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https://www.readbyqxmd.com/read/28647983/-spectrum-and-case-fatality-of-inpatients-with-malignant-tumors-from-1995-to-2014-in-shenzhen-city
#1
X B Wang, L C Hong, Y Z Wei, X Fu, X Q Bao, J Zhang, G Hu, S H Wu, J Q Cheng
Objective: To analyze the epidemiological features, spectrum and case fatality of malignant tumor patients in Shenzhen city, to provide evidence for the development of prevention and treatment strategies on malignant tumor in Shenzhen. Methods: All the hospitalized malignant tumor patients including deaths, were monitored from 1995 to 2014 in Shenzhen, and data was analyzed by SPSS 20.0 software. Results: There were 160 988 inpatients of malignant tumors between 1995 and 2014 in Shenzhen. The top three hospitalized tumors were lung (13...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28643978/-diagnosis-and-management-of-gastro-esophageal-junction-tumor
#2
Mickael Chevallay, Minoa Jung, Nadja Niclauss, Philippe Morel, Stefan Mönig
At the border between the esophagus and the stomach, gastro-esophageal junction tumors require a specific management that cannot be simplified to either of these two organs. Staging work-up with endoscopy, CT-Scan and PET-Scan, is essential because it will condition the choice of neo-adjuvant treatment. Surgery remains the only curative treatment and should be undergone in specialized center.
June 14, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28639576/laparoscopic-versus-open-resection-of-small-bowel-gastrointestinal-stromal-tumors-systematic-review-and-meta-analysis
#3
Ke Chen, Bin Zhang, Yue-Long Liang, Lin Ji, Shun-Jie Xia, Yu Pan, Xue-Yong Zheng, Xian-Fa Wang, Xiu-Jun Cai
BACKGROUND: Laparoscopic resection (LAP) for small bowel gastrointestinal stromal tumors (GISTs) is not as common as for stomach. This study aimed to evaluate the safety and efficacy of LAP for small bowel GISTs with systematic review and meta-analysis. METHODS: The Web of Science, Cochrane Library, Embase, and PubMed databases before December 2016 were comprehensively searched to retrieve comparative trials of LAP and conventional open resection (OPEN) for GISTs of small bowel with a relevance of review object...
July 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28637502/clinicopathologic-characteristics-and-prognosis-of-gastroenteropancreatic-neuroendocrine-neoplasms-a-multicenter-study-in-south-china
#4
Cheng Fang, Wei Wang, Yu Zhang, Xingyu Feng, Jian Sun, Yujie Zeng, Ye Chen, Yong Li, Minhu Chen, Zhiwei Zhou, Jie Chen
BACKGROUND: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a heterogeneous group of rare tumors. Many issues in terms of epidemiologic features, pathogenesis, and treatment of GEP-NENs are still under discussion. Our study aimed to analyze the clinicopathologic characteristics and prognosis of Chinese patients with GEP-NENs. METHODS: Complete clinicopathologic data and survival information of 1183 patients with GEP-NENs treated between 2005 and 2015 were collected from five medical centers in Guangdong Province, China...
June 21, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28633616/sclerosing-stromal-tumor-mimicking-a-pregnancy-luteoma-case-report-of-a-diagnostically-challenging-entity-further-complicated-by-the-presence-of-metastatic-signet-ring-cell-carcinoma-from-the-stomach
#5
Meral Uner, Alp Usubutun
Sclerosing stromal tumors of the ovary are very rare. We report the case of a 29-year-old pregnant woman who presented with a history of preterm labor and gestational hypertension. A huge mass measuring 30 cm in greatest dimension was recognized on the right ovary during cesarean section. Signet ring cell infiltration was seen during intraoperative frozen section consultation. She underwent a right salpingo-oophorectomy, and the permanent diagnosis was sclerosing stromal tumor infiltrated by signet ring cells...
June 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28626260/a-case-of-api2-malt1-positive-gastric-malt-lymphoma-with-concomitant-diffuse-large-b-cell-lymphoma
#6
Akashi Fujita, Masahiro Tajika, Tsutomu Tanaka, Makoto Ishihara, Yutaka Hirayama, Nobumasa Mizuno, Kazuo Hara, Susumu Hijioka, Hiroshi Imaoka, Tsukasa Yoshida, Nozomi Okuno, Nobuhiro Hieda, Takashi Hirayama, Hitoshi Shibuya, Hisashi Kondo, Hirotaka Suzuki, Kazuhiro Toriyama, Yasushi Yatabe, Kenji Yamao, Yasumasa Niwa
API2-MALT1 translocation-positive gastric marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) lymphoma is thought to transform to diffuse large B-cell lymphoma (DLBCL) rarely. A 69-year-old man presented with epigastralgia. Esophagogastroduodenoscopy showed multiple ulcerations in the stomach. Endoscopic biopsies revealed MALT lymphoma, with Helicobacter pylori infection. The patient underwent eradication therapy with no improvement, and was thereafter followed without additional therapy at his request...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28616770/protective-effect-of-origanum-oil-on-alterations-of-some-trace-elements-and-antioxidant-levels-induced-by-mercuric-chloride-in-male-rats
#7
Naglaa El-Shahat Mohamed
In the current study, 48 male rats were classified into four groups (12 rats/group): 1-control group received 1 ml distilled water, 2-origanum oil group treated daily with oral dose of origanum oil (5 mg/kg) for 30 and 60 days, 3-mercuric chloride group treated daily with oral dose of mercuric chloride (4 mg/kg) for 30 and 60 days, and 4-origanum oil + mercuric chloride group treated with both origanum oil and mercuric chloride (5 and 4 mg/kg, respectively) for 30 and 60 days. All treatments were carried out by stomach tube...
June 14, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28616611/technical-success-and-short-term-results-of-surgical-treatment-of-gastrointestinal-stromal-tumors-an-experience-of-three-centers
#8
Mark Igorevich Gluzman, Victor Anatolevich Kashchenko, Aleksei Mikhailovich Karachun, Rashida Vakhidovna Orlova, Iakov Aleksandrovich Nakatis, Iurii Vasilevich Pelipas, Evgenia Leonidovna Vasiukova, Ivan Vladimirovich Rykov, Veronika Vladimirovna Petrova, Svetlana Leonidovna Nepomniashchaia, Anton Sergeevich Klimov
BACKGROUND: Gastrointestinal stromal tumors (GIST) comprise about 80% of gastrointestinal sarcomas. In patients with localized disease, surgery is considered as "Gold Standard" treatment. Organ-sparing radical en-block resection is widely accepted practice. Since lymph node dissection is not routinely indicated, minimally invasive approach is of particular interest. The aim of this study is to investigate the short-term outcomes of different surgical treatment of GISTs. METHODS: We analyzed data of 116 patients who received surgical treatment for localized forms of GIST...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28616604/percutaneous-endoscopic-intragastric-surgery-an-organ-preserving-approach-to-submucosal-tumors-at-esophagogastric-junction
#9
REVIEW
Eiji Kanehira, Aya Kamei Kanehira, Takashi Tanida, Kodai Takahashi, Kazunori Sasaki
As an organ preserving option in the treatment of submucosal tumor found at the esophagogastric junction (EGJ), percutaneous endoscopic intragastric surgery (PEIGS) plays an important role, while it is not commonly performed and there have been very few reports on this unique operation. The current authors have been performing PEIGS since 1993 and have reported on its short- and long-term outcomes from one of the world largest series. Herein its confusing terminology is discussed and techniques of three different types of PEIGS (original PEIGS, single incision PEIGS, and needlescopic PEIGS) are precisely described...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28616402/laparoscopic-and-endoscopic-cooperative-surgery-for-gastrointestinal-tumor
#10
REVIEW
Keiko Niimi, Rei Ishibashi, Takashi Mitsui, Susumu Aikou, Shinya Kodashima, Hiroharu Yamashita, Nobutake Yamamichi, Yoshihiro Hirata, Mitsuhiro Fujishiro, Yasuyuki Seto, Kazuhiko Koike
With technological progress of endoscopic submucosal dissection (ESD) in the last decade, several laparoscopic and endoscopic cooperative surgeries (LECS) for gastrointestinal tumor have recently been developed. LECS is definitely favorable to the minimization of surgical margin, which leads to functional and anatomical preservation of gastrointestinal tract. LECS for gastrointestinal tumor is mainly sorted by two categories: exposure procedures and non-exposure procedures between endoluminal and extraluminal spaces...
April 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28612534/-associations-of-preoperative-platelet-to-lymphocyte-ratio-and-derived-neutrophil-to-lymphocyte-ratio-with-theprognosis-of-gastrointestinal-stromal-tumor
#11
Xiao-Nan Yin, Su-Min Tang, Yuan Yin, Chao-Yong Shen, Bo Zhang, Zhi-Xin Chen
OBJECTIVES: To determine the associations of preoperative platelet-to-lymphocyte ratio (PLR) and derived neutrophil-to-lymphocyte ratio (d-NLR) with the prognosis of gastrointestinal stromal tumor (GIST). METHODS: GIST patients with surgical treatment from June 2005 to February 2015 in West China Hospital of Sichuan University were enrolled in the study. The results of blood routine tests of the patients within one week prior to surgery and their clinical data were extracted...
March 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28612014/oligometastatic-disease-in-upper-gastrointestinal-cancer-how-to-proceed
#12
REVIEW
Costanza Chiapponi, Felix Berlth, Patrick S Plum, Christopher Betzler, Dirk L Stippel, Felix Popp, Christiane J Bruns
BACKGROUND: In the present study we review and discuss the current evidence and suggest how to proceed in the management of oligometastatic disease in upper gastrointestinal cancer. METHODS: An electronic search of the PubMed database for relevant articles was performed. RESULTS: Both the search for 'oligometastasis', 'oligometastases', 'oligometastatic', 'oligometastatic disease' as well as 'esophageal' and 'esophageal cancer' and the search for 'oligometastasis', 'oligometastases', 'oligometastatic', 'oligometastatic disease' as well as 'gastric', 'gastric cancer', 'stomach', and 'stomach cancer' yielded very few studies...
March 2017: Visceral Medicine
https://www.readbyqxmd.com/read/28609761/clinical-usefulness-of-somatostatin-receptor-scintigraphy-in-japanese-patients-with-gastroenteropancreatic-neuroendocrine-tumors
#13
Sho Hasegawa, Noritoshi Kobayashi, Motohiko Tokuhisa, Ayumu Goto, Shoko Takano, Yuuki Takada, Tomohiro Kaneta, Ryutaro Mori, Ryusei Matsuyama, Itaru Endo, Shoji Yamanaka, Atsushi Nakajima, Tomio Inoue, Yasushi Ichikawa
BACKGROUND/AIMS: Somatostatin receptor (SSTR) scintigraphy (SRS) is the standard imaging modality for evaluation of gastroenteropancreatic neuroendocrine tumor (GEP-NET) in Western countries. However, this modality was not approved in Japan until recently. The purpose of this study was to evaluate the clinical efficacy of SRS for detecting GEP-NET in Japanese patients. METHODS: Japanese patients with advanced GEP-NET were enrolled and evaluated by the SRS and CT...
June 14, 2017: Digestion
https://www.readbyqxmd.com/read/28608155/pathophysiology-of-gastric-nets-role-of-gastrin-and-menin
#14
REVIEW
Sinju Sundaresan, Anthony J Kang, Juanita L Merchant
PURPOSE OF REVIEW: Neuroendocrine tumors (NETs) were initially identified as a separate entity in the early 1900s as a unique malignancy that secretes bioactive amines. GI-NETs are the most frequent type and represent a unique subset of NETs, because at least 75% of these tumors represent gastrin stimulation of the enterochromaffin-like cell located in the body of the stomach. The purpose of this review is to understand the specific role of gastrin in the generation of Gastric NETs (G-NETs)...
July 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28607325/implication-of-phf2-expression-in-clear-cell-renal-cell-carcinoma
#15
Cheol Lee, Bohyun Kim, Boram Song, Kyung Chul Moon
Background: Clear cell renal cell carcinoma (CCRCC) is presumed to be associated with adipogenic differentiation. Histone modification is known to be important for adipogenesis, and the function of histone demethylase plant homeodomain finger 2 (PHF2) has been noted. In addition, PHF2 may act as a tumor suppressor via epigenetic regulation of p53 and is reported to be reduced in colon cancer and stomach cancer tissues. In this study, we examined PHF2 expression in CCRCC specimens by immunohistochemistry...
June 13, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28604382/surgical-treatment-of-gastric-stromal-tumors-laparoscopic-versus-open-approach
#16
Monica Ortenzi, Roberto Ghiselli, Luca Cardinali, Mario Guerrieri
AIM: Gastrointestinal stromal tumors (GIST) are quite rare tumors, but yet they are the most common mesenchymal lesions of gastrointestinal tract. Their outmost frequent origin site is stomach and presently surgical resection is the mainstay in the treatment of gastric non metastatic GIST. Their peculiar characteristic of growth and poor metastatic tendency make this tumors particularly prone to be managed by minimally invasive technique. Presenting our experience we want show the feasibility and safeness of laparoscopic approach for gastric GIST and its benefits versus traditional open surgery and pointing out short term and long terms outcomes...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28603843/characterization-of-vsig1-exerting-a-tumor-suppressor-function-in-gastric-lung-and-esophageal-cancer-cells
#17
Yusuke Inoue, Shun Matsuura, Katsuhiro Yoshimura, Yuji Iwashita, Tomoaki Kahyo, Akikazu Kawase, Masayuki Tanahashi, Matsuyoshi Maeda, Hiroshi Ogawa, Naoki Inui, Kazuhito Funai, Kazuya Shinmura, Hiroshi Niwa, Takafumi Suda, Haruhiko Sugimura
V-set and immunoglobulin domain containing 1 (VSIG1) is a newly discovered member of the immunoglobulin superfamily proteins, expressed in normal stomach and testis. In cancers, however, the clinical and biological roles of VSIG1 remain unknown. Here we investigated VSIG1 expression in 11 cancers and assessed the prognostic roles of VSIG1 in patients with gastric cancer (GC) (N = 362) and non-small-cell lung cancer (N = 650). VSIG1 was downregulated in 60.5% of GC specimens, and high VSIG1 expression was identified as an independent favorable prognostic factor for overall survival in GC patients (hazard ratio, 0...
June 12, 2017: Cancer Science
https://www.readbyqxmd.com/read/28599230/a-case-of-pancreatic-schwannoma-showing-increased-fdg-uptake-on-pet-ct
#18
Sotaro Fukuhara, Saburo Fukuda, Hirofumi Tazawa, Kouki Imaoka, Tetsuya Mochizuki, Yuzo Hirata, Seiji Fujisaki, Mamoru Takahashi, Toshihiro Nishida, Hideto Sakimoto
INTRODUCTION: Schwannomas are neoplasms originating from Schwann cells in nerve sheath, but pancreatic schwannomas are rare. PRESENTATION OF CASE: A 59-year-old female incidentally pointed out a 2-cm-sized solid mass in the pancreas head by computed tomography (CT) which was performed for other reasons. Magnetic resonance imaging (MRI) showed a mass with hypointensity on T1-weighted images and a heterogenous hyperintensity on T2-weighted images. Magnetic resonance cholangiopancreatography (MRCP) showed no abnormal findings in the main pancreatic duct...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28598818/the-impact-of-pathologic-differentiation-well-poorly-and-the-degree-of-ki-67-index-in-patients-with-metastatic-who-grade-3-gep-necs
#19
Hee Kyung Kim, Sang Yun Ha, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Young Suk Park, Seung Tae Kim
We investigated the impact of pathologic differentiation (well or poorly differentiated) in metastatic grade 3 GEP-NEC patients receiving etoposide and platinum (EP)-based therapy, and evaluated a more exact Ki67 index cut-off point to select patients with grade 3 GEP-NEC who might benefit from EP-based therapy. A total of 31 patients with metastatic grade 3 GEP-NECs receiving EP-based therapy were included in this study. Primary sites included 13 foregut-derived GEP-NECs [stomach (n = 4), duodenum (n = 4), and pancreas (n = 5)] and 2 hindgut-derived GEP-NECs of the rectum...
May 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28595816/impact-of-body-mass-index-on-the-short-term-outcomes-of-resected-gastrointestinal-stromal-tumors
#20
Zachary E Stiles, Tyler M Rist, Paxton V Dickson, Evan S Glazer, Martin D Fleming, David Shibata, Jeremiah L Deneve
BACKGROUND: Potentially curative treatment for gastrointestinal stromal tumors (GIST) involves resection with selective utilization of tyrosine kinase inhibitors. A potential association between obesity and GIST has been postulated as GIST is among the most common incidental findings during gastric resection for bariatric procedures. The purpose of this study is to investigate the relationship and impact of obesity on the pathologic and short-term outcomes in patients with GIST. METHODS: We performed a retrospective review of patients with resected GIST...
May 10, 2017: Journal of Surgical Research
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