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Yukako Nakanishi, Kazuhiro Kitajima, Yusuke Yamada, Takahiko Hashimoto, Toru Suzuki, Shuken Go, Akihiro Kanematsu, Michio Nojima, Koichiro Yamakado, Shingo Yamamoto
PURPOSE: To compare findings obtained with 11 C-choline and FDG PET/CT scanning for renal cell carcinoma staging and restaging. MATERIALS AND METHODS: Twenty-eight renal cell carcinoma patients whose histological subtype was clear cell type in 26 and papillary type in 2, while Fuhrman nuclear grade was G1,2 in 16 and G3,4 in 12, underwent both 11 C-choline and FDG PET/CT examinations before (n = 10) and/or after (n = 18) treatment, then those scanning modalities were compared in regard to patient- and lesion-based diagnostic performance using 5 grading scores...
August 17, 2018: Annals of Nuclear Medicine
Ken Hashimoto, Aya Kodama, Miki Sugino, Tomoko Yobimoto, Takeshi Honda, Akira Hanashima, Yoshihiro Ujihara, Satoshi Mohri
Loss of cardiomyocyte proliferative capacity after birth is a major obstacle for therapeutic heart regeneration in adult mammals. We and others have recently shown the importance of hypoxic in utero environments for active foetal cardiomyocyte proliferation. Here, we report the unexpected expression of novex-3, the short splice variant of the giant sarcomeric protein connectin (titin), in the cardiomyocyte nucleus specifically during the hypoxic foetal stage in mice. This nuclear localisation appeared to be regulated by the N-terminal region of novex-3, which contains the nuclear localisation signal...
August 17, 2018: Scientific Reports
Masataka Kikuchi, Kenichiro Miura, Kentaro Morita, Hidenaga Yamamori, Michiko Fujimoto, Masashi Ikeda, Yuka Yasuda, Akihiro Nakaya, Ryota Hashimoto
Eye movements are considered endophenotypes of schizophrenia. However, the genetic factors underlying eye movement are largely unknown. In this study, we explored the susceptibility loci for four eye movement scores: the scanpath length during the free viewing test (SPL), the horizontal position gain during the fast Lissajous paradigm of the smooth pursuit test (HPG), the duration of fixations during the far distractor paradigm of the fixation stability test (DF) and the integrated eye movement score of those three scores (EMS)...
August 17, 2018: Scientific Reports
Mari Shimizu, Hajime Matsumine, Hironobu Osaki, Yoshihumi Ueta, Satoshi Tsunoda, Wataru Kamei, Kazuki Hashimoto, Yosuke Niimi, Yorikatsu Watanabe, Mariko Miyata, Hiroyuki Sakurai
Adipose-derived stem cells (ADSCs) and the stromal vascular fraction (SVF) promote nerve regeneration. Biodegradable nerve conduits are used to treat peripheral nerve injuries, but their efficiencies are lower than those of autologous nerve grafts. This study developed biodegradable nerve conduits containing ADSCs and SVF and evaluated their facial nerve regenerating abilities in a rat model with a 7-mm nerve defect. SVF and ADSCs were individually poured into nerve conduits with PGA-type I collagen as a scaffold (ADSCs and SVF groups)...
August 17, 2018: Wound Repair and Regeneration
Takanori Asakura, Makoto Ishii, Ho Namkoong, Shoji Suzuki, Shizuko Kagawa, Kazuma Yagi, Takaki Komiya, Takafumi Hashimoto, Satoshi Okamori, Hirofumi Kamata, Sadatomo Tasaka, Akio Kihara, Ahmed E Hegab, Naoki Hasegawa, Tomoko Betsuyaku
Sphingolipids play a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, little is known about the precise roles of sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, and its receptor modulation in COPD. In this study, we demonstrated that the S1P receptor modulator ONO-4641 induced the expansion of lung CD11b+ Gr-1+ cells and lymphocytopenia in naive mice. ONO-4641-expanded CD11b+ Gr-1+ cells showed higher arginase-1 activity, decreased T cell proliferation, and lower IFN-γ production in CD3+ T cells, similar to the features of myeloid-derived suppressor cells...
August 16, 2018: Mucosal Immunology
Larissa C Faustino, Angela Lombardi, Julio Madrigal-Matute, Randall P Owen, Steven K Libutti, Yaron Tomer
Context: Autoimmune thyroid diseases (AITD) arise from complex interactions between genetic, epigenetic and environmental factors. Thyroglobulin (TG) is a major susceptibility gene for both Graves' disease and Hashimoto's thyroiditis. Interferon-alpha (IFNα), a cytokine secreted during viral infections, has recently emerged as a key trigger of AITD. We have previously shown that IFNα upregulates TG transcription, however, how the upregulation of TG transcription by IFNα triggers AITD is still unknown...
August 2, 2018: Journal of Clinical Endocrinology and Metabolism
Kazuhiko Hashimoto, Shunji Nishimura, Naohiro Oka, Hiroki Tanaka, Ryosuke Kakinoki, Masao Akagi
Superficial acral fibromyxoma is a very rare soft tissue tumor. Fetsch et al first described the condition in 2001. It often occurs in the fingers and toes and has slow-progressive features. Since being described, a few cases occurring in the great toe have been reported. The present study indicated a case of a 37-year-old male kickboxer with a history of a rapid-growing lump under the nail of his left great toe with bone erosion. The patient was suspected to have a soft tissue tumor under the nail, such as a glomus tumor, as a differential diagnosis...
September 2018: Molecular and Clinical Oncology
Masato Nishimura, Toshiko Tokoro, Toru Takatani, Nodoka Sato, Tetsuya Hashimoto, Hiroyuki Kobayashi, Toshihiko Ono
AIM: Type Ⅲ collagen abundantly exists in the cardiovascular system, including the aorta and heart. We prospectively investigated whether serum levels of aminoterminal propeptide of type Ⅲ procollagen (PⅢNP), a circulating biomarker of cardiovascular fibrosis, could predict cardiovascular events in patients undergoing hemodialysis. METHODS: Serum PⅢNP concentrations were measured in 244 patients undergoing maintenance hemodialysis (men, 126; women, 118; mean age, 64±11 years; dialysis duration, 11...
August 15, 2018: Journal of Atherosclerosis and Thrombosis
Jun Hashimoto, Ken Kato, Yoshinori Ito, Takashi Kojima, Tetsuo Akimoto, Hiroyuki Daiko, Yasuo Hamamoto, Hisayuki Matsushita, Susumu Katano, Hiroki Hara, Yoichi Tanaka, Yoshihiro Saito, Kengo Nagashima, Hiroyasu Igaki
BACKGROUND: Preoperative chemoradiotherapy (CRT) is a standard treatment for stage II/III esophageal cancer. Preoperative chemotherapy is also considered a standard treatment for stage II/III esophageal squamous cell carcinoma (ESCC) in patients who undergo radical lymph node dissection. We conducted a feasibility study of preoperative CRT with cisplatin plus 5-fluorouracil (CF) and elective lymph node irradiation followed by esophagectomy with radical lymph node dissection in patients with stage II/III ESCC...
August 14, 2018: International Journal of Clinical Oncology
Ryota Tamate, Kei Hashimoto, Takeshi Ueki, Masayoshi Watanabe
Ionic liquids (ILs), solely composed of cations and anions, are regarded as a novel class of promising liquids, potentially applicable to energy devices, reaction media, separation materials, etc. ILs have also attracted great attention as new media for molecular self-assembly, capable of producing novel soft materials with unique features never observed for conventional soft materials containing organic and aqueous solvents. In this review, we focus on recent developments in block copolymer (BCP) self-assembly in ILs...
August 15, 2018: Physical Chemistry Chemical Physics: PCCP
Tomohiro Omura, Miwa Sasaoka, Gaia Hashimoto, Satoshi Imai, Joe Yamamoto, Yuki Sato, Shunsaku Nakagawa, Atsushi Yonezawa, Takayuki Nakagawa, Ikuko Yano, Yoshikazu Tasaki, Kazuo Matsubara
We have previously reported that oxicam-derived non-steroidal anti-inflammatory drugs (oxicam-NSAIDs), including meloxicam, piroxicam and tenoxicam, elicit protective effects against 1-methyl-4-phenyl pyridinium (MPP+ )-induced cell death in a fashion independent of cyclooxygenase (COX) inhibition. We have also demonstrated that oxicam-NSAIDs suppress the decrease in phosphorylation of Akt caused by MPP+ . The molecular mechanism through which oxicam-NSAIDs provide cytoprotection remains unclear. In this study, we speculated a possibility that endoplasmic reticulum (ER) stress and/or mitochondrial dysfunction, which are both causative factors of Parkinson's disease (PD), may be involved in the neuroprotective mechanism of oxicam-NSAIDs...
August 11, 2018: Biochemical and Biophysical Research Communications
Antonio Rodríguez-Valiente, Óscar Álvarez-Montero, Carmen Górriz-Gil, José Ramón García-Berrocal
OBJECTIVE: This is the first report dealing with immune-mediated inner ear disease (IMIED) hearing loss in a group of patients affected with autoimmune thyroid disease (AITD), whose treatment required corticosteroids, despite being treated with levothyroxine. Immunopathology linking the inner ear and the thyroid gland is also presented. PATIENTS: A total of 220 patients were selected with sensorineural hearing loss (SNHL) of causes other than presbycusis. Audiometry was performed and pure tone average was calculated before and after treatment with corticosteroids...
August 11, 2018: Acta Otorrinolaringológica Española
Erika L Sabbath, Dean Hashimoto, Leslie I Boden, Jack T Dennerlein, Jessica A R Williams, Karen Hopcia, Theresa Orechia, Yorghos Tripodis, Anne Stoddard, Glorian Sorensen
No abstract text is available yet for this article.
August 10, 2018: International Journal of Epidemiology
Hana Aldaajani, Salma Albahrani, Khalid Saleh, Khawla Alghanim
A 43-year-old man with Hashimoto's thyroiditis and previous thromboembolic events treated with warfarin for 6 months, presented with right flank pain accompanied with vomiting, dizziness, and altered mental status 2 weeks after discontinuation of warfarin. His clinical examination findings were unremarkable. Routine blood work showed lymphopenia, thrombocytopenia, and hypoosmolar hyponatremia. Random serum cortisol level was low (14 nmol/L). Computed tomography scan of the abdomen revealed bilateral bulky heterogeneous suprarenal gland surrounded by fat stranding representing adrenal hemorrhage...
August 2018: Saudi Medical Journal
Kohsuke Hagisawa, Manabu Kinoshita, Bonpei Takase, Kenichi Hashimoto, Daizoh Saitoh, Shuhji Seki, Yasuhiro Nishida, Hiromi Sakai
INTRODUCTION: We have developed hemoglobin vesicles (HbVs) as a substitute for red blood cells (RBCs). We investigated the efficacy of HbV transfusion in the treatment of massive hemorrhage in rabbits in the setting of thrombocytopenic coagulopathy, focusing on the efficacy of hemostasis by subsequent platelet transfusion. METHODS: Thrombocytopenic coagulopathy was induced in rabbits by repeated blood withdrawal and isovolemic retransfusion of autologous RBC (platelet counts <45,000/μL)...
September 2018: Shock
Masayo Fujita, Yoko Hagino, Yukio Takamatsu, Yuka Shimizu, Yoshiki Takamatsu, Kazutaka Ikeda, Makoto Hashimoto
AIM: We previously generated transgenic (Tg) mice that expressed P123H β-synuclein (βS), a dementia with Lewy body-linked mutant βS. Notably, these mice recapitulated neurodegenerative features of Lewy body disease, reflected by motor dysfunction, greater protein aggregation, and memory impairment. Since recent studies suggested that non-motor symptoms, such as depression, might be manifested in the prodromal stage of Lewy body disease, the main objective of the present study was to investigate the early expression of behavior in P123H βS Tg mice...
June 2018: Neuropsychopharmacology reports
Hiroki Kawashima, Yoshiki Hirooka, Eizaburo Ohno, Takuya Ishikawa, Ryoji Miyahara, Osamu Watanabe, Kazuhiko Hayashi, Masatoshi Ishigami, Senju Hashimoto, Tomoki Ebata, Masato Nagino, Hidemi Goto
Background and study aims : To decrease complications associated with preoperative endoscopic nasobiliary drainage (ENBD) for perihilar cholangiocarcinoma patients, we developed a modified 6-Fr ENBD catheter with multiple side holes (m-ENBD). The aim of this retrospective study was to compare the m-ENBD catheter with a conventional 7-Fr ENBD catheter (c-ENBD). Patients and methods : This study involved 371 patients with suspected perihilar cholangiocarcinoma who underwent ENBD using a c-ENBD catheter or an m-ENBD catheter...
August 2018: Endoscopy International Open
Fran Baum, Jennie Popay, Toni Delany-Crowe, Toby Freeman, Connie Musolino, Carlos Alvarez-Dardet, Vinya Ariyaratne, Kedar Baral, Paulin Basinga, Mary Bassett, David M Bishai, Mickey Chopra, Sharon Friel, Elsa Giugliani, Hideki Hashimoto, James Macinko, Martin McKee, Huong Thanh Nguyen, Nikki Schaay, Orielle Solar, Sundararaman Thiagarajan, David Sanders
BACKGROUND: Life expectancy initially improves rapidly with economic development but then tails off. Yet, at any level of economic development, some countries do better, and some worse, than expected - they either punch above or below their weight. Why this is the case has been previously researched but no full explanation of the complexity of this phenomenon is available. NEW RESEARCH NETWORK: In order to advance understanding, the newly formed Punching Above Their Weight Research Network has developed a model to frame future research...
August 13, 2018: International Journal for Equity in Health
Dai Simazaki, Masaaki Hirose, Hisashi Hashimoto, Shunji Yamanaka, Mitsuki Takamura, Junya Watanabe, Michihiro Akiba
Occurrence of residual endotoxin activity (ET) in dialysis water and also tap water as its source is a matter of great concern to medical professionals conducting dialysis therapy at healthcare facilities (HCFs). The present study was performed to determine the occurrence and fate of the ET at selected Japanese drinking water purification plants and HCFs between 2014 and 2016. Chemical coagulation and sedimentation, rapid sand filtration, and membrane filtration were highly effective to decrease both ET dissolved in water (free-ET) and ET bound to cells/particles (bound-ET)...
August 6, 2018: Water Research
Ayumi Matsumoto, Isao Matsui, Takayasu Mori, Yusuke Sakaguchi, Masayuki Mizui, Yoshiyasu Ueda, Atsushi Takahashi, Yohei Doi, Karin Shimada, Satoshi Yamaguchi, Keiichi Kubota, Nobuhiro Hashimoto, Tatsufumi Oka, Yoshitsugu Takabatake, Eisei Sohara, Takayuki Hamano, Shinichi Uchida, Yoshitaka Isaka
We present a case of Dent disease caused by a novel intronic mutation, 1348-1G>A, of the chloride voltage-gated channel 5 (CLCN5) gene. Cultured proximal tubule cells obtained from the patient showed impaired acidification of the endosome and/or lysosome, indicating that the 1348-1G>A mutation was indeed the cause of Dent disease. Although the prevalence of osteomalacia in Dent disease is low in Japan, several factors-including poor medication adherence-caused severe osteomalacia in the current case. Oral supplementation with calcium and native/active vitamin D therapy, with careful attention to medication adherence, led to the improvement of the patient's bone status...
August 10, 2018: Internal Medicine
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