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Soonie Lee, Min Seong Baek, Young Mock Lee
PURPOSE: Previous studies have shown that neurologic symptoms are dominant in patients with mitochondrial diseases, and most of these patients have seizure-related disorders. The epileptic classification of these patients as Lennox-Gastaut syndrome (LGS) is as high as 25%. This study aimed to investigate the clinical manifestations, diagnoses, treatments, and epilepsy in LGS, which is associated with mitochondrial disease. MATERIALS AND METHODS: A retrospective study was conducted on 372 patients who were diagnosed with mitochondrial disease between 2006 and 2016...
January 2019: Yonsei Medical Journal
Min Seong Baek, Se Hoon Kim, Young Mock Lee
PURPOSE: The disease entity mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is characterized by an early onset of stroke-like episodes. MELAS is the most dominant subtype of mitochondrial disease. Molecular genetic testing is important in the diagnosis of MELAS. The mitochondrial DNA (mtDNA) 3243A>G mutation is found in 80% of MELAS patients. Nevertheless, molecular analysis alone may be insufficient to diagnose MELAS because of mtDNA heteroplasmy...
January 2019: Yonsei Medical Journal
Bun Kim, Byung Chang Kim, Jeongseon Kim, Hyun Jin Oh, Kum Hei Ryu, Bum Joon Park, Dae Kyung Sohn, Chang Won Hong, Kyung Su Han
PURPOSE: Prior abdomino-pelvic (AP) surgery makes colonoscopy difficult and can affect bowel preparation quality. However, bowel preparation quality has been found to vary according to prior AP surgery type. We examined the relationship of prior AP surgery type with bowel preparation quality in a large-scale retrospective cohort. MATERIALS AND METHODS: In the health screening cohort of the National Cancer Center, 12881 participants who underwent screening or surveillance colonoscopy between June 2007 and December 2014 were included...
January 2019: Yonsei Medical Journal
Ko Eun Kim, Pil Sung Yang, Eunsun Jang, Sungjin Kim, Boyoung Joung
PURPOSE: Antithrombotic therapy could be related with nuisance bleeding. This study investigated whether vitreous hemorrhage (VH) is associated with specific types of antithrombotic medication in patients with atrial fibrillation (AF). MATERIALS AND METHODS: In the Korean National Health Insurance Service National Sample Cohort, we identified 9352 antiplatelet/anticoagulant-treated AF patients. The occurrence of VH was compared between warfarin (n=1493) and a propensity score (PS)-matched antiplatelet group (n=1493) and between warfarin (n=1493) and a PS-matched warfarin+antiplatelet group (n=1493)...
January 2019: Yonsei Medical Journal
Faris Almarzouqi, Hans-Oliver Rennekampff, Musab Almarzouki, Andreas Lambertz, Metesh Acharya, Christian Klink, Aron-Frederik Popov, Norbert Pallua
During the last three decades, tissue engineering and reconstructive surgery have become standard therapeutic options in the world of medicine. Several biomaterials, either alone, or in combination with cultured cellular products, have been introduced to compensate for the scarcity of autologous donor tissue or to improve healing in a variety of surgical specialties e.g. abdominal/visceral surgery, plastic surgery, cardiovascular surgery and others. Many of these biomaterials are of porcine origin. It is well known that Islam has prohibited the consumption of porcine or any of its products...
December 16, 2018: Journal of Tissue Engineering and Regenerative Medicine
Quoc C Tran, Merrilyn Banks, Thi N D Do, Danielle Gallegos, Mary Hannan-Jones
AIM: Low-dietary intake is a common problem and cause of malnutrition during hospitalisation. This study aims to determine the current dietary intake and food sources of hospitalised adults in Ho Chi Minh City. METHODS: Participants were adult patients from six general public hospitals in a multi-site survey undertaken in 2016. Dietary intakes for all foods consumed in the previous day were collected via interview using the 24 hours recall method. Nutritional status was assessed using Subjective Global Assessment or BMI...
December 16, 2018: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
Bertram Richter, Jeff Bergman, James Pierre, Nestor D Tomycz
Loin Pain Hematuria Syndrome (LPHS) is a rare condition characterized by cryptogenic debilitating flank pain and microscopic or macroscopic hematuria. The pathophysiology of LPHS remains poorly understood and diagnosis is made largely by exclusion of alternate pathology. Management strategies can vary widely and include chronic opioid medication and a variety of invasive procedures including regional nerve blocks, transcutaneous electrical nerve stimulation, local capsaicin infusion, and surgical renal denervation...
December 16, 2018: Pain Practice: the Official Journal of World Institute of Pain
E M Dogan-Guner, H Mohamed, N Orbey, N Goodyear
AIMS: Hydrogen peroxide (H2 O2 ) disinfection applications are limited by its rapid inactivation. The aims of this study were to 1) microencapsulate H2 O2 in silica hydrogels to obtain controlled release up to 72 hours, 2) test hydrogel antimicrobial activity against four common pathogens, and 3) assess H2 O2 release kinetics and antimicrobial activity in 35 - 65% relative humidity and 37°C to approximate bandaged wound conditions. METHODS AND RESULTS: Hydrogels were characterized using scanning electron microscopy, nitrogen sorption porosimetry, Brunauer Emmet Teller analysis, and the Barret - Joyner - Halenda method...
December 16, 2018: Journal of Applied Microbiology
Anthony J King, Anupa Shah, Eleni Nikita, Kuang Hu, Caroline A Mulvaney, Richard Stead, Augusto Azuara-Blanco
BACKGROUND: Glaucoma is a leading cause of irreversible blindness. Subconjunctival draining minimally-invasive glaucoma devices such as the Xen gelatin implant and InnFocus stent have been introduced as a treatment to prevent glaucoma progressing.These implants provide a channel to allow aqueous humour from the anterior chamber of the eye to drain into the subconjunctival space on the surface of the eye thus reducing intraocular pressure (IOP) and mimicking the mechanism of the most commonly undertaken glaucoma surgery, trabeculectomy...
December 16, 2018: Cochrane Database of Systematic Reviews
Vanessa Schieferbein, Judith Bredemann, R Schmitt, I Stenin, T Klenzner, Jörg Schipper, Julia Kristin
PURPOSE: With the increasing use of new minimally invasive approaches in temporal bone surgery, the need arises for evaluation of the risk of injury to sensitive anatomical structures. The factors that influence the measurement uncertainty (variation in representation of position and shape of anatomical structures) of imaging are of relevance. We investigate the effect of patients' anatomy on the measurement uncertainty of medical CT. METHODS: Six formalin-fixed temporal bones were used, fiducial markers were bone-implanted, and 20 CT scans of each temporal bone were generated...
December 15, 2018: European Archives of Oto-rhino-laryngology
Lei Zhang, Xiaoguang Guo, Yang Liu, Min Ou, Xiaoyan Lin, Ji Qi, Yanxiao Xu, Guoyou Wang, Shijie Fu
PURPOSE: The aims of this study had been to classify the superior angle of the scapula based on morphological features, and to investigate its correlation with the suprascapular notch. METHODS: 303 samples of Chinese dried scapular specimens were collected from the Department of anatomy, Southwest Medical University. According to the anatomical morphological characteristics of the superior angle of the scapula, the morphological classification was performed to explore its correlation with the suprascapular notch (SSN)...
December 15, 2018: Surgical and Radiologic Anatomy: SRA
Jean M Abraham, Anne B Royalty, Coleman Drake
Using the 2010-2015 Medical Expenditure Panel Survey-Insurance Component, this study investigates the effect of the Affordable Care Act's Medicaid eligibility expansion on four employer-sponsored insurance (ESI) outcomes: offers of health insurance, eligibility, take-up, and the out-of-pocket premium paid by employees for single coverage. Using a difference-in-differences identification strategy, we cannot reject the hypothesis of a zero effect of the Medicaid eligibility expansion on an establishment's probability of offering ESI, the percentage of an establishment's workforce that takes up coverage, or the out-of-pocket premium for single coverage...
December 15, 2018: International Journal of Health Economics and Management
C Couffignal, J Bertrand, S Sportiche, Marine Jarroir, S El Balkhi, N Djebrani-Oussedik, J Poupon, X Declèves, F Mentré, F Bellivier
PURPOSE: Lithium (Li), the first-line treatment of bipolar disorder, was first developed as an immediate-release form with a routine therapeutic drug monitoring 12 h after the last dose. In Europe, the most commonly prescribed form is a sustained release (srLi). Yet no pharmacokinetics (PK) study has been published of srLi, administered once a day, in adults. The present study describes srLi PK in the serum and erythrocytes of bipolar patients. METHODS: To assess srLi PK, we studied prospectively 17 French bipolar patients on a median dose of 1000 mg (600-1600) for at least 2 years...
December 15, 2018: European Journal of Clinical Pharmacology
Konstantinos Markatos, Georgios Androutsos, Marianna Karamanou, Maria Kaseta, Demetrios Korres, Andreas Mavrogenis
AIM OF THE STUDY: The purpose of this historic review is to summarize the life and work of Avicenna (980-1037) and his contribution to the diagnosis and treatment of spinal deformities and trauma. METHOD: We conducted an extensive search in libraries as well as online in Pubmed and Google Scholar. RESULTS: Avicenna in his work Canon of Medicine combines the knowledge of ancient Greek and Roman physicians and surgeons and he combines them with the extensive of Arabic medicine and pharmacology...
December 15, 2018: International Orthopaedics
Takerra Johnson, Lina Zhao, Gygeria Manuel, Herman Taylor, Dong Liu
Ischemic heart disease (IHD) is caused by the narrowing of arteries that work to provide blood, nutrients, and oxygen to the myocardial tissue. The worldwide epidemic of IHD urgently requires innovative treatments despite the significant advances in medical, interventional, and surgical therapies for this disease. Angiogenesis is a physiological and pathophysiological process that initiates vascular growth from pre-existing blood vessels in response to a lack of oxygen. This process occurs naturally over time and has encouraged researchers and clinicians to investigate the outcomes of accelerating or enhancing this angiogenic response as an alternative IHD therapy...
December 15, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Harmony I Risca, Lisa E Baker
RATIONALE: 3,4-Methylenedioxypyrovalerone (MDPV) is a popular synthetic cathinone reported to have a high abuse potential. Recent preclinical research indicates the psychopharmacology of MDPV is comparable to cocaine. Despite a recent influx of research on the psychopharmacology of MDPV, few studies have employed preclinical drug discrimination methods to discern the neurochemical mechanisms involved in its interoceptive stimulus effects. OBJECTIVE: The aim of this study was to evaluate a variety of monoaminergic agents for substitution, potentiation, or antagonism in rats trained to discriminate MDPV...
December 15, 2018: Psychopharmacology
B Mazzariol, M Karaboue, A Di Luca, N M Di Luca
Enactment of law n. 24, 8th March 2017, (so-called "Gelli-Bianco" law), has given rise to substantial innovations in the realm of medical liability: on the one hand, an attempt has been made towards redefining the boundaries of professional liability, for the purpose of curbing the use of "defensive medicine"; on the other hand, there is the effort to delineate good medical conduct by means of "institutionalization" and a greater degree of consistency of guidelines and good clinical health care practices...
November 2018: La Clinica Terapeutica
B S Kalani, F Khodaei, M Moghadampour, L Lotfollahi, E Ohadi, M Foroozeshfard, A Shivaee, G Irajian
BACKGROUND: As a great opportunistic pathogen, Staphylococcus epidermidis participates in a wide spectrum of infections by residing in the medical devices. Regardless of the clinical importance of S. epidermidis, there are a few data about typing of clinical and non-clinical isolates at the subspecies level in Iran. We used the technique of "Multiple-Locus Variable number tandem repeat Analysis" for genetic differentiation of 107 clinical and non-clinical S. epidermidis isolates...
January 2019: Annali di Igiene: Medicina Preventiva e di Comunità
E Alagna, O E Santangelo, D D Raia, V Gianfredi, S Provenzano, A Firenze
INTRODUCTION: In Italy, as in the rest of the world, the number of homeless people is increasing considerably. Many of them suffer from chronic conditions, mental health problems and addiction to alcohol, drugs or smoking, and need complex medical care. Their health status is often exacerbated by greater difficulty in accessing primary care. The aim of the present study was to assess health conditions of homeless people living in Palermo, Southern Italy, and to find ways to limit the spread of common infectious diseases that can be prevented by vaccination...
January 2019: Annali di Igiene: Medicina Preventiva e di Comunità
M L Ciofi Degli Atti, C D'Amore, C Gagliotti, C Zotti, E Ricchizzi, M L Moro, M Raponi
BACKGROUND: Antimicrobial stewardship programs and comprehensive infection control programs represent the main strategies to limit the emergence and transmission of multi-drug resistant bacteria in hospital settings. The purpose of this study was to describe strategies implemented in Italian children's hospitals for controlling antibiotic resistance. STUDY DESIGN: Cross sectional multicenter study. METHODS: Four tertiary care Italian children's hospitals were invited to participate in a survey aimed at collecting information on activities implemented as of December 2015 using a self-administered online questionnaire...
January 2019: Annali di Igiene: Medicina Preventiva e di Comunità
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