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Esophageal tumor

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https://www.readbyqxmd.com/read/29774930/-advertent-problems-about-gastric-stump-cancer-surgery
#1
Han Liang
Due to different disease background of gastric stump cancer(GSC) patients (benign or malignant lesion, reconstruction of digestive tract, etc.), the GSC surgical procedure and the difficulty of lymphadenectomy are also different. The extent of radical lymphadenectomy for gastric stump cancer should extend beyond D2 lymphadenectomy, according to the different backgrounds of initial disease, reconstructions, and tumor location. A lymphadenectomy should include the lymph nodes in anterior (No.17) and posterior (No...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29774390/-oligometastases-in-gastric-and-esophageal-cancer-current-clinical-trials-and-surgical-concepts
#2
REVIEW
S Beckert, A Königsrainer
There is an increasing role of surgery even in metastatic tumor stages. In colorectal cancer patients with limited metastases, complete cytoreduction is able to offer long-term survival in synchronic as well as metachronic situations. In tumors of the upper gastrointestinal tract (UGIT), however, the impact of surgery in metastatic disease remains to be clarified. Even though several retrospective studies suggest prolonged survival, surgery is not recommended by the current German S3 guidelines for tumors of the UGIT...
May 17, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29771417/lncrna-fer1l4-suppressed-cancer-cell-growth-and-invasion-in-esophageal-squamous-cell-carcinoma
#3
W Ma, C-Q Zhang, H-L Li, J Gu, G-Y Miao, H-Y Cai, J-K Wang, L-J Zhang, Y-M Song, Y-H Tian, Y-H Song
OBJECTIVE: To investigate the regulatory effect of long non-coding ribonucleic acid (lncRNA) FER1L4 on biological behaviors of esophageal squamous cell carcinoma (ESCC) cells, such as proliferation and invasion. PATIENTS AND METHODS: The expressions of FER1L4 were detected in 42 pairs of ESCC tissues and corresponding para-carcinoma tissues and 5 kinds of ESCC cell lines via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Polyethyleneimine (PEI) and liposomes were used for FER1L4 expression or interference elimination assays, respectively...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29771416/long-non-coding-rna-duxap8-regulates-proliferation-and-invasion-of-esophageal-squamous-cell-cancer
#4
L-J Xu, X-J Yu, B Wei, H-X Hui, Y Sun, J Dai, X-F Chen
OBJECTIVE: The purpose of this research was to detect the expression of long non-coding RNA DUXAP8 in esophageal cancer, and to explore its underlying mechanism in the development of esophageal squamous cell carcinoma (ESCC). PATIENTS AND METHODS: We collected 78 pairs of esophageal cancer tissues and normal adjacent tissues. The mRNA level of DUXAP8 in these esophageal cancer tissues and corresponding adjacent tissues was detected by quantitative Real-time polymerase chain reaction (qRT-PCR)...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29771050/-fibrous-hemangioma-of-esophagus-portal-a-case-report
#5
Y P Wang, L X Li
A 33 year old male patient has found in the oral cavity tumor with nausea and vomiting after 20 days ago. The patients feel pharyngeal foreign body sensation, occasional sense of suffocation, the oropharyngeal tumor disappeared and foreign body sensation disappeared after swallowing. The patients without angina, no hemoptysis, no hoarseness, no acid reflux symptoms and weight loss phenomenon. The gastroscope showed giant tumor, esophagus smooth surface, visible local gray blue blood vessels, from the entrance of esophagus has been extended to the esophagus from the upper incisors 25 cm...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770138/ny-eso-1-based-immunotherapy-of-cancer-current-perspectives
#6
REVIEW
Remy Thomas, Ghaneya Al-Khadairi, Jessica Roelands, Wouter Hendrickx, Said Dermime, Davide Bedognetti, Julie Decock
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. In this review, we provide background information on NY-ESO-1 expression and function in normal and cancerous tissues. Furthermore, NY-ESO-1-specific immune responses have been observed in various cancer types; however, their utility as biomarkers are not well determined...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29767234/microrna-125a-5p-enhances-the-sensitivity-of-esophageal-squamous-cell-carcinoma-cells-to-cisplatin-by-suppressing-the-activation-of-the-stat3-signaling-pathway
#7
Yan Zhao, Ke Ma, Shujun Yang, Xiaosan Zhang, Feng Wang, Xiaqing Zhang, Hongtao Liu, Qingxia Fan
Increasing evidence has demonstrated that microRNAs (miRNAs or miRs) play a variety of roles in tumor development, progression and chemosensitivity in a wide range of tumors. In this study, we found that miR‑125a‑5p exhibited a low expression in esophageal squamous cell carcinoma (ESCC) tissues and cells, and that its low expression was associated with higher tumor staging and shorter a survival time of patients with ESCC. Moreover, miR‑125a‑5p overexpression contributed to the suppression of cell proliferation, cell cycle arrest, cell apoptosis and a decrease in cell migratory and invasive abilities, whereas the downregulation of miR‑125a‑5p promoted cell proliferation, accelerated cell cycle progression, suppressed apoptosis and enhanced the migratory and invasive abilities of ESCC EC1 and TE1 cells, which may be tightly associated with the epithelial‑mesenchymal transition (EMT) process in ESCC...
May 16, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29766388/molecular-evolution-of-metaplasia-to-adenocarcinoma-in-the-esophagus
#8
REVIEW
William M Grady, Ming Yu
Esophageal adenocarcinoma (EAC) develops from Barrett's esophagus (BE), a condition where the normal squamous epithelia is replaced by specialized intestinal metaplasia in response to chronic gastroesophageal acid reflux. In a minority of individuals, BE can progress to low- and high-grade dysplasia and eventually to intra-mucosal and then invasive carcinoma. BE provides researchers with a unique model to characterize the process by which a carcinoma arises from its precursor lesion. Molecular studies of BE have demonstrated that it is not simply a metaplastic tissue, but rather it harbors frequent alterations that are also present in dysplastic BE and in EAC...
May 15, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29765522/establishment-of-preclinical-chemotherapy-models-for-gastroenteropancreatic-neuroendocrine-carcinoma
#9
Akihiro Ohmoto, Masami Suzuki, Erina Takai, Hirofumi Rokutan, Yuko Fujiwara, Chigusa Morizane, Kazuyoshi Yanagihara, Tatsuhiro Shibata, Shinichi Yachida
Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a rare and devastating malignancy, and preclinical studies are needed to evaluate potential therapeutic regimens. Here, we examined the antitumor effects of cisplatin (CDDP), etoposide (ETP) and irinotecan (CPT-11) and their combinations on GEP-NEC using three small-cell GEP-NEC cell lines (pancreatic NEC, A99; esophageal NEC, TYUC-1; duodenum NEC, TCC-NECT-2). In vitro studies were conducted using cell viability assays. In vivo experiments were conducted in mice inoculated with A99 or TCC-NECT-2 and treated with no agent, CDDP, CDDP+ETP (EP) or CDDP+CPT-11 (IP)...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29765235/fatal-hemoptysis-in-patients-with-advanced-esophageal-cancer-treated-with-apatinib
#10
Wei Wang, Lin Zhang, Yan Xie, Tianchang Zhen, Gongzhang Su, Qi Zang
Targeted therapy is commonly used for treating advanced malignant tumors. Compared with cytotoxic drugs, targeted drugs have the characteristics of good curative results, less adverse effects, and convenient oral administration. Hence, they are especially suitable for patients with cancer who are not able to tolerate chemotherapy. Anti-angiogenic therapy can achieve the objective by inhibiting the formation of new blood vessels in tumors. Apatinib is a novel tyrosine kinase inhibitor targeting the intracellular domain of vascular endothelial growth factor receptor-2...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29765221/surgical-treatment-of-an-esophageal-bronchogenic-cyst-with-massive-upper-digestive-tract-hematoma-without-esophagectomy-a-case-report-and-the-review-of-the-literature
#11
Yuanjun Cheng, Donglai Chen, Li Shi, Wentao Yang, Yonghua Sang, Shanzhou Duan, Yongbing Chen
Esophageal bronchogenic cysts are extremely rare. Here we report a case of massive upper digestive tract hematoma and bronchogenic cyst mimicking aortic dissection that was safely removed without esophagectomy. A 30-year-old man was referred to our hospital for the treatment of a mediastinal cystic tumor located in the submucosa of the distal esophagus. His chief complaints were dysphagia > 1 week and severe persistent upper abdominal pain mimicking aortic dissection with constant vomiting for 1 day after gastroscopy examination...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29763634/novel-long-noncoding-rna-nmr-promotes-tumor-progression-via-nsun2-and-bptf-in-esophageal-squamous-cell-carcinoma
#12
Yuan Li, Jiagen Li, Mei Luo, Chengcheng Zhou, Xuejiao Shi, Wenhui Yang, Zhiliang Lu, Zhaoli Chen, Nan Sun, Jie He
Long noncoding RNAs (lncRNA) have been implicated in cancer but most of them remain largely unstudied. Here, we identified a novel NSUN2 methylated lncRNA (NMR), which was significantly upregulated in esophageal squamous cell carcinoma (ESCC), functioned as a key regulator of ESCC tumor metastasis and drug resistance. Upregulation of NMR correlated with tumor metastasis and indicated poor overall survival in ESCC patients. Functionally, NMR could promote tumor cell migration and invasion, inhibit cisplatin-induced apoptosis and increase drug resistance in ESCC cells...
May 12, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29760351/leptin-aggravates-reflux-esophagitis-by-increasing-tissue-levels-of-macrophage-migration-inhibitory-factor-in-rats
#13
Tsugihiro Murata, Kiyotaka Asanuma, Nobuyuki Ara, Katsunori Iijima, Waku Hatta, Shin Hamada, Naoki Asano, Tomoyuki Koike, Akira Imatani, Atsushi Masamune, Tooru Shimosegawa
Leptin, produced primarily by the adipose tissue, acts as a pro-inflammatory modulator, thereby contributing to the development of obesity-related disease. Although high levels of leptin in the obese are closely related to gastroesophageal reflux disease, the mechanism by which leptin influences esophageal inflammation remains unknown. Macrophage migration inhibitory factor (MIF) is produced by immune cells, such as T lymphocytes and macrophages, and MIF is known to induce the production of tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β) and interleukin 6 (IL-6)...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29759332/sunset-stereotactic-radiation-for-ultracentral-non-small-cell-lung-cancer-a-safety-and-efficacy-trial
#14
Meredith Giuliani, Ashwathy S Mathew, Houda Bahig, Scott V Bratman, Edith Filion, Daniel Glick, Alexander V Louie, Srinivas Raman, Anand Swaminath, Andrew Warner, Vivian Yau, David Palma
BACKGROUND: Lung stereotactic body radiotherapy (SBRT) is considered a standard curative treatment for medically inoperable early stage non-small-cell lung cancer (NSCLC). Patients with ultracentral tumors (signifying tumors whose planning target volume touches or overlaps the central bronchial tree, esophagus, or pulmonary artery) may be at higher risk of serious toxicities such as bronchial stricture and collapse, esophageal strictures, tracheal-esophageal fistula, and hemorrhage. The primary objective of the study is to determine the maximum tolerated dose of radiotherapy for ultracentral NSCLC...
April 18, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29757780/effects-of-intraoperative-opioid-use-on-recurrence-free-and-overall-survival-in-patients-with-esophageal-adenocarcinoma-and-squamous-cell-carcinoma
#15
Kim N Du, Lei Feng, Abigail Newhouse, Jeel Mehta, Javier Lasala, Gabriel E Mena, Wayne L Hofstetter, Juan P Cata
BACKGROUND: Perioperative opioid use is associated with poor survival in patients with esophageal squamous cell carcinoma. The most common histological type of esophageal cancer in western countries is adenocarcinoma. The objective of this study was to evaluate the association between intraoperative opioid consumption and survival in patients with adenocarcinoma and squamous cell carcinoma of the esophagus. METHODS: Records of patients who had undergone esophageal cancer surgery between January 2000 and January 2017 were reviewed...
May 10, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29757528/downregulation-of-hoxa13-sensitizes-human-esophageal-squamous-cell-carcinoma-to-chemotherapy
#16
Qi Shi, Luyan Shen, Bin Dong, Hao Fu, Xiaozheng Kang, Liang Dai, Yongbo Yang, Wanpu Yan, Ke-Neng Chen
BACKGROUND: Chemoresistance often develops in esophageal squamous cell carcinoma (ESCC), leading to poor prognosis. HOX genes play a crucial role in embryonic development and cell differentiation. Studies have recently linked HOX with chemoresistance, thus we explored whether HOXA13 is involved in ESCC chemoresistance. METHODS: One hundred thirty-one ESCC patients who received neoadjuvant chemotherapy were enrolled. HOXA13 expression was examined by immunohistochemistry...
May 14, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29751947/surgical-evaluation-of-lymph-nodes-in-esophageal-adenocarcinoma-standardized-approach-or-personalized-medicine
#17
Thomas C Tsai, Jordan Miller, Brian Whang, P Marco Fisichella
The extent of lymphadenectomy for esophageal adenocarcinoma remains controversial. Outstanding issues include the appropriate technical approach such as transthoracic versus transhiatal, or open versus minimally invasive, both of which have implications on overall lymph node harvest numbers and morbidity. Recent data on the relationship of total number of lymph nodes harvested and oncologic survival have been conflicting, due in part to a likely differential impact of lymphadenectomy on survival based on tumor stage and response to neoadjuvant therapy...
April 19, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29750302/lncrna-tp73%C3%A2-as1-predicts-poor-prognosis-and-promotes-cell-proliferation-in-ovarian-cancer-via-cell-cycle-and-apoptosis-regulation
#18
Xiuyun Li, Xiaoyan Wang, Li Mao, Shuhong Zhao, Haidong Wei
TP73‑AS1, a critical cancer‑associated long noncoding RNA (lncRNA), has been identified in esophageal cancer and glioma. However, its biological role in ovarian cancer (OC) remains to be investigated. The aim of the present study was to investigate the role of TP73‑AS1 in human OC cell lines and clinical tumor samples to determine the function of this molecule. Reverse transcription‑quantitative polymerase chain reaction analysis was carried out to detect that TP73‑AS1 was upregulated in OC tissues and cell lines...
May 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29749531/microrna-125b-inhibits-cell-proliferation-and-induces-cell-apoptosis-in-esophageal-squamous-cell-carcinoma-by-targeting-bmf
#19
Yan-Xin Fan, Xiu-Hua Bian, Pu-Dong Qian, Zhen-Zhang Chen, Jing Wen, Yan-Hong Luo, Peng-Wei Yan, Qian Zhang
MicroRNAs (miRNAs) have been reported to regulate the expression of genes by suppressing translation or facilitating mRNA decay. Their expression regulates a wide variety of cellular processes, including the development and progression of cancer. Esophageal squamous cell carcinoma (ESCC) is a malignant cancer with high morbidity and recurrence in Asia. In the present study, the biological function of miR-125b and its underlying mechanism in ESCC were explored. The results revealed that miR-125b expression was significantly decreased in ESCC tissues and cell lines...
May 2, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29749499/stable-silencing-of-dll4-gene-suppresses-the-growth-and-metastasis-of-esophagus-cancer-cells-by-attenuating-akt-phosphorylation
#20
Xianzhi Guo, Yingchun Duan, Xiaolei Ye, Lina Hu, Tong Xu, Li Tong, Minghua Yu
δ‑Like ligand 4 (DLL4) has recently been reported to be involved in the process of cancer angiogenesis and considered to play a vital role in vascular endothelial growth factor (VEGF) signaling, while the role of DLL4 in cancer metastasis and growth has not been systematically studied. In the present study, the esophagus cancer cell line Eca109 was infected in vitro with a lentiviral vector loaded with dll4‑shRNA to obtain a stable cell line of DLL4 expression which was downregulated through puromycin screening...
May 8, 2018: Oncology Reports
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