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JOURNAL ARTICLE
Emma Vlasiuk, Patrice Rosengrave, Ella Roberts, Joseph M Boden, Geoff Shaw, Anitra C Carr
Patients with septic shock are under an intense inflammatory burden, which is closely associated with increased oxidative stress and depletion of antioxidants such as vitamin C. We hypothesized that patients with septic shock would present with elevated oxidative stress (assessed as F2 -isoprostanes) and that administration of parenteral vitamin C to these patients would attenuate F2 -isoprostane concentrations. We recruited 40 critically ill patients with septic shock into a randomized placebo-controlled trial and assessed the effect of short-term (4-day) parenteral vitamin C administration (100 mg/kg/d) on 8-isoprostane F2α concentrations, which were measured using enzyme-linked immunosorbent assays...
October 23, 2022: Nutrition Research
#22
JOURNAL ARTICLE
Nur Canbolat, Bahattin Ozkul, Ibrahim Halil Sever, Ibrahim Sogut, Ebru Eroglu, Yigit Uyanikgil, Oytun Erbas
BACKGROUND: Sepsis is one of the leading causes of death in intensive care units worldwide. Vitamins C and E are natural antioxidants and anti-inflammatory agents. Suppressing the inflammation is an important treatment target because it plays a role in the pathophysiology of sepsis. The purpose of this study was to investigate the effect of vitamins C and E treatment in rats with sepsis-induced lung damage. METHODS: In this animal study, fecal intraperitoneal injection procedure (FIP) was performed on 30 of 40 rats included for creating a sepsis model...
2022: Bratislavské Lekárske Listy
#23
REVIEW
Deven Juneja, Anish Gupta, Sahil Kataria, Omender Singh
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as one of the most dreadful viruses the mankind has witnessed. It has caused world-wide havoc and wrecked human life. In our quest to find therapeutic options to counter this threat, several drugs have been tried, with varying success. Certain agents like corticosteroids, some anti-virals and immunosuppressive drugs have been found useful in improving clinical outcomes. Vitamin C, a water-soluble vitamin with good safety profile, has been tried to reduce progression and im-prove outcomes of patients with coronavirus disease 2019 (COVID-19)...
September 25, 2022: World Journal of Virology
#24
JOURNAL ARTICLE
Pinar Oner, Besir Er, Cemal Orhan, Kazim Sahin
Sepsis is related to systemic inflammation and oxidative stress, the primary causes of death in intensive care units. Severe functional abnormalities in numerous organs can arise due to sepsis, with acute lung damage being the most common and significant morbidity. Spirulina, blue-green algae with high protein, vitamins, phycocyanin, and antioxidant content, shows anti-inflammatory properties by decreasing the release of cytokines. In addition, zinc (Zn) and selenium (Se) act as an antioxidant by inhibiting the oxidation of macromolecules, as well as the inhibition of the inflammatory response...
September 29, 2022: Biological Trace Element Research
#25
REVIEW
Ellen Dresen, Zheng-Yii Lee, Aileen Hill, Quirin Notz, Jayshil J Patel, Christian Stoppe
In 1747, an important milestone in the history of clinical research was set, as the Scottish surgeon James Lind conducted the first randomized controlled trial. Lind was interested in scurvy, a severe vitamin C deficiency which caused the death of thousands of British seamen. He found that a dietary intervention with oranges and lemons, which are rich in vitamin C by nature, was effective to recover from scurvy. Because of its antioxidative properties and involvement in many biochemical processes, the essential micronutrient vitamin C plays a key role in the human biology...
February 2023: Nutrition in Clinical Practice
#26
JOURNAL ARTICLE
Jong Eun Park, Tae Gun Shin, Daun Jeong, Gun Tak Lee, Seung Mok Ryoo, Won Young Kim, You Hwan Jo, Gil Joon Suh, Sung Yeon Hwang
The prognostic value of low vitamin C levels has not been well investigated in patients with septic shock. We aimed to evaluate the association of vitamin C deficiency with mortality in patients with septic shock. We conducted a retrospective analysis of 165 patients with septic shock from a prospective multicenter trial and institutional sepsis registry between April 2018 and January 2020. The primary outcome was 28-day mortality. The patients were categorized into vitamin C deficiency and normal groups based on a vitamin C cutoff level of 11...
August 26, 2022: Biomedicines
#27
JOURNAL ARTICLE
Wessam A El Driny, Ibrahim M Esmat, Sara M Shaheen, Nagwa A Sabri
Background: Critically ill patients have an increased requirement for vitamin C in sepsis and these patients have low levels of vitamin C. The researchers validated the efficacy of high-dose vitamin C intravenous infusion (IVI) in patients with sepsis requiring mechanical ventilation. Methods: Forty patients were randomly assigned to 2 groups (20 each) in a 1 : 1 ratio in accordance with the vitamin C treatment regimen: Group I (GI): patients received 1.5 g/6 h vitamin C in 50 ml of dextrose 5% in water (D5W) IVI over 30 minutes for 4 consecutive days; Group II (GII): patients received 100 mg vitamin C/day as a first single dose in 50 ml of D5W IVI over 30 minutes and the other three subsequent doses were 50 ml of plain D5W IVI over 30 minutes for 4 consecutive days...
2022: Anesthesiology Research and Practice
#28
REVIEW
Tomoko Fujii, Yugeesh R Lankadeva, Rinaldo Bellomo
PURPOSE OF REVIEW: Several studies have recently explored the effects of intravenous vitamin C in sepsis. We aimed to summarize their findings to provide perspectives for future research. RECENT FINDINGS: Sepsis trials examined 6 g/day of intravenous vitamin C with or without the thiamine and/or hydrocortisone compared with placebo or hydrocortisone. Network meta-analysis reported that intravenous vitamin C, thiamine, hydrocortisone, or combinations of these drugs was not proven to reduce long-term mortality...
August 1, 2022: Current Opinion in Critical Care
#29
RANDOMIZED CONTROLLED TRIAL
François Lamontagne, Marie-Hélène Masse, Julie Menard, Sheila Sprague, Ruxandra Pinto, Daren K Heyland, Deborah J Cook, Marie-Claude Battista, Andrew G Day, Gordon H Guyatt, Salmaan Kanji, Rachael Parke, Shay P McGuinness, Bharath-Kumar Tirupakuzhi Vijayaraghavan, Djillali Annane, Dian Cohen, Yaseen M Arabi, Brigitte Bolduc, Nicole Marinoff, Bram Rochwerg, Tina Millen, Maureen O Meade, Lori Hand, Irene Watpool, Rebecca Porteous, Paul J Young, Frederick D'Aragon, Emilie P Belley-Cote, Elaine Carbonneau, France Clarke, David M Maslove, Miranda Hunt, Michaël Chassé, Martine Lebrasseur, François Lauzier, Sangeeta Mehta, Hector Quiroz-Martinez, Oleksa G Rewa, Emmanuel Charbonney, Andrew J E Seely, Demetrios J Kutsogiannis, Remi LeBlanc, Armand Mekontso-Dessap, Tina S Mele, Alexis F Turgeon, Gordon Wood, Sandeep S Kohli, Jason Shahin, Pawel Twardowski, Neill K J Adhikari
BACKGROUND: Studies that have evaluated the use of intravenous vitamin C in adults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown mixed results with respect to the risk of death and organ dysfunction. METHODS: In this randomized, placebo-controlled trial, we assigned adults who had been in the ICU for no longer than 24 hours, who had proven or suspected infection as the main diagnosis, and who were receiving a vasopressor to receive an infusion of either vitamin C (at a dose of 50 mg per kilogram of body weight) or matched placebo administered every 6 hours for up to 96 hours...
June 23, 2022: New England Journal of Medicine
#30
JOURNAL ARTICLE
Ayed A Shati, Mohamed Samir A Zaki, Youssef A Alqahtani, Saleh M Al-Qahtani, Mohamed A Haidara, Amal F Dawood, Asmaa M AlMohanna, Mahmoud H El-Bidawy, Muhammad Alaa Eldeen, Refaat A Eid
In severe cases of sepsis, endotoxin-induced cardiomyopathy can cause major damage to the heart. This study was designed to see if Vitamin C (Vit C) could prevent lipopolysaccharide-induced heart damage. Eighteen Sprague Dawley male rats ( n = 6) were divided into three groups. Rats received 0.5 mL saline by oral gavage in addition to a standard diet (Control group), rats received one dose of endotoxin on day 15 (lipopolysaccharide) (LPS) (6 mg/kg), which produced endotoxemia (Endotoxin group), and rats that received 500 mg/Kg BW of Vit C by oral gavage for 15 days before LPS administration (Endotoxin plus Vit C group)...
May 23, 2022: Current Issues in Molecular Biology
#31
JOURNAL ARTICLE
Bingbing Cai, Xue Lv, Ming Lin, Changfu Feng, Changneng Chen
BACKGROUND: Vitamin C deficiency is common in sepsis patients and is related to disease severity. At present, sepsis still has a high incidence and fatality rate. In sepsis, the body may develop microcirculation disorders and even develop organ failure. Exogenous vitamin C supplementation may be one of the effective adjuvant treatment measures for sepsis, which can not only improve the microcirculation of the body, but also affect the prognosis of patients by participating in the synthesis of norepinephrine, improving peripheral vascular resistance and increasing perfusion pressure...
April 2022: Annals of Palliative Medicine
#32
REVIEW
Umar Shahbaz, Nazira Fatima, Samra Basharat, Asma Bibi, Xiaobin Yu, Muhammad Iftikhar Hussain, Maryam Nasrullah
Vitamin C stands as an essential water-soluble vitamin, antioxidant and has been shown to enhance immunity. SARS-CoV-2 has been spreading rapidly across the worldwide, several cellular processes of innate and adaptive immunity are aided by vitamin C, which strengthens the immune system overall. Multiple lines of evidence in the literature associate vitamin C with antioxidant, anti-inflammatory, anticoagulant and immunomodulatory actions. Pneumonia and sepsis patients had poor ascorbic acid status and high oxidative stress, according to many studies...
2022: AIMS Microbiology
#33
Adela Chirita-Emandi, Carmen-Angela-Maria Petrescu, Cristian G Zimbru, Florina Stoica, Catalin Marian, Andreea Ciubotaru, Mihaela Bataneant, Maria Puiu
Bone marrow failure represents an umbrella diagnosis for several life-threatening disorders. In many people, the etiology remains unknown for a long time, leading to an odyssey to diagnosis, with numerous tests performed and sometimes inappropriate treatment. Biallelic pathogenic variants in the DNAJC21 gene were recently discovered to cause bone marrow failure syndrome type 3, having phenotypic overlap with Fanconi anemia, dyskeratosis congenita, Shwachman-Diamond syndrome, and Diamond-Blackfan anemia. Herein, we report an 8-year-old boy, with normal intellect, presenting bone marrow failure; growth retardation; failure to thrive; recurrent infections (including sepsis); cryptorchidia; skeletal, skin, teeth, and hair abnormalities; joint hypermobility; eczema; palpebral ptosis; high myopia; rod-cone retinal dystrophy; and short telomeres...
2022: Frontiers in Genetics
#34
JOURNAL ARTICLE
Neill Kj Adhikari, Ruxandra Pinto, Andrew G Day, Marie-Hélène Masse, Julie Ménard, Sheila Sprague, Djillali Annane, Yaseen M Arabi, Marie-Claude Battista, Dian Cohen, Deborah J Cook, Gordon H Guyatt, Daren K Heyland, Salmaan Kanji, Shay P McGuinness, Rachael L Parke, Bharath Kumar Tirupakuzhi Vijayaraghavan, Emmanuel Charbonney, Michaël Chassé, Lorenzo Del Sorbo, Demetrios James Kutsogiannis, François Lauzier, Rémi Leblanc, David M Maslove, Sangeeta Mehta, Armand Mekontso Dessap, Tina S Mele, Bram Rochwerg, Oleksa G Rewa, Jason Shahin, Pawel Twardowski, Paul Jeffrey Young, François Lamontagne
BACKGROUND: The LOVIT (Lessening Organ Dysfunction with Vitamin C) trial is a blinded multicenter randomized clinical trial comparing high-dose intravenous vitamin C to placebo in patients admitted to the intensive care unit with proven or suspected infection as the main diagnosis and receiving a vasopressor. OBJECTIVE: We aim to describe a prespecified statistical analysis plan (SAP) for the LOVIT trial prior to unblinding and locking of the trial database. METHODS: The SAP was designed by the LOVIT principal investigators and statisticians, and approved by the steering committee and coinvestigators...
May 20, 2022: JMIR Research Protocols
#35
JOURNAL ARTICLE
Andrea L Hess, Alexandra Halalau, Jonathan J Dokter, Tania S Paydawy, Patrick Karabon, Aveh Bastani, Rebecca E Baker, Abdalla Kara Balla, Stephen A Galens
Intravenous vitamin C (IV-VitC) has been suggested as a treatment for severe sepsis and acute respiratory distress syndrome; however, there are limited studies evaluating its use in severe COVID-19. Efficacy and safety of high-dose IV-VitC (HDIVC) in patients with severe COVID-19 were evaluated. This observational cohort was conducted at a single-center, 530 bed, community teaching hospital and took place from March 2020 through July 2020. Inverse probability treatment weighting (IPTW) was utilized to compare outcomes in patients with severe COVID-19 treated with and without HDIVC...
September 2022: Internal and Emergency Medicine
#36
REVIEW
Lauren Burgunder, Caroline Heyrend, Jared Olson, Chanelle Stidham, Roni D Lane, Jennifer K Workman, Gitte Y Larsen
Sepsis is a life-threatening response to infection that contributes significantly to neonatal and pediatric morbidity and mortality worldwide. The key tenets of care include early recognition of potential sepsis, rapid intervention with appropriate fluids to restore adequate tissue perfusion, and empiric antibiotics to cover likely pathogens. Vasoactive/inotropic agents are recommended if tissue perfusion and hemodynamics are inadequate following initial fluid resuscitation. Several adjunctive therapies have been suggested with theoretical benefit, though definitive recommendations are not yet supported by research reports...
May 2022: Paediatric Drugs
#37
REVIEW
Rosangela Passos de Jesus, Jozélio Freire de Carvalho, Lucivalda Pereira Magalhães de Oliveira, Carla de Magalhães Cunha, Thaisy Cristina Honorato Santos Alves, Sandra Tavares Brito Vieira, Virginia Maria Figueiredo, Allain Amador Bueno
Obesity, diabetes, cardiovascular and respiratory diseases, cancer and smoking are risk factors for negative outcomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can quickly induce severe respiratory failure in 5% of cases. Coronavirus disease-associated liver injury may occur during progression of SARS-CoV-2 in patients with or without pre-existing liver disease, and damage to the liver parenchyma can be caused by infection of hepatocytes. Cirrhosis patients may be particularly vulnerable to SARS-CoV-2 if suffering with cirrhosis-associated immune dysfunction...
January 27, 2022: World Journal of Hepatology
#38
JOURNAL ARTICLE
Amarah Baluch, David Landsberg
Scurvy, caused by vitamin C deficiency, is a forgotten disease in the modern era of medicine. The prevalence of vitamin C deficiency in the United States is reported to be 7.1%. We present a case of a 56-year-old man with a history of chronic alcohol use who was admitted to the intensive care unit due to sepsis. He was found to have a rash on his hands and feet which consisted of palpable lesions as well as petechiae. Work up of the patient's skin pathology revealed ascorbic acid deficiency, also known as scurvy...
2021: Journal of Investigative Medicine High Impact Case Reports
#39
JOURNAL ARTICLE
Noha A Kamel, Moetaza M Soliman, Maha A Abo-Zeid, Mona I Shaaban
Background: Sepsis development in patients with trauma is associated with bad prognosis. This study investigated the effect of immunomodulatory interventions in major trauma patients at high risk for sepsis. Methods: In a randomized, double-blinded, controlled design, severe trauma patients were stratified by leukocyte anti-sedimentation rate (LAR) test into high risk (HR) and low risk (LR) for sepsis. The HR patients were randomly allocated into intravenous vitamin C plus vitamin B1 (HR-CB), intramuscular vitamin D plus oral Lactobacillus probiotics (HR-DP), or control (HR-C) groups...
2021: Frontiers in Pharmacology
#40
REVIEW
Brittany D Bissell, Jeannee Campbell, Reagan Collins, Charles Cook, Dharati Desai, Jessica DeWitt, Ifeoma Mary Eche, Ijeoma Julie Eche, Pansy Elsamadisi, Janelle Juul, Soyoung Kim, Courtney T Makowski, Ruben J Mylvaganam, Adam Smith, Jennifer Stancati, Katherine Stonesifer, Justin Tawil, Melanie Smith Condeni
OBJECTIVES: To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2020. DATA SOURCES: The Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update group screened 36 journals monthly for impactful publications. STUDY SELECTION: The group reviewed a total of 119 articles during 2020 according to relevance for practice. DATA EXTRACTION: Articles were selected with consensus and importance to clinical practice from those included in the monthly Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update...
December 2021: Critical care explorations
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