H K Perlow, A Nalin, A Ritter, M Addington, A Ward, M Liu, C Nappi, D M Blakaj, S Beyer, E M Thomas, J C Grecula, R Raval, R Kotecha, D Boulter, E Dawson, W Zoller, J D Palmer
PURPOSE/OBJECTIVE(S): Recent advances to preserve neurocognitive function in patients treated for brain metastases include stereotactic radiosurgery (SRS), hippocampal avoidance whole brain radiation therapy (HA-WBRT), and memantine administration. However, 23% of patients receiving HA-WBRT and memantine on NRG-CC001 still experienced executive function deterioration at 4 months, with 12% experiencing total recall and delayed recognition deterioration at 6 months. The hippocampus, corpus callosum, fornix, and amygdala are key neurocognitive substructures with a low propensity for brain metastases...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics