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Zheng-gang Liu

Ling Mo, Jing Zheng, Ting Wang, Yun-Gang Shi, Biao-Juan Chen, Bin Liu, Yan-Hua Ma, Min Li, Li Zhuo, She-Jun Chen
Emerging and legacy hydrophobic pollutants, including halogenated flame retardants (HFRs), organophosphorus FRs (OPFRs), polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCPs), as well as polycyclic aromatic hydrocarbons (PAHs) were determined in coastal sediments of Hainan Island, southern China, where little information is known about their contamination. The HFRs were dominated by decabrominated diphenyl ethers (median = 1.32 ng/g) and novel decabromodiphenyl ethane (1.87 ng/g). HFR and PAH concentrations had similar spatial distributions, with higher levels in the river and near the estuary...
October 5, 2018: Chemosphere
Ying Liu, Jing Zheng, Hong Ping Zhang, Xin Zhang, Lei Wang, Lisa Wood, Gang Wang
PURPOSE: Obesity is associated with metabolic dysregulation, but the underlying metabolic signatures involving clinical and inflammatory profiles of obese asthma are largely unexplored. We aimed at identifying the metabolic signatures of obese asthma. METHODS: Eligible subjects with obese (n = 11) and lean (n = 22) asthma underwent body composition and clinical assessment, sputum induction, and blood sampling. Sputum supernatant was assessed for interleukin (IL)-1β, -4, -5, -6, -13, and tumor necrosis factor (TNF)-α, and serum was detected for leptin, adiponectin and C-reactive protein...
November 2018: Allergy, Asthma & Immunology Research
Xiaoyu Chen, Zainen Qin, Jinmin Zhao, Xiaohui Yan, Jing Ye, En Ren, Junqing Wang, Xingchen Yang, Shujun Heng, Li Zheng, Gang Liu
Mesenchymal stem cells (MSCs) have potential uses for cartilage repair due to the potential of chondrogenic differentiation. However, developing effective approaches to regulate chondrogenesis in vivo remains a big challenging. To address the limitations, we propose the application of magnetic fields, which features excellent performance for tissue penetration, good biocompatibility even at high magnetic strength, and wireless remote control. To test this concept, a pulsed magnetic field (PMF) was used to enhance the chondrogenesis of SPIO-labeled MSCs in a rat model of cartilage defects...
December 1, 2018: Journal of Biomedical Nanotechnology
Jisen Zhang, Xingtan Zhang, Haibao Tang, Qing Zhang, Xiuting Hua, Xiaokai Ma, Fan Zhu, Tyler Jones, Xinguang Zhu, John Bowers, Ching Man Wai, Chunfang Zheng, Yan Shi, Shuai Chen, Xiuming Xu, Jingjing Yue, David R Nelson, Lixian Huang, Zhen Li, Huimin Xu, Dong Zhou, Yongjun Wang, Weichang Hu, Jishan Lin, Youjin Deng, Neha Pandey, Melina Mancini, Dessireé Zerpa, Julie K Nguyen, Liming Wang, Liang Yu, Yinghui Xin, Liangfa Ge, Jie Arro, Jennifer O Han, Setu Chakrabarty, Marija Pushko, Wenping Zhang, Yanhong Ma, Panpan Ma, Mingju Lv, Faming Chen, Guangyong Zheng, Jingsheng Xu, Zhenhui Yang, Fang Deng, Xuequn Chen, Zhenyang Liao, Xunxiao Zhang, Zhicong Lin, Hai Lin, Hansong Yan, Zheng Kuang, Weimin Zhong, Pingping Liang, Guofeng Wang, Yuan Yuan, Jiaxian Shi, Jinxiang Hou, Jingxian Lin, Jingjing Jin, Peijian Cao, Qiaochu Shen, Qing Jiang, Ping Zhou, Yaying Ma, Xiaodan Zhang, Rongrong Xu, Juan Liu, Yongmei Zhou, Haifeng Jia, Qing Ma, Rui Qi, Zhiliang Zhang, Jingping Fang, Hongkun Fang, Jinjin Song, Mengjuan Wang, Guangrui Dong, Gang Wang, Zheng Chen, Teng Ma, Hong Liu, Singha R Dhungana, Sarah E Huss, Xiping Yang, Anupma Sharma, Jhon H Trujillo, Maria C Martinez, Matthew Hudson, John J Riascos, Mary Schuler, Li-Qing Chen, David M Braun, Lei Li, Qingyi Yu, Jianping Wang, Kai Wang, Michael C Schatz, David Heckerman, Marie-Anne Van Sluys, Glaucia Mendes Souza, Paul H Moore, David Sankoff, Robert VanBuren, Andrew H Paterson, Chifumi Nagai, Ray Ming
Modern sugarcanes are polyploid interspecific hybrids, combining high sugar content from Saccharum officinarum with hardiness, disease resistance and ratooning of Saccharum spontaneum. Sequencing of a haploid S. spontaneum, AP85-441, facilitated the assembly of 32 pseudo-chromosomes comprising 8 homologous groups of 4 members each, bearing 35,525 genes with alleles defined. The reduction of basic chromosome number from 10 to 8 in S. spontaneum was caused by fissions of 2 ancestral chromosomes followed by translocations to 4 chromosomes...
October 8, 2018: Nature Genetics
Wu Ding, Zhiwei Gu, Dagang Song, Jiansheng Liu, Gang Zheng, Chuanjian Tu
To develop and validate the prognosis model of hypertensive intracerebral hemorrhage based on admission characteristics, which would be applied to predict the 3-month outcome.For developing the prognosis models, we studied data from 325 patients with retrospectively consecutive hypertensive intracerebral hemorrhage admitted between 2012 and 2016. The predictive value of admission characteristics was tested in logistic regression models, presenting 3-month outcome as the primary outcome. The performance of the models was tested by discrimination and calibration...
September 2018: Medicine (Baltimore)
Wenzhen Yang, Jing Zheng, Ruihao Li, Haijun Ren, Boru Hou, Zhiyong Zhao, Dengfeng Wang, Gang Wang, Jixing Liu, Guizhong Yan, Dong Wang, Xinding Zhang
RATIONALE: MM is a malignant tumor originating from the plasma cells of the bone marrow. Central nervous system myelomatosis is very rare and may be a complication of MM. PATIENT CONCERNS: A 60-year-old man presented with a slowly growing soft mass at his right frontal scalp after a mild head injury 6 months ago. DIAGNOSES: Neuroradiological examinations revealed a solid intracranial-extracranial mass with an osteolytic lesion in the skull...
September 2018: Medicine (Baltimore)
Ya-Jun Wang, Li-Yuan Zheng, Zi-Fan Wang, Rui Song, Li Yang, Yue-Hang Geng, Fang Mei, Yun-Tao Xie, Lan Chen, Dong-Ge Liu, Xiang-Hong Li, Ying-Li Sun, Xin-Xia Tian, Wei-Gang Fang
Extensive evidence suggests that the genetic etiologies of breast cancer (BC) and ovarian cancer (OC) show a certain degree of similarity. This study aimed to find out whether the single nucleotide polymorphisms (SNPs) of genes SNAI1 and TWIST1 may affect BC and OC susceptibility. A total of 7 tagging‑SNPs (tSNPs) were directly genotyped in 1,161 BC cases, 286 OC cases and 1,273 cancer‑free controls among Chinese Han women. Twenty‑eight variants in these 2 genes were genotyped by 'in silico' genotype imputation...
September 21, 2018: Oncology Reports
Jing Guo, Jing Hao Ban, Gang Li, Xing Wang, Xi Ping Feng, Bao Jun Tai, De Yu Hu, Huan Cai Lin, Bo Wang, Yan Si, Chun Xiao Wang, Wen Sheng Rong, Wei Jian Wang, Shu Guo Zheng, Xue Nan Liu, Sheng Chao Wang
OBJECTIVE: To investigate the status of tooth loss and denture restoration in Chinese adults, analyse the changing trend and provide fundamental data for oral health policy. METHODS: According to the protocol of the 4th National Oral Health Survey, a multistage stratified random cluster-sampling method was used to enrol adult subjects aged 35 to 44, 55 to 64 and 65 to 74 years in all 31 provinces, municipalities and autonomous regions of the mainland of China. The status of tooth loss and denture restoration was investigated...
2018: Chinese Journal of Dental Research
Hua-Wei Liu, Dai-Xu Wei, Jiu-Zheng Deng, Jian-Jin Zhu, Kai Xu, Wen-Hao Hu, Song-Hua Xiao, Yong-Gang Zhou
To resolve the problems of bacterial infections and the low efficiency of osteogenesis of implanted titanium alloys in clinical dental and bone therapy, we developed a bifunctional titanium alloy (Ti) with a nano-hydroxyapatite (HA) coating (HBD + BMP/HA-Ti), which enables the sustained release of the natural antimicrobial peptide human β-defensin 3 (HBD-3) and bone morphogenetic protein-2 (BMP-2). Due to the poriferous nano-sized structure of the HA coating with a 20-30 μm thickness, the HBD + BMP/HA-Ti material had a high encapsulation efficiency (>74%) and exhibited synchronized slow release of HBD-3 and BMP-2...
September 27, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Jun-Lin Liu, Yong-Gang Fan, Zheng-Sheng Yang, Zhan-You Wang, Chuang Guo
As people age, iron deposits in different areas of the brain may impair normal cognitive function and behavior. Abnormal iron metabolism generates hydroxyl radicals through the Fenton reaction, triggers oxidative stress reactions, damages cell lipids, protein and DNA structure and function, and ultimately leads to cell death. There is an imbalance in iron homeostasis in Alzheimer's disease (AD). Excessive iron contributes to the deposition of β-amyloid and the formation of neurofibrillary tangles, which in turn, promotes the development of AD...
2018: Frontiers in Neuroscience
Fengyuan Wang, Zhicai Zuo, Kejie Chen, Jing Fang, Hengmin Cui, Gang Shu, Yi Zhou, Zhengli Chen, Chao Huang, Wentao Liu
Obesity has been identified as a risk factor for adverse outcomes of various diseases. However, information regarding the difference between the response of obese and normal subjects to pulmonary inflammation is limited. Mice were fed with the control or high-fat diet to establish the lean and diet-induced obese (DIO) mice. Escherichia coli was intranasally instilled to reproduce non-fatal acute pneumonia model. After infection, serum samples and lung tissues were obtained at 0, 12, 24, and 72 h. DIO mice exhibited increased serum triglyceride (TG) and total cholesterol (TC) contents as well as pulmonary resistin, IL-6, and leptin levels compared with lean mice...
September 24, 2018: Scientific Reports
Bei-Lei Liu, Mian Cheng, Shan Hu, Shun Wang, Le Wang, Zheng-Qing Hu, Cong-Xin Huang, Hong Jiang, Gang Wu
Background: Shensong Yangxin Capsule (SSYX), traditional Chinese medicine, has been used to treat arrhythmias, angina, cardiac remodeling, cardiac fibrosis, and so on, but its effect on cardiac energy metabolism is still not clear. The objective of this study was to investigate the effects of SSYX on myocardium energy metabolism in angiotensin (Ang) II-induced cardiac hypertrophy. Methods: We used 2 μl (10-6 mol/L) AngII to treat neonatal rat cardiomyocytes (NRCMs) for 48 h...
October 5, 2018: Chinese Medical Journal
Rui Zhang, Min Ma, Xia-Hui Lin, Hua-Hua Liu, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren, Rong-Xin Chen
BACKGROUND: Accelerated malignant behaviors induced by insufficient thermal ablation have been increasingly reported, however, the exact mechanisms are still unclear. Here, we investigated the importance of the extracellular matrix (ECM) in modulating the progression of residual hepatocellular carcinoma (HCC) after heat treatment. METHODS: Heat-exposed residual HCC cells were cultured in different ECM gels. We used basement membrane gel (Matrigel) to simulate the normal microenvironment and collagen I to model the pathological stromal ECM...
September 18, 2018: BMC Cancer
Bai-Sui Feng, Yong-Jin Wu, Xian-Hai Zeng, Dian Yu, Zhi-Qiang Liu, Cai-Jie Zhou, Zhi-Gang Liu, Peng-Yuan Zheng, Ping-Chang Yang
The immune dysregulation plays an important role in the pathogenesis of ulcerative colitis (UC). Bcl2 like protein-12 (Bcl2L12) and mast cells are involved in immune dysregulation of UC. This study aims to elucidate the role of Bcl2L12 in the contribution to the pathogenesis of T helper (Th)2-biased inflammation in UC patients. The results showed that Bcl2L12 was expressed by peripheral CD4+ T cells that was associated with Th2 polarization in UC patients. Bcl2L12 mediated the protease-activated receptor-2 (PAR2)-induced IL-4 expression in CD4+ cells...
September 11, 2018: Archives of Biochemistry and Biophysics
Moyang Liu, Zhaotang Ma, Tianrun Zheng, Jing Wang, Li Huang, Wenjun Sun, Yanjun Zhang, Weiqiong Jin, Junyi Zhan, Yuntao Cai, Yujia Tang, Qi Wu, Zizhong Tang, Tongliang Bu, Chenglei Li, Hui Chen, Gang Zhao
Tartary buckwheat is a type of cultivated medicinal and edible crop with good economic and nutritional value. Knowledge of the final fruit size of buckwheat is critical to its yield increase. In this study, the fruit development of two species of Tartary buckwheat in the Polygonaceae was analyzed. During fruit development, the size/weight, the contents of auxin (AUX)/abscisic acid (ABA), the number of cells, and the changes of embryo were measured and observed; and the two fruit materials were compared to determine the related mechanisms that affected fruit size and the potential factors that regulated the final fruit size...
September 13, 2018: International Journal of Molecular Sciences
Kai Li, Yong Zhang, Ling Wang, Yang-Yang Duanmu, Wei Tian, Hui Chen, Lu Yin, Jian Bo, Yang Wang, Wei Li, Li He, Wen-Hua Zhao, Shao-Qi Xu, Lin-Fen Zhao, Jun Zhou, Feng-Zhe Wang, Yu Liu, Lei Zhu, Yi-Zhong Chen, Xiao-Lin Zhang, Xiao-Guang Hao, Zhi-Wei Shi, Jun-Ying Wang, Ji-Man Shao, Zhi-Jian Chen, Ren-Sheng Lei, Gang Ning, Qian Zhao, Yong-Hong Jiang, Ya-Hong Zhi, Bao-Qing Li, Xiao Chen, Quan-Yong Xiang, Liang Wang, Yuan-Zheng Ma, Shi-Wei Liu, Xiao-Guang Cheng
The Prospective Urban Rural Epidemiology (PURE) China Action on Spine and Hip status (CASH) study focused on the prevalence of osteoporosis and spinal fracture in China. The aim of the PURE CASH study is to determine the prevalence of osteoporosis and spinal fracture, and explore the potential relationship between spinal fracture and bone mineral density (BMD). This study is a prospective large-scale population study with a community-based sampling and recruitment strategy. The aim is to determine the prevalence of osteoporosis and vertebral fracture in this population, to evaluate the association between vertebral fractures and BMD values, and to assess the prediction power of BMD for incident fractures...
August 2018: Quantitative Imaging in Medicine and Surgery
Zheng Wang, Li Wang, Xue Wu, Ya-Lei Pan, Pei Xie, Gang Pei, Yan-Ni Liang, Zhi-Shu Tang, Li Liu
Portulacae Oleracea L. (POL) is a traditional Chinese medicine and also an edible vegetable used to treat diarrhea in china for thousands years. Though the therapeutic effect has been proved in clinical trials, the concrete effective component and mechanisms remained elusive. Polysaccharide from POL has been extracted previously and the experiment suggested that POLP could diminish the weight loss and improve the health conditions of mice with DSS induced colitis. Hematoxylin & eosin staining revealed that POLP could improve the histopathological structure of the colon tissue...
2018: American Journal of Translational Research
Bai-Sui Feng, Yong-Jin Wu, Jing-Yi Hong, Xiao-Rui Geng, Jiang-Qi Liu, Zhi-Gang Liu, Peng-Yuan Zheng, Ping-Chang Yang
The skewed T helper (Th) 2 response plays a central role in the pathogenesis of allergic diseases, while its initiating factors remain elusive. Recent studies indicate that Bcl2 like protein-12 (Bcl2L12) is associated with the Th2-biased inflammation. This study is designed to test a hypothesis that Bcl2L12 plays a critical role in the initiation of allergic response. In this study, peripheral CD4+ T cells were isolated from food allergy (FA) patients and healthy subjects; A mouse FA model was developed to test the role of Bcl2L12 in induction of allergic response in the intestine...
September 5, 2018: Immunology Letters
Gui-Hua Liu, Jing Zhang, Gui-Hua Sun, Jia-Hui Pang, Yi-da Wang, Cong Fang, Min-Fang Zhang, Xiao Gao, Hong Chen, Xiao-Mei Kang, Ya-Lu Zheng, De-Juan Sun, Hai-Tao Zeng, Lu-Gang Zhao, Zhong-Yang Wang, Xiao-Yan Liang
Objective: To investigate the value of micro- dissection testicular sperm extraction (micro-TESE) in the treatment of non-obstructive azoospermia (NOA) in patients with the history of secondary testicular injury. METHODS: Totally, 121 NOA patients with the history of secondary testicular injury underwent micro-TESE in our hospital from September 2014 to December 2017. We analyzed the correlation of the sperm retrieval rate with the causes of testicular injury and compared the outcomes of the ICSI cycles with the sperm retrieved from the NOA males by micro-TESE (the micro-TESE group) and those with the sperm ejaculated from severe oligospermia patients (sperm concentration <1×10⁶/ml, the ejaculate group)...
August 2018: Zhonghua Nan Ke Xue, National Journal of Andrology
Zhihui Dong, Tianyue Pan, Yuan Fang, Zheng Wei, Shiyang Gu, Gang Fang, Yifan Liu, Yang Luo, Hao Liu, Tiejun Zhang, Meiyu Hu, Daqiao Guo, Xin Xu, Bin Chen, Junhao Jiang, Jue Yang, Zhenyu Shi, Ting Zhu, Yun Shi, Peng Liu, Weiguo Fu
BACKGROUND: Peripheral blood mononuclear cells (PBMNCs) and purified CD34+ cells (PCCs) are increasingly being used at treating no-option critical limb ischaemia (NO-CLI). We aimed to compare the efficacies and uncover the advantages associated with each treatment approach. METHODS: A randomised single-blinded non-inferiority trial (Number: NCT 02089828) was performed. NO-CLI patients were 1:1 randomised to the PBMNCs and PCCs groups, and compared in relation to safety and efficacy outcomes...
September 2018: EBioMedicine
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