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Homocysteine Severe Sepsis

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https://www.readbyqxmd.com/read/27591199/methionine-metabolites-in-patients-with-sepsis
#1
Orren Wexler, Michael S Gough, Mary Anne M Morgan, Cynthia M Mack, Michael J Apostolakos, Kathleen P Doolin, Robert A Mooney, Erland Arning, Teodoro Bottiglieri, Anthony P Pietropaoli
OBJECTIVE: Sepsis is characterized by microvascular dysfunction and thrombophilia. Several methionine metabolites may be relevant to this sepsis pathophysiology. S-adenosylmethionine (SAM) serves as the methyl donor for trans-methylation reactions. S-adenosylhomocysteine (SAH) is the by-product of these reactions and serves as the precursor to homocysteine. Relationships between plasma total homocysteine concentrations (tHcy) and vascular disease and thrombosis are firmly established...
January 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/26508567/polymorphisms-of-cystathionine-beta-synthase-gene-are-associated-with-susceptibility-to-sepsis
#2
Christoph Sponholz, Marcel Kramer, Franziska Schöneweck, Uwe Menzel, Kolsoum Inanloo Rahatloo, Evangelos J Giamarellos-Bourboulis, Vassileios Papavassileiou, Korina Lymberopoulou, Maria Pavlaki, Ioannis Koutelidakis, Ioannis Perdios, André Scherag, Michael Bauer, Matthias Platzer, Klaus Huse
Sepsis is the systemic inflammatory host response to infection. Cystathionine beta-synthase (CBS)-dependent homocysteine (Hcy) pathway was demonstrated to affect disease severity and mortality in patients with severe sepsis/septic shock. Independent studies identified a single-nucleotide polymorphism (SNP, rs6586282, hg19 chr21:g.44478497C>T) in intron 14 of the CBS-coding gene (CBS) associated with Hcy plasma levels. We aimed to describe the association of this SNP and variants of a splice donor-affecting variable-number tandem repeat (VNTR, NG_008938...
July 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/25302507/homocysteine-plasma-levels-as-a-marker-of-clinical-severity-in-septic-patients
#3
Antonio Coelho Neto, Rodrigo Palácio Azevedo, Maria Bethania Peruzzo Santos, Luciano de Camargo Galdieri, Vânia D'Almeida, Jose Luiz Gomes do Amaral, Flávio Geraldo Resende Freitas, Flavia Ribeiro Machado
OBJECTIVE: Homocysteine and sepsis are both associated with inflammation and endothelial activation. Therefore this study was aimed to evaluate if the plasma homocystein level is related with the septic patient clinical severity. METHODS: Severe sepsis or septic shock patients, with less than 48 hours from organ dysfunction start, were admitted to this prospective observational study. Homocysteine levels were determined by the time of study admission and then on the Days 3, 7 and 14...
December 2010: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/24283416/homocysteine-in-dogs-with-systemic-inflammatory-response-syndrome
#4
B E Patterson, J W Barr, G T Fosgate, N Berghoff, J M Steiner, J S Suchodolski, D M Black
OBJECTIVES: To compare serum concentrations of homocysteine in healthy dogs and those fitting the criteria for systemic inflammatory response syndrome and to compare these values to commonly measured B-vitamins. METHODS: Study dogs were classified into non-infectious systemic inflammatory response syndrome or sepsis groups and blood was drawn on Day 1 of the patient's hospitalisation for measurement of serum homocysteine, folate and cobalamin concentrations. Homocysteine concentration was measured in 51 clinically healthy dogs to serve as the control group...
December 2013: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/24278674/role-of-hydrogen-sulfide-in-the-pathology-of-inflammation
#5
Madhav Bhatia
Hydrogen sulfide (H2S) is a well-known toxic gas that is synthesized in the human body from the amino acids cystathionine, homocysteine, and cysteine by the action of at least two distinct enzymes: cystathionine-γ-lyase and cystathionine-β-synthase. In the past few years, H2S has emerged as a novel and increasingly important biological mediator. Imbalances in H2S have also been shown to be associated with various disease conditions. However, defining the precise pathophysiology of H2S is proving to be a complex challenge...
2012: Scientifica
https://www.readbyqxmd.com/read/22868807/association-between-ischemia-modified-albumin-homocysteine-vitamin-b-12-and-folic-acid-in-patients-with-severe-sepsis
#6
Said Sami Erdem, Fatma Hümeyra Yerlikaya, Hümeyra Çiçekler, Mehmet Gül
BACKGROUND: The aim of the present study was to investigate serum ischemia-modified albumin (IMA), homocysteine, malondialdehyde (MDA), vitamin B(12) and folic acid levels in patients with severe sepsis, compared to healthy control subjects. Also, we examined associations of these parameters with high-sensitivity C-reactive protein (hsCRP) in patients with severe sepsis and healthy control subjects. METHODS: This study was performed on 71 (40 male, 31 female) patients with severe sepsis aged 18-65 years and 70 (34 male, 36 female) healthy control subjects aged 18-65 years...
August 2012: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/20935614/the-effect-of-homocysteine-on-the-clinical-outcomes-of-ventilated-patients-with-severe-sepsis
#7
A Tsantes, I Tsangaris, G Nikolopoulos, P Bagos, P Kopterides, G Antonakos, I Dimopoulou, G Vrioni, V Kapsimali, K Dima, A Armaganidis, A Travlou
BACKGROUND: There is considerable evidence that elevated plasma homocysteine levels are associated with a prothrombotic milieu, whereas activation of the coagulation cascade is an important component of the pathogenesis of sepsis. The protein C pathway has been reported to play a central role both in the propagation of sepsis and a hyperhomocysteinemia-induced hypercoagulable state. Our primary aim was to measure plasma homocysteine levels in mechanically ventilated patients with severe sepsis/septic shock and to assess the association of these levels with relevant clinical outcomes...
October 2010: Minerva Anestesiologica
https://www.readbyqxmd.com/read/20592675/the-effect-of-homocysteine-on-the-clinical-outcomes-of-ventilated-patients-with-severe-sepsis
#8
A Tsantes, I Tsangaris, G Nikolopoulos, P Bagos, P Kopterides, G Antonakos, I Dimopoulou, G Vrioni, V Kapsimali, K Dima, A Armaganidis, A Travlou
AIM: There is considerable evidence that elevated plasma homocysteine levels are associated with a prothrombotic milieu, whereas activation of the coagulation cascade is an important component of the pathogenesis of sepsis. The protein C pathway has been reported to play a central role both in the propagation of sepsis and a hyperhomocysteinemia-induced hypercoagulable state. Our primary aim was to measure plasma homocysteine levels in mechanically ventilated patients with severe sepsis/septic shock and assess the association of these levels with relevant clinical outcomes...
July 1, 2010: Minerva Anestesiologica
https://www.readbyqxmd.com/read/17667218/enoxaparin-induced-skin-necrosis-a-fatal-outcome
#9
Sarabjeet Singh, Meenakshi Verma, Amol Bahekar, Preeti Agrawal, Jasleen Duggal, Maria Iliescu, Pam Khosla, Shirin Muzaffar
Enoxaparin, a low-molecular-weight heparin used to treat and prevent deep venous thrombosis, has been evaluated in several clinical trials. Thrombosis induced by enoxaparin with no evidence of heparin-induced thrombocytopenia (HIT) is seldom described. We report a rare case in which an 89-year-old African-American female developed large, multiple, painful lesions induced by enoxaparin administration. Laboratory investigations for HIT, disseminated intravascular coagulation, protein C, protein S, factor V, factor VIII, antithrombin III, and homocysteine deficiency were negative...
July 2007: American Journal of Therapeutics
https://www.readbyqxmd.com/read/17068736/-polymyxin-b-direct-hemoperfusion-pmx-dhp-in-gram-negative-sepsis
#10
A F Perego, S Morabito, G Graziani, G P Casella, O Parodi
UNLABELLED: Severe sepsis and septic shock have a mortality rate that may range between 28 and 50%. It is estimated that approximately 200,000 patients die per annum in the USA as a consequence of sepsis. The reduction of plasma endotoxin levels to achieve a favourable outcome for septic patients has been previously demonstrated but the effectiveness of treatments targeting single inflammatory mediators during established sepsis has been disappointing. Furthermore,some clinical study clinically showed valuable reduction in cytokine levels by hemofiltration alone...
May 2006: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/16702341/adequate-range-for-sulfur-containing-amino-acids-and-biomarkers-for-their-excess-lessons-from-enteral-and-parenteral-nutrition
#11
REVIEW
Marcel C G van de Poll, Cornelis H C Dejong, Peter B Soeters
The adequacy range of dietary requirements of specific amino acids in disease states is difficult to determine. In health, several techniques are available allowing rather precise quantification of requirements based on growth of the organism, rises in plasma concentration, or increases in the oxidation of marker amino acids during incremental administration of the amino acid under study. Requirements may not be similar in disease with regard to protein synthesis or with regard to specific functions such as scavenging of reactive oxygen species by compounds including glutathione...
June 2006: Journal of Nutrition
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