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Xiaofei Lv, Xialian Tang, Jinbin Lai, Wenhui Ye, Guang Shao, Changqing Lin, Xicai Wu, Xili Yang
In this work, we carried out a case-control study to examine the role of CTLA4 49 A→G (rs231775), IL1B -511 C→T (rs16944), IL10 -1082 A→G (rs1800896), IL10 -592 A→C (rs1800872), IL12B 3'UTR 1188 A→C (rs 3212227) and IL18 105 A→C (rs549908) polymorphisms on the risk of Hashimoto's thyroiditis among Han Chinese. The six polymorphisms were genotyped on 1,114 patients with Hashimoto's thyroiditis and 1,308 age- and sex-matched controls. Odds ratios (ORs) were then calculated via logistic regression model to determine the association present...
October 13, 2018: Human Immunology
Kazuya Murata, Weizhe Lu, Misuzu Hashimoto, Natsumi Ono, Masafumi Muratani, Kana Nishikata, Jun-Dal Kim, Shizufumi Ebihara, Junji Ishida, Akiyoshi Fukamizu
Protein arginine methyltransferase 1 (PRMT1) catalyzes the asymmetric dimethylation of arginine residues in proteins and methylation of various RNA-binding proteins and is associated with alternative splicing in vitro. Although PRMT1 has essential in vivo roles in embryonic development, CNS development, and skeletal muscle regeneration, the functional importance of PRMT1 in the heart remains to be elucidated. Here, we report that juvenile cardiomyocyte-specific PRMT1-deficient mice develop severe dilated cardiomyopathy and exhibit aberrant cardiac alternative splicing...
October 2, 2018: iScience
Jian-Pu Han, Philipp Köster, Maria M Drerup, Martin Scholz, Shizhen Li, Kai H Edel, Kenji Hashimoto, Kazuyuki Kuchitsu, Michael Hippler, Jörg Kudla
RBOHF from Arabidopsis thaliana represents a multifunctional NADPH oxidase regulating biotic and abiotic stress tolerance, developmental processes and guard cell aperture. The molecular components and mechanisms determining RBOHF activity remain to be elucidated. Here we combined protein interaction studies, biochemical and genetic approaches with pathway reconstitution analyses to identify and characterize proteins that confer RBOHF regulation and elucidated mechanisms that adjust RBOHF activity. While the Ca2+ sensor activated kinases CIPK11 and CIPK26 constitute alternative paths for RBOHF activation, the combined activity of CIPKs and the kinase open stomata 1 (OST1) triggers complementary activation of this NADPH oxidase which is efficiently counteracted through dephosphorylation by the phosphatase ABI1...
October 15, 2018: New Phytologist
Shusuke Numata, Hidehiro Umehara, Tetsuro Ohmori, Ryota Hashimoto
Clozapine is an efficacious atypical antipsychotic for treatment-refractory schizophrenia. Clinical response and appearance of adverse events vary among individual patients receiving clozapine, with genetic and non-genetic factors potentially contributing to individual variabilities. Pharmacogenetic studies investigate associations between genetic variants and drug efficacy and toxicity. To date, most pharmacogenetic studies of clozapine have been conducted through candidate gene approaches. A recent advance in technology made it possible to perform comprehensive genetic mapping underlying clinical phenotypes and outcomes, which allow novel findings beyond biological hypotheses based on current knowledge...
2018: Frontiers in Pharmacology
T Hashimoto, D Tsuruta
No abstract text is available yet for this article.
October 2018: British Journal of Dermatology
Hiroshi Saito, Yuya Matsue, Makoto Suzuki, Kentaro Kamiya, Yuki Hasegawa, Yoshiko Endo, Yuri Negishi, Miki Hirano, Kumi Takanashi, Hiromi Iizuka, Akihiko Matsumura, Yuji Hashimoto
OBJECTIVES: Although cognitive impairment is common among patients with chronic heart failure (HF), the accuracy with which caregivers can recognize it is unknown. This study aimed to examine the degree to which subjective and objective evaluations coincide. METHODS: Cognitive function was evaluated subjectively and objectively in 184 hospitalized patients aged 65 or older (82 ± 7.2 years old and 49% male) with HF, who were divided into three groups: (i) normal; (ii) mild cognitive impairment; and (iii) severe cognitive impairment...
October 14, 2018: Australasian Journal on Ageing
Takeshi Noshi, Mitsutaka Kitano, Keiichi Taniguchi, Atsuko Yamamoto, Shinya Omoto, Keiko Baba, Takashi Hashimoto, Kayo Ishida, Yukihiro Kushima, Kazunari Hattori, Makoto Kawai, Ryu Yoshida, Masanori Kobayashi, Tomokazu Yoshinaga, Akihiko Sato, Masatoshi Okamatsu, Yoshihiro Sakoda, Hiroshi Kida, Takao Shishido, Akira Naito
Cap-dependent endonuclease (CEN) resides in the PA subunit of the influenza virus and mediates the critical "cap-snatching" step of viral RNA transcription, which is considered to be a promising anti-influenza target. Here, we describe in vitro characterization of a novel CEN inhibitor, baloxavir acid (BXA), the active form of baloxavir marboxil (BXM). BXA inhibits viral RNA transcription via selective inhibition of CEN activity in enzymatic assays, and inhibits viral replication in infected cells without cytotoxicity in cytopathic effect assays...
October 11, 2018: Antiviral Research
Kayoko Hayakawa, Maki Nagashima, Eriko Kanehisa, Riri Watanabe, Junwa Kunimatsu, Kaichi Ohta, Yoshikazu Mutoh, Takehiro Hashimoto, Yuichi Katanami, Kei Yamamoto, Satoshi Kutsuna, Niro Tayama, Norio Ohmagari
PURPOSE: Recent data suggest an association between Fusobacterium necrophorum infection and pharyngotonsillitis among adolescents and adults. However, existing reports are only from North America and Europe. We aimed to identify and compare the prevalence of F. necrophorum among patients with pharyngitis and asymptomatic controls in Japan and clarify the epidemiological characteristics of pharyngitis. METHODS: Patients aged ≥16 years with pharyngitis and asymptomatic controls were prospectively included...
October 10, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
I Hamano, S Hatakeyama, H Yamamoto, T Fujita, R Murakami, M Shimada, A Imai, T Yoneyama, T Yoneyama, Y Hashimoto, T Koie, S Narumi, H Saitoh, T Suzuki, H Tomita, C Ohyama
BACKGROUND: Condyloma acuminatum (CA) is a common sexually transmitted disease associated with human papilloma virus (HPV). CA occurring in the urethra is rare and has not been reported in male renal transplant recipients. In addition, despite immunosuppressive conditions and increased risk of HPV-related malignant neoplasms in transplant recipients, HPV testing in male transplant recipients has been uncommon. Here we report a case of urethral CA in a male deceased donor renal transplantation recipient and discuss the importance of HPV testing in male transplant recipients...
October 2018: Transplantation Proceedings
K Iwamoto, J Iizuka, Y Hashimoto, T Kondo, T Takagi, K Hata, K Unagami, M Okumi, H Ishida, K Tanabe
OBJECTIVES: We aimed to evaluate the feasibility and efficacy of surgical prostatectomy in renal transplant recipients (RTRs). METHODS: Between January 2008 and February 2017, we identified 13 RTRs who were diagnosed with localized prostate cancer and underwent radical prostatectomy. We reviewed all available clinicopathologic data for these 13 patients. RESULTS: The median patient age was 61 years and median serum prostate-specific antigen (PSA) was 8...
October 2018: Transplantation Proceedings
H Kishikawa, T Kinoshita, M Hashimoto, S Fukae, A Taniguchi, K Yamanaka, M Nakagawa, K Nishimura
OBJECTIVES: We investigated the correlation between class II HLA epitope mismatch and antibody-mediated rejection (AMR) episodes in kidney transplant recipients. In patients with AMR, epitope mismatch was also examined for each class II HLA mismatch to determine development of de novo donor-specific antibodies (DSAs). METHODS: We conducted a retrospective study of 167 kidney recipients. The numbers of eplet mismatches were compared between those with (n = 12) and without (n = 155) AMR, and the numbers of eplet mismatches for each type of mismatch in class II HLA among the AMR patients was also compared...
October 2018: Transplantation Proceedings
K Hata, J Iizuka, Y Hashimoto, T Takagi, T Kondo, K Omoto, T Shimizu, M Okumi, M Inui, H Ishida, K Tanabe
INTRODUCTION: With the increasing number of elderly kidney donor candidates due to the lack of available donors, prostate cancer has sometimes been detected in these candidates during pretransplant screening examinations. There are currently no guidelines or consensus on prostate cancer screening and treatment in donors. We retrospectively evaluated the clinical course of donor candidates with prostate cancer. METHODS: Between January 2006 and December 2016, 9 donor candidates for living related kidney transplantation were incidentally diagnosed with prostate cancer at our institution...
October 2018: Transplantation Proceedings
Tomonori Hirashima, Yoshitaka Tamura, Yuki Han, Shoji Hashimoto, Ayako Tanaka, Takayuki Shiroyama, Naoko Morishita, Hidekazu Suzuki, Norio Okamoto, Shinobu Akada, Makoto Fujishima, Yoshihisa Kadota, Kazuya Sakata, Akiko Nishitani, Satoru Miyazaki, Takayuki Nagai
BACKGROUND: In our previous study, colorectal cancer (CRC) patients with active Mycobacterium tuberculosis (MTB) tolerated concurrent anti-cancer chemotherapy (anti-CCT) and anti-MTB chemotherapy. In this study, we retrospectively confirmed the efficacy and safety of concurrent chemotherapy in a greater number of patients with different types of malignancies. METHODS: We enrolled 30 patients who were treated concurrently with anti-CCT and anti-MTB regimens between January 2006 and February 2016...
October 12, 2018: BMC Cancer
Kentaro Meguro, Ryota Kakizaki, Takuya Hashimoto, Tomoyoshi Yanagisawa, Toshimi Koitabashi, Tadashi Kitamura, Junya Ako
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is effective in treating severe aortic stenosis in inoperable or high-risk surgical patients, however, the little is known about outcomes after Sapien 3 20 mm transcatheter heart valve (THV) implantation. The purpose of this study was to investigate the short term outcomes of Sapien 3 20 mm THV implantation in Japanese people with a small body size. METHODS: We retrospectively collected the hospital records of consecutive patients who underwent TAVI using the Sapien 3 20 mm THV between October 2016 and March 2017...
August 14, 2018: Heart Surgery Forum
Ahmet Kırgız, Kübra Şerefoğlu Çabuk, Mikail Yetmis, Kürşat Atalay
BACKGROUND: Hashimoto's thyroiditis (HT) is an autoimmune endocrine disorder that results from a dysregulation of the immune system leading to an immune attack on the thyroid gland. It has potential effects on different organs and tissues. OBJECTIVES: The aim of the study was to investigate the effect of HT on corneal biomechanical properties using the ocular response analyzer (ORA). MATERIAL AND METHODS: A total of 48 patients with HT and 49 healthy subjects were enrolled in the study...
October 12, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Line Riis Jølving, Jan Nielsen, Ulrik Schiøler Kesmodel, Rasmus Gaardskær Nielsen, Bente Mertz Nørgård, Signe Sparre Beck-Nielsen
Objective: Maternal thyroid disease (TD) during pregnancy is associated with adverse birth outcomes, but little is known on its long-term outcomes. We aimed to examine if children born to mothers with TD have increased disease risk during childhood and adolescence. Patients and methods: A register-based cohort study was conducted on all live born children in Denmark from 1989 to 2013, including the association between maternal TD during pregnancy and somatic and psychiatric diseases in the children...
2018: Clinical Epidemiology
Takahiro Saito, Kenzo Tsuzuki, Hiroki Nishikawa, Ken Okazaki, Kengo Hashimoto, Masafumi Sakagami
OBJECTIVES: We aimed to verify the usefulness of our proposed nasal symptom questionnaire (NSQ) scoring system and to determine predictors linked to the improvement in nasal symptoms in chronic rhinosinusitis (CRS) patients undergoing endoscopic sinus surgery (ESS). PATIENTS AND METHODS: Ninety-one CRS patients undergoing ESS and 144 volunteers with results of NSQ available were enrolled. The NSQ consists of 10 items. Receiver-operating-characteristic (ROC) curve, area under the ROC curve (AUC), internal consistency, and test-retest reproducibility of the NSQ were analyzed...
October 11, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
Marija Lješević, Gordana Gojgić-Cvijović, Teruyo Ieda, Shunji Hashimoto, Takeshi Nakano, Sandra Bulatović, Mila Ilić, Vladimir Beškoski
Polycyclic aromatic hydrocarbons (PAHs) from petroleum and fossil fuels are one of the most dominant pollutants in the environment. Since aromatic fraction from petroleum diesel fuel is mainly composed of PAHs, it is important to discover new microorganisms that can biodegrade these compounds. This article describes the biodegradation of the aromatic fraction separated from petroleum diesel fuel using the strain Oerskovia sp. CHP-ZH25 isolated from petroleum oil-contaminated soil. The biodegradation was monitored by gravimetry and GC × GC-TOF MS...
October 3, 2018: Journal of Hazardous Materials
Takanobu Okamoto, Ryota Kobayashi, Yuto Hashimoto, Kazunori Nosaka
This study compared changes in brachial-ankle pulse wave velocity (baPWV) after concentric (CON) versus eccentric cycling (ECC). It was hypothesized that baPWV would increase after the first ECC bout (ECC1) because of muscle damage, but not after the second ECC bout (ECC2), and would decrease after CON. Fifteen young (20-30 y) men performed two bouts of 30-min ECC (ECC1 and ECC2) at 60% of maximal CON power output and two bouts of 30-min CON at the same intensity as that of ECC (CON1), and at the same oxygen consumption as that of ECC (CON2) every two weeks...
October 11, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Jun Wei, Anantha Marisetty, Brett Schrand, Konrad Gabrusiewicz, Yuuri Hashimoto, Martina Ott, Zacharia Grami, Ling-Yuan Kong, Xiaoyang Ling, Hillary G Caruso, Shouhao Zhou, Y Alan Wang, Gregory N Fuller, Jason T Huse, Eli Gilboa, Nannan Kang, Xingxu Huang, Roel Verhaak, Shulin Li, Amy B Heimberger
Glioblastoma is highly enriched with macrophages, and osteopontin (OPN) expression levels correlate with glioma grade and the degree of macrophage infiltration, thus we studied whether OPN plays a crucial role in immune modulation. Quantitative PCR, immune blotting, and ELISA were used to determine OPN expression. Knockdown of OPN was achieved using complementary siRNA, shRNA and CRISPR/CAS9 techniques followed by a series of in vitro functional migration and immunological assays. OPN gene-deficient mice were used to examine the roles of non-tumor-derived OPN on survival of mice harboring intracranial gliomas...
October 11, 2018: Journal of Clinical Investigation
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