keyword
https://read.qxmd.com/read/38421081/neuromorphic-nanoionics-for-human-machine-interaction-from-materials-to-applications
#1
REVIEW
Xuerong Liu, Cui Sun, Xiaoyu Ye, Xiaojian Zhu, Cong Hu, Hongwei Tan, Shang He, Mengjie Shao, Run-Wei Li
Human-machine interaction (HMI) technology has undergone significant advancements in recent years, enabling seamless communication between humans and machines. Its expansion has extended into various emerging domains, including human healthcare, machine perception, and biointerfaces, thereby magnifying the demand for advanced intelligent technologies. Neuromorphic computing, a paradigm rooted in nanoionic devices that emulate the operations and architecture of the human brain, has emerged as a powerful tool for highly efficient information processing...
February 29, 2024: Advanced Materials
https://read.qxmd.com/read/38191616/author-correction-perioperative-toripalimab-and-chemotherapy-in-locally-advanced-gastric-or-gastro-esophageal-junction-cancer-a-randomized-phase-2-trial
#2
Shu-Qiang Yuan, Run-Cong Nie, Ying Jin, Cheng-Cai Liang, Yuan-Fang Li, Rui Jian, Xiao-Wei Sun, Ying-Bo Chen, Wen-Long Guan, Zi-Xian Wang, Hai-Bo Qiu, Wei Wang, Shi Chen, Dong-Sheng Zhang, Yi-Hong Ling, Shao-Yan Xi, Mu-Yan Cai, Chun-Yu Huang, Qiu-Xia Yang, Zhi-Min Liu, Yuan-Xiang Guan, Yong-Ming Chen, Ji-Bin Li, Xiong-Wen Tang, Jun-Sheng Peng, Zhi-Wei Zhou, Rui-Hua Xu, Feng Wang
No abstract text is available yet for this article.
February 2024: Nature Medicine
https://read.qxmd.com/read/38181005/the-diagnostic-value-of-gica-used-for-intraoperative-lymph-node-fna-tg-measurement-to-evaluate-thyroid-cancer-metastases
#3
JOURNAL ARTICLE
Shaodong Hou, Yiceng Sun, Zeyu Yang, Mi Tang, Tingjie Yin, Cong Shao, Cunye Yan, Linlong Mo, Yuquan Yuan, Supeng Yin, Fan Zhang
OBJECTIVE: It is crucial to diagnose lymph node (LN) metastases (LNM) before or during thyroid carcinoma surgery. Measurement of thyroglobulin (Tg) in fine-needle aspirate washout (FNA-Tg) is useful to assist in the diagnosis of LNM for papillary thyroid carcinoma (PTC). This study aimed to assess the diagnostic performance of a new technique based on a colloidal gold-based immunochromatographic assay (GICA) for intraoperative FNA-Tg in diagnosing LNM. METHODS: This prospective study enrolled 51 PTC patients who underwent cervical LN dissection...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38167937/perioperative-toripalimab-and-chemotherapy-in-locally-advanced-gastric-or-gastro-esophageal-junction-cancer-a-randomized-phase-2-trial
#4
RANDOMIZED CONTROLLED TRIAL
Shu-Qiang Yuan, Run-Cong Nie, Ying Jin, Cheng-Cai Liang, Yuan-Fang Li, Rui Jian, Xiao-Wei Sun, Ying-Bo Chen, Wen-Long Guan, Zi-Xian Wang, Hai-Bo Qiu, Wei Wang, Shi Chen, Dong-Sheng Zhang, Yi-Hong Ling, Shao-Yan Xi, Mu-Yan Cai, Chun-Yu Huang, Qiu-Xia Yang, Zhi-Min Liu, Yuan-Xiang Guan, Yong-Ming Chen, Ji-Bin Li, Xiong-Wen Tang, Jun-Sheng Peng, Zhi-Wei Zhou, Rui-Hua Xu, Feng Wang
Perioperative chemotherapy is the standard treatment for locally advanced gastric or gastro-esophageal junction cancer, and the addition of programmed cell death 1 (PD-1) inhibitor is under investigation. In this randomized, open-label, phase 2 study (NEOSUMMIT-01), patients with resectable gastric or gastro-esophageal junction cancer clinically staged as cT3-4aN + M0 were randomized (1:1) to receive either three preoperative and five postoperative 3-week cycles of SOX/XELOX (chemotherapy group, n = 54) or PD-1 inhibitor toripalimab plus SOX/XELOX, followed by toripalimab monotherapy for up to 6 months (toripalimab plus chemotherapy group, n = 54)...
February 2024: Nature Medicine
https://read.qxmd.com/read/38161496/expert-consensus-on-pathological-diagnosis-of-intrahepatic-cholangiocarcinoma-2022-version
#5
JOURNAL ARTICLE
Han Wang, Jun Chen, Xin Zhang, Xia Sheng, Xiao-Yan Chang, Jie Chen, Min-Shan Chen, Hui Dong, Guang-Jie Duan, He-Ping Hu, Zhi-Yong Huang, Wei-Dong Jia, Xiao-Qing Jiang, Dong Kuang, Shan-Shan Li, Zeng-Shan Li, Chang-Li Lu, Shu-Kui Qin, Xue-Shan Qiu, Li-Juan Qu, Chun-Kui Shao, Feng Shen, Guo-Ming Shi, Su-Sheng Shi, Yu-Jun Shi, Hui-Chuan Sun, Xiao-Dong Teng, Bin Wang, Zhan-Bo Wang, Tian-Fu Wen, Jia-Mei Yang, Qiao-Qiao Yang, Sheng-Long Ye, Hong-Fang Yin, Zhen-Gang Yuan, Jing-Ping Yun, Feng-Lin Zang, Hong-Qi Zhang, Li-Hong Zhang, Jing-Min Zhao, Jian Zhou, Wei-Xun Zhou, Jia Fan, Xiao-Ping Chen, Wan Yee Lau, Yuan Ji, Wen-Ming Cong
Intrahepatic cholangiocarcinoma (iCCA) can originate from the large bile duct group (segment bile ducts and area bile ducts), small bile duct group (septal bile ducts and interlobular bile ducts), and terminal bile duct group (bile ductules and canals of Hering) of the intrahepatic biliary tree, which can be histopathological corresponding to large duct type iCCA, small duct type iCCA and iCCA with ductal plate malformation pattern, and cholangiolocarcinoma, respectively. The challenge in pathological diagnosis of above subtypes of iCCA falls in the distinction of cellular morphologies, tissue structures, growth patterns, invasive behaviors, immunophenotypes, molecular mutations, and surgical prognoses...
December 28, 2023: Journal of Clinical and Translational Hepatology
https://read.qxmd.com/read/38144837/insights-into-the-volatile-flavor-and-quality-profiles-of-loquat-eriobotrya-japonica-lindl-during-shelf-life-via-hs-gc-ims-e-nose-and-e-tongue
#6
JOURNAL ARTICLE
Gui-Li Huang, Tian-Tian Liu, Xiao-Mei Mao, Xin-Yao Quan, Si-Yao Sui, Jia-Jia Ma, Ling-Xiang Sun, Hao-Cong Li, Qian-Shuo Shao, Yu-Ning Wang
Loquat fruits are among the most popular Chinese fruits because of their unique taste and aroma. The quality profiles of these fruits during 18 days of shelf-life at 20 °C were elucidated by headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS), E-nose, and E-tongue. During shelf-life period, the properties and variations of 43 (20 aldehydes, 7 esters, 6 ketones, 1 alcohol, and 1 furan) volatile flavored compounds were determined by GC-IMS, which showed that the contents of methyl 3-methyl butanoate, ethyl acetate, and dimethyl ketone gradually decrease with prolonged shelf-life time, while (E)-2-heptenal, heptanal, (E)-2-pentenal, 1-penten-3-one 3-pentanone and 2-pentylfuran increase...
December 30, 2023: Food chemistry: X
https://read.qxmd.com/read/38057566/a-chromosome-level-genome-assembly-for-the-silkie-chicken-resolves-complete-sequences-for-key-chicken-metabolic-reproductive-and-immunity-genes
#7
JOURNAL ARTICLE
Feng Zhu, Zhong-Tao Yin, Qiang-Sen Zhao, Yun-Xiao Sun, Yu-Chen Jie, Jacqueline Smith, Yu-Ze Yang, David W Burt, Maxwell Hincke, Zi-Ding Zhang, Meng-Di Yuan, Jim Kaufman, Cong-Jiao Sun, Jun-Ying Li, Li-Wa Shao, Ning Yang, Zhuo-Cheng Hou
A set of high-quality pan-genomes would help identify important genes that are still hidden/incomplete in bird reference genomes. In an attempt to address these issues, we have assembled a de novo chromosome-level reference genome of the Silkie (Gallus gallus domesticus), which is an important avian model for unique traits, like fibromelanosis, with unclear genetic foundation. This Silkie genome includes the complete genomic sequences of well-known, but unresolved, evolutionarily, endocrinologically, and immunologically important genes, including leptin, ovocleidin-17, and tumor-necrosis factor-α...
December 6, 2023: Communications Biology
https://read.qxmd.com/read/38008225/engineering-photo-methylotrophic-methylobacterium-for-enhanced-3-hydroxypropionic-acid-production-during-non-growth-stage-fermentation
#8
JOURNAL ARTICLE
Zeng-Xin Ma, Chen-Xi Feng, Ya-Zhen Song, Jing Sun, Yi Shao, Shu-Zhen Song, Bin Wan, Cong Zhang, Huan Fan, Kai Bao, Song Yang
This study explored the potential of methanol as a sustainable feedstock for biomanufacturing, focusing on Methylobacterium extorquens, a well-established representative of methylotrophic cell factories. Despite this bacterium's long history, its untapped photosynthetic capabilities for production enhancement have remained unreported. Using genome-scale flux balance analysis, it was hypothesized that introducing photon fluxes could boost the yield of 3-hydroxypropionic acid (3-HP), an energy- and reducing equivalent-consuming chemicals...
November 24, 2023: Bioresource Technology
https://read.qxmd.com/read/37920504/multi-omics-reveals-aging-related-pathway-in-natural-aging-mouse-liver
#9
JOURNAL ARTICLE
Cong-Min Tang, Zhen Zhang, Yan Sun, Wen-Jing Ding, Xue-Chun Yang, Yi-Ping Song, Ming-Ying Ling, Xue-Hui Li, Rong Yan, Yu-Jing Zheng, Na Yu, Wen-Hua Zhang, Yong Wang, Shao-Peng Wang, Hai-Qing Gao, Chuan-Li Zhao, Yan-Qiu Xing
Aging is associated with gradual changes in liver structure, altered metabolites and other physiological/pathological functions in hepatic cells. However, its characterized phenotypes based on altered metabolites and the underlying biological mechanism are unclear. Advancements in high-throughput omics technology provide new opportunities to understand the pathological process of aging. Here, in our present study, both metabolomics and phosphoproteomics were applied to identify the altered metabolites and phosphorylated proteins in liver of young (the WTY group) and naturally aged (the WTA group) mice, to find novel biomarkers and pathways, and uncover the biological mechanism...
November 2023: Heliyon
https://read.qxmd.com/read/37897763/measurement-of-ultra-high-energy-diffuse-gamma-ray-emission-of-the-galactic-plane-from-10%C3%A2-tev-to-1%C3%A2-pev-with-lhaaso-km2a
#10
JOURNAL ARTICLE
Zhen Cao, F Aharonian, Q An, Axikegu, Y X Bai, Y W Bao, D Bastieri, X J Bi, Y J Bi, J T Cai, Q Cao, W Y Cao, Zhe Cao, J Chang, J F Chang, A M Chen, E S Chen, Liang Chen, Lin Chen, Long Chen, M J Chen, M L Chen, Q H Chen, S H Chen, S Z Chen, T L Chen, Y Chen, N Cheng, Y D Cheng, M Y Cui, S W Cui, X H Cui, Y D Cui, B Z Dai, H L Dai, Z G Dai, Danzengluobu, D Della Volpe, X Q Dong, K K Duan, J H Fan, Y Z Fan, J Fang, K Fang, C F Feng, L Feng, S H Feng, X T Feng, Y L Feng, S Gabici, B Gao, C D Gao, L Q Gao, Q Gao, W Gao, W K Gao, M M Ge, L S Geng, G Giacinti, G H Gong, Q B Gou, M H Gu, F L Guo, X L Guo, Y Q Guo, Y Y Guo, Y A Han, H H He, H N He, J Y He, X B He, Y He, M Heller, Y K Hor, B W Hou, C Hou, X Hou, H B Hu, Q Hu, S C Hu, D H Huang, T Q Huang, W J Huang, X T Huang, X Y Huang, Y Huang, Z C Huang, X L Ji, H Y Jia, K Jia, K Jiang, X W Jiang, Z J Jiang, M Jin, M M Kang, T Ke, D Kuleshov, K Kurinov, B B Li, Cheng Li, Cong Li, D Li, F Li, H B Li, H C Li, H Y Li, J Li, Jian Li, Jie Li, K Li, W L Li, W L Li, X R Li, Xin Li, Y Z Li, Zhe Li, Zhuo Li, E W Liang, Y F Liang, S J Lin, B Liu, C Liu, D Liu, H Liu, H D Liu, J Liu, J L Liu, J Y Liu, M Y Liu, R Y Liu, S M Liu, W Liu, Y Liu, Y N Liu, R Lu, Q Luo, H K Lv, B Q Ma, L L Ma, X H Ma, J R Mao, Z Min, W Mitthumsiri, H J Mu, Y C Nan, A Neronov, Z W Ou, B Y Pang, P Pattarakijwanich, Z Y Pei, M Y Qi, Y Q Qi, B Q Qiao, J J Qin, D Ruffolo, A Sáiz, D Semikoz, C Y Shao, L Shao, O Shchegolev, X D Sheng, F W Shu, H C Song, Yu V Stenkin, V Stepanov, Y Su, Q N Sun, X N Sun, Z B Sun, P H T Tam, Q W Tang, Z B Tang, W W Tian, C Wang, C B Wang, G W Wang, H G Wang, H H Wang, J C Wang, K Wang, L P Wang, L Y Wang, P H Wang, R Wang, W Wang, X G Wang, X Y Wang, Y Wang, Y D Wang, Y J Wang, Z H Wang, Z X Wang, Zhen Wang, Zheng Wang, D M Wei, J J Wei, Y J Wei, T Wen, C Y Wu, H R Wu, S Wu, X F Wu, Y S Wu, S Q Xi, J Xia, J J Xia, G M Xiang, D X Xiao, G Xiao, G G Xin, Y L Xin, Y Xing, Z Xiong, D L Xu, R F Xu, R X Xu, W L Xu, L Xue, D H Yan, J Z Yan, T Yan, C W Yang, F Yang, F F Yang, H W Yang, J Y Yang, L L Yang, M J Yang, R Z Yang, S B Yang, Y H Yao, Z G Yao, Y M Ye, L Q Yin, N Yin, X H You, Z Y You, Y H Yu, Q Yuan, H Yue, H D Zeng, T X Zeng, W Zeng, M Zha, B B Zhang, F Zhang, H M Zhang, H Y Zhang, J L Zhang, L X Zhang, Li Zhang, P F Zhang, P P Zhang, R Zhang, S B Zhang, S R Zhang, S S Zhang, X Zhang, X P Zhang, Y F Zhang, Yi Zhang, Yong Zhang, B Zhao, J Zhao, L Zhao, L Z Zhao, S P Zhao, F Zheng, B Zhou, H Zhou, J N Zhou, M Zhou, P Zhou, R Zhou, X X Zhou, C G Zhu, F R Zhu, H Zhu, K J Zhu, X Zuo
The diffuse Galactic γ-ray emission, mainly produced via interactions between cosmic rays and the interstellar medium and/or radiation field, is a very important probe of the distribution, propagation, and interaction of cosmic rays in the Milky Way. In this Letter, we report the measurements of diffuse γ rays from the Galactic plane between 10 TeV and 1 PeV energies, with the square kilometer array of the Large High Altitude Air Shower Observatory (LHAASO). Diffuse emissions from the inner (15°<l<125°, |b|<5°) and outer (125°<l<235°, |b|<5°) Galactic plane are detected with 29...
October 13, 2023: Physical Review Letters
https://read.qxmd.com/read/37863886/establishment-of-a-novel-indicator-of-pyroptosis-regulated-gene-transcription-level-and-its-application-in-pan-cancer
#11
JOURNAL ARTICLE
Jin-Zhou Xu, Qi-Dong Xia, Jian-Xuan Sun, Chen-Qian Liu, Jun-Lin Lu, Meng-Yao Xu, Ye An, Yang Xun, Zheng Liu, Jia Hu, Cong Li, Shao-Gang Wang
Pyroptosis is a type of programmed cell death and plays a dual role in distinct cancers. It is elusive to evaluate the activation level of pyroptosis and to appraise the involvement of pyroptosis in the occurrence and development of diverse tumors. Accordingly, we herein established an indicator to evaluate pyroptosis related gene transcription levels based on the expression level of genes involved in pyroptosis and tried to elaborated on the association between pyroptosis and tumors across diverse tumor types...
October 20, 2023: Scientific Reports
https://read.qxmd.com/read/37395342/the-epigenetic-modifier-lysine-methyltransferase-2c-is-frequently-mutated-in-gastric-remnant-carcinoma
#12
JOURNAL ARTICLE
Bo Sun, Haojie Chen, Jiawen Lao, Cong Tan, Yue Zhang, Zhen Shao, Dazhi Xu
Gastric remnant carcinoma (GRC), which occurs in the stomach after partial gastrectomy, is a rare and aggressive form of gastric adenocarcinoma (GAC). Comprehensive profiling of genomic mutations in GRC could provide the basis for elucidating the origin and characteristics of this cancer. Herein, whole-exome sequencing (WES) was performed on 36 matched tumor-normal samples from patients with GRC and identified recurrent mutations in epigenetic modifiers, notably KMT2C, ARID1A, NSD1, and KMT2D, in 61.11% of cases...
July 3, 2023: Journal of Pathology. Clinical Research
https://read.qxmd.com/read/37289911/a-tera-electron-volt-afterglow-from-a-narrow-jet-in-an-extremely-bright-gamma-ray-burst
#13
JOURNAL ARTICLE
Zhen Cao, F Aharonian, Q An, Axikegu, L X Bai, Y X Bai, Y W Bao, D Bastieri, X J Bi, Y J Bi, J T Cai, Q Cao, W Y Cao, Zhe Cao, J Chang, J F Chang, E S Chen, Liang Chen, Lin Chen, Long Chen, M J Chen, M L Chen, Q H Chen, S H Chen, S Z Chen, T L Chen, Y Chen, H L Cheng, N Cheng, Y D Cheng, S W Cui, X H Cui, Y D Cui, B Z Dai, H L Dai, Z G Dai, Danzengluobu, D Della Volpe, X Q Dong, K K Duan, J H Fan, Y Z Fan, J Fang, K Fang, C F Feng, L Feng, S H Feng, X T Feng, Y L Feng, B Gao, C D Gao, L Q Gao, Q Gao, W Gao, W K Gao, M M Ge, L S Geng, G H Gong, Q B Gou, M H Gu, F L Guo, X L Guo, Y Q Guo, Y Y Guo, Y A Han, H H He, H N He, J Y He, X B He, Y He, M Heller, Y K Hor, B W Hou, C Hou, X Hou, H B Hu, Q Hu, S C Hu, D H Huang, T Q Huang, W J Huang, X T Huang, X Y Huang, Y Huang, Z C Huang, X L Ji, H Y Jia, K Jia, K Jiang, X W Jiang, Z J Jiang, M Jin, M M Kang, T Ke, D Kuleshov, K Kurinov, B B Li, Cheng Li, Cong Li, D Li, F Li, H B Li, H C Li, H Y Li, J Li, Jian Li, Jie Li, K Li, W L Li, W L Li, X R Li, Xin Li, Y Z Li, Zhe Li, Zhuo Li, E W Liang, Y F Liang, S J Lin, B Liu, C Liu, D Liu, H Liu, H D Liu, J Liu, J L Liu, J L Liu, J S Liu, J Y Liu, M Y Liu, R Y Liu, S M Liu, W Liu, Y Liu, Y N Liu, W J Long, R Lu, Q Luo, H K Lv, B Q Ma, L L Ma, X H Ma, J R Mao, Z Min, W Mitthumsiri, Y C Nan, Z W Ou, B Y Pang, P Pattarakijwanich, Z Y Pei, M Y Qi, Y Q Qi, B Q Qiao, J J Qin, D Ruffolo, A Sáiz, C Y Shao, L Shao, O Shchegolev, X D Sheng, H C Song, Y V Stenkin, V Stepanov, Y Su, Q N Sun, X N Sun, Z B Sun, P H T Tam, Z B Tang, W W Tian, C Wang, C B Wang, G W Wang, H G Wang, H H Wang, J C Wang, J S Wang, K Wang, L P Wang, L Y Wang, P H Wang, R Wang, W Wang, X G Wang, X Y Wang, Y Wang, Y D Wang, Y J Wang, Z H Wang, Z X Wang, Zhen Wang, Zheng Wang, D M Wei, J J Wei, Y J Wei, T Wen, C Y Wu, H R Wu, S Wu, X F Wu, Y S Wu, S Q Xi, J Xia, J J Xia, G M Xiang, D X Xiao, G Xiao, G G Xin, Y L Xin, Y Xing, Z Xiong, D L Xu, R F Xu, R X Xu, L Xue, D H Yan, J Z Yan, T Yan, C W Yang, F Yang, F F Yang, H W Yang, J Y Yang, L L Yang, M J Yang, R Z Yang, S B Yang, Y H Yao, Z G Yao, Y M Ye, L Q Yin, N Yin, X H You, Z Y You, Y H Yu, Q Yuan, H Yue, H D Zeng, T X Zeng, W Zeng, Z K Zeng, M Zha, B Zhang, B B Zhang, F Zhang, H M Zhang, H Y Zhang, J L Zhang, L X Zhang, L Zhang, P F Zhang, P P Zhang, R Zhang, S B Zhang, S R Zhang, S S Zhang, X Zhang, X P Zhang, Y F Zhang, Y Zhang, Yong Zhang, B Zhao, J Zhao, L Zhao, L Z Zhao, S P Zhao, F Zheng, J H Zheng, B Zhou, H Zhou, J N Zhou, P Zhou, R Zhou, X X Zhou, C G Zhu, F R Zhu, H Zhu, K J Zhu, X Zuo
Some gamma-ray bursts (GRBs) have a tera-electron volt (TeV) afterglow, but the early onset of this has not been observed. We report observations with the Large High Altitude Air Shower Observatory of the bright GRB 221009A, which serendipitously occurred within the instrument field of view. More than 64,000 photons >0.2 TeV were detected within the first 3000 seconds. The TeV flux began several minutes after the GRB trigger, then rose to a peak about 10 seconds later. This was followed by a decay phase, which became more rapid ~650 seconds after the peak...
June 8, 2023: Science
https://read.qxmd.com/read/37269088/pregnane-x-receptor-pxr-deficiency-protects-against-spinal-cord-injury-by-activating-nrf2-ho-1-pathway
#14
JOURNAL ARTICLE
Li-Na Xuan, Zhen-Xin Hu, Zhen-Fu Jiang, Cong Zhang, Xiao-Wan Sun, Wen-Hua Ming, Hui-Tao Liu, Rong-Fang Qiao, Lin-Jie Shen, Shao-Bo Liu, Guan-Yu Wang, Lin Wen, Zhi-Lin Luan, Jian Yin
INTRODUCTION: As a devastating neurological disease, spinal cord injury (SCI) results in severe tissue loss and neurological dysfunction. Pregnane X receptor (PXR) is a ligand-activated nuclear receptor with a major regulatory role in xenobiotic and endobiotic metabolism and recently has been implicated in the central nervous system. In the present study, we aimed to investigate the role and mechanism of PXR in SCI. METHODS: The clip-compressive SCI model was performed in male wild-type C57BL/6 (PXR+/+ ) and PXR-knockout (PXR-/- ) mice...
June 2, 2023: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/37096751/what-is-the-appropriate-genetic-testing-criteria-for-breast-cancer-in-the-chinese-population-analysis-of-genetic-and-clinical-features-from-a-single-cancer-center-database
#15
JOURNAL ARTICLE
Mengqian Ni, Fang Wang, Anli Yang, Qiong Shao, Cong Xue, Wen Xia, Fei Xu, Xi Lin, Jiajia Huang, Xiwen Bi, Ruoxi Hong, Meiting Chen, Qiufan Zheng, Kuikui Jiang, Xinhua Xie, Jun Tang, Xi Wang, Zhongyu Yuan, Shusen Wang, Yanxia Shi, Xin An
BACKGROUND: Genetic testing plays an important role in guiding screening, diagnosis, and precision treatment of breast cancer (BC). However, the appropriate genetic testing criteria remain controversial. The current study aims to facilitate the development of suitable strategies by analyzing the germline mutational profiles and clinicopathological features of large-scale Chinese BC patients. METHODS: BC patients who had undergone genetic testing at the Sun Yat-sen University Cancer Center (SYSUCC) from September 2014 to March 2022 were retrospectively reviewed...
April 25, 2023: Cancer Medicine
https://read.qxmd.com/read/37035135/integrated-bioinformatic-analysis-and-cell-line-experiments-reveal-the-significant-role-of-the-novel-immune-checkpoint-tigit-in-kidney-renal-clear-cell-carcinoma
#16
JOURNAL ARTICLE
Qi-Dong Xia, Bo Li, Jian-Xuan Sun, Chen-Qian Liu, Jin-Zhou Xu, Ye An, Meng-Yao Xu, Si-Han Zhang, Xing-Yu Zhong, Na Zeng, Si-Yang Ma, Hao-Dong He, Yu-Cong Zhang, Wei Guan, Heng Li, Shao-Gang Wang
BACKGROUND: T cell immunoglobulin and ITIM domain (TIGIT) is a widely concerned immune checkpoint, which plays an essential role in immunosuppression and immune evasion. However, the role of TIGIT in normal organ tissues and renal clear cell carcinoma is unclear. We aim to identify the critical role of TIGIT in renal clear cell carcinoma and find potential targeted TIGIT drugs. MATERIALS AND METHODS: Data retrieved from the GTEX database and TCGA database was used to investigate the expression of TIGIT in normal whole-body tissues and abnormal pan-cancer, then the transcriptome atlas of patients with kidney renal clear cell carcinoma (KIRC) in the TCGA database were applied to distinguish the TIGIT related features, including differential expression status, prognostic value, immune infiltration, co-expression, and drug response of sunitinib an anti-PD1/CTLA4 immunotherapy in KIRC...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37010067/acid-modulated-construction-of-cyclopenta-b-indole-and-cyclohepta-b-indole-via-unprecedented-c3-c2-carbocation-rearrangement
#17
JOURNAL ARTICLE
Shao-Cong Zhan, Jing Sun, Qiu Sun, Ying Han, Chao-Guo Yan
p -TsOH-catalyzed cycloaddition of various 3-vinylindoles and (indol-2-yl)diphenylmethanols in acetonitrile gave the functionalized cyclopenta[ b ]indoles in good yields and with high diastereoselectivity via [3 + 2] cycloaddition reaction. More importantly, FeCl3 -catalyzed annulation reaction afforded unexpected functionalized cyclohepta[1,2- b :4,5- b ']diindoles in satisfactory yields, in which a formal [4 + 3] cycloaddition and an unprecedented C3/C2 carbocation rearrangement were first confirmed by the determination of single-crystal structure...
April 3, 2023: Journal of Organic Chemistry
https://read.qxmd.com/read/36873738/circulating-the-hla-dr-t-cell-ratio-is-a-prognostic-factor-for-recurrence-of-patients-with-hepatocellular-carcinoma-after-curative-surgery
#18
JOURNAL ARTICLE
Rui-Qian Gao, Jing-Han Sun, Yong-Hui Ma, Yu-Wei Xie, Guan-Ming Shao, Cong Wang, Bin Tan, Kui Liu, Kun Li, Na Li, Wei-Yu Hu, Jingyu Cao
BACKGROUND: HLA-DR+ T cell, accounting for 1.2%-5.8% of peripheral lymphocyte, is a type of activated T lymphocyte. This retrospective study aimed to evaluate the prognostic value of HLA-DR+ T cell for progression-free survival (PFS) and overall survival (OS) in hepatocellular carcinoma (HCC) patients after curative surgery. Patients and Methods . Clinicopathological data of 192 patients who underwent curative resection for hepatocellular carcinoma in the affiliated hospital of Qingdao University between January 2013 and December 2021 were collected and analyzed...
2023: Journal of Oncology
https://read.qxmd.com/read/36870360/neoadjuvant-pd-1-blockade-with-sintilimab-in-mismatch-repair-deficient-locally-advanced-rectal-cancer-an-open-label-single-centre-phase-2-study
#19
JOURNAL ARTICLE
Gong Chen, Ying Jin, Wen-Long Guan, Rong-Xin Zhang, Wei-Wei Xiao, Pei-Qiang Cai, Min Liu, Jun-Zhong Lin, Fu-Long Wang, Cong Li, Ting-Ting Quan, Shao-Yan Xi, Hui-Zhong Zhang, Zhi-Zhong Pan, Feng Wang, Rui-Hua Xu
BACKGROUND: The current standard treatment for locally advanced rectal cancer is neoadjuvant chemoradiotherapy followed by radical surgery, but this approach can lead to multiple complications. We aimed to investigate the clinical activity and safety of neoadjuvant therapy with sintilimab, a single-agent PD-1 antibody, in patients with mismatch-repair deficient locally advanced rectal cancer. METHODS: This open-label, single-arm, phase 2 study was done at the Sun Yat-sen University Cancer Center, Guangzhou, China...
May 2023: Lancet. Gastroenterology & Hepatology
https://read.qxmd.com/read/36626227/ubc9-deficiency-enhances-immunostimulatory-macrophage-activation-and-subsequent-antitumor-t-cell-response-in-prostate-cancer
#20
JOURNAL ARTICLE
Jun Xiao, Fei Sun, Ya-Nan Wang, Bo Liu, Peng Zhou, Fa-Xi Wang, Hai-Feng Zhou, Yue Ge, Tian-Tian Yue, Jia-Hui Luo, Chun-Liang Yang, Shan-Jie Rong, Ze-Zhong Xiong, Sheng Ma, Qi Zhang, Yang Xun, Chun-Guang Yang, Yang Luan, Shao-Gang Wang, Cong-Yi Wang, Zhi-Hua Wang
The role of tumor-associated macrophages (TAMs) along with the regulatory mechanisms underlying distinct macrophage activation states remain poorly understood in prostate cancer (PCa). Herein, we reported that PCa growth in macrophage-specific Ubc9 deficient mice is substantially suppressed compared to their wild-type littermates, an effect partially ascribed to the augmented CD8+ T cell response. Biochemical and molecular analyses revealed that the signal transducer and activator of transcription 4 (STAT4) is a crucial UBC9-mediated SUMOylation target, with lysine residue 350 (K350) as the major modification site...
January 10, 2023: Journal of Clinical Investigation
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