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https://www.readbyqxmd.com/read/29036792/are-helicobacter-pylori-highly-cytotoxic-genotypes-and-cardia-gastric-adenocarcinoma-linked-lessons-from-iran
#1
Seyedeh Zahra Bakhti, Saeid Latifi-Navid, Saber Zahri, Fatemeh Sadat Bakhti, Naser Hajavi, Abbas Yazdanbod
BACKGROUND: Although the most extensive studies revealed the role of H. pylori VacA and CagA toxins in the development of gastric adenocarcinoma, the magnitude of this association and the correlations of vacA mosaicism and cagA status with cardia gastric adenocarcinoma (CGA) still remain controversial. OBJECTIVE: We aimed to examine the linkage of H. pylori highly cytotoxic genotypes to CGA in Iranian populations as a model. METHODS: A total of 601 Iranian patients were enrolled...
September 29, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29036784/decreased-expression-of-lncrna-vps9d1-as1-in-gastric-cancer-and-its-clinical-significance
#2
Min Chen, Xiaoliang Wu, Wenjuan Ma, Qianghua Zhou, Xing Wang, Rongxin Zhang, Jiahong Wang, Xianzi Yang
BACKGROUND: A recent study has demonstrated that the long non-coding RNA VPS9D1-AS1 is highly expressed in colorectal cancer and predicts poor prognosis. However, role of VPS9D1-AS1 in gastric cancer remained poorly understood. OBJECTIVE: The aim of this study is to decipher the expression of VPS9D1-AS1 in gastric cancer (GC) patients, so as to assess whether or not it could be used as a novel biomarker for prognosis in gastric cancer patients. METHODS: The expression of VPS9D1-AS1 was examined in cancer tissues and paired adjacent non-tumorous tissues from 126 gastric cancer patients using qRT-PCR...
September 29, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29036438/a-selective-sphingosine-1-phosphate-receptor-1-agonist-sew-2871-aggravates-gastric-cancer-by-recruiting-myeloid-derived-suppressor-cells
#3
Yujing Zhou, Feng Guo
The immune status of tumor microenvironment in gastric cancer is poorly understood, which limits the development of novel strategies in this field. Sphingosine-1-phosphate (S1P) acts as an immune modulator, but the role of S1P in gastric cancer is elusive. Here, we aim to investigate S1P receptor 1 (S1P1)-mediated effect of S1P in gastric cancer. We generated a xenograft mouse model and used SEW-2871, a S1P1 specific agonist to activate S1P1 signaling. Tumor-infiltrating lymphocytes (TILs) were isolated and analyzed using flow cytometry...
October 3, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29036264/immature-colon-carcinoma-transcript-1-promotes-proliferation-of-gastric-cancer-cells
#4
Zishu Wang, Gongsheng Jin, Qiong Wu, Rui Wang, Yumei Li
Gastric cancer is the fourth most common malignant tumor and has been considered as one of the leading causes of cancer-related death worldwide. The identification of the molecular mechanism during gastric cancer progression is urgently needed, which will help to develop more effective treatment strategies. As a component of the human mitoribosome, immature colon carcinoma transcript-1 (ICT1) might be involved in tumor formation and progression. However, its biological function and the corresponding mechanism in gastric cancer have been poorly characterized...
October 3, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29035829/mir-129-inhibits-cell-proliferation-and-metastasis-by-targeting-ets1-via-pi3k-akt-mtor-pathway-in-prostate-cancer
#5
Song Xu, Jingping Ge, Zhengyu Zhang, Wenquan Zhou
New evidence suggests that microRNAs (miRNAs) play an important role in regulating the development and progression of prostate cancer. However, their specific functions and mechanisms remained to be further explored. MiR-129 has been reported in gastric cancers, colon cancer and lung cancer. In this study, we disclosed a new tumor suppresser function of miR-129 in prostate cancer. The purpose of our study is to clarify the effects of miR-129 in cellular processes correlated with cancer development and progression of prostate cancer cell by regulating ETS1...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29034543/pd-l1-expression-is-mainly-regulated-by-ifn-%C3%AE-associated-with-jak-stat-pathway-in-gastric-cancer
#6
Kousaku Mimura, Jun Liang Teh, Hirokazu Okayama, Kensuke Shiraishi, Ley-Fang Kua, Vivien Koh, Duane T Smoot, Hassan Ashktorab, Takahiro Oike, Yoshiyuki Suzuki, Zul Fazreen, Bernadette R Asuncion, Asim Shabbir, Wei-Peng Yong, Jimmy So, Richie Soong, Koji Kono
Despite multidisciplinary treatment for patients with advanced gastric cancer, their prognosis still remains poor. Therefore, the development of novel therapeutic strategies is urgently needed, and immunotherapy utilizing anti-programmed death 1/-programmed death ligand-1 mAb is an attractive approach. However, as there is limited information on how programmed death ligand-1 is upregulated on tumor cells within the tumor microenvironment, we examined the mechanism of programmed death ligand-1 regulation with a particular focus on interferon gamma in in-vitro setting and in clinical samples...
October 16, 2017: Cancer Science
https://www.readbyqxmd.com/read/29033776/carbohydrate-antigen-19-9-positive-gastric-adenocarcinoma-autopsy-findings-and-review-of-the-literature
#7
Tan Wang, Yoko Matsuda, Atsuko Seki, Keisuke Nonaka, Mototsune Kakizaki, Daita Kaneda, Junko Takahashi-Fujigasaki, Shigeo Murayama, Tomio Arai
Carbohydrate antigen 19-9 (CA19-9) is a well-known tumor marker for pancreatobiliary cancer, and several studies have shown that an elevated serum CA19-9 level is associated with more aggressive biological behavior in gastric cancer (GC). However, the clinicopathological characteristics of CA19-9-positive GC remain unclear. We herein report an autopsy case of CA19-9-positive GC in an 84-year-old man who was admitted to our hospital because of paralysis and anemia. Autopsy revealed an ulcerative-invasive tumor measuring 72 × 60 mm in the anterior wall of the gastric body...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29033591/clinicopathological-features-and-prognoses-in-younger-and-older-patients-with-gastric-cancer
#8
Shubin Song, Chunfeng Li, Sen Li, Xiliang Cong, Yingwei Xue
BACKGROUND AND OBJECTIVES: Patients of different ages with gastric cancer (GC) have different clinicopathological features and prognoses. The results for different crowds are limited and controversial. The aim of this study was to investigate the differences in clinicopathological features and prognoses between younger and older GC patients. METHODS: From January 2007 to December 2011, a consecutive total of 112 GC patients under 41 years old and 358 GC patients over 69 years old who underwent gastrectomy for GC were recruited for this study...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29033568/in-vivo-evaluation-of-cetuximab-conjugated-poly-%C3%AE-glutamic-acid-docetaxel-nanomedicines-in-egfr-overexpressing-gastric-cancer-xenografts
#9
Maya Sreeranganathan, Saji Uthaman, Bruno Sarmento, Chethampadi Gopi Mohan, In-Kyu Park, Rangasamy Jayakumar
Epidermal growth factor receptor (EGFR), upregulated in gastric cancer patients, is an oncogene of interest in the development of targeted cancer nanomedicines. This study demonstrates in silico modeling of monoclonal antibody cetuximab (CET MAb)-conjugated docetaxel (DOCT)-loaded poly(γ-glutamic acid) (γ-PGA) nanoparticles (Nps) and evaluates the in vitro/in vivo effects on EGFR-overexpressing gastric cancer cells (MKN-28). Nontargeted DOCT-γ-PGA Nps (NT Nps: 110±40 nm) and targeted CET MAb-DOCT-γ-PGA Nps (T Nps: 200±20 nm) were prepared using ionic gelation followed by 1-Ethyl-3-(3-dimethyl aminopropyl)carbodiimide-N-Hydoxysuccinimide (EDC-NSH) chemistry...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29032577/pyruvate-kinase-isozymes-m2-and-glutaminase-might-be-promising-molecular-targets-for-the-treatment-of-gastric-cancer
#10
Kishu Kitayama, Masakazu Yashiro, Tamami Morisaki, Yuichiro Miki, Tomohisa Okuno, Haruhito Kinoshita, Tatsunari Fukuoka, Hiroaki Kasashima, Go Masuda, Tsuyoshi Hasegawa, Katsunobu Sakurai, Naoshi Kubo, Kosei HIrakawa, Masaichi Ohira
The aim of this study was to analyze the significance of glucose metabolism-related enzymes in the proliferation of gastric cancer under hypoxia. Four hypoxia-resistant gastric cancer cell lines and 4 parent cell lines were used. RT-PCR was used to evaluate the mRNA expression levels of the following metabolism-related enzymes: pyruvate kinase isozymes M2 (PKM2), glutaminase (GLS), enolase 1 (ENO1), glucose-6-phosphate dehydrogenase (G6PDH), and PKM1. The effects of these enzymes on the proliferation of gastric cancer cells were examined using siRNAs, Shikonin as a PKM2 inhibitor, or BPTES as a GLS inhibitor, in vitro and in vivo...
October 15, 2017: Cancer Science
https://www.readbyqxmd.com/read/29032071/comparing-intestinal-versus-diffuse-gastric-cancer-using-a-peff-oriented-proteomic-pipeline
#11
Helisa Helena Wippel, Marlon Dias Mariano Santos, Milan Avila Clasen, Louise Ulrich Kurt, Fabio Cesar Sousa Nogueira, Carlos Eduardo Carvalho, Thaís Messias McCormick, Guilherme Pinto Bravo Neto, Lysangela Ronalte Alves, Maria da Gloria da Costa Carvalho, Paulo Costa Carvalho, Juliana de Saldanha da Gama Fischer
Gastric cancer is the fifth most common malignant neoplasia and the third leading cause of cancer death worldwide. Mac-Cormick et al. recently showed the importance of considering the anatomical region of the tumor in proteomic gastric cancer studies; more differences were found between distinct anatomical regions than when comparing healthy versus diseased tissue. Thus, failing to consider the anatomical region could lead to differential proteins that are not disease specific. With this as motivation, we compared the proteomic profiles of intestinal and diffuse adenocarcinoma from the same anatomical region, the corpus...
October 11, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29031586/complement-c5a-c5ar-pathway-potentiates-the-pathogenesis-of-gastric-cancer-by-down-regulating-p21-expression
#12
Jian Chen, Gui-Qing Li, Li Zhang, Ming Tang, Xu Cao, Gui-Lian Xu, Yu-Zhang Wu
Although the complement C5a/C5aR pathway is suggested to play a critical role in tumor pathogenesis, the underlying mechanism has yet to be fully elucidated. In the present study, we found that in patients with gastric cancer in different clinical stages (from stageⅠto stage Ⅳ), both C5aR and p-PI3K/AKT levels were significantly higher in tumoral tissues than in adjacent non-tumoral tissues. In contrast, p21/p-p21 levels were significantly lower in tumoral tissues than in adjacent non-tumoral tissues. In vitro recombinant C5a administration remarkably promoted p-PI3K/p-AKT expression, but inhibited p21/p-p21 expression...
October 11, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29031176/a-case-of-dedifferentiated-liposarcoma-of-the-heart-and-stomach
#13
Yoichi Hisata, Yuichi Tasaki, Satoshi Kozaki, Takafumi Yamada
INTRODUCTION: Liposarcoma of the heart and stomach is rare. PRESENTAION OF CASE: We report a case of liposarcoma in both organs with dedifferentiated histology. A patient was referred to our hospital with anorexia and weight loss. Upper gastrointestinal tract endoscopy revealed 5-10-mm elevated lesions, and echocardiography and computed tomography showed tumorous lesions in the left atrium. Tumor resection and mitral valve replacement were performed, and biopsy was performed for the gastric tumor...
October 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29029529/the-roles-of-maspin-expression-in-gastric-cancer-a-meta-and-bioinformatics-analysis
#14
Hua-Chuan Zheng, Bao-Cheng Gong
Maspin is a mammary serine protease inhibitor that is encoded by human SERPINB5 gene, and inhibits invasion and metastasis of cancer cells as a tumor suppressor. We performed a systematic meta- and bioinformatics analysis through multiple online databases up to Feb 10, 2017. We found down-regulated maspin expression in gastric cancer, compared with normal mucosa and dysplasia (p < 0.05). Maspin expression was negatively correlated with depth of invasion, TNM staging and dedifferentiation of gastric cancer (p < 0...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029513/development-of-mesenchymal-subtype-gene-signature-for-clinical-application-in-gastric-cancer
#15
Jeeyun Lee, Razvan Cristescu, Kyoung-Mee Kim, Kyung Kim, Seung Tae Kim, Se Hoon Park, Won Ki Kang
Previously, in the Asian Cancer Research Group (ACRG) project, we defined four distinct molecular subtypes in gastric cancer (GC). Mesenchymal (microsatellite stable with epithelial-to-mesenchymal transition phenotype, MSS/EMT) tumors showed the worst prognosis among all the subtypes. To develop a gene signature for predicting mesenchymal subtype GC, we conducted gene expression profiling using a NanoString assay in 70 ACRG specimens. The gene signature was validated in an independent set obtained from the prospective Adjuvant chemoRadioTherapy In Stomach Tumor (ARTIST) trial...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029429/twist1-is-highly-expressed-in-cancer-associated-fibroblasts-of-esophageal-squamous-cell-carcinoma-with-a-prognostic-significance
#16
So-Young Yeo, Sang-Yun Ha, Keun-Woo Lee, Yan Cui, Zhao-Ting Yang, Yan-Hua Xuan, Seok-Hyung Kim
Cancer-associated fibroblasts (CAFs) play important roles in cancer progression. Twist1 was recently reported to be a key regulator of CAFs in gastric cancer, but its role in other types of cancer remains unclear, especially for esophageal squamous cell carcinoma (ESCC). We assessed the Twist1 expression on stromal fibroblasts using immunohistochemistry in 169 tissue specimens from ESCC patients, and performed in vitro and in vivo experiments to confirm the role of Twist1 in CAFs of ESCC. And we investigated the biological pathways that are activated in Twist1-high ESCC using The Cancer Genome Atlas (TCGA) data...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029421/prognostic-value-of-supraclavicular-nodes-and-upper-abdominal-nodes-metastasis-after-definitive-chemoradiotherapy-for-patients-with-thoracic-esophageal-squamous-cell-carcinoma
#17
Xue Li, Lujun Zhao, Wencheng Zhang, Chengwen Yang, Zhen Lian, Shuai Wang, Ningbo Liu, Qingsong Pang, Ping Wang, Jinming Yu
The purpose of this study is to assess the prognostic value of supraclavicular nodes, left gastric nodes, celiac nodes and common hepatic nodes metastasis in esophageal squamous cell carcinoma (ESCC) treated with definitive radiotherapy. A total of 293 ESCC patients treated with radiotherapy or chemoradiotherapy entered the study. The results showed that the presence of supraclavicular nodes (χ(2) = 0.075, P = 0.785) and left gastric nodes (χ(2) = 3.603, P = 0.058) metastasis had no significant influence on survival, while celiac nodes (χ(2) = 33...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028942/association-of-high-evidence%C3%A2-gastric-cancer%C3%A2-susceptibility-loci-and-somatic-gene-expression-levels-with-survival
#18
Hyuna Sung, Nan Hu, Howard H Yang, Carol A Giffen, Bin Zhu, Lei Song, Hua Su, Chaoyu Wang, Dominick M Parisi, Alisa M Goldstein, Philip R Taylor, Paula L Hyland
Eleven high-evidence single-nucleotide polymorphisms (SNPs) at 9 loci for gastric cancer (GC) risk were reported, but their associations with survival remains unknown. In this study, we examined associations between SNP and GC survival by anatomic location and histology among 1147 incident cases from the Shanxi Upper Gastrointestinal Genetics Project. We further examined if SNPs were expression quantitative trait loci (eQTL) in normal and tumor gastric tissues, and whether tumor vs. normal somatic mRNA differences in 126 cases were associated with survival...
September 27, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29028095/bcar4-increase-cisplatin-resistance-and-predicted-poor-survival-in-gastric-cancer-patients
#19
L Wang, Q Chunyan, Y Zhou, Q He, Y Ma, Y Ga, X Wang
OBJECTIVE: Gastric cancer is a common malignancy with increasing worldwide incidence, and chemotherapeutic drugs for gastric cancer are not effective. Long non-coding RNA (lncRNA) has been proved to be important in different cancer progression. In this research, we investigated whether lncRNAs have relations with drug resistance in gastric cancer to find new potential targets for therapy, which can increase the survival time of the drug-resistant gastric patient. PATIENTS AND METHODS: qRT-PCR was used to detect the expression of BCAR4 in 113 cases of gastric cancer tissue and adjacent tissue, and the clinical significance was also analyzed...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29028094/upregulation-of-mir-802-suppresses-gastric-cancer-oncogenicity-via-targeting-rab23-expression
#20
X-Y Zhang, J-H Mu, L-Y Liu, H-Z Zhang
OBJECTIVE: The aberrant expression of microRNAs (miRNAs) has been observed in various types of cancer. Recently, miR-802 was found to play important role in tumor progression. However, the function of miR-802 in gastric cancer (GC) remains unknown. The aim of the present study was to investigate biological effects and underlying mechanisms of miR-802 in GC. PATIENTS AND METHODS: Quantitative RT-PCR was performed to evaluate the expression level of miR-802 in GC tissues and cell lines...
September 2017: European Review for Medical and Pharmacological Sciences
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