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https://www.readbyqxmd.com/read/30343531/efficacy-and-safety-of-ixekizumab-in-the-treatment-of-radiographic-axial-spondyloarthritis-16-week-results-of-a-phase-3-randomized-double-blind-placebo-controlled-trial-in-patients-with-prior-inadequate-response-or-intolerance-to-tumor-necrosis-factor-inhibitors
#1
Atul Deodhar, Denis Poddubnyy, Cesar Pacheco-Tena, Carlo Salvarani, Eric Lespessailles, Proton Rahman, Pentti Järvinen, Juan Sanchez-Burson, Karl Gaffney, Eun Bong Lee, Eswar Krishnan, Silvia Santisteban, Xiaoqi Li, Fangyi Zhao, Hilde Carlier, John D Reveille
OBJECTIVE: To investigate the efficacy and safety of ixekizumab in patients with active radiographic axial spondyloarthritis (r-axSpA) and prior inadequate response or intolerance to 1 or 2 TNF inhibitors (TNFi). METHODS: In this randomized, double-blind placebo-controlled, Phase 3 trial, adult patients with inadequate response/intolerance to 1 or 2 TNFi and an established diagnosis of axSpA and fulfilling ASAS criteria for r-axSpA with radiographic sacroiliitis defined per modified NY criteria and ≥1 SpA feature were recruited and randomized 1:1:1 to placebo or 80-mg subcutaneous ixekizumab every 2 (IXEQ2W) or 4 (IXEQ4W) weeks, with a 80-mg or 160-mg starting dose...
October 20, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/30343489/automated-symptom-and-treatment-side-effect-monitoring-for-improved-quality-of-life-among-adults-with-diabetic-peripheral-neuropathy-in-primary-care-a-pragmatic-cluster-randomized-controlled-trial
#2
A S Adams, J A Schmittdiel, A Altschuler, E A Bayliss, R Neugebauer, L Ma, W Dyer, J Clark, B Cook, D Willyoung, M Jaffe, J D Young, E Kim, J M Boggs, L Prosser, E Wittenberg, B Callaghan, M Shainline, R M Hippler, R W Grant
AIMS: To evaluate the effectiveness of automated symptom and side effect monitoring on quality of life among individuals with symptomatic diabetic peripheral neuropathy. METHODS: We conducted a pragmatic, cluster randomized controlled trial (July 2014 to July 2016) within a large healthcare system. We randomized 1834 primary care physicians and prospectively recruited from their lists 1270 individuals with neuropathy who were newly prescribed medications for their symptoms...
October 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30343458/cognitive-deficits-in-psychotic-disorders-a-lifespan-perspective
#3
REVIEW
Julia M Sheffield, Nicole R Karcher, Deanna M Barch
Individuals with disorders that include psychotic symptoms (i.e. psychotic disorders) experience broad cognitive impairments in the chronic state, indicating a dimension of abnormality associated with the experience of psychosis. These impairments negatively impact functional outcome, contributing to the disabling nature of schizophrenia, bipolar disorder, and psychotic depression. The robust and reliable nature of cognitive deficits has led researchers to explore the timing and profile of impairments, as this may elucidate different neurodevelopmental patterns in individuals who experience psychosis...
October 20, 2018: Neuropsychology Review
https://www.readbyqxmd.com/read/30343451/black-pepper-and-its-bioactive-constituent-piperine-promising-therapeutic-strategies-for-oral-lichen-planus
#4
REVIEW
Jing-Ya Yang, Jing Zhang, Gang Zhou
Oral lichen planus (OLP) is a common T cell-mediated chronic inflammatory disease with malignant potential and unclear etiology. The present study suggests that antigen-specific mechanisms in which dentritic cells, T lymphocytes and NF-κB signaling pathway play critical roles, are involved in the pathogenesis of OLP. Additionally, it has been indicated that altered expression of cyclooxygenase 2 (COX-2) and imbalanced oxidant-antioxidant status as well as psychological issue may act as promoters to the development of OLP...
October 20, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/30343350/clinical-and-genetic-risk-factors-associated-with-psoriatic-arthritis-among-patients-with-psoriasis
#5
Di Yan, Richard Ahn, Stephen Leslie, Wilson Liao
INTRODUCTION: Psoriatic arthritis (PsA) is a chronic, inflammatory arthritis that affects an estimated 30% of patients with psoriasis. PsA is underdiagnosed in primary care and dermatology clinics due to a variety of reasons, including failure of healthcare providers to ask about symptoms, overlap of symptoms and signs with other rheumatologic conditions, and lack of a specific diagnostic test. A delay in PsA diagnosis and treatment, even as short as 6 months, can lead to decreased quality of life, increased joint damage, and worse long-term physical function...
October 20, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/30343250/using-fmri-and-machine-learning-to-predict-symptom-improvement-following-cognitive-behavioural-therapy-for-psychosis
#6
Eva Tolmeijer, Veena Kumari, Emmanuelle Peters, Steven C R Williams, Liam Mason
Cognitive behavioural therapy for psychosis (CBTp) involves helping patients to understand and reframe threatening appraisals of their psychotic experiences to reduce distress and increase functioning. Whilst CBTp is effective for many, it is not effective for all patients and the factors predicting a good outcome remain poorly understood. Machine learning is a powerful approach that allows new predictors to be identified in a data-driven way, which can inform understanding of the mechanisms underlying therapeutic interventions, and ultimately make predictions about symptom improvement at the individual patient level...
October 10, 2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/30343238/on-the-edge-the-association-between-extreme-values-of-proportional-felt-age-and-functioning
#7
Yuval Palgi, Liat Ayalon, Sharon Avidor, Dikla Segel-Karpas, Ehud Bodner
The present study examined whether endorsing a felt-age that is extremely divergent from one's actual age (whether older or younger) is related to worse functioning four years later. Data were drawn from 4938 participants, who completed the 2008 and 2012 questionnaires of the Health-and-Retirement-Study (HRS). Participants were divided into four groups according to their reported proportional-felt-age: the normative-young (N = 2229), reported a normative felt-age at the median or younger; normative-old (N = 2226), reported normative felt-age at the median and older; and the extremely young and extremely old proportional-felt-age (upper and lower 5% of felt-age; N's = 242 and 241, respectively)...
October 12, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/30343134/amygdala-activation-and-connectivity-to-emotional-processing-distinguishes-asymptomatic-patients-with-bipolar-disorders-and-unipolar-depression
#8
Mayuresh S Korgaonkar, May Erlinger, Isabella A Breukelaar, Philip Boyce, Philip Hazell, Cassandra Antees, Sheryl Foster, Stuart M Grieve, Lavier Gomes, Leanne M Williams, Anthony W F Harris, Gin S Malhi
BACKGROUND: Mechanistically based neural markers, such as amygdala reactivity, offer one approach to addressing the challenges of differentiating bipolar and unipolar depressive disorders independently from mood state and acute symptoms. Although emotion-elicited amygdala reactivity has been found to distinguish patients with bipolar depression from patients with unipolar depression, it remains unknown whether this distinction is traitlike and present in the absence of an acutely depressed mood...
August 31, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/30343133/abnormal-prefrontal-development-in-pediatric-posttraumatic-stress-disorder-a-longitudinal-structural-and-functional-magnetic-resonance-imaging-study
#9
Sara A Heyn, Taylor J Keding, Marisa C Ross, Josh M Cisler, Jeanette A Mumford, Ryan J Herringa
BACKGROUND: Prior studies of pediatric posttraumatic stress disorder (PTSD) have reported cross-sectional and age-related structural and functional brain abnormalities in networks associated with cognitive, affective, and self-referential processing. However, no reported studies have comprehensively examined longitudinal gray matter development and its intrinsic functional correlates in pediatric PTSD. METHODS: Twenty-seven youths with PTSD and 21 nontraumatized typically developing (TD) youths were assessed at baseline and 1-year follow-up...
August 16, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/30343131/differential-roles-of-the-salience-network-during-prediction-error-encoding-and-facial-emotion-processing-among-female-adolescent-assault-victims
#10
Josh M Cisler, Karyn Esbensen, Kyrie Sellnow, Marisa Ross, Shelby Weaver, Anneliis Sartin-Tarm, Ryan J Herringa, Clinton D Kilts
BACKGROUND: Early-life assaultive violence exposure is a potent risk factor for posttraumatic stress disorder (PTSD) and other mood and anxiety disorders. Neurocircuitry models posit that increased risk is mediated by heightened emotion processing in a salience network including the dorsal anterior cingulate cortex, anterior insula, and amygdala. However, the processes of reinforcement learning (RL) also engage the salience network and are implicated in responses to early-life trauma and PTSD...
September 11, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/30342783/improved-endogenous-epoxyeicosatrienoic-acid-production-mends-heart-function-via-increased-pgc-1%C3%AE-mitochondrial-functions-in-metabolic-syndrome
#11
Lu Liu, Xin Huang, Jinliao Gao, Yusong Guo, Yanqi Di, Shasha Sun, Xinli Deng, Jian Cao
Metabolic syndrome (MS) is a combination of symptoms characterized by central obesity, hypertension, hyperglycemia, and hyperlipidemia, which together increase the risk of heart disease, stroke and diabetes. In our study, we hypothesized that an EET-agonist (AUDA) would increase expression of PGC 1α and improve mitochondrial and endothelial functions, resulting in improved heart function in a rat model of MS. To investigate this, rats were randomly divided into four groups: 1) Control; 2) MS + ABCT; 3) MS + AUDA; and 4) MS + AUDA + SnMP...
October 4, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/30342719/clinical-efficacy-of-serum-derived-bovine-immunoglobulin-in-patients-with-refractory-inflammatory-bowel-disease
#12
Hammad Liaquat, Munish Ashat, Abigail Stocker, Lindsay McElmurray, Karen Beatty, Thomas L Abell, Gerald Dryden
BACKGROUND: Inflammatory bowel disease (IBD) can have autoimmunity and/or intestinal barrier dysfunction as part of pathophysiology and may be refractory to all available treatment options. Serum-derived bovine immunoglobulin (SBI) binds microbial components with postulated downstream effects of normalized gut immune and barrier function, which may be useful for managing IBD. The purpose of our study was to evaluate the effectiveness of SBI in the management of refractory IBD, particularly symptoms of chronic diarrhea and loose stools...
September 5, 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30342653/approach-to-scorpion-stings-in-pregnancy-a-retrospective-case-series-and-literature-review
#13
Sinan Ates, Mahmut Alp Karahan, Nuray Altay, Kazim Akelci, Nagehan Ikiz, Bulent Guzel, Mandeley Wilhelmina Ozer, Haci Durmus Yilmaz
OBJECTIVE: Scorpion stings remain a serious health problem in many parts of the world. There is very limited information regarding the effects of therapies delivered for scorpion stings in pregnant women on the mother and fetus. They can cause acute conditions such as fetal loss, preterm delivery, or placental abnormalities and can also result in other conditions that may have an effect on the baby in the long term. MATERIALS AND METHODS: In this study the medical records of 24 pregnant women who were admitted to the emergency room at Suruç State Hospital due to scorpion stings between January 1, 2013 and January 1, 2014 were retrospectively reviewed...
October 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/30342484/octo-and-nonagenarians-outlook-on-life-and-death-when-living-with-an-implantable-cardioverter-defibrillator-a-cross-sectional-study
#14
Ingela Thylén, Debra K Moser, Anna Strömberg
BACKGROUND: Elderly individuals are increasingly represented among patients with implantable cardioverter defibrillators (ICD), but data describing life with an ICD are scarse among octo- and nonagenarians. Moreover, few studies have reported those elderly patients' perspective on timly discussions concerning what shock deactivation involves, preferences on battery replacement, and their attitudes about turning off the ICD nearing end-of-life. Consequently, the aim of the study was to describe outlooks on life and death in octo- and nonagenarian ICD-recipients...
October 20, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/30342433/does-fatigue-and-distress-in-a-clinical-cohort-of-adolescents-with-cfs-correlate-with-fatigue-and-distress-in-their-parents
#15
M E Loades, K A Rimes, S Ali, K Lievesley, T Chalder
OBJECTIVES: Previous studies have found that parents of children with CFS are more fatigued, and mothers are more distressed than healthy controls. Managing the disabling symptoms of CFS can result in disruption and burden for the family. Most research has focused on mothers. This study sought to further explore the associations between adolescent fatigue and distress, and parental fatigue and distress, as well as family functioning, including both mothers and fathers. DESIGN: Cross-sectional study of a clinical cohort of consecutive attenders at a specialist chronic fatigue unit...
October 20, 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/30342256/design-of-a-randomized-controlled-trial-to-decrease-depression-and-improve-insulin-sensitivity-in-adolescents-mood-and-insulin-sensitivity-to-prevent-diabetes-mind
#16
Lauren B Shomaker, Lauren Gulley, Allison M Hilkin, Emma Clark, Shelly Annameier, Sangeeta Rao, Bonny Rockette-Wagner, Andrea Kriska, Kenneth P Wright, Eric Stice, Kristen J Nadeau, Megan M Kelsey
BACKGROUND: Depressive symptoms often manifest in adolescence and predict worsening insulin sensitivity, a key precursor in the path to β-cell failure and type 2 diabetes (T2D). OBJECTIVE: To assess the efficacy of a six-week cognitive-behavioral group versus six-week health education group for improving insulin sensitivity and preserving β-cell function in adolescent girls at-risk for T2D with depressive symptoms and evaluate mechanisms underlying the association between depression and insulin dynamics...
October 17, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/30342206/identifying-complications-and-optimizing-consultations-following-trans-radial-arterial-access-for-cardiac-procedures
#17
Ryan Cauley, Winona W Wu, Andres Doval, Elliot Chaikof, Kalon K L Ho, Matthew L Iorio
BACKGROUND: The radial approach to cardiac procedures has become increasingly common. While previous studies have suggested a favorable risk profile, serious complications can occur. The purpose of this study was to examine the incidence, subsequent treatment and outcome of all suspected significant neurovascular complications following trans-radial cardiac procedures at a large US hospital. METHODS: We reviewed all patients who underwent a left heart catheterization, coronary angiogram, or percutaneous coronary intervention via the trans-radial approach at a single large academic medical center in the United States between 2010 and 2016...
October 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30342193/airway-smooth-muscle-relaxant-activity-of-cordia-dodecandra-a-dc-mainly-by-camp-increase-and-calcium-channel-blockade
#18
Amanda Sánchez-Recillas, Laura Rivero-Medina, Rolffy Ortiz-Andrade, Jesus Alfredo Araujo-León, J Salvador Flores-Guido
ETHNOPHARMACOLOGICAL RELEVANCE: The fight against chronic respiratory diseases needs the exploration of new active compounds with properties that contribute to diminish the symptoms or resolve the disease alongside current therapy. MATERIALS AND METHODS: Eight extracts obtained from the bark and leaves of a Mayan medicinal plant used to treat asthma, Cordia dodecandra A. DC., were investigated for their relaxant effect on rat isolated tracheal rings pre-contracted with carbachol [1µM]...
October 17, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30341849/stars-in-abdomen
#19
Ramesh Kumar, Divendu Bhushan, Mukesh Kumar
A 24-year-old male who presented to our emergency department with the history of having ingested mercury due to accidental breakage of the tip of mercury thermometer. He had 3 bouts of vomiting following ingestion; however, mercury beads were not seen in the vomitus. On admission, the patient was clinically stable, and his physical and systemic examinations were unremarkable. His routine investigations which included complete blood count, liver function test, kidney function tests, coagulation profiles, blood glucose, and electrocardiogram were normal...
January 2018: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/30341693/internalized-stigma-anticipated-discrimination-and-perceived-public-stigma-in-adults-with-adhd
#20
Theresa Vera Masuch, Myriam Bea, Barbara Alm, Peter Deibler, Esther Sobanski
The objective of this study is to assess internalized stigma, perceived public stigma, anticipated discrimination and their associations with demographic, psychiatric and psychosocial characteristics in adult ADHD. Stigmatization was assessed with the Internalized Stigma of Mental Illness Scale, the Questionnaire on Anticipated Discrimination and the Questionnaire on Public Stereotypes Perceived by Adults with ADHD. The sample comprised n = 104 adults with ADHD, of whom n = 24 (23.3%) reported high internalized stigma, n = 92 (88...
October 19, 2018: Attention Deficit and Hyperactivity Disorders
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