Yujia Shen, Yiwei Gong, Xiaoli Da, Shajing Gao, Shuo Zhang, Minjuan Sun, Yuanzhi Yang, Xiaoyun Qiu, Menghan Li, Yang Zheng, Fan Fei, Yi Wang, Zhong Chen, Cenglin Xu
Secondary epileptogenesis is characterized by increased epileptic susceptibility and a tendency to generate epileptiform activities outside the primary focus. It is one of the major resultants of pharmacoresistance and failure of surgical outcomes in epilepsy, but still lacks effective treatments. Here, we aimed to test the effects of low-frequency stimulation (LFS) at the subiculum for secondary epileptogenesis in a mouse model. Here, secondary epileptogenesis was simulated at regions both contralateral and ipsilateral to the primary focus by applying successive kindling stimuli...
January 20, 2024: Neuroscience Bulletin