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Vitamin C Severe Sepsis

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https://www.readbyqxmd.com/read/30286493/-do-vitamins-play-a-role-in-the-pathogenesis-and-therapy-of-sepsis
#1
Ulrich Häussler, Reimer Riessen, Michael Haap
Hospital mortality of severe sepsis and septic shock is still around 40 % according to recent studies. In accordance to the current sepsis definition, sepsis is a life-threatening organ dysfunction caused by a dysregulated response of the organism to infection. Septic shock is defined by vasopressor-dependent circulatory failure and lactic acidosis. Patients with sepsis and septic shock are often old and/or characterized by severe comorbidities, e. g. tumor or liver disease. These factors also predispose to malnutrition and hence to a corresponding deficiency of essential nutritional components e...
October 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/30098738/emerging-adjunctive-approach-for-the-treatment-of-sepsis-vitamin-c-and-thiamine
#2
REVIEW
Jennifer E Badeaux, Jennifer B Martin
Evidence is emerging that parenteral administration of high-dose vitamin C and thiamine may be a beneficial adjuvant therapy of severe sepsis and septic shock. Despite modern practices in critical care medicine, sepsis and severe sepsis remain a leading cause of morbidity and mortality in the critical care unit.
September 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/30021102/applications-of-vitamin-d-in-sepsis-prevention
#3
REVIEW
Fernanda A C Takeuti, Fernando de S F Guimaraes, Paulo de S F Guimaraes
Vitamin D (VD) is a steroid prohormone that regulates the body's calcium and phosphate levels in bone mineralization. It is also well described as a fat-soluble vitamin playing an important role in immunomodulation, regulation of cytokines, and cell proliferation. Thus, VD is a powerful hormone with pleiotropic effects, which acts to maintain optimal health. Recent studies demonstrate that VD deficiency is associated with the development of cardiovascular diseases, autoimmune disorders, and various types of cancer, each associated with increased mortality rates...
June 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29864039/vitamin-c-should-we-supplement
#4
Angélique M E Spoelstra-de Man, Paul W G Elbers, Heleen M Oudemans-Van Straaten
PURPOSE OF REVIEW: Hypovitaminosis C and vitamin C deficiency are very common in critically ill patients due to increased needs and decreased intake. Because vitamin C has pleiotropic functions, deficiency can aggravate the severity of illness and hamper recovery. RECENT FINDINGS: Vitamin C is a key circulating antioxidant with anti-inflammatory and immune-supporting effects, and a cofactor for important mono and dioxygenase enzymes. An increasing number of preclinical studies in trauma, ischemia/reperfusion, and sepsis models show that vitamin C administered at pharmacological doses attenuates oxidative stress and inflammation, and restores endothelial and organ function...
August 2018: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29590167/serum-vitamin-d-concentrations-in-hospitalized-critically-ill-dogs
#5
Jared A Jaffey, Robert C Backus, Kaylyn M McDaniel, Amy E DeClue
Hypovitaminosis D has been extensively documented in critically ill humans. However, whether or not critically ill dogs have alterations in vitamin D concentrations remains unconfirmed. The primary aims of our study were to compare serum 25-hydroxycholecalciferol [25(OH)D] concentrations in critically ill dogs with healthy control dogs, determine the prognostic utility of serum 25(OH)D concentration as a biomarker in critically ill dogs, and to assess if serum 25(OH)D concentrations in critically ill dogs are associated with length of stay in the intensive care unit or illness severity...
2018: PloS One
https://www.readbyqxmd.com/read/29559543/bet-2-does-intravenous-vitamin-c-improve-mortality-in-patients-with-severe-sepsis
#6
REVIEW
Mohammed Sheikh, Daniel Horner
A shortcut review was carried out to establish whether the use of intravenous vitamin C can reduce mortality or morbidity in patients diagnosed in the early phases of severe sepsis. Three directly relevant papers were found using the reported search strategy. The author, date and country of publication; patient group studied; study type; relevant outcomes; results and study weaknesses of the best papers are tabulated. It is concluded that there is insufficient high-quality research to justify the routine use of vitamin C in severe sepsis...
April 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29310566/analysis-of-oxidative-stress-related-markers-in-critically-ill-polytrauma-patients-an-observational-prospective-single-center-study
#7
Mihai Sandesc, Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Anca Dinu, Marius Papurica, Carmen Alina Cradigati, Mirela Sarandan, Sonia Elena Popovici, Lavinia Melania Bratu, Tiberiu Bratu, Adrian Tudor Stan, Dorel Sandesc
Critically ill polytrauma patients have increased production of free radicals (FRs) and consequent alterations in biochemical pathways, as well as disruption of cellular integrity, due to increased lipid peroxidation. The aim of this study was to investigate several biomarkers associated with increased oxidative stress in critically ill polytrauma patients, and to evaluate the effect of antioxidant treatment on the clinical outcome in these patients. A total of 67 polytrauma patients from an intensive care unit met the selection criteria...
May 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28599924/how-to-give-vitamin-c-a-cautious-but-fair-chance-in-severe-sepsis
#8
EDITORIAL
Heleen M Oudemans-van Straaten, Paul W G Elbers, Angélique M E Spoelstra-de Man
No abstract text is available yet for this article.
June 2017: Chest
https://www.readbyqxmd.com/read/28224112/intravenous-vitamin-c-as-adjunctive-therapy-for-enterovirus-rhinovirus-induced-acute-respiratory-distress-syndrome
#9
Alpha A Fowler Iii, Christin Kim, Lawrence Lepler, Rajiv Malhotra, Orlando Debesa, Ramesh Natarajan, Bernard J Fisher, Aamer Syed, Christine DeWilde, Anna Priday, Vigneshwar Kasirajan
We report a case of virus-induced acute respiratory distress syndrome (ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth University with vitamin C and with the very positive results of a previously performed phase I safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic...
February 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27940189/hydrocortisone-vitamin-c-and-thiamine-for-the-treatment-of-severe-sepsis-and-septic-shock-a-retrospective-before-after-study
#10
Paul E Marik, Vikramjit Khangoora, Racquel Rivera, Michael H Hooper, John Catravas
BACKGROUND: The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries. METHODS: In this retrospective before-after clinical study, we compared the outcome and clinical course of consecutive septic patients treated with intravenous vitamin C, hydrocortisone, and thiamine during a 7-month period (treatment group) with a control group treated in our ICU during the preceding 7 months...
June 2017: Chest
https://www.readbyqxmd.com/read/27632669/vitamin-d-deficiency-in-human-and-murine-sepsis
#11
Dhruv Parekh, Jaimin M Patel, Aaron Scott, Sian Lax, Rachel C A Dancer, Vijay D'Souza, Hannah Greenwood, William D Fraser, Fang Gao, Elizabeth Sapey, Gavin D Perkins, David R Thickett
OBJECTIVES: Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and ICU mortality but causality of these associations has not been demonstrated. To determine whether sepsis and severe sepsis are associated with vitamin D deficiency and to determine whether vitamin D deficiency influences the severity of sepsis. DESIGN, SETTING, AND PATIENTS: Sixty-one patients with sepsis and severe sepsis from two large U.K. hospitals and 20 healthy controls were recruited...
February 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/27182850/-vitamin-s-steroids-and-vitamin-c-for-the-treatment-of-severe-sepsis-and-septic-shock
#12
COMMENT
Paul E Marik
No abstract text is available yet for this article.
June 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/26800186/vitamin-d-deficiency-at-admission-is-not-associated-with-90-day-mortality-in-patients-with-severe-sepsis-or-septic-shock-observational-finnaki-cohort-study
#13
MULTICENTER STUDY
Tero I Ala-Kokko, Shivaprakash J Mutt, Sara Nisula, Juha Koskenkari, Janne Liisanantti, Pasi Ohtonen, Meri Poukkanen, Jouko J Laurila, Ville Pettilä, Karl-Heinz Herzig
Introduction Low levels of vitamin D have been associated with increased mortality in patients that are critically ill. This study explored whether vitamin D levels were associated with 90-day mortality in severe sepsis or septic shock. Methods Plasma vitamin D levels were measured on admission to the intensive care unit (ICU) in a prospective multicentre observational study. Results 610 patients with severe sepsis were included; of these, 178 (29%) had septic shock. Vitamin D deficiency (<50 nmol/L) was present in 333 (55%) patients...
2016: Annals of Medicine
https://www.readbyqxmd.com/read/26721785/clinical-and-microbiological-outcome-in-septic-patients-with-extremely-low-25-hydroxyvitamin-d-levels-at-initiation-of-critical-care
#14
G De Pascale, M S Vallecoccia, A Schiattarella, V Di Gravio, S L Cutuli, G Bello, L Montini, M A Pennisi, T Spanu, C Zuppi, S A Quraishi, M Antonelli
A relationship between vitamin D status and mortality in patients in intensive care units (ICU) has been documented. The present study aims to describe the clinical profile and sepsis-related outcome of critically ill septic patients with extremely low (<7 ng/mL) vitamin D levels at ICU admission. We conducted an observational study in the ICU of a teaching hospital including all patients admitted with severe sepsis/septic shock and undergoing 25-hydroxyvitamin D (25(OH)D) testing within the first 24 hours from admission...
May 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/26612352/ascorbate-dependent-vasopressor-synthesis-a-rationale-for-vitamin-c-administration-in-severe-sepsis-and-septic-shock
#15
Anitra C Carr, Geoffrey M Shaw, Alpha A Fowler, Ramesh Natarajan
Severe systemic inflammatory response to infection results in severe sepsis and septic shock, which are the leading causes of death in critically ill patients. Septic shock is characterised by refractory hypotension and is typically managed by fluid resuscitation and administration of catecholamine vasopressors such as norepinephrine. Vasopressin can also be administered to raise mean arterial pressure or decrease the norepinephrine dose. Endogenous norepinephrine and vasopressin are synthesised by the copper-containing enzymes dopamine β-hydroxylase and peptidylglycine α-amidating monooxygenase, respectively...
November 27, 2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/26436558/skin-necrosis-and-purpura-fulminans-in-children-with-and-without-thrombophilia-a-tertiary-center-s-experience
#16
Yariv Fruchtman, Tzipora Strauss, Marina Rubinstein, Miriam Ben Harush, Shoshana Revel-Vilk, Joseph Kapelushmik, Gideon Paret, Gili Kenet
Purpura fulminans (PF) is a very rare clinicopathologic skin disorder comprising dermal microvascular thrombosis associated with perivascular hemorrhage of multiple origins. It may occur as the presenting symptom of severe congenital deficiency of protein C (PC) or protein S (PS) during the newborn period, or later in life following oral anticoagulant therapy with vitamin K antagonists, or of sepsis that may be associated with disseminated intravascular coagulation. Treatment consists of anticoagulants and PC concentrates during acute episodes...
2015: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/26266908/the-effect-of-vitamin-c-on-plasma-volume-in-the-early-stage-of-sepsis-in-the-rat
#17
Björn P Bark, Per-Olof Grände
BACKGROUND: Previous experimental studies have shown that vitamin C has several beneficial effects in sepsis and burns, such as decreased tissue oedema, improved endothelial barrier function and decreased transcapillary leakage of plasma markers. It has still not been investigated, though, if vitamin C has any impact specifically on plasma volume. The present study aims at testing the hypothesis that vitamin C decreases plasma volume loss in sepsis. METHODS: Anaesthetized male adult Sprague-Dawley rats were used in this prospective randomized study...
December 2014: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/26086941/effect-of-cholecalciferol-supplementation-on-vitamin-d-status-and-cathelicidin-levels-in-sepsis-a-randomized-placebo-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Sadeq A Quraishi, Gennaro De Pascale, Joseph S Needleman, Harumasa Nakazawa, Masao Kaneki, Ednan K Bajwa, Carlos A Camargo, Ishir Bhan
OBJECTIVES: To compare changes in vitamin D status and cathelicidin (LL-37) levels in septic ICU patients treated with placebo versus cholecalciferol. DESIGN: Randomized, placebo-controlled, trial. SETTING: Medical and surgical ICUs of a single teaching hospital in Boston, MA. PATIENTS: Thirty adult ICU patients. INTERVENTIONS: Placebo (n = 10) versus 200,000 IU cholecalciferol (n = 10) versus 400,000 IU cholecalciferol (n = 10), within 24 hours of new-onset severe sepsis or septic shock...
September 2015: Critical Care Medicine
https://www.readbyqxmd.com/read/25903964/vitamin-d-deficiency-contributes-directly-to-the-acute-respiratory-distress-syndrome-ards
#19
Rachel C A Dancer, Dhruv Parekh, Sian Lax, Vijay D'Souza, Shengxing Zheng, Chris R Bassford, Daniel Park, D G Bartis, Rahul Mahida, Alice M Turner, Elizabeth Sapey, Wenbin Wei, Babu Naidu, Paul M Stewart, William D Fraser, Kenneth B Christopher, Mark S Cooper, Fang Gao, David M Sansom, Adrian R Martineau, Gavin D Perkins, David R Thickett
RATIONALE: Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory distress syndrome (ARDS). Causality of these associations has never been demonstrated. OBJECTIVES: To determine if ARDS is associated with vitamin D deficiency in a clinical setting and to determine if vitamin D deficiency in experimental models of ARDS influences its severity. METHODS: Human, murine and in vitro primary alveolar epithelial cell work were included in this study...
July 2015: Thorax
https://www.readbyqxmd.com/read/25741906/an-update-on-the-association-of-vitamin-d-deficiency-with-common-infectious-diseases
#20
REVIEW
Richard R Watkins, Tracy L Lemonovich, Robert A Salata
Vitamin D plays an important role in modulating the immune response to infections. Deficiency of vitamin D is a common condition, affecting both the general population and patients in health care facilities. Over the last decade, an increasing body of evidence has shown an association between vitamin D deficiency and an increased risk for acquiring several infectious diseases, as well as poorer outcomes in vitamin D deficient patients with infections. This review details recent developments in understanding the role of vitamin D in immunity, the antibacterial actions of vitamin D, the association between vitamin D deficiency and common infections (like sepsis, pneumonia, influenza, methicillin-resistant Staphylococcus aureus, human immunodeficiency virus type-1 (HIV), and hepatitis C virus (HCV)), potential therapeutic implications for vitamin D replacement, and future research directions...
May 2015: Canadian Journal of Physiology and Pharmacology
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