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(Muscle) AND (Hypertrophy or growth or gain or accumulation)

Kyu Yun Jang, Ho Sung Park, Kyoung Min Kim, Ho Lee, Chan Young Kim
Plexiform fibromyxoma of the stomach is a very rare mesenchymal tumor found exclusively in the antrum or pylorus and characterized by plexiform growth pattern and abundant myxoid/fibromyxoid stroma. We present both cytological and histological features of gastric plexiform fibromyxoma in a 47-year-old woman. Cytological smears revealed moderate cellularity with loose clusters consisted of spindle cells, which were arranged in no specific pattern, abundant myxoid stroma as well as thin-walled blood vessels. The spindle cells revealed minimal pleomorphism and had scant cytoplasm and slender nuclei with fine chromatin and indistinct nucleoli...
August 13, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Yilin Shu, Jinquan Xia, Qiang Yu, Gang Wang, Jihui Zhang, Jun He, Huan Wang, Ling Zhang, Hailong Wu
The Chinese concave-eared torrent frog (Odorrana tormota) is the first known non-mammalian vertebrate that can communicate using ultrasound. In this species, females are approximately four times as large as males, in which the female growth rate is obviously higher than that of male. Until now, the molecular mechanisms underlying muscle growth development differences between male and female frogs have not been reported. Here, we integrated mRNA and miRNA expression profiles to reveal growth differences in the hindlimb muscles of 2-year-old frogs...
August 10, 2018: Gene
Tommy R Lundberg, Glyn Howatson
Over-the-counter analgesics, such as anti-inflammatory drugs (NSAIDs) and paracetamol, are widely consumed by athletes worldwide to increase pain tolerance, or dampen pain and reduce inflammation from injuries. Given that these drugs also can modulate tissue protein turnover, it is important to scrutinize the implications of acute and chronic use of these drugs in relation to exercise performance and the development of long-term training adaptations. In this review we aim to provide an overview of the studies investigating the effects of analgesic drugs on exercise performance and training adaptations relevant for athletic development...
August 13, 2018: Scandinavian Journal of Medicine & Science in Sports
Margreet R de Vries, Laura Parma, Erna A B Peters, Abbey Schepers, Jaap F Hamming, J Wouter Jukema, Marie-José Goumans, Liang Guo, Aloke V Finn, Renu Virmani, C Keith Ozaki, Paul H A Quax
BACKGROUND: Plaque angiogenesis is associated with atherosclerotic lesion growth, plaque instability and negative clinical outcome. Plaque angiogenesis is a natural occurring process to fulfill the increasing demand of oxygen and nourishment of the vessel wall. However, inadequate formed, immature plaque neovessels are leaky and cause intraplaque hemorrhage. OBJECTIVE: Blockade of VEGFR2 normalizes the unbridled process of plaque neovessel formation and induces maturation of nascent vessels resulting in prevention of intraplaque hemorrhage and influx of inflammatory cells into the plaque and subsequently increases plaque stability...
August 13, 2018: Journal of Internal Medicine
Filipe J Teixeira, Catarina N Matias, Cristina P Monteiro, Maria J Valamatos, Joana Reis, Francisco Tavares, Ana Batista, Christophe Domingos, Francisco Alves, Luís B Sardinha, Stuart M Phillips
Leucine metabolites, α-hydroxyisocaproic acid (α-HICA) and β-hydroxy-β-methylbutyrate (calcium, HMB-Ca and free acid, HMB-FA), have been proposed to augment resistance training-induced changes in body composition and performance. PURPOSE: We aimed to conduct a double-blind randomized controlled pragmatic trial to evaluate the effects of off-the-shelf leucine metabolite supplements of α-HICA, HMB-FA and HMB-Ca, on resistance training-induced changes in muscle thickness, and performance...
August 10, 2018: Medicine and Science in Sports and Exercise
Ryo Sasaki, Yasuyuki Ohta, Yuto Yamada, Koh Tadokoro, Yoshiaki Takahashi, Kota Sato, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Takao Yasuhara, Isao Date, Shuntaro Ikegawa, Nobuharu Fujii, Koji Abe
Neurolymphomatosis is a rare form of extranodal malignant lymphoma defined as the infiltration of malignant lymphocytes into the central or peripheral nerve. We herein report a case of neurolymphomatosis in the cauda equina diagnosed by an open surgical biopsy. He presented with muscle weakness, atrophy, numbness and hypoesthesia in the bilateral lower extremities with the accumulation of 18 fluoro-2-deoxyglucose (FDG) in the bilateral cauda equina. Cerebrospinal fluid (CSF) cytology (three times) and flow cytometry (two times) and biopsies of the left sural nerve, bone marrow, paranasal sinus and left testis were all negative for malignancy, so finally we performed a surgical open biopsy of the cauda equina by laminectomy and diagnosed him with diffuse large B-cell lymphoma (DLBCL) in the cauda equina...
August 10, 2018: Internal Medicine
Yoshiro Onoue, Yasuhiro Izumiya, Shinsuke Hanatani, Toshifumi Ishida, Yuichiro Arima, Satoru Yamamura, Yuichi Kimura, Satoshi Araki, Masanobu Ishii, Taishi Nakamura, Yu Oimatsu, Kenji Sakamoto, Eiichiro Yamamoto, Sunao Kojima, Koichi Kaikita, Kenichi Tsujita
BACKGROUND: Resistance exercise has beneficial effects for patients with peripheral arterial diseases. The hypothesis that muscle growth promotes angiogenesis by interacting with neighboring cells in ischemic lesions was assessed.Methods and Results:Skeletal muscle-specific inducible Akt1 transgenic (Akt1-TG) mice that induce growth of functional skeletal muscles as a model of resistance training were used. Proteomics analysis identified significant upregulation of heme oxigenase-1 (HO-1) in muscle tissue in Akt1-TG mice compared with control mice...
August 10, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Marta Michalik, Katarzyna Wójcik-Pszczoła, Milena Paw, Dawid Wnuk, Paulina Koczurkiewicz, Marek Sanak, Elżbieta Pękala, Zbigniew Madeja
Bronchial asthma is a chronic inflammatory disease in which bronchial wall remodelling plays a significant role. This phenomenon is related to enhanced proliferation of airway smooth muscle cells, elevated extracellular matrix protein secretion and an increased number of myofibroblasts. Phenotypic fibroblast-to-myofibroblast transition represents one of the primary mechanisms by which myofibroblasts arise in fibrotic lung tissue. Fibroblast-to-myofibroblast transition requires a combination of several types of factors, the most important of which are divided into humoural and mechanical factors, as well as certain extracellular matrix proteins...
August 12, 2018: Cellular and Molecular Life Sciences: CMLS
Matthew L Livingston, C Landon, H J Barnes, J Brake
The effects of time-limited feeding, genetic background, and egg storage on white striping (WS) and wooden breast (WB) in broilers were studied. Male chicks (240) from 2 genetic backgrounds and 2 egg storage periods were fed on either an ad libitum (AL) or time-limited (TL) program from 7 d of age. A rapid growth strain (Growth) and an enhanced yield strain (Yield) of broiler breeder males were mated to a single female line and eggs were stored for periods of either 1 to 7 d or 8 to 14 d. Body weight (BW), feed consumption, and feed conversion ratio (FCR) were determined weekly...
August 7, 2018: Poultry Science
Karin J C Sanders, Karin Klooster, Lowie E G W Vanfleteren, Dirk-Jan Slebos, Annemie M W J Schols
Muscle wasting frequently occurs in severe emphysema. Improving respiratory mechanics by bronchoscopic lung volume reduction using endobronchial valves (EBV) might prevent further loss or even increase in muscle mass. CT-derived skeletal muscle mass gain was observed in 39/49 patients 6 months after EBV. Multiple linear regression showed that gain in muscle (β=2.4; 95% CI 0.2 to 4.6; p=0.036) and intramuscular fat (β=3.1; 95% CI 0.2 to 5.9; p=0.035) is associated with improved 6 min walk distance independent of the change in residual volume...
August 12, 2018: Thorax
Luiz Alfredo Braun Ferreira, Veronica Cimolin, Hugo Pasini Neto, Luanda André Colange Grecco, Roberta Delasta Lazzari, Arislander Jonathan Lopes Dumont, Manuela Galli, Claudia Santos Oliveira
INTRODUCTION: Recovering the ability to walk is an important goal of physical therapy for patients who have survived cerebrovascular accident (stroke). Orthotics can provide a reduction in plantar flexion of the ankle, leading to greater stability in the stance phase of the gait cycle. Postural insoles can be used to reorganize the tone of muscle chains, which exerts an influence on postural control through correction reflexes. The aim of the present study was to perform kinematic and spatiotemporal analyses of gait in stroke survivors with hemiparesis during postural insole usage...
July 2018: Journal of Bodywork and Movement Therapies
Sofia Shaikh, Jessica L Waxler, Hang Lee, Kathy Grinke, Jamie Garry, Barbara R Pober, Takara L Stanley
OBJECTIVE: We assessed body composition, bone mineral density (BMD), glucose, and lipids in Williams syndrome (WS), a rare microdeletion disorder. DESIGN: Individuals with WS had outpatient assessment at Massachusetts General Hospital. Controls were selected from the National Health and Nutrition Examination Survey (NHANES 2005-2006). PATIENTS: 22 individuals with WS, each matched by age, sex, and race to 4 NHANES controls. MEASUREMENTS: Blood sampling, oral glucose tolerance test, dual energy x-ray absorptiometry (DXA) scan...
August 12, 2018: Clinical Endocrinology
Hojun Lee, Kijeong Kim, Boa Kim, Junchul Shin, Sudarsan Rajan, Jingwei Wu, Xiongwen Chen, Michael D Brown, Sukho Lee, Joon-Young Park
KEY POINTS: Referring to the muscle memory theory, previously trained muscles acquire strength and volume much faster than naive muscles. Using extreme experimental models such as synergist ablation or steroid administration, previous studies have demonstrated that the number of nuclei increases when a muscle becomes enlarged, which serves as a cellular muscle memory mechanism for the muscle. In the present study, we found that, when rats were subjected to physiologically relevant resistance training, the number of myonuclei increased and was retained during a long-term detraining period...
August 12, 2018: Journal of Physiology
Min Jin, Jia Xiong, Qi-Cun Zhou, Ye Yuan, Xue-Xi Wang, Peng Sun
An 8-week feeding trial was conducted to evaluate the effects of dietary yeast hydrolysate and brewer's yeast supplementation on growth, immune-related genes expression and ammonia nitrogen stress resistance of Pacific white shrimp (Litopenaeus vannamei). Three isonitrogenous and isolipidic practical diets were formulated to contain 0% (control diet), 1% yeast hydrolysate and 1% brewer's yeast, respectively. 360 juvenile L. vannamei with an initial weight (0.88 ± 0.01 g) was randomly divided into 3 treatments in four replicates (30 shrimp per replicate)...
August 9, 2018: Fish & Shellfish Immunology
Jia-Wei Xu, Li Zheng, Li-Juan Li, Yu-Fei Yao, He Hua, Shi-Zhen Yang, Yi-Fan Wen, Cheng-Chuang Song, Xiu-Kai Cao, Kun-Peng Liu, Gui-Min Zhang, Jia-Meng Yang, Dan Hao, Rui-Hua Dang, Xian-Yong Lan, Chu-Zhao Lei, Xing-Lei Qi, Hong Chen, Yong-Zhen Huang
Copy number variation (CNV) related to complex traits, such as disease and quantitative phenotype, is considered an important and wealthy source of genetic and phenotypic diversity. It suggests that the copy number variation of function gene maybe leads to the phenotypic changes. Kupple like factor 3 (KLF3) gene is a vital transcription factor associated with the growth and development of muscle and adipose tissue. It has been mapped in a CNV region by animal genome re-sequencing. In this study, we detected the distribution diversity of KLF3 gene copy numbers in six Chinese cattle breeds (QC, NY, XN, PN, QDM and JX) and associated the phenotypic traits with it...
August 9, 2018: Gene
Wei Wei, Hai-Yang Zhang, Xin-Kou Gong, Zhuo Dong, Zhi-Yuan Chen, Rui Wang, Jun-Xuan Yi, Yan-Nan Shen, Shun-Zi Jin
OBJECTIVE: To investigate the regulatory mechanism of MEN1 gene in radiation-induced lung fibrosis in mice and provide a new theoretical basis for the clinical treatment of radiation pulmonary fibrosis. METHODS: First, 80 C57BL/6 mice aged 8 weeks and weighing 18-22 g were selected, half of them were male and the other half were female. The mice were divided into control group and irradiation group (40 mice in each group) according to the method of the random number table...
August 9, 2018: Gene
Cid André Fidelis de Paula Gomes, Almir Vieira Dibai-Filho, Fabiano Politti, Tabajara de Oliveira Gonzalez, Daniela Aparecida Biasotto-Gonzalez
OBJECTIVE: The purpose of this study was to evaluate the effect of combined manual therapy (MT) and diadynamic (DD) currents on myofascial trigger points of the upper trapezius muscle in individuals with a diagnosis of unilateral shoulder impingement syndrome. METHODS: A randomized clinical trial was conducted involving 60 individuals with shoulder impingement syndrome who were allocated to the following 3 groups: (1) MT and DD currents (MTDD), (2) MT alone, and (3) DD currents alone...
August 8, 2018: Journal of Manipulative and Physiological Therapeutics
Chong Zhang, Xue-Qi Liu, Hao-Nan Sun, Xiao-Ming Meng, Ya-Wei Bao, Hui-Ping Zhang, Fa-Ming Pan, Chao Zhang
Fibrosis is the common results from an excessive wound-healing response to chronic liver injury. Otreotide (OCT), an analogue of somatostatin, was reported to have an anti-hepatic fibrosis effect. However, its anti-fibrosis mechanisms have not been well characterized to date. The present study aimed to investigate the protective effects of OCT on carbon tetrachloride (CCl4 )-induced rat liver fibrosis and activation and proliferation of transforming growth factor-β1 (TGF-β1)-treated hepatic stellate cells (HSCs) and explore its anti-hepatofibrotic mechanisms...
August 8, 2018: International Immunopharmacology
Callum J Donaldson, Ka Hou Lao, Lingfang Zeng
Atherosclerosis, a chronic inflammatory condition that is characterized by the accumulation of lipid-loaded macrophages, occurs preferentially at the arterial branching points where disturbed flow is prominent. The pathogenesis of atherosclerotic lesion formation is a multistage process involving multiple cell types, inflammatory mediators and hemodynamic forces in the vessel wall in response to atherogenic stimuli. Researches from the past decade have uncovered the critical roles of microRNAs (miRNAs) in regulating multiple pathophysiological effects and signaling pathways in endothelial cells (ECs), vascular smooth muscle cells (VSMCs), macrophages and lipid homeostasis, which are key in atherosclerotic lesion formation...
August 8, 2018: Journal of Molecular and Cellular Cardiology
Michael G Watson, Helen M Byrne, Charlie Macaskill, Mary R Myerscough
Atherosclerotic plaque growth is characterised by chronic, non-resolving inflammation that promotes the accumulation of cellular debris and extracellular fat in the inner artery wall. This material is highly thrombogenic, and plaque rupture can lead to the formation of blood clots that occlude major arteries and cause myocardial infarction or stroke. In advanced plaques, vascular smooth muscle cells (SMCs) are recruited from deeper in the artery wall to synthesise a cap of fibrous tissue that stabilises the plaque and sequesters the thrombogenic plaque content from the bloodstream...
August 8, 2018: Journal of Theoretical Biology
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