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https://www.readbyqxmd.com/read/29470693/anti-inflammatory-anti-rheumatic-and-analgesic-activities-of-2-5-mercapto-1-3-4-oxadiazol-2-yl-n-propylbenzenesulphonamide-mopbs-in-rodents
#1
Hina Rasheed, Ruqayya Afridi, Ashraf Ullah Khan, Muhammad Zia Ullah, Sidra Khalid, Ayesha Atiq, Humaira Kashif, Muhammad Naeem Ahmed, Yeong Shik Kim, Salman Khan
Chronic inflammation is pathologically associated with various clinical conditions such as rheumatoid arthritis. Several anti-inflammatory and analgesic drugs currently available in market presents a wide range of problems. Therefore, the current study was aimed to evaluate anti-inflammatory and analgesic activities of newly synthesized compound 2-(5-mercapto-1,3,4-oxadiazol-2-yl)-N-propylbenzenesulphonamide (MOPBS). Carrageenan and CFA-induced models were developed for evaluation of anti-inflammatory and analgesic activity...
February 22, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29470296/plexiform-fibromyxoma-a-rare-benign-gastric-tumor
#2
Zlatko Djurić, Zorica Stojšić, Spasoje Radulović, Radmila Janković, Ivana Savić Milovanović
No abstract text is available yet for this article.
February 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29468422/molecular-profiling-and-comprehensive-genome-wide-analysis-of-somatic-copy-number-alterations-in-gastric-intramucosal-neoplasias-based-on-microsatellite-status
#3
Tamotsu Sugai, Makoto Eizuka, Noriyuki Arakawa, Mitsumasa Osakabe, Wataru Habano, Yasuko Fujita, Eiichiro Yamamoto, Hiroo Yamano, Masaki Endoh, Takayuki Matsumoto, Hiromu Suzuki
BACKGROUND: We attempted to identify the molecular profiles of gastric intramucosal neoplasia (IMN; low-grade dysplasia, LGD; high-grade dysplasia, HGD; intramucosal cancer, IMC) by assessing somatic copy number alterations (SCNAs) stratified by microsatellite status (microsatellite stable, MSS; microsatellite instable, MSI). Thus, microsatellite status was determined in 84 tumors with MSS status and 16 tumors with MSI status. METHODS: One hundred differentiated type IMNs were examined using SCNAs...
February 21, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29468062/characterization-of-oncogene-suppressor-marker-expression-in-patients-with-submucosal-gastric-carcinoma
#4
Roberson A Moron, Carlos Eduardo Jacob, Claudio José Caldas Bresciani, Kleber Simões, Venâncio Avancini Ferreira Alves, Kyoshi Irya, Joaquim Gama-Rodrigues, Ivan Cecconello, Adhemar Longatto-Filho, Bruno Zilberstein
The aim of the present study was to determine the clinical significance of p53 and p21ras p21wafl , p27kip1 and p16ink4a expression in cases of early gastric cancer. A total of 81 patients who had undergone gastrectomy with D2 lymphadenectomy between 1971 and 2004 were retrospectively investigated. The immunohistochemical expression of p21ras , p53, p21waf1/cip1 , p27kip1 and p16ink4a in the tissues was evaluated. In normal, metaplastic and tumoral mucosa, p53 was positive in 53, 87.3, and 87.1% of the cases, respectively...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29467883/effects-of-yangzheng-sanjie-decoction-containing-serum-mediated-by-microrna-7-on-cell-proliferation-and-apoptosis-in-gastric-cancer
#5
Wanqun Chen, Yaya Yu, Naikun Yang, Jingli Zhu, Ke Li, Ruocun Li, Wenqiao Su, Lina Luo, Ling Hu, Gengxin Chen, Haixia Deng
Gastric cancer (GC) is one of the most common types of cancer and a leading cause of cancer-associated mortality. MicroRNAs (miRNAs/miRs) are demonstrated to function as oncomiRs or tumor-suppressor-miRs in GC. miR-7 has been identified to be a tumor suppressor of GC by targeting epidermal growth factor receptor (EGFR). In our previous study, Yangzheng Sanjie Decoction (YZSJD), a traditional Chinese formula, was identified to be effective in alleviating the symptoms and even postponing turnover of precancerous lesions...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467878/parthenolide-facilitates-apoptosis-and-reverses-drug-resistance-of-human-gastric-carcinoma-cells-by-inhibiting-the-stat3-signaling-pathway
#6
Hua Li, Hang Lu, Meng Lv, Qingsheng Wang, Yuping Sun
In the present study, SGC-7901/DDP cells were treated with different concentrations of parthenolide (PN) (2.5-15 µmol/l), cisplatin (DDP) (1.25-15 µg/ml) and PN+DDP. The proliferation inhibition rates were measured using an MTT assay, and the synergies of PN and DDP were analyzed. The effect of PN and DDP on SGC-7901/DDP cell proliferation demonstrated a time- and concentration-dependent association, and a synergy between PN and DDP was identified. DAPI staining and flow cytometry results indicated that 15 µmol/l PN significantly induced SGC-7901/DDP apoptosis and G1 phase arrest compared with the untreated control group...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467338/tcr-mimic-bispecific-antibodies-targeting-lmp2a-show-potent-activity-against-ebv-malignancies
#7
Mahiuddin Ahmed, Andres Lopez-Albaitero, Dmitry Pankov, Brian H Santich, Hong Liu, Su Yan, Jingyi Xiang, Pei Wang, Aisha N Hasan, Annamalai Selvakumar, Richard J O'Reilly, Cheng Liu, Nai-Kong V Cheung
EBV infection is associated with a number of malignancies of clinical unmet need, including Hodgkin lymphoma, nasopharyngeal carcinoma, gastric cancer, and posttransplant lymphoproliferative disease (PTLD), all of which express the EBV protein latent membrane protein 2A (LMP2A), an antigen that is difficult to target by conventional antibody approaches. To overcome this, we utilized phage display technology and a structure-guided selection strategy to generate human T cell receptor-like (TCR-like) monoclonal antibodies with exquisite specificity for the LMP2A-derived nonamer peptide, C426LGGLLTMV434 (CLG), as presented on HLA-A*02:01...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29467311/epstein-barr-virus-nuclear-antigen-leader-protein-co-activates-ep300
#8
Chong Wang, Hufeng Zhou, Yong Xue, Jun Liang, Yohei Narita, Catherine Gerdt, Amy Y Zheng, Runsheng Jiang, Stephen Trudeau, Chih-Wen Peng, Benjamin Gewurz, Bo Zhao
Epstein-Barr virus nuclear antigen (EBNA) leader protein (EBNALP) is one of the first viral genes expressed upon B-cell infection. EBNALP is essential for EBV-mediated B cell immortalization. EBNALP is thought to function primarily by co-activaing EBNA2-mediated transcription. Chromatin immune precipitation followed by deep-sequencing (ChIP-seq) studies highlight that EBNALP frequently co-occupies DNA sites with host cell transcription factors (TFs), in particular EP300, implicating a broader role in transcription regulation...
February 21, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29466294/respiratory-gated-proton-beam-therapy-for-hepatocellular-carcinoma-adjacent-to-the-gastrointestinal-tract-without-fiducial-markers
#9
Miu Mizuhata, Shigeyuki Takamatsu, Satoshi Shibata, Sayuri Bou, Yoshitaka Sato, Mariko Kawamura, Satoko Asahi, Yuji Tameshige, Yoshikazu Maeda, Makoto Sasaki, Tomoyasu Kumano, Satoshi Kobayashi, Kazutaka Yamamoto, Hiroyasu Tamamura, Toshifumi Gabata
The efficacy of proton beam therapy (PBT) for hepatocellular carcinoma (HCC) has been reported, but insertion of fiducial markers in the liver is usually required. We evaluated the efficacy and toxicity of respiratory-gated PBT without fiducial markers for HCC located within 2 cm of the gastrointestinal tract. From March 2011 to December 2015 at our institution, 40 patients were evaluated (median age, 72 years; range, 38-87 years). All patients underwent PBT at a dose of 60 to 80 cobalt gray equivalents (CGE) in 20 to 38 fractions...
February 21, 2018: Cancers
https://www.readbyqxmd.com/read/29466035/inhibition-of-stat6-anoctamin-1-activation-suppresses-proliferation-and-invasion-of-gastric-cancer-cells
#10
Guohao Lu, Wanling Shi, Hongyu Zheng
BACKGROUND: Gastric carcinoma is the most popular cancer worldwide. Anoctamin-1 is a calcium-activated channel and highly expressed in various tumors. A previous study indicated that suppressed Anoctamin-1 expression decreased cancer cell proliferation or migration. As a signal transduction and transcription activator, STAT6 is a novel agonist for Anoctamin-1 promoter. However, its role in tumor cell proliferation or migration remains unclear. Therefore, this study aimed to suppress STAT6 and Anoctamin-1 protein expression in gastric cancer cells to test the inhibitory effects on gastric cancer cell migration or invasion...
February 2018: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29465762/antitumor-activity-of-pan-her-inhibitors-in-her2-positive-gastric-cancer
#11
Takahiro Yoshioka, Kazuhiko Shien, Kei Namba, Hidejiro Torigoe, Hiroki Sato, Shuta Tomida, Hiromasa Yamamoto, Hiroaki Asano, Junichi Soh, Kazunori Tsukuda, Takeshi Nagasaka, Toshiyoshi Fujiwara, Shinichi Toyooka
Molecularly targeted therapy has enabled outstanding advances in cancer treatment. Whereas various anti-HER2 drugs have been developed, trastuzumab is still the only anti-HER2 drug presently available for gastric cancer. In this study, we propose novel treatment options for patients with HER2-positive gastric cancer. At first, we determined the molecular profiles of 12 gastric cancer cell lines, and examined the antitumor effect of the pan-HER inhibitors afatinib and neratinib in those cell lines. Additionally, we analyzed HER2 alteration in 123 primary gastric cancers resected from Japanese patients to clarify possible candidates with the potential to respond to these drugs...
February 21, 2018: Cancer Science
https://www.readbyqxmd.com/read/29464343/prognostic-significance-of-platelet-based-inflammatory-indicators-in-patients-with-gastric-cancer
#12
Hiroaki Saito, Yusuke Kono, Yuki Murakami, Yuji Shishido, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki, Keigo Ashida, Yoshiyuki Fujiwara
BACKGROUND: Thrombocytosis develops in association with malignant tumors and may reflect the inflammation status in cancer patients. This study retrospectively investigated the prognostic significance of two platelet-based inflammatory indicators, the platelet × C-reactive protein multiplier value (P-CRP), and platelet-lymphocyte ratio (PLR), in gastric cancer patients. METHODS: The 453 enrolled patients had a histopathological diagnosis of gastric adenocarcinoma and underwent curative surgery...
February 20, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29464049/inhibition-of-iap-s-and-activation-of-p53-leads-to-caspase-dependent-apoptosis-in-gastric-cancer-cells-treated-with-scutellarein
#13
Venu Venkatarame Gowda Saralamma, Ho Jeong Lee, Suchismita Raha, Won Sup Lee, Eun Hee Kim, Sang Joon Lee, Jeong Doo Heo, Chungkil Won, Chang Keun Kang, Gon Sup Kim
Gastric cancer is the fifth most common cancer and the third leading cause of cancer deaths worldwide. South Korea is in first place with 9,180 death alone attributed to gastric cancer in 2013. Plenty of literature suggests the evasion of apoptosis is implicated in neurodegeneration, autoimmune diseases, and tumors development due to dysregulation in the apoptotic mechanism. Reduced apoptosis or its resistance in cancer cells plays a significant role in carcinogenesis. It's imperative to understand apoptosis, which provides the basis for novel targeted therapies that can induce cancer cell death or sensitize them to cytotoxic agents by regulating key factors like IAPs, MDM2, p53, caspases and much more...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29464048/src-is-the-primary-target-of-aripiprazole-an-atypical-antipsychotic-drug-in-its-anti-tumor-action
#14
Mi Seon Kim, Byong Chul Yoo, Woo Seok Yang, Sang Yun Han, Deok Jeong, Jun Min Song, Kyung Hee Kim, Adithan Aravinthan, Ji Hye Kim, Jong-Hoon Kim, Seung Cheol Kim, Jae Youl Cho
Aripiprazole (ARP) is an atypical anti-psychotic drug widely used to treat schizophrenia and bipolar disorder. The pharmacological effects of ARP on cancer cells are still poorly understood. In this study, anti-cancer effects of ARP on various malignant tumor cells and its molecular mechanism were further carefully examined by using cell proliferation assay, xenograft mouse model, immunoblotting analysis, migration assay, luciferase reporter gene assay, kinase assay, and overexpression strategy. Treatment with ARP induced cytotoxicity in U251 glioma cells, MKN-1 gastric adenosquamous carcinoma cells, and CT26 colon carcinoma cells...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463648/id2-determines-intestinal-identity-through-repression-of-the-foregut-transcription-factor-irx5
#15
Kentaro Mori, Harumi Nakamura, Hisanori Kurooka, Hitoshi Miyachi, Kota Tamada, Manabu Sugai, Toru Takumi, Yoshifumi Yokota
The cellular components and function of the gastrointestinal epithelium exhibit distinct characteristics depending on the region, e.g., stomach or intestine. How these region-specific epithelial characteristics are generated during development remains poorly understood. Here, we report on the involvement of the helix-loop-helix inhibitor Id2 in establishing the specific characteristics of the intestinal epithelium. Id2 -/- mice developed tumors in the small intestine. Histological analysis indicated that the intestinal tumors were derived from gastric metaplasia formed in the small intestine during development...
February 20, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29463236/rapid-symptomatic-relief-of-her2-positive-gastric-cancer-leptomeningeal-carcinomatosis-with-lapatinib-trastuzumab-and-capecitabine-a-case-report
#16
Xiao-Dong Jiao, Chunming Ding, Yuan-Sheng Zang, Guanzhen Yu
BACKGROUND: Gastric cancer patients with widespread metastasis, especially meningeal metastases, have an extremely prognosis and limited therapeutic choices. CASE PRESENTATION: We reported the case of a 39-year-old male patient with HER2-positive gastric cancer with bone and meningeal metastases. He presented with multiple bone metastases and received 3 cycles of docetaxel plus S1. However, he complained with headache and imaging examinations revealed leptomeningeal carcinomatosis...
February 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29462911/anti-inflammatory-and-gastroprotective-roles-of-rabdosia-inflexa-through-downregulation-of-pro-inflammatory-cytokines-and-mapk-nf-%C3%AE%C2%BAb-signaling-pathways
#17
Md Rashedunnabi Akanda, In-Shik Kim, Dongchoon Ahn, Hyun-Jin Tae, Hyeon-Hwa Nam, Byung-Kil Choo, Kyunghwa Kim, Byung-Yong Park
Globally, gastric ulcer is a vital health hazard for a human. Rabdosia inflexa (RI) has been used in traditional medicine for inflammatory diseases. The present study aimed to investigate the protective effect and related molecular mechanism of RI using lipopolysaccharide (LPS)-induced inflammation in RAW 246.7 cells and HCl/EtOH-induced gastric ulcer in mice. We applied 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), nitric oxide (NO), reactive oxygen species (ROS), histopathology, malondialdehyde (MDA), quantitative real-time polymerase chain reaction (qPCR), immunohistochemistry (IHC), and Western blot analyses to evaluate the protective role of RI...
February 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29462183/galanin-is-an-epigenetically-silenced-tumor-suppressor-gene-in-gastric-cancer-cells
#18
Daseul Yoon, Kieun Bae, Min-Kyeong Lee, Jin Hee Kim, Kyong-Ah Yoon
Galanin is a 30 amino-acid active neuropeptide that acts via three G-protein coupled galanin receptors, GALR1, GALR2 and GALR3. Recently, GALR1 was also suggested as a tumor suppressor gene that was frequently silenced in head and neck squamous cell carcinoma; moreover, galanin and GALR1 were reported to inhibit human oral cancer cell proliferation. However, the exact role of galanin in gastric cancer is unclear. Here, we describe the epigenetic silencing of galanin in human gastric cancer. Five gastric cancer cell lines (SNU-1, SNU-601, SNU-638, KATOIII, and AGS) showed a significant reduction in galanin expression that was restored by the demethylating agent 5-aza-2'-deoxycytidine...
2018: PloS One
https://www.readbyqxmd.com/read/29459811/-histological-complete-response-to-neoadjuvant-therapy-in-advanced-gastric-carcinoma-a-case-report-and-review-of-literature
#19
Edgar Fermín Yan Quiroz, Jorge De La Cruz Mio, Víctor Álvarez Díaz, Folker Agreda Castro, Mery Nancy Villarreal González
This communication describes the first case in the Regional Institute of Neoplastic Diseases "Luis Pinillos Ganoza" IREN North in which a patient with advanced gastric carcinoma showed complete response to neoadjuvant histopathologic. We describe the case of a patient woman of 70 years old with histopathologic diagnosis of moderately differentiated tubular gastric adenocarcinoma, locally advanced associated with images of perigastric lymphadenopathy and loss of the interface between gastric tumor, hepatic hilum and gallbladder...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29459563/-a-case-of-8-cm-metastatic-lymph-node-rupture-from-early-gastric-cancer-with-low-papillary-structure
#20
Takao Omori, Takashi Hamada, Ken Ichikawa, Tomoki Kusafuka, Yasuo Ohkura, Youichirou Baba, Hiroki Taoka
A 79-year-old man experiencing sudden abdominal pain was admitted to our hospital. Upper gastrointestinal endoscopy and computed tomography images revealed an 8-cm lesion, suggestive of submucosal tumor in the gastric antrum and a type 0-IIc early gastric cancer in the gastric body. The tumor ruptured during preoperative examinations, which necessitated emergency D1+ distal gastrectomy. Pathological findings confirmed the penetration of the gastric cancer into the submucosa. The cancer comprised well-differentiated tubular carcinoma cells with a low papillary structure...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
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