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https://www.readbyqxmd.com/read/28221296/long-term-outcomes-of-eye-sparing-surgery-for-adenoid-cystic-carcinoma-of-lacrimal-gland
#1
Jisang Han, Yoon-Duck Kim, Kyung In Woo, Deepak Sobti
PURPOSE: This study's primary purpose is to assess the long-term outcomes of patients who have undergone eye-sparing surgery and adjuvant radiotherapy for adenoid cystic carcinoma of the lacrimal gland. METHODS: In this retrospective analysis, clinical records were reviewed of all patients diagnosed with adenoid cystic carcinoma of the lacrimal gland, at a single institution, between March 1998 and November 2012. Ten patients were identified as having undergone eye-sparing surgery and adjuvant radiotherapy for adenoid cystic carcinoma of the lacrimal gland...
February 17, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28215583/clinicopathologic-characteristics-of-metastatic-esophageal-carcinoma-isolated-to-the-pineal-region-a-case-report-and-review-of-the-literature
#2
REVIEW
Margaret E Flanagan, John R Williams, Samuel N Emerson, Peter A Chiarelli, Richard G Ellenbogen, Patrick J Cimino
Metastasis to the pineal region is a rare event, and esophageal adenocarcinoma metastatic to the pineal region is exceptionally rare, with only two cases reported in the current literature. Here, we characterize a third case of metastatic esophageal adenocarcinoma to the pineal region, and compare clinicopathological characteristics among all three cases. The three patients were men, with ages at neurological presentation ranging from 48 to 65years. Time from initial esophageal adenocarcinoma diagnosis to development of neurologic symptoms ranged from 12 to 23months...
February 16, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28212575/upregulation-of-mucin-glycoprotein-muc1-in-the-progression-to-esophageal-adenocarcinoma-and-therapeutic-potential-with-a-targeted-photoactive-antibody-drug-conjugate
#3
Mohammed Adil Butt, Hayley Pye, Rehan J Haidry, Dahmane Oukrif, Saif-U-Rehman Khan, Ignazio Puccio, Michael Gandy, Halla W Reinert, Ellie Bloom, Mohammed Rashid, Gokhan Yahioglu, Mahendra P Deonarain, Rifat Hamoudi, Manuel Rodriguez-Justo, Marco R Novelli, Laurence B Lovat
BACKGROUND: Mucin glycoprotein 1 (MUC1) is a glycosylated transmembrane protein on epithelial cells. We investigate MUC1 as a therapeutic target in Barrett's epithelium (BE) and esophageal adenocarcinoma (EA) and provide proof of concept for a light based therapy targeting MUC1. RESULTS: MUC1 was present in 21% and 30% of significantly enriched pathways comparing BE and EA to squamous epithelium respectively. MUC1 gene expression was x2.3 and x2.2 higher in BE (p=<0...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28211800/upregulated-mir-483-5p-expression-as-a-prognostic-biomarker-for-esophageal-squamous-cell-carcinoma
#4
Liying Xue, Jinglong Nan, Li Dong, Cuiying Zhang, Hui Li, Rentura Na, Huijie He, Yadi Wang
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is one of the most common cause of cancer-associated mortality. Uncovering novel molecular biomarkers that can predict ESCC development will improve personalized therapy. OBJECTIVE: The goal of the current study was to investigate the expression pattern of miR-483-5p and determine its prognostic value in ESCC. METHODS: We first analyzed miRNA-seq data obtained from the Cancer Genome Atlas (TCGA) cohort to evaluate the prognostic value of miR-483-5p in ESCC...
February 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28211282/signet-ring-cell-carcinoma-of-the-jejunum-an-uncommon-finding-within-the-reach-of-capsule-endoscopy
#5
José Francisco Juanmartiñena, Marta Montes, Ignacio Fernández-Urién
An 80 year-old female presented with ductal breast carcinoma (stage II) three years ago, complained of asthenia and iron-deficiency anemia. No diagnosis was obtained after conventional endoscopy and iron supplements were indicated. Ten months later visible digestive hemorrhage was presented. Upper and lower endoscopy was repeated but non-diagnosis was obtained. Thus, video capsule endoscopy was indicated identifying a stenotic lesion arising in the mucosa of distal jejunum. Histopathological examination revealed a poorly mucinous differentiated signet-ring cell adenocarcinoma with an intense peri-tumoral lymphoid (Crohn´s-like lymphoid reaction) and lympho-vascular infiltration with no nodal metastases (pT3N0;7ª edition TNM classification)...
February 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28209530/slc39a6-promotes-aggressiveness-of-esophageal-carcinoma-cells-by-increasing-intracellular-levels-of-zinc-activating-phosphatidylinositol-3-kinase-signaling-and-upregulating-genes-that-regulate-metastasis
#6
Xinxin Cheng, Lixuan Wei, Xudong Huang, Jian Zheng, Mingming Shao, Ting Feng, Jun Li, Yaling Han, Wenle Tan, Wen Tan, Dongxin Lin, Chen Wu
BACKGROUND & AIMS: A common variant in the solute carrier family 39 member 6 gene (SLC39A6) has been associated with survival times of patients with esophageal squamous-cell carcinoma (ESCC). We investigated the function of SLC39A6 and ways in which this variant affects tumor progression by studying ESCC samples and cell lines. METHODS: SLC39A6 was expressed, or knocked down by expression of small hairpin RNAs, in ESCC cells (KYSE30 and KYSE450) and HeLa cells using lentiviral vectors; we analyzed effects on proliferation, colony formation, migration, and invasion in vitro...
February 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28207963/nardilysin-promotes-hepatocellular-carcinoma-through-activation-of-signal-transducer-and-activator-of-transcription-3
#7
Yosuke Kasai, Kan Toriguchi, Etsuro Hatano, Kiyoto Nishi, Mikiko Ohno, Tomoaki Yoh, Keita Fukuyama, Takahiro Nishio, Masayuki Okuno, Keiko Iwaisako, Satoru Seo, Kojiro Taura, Masato Kurokawa, Makoto Kunichika, Shinji Uemoto, Eiichiro Nishi
Nardilysin (NRDC) is a metalloendopeptidase of the M16 family. We previously showed that NRDC activates inflammatory cytokine signaling, including interleukin-6-signal transducer and activator of transcription 3 (STAT3) signaling. NRDC has been implicated in the promotion of breast, gastric, and esophageal cancer, as well as the development of liver fibrosis. In this study, we investigated the role of NRDC in the promotion of hepatocellular carcinoma (HCC), both clinically and experimentally. We found that NRDC expression was up-regulated 3-fold in HCC tissue compared to the adjacent non-tumor liver tissue, which was confirmed by immunohistochemistry and western blotting...
February 16, 2017: Cancer Science
https://www.readbyqxmd.com/read/28206968/intratumoral-lactate-metabolism-in-barrett-s-esophagus-and-adenocarcinoma
#8
Heikki Huhta, Olli Helminen, Sami Palomäki, Joonas H Kauppila, Juha Saarnio, Petri P Lehenkari, Tuomo J Karttunen
BACKGROUND: Monocarboxylate transporters (MCTs) are cell membrane proteins which transport pyruvate, lactate and ketone bodies across the plasma membrane. MCTs are activated in various cancers, but their expression in esophageal adenocarcinoma is not known. The present study was conducted to elucidate the expression of MCTs in esophageal adenocarcinoma and its precursor lesions. RESULTS: Cytoplasmic MCT1, MCT4 and MTCO1 expression linearly increased from normal epithelium to Barrett's mucosa to dysplasia and cancer...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28204832/anti-proliferative-effect-of-jesridonin-on-paclitaxel-resistant-ec109-human-esophageal-carcinoma-cells
#9
Cong Wang, Liubin Guo, Saiqi Wang, Junwei Wang, Yongmei Li, Yinhui Dou, Ran Wang, Hongge Shi, Yu Ke, Hongmin Liu
Chemoresistance to anticancer drugs is a major obstacle in the efforts to develop a successful treatment strategy for esophageal squamous carcinoma (ESCC). Thus, the exploration of new drugs and treatment strategies for combating resistance are of utmost importance. In this study, we investigated the antitumor drug resistance activity of Jesridonin, a new ent-kaurene diterpenoid, and its possible mechanisms of action using the resistant cancer cell line, EC109/Taxol. MTT assay revealed that Jesridonin had similar IC50 values against EC109 paclitaxel-sensitive cells and drug-resistant EC109/Taxol cells in vitro...
March 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28197630/tnfaip3-overexpression-is-an-independent-factor-for-poor-survival-in-esophageal-squamous-cell-carcinoma
#10
Yuni Elsa Hadisaputri, Tatsuya Miyazaki, Takehiko Yokobori, Makoto Sohda, Makoto Sakai, Daigo Ozawa, Keigo Hara, Hiroaki Honjo, Yuji Kumakura, Hiroyuki Kuwano
Tumor necrosis factor α induced protein 3 (TNFAIP3) is a protein that is induced by TNF-mediated NF-κB activation and has a dual function in regulating NF-κB. TNFAIP3 is associated with inflammatory carcinogenesis in many cancer types. However, the clinical significance of TNFAIP3 expression and function in esophageal squamous cell carcinoma (ESCC) has not yet been reported. We examined 149 ESCC tissue specimens to determine the clinical significance of TNFAIP3 by immunohistochemistry. Western blot analyses were used to detect TNFAIP3 expression in TE-1, TE-8, TE-15 and KYSE-70 ESCC cells and in Het-1A, a non-cancerous esophageal cell line...
March 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28195186/neutrophil-to-lymphocyte-ratio-as-a-prognostic-biomarker-for-patients-with-locally-advanced-esophageal-squamous-cell-carcinoma-treated-with-definitive-chemoradiotherapy
#11
Xi-Lei Zhou, Yong-Qiang Li, Wei-Guo Zhu, Chang-Hua Yu, Ya-Qi Song, Wan-Wei Wang, Dong-Cheng He, Guang-Zhou Tao, Yu-Suo Tong
The present study evaluated the clinical and prognostic value of neutrophil-to-lymphocyte ratio (NLR) in patients with locally advanced esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (dCRT). A total of 517 patients with ESCC were enrolled and analysed retrospectively. The NLR was calculated at three time points: baseline, post-treatment, and at the time of tumor progression. Elevated NLR was defined as a ratio ≥5. High NLR at baseline was present in 204 (39%) patients and was significantly correlated with larger tumour size, advanced TNM stage, worse ECOG performance status, and dCRT response (p < 0...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194033/integrative-analyses-of-transcriptome-sequencing-identify-novel-functional-lncrnas-in-esophageal-squamous-cell-carcinoma
#12
C-Q Li, G-W Huang, Z-Y Wu, Y-J Xu, X-C Li, Y-J Xue, Y Zhu, J-M Zhao, M Li, J Zhang, J-Y Wu, F Lei, Q-Y Wang, S Li, C-P Zheng, B Ai, Z-D Tang, C-C Feng, L-D Liao, S-H Wang, J-H Shen, Y-J Liu, X-F Bai, J-Z He, H-H Cao, B-L Wu, M-R Wang, D-C Lin, H P Koeffler, L-D Wang, X Li, E-M Li, L-Y Xu
Long non-coding RNAs (lncRNAs) have a critical role in cancer initiation and progression, and thus may mediate oncogenic or tumor suppressing effects, as well as be a new class of cancer therapeutic targets. We performed high-throughput sequencing of RNA (RNA-seq) to investigate the expression level of lncRNAs and protein-coding genes in 30 esophageal samples, comprised of 15 esophageal squamous cell carcinoma (ESCC) samples and their 15 paired non-tumor tissues. We further developed an integrative bioinformatics method, denoted URW-LPE, to identify key functional lncRNAs that regulate expression of downstream protein-coding genes in ESCC...
February 13, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28193907/stem-cell-autocrine-cxcl12-cxcr4-stimulates-invasion-and-metastasis-of-esophageal-cancer
#13
Xingwei Wang, Yan Cao, Shirong Zhang, Zhihui Chen, Ling Fan, Xiaochun Shen, Shiwen Zhou, Dongfeng Chen
Esophageal cancer is one of the most common malignant tumors of the digestive tract. The greatest obstacle to the curing of esophageal cancer is its propensity to spread and metastasize. Esophageal cancer stem cells are considered the source for recurrence and metastasis of the tumors. While clinical evidence suggested that continuous up-regulation of CXCL12/CXCR4 was significantly associated with poor prognosis in patients with esophageal cancer, but the role and mechanism of CXCL12/CXCR4 in the invasion and metastasis of esophageal cancer has not been reported by far...
February 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28192623/pd-l1-is-prognostic-factor-in-esophageal-squamous-cell-carcinoma-and-is-associated-with-egfr
#14
Wencheng Zhang, Qingsong Pang, Xiaodong Zhang, Cihui Yan, Qifeng Wang, Jinsong Yang, Shufei Yu, Xiao Liu, Yi Pan, Zhiyong Yuan, Ping Wang, Zefen Xiao
Programmed death-ligand 1 (PD-L1) expression either indicates immune inhibitory status or concurrent immune response. Although the relationship between PD-L1 and clinical outcomes has been studied widely in recent years, its role in prognosis of esophageal squamous cell carcinoma (ESCC) remains unclear. Here, we assessed the significance of PD-L1 in ESCC and its association with epidermal growth factor receptor (EGFR) and radiation response. We found that PD-L1 was present both on the surface of tumor cells and tumor-infiltrating immune cells...
February 13, 2017: Cancer Science
https://www.readbyqxmd.com/read/28191296/dedifferentiated-liposarcoma-of-the-esophagus-a-case-report-and-selected-review-of-the-literature
#15
Christopher L Brett, Daniel H Miller, Liuyan Jiang, Herbert C Wolfsen, Steven Attia, Lauren Hintenlang, Niveditha Jagadesh, Robert C Miller
Soft tissue sarcomas of the esophagus represent an extremely rare cause of esophageal masses, and an even smaller proportion of these tumors represent dedifferentiated liposarcomas. We present a case of a 75-year-old gentleman presenting with dysphagia found to have a 5 cm pedunculated mass in the cervical esophagus, originating at the cricopharyngeus. This was found to have involvement limited to the superficial mucosa by endoscopic ultrasound, and the lesion was subsequently resected endoscopically. Pathology demonstrated an undifferentiated pleomorphic sarcoma later determined to represent dedifferentiated liposarcoma after fluorescence in situ hybridization analysis...
November 17, 2016: Rare Tumors
https://www.readbyqxmd.com/read/28188749/loss-of-par-3-protein-expression-is-associated-with-invasion-lymph-node-metastasis-and-poor-survival-in-esophageal-squamous-cell-carcinoma
#16
Tomoko Kitaichi, Kohichiroh Yasui, Yasuyuki Gen, Osamu Dohi, Naoto Iwai, Akira Tomie, Nobuhisa Yamada, Kei Terasaki, Atsushi Umemura, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Yoshio Sumida, Hironori Mitsuyoshi, Yuji Naito, Yoh Zen, Yoshito Itoh
Disrupted cell polarity is a feature of epithelial cancers. The partitioning defective 3 (PAR-3) protein, a key component of the PAR complex that regulates the polarization of cells, is involved in tight junction formation at epithelial cell-cell contacts. Our previous study detected a homozygous deletion of the PAR-3 gene in esophageal squamous cell carcinoma (ESCC) cell lines and frequent copy number loss of the PAR-3 gene in primary ESCC. Here, we aimed to investigate the clinicopathological relevance of altered expression of the PAR-3 protein in primary ESCC...
February 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/28188501/effect-of-extending-the-original-eligibility-criteria-for-the-cross-neoadjuvant-chemoradiotherapy-on-toxicity-and-survival-in-esophageal-cancer
#17
E C de Heer, J B Hulshoff, D Klerk, J G M Burgerhof, D J A de Groot, J Th M Plukker, G A P Hospers
BACKGROUND: Patients with curable esophageal cancer (EC) who proceed beyond the original Chemoradiotherapy for Oesophageal Cancer Followed by Surgery Study (CROSS) eligibility criteria are also treated with neoadjuvant chemoradiotherapy (nCRT). This study assessed the effect that extending the CROSS eligibility criteria for nCRT has on treatment-related toxicity and overall survival (OS) in EC. METHODS: The study enrolled 161 patients with locally advanced EC (T1N1-3/T2-4aN0-3/M0) treated with the CROSS schedule followed by esophagectomy...
February 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28187044/minimally-invasive-versus-open-esophageal-resection-three-year-follow-up-of-the-previously-reported-randomized-controlled-trial-the-time-trial
#18
Jennifer Straatman, Nicole van der Wielen, Miguel A Cuesta, Freek Daams, Josep Roig Garcia, Luigi Bonavina, Camiel Rosman, Mark I van Berge Henegouwen, Suzanne S Gisbertz, Donald L van der Peet
OBJECTIVE: The aim of this study was to investigate 3-year survival following a randomized controlled trial comparing minimally invasive with open esophagectomy in patients with esophageal cancer. BACKGROUND: Research on minimally invasive esophagectomy (MIE) has shown faster postoperative recovery and a marked decrease in pulmonary complications. Debate is ongoing as to whether the procedure is equivalent to open resection regarding oncologic outcomes. The study is a follow-up study of the TIME-trial (traditional invasive vs minimally invasive esophagectomy, a multicenter, randomized trial)...
February 9, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28185461/-epithelial-mesenchymal-transition-in-tumor-tissue-and-its-role-for-metastatic-spread-of-cancer
#19
V M Matějka, J Fínek, M Králíčková
BACKGROUND: Metastasis, recurrence, and resistance to chemotherapy are leading causes of the majority of cancer-related mortality worldwide. The process of metastasis can be artificially divided into a series of sequential, highly organized, and organ-specific steps. The underlying mechanisms are still poorly understood, but are believed to be mediated by epithelial-mesenchymal transition (EMT). First described in embryogenesis, EMT is a cellular reprogramming process in which epithelial cells acquire a mesenchymal phenotype...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28184939/interleukin-17a-promotes-esophageal-adenocarcinoma-cell-invasiveness-through-ros-dependent-nf-%C3%AE%C2%BAb-mediated-mmp-2-9-activation
#20
Dong Liu, Rong Zhang, Jie Wu, Yansong Pu, Xiaoran Yin, Yan Cheng, Jing Wu, Cheng Feng, Yumei Luo, Jun Zhang
Interleukin-17A (IL-17A), a pro-inflammatory cytokine secreted primarily by Th17 cells, has been proved to be involved in the microenvironment of certain inflammation-related tumors. However, the role of IL-17A in cancer development has always been controversial. In this study, we investigated the effect of IL-17A on the regulation of esophageal adenocarcinoma (EAC) cell invasiveness and related molecular mechanism. Surface IL-17 receptor (IL-17R) expression on human EAC cell line OE19 was examined using flow cytometry...
March 2017: Oncology Reports
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