Priyanka Kulkarni, Pritha Dasgupta, Nadeem S Bhat, Yutaka Hashimoto, Sharanjot Saini, Varahram Shahryari, Soichiro Yamamura, Marisa Shiina, Yuichiro Tanaka, Rajvir Dahiya, Shahana Majid
This study investigated the role of the PI3K/Akt pathway in cadmium (Cd) induced malignant transformation of normal prostate epithelial (PWR1E and RWPE1) cells. Both PWR1E and RWPE1 cells were exposed to 10 μM Cd for one year and designated as Cd-PWR1E and Cd-RWPE1. Cd-RWPE1 cells robustly formed tumors in athymic nude mice. Functionally, Cd-exposure induced tumorigenic attributes indicated by increased wound healing, migration and invasion capabilities in both cell lines. RT2 -array analysis revealed many oncogenes including P110α, Akt, mTOR, NFKB1 and RAF were induced whereas tumor suppressor (TS) genes were attenuated in Cd-RWPE1...
December 15, 2020: Toxicology and Applied Pharmacology