise can lead to muscle lesions depending on the type of contraction, intensity, duration, age, and level of conditioning. Different therapies have been proposed to prevent or reduce exercise-induced muscle damage. OBJECTIVE: In this study, we investigate the effects of low-level laser therapy on skeletal muscle strain in an experimental model in rats. MATERIALS AND METHODS: Male Wistar rats (200 g) were used...
September 2018: Photomedicine and Laser Surgery
Z Xia, J M Cholewa, D Dardevet, T Huang, Y Zhao, H Shang, Y Yang, X Ding, C Zhang, H Wang, S Liu, Q Su, N E Zanchi
The positive influence of animal-based protein supplementation during muscle-damaging exercise has been widely studied. However, the effects of plant-based proteins remain unclear and require further clarification. This study investigated the protective role of oat protein against exercise induced muscle damage (EIMD), subsequent inflammation, and loss of performance induced by downhill running. Subjects consumed either oat protein (25 g protein) or a placebo for 14 days prior to a downhill running test and then for 4 days thereafter...
September 19, 2018: Food & Function
Meghan A Brown, Emma J Stevenson, Glyn Howatson
Tart Montmorency cherry concentrate (MC) has been reported to attenuate the symptoms of exercise-induced muscle damage (EIMD) and to accelerate exercise recovery, which has been attributed to its high anti-inflammatory and antioxidant properties. Although these data are promising, there are no data regarding exclusively female populations. Therefore, the aim of this investigation was to examine the efficacy of MC on recovery following EIMD in females. In a randomised, double-blind, placebo-controlled study, twenty physically active females (mean ± SD age 19 ± 1 y; stature 167 ± 6 cm; body mass 61...
July 28, 2018: European Journal of Sport Science
Hyun-Jun Jang, Jung Dae Lee, Hyun-Sik Jeon, Ah-Ram Kim, Suhkmann Kim, Ho-Seong Lee, Kyu-Bong Kim
Skeletal muscle can be ultrastructurally damaged by eccentric exercise, and the damage causes metabolic disruption in muscle. This study aimed to determine changes in the metabolomic patterns in urine and metabolomic markers in muscle damage after eccentric exercise. Five men and 6 women aged 19~23 years performed 30 min of the bench step exercise at 70 steps per min at a determined step height of 110% of the lower leg length, and stepping frequency at 15 cycles per min. 1 H NMR spectral analysis was performed in urine collected from all participants before and after eccentric exercise-induced muscle damage conventionally determined using a visual analogue scale (VAS) and maximal voluntary contraction (MVC)...
July 2018: Toxicological Research
Angelina Freitas Siqueira, Amilton Vieira, Martim Bottaro, João Batista Ferreira-Júnior, Otávio de Toledo Nóbrega, Vinícius Carolino de Souza, Rita de Cássia Marqueti, Nicolas Babault, João Luiz Quagliotti Durigan
The aim of this study was to investigate the effects of multiple cold-water immersions (CWIs) on muscle function, markers of muscle damage, systemic inflammation and ECM degradation following exercise-induced muscle damage (EIMD). Thirty physically active males were randomly assigned to either a control (n = 15) or cold-water immersion (CWI) group (n = 15). The CWI group performed one immersion (10 °C for 20 min) at post-exercise and every 24 h for the following 72 h, while the control group remained in a seated position during these corresponding periods...
July 19, 2018: Scientific Reports
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