keyword
Keywords (Muscle protein breakdown) OR ...

(Muscle protein breakdown) OR (Muscle protein degradation) OR (Muscle Atrophy)

https://read.qxmd.com/read/38518644/identification-of-peucedanum-japonicum-thunb-extract-components-and-their-protective-effects-against-dexamethasone-induced-muscle-atrophy
#21
JOURNAL ARTICLE
Young In Kim, Hyunjung Lee, Min Jung Kim, Chang Hwa Jung, Young-Soo Kim, Jiyun Ahn
BACKGROUND: Peucedanum japonicum Thunb. (PJ) is a vegetable widely consumed in East Asia and is known to have anticancer and anti-inflammatory effects. However, the effect of PJ on muscle atrophy remains elusive. PURPOSE: This study aimed to investigate the effect of PJ and its active compound on dexamethasone (DEX)-induced muscle atrophy. METHODS: We performed qualitative and quantitative analysis of PJ using ultra-performance liquid chromatography-mass spectrometry tandem mass spectrometry (UPLC-MS/MS) and high-performance liquid chromatography (HPLC), respectively...
February 13, 2024: Phytomedicine
https://read.qxmd.com/read/38517625/the-changes-in-abdominal-wall-muscles-following-incisional-hernia-wall-reconstruction
#22
JOURNAL ARTICLE
Z Wang, X Wang, C Wang, Y Zhao
PURPOSE: The objective of incisional hernia surgery is to achieve the restoration of abdominal wall anatomical and physiological functions. This study aims to investigate the impact of abdominal wall reconstruction on abdominal muscle alterations by measuring the preoperative and postoperative changes in abdominal wall muscles in patients undergoing incisional hernia repair. METHODS: For patients undergoing open incisional hernia abdominal wall reconstruction, preoperative and postoperative abdominal CT scans were analyzed at a minimum of 3 months post-surgery...
March 22, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/38517523/phenotype-variability-and-natural-history-of-x-linked-myopathy-with-excessive-autophagy
#23
JOURNAL ARTICLE
Gorka Fernández-Eulate, Girolamo Alfieri, Marco Spinazzi, Isabelle Ackermann-Bonan, Fanny Duval, Guilhem Solé, Florence Caillon, Sandra Mercier, Yann Pereon, Armelle Magot, Antoine Pegat, Emmanuelle Salort-Campana, Brigitte Chabrol, Svetlana Gorokhova, Martin Krahn, Valerie Biancalana, Teresinha Evangelista, Anthony Behin, Corinne Metay, Tanya Stojkovic
OBJECTIVE: X-linked myopathy with excessive autophagy (XMEA) linked to the VMA21 gene leads to autophagy failure with progressive vacuolation and atrophy of skeletal muscles. Current knowledge of this rare disease is limited. Our objective was to define the clinical, radiological, and natural history of XMEA. METHODS: We conducted a retrospective study collecting clinical, genetic, muscle imaging, and biopsy data of XMEA patients followed in France and reviewed the literature for additional cases...
March 22, 2024: Journal of Neurology
https://read.qxmd.com/read/38517246/chronic-critical-illness-induced-muscle-atrophy-insights-from-a-trauma-mouse-model-and-potential-mechanism-mediated-via-serum-amyloid-a
#24
JOURNAL ARTICLE
Mingxing Lei, Taojin Feng, Mingming Zhang, Feifan Chang, Jiang Liu, Baisheng Sun, Ming Chen, Yi Li, Licheng Zhang, Peifu Tang, Pengbin Yin
BACKGROUND: Chronic critical illness (CCI), which was characterized by persistent inflammation, immunosuppression, and catabolism syndrome (PICS), often leads to muscle atrophy. Serum amyloid A (SAA), a protein upregulated in critical illness myopathy, may play a crucial role in these processes. However, the effects of SAA on muscle atrophy in PICS require further investigation. This study aims to develop a mouse model of PICS combined with bone trauma to investigate the mechanisms underlying muscle weakness, with a focus on SAA...
February 27, 2024: Shock
https://read.qxmd.com/read/38515451/neurophysiological-indices-for-split-phenomena-correlation-with-age-and-sex-and-potential-implications-in-amyotrophic-lateral-sclerosis
#25
JOURNAL ARTICLE
Stefano Zoccolella, Giammarco Milella, Alessia Giugno, Vito Devitofrancesco, Rosaria Damato, Ludovica Tamburrino, Salvatore Misceo, Marco Filardi, Giancarlo Logroscino
BACKGROUND: Split phenomena (SP) are characterized by patterns of differential muscle wasting and atrophy, which are highly prevalent in amyotrophic lateral sclerosis (ALS) patients. Several neurophysiological indicators, including the split-hand index (SHI), split-leg index (SLI), and split-elbow index (SEI), have been proposed to assess SP. Nevertheless, their cutoff values and the impact of age and sex on these measures remain unclear. METHODS: We prospectively collected neurophysiological data from 300 healthy adult subjects...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38512601/mitigating-factors-in-l4-and-l5-medial-branch-motor-stimulation-during-radiofrequency-ablation
#26
REVIEW
Mihir Jani, Nimesha Mehta, Sandra Yu, Ricky Ju, Ugur Yener, Alaa Abd-Elsayed, Lynn Kohan, Sayed Emal Wahezi
PURPOSE OF REVIEW: Radiofrequency ablation (RFA) is a minimally invasive procedure for facet joint pain. The targets for the procedure are the medial branches of the dorsal spinal nerves which innervate the facet joints. Before RFA, patients undergo diagnostic meal branch blocks to ensure appropriate pain relief and confirm the utility of proceeding to RFA. The success of RFA relies heavily on procedural technique and accurate placement near the medial branch. RECENT FINDINGS: Motor testing is utilized in the lumbar region to assess the response of the multifidus and ensure proper placement of the RFA probe to prevent inadvertent damage to surrounding spinal anatomy...
March 21, 2024: Current Pain and Headache Reports
https://read.qxmd.com/read/38511212/age-related-blunting-of-serial-sarcomerogenesis-and-mechanical-adaptations-following-4-weeks-of-maximal-eccentric-resistance-training
#27
JOURNAL ARTICLE
Avery Hinks, Makenna A Patterson, Binta S Njai, Geoffrey A Power
During aging, muscles atrophy, which is partly accounted for by a loss of sarcomeres in series. Serial sarcomere number (SSN) is associated with aspects of muscle mechanical function including the force-length and force-velocity-power relationships; hence, the age-related loss of SSN contributes to declining performance. Training emphasizing eccentric contractions increases SSN in young healthy rodents, however, the ability for eccentric training to increase SSN in old age is unknown. Ten young (8 months) and 11 old (32 months) male Fisher344/BN rats completed 4 weeks of unilateral eccentric plantar flexion training...
March 21, 2024: Journal of Applied Physiology
https://read.qxmd.com/read/38510868/multidisciplinary-management-and-rehabilitation-of-severe-crush-injury-resulting-in-lisfranc-fracture-a-case-report
#28
Radha Nangliya, Sojwal P Nandanwar, Maithili Deshpande
A 58-year-old male patient was seriously injured in his left foot as a result of a passenger car accident, resulting in a Lisfranc fracture and complications on his left side. The initial injury resulted in a 20-cm laceration, severe pain, and severe swelling. After primary care at the government hospital, the patient was referred to Acharya Vinoba Bhave Rural Hospital (AVBRH) for further treatment. Clinical examination revealed infection, Lisfranc ligament rupture, bone exposure, restriction of movement, and muscle strength...
February 2024: Curēus
https://read.qxmd.com/read/38503830/troponin-t-is-elevated-in-a-relevant-proportion-of-patients-with-5q-associated-spinal-muscular-atrophy
#29
JOURNAL ARTICLE
Hanna Sophie Lapp, Maren Freigang, Johannes Friese, Sarah Bernsen, Victoria Tüngler, Maja von der Hagen, Patrick Weydt, René Günther
Troponin T concentration (TNT) is commonly considered a marker of myocardial damage. However, elevated concentrations have been demonstrated in numerous neuromuscular disorders, pointing to the skeletal muscle as a possible extracardiac origin. The aim of this study was to determine disease-related changes of TNT in 5q-associated spinal muscular atrophy (SMA) and to screen for its biomarker potential in SMA. We therefore included 48 pediatric and 45 adult SMA patients in this retrospective cross-sequential observational study...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38502585/yap-taz-as-molecular-targets-in-skeletal-muscle-atrophy-and-osteoporosis
#30
REVIEW
Youngjoo Kwon
Skeletal muscles and bones are closely connected anatomically and functionally. Age-related degeneration in these tissues is associated with physical disability in the elderly and significantly impacts their quality of life. Understanding the mechanisms of age-related musculoskeletal tissue degeneration is crucial for identifying molecular targets for therapeutic interventions for skeletal muscle atrophy and osteoporosis. The Hippo pathway is a recently identified signaling pathway that plays critical roles in development, tissue homeostasis, and regeneration...
March 14, 2024: Aging and Disease
https://read.qxmd.com/read/38500424/-comparison-of-talonavicular-cuneiform-joint-fusion-with-bone-grafting-and-without-bone-grafting-in-treatment-of-m%C3%A3-ller-weiss-disease
#31
JOURNAL ARTICLE
Baoli Zou, Wenbo Bai, Guodong Shen, Kaiting Zhang, Jingcheng Xu, Yongzhan Zhu
OBJECTIVE: To compare the effectiveness of talonavicular-cuneiform joint fusion with iliac bone grafting and without bone grafting in the treatment of Müller-Weiss diseases (MWD). METHODS: The clinical data of 44 patients (44 feet) with MWD who received talonavicular-cuneiform joint fusion between January 2017 and November 2022 and met the selection criteria was retrospectively analyzed. Among them, 25 patients were treated with structural iliac bone grafting (bone grafting group) and 19 patients without bone grafting (non-bone grafting group)...
March 15, 2024: Chinese Journal of Reparative and Reconstructive Surgery
https://read.qxmd.com/read/38499261/banxia-xiexin-decoction-promotes-gastric-lymphatic-pumping-by-regulating-lymphatic-smooth-muscle-cell-contraction-and-energy-metabolism-in-a-stress-induced-gastric-ulceration-rat-model
#32
JOURNAL ARTICLE
Shutao Pan, Xue Yu, Mingyu Liu, Jiaqi Liu, Chunguo Wang, Yao Zhang, Fei Ge, Angran Fan, Dongmei Zhang, Meng Chen
ETHNOPHARMACOLOGICAL RELEVANCE: The traditional Chinese medicine (TCM) formula Banxia Xiexin decoction (BXD) has definite therapeutic effect in treating stress-induced gastric ulceration (SIGU) and many other gastrointestinal diseases, but its effect on gastric lymphatic pumping (GLP) remains unclear. AIM OF THE STUDY: Elucidating the role of GLP in SIGU and BXD treatment, and exploring the molecular mechanisms of GLP regulation. MATERIALS AND METHODS: In vivo GLP imaging were performed on SIGU rat model, and the lymphatic dynamic parameters were evaluated...
March 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38497799/unveiling-therapeutic-prospects-targeting-mdm-2-in-non-muscle-invasive-bladder-cancer
#33
JOURNAL ARTICLE
Hongjian Wu, Hui Jin, Yongjian Cai
Non-muscle invasive bladder cancer (NMIBC) is considered one of the most costly malignancies, requiring significant surgical and therapeutic measures. However, progression and non-responsiveness to immunotherapy are common outcomes of treatment. In this study, we conducted comparative transcriptomic analysis of non-responders from two distinct populations (Asian and American) and identified six common genes associated with disease prognosis. Among these genes, MDM-2 is a major oncogenic protein linked to seven different types of cancers, as it is involved in the degradation of the tumor suppressor protein p53...
March 18, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38496429/a-novel-variant-in-the-gne-gene-in-a-malian-patient-presenting-with-distal-myopathy
#34
Mahamadou Kotioumbe, Alassane B Maiga, Salia Bamba, Lassana Cissé, Salimata Diarra, Salimata Diallo, Abdoulaye Yalcouyé, Fousseyni Kané, Seybou H Diallo, Dramane Coulibaly, Thomas Coulibaly, Kékouta Dembélé, Boubacar Maiga, Cheick O Guinto, Guida Landouré
Background: GNE myopathy (GM) is a rare autosomal recessive disorder caused by variants in the GNE gene and characterized by progressive distal muscle weakness and atrophy. We report a novel variant in the GNE gene causing GM in a consanguineous Malian family. Case presentation: A 19-year-old male patient from a consanguineous family of Bambara ethnicity was seen for progressive walking difficulty and frequent falls. Neurological examination found distalmuscle weakness and atrophy and reduced tendon reflexes in four limbs...
March 7, 2024: Research Square
https://read.qxmd.com/read/38496299/quadriceps-muscle-atrophy-after-non-invasive-anterior-cruciate-ligament-injury-evidence-linking-to-autophagy-and-mitophagy
#35
JOURNAL ARTICLE
Sung Gi Noh, Ahram Ahn, Steven M Davi, Lindsey K Lepley, Oh Sung Kwon
Introduction: Anterior cruciate ligament (ACL) injury is frequently accompanied by quadriceps muscle atrophy, a process closely linked to mitochondrial health and mitochondria-specific autophagy. However, the temporal progression of key quadricep atrophy-mediating events following ACL injury remains poorly understood. To advance our understanding, we conducted a longitudinal study to elucidate key parameters in quadriceps autophagy and mitophagy. Methods: Long-Evans rats were euthanized at 7, 14, 28, and 56 days after non-invasive ACL injury that was induced via tibial compression overload; controls were not injured...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38496008/cigarette-smoking-inhibits-myoblast-regeneration-by-promoting-proteasomal-degradation-of-npat-protein-and-hindering-cell-cycle-progression
#36
JOURNAL ARTICLE
Jianfeng Wang, Jinling Liu, Jingjing Shao, Hongyu Chen, Luyun Cui, Pei Zhang, Yinan Yao, Jianying Zhou, Zhang Bao
Cigarette smoking (CS) causes skeletal muscle dysfunction, leading to sarcopenia and worse prognosis of patients with diverse systemic diseases. Here, we found that CS exposure prevented C2C12 myoblasts proliferation in a dose-dependent manner. Immunoblotting assays verified that CS exposure promoted the expression of cell cycle suppressor protein p21. Furthermore, CS exposure significantly inhibited replication-dependent (RD) histone transcription and caused S phase arrest in the cell cycle during C2C12 proliferation...
2024: Current research in toxicology
https://read.qxmd.com/read/38494747/rapid-eye-movement-sleep-behavior-disorder-and-its-relation-to-parkinson-s-disease-the-potential-of-graph-measures-as-brain-biomarkers-to-identify-the-underlying-physiopathology-of-the-disorder
#37
REVIEW
Milad Najafzadeh, Fatemeh Mohammadian, Sara Mirabian, Zohre Ganji, Hossein Akbari, Masoud Rezaie, Esmaeil Ranjbar, Hoda Zare, Shahrokh Nasseri, Luigi Ferini-Strambi
Rapid eye movement behavior disorder (RBD) is a parasomnia characterized by the loss of skeletal muscle atonia during the rapid eye movement (REM) sleep phase. On the other hand, idiopathic RDB (iRBD) is considered the prelude of the various α-synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy. Consequently, over 40% of patients eventually develop PD. Recent neuroimaging studies utilizing structural magnetic resonance imaging (s-MRI), diffusion-weighted imaging (DWI), and functional magnetic resonance imaging (fMRI) with graph theoretical analysis have demonstrated that patients with iRBD and Parkinson's disease have extensive brain abnormalities...
March 2024: Brain and Behavior
https://read.qxmd.com/read/38493058/neuroprotective-effects-of-niclosamide-on-disease-progression-via-inflammatory-pathways-modulation-in-sod1-g93a-and-fus-associated-amyotrophic-lateral-sclerosis-models
#38
JOURNAL ARTICLE
Martina Milani, Ilaria Della Valle, Simona Rossi, Paola Fabbrizio, Cassandra Margotta, Giovanni Nardo, Mauro Cozzolino, Nadia D'Ambrosi, Savina Apolloni
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease influenced by genetic, epigenetic, and environmental factors, resulting in dysfunction in cellular and molecular pathways. The limited efficacy of current treatments highlights the need for combination therapies targeting multiple aspects of the disease. Niclosamide, an anthelminthic drug listed as an essential medicine, has been repurposed in clinical trials for different diseases due to its anti-inflammatory and anti-fibrotic properties...
March 15, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38492879/skeletal-muscle-atrophy-after-sciatic-nerve-damage-mechanistic-insights
#39
REVIEW
Aarti Yadav, Rajesh Dabur
Sciatic nerve injury leads to molecular events that cause muscular dysfunction advancement in atrophic conditions. Nerve damage renders muscles permanently relaxed which elevates intracellular resting Ca2+ levels. Increased Ca2+ levels are associated with several cellular signaling pathways including AMPK, cGMP, PLC-β, CERB, and calcineurin. Also, multiple enzymes involved in the tricarboxylic acid cycle and oxidative phosphorylation are activated by Ca2+ influx into mitochondria during muscle contraction, to meet increased ATP demand...
March 14, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38492659/mechanical-and-signaling-responses-of-unloaded-rat-soleus-muscle-to-chronically-elevated-%C3%AE-myosin-activity
#40
JOURNAL ARTICLE
K V Sergeeva, S A Tyganov, K A Zaripova, R O Bokov, L V Nikitina, T S Konstantinova, G R Kalamkarov, B S Shenkman
It has been reported that muscle functional unloading is accompanied by an increase in motoneuronal excitability despite the elimination of afferent input. Thus, we hypothesized that pharmacological potentiation of spontaneous contractile soleus muscle activity during hindlimb unloading could activate anabolic signaling pathways and prevent the loss of muscle mass and strength. To investigate these aspects and underlying molecular mechanisms, we used β-myosin allosteric effector Omecamtiv Mekarbil (OM)...
March 14, 2024: Archives of Biochemistry and Biophysics
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