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Yi-Chuan Xiao

Yuan-Yuan Ding, Xiao-Juan Gong, Yang Liu, Wen-Jing Lu, Yi-Fang Gao, Ming Xian, Shao-Min Shuang, Chuan Dong
Long wavelength (i.e., orange- to red-light) fluorescence emission and functionality are critically longing for the development and applications of carbon dots (CDs) toward biosensor and bioimaging analysis. Herein, the N-doped carbon dots (N-CDs) with bright orange fluorescence emission at 592 nm were facilely synthesized via p-phenylenediamine as a carbon precursor by microwave method. The as-prepared N-CDs exhibit favorable biocompatibility, excellent water solubility, highly optical stabilities and display sensitive pH response behavior...
November 1, 2018: Talanta
Yu Yang, Peng-Lei Xiao, Ya Yang, Jian-Chuan Gao, Yan Shi, Wan-Ting Cheng, Yue Chen, Xiu-Xia Song, Qing-Wu Jiang, Yi-Biao Zhou
Objective: To explore the association between infections with HIV and Schistosoma japonicum , and to determine the influences of the HIV- S. japonicum coinfections on the immune system of Yi people. Methods: A block design study was conducted in a Yi county in southwestern China, one of the endemic areas of both HIV/AIDS and S. japonicum in China. All participants were screened for HIV antibodies and S. japonicum antibodies (SjAb) and were classified into four groups: HIV(+)/ S...
2018: Journal of Immunology Research
Wayne R Lawrence, Mo Yang, Chuan Zhang, Ru-Qing Liu, Shao Lin, Si-Quan Wang, Yimin Liu, Huimin Ma, Duo-Hong Chen, Xiao-Wen Zeng, Bo-Yi Yang, Li-Wen Hu, Steve Hung Lam Yim, Guang-Hui Dong
No abstract text is available yet for this article.
July 24, 2018: Sleep
Fang-Yuan Mao, Yong-Liang Zhao, Yi-Pin Lv, Yong-Sheng Teng, Hui Kong, Yu-Gang Liu, Xiao-Long Wu, Chuan-Jie Hao, Weisan Chen, Mu-Bing Duan, Bin Han, Qiang Ma, Ting-Ting Wang, Liu-Sheng Peng, Jin-Yu Zhang, Ping Cheng, Chong-Yu Su, Xiao-Long Fu, Quan-Ming Zou, Gang Guo, Xiao-Lan Guo, Yuan Zhuang
Myeloid-derived suppressor cells (MDSCs) are a prominent component of the pro-tumoral response. The phenotype of and mechanisms used by MDSCs is heterogeneous and requires more precise characterization in gastric cancer (GC) patients. Here, we have identified a novel subset of CD45+ CD33low CD11bdim MDSCs in the peripheral blood of GC patients compared to healthy individuals. CD45+ CD33low CD11bdim MDSCs morphologically resembled neutrophils and expressed high levels of the neutrophil marker CD66b. Circulating CD45+ CD33low CD11bdim MDSCs effectively suppressed CD8+ T cells activity through the inhibition of CD8+ T cell proliferation and interferon-γ (IFN-γ) and granzyme B (GrB) production...
July 9, 2018: Cell Death & Disease
Mei-Juan Xu, Bo Bao, Chun-Yan Chen, Yong-Chuan Wang, Fu-Yan Gao, Xiao-Yi Yu
In order to evaluate the present situation and the potential ecological risk of heavy metal pollution in the surface waters of eastern Chinese coastal cities, the city of Ningbo was used as an example. From surface waters in Ningbo, 255 water samples were collected. The concentrations of six heavy metals (Cd, Cr, Cu, Ni, Pb, and Zn) were measured for the samples. The potential ecological risk of these heavy metals was evaluated by calculating health risk and cancer risk indices. The results indicate that, in the surface waters of Ningbo, the average concentrations of the six heavy metals were in the increasing order of Zn > Pb > Cr > Ni > Cd > Cu...
February 8, 2018: Huan Jing Ke Xue= Huanjing Kexue
Rui-Peng Tong, Lei Zhang, Xiao-Yi Yang, Xu-Bo Zhu, Chuan-Geng Ren
Regarding furniture manufacturing, scholars have only studied the sources of VOCs in the spraying process, yet the main concern is the release of VOCs after the completion of the manufacturing process and its impact on indoor air quality. Therefore, in this study, the sources of VOCs for the entire process of furniture manufacturing were explored and probabilistic risk models were improved. Then, the carcinogenicity and non-carcinogenic health risks to workers at nine workstations in a furniture factory were evaluated via a Monte Carlo simulation method, and the sensitivity of each exposure parameter was analyzed...
February 8, 2018: Huan Jing Ke Xue= Huanjing Kexue
Bo-Yi Yang, Zhengmin Min Qian, Michael G Vaughn, Steven W Howard, John Phillip Pemberton, Huimin Ma, Duo-Hong Chen, Li-Wen Hu, Xiao-Wen Zeng, Chuan Zhang, Yan-Peng Tian, Min Nian, Xiang Xiao, Guang-Hui Dong
BACKGROUND: Research regarding the interaction of ambient air pollution and overweight on prehypertension is scarce. We aimed to test whether overweight modifies the association between long-term exposure to ambient air pollution and prehypertension in Chinese adults. METHODS: A total of 16,188 Chinese adults, aged 18-74 years old, from 33 communities in 3 Northeastern Chinese cities were evaluated. Three-year average levels of particles with an aerodynamic diameter ≤ 10 μm (PM10 ), sulfur dioxides (SO2 ), nitrogen dioxides (NO2 ), and ozone (O3 ) were calculated at monitoring stations...
June 28, 2018: Environmental Health: a Global Access Science Source
Wayne R Lawrence, Mo Yang, Chuan Zhang, Ru-Qing Liu, Shao Lin, Si-Quan Wang, Yimin Liu, Huimin Ma, Duo-Hong Chen, Xiao-Wen Zeng, Bo-Yi Yang, Li-Wen Hu, Steve Hung Lam Yim, Guang-Hui Dong
Study Objectives: There is limited knowledge regarding the effects of air pollution on sleep disorders, particularly in children. The aim of this study is to investigate this association in Chinese children. Methods: During 2012-2013, 59754 children, aged 2-17 years were randomly selected from 27 districts in seven northeastern Chinese cities. All participants sleep was evaluated with the Sleep Disturbance Scale for Children. Four-year average concentrations of pollutants were calculated for particles with an aerodynamic diameter of ≤1µm (PM1), ≤2...
June 25, 2018: Sleep
Xing Deng, Xin Zhang, Weiping Li, Ren-Xin Feng, Lu Li, Gui-Rong Yi, Xiao-Nan Zhang, Chuan Yin, Hong-Yu Yu, Jun-Ping Zhang, Bin Lu, Lijian Hui, Wei-Fen Xie
Chronic liver injury can cause cirrhosis and impaired liver regeneration, impairing organ function. Adult livers can regenerate in response to parenchymal insults, and multiple cellular sources have been reported to contribute to this response. In this study, we modeled human chronic liver injuries, in which such responses are blunted, without genetic manipulations, and assessed potential contributions of non-parenchymal cells (NPCs) to hepatocyte regeneration. We show that NPC-derived hepatocytes replenish a large fraction of the liver parenchyma following severe injuries induced by long-term thioacetamide (TAA) or 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) treatment...
July 5, 2018: Cell Stem Cell
You-Yu Gu, Ping Huang, Quan Li, Yu-Ying Liu, George Liu, Yu-Hui Wang, Ming Yi, Li Yan, Xiao-Hong Wei, Lei Yang, Bai-He Hu, Xin-Rong Zhao, Xin Chang, Kai Sun, Chun-Shui Pan, Yuan-Chen Cui, Qing-Fang Chen, Chuan-She Wang, Jing-Yu Fan, Zhi-Zhong Ma, Jing-Yan Han
The purpose of the study was to explore the effect and the underlying mechanism of YangXue QingNao Wan (YXQNW) and Silibinin Capsules (SC), the two Chinese medicines, on cognitive impairment in older people with familial hyperlipidaemia. Fourteen month-old female LDLR (+/-) golden Syrian hamsters were used with their wild type as control. YXQNW (0.5 g/kg/day), SC (0.1 g/kg/day), or YXQNW (0.5 g/kg/day) + SC (0.1 g/kg/day) were administrated orally for 30 days. To assess the effects of the two drugs on plasma lipid content and cognitive ability, plasma TC, TG, LDL-C, and HDL-C were measured, and Y maze task was carried out both before and after administration...
2018: Frontiers in Physiology
Hong-Yu Yin, Chuan Wang, Zhi-Yong Zhang, Lei Shi, Lin Yin, Wei Liu, Shi Feng, Yi-Lin Cao, Xiao-Jun Tang
BACKGROUND: The relapse of hemifacial microsomia was thought to be highly related to the soft tissue envelope around the mandible angle mainly composed by masseter and medial pterygoid. According to the reason, we tried to apply masseter injection of type A botulinum toxin to weaken the soft envelope tension on the early stage post mandible distraction in adult HFM patients. METHODS: Eight patients diagnosed with HFM were studied and randomly assigned to an experimental or control group...
June 11, 2018: Journal of Craniofacial Surgery
Sha Li, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Xi Zhao, Di Sun, Xiong-Yi Gao, Ying Gao, Yan Zhang, Ping Qing, Xiao-Lin Li, Jing Sun, Geng Liu, Qian Dong, Rui-Xia Xu, Chuan-Jue Cui, Jian-Jun Li
Familial hypercholesterolemia (FH) is one of the most common causes of premature myocardial infarction (MI). However, The patterns of FH remained unrecognized in clinical care, especially in very young patients (VYPs, ≤35 years) with MI. The present study enrolled a total of 1,093 VYPs (≤35 years) presenting a first MI. Clinical diagnosis of FH was made using Dutch Lipid Clinic Network criteria. Coronary severity was assessed by Gensini score (GS). Patients were followed for a median of 40-months with cardiac death, stroke, MI, post-discharge revascularization or unstable angina as primary endpoints...
June 11, 2018: Scientific Reports
Man-Feng Zhang, Xiao-Lin Cai, Kai-Peng Jing, Xiao-Xue Pi, Pei-Yu Liao, Shi-Jie Li, Wen-Li, Chuan-Chuan Cai, Juan-Hua Quan, Yi-Ming Fan, Ge-Shi
Sebocyte differentiation is a continuous process, but its potential molecular mechanism remains unclear. We aimed to establish a novel sebocyte differentiation model using human primary sebocytes and to identify the expression profiles of differentiation-associated proteins. Primary human sebocytes were cultured on Sebomed medium supplemented with 2% serum for 7 days. Flow cytometry showed that S phase cells were decreased time-dependently, while G1 and subG1 (apoptosis) phase cells increased under serum starvation...
2018: BioMed Research International
Quan-Wei Wang, Xiao-Feng Yu, Hua-Li Xu, Yi-Chuan Jiang, Xue-Zhong Zhao, Da-Yuan Sui
Objective. Panax ginseng is widely used for treatment of cardiovascular disorders in China. Ginsenoside Re is the main chemical component of Panax ginseng . This study aimed to investigate the protective effect of Ginsenoside Re on isoproterenol-induced myocardial injury in rats. Methods. Male Wistar rats were orally given Ginsenoside Re (5, 20 mg/kg) daily for 7 days. Isoproterenol was subcutaneously injected into the rats for two consecutive days at a dosage of 20 mg/kg/day (on 6th and 7th day). Six hours after the last isoproterenol injection, troponin T level and creatine kinase-MB (CK-MB) activity were assayed...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Juan An, Chuan-Hao Tang, Na Wang, Yi Liu, Jin Lv, Bin Xu, Xiao-Yan Li, Wan-Feng Guo, Hong-Jun Gao, Kun He, Xiao-Qing Liu
Epidermal growth factor receptor (EGFR) mutation is an important predictor for response to personalized treatments of patients with advanced non-small-cell lung cancer (NSCLC). However its usage is limited due to the difficult of obtaining tissue specimens. A novel prediction system using matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been reported to be a perspective tool in European countries to identify patients who are likely to benefit from EGFR tyrosine kinase inhibitor (TKI) treatment...
June 2018: Oncology Letters
Shu-Ling Rong, Xiao-Lin Wang, Yi-Cheng Wang, Huan Wu, Xue-Dong Zhou, Ze-Kun Wang, Yu-Chuan Wang, Cun-Shui Xue, Bao Li, Dong-Lai Gao
Hepatocyte growth factor (HGF) alleviates acute and chronic inflammation in experimental inflammatory bowel disease, glomerulonephritis, and airway inflammation. However, the anti-inflammatory effects of HGF on myocardial infarction are not defined. The current study assessed the anti-inflammatory effects of HGF in post-ischemic heart failure. The left anterior descending coronary artery was ligated in rats, and adenovirus containing human HGF (Ad-HGF) or control virus (Ad-GFP) was administered intramyocardially...
May 24, 2018: Acta Pharmacologica Sinica
Yao Xiao, Can Wang, Jia-Yu Chen, Fujian Lu, Jue Wang, Ning Hou, Xiaomin Hu, Fanxin Zeng, Dongwei Ma, Xueting Sun, Yi Ding, Yan Zhang, Wen Zheng, Yuli Liu, Haibao Shang, Wenzhen Zhu, Chensheng Han, Yulin Zhang, Kunfu Ouyang, Liangyi Chen, Ju Chen, Rui-Ping Xiao, Chuan-Yun Li, Xiuqin Zhang
Hyperinsulinemia is the earliest symptom of insulin resistance (IR), but a causal relationship between the two remains to be established. Here we show that a protein kinase D2 (PRKD2) nonsense mutation (K410X) in two rhesus monkeys with extreme hyperinsulinemia along with IR and metabolic defects by using extreme phenotype sampling and deep sequencing analyses. This mutation reduces PRKD2 at both the mRNA and the protein levels. Taking advantage of a PRKD2-KO mouse model, we demonstrate that PRKD2 deletion triggers hyperinsulinemia which precedes to IR and metabolic disorders in the PRKD2 ablation mice...
May 22, 2018: Nature Communications
Wei Wang, Chuan Yang, Xiao Yi Wang, Li Yan Zhou, Guo Juan Lao, Dan Liu, Chuan Wang, Meng Die Hu, Ting Ting Zeng, Li Yan, Meng Ren
Diabetic wounds are recalcitrant to healing. However, the mechanism causing this dysfunction is not fully understood. High expression of matrix metalloproteinase-9 (MMP-9) is indicative of poor wound healing. In this study, we show that specificity protein-1 (Sp1), a regulator of MMP-9, binds directly to its promoter and enhances its expression. Additionally, we demonstrated that Sp1 is the direct target of two microRNAs (miRNAs), miR-129 and -335, which are significantly downregulated in diabetic skin tissues...
August 2018: Diabetes
Fei Han, Wen-Bin Liu, Xiao-Yan Shi, Jun-Tang Yang, Xi Zhang, Zhi-Ming Li, Xiao Jiang, Li Yin, Jian-Jun Li, Chuan-Shu Huang, Jia Cao, Jin-Yi Liu
Although high mortality of lung cancer is greatly due to distant metastasis, the mechanism of this metastasis remains unclear. Here, we investigate in lung cancer that SOX30 is sharply under-expressed in metastatic tumors compared with non-metastatic tumors, and suppresses plenty of metastasis related processes or pathways. SOX30 strongly inhibits tumor cell metastasis in vitro and in vivo. Sox30 deficiency promotes lung metastasis in Sox30-/- mice and this uncontrollable lung-metastasis is re-inhibited upon Sox30 re-expression...
May 2018: EBioMedicine
Wei Wang, Dian Lei, Yi-Chiau Huang, Kwang Hong Lee, Wan-Khai Loke, Yuan Dong, Shengqiang Xu, Chuan Seng Tan, Hong Wang, Soon-Fatt Yoon, Xiao Gong, Yee-Chia Yeo
We report the first demonstration of high-performance GeSn metal-semiconductor-metal (MSM) photodetector and GeSn p-type fin field-effect transistor (pFinFET) on an advanced GeSn-on-insulator (GeSnOI) platform by complementary metal-oxide-semiconductor (CMOS) compatible processes. The detection range of GeSn photodetector is extended beyond 2 µm, with responsivities of 0.39 and 0.10 A/W at 1550 nm and 2003 nm, respectively. Through the insertion of an ultrathin Al2 O3 Schottky-barrier-enhancement layer, the dark current IDark of the GeSn photodetector is suppressed by more than 2 orders of magnitude...
April 16, 2018: Optics Express
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