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https://www.readbyqxmd.com/read/30320193/cmhx008-a-ppar%C3%AE-partial-agonist-enhances-insulin-sensitivity-with-minor-influences-on-bone-loss
#1
Yi Hou, Xuemei Cao, Xiangnan Hu, Xinyu Li, Xiaoqin Shi, Hongying Wang, Chuan Peng, Jiayu Li, Jibin Li, Qifu Li, Chaodong Wu, Xiaoqiu Xiao
Traditional thiazolidinediones (TZDs), such as rosiglitazone, are peroxisome proliferator-activated receptor γ (PPARγ) potent agonists that can be used to treat type 2 diabetes but carry unwanted effects, including increased risk for fracture. The present work aimed to compare the insulin-sensitizing efficacies and bone-loss side effects of CMHX008, a novel TZDs-like PPARγ partial agonist, with those of rosiglitazone. A TR-FRET PPARγ competitive binding assay was used to compare the binding affinity between CMHX008 and rosiglitazone...
September 2018: Genes & Diseases
https://www.readbyqxmd.com/read/30319983/guidelines-for-diagnosis-and-treatment-of-primary-liver-cancer-in-china-2017-edition
#2
Jian Zhou, Hui-Chuan Sun, Zheng Wang, Wen-Ming Cong, Jian-Hua Wang, Meng-Su Zeng, Jia-Mei Yang, Ping Bie, Lian-Xin Liu, Tian-Fu Wen, Guo-Hong Han, Mao-Qiang Wang, Rui-Bao Liu, Li-Gong Lu, Zheng-Gang Ren, Min-Shan Chen, Zhao-Chong Zeng, Ping Liang, Chang-Hong Liang, Min Chen, Fu-Hua Yan, Wen-Ping Wang, Yuan Ji, Wen-Wu Cheng, Chao-Liu Dai, Wei-Dong Jia, Ya-Ming Li, Ye-Xiong Li, Jun Liang, Tian-Shu Liu, Guo-Yue Lv, Yi-Lei Mao, Wei-Xin Ren, Hong-Cheng Shi, Wen-Tao Wang, Xiao-Ying Wang, Bao-Cai Xing, Jian-Ming Xu, Jian-Yong Yang, Ye-Fa Yang, Sheng-Long Ye, Zheng-Yu Yin, Bo-Heng Zhang, Shui-Jun Zhang, Wei-Ping Zhou, Ji-Ye Zhu, Rong Liu, Ying-Hong Shi, Yong-Sheng Xiao, Zhi Dai, Gao-Jun Teng, Jian-Qiang Cai, Wei-Lin Wang, Jia-Hong Dong, Qiang Li, Feng Shen, Shu-Kui Qin, Jia Fan
Background: Hepatocellular carcinoma (HCC) (about 85-90% of primary liver cancer) is particularly prevalent in China because of the high prevalence of chronic hepatitis B infection. HCC is the fourth most common malignancy and the third leading cause of tumor-related deaths in China. It poses a significant threat to the life and health of Chinese people. Summary: This guideline presents official recommendations of the National Health and Family Planning Commission of the People's Republic of China on the surveillance, diagnosis, staging, and treatment of HCC occurring in China...
September 2018: Liver Cancer
https://www.readbyqxmd.com/read/30306806/effect-of-laterality-gender-age-and-body-mass-index-on-the-fat-fraction-of-salivary-glands-in-healthy-volunteers-assessed-using-iterative-decomposition-of-water-and-fat-with-echo-asymmetry-and-least-squares-estimation-method
#3
Guo-Yi Su, Chuan-Bing Wang, Hao Hu, Jun Liu, Hong-Yuan Ding, Xiao-Quan Xu, Fei-Yun Wu
OBJECTIVE: To evaluate the effect of laterality, gender, age and body mass index (BMI) on fat fraction (FF) measurements of both parotid glands (PGs) and submandibular glands (SMGs) by using : Iterative decomposition of water and fat with echo asymmetry and least-squares estimation method (IDEAL-IQ). METHODS: A total of 87 healthy participants were enrolled in our study. IDEAL-IQ image was scanned using a 3.0 T scanner. Paired t test was performed to compare the difference on FF of both PGs and SMGs between left and right side...
October 11, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/30305610/degranulation-of-mast-cells-induced-by-gastric-cancer-derived-adrenomedullin-prompts-gastric-cancer-progression
#4
Yi-Pin Lv, Liu-Sheng Peng, Qi-Hong Wang, Na Chen, Yong-Sheng Teng, Ting-Ting Wang, Fang-Yuan Mao, Jin-Yu Zhang, Ping Cheng, Yu-Gang Liu, Hui Kong, Xiao-Long Wu, Chuan-Jie Hao, Weisan Chen, Jiang Zhu, Bin Han, Qiang Ma, Ke Li, Quanming Zou, Yuan Zhuang
Mast cells are prominent components of solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, their precise mechanism of communication in gastric cancer remains largely unclear. Here, we found that patients with GC showed a significantly higher mast cell infiltration in tumors. Mast cell levels increased with tumor progression and independently predicted reduced overall survival. Tumor-derived adrenomedullin (ADM) induced mast cell degranulation via PI3K-AKT signaling pathway, which effectively promoted the proliferation and inhibited the apoptosis of GC cells in vitro and contributed to the growth and progression of GC tumors in vivo, and the effect could be reversed by blocking interleukin (IL)-17A production from these mast cells...
October 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/30275771/the-experimental-study-of-shunt-decompression-arterialized-vein-flap
#5
Zheng Li, Zhen-Wei Zhang, Shao-Xiao Yu, Jia-Chuan Zhuang, Yu-Hai Ke, Yi Xiong, Hui-Xin Lin, Wen-Feng Chen
Background: Arterialized vein flap is a kind of unphysiological flap. Unphysiological reconstruction of blood circulation leads to higher load than that supported by physiological flap and is the culprit of flap swelling, blood stasis, skin blistering, and necrosis after flap grafting. To resolve the multiple disadvantages of traditional flap grafting, by introducing the principles of fluid mechanics, shunt-decompression surgery is prepared to decline the circulation preload and improve the prognosis of arterialized vein flap grafting...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/30275345/hsp70-interacts-with-mapk-activated-protein-kinase-2-to-regulate-p38mapk-stability-and-myoblast-differentiation-during-skeletal-muscle-regeneration
#6
Wei Fan, Xiu Kui Gao, Xi Sheng Rao, Yin Pu Shi, Xiao Ceng Liu, Fei Ya Wang, Yu Fen Liu, Xiao Xia Cong, Min Yi He, Shui Bo Xu, Wei Liang Shen, Yue Shen, Shi Gui Yan, Yan Luo, Boon Chuan Low, Hongwei Ouyang, Zhang Bao, Li Ling Zheng, Yi Ting Zhou
The regenerative process of injured muscle is dependent on the fusion and differentiation of myoblast cells derived from muscle stem cells. Hsp70 is important for maintaining skeletal muscle homeostasis and regeneration but the precise cellular mechanism remains elusive. Here we found that Hsp70 was upregulated during myoblast differentiation. Depletion or inhibition of Hsp70/Hsc70 impaired myoblast differentiation. Importantly, overexpression of p38MAPKα, but not AKT1, rescued the impairment of myogenic differentiation in Hsp70- or Hsc70-depleted myoblasts...
October 1, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30267683/two-likely-auto-tetraploidization-events-shaped-kiwifruit-genome-and-contributed-to-establishment-of-the-actinidiaceae-family
#7
Jin-Peng Wang, Ji-Gao Yu, Jing Li, Peng-Chuan Sun, Li Wang, Jia-Qing Yuan, Fan-Bo Meng, Sang-Rong Sun, Yu-Xian Li, Tian-Yu Lei, Yu-Xin Pan, Wei-Na Ge, Zhen-Yi Wang, Lan Zhang, Xiao-Ming Song, Chao Liu, Xue-Qian Duan, Shao-Qi Shen, Yang-Qin Xie, Yue Hou, Jin Zhang, Jian-Yu Wang, Xiyin Wang
The genome of kiwifruit (Actinidia chinensis) was sequenced previously, the first in the Actinidiaceae family. It was shown to have been affected by polyploidization events, the nature of which has been elusive. Here, we performed a reanalysis of the genome and found clear evidence of 2 tetraploidization events, with one occurring ∼50-57 million years ago (Mya) and the other ∼18-20 Mya. Two subgenomes produced by each event have been under balanced fractionation. Moreover, genes were revealed to express in a balanced way between duplicated copies of chromosomes...
September 28, 2018: iScience
https://www.readbyqxmd.com/read/30255299/a-case-control-study-on-the-prevalence-of-enterovirus-in-children-samples-and-its-association-with-diarrhea
#8
Xin-Xin Shen, Fang-Zhou Qiu, Gui-Xia Li, Meng-Chuan Zhao, Ji Wang, Chen Chen, Li Zhao, Ju-Ju Qi, Hong Liu, Yi Zhang, Xiao-Zhou He, Le Wang, Zhi-Shan Feng, Xue-Jun Ma
Some serotypes of enterovirus (EV) may lead to transient and symptomatic gastrointestinal infections while others are commensal residents of the human gut. To determine whether certain EV types are more often associated with diarrhea, we conducted a preliminary study on the prevalence of EV serotypes and common diarrhea viruses in fecal samples of diarrhea children and healthy controls. EV was tested with one step nest polymerase chain reaction and typed by direct sequencing while common causative diarrhea viruses rotavirus (RV), norovirus (NoV), adenovirus (AdV), bocavirus (HBoV), and astrovirus (AstV) were screened with multiplex PCR assays...
September 25, 2018: Archives of Virology
https://www.readbyqxmd.com/read/30237471/copper-on-nitride-enhances-the-stable-electrosynthesis-of-multi-carbon-products-from-co-2
#9
Zhi-Qin Liang, Tao-Tao Zhuang, Ali Seifitokaldani, Jun Li, Chun-Wei Huang, Chih-Shan Tan, Yi Li, Phil De Luna, Cao Thang Dinh, Yongfeng Hu, Qunfeng Xiao, Pei-Lun Hsieh, Yuhang Wang, Fengwang Li, Rafael Quintero-Bermudez, Yansong Zhou, Peining Chen, Yuanjie Pang, Shen-Chuan Lo, Lih-Juann Chen, Hairen Tan, Zheng Xu, Suling Zhao, David Sinton, Edward H Sargent
Copper-based materials are promising electrocatalysts for CO2 reduction. Prior studies show that the mixture of copper (I) and copper (0) at the catalyst surface enhances multi-carbon products from CO2 reduction; however, the stable presence of copper (I) remains the subject of debate. Here we report a copper on copper (I) composite that stabilizes copper (I) during CO2 reduction through the use of copper nitride as an underlying copper (I) species. We synthesize a copper-on-nitride catalyst that exhibits a Faradaic efficiency of 64 ± 2% for C2+ products...
September 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/30215286/effects-of-brain-temperature-on-the-outcome-of-patients-with-traumatic-brain-injury-a-prospective-observational-study
#10
Wei-Ji Weng, Chun Yang, Xian-Jian Huang, Yong-Ming Zhang, Jin-Fang Liu, Jie-Min Yao, Zi-Heng Zhang, Xue-Song Wu, Tao Mei, Chuan-Dong Zhang, Jun Jia, Xiao-Feng Shi, Qing Mao, Jun-Feng Feng, Guo-Yi Gao, Ji-Yao Jiang
A prospective observational study collected temperature data from 51 patients in 11 neurosurgical centers and follow-up outcome information at 6 months in 49 patients. Brain temperature (Tbr ) was measured directly by an intraventricular temperature sensor. Axillary temperature (Tax ) and rectal temperature (Tre ) were measured by electric thermometers. Tbr was 0.4 to 1.5°C higher than body temperature. Tre correlated well with the Tbr (coefficient: 0.7378; p < 0.05). Among all patients, Glasgow Coma Scale (GCS) scores on admission were significantly lower in the patients with post-operatively extreme peak temperature (Tpeak , < 37°C or >39°C in first 24 h) and major temperature variation (Tvari > 1°C in first 12 h; p < 0...
October 10, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/30143602/multiplexed-storage-and-real-time-manipulation-based-on-a-multiple-degree-of-freedom-quantum-memory
#11
Tian-Shu Yang, Zong-Quan Zhou, Yi-Lin Hua, Xiao Liu, Zong-Feng Li, Pei-Yun Li, Yu Ma, Chao Liu, Peng-Jun Liang, Xue Li, Yi-Xin Xiao, Jun Hu, Chuan-Feng Li, Guang-Can Guo
The faithful storage and coherent manipulation of quantum states with matter-systems would enable the realization of large-scale quantum networks based on quantum repeaters. To achieve useful communication rates, highly multimode quantum memories are required to construct a multiplexed quantum repeater. Here, we present a demonstration of on-demand storage of orbital-angular-momentum states with weak coherent pulses at the single-photon-level in a rare-earth-ion-doped crystal. Through the combination of this spatial degree-of-freedom (DOF) with temporal and spectral degrees of freedom, we create a multiple-DOF memory with high multimode capacity...
August 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/30120361/allosteric-mechanisms-underlie-gpcr-signaling-to-sh3-domain-proteins-through-arrestin
#12
Fan Yang, Peng Xiao, Chang-Xiu Qu, Qi Liu, Liu-Yang Wang, Zhi-Xin Liu, Qing-Tao He, Chuan Liu, Jian-Ye Xu, Rui-Rui Li, Meng-Jing Li, Qing Li, Xu-Zhen Guo, Zhao-Ya Yang, Dong-Fang He, Fan Yi, Ke Ruan, Yue-Mao Shen, Xiao Yu, Jin-Peng Sun, Jiangyun Wang
Signals from 800 G-protein-coupled receptors (GPCRs) to many SH3 domain-containing proteins (SH3-CPs) regulate important physiological functions. These GPCRs may share a common pathway by signaling to SH3-CPs via agonist-dependent arrestin recruitment rather than through direct interactions. In the present study, 19 F-NMR and cellular studies revealed that downstream of GPCR activation engagement of the receptor-phospho-tail with arrestin allosterically regulates the specific conformational states and functional outcomes of remote β-arrestin 1 proline regions (PRs)...
September 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/30119544/gesn-lateral-p-i-n-photodetector-on-insulating-substrate
#13
Shengqiang Xu, Yi-Chiau Huang, Kwang Hong Lee, Wei Wang, Yuan Dong, Dian Lei, Saeid Masudy-Panah, Chuan Seng Tan, Xiao Gong, Yee-Chia Yeo
We report the first experimental demonstration of germanium-tin (GeSn) lateral p-i-n photodetector on a novel GeSn-on-insulator (GeSnOI) substrate. The GeSnOI is formed by direct wafer bonding and layer transfer technique, which is promising for large-scale integration of nano-electronics and photonics devices. The fabricated GeSnOI photodetector shows well-behaved diode characteristics with high Ion /Ioff ratio of ~4 orders of magnitude (at ± 1 V) at room temperature. A cutoff detection beyond 2 µm with photo responsivity (Rop ) of 0...
June 25, 2018: Optics Express
https://www.readbyqxmd.com/read/30086979/facile-preparation-of-bright-orange-fluorescent-carbon-dots-and-the-constructed-biosensing-platform-for-the-detection-of-ph-in-living-cells
#14
Yuan-Yuan Ding, Xiao-Juan Gong, Yang Liu, Wen-Jing Lu, Yi-Fang Gao, Ming Xian, Shao-Min Shuang, Chuan Dong
Long wavelength (i.e., orange- to red-light) fluorescence emission and functionality are critically longing for the development and applications of carbon dots (CDs) toward biosensor and bioimaging analysis. Herein, the N-doped carbon dots (N-CDs) with bright orange fluorescence emission at 592 nm were facilely synthesized via p-phenylenediamine as a carbon precursor by microwave method. The as-prepared N-CDs exhibit favorable biocompatibility, excellent water solubility, highly optical stabilities and display sensitive pH response behavior...
November 1, 2018: Talanta
https://www.readbyqxmd.com/read/30057918/immune-dysfunction-and-coinfection-with-human-immunodeficiency-virus-and-schistosoma-japonicum-in-yi-people
#15
Yu Yang, Peng-Lei Xiao, Ya Yang, Jian-Chuan Gao, Yan Shi, Wan-Ting Cheng, Yue Chen, Xiu-Xia Song, Qing-Wu Jiang, Yi-Biao Zhou
Objective: To explore the association between infections with HIV and Schistosoma japonicum , and to determine the influences of the HIV- S. japonicum coinfections on the immune system of Yi people. Methods: A block design study was conducted in a Yi county in southwestern China, one of the endemic areas of both HIV/AIDS and S. japonicum in China. All participants were screened for HIV antibodies and S. japonicum antibodies (SjAb) and were classified into four groups: HIV(+)/ S...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/30053274/association-between-long-term-exposure-to-air-pollution-and-sleep-disorder-in-chinese-children-the-seven-northeastern-cities-study
#16
Wayne R Lawrence, Mo Yang, Chuan Zhang, Ru-Qing Liu, Shao Lin, Si-Quan Wang, Yimin Liu, Huimin Ma, Duo-Hong Chen, Xiao-Wen Zeng, Bo-Yi Yang, Li-Wen Hu, Steve Hung Lam Yim, Guang-Hui Dong
No abstract text is available yet for this article.
September 1, 2018: Sleep
https://www.readbyqxmd.com/read/29988030/cd45-cd33-low-cd11b-dim-myeloid-derived-suppressor-cells-suppress-cd8-t-cell-activity-via-the-il-6-il-8-arginase-i-axis-in-human-gastric-cancer
#17
Fang-Yuan Mao, Yong-Liang Zhao, Yi-Pin Lv, Yong-Sheng Teng, Hui Kong, Yu-Gang Liu, Xiao-Long Wu, Chuan-Jie Hao, Weisan Chen, Mu-Bing Duan, Bin Han, Qiang Ma, Ting-Ting Wang, Liu-Sheng Peng, Jin-Yu Zhang, Ping Cheng, Chong-Yu Su, Xiao-Long Fu, Quan-Ming Zou, Gang Guo, Xiao-Lan Guo, Yuan Zhuang
Myeloid-derived suppressor cells (MDSCs) are a prominent component of the pro-tumoral response. The phenotype of and mechanisms used by MDSCs is heterogeneous and requires more precise characterization in gastric cancer (GC) patients. Here, we have identified a novel subset of CD45+ CD33low CD11bdim MDSCs in the peripheral blood of GC patients compared to healthy individuals. CD45+ CD33low CD11bdim MDSCs morphologically resembled neutrophils and expressed high levels of the neutrophil marker CD66b. Circulating CD45+ CD33low CD11bdim MDSCs effectively suppressed CD8+ T cells activity through the inhibition of CD8+ T cell proliferation and interferon-γ (IFN-γ) and granzyme B (GrB) production...
July 9, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29964836/-assessment-of-heavy-metal-pollution-and-human-health-risk-of-surface-waters-in-the-city-of-ningbo-china
#18
Mei-Juan Xu, Bo Bao, Chun-Yan Chen, Yong-Chuan Wang, Fu-Yan Gao, Xiao-Yi Yu
In order to evaluate the present situation and the potential ecological risk of heavy metal pollution in the surface waters of eastern Chinese coastal cities, the city of Ningbo was used as an example. From surface waters in Ningbo, 255 water samples were collected. The concentrations of six heavy metals (Cd, Cr, Cu, Ni, Pb, and Zn) were measured for the samples. The potential ecological risk of these heavy metals was evaluated by calculating health risk and cancer risk indices. The results indicate that, in the surface waters of Ningbo, the average concentrations of the six heavy metals were in the increasing order of Zn > Pb > Cr > Ni > Cd > Cu...
February 8, 2018: Huan Jing Ke Xue= Huanjing Kexue
https://www.readbyqxmd.com/read/29964830/-source-analysis-and-environmental-health-risk-assessment-of-vocs-in-furniture-manufacturing
#19
Rui-Peng Tong, Lei Zhang, Xiao-Yi Yang, Xu-Bo Zhu, Chuan-Geng Ren
Regarding furniture manufacturing, scholars have only studied the sources of VOCs in the spraying process, yet the main concern is the release of VOCs after the completion of the manufacturing process and its impact on indoor air quality. Therefore, in this study, the sources of VOCs for the entire process of furniture manufacturing were explored and probabilistic risk models were improved. Then, the carcinogenicity and non-carcinogenic health risks to workers at nine workstations in a furniture factory were evaluated via a Monte Carlo simulation method, and the sensitivity of each exposure parameter was analyzed...
February 8, 2018: Huan Jing Ke Xue= Huanjing Kexue
https://www.readbyqxmd.com/read/29954383/overweight-modifies-the-association-between-long-term-ambient-air-pollution-and-prehypertension-in-chinese-adults-the-33-communities-chinese-health-study
#20
Bo-Yi Yang, Zhengmin Min Qian, Michael G Vaughn, Steven W Howard, John Phillip Pemberton, Huimin Ma, Duo-Hong Chen, Li-Wen Hu, Xiao-Wen Zeng, Chuan Zhang, Yan-Peng Tian, Min Nian, Xiang Xiao, Guang-Hui Dong
BACKGROUND: Research regarding the interaction of ambient air pollution and overweight on prehypertension is scarce. We aimed to test whether overweight modifies the association between long-term exposure to ambient air pollution and prehypertension in Chinese adults. METHODS: A total of 16,188 Chinese adults, aged 18-74 years old, from 33 communities in 3 Northeastern Chinese cities were evaluated. Three-year average levels of particles with an aerodynamic diameter ≤ 10 μm (PM10 ), sulfur dioxides (SO2 ), nitrogen dioxides (NO2 ), and ozone (O3 ) were calculated at monitoring stations...
June 28, 2018: Environmental Health: a Global Access Science Source
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