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Zheng-gang Liu

Xiaolei Shi, Kun Zheng, Min Hong, Weidi Liu, Raza Moshwan, Yuan Wang, Xianlin Qu, Zhi-Gang Chen, Jin Zou
In this study, we, for the first time, report a high Cu solubility of 11.8% in single crystal SnSe microbelts synthesized via a facile solvothermal route. The pellets sintered from these heavily Cu-doped microbelts show a high power factor of 5.57 μW cm-1 K-2 and low thermal conductivity of 0.32 W m-1 K-1 at 823 K, contributing to a high peak ZT of ∼1.41. Through a combination of detailed structural and chemical characterizations, we found that with increasing the Cu doping level, the morphology of the synthesized Sn1- x Cu x Se ( x is from 0 to 0...
October 7, 2018: Chemical Science
Xin-Bao Han, Xing-Yan Tang, Yue Lin, Eduardo Gracia-Espino, Sang-Gui Liu, Hai-Wei Liang, Guang-Zhi Hu, Xin-Jing Zhao, Hong-Gang Liao, Yuan-Zhi Tan, Thomas Wagberg, Su-Yuan Xie, Lan-Sun Zheng
The oxygen evolution reaction is a crucial step in water electrolysis to develop clean and renewable energy. Although noble metal-based catalysts have demonstrated high activity for oxygen evolution reaction, their application have been limited by their high costs and low availability. Here we report the use of a molecule-to-cluster strategy to prepare ultra-small trimetallic clusters by using polyoxometalate molecule as precursors. The ultrafine (0.8 nm) transition metal clusters with controllable chemical composition are obtained...
December 12, 2018: Journal of the American Chemical Society
Yangong Liu, Tomohiro Iwano, Fangfang Ma, Pu Wang, Yan Wang, Mingqi Zheng, Gang Liu, Katsushige Ono
T-type calcium (Ca2+ ) channels play important physiological functions in excitable cells including cardiomyocyte. Phosphatidylinositol-4,5-bisphosphate (PIP2 ) has recently been reported to modulate various ion channels' function. However the actions of PIP2 on the T-type Ca2+ channel remain unclear. To elucidate possible effects of PIP2 on the T-type Ca2+ channel, we applied patch clamp method to investigate recombinant CaV 3.1- and CaV 3.2-T-type Ca2+ channels expressed in mammalian cell lines with PIP2 in acute- and long-term potentiation...
December 1, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
Qun Liu, Jianhui Chen, Baolan Wang, Yulong Zheng, Yufeng Wan, Yi Wang, Liyang Zhou, Shu Liu, Gang Li, Yi Yan
Lung cancer is the leading cause of cancer-related deaths worldwide. Epithelial-mesenchymal transition (EMT) is a major event that drives cancer progression. Here we aim to investigate the role of microRNA, miR-145, in regulating EMT of the highly invasive non-small cell lung cancer (NSCLC). Quantitative real-time polymerase chain reaction analysis indicated that miR-145 was downregulated in cancer tissue compared with that in adjacent normal tissue. NSCLC cell lines, namely H1299, PC7, and SPCA-1, also demonstrated miR-145 downregulation, which is correlated well with their invasive ability, assessed by the Matrigel invasion assay...
December 7, 2018: Journal of Cellular Biochemistry
Zhao-Shan Liu, Hong Cai, Wen Xue, Miao Wang, Tian Xia, Wan-Jin Li, Jia-Qing Xing, Ming Zhao, Yi-Jiao Huang, Shuai Chen, Sheng-Ming Wu, Xinzheng Wang, Xin Liu, Xue Pang, Zi-Yu Zhang, Tingting Li, Jiang Dai, Fangting Dong, Qing Xia, Ai-Ling Li, Tao Zhou, Zheng-Gang Liu, Xue-Min Zhang, Tao Li
Cyclic GMP-AMP synthase (cGAS) is a key sensor responsible for cytosolic DNA detection. Here we report that GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is critical for DNA sensing and efficient activation of cGAS. G3BP1 enhanced DNA binding of cGAS by promoting the formation of large cGAS complexes. G3BP1 deficiency led to inefficient DNA binding by cGAS and inhibited cGAS-dependent interferon (IFN) production. The G3BP1 inhibitor epigallocatechin gallate (EGCG) disrupted existing G3BP1-cGAS complexes and inhibited DNA-triggered cGAS activation, thereby blocking DNA-induced IFN production both in vivo and in vitro...
January 2019: Nature Immunology
Gang Liu, Feinan Hu, Fenli Zheng, Qiong Zhang
Many erosion control techniques, such as stone pitching, concrete revetment, and geotextile covering, have been effective at protecting cut slopes along roads or railways. However, these methods are expensive and hard to operate for high stairstep cut-slopes. To investigate the efficiency of several easily implemented and low-cost techniques, five plots with different treatments were built on stairstep cut-slopes. The five treatments consisted of vegetation coverage on platforms, counter-slope on platforms, upslope drainage, a control check (CK), and a comprehensive treatment of the first three techniques...
November 27, 2018: Science of the Total Environment
Lei Wang, Michael Chopp, XueRong Lu, Alexandra Szalad, LongFei Jia, Xian Shuang Liu, Kuan-Han Wu, Mei Lu, Zheng Gang Zhang
Diabetes induces neurovascular dysfunction leading to peripheral neuropathy. MicroRNAs (miRNAs) affect many biological processes and the development of diabetic peripheral neuropathy. In the present study, we investigated whether thymosin-β4 (Tβ4) ameliorates diabetic peripheral neuropathy and whether miR-146a mediates the effect of Tβ4 on improved neurovascular function. Male Type II diabetic BKS.Cg-m+/+Leprdb /J (db/db) mice at age 20 weeks were treated with Tβ4 for 8 consecutive weeks, and db/db mice treated with saline were used as a control group...
November 27, 2018: Brain Research
Yunlei Zhang, Qianqian Ni, Chaoli Xu, Bing Wan, Yuanyuan Geng, Gang Zheng, Jun Tao, Zhenlu Yang, Ying Zhao, Jun Wen, Junjie Zhang, Shouju Wang, Yuxia Tang, Yanju Li, Qirui Zhang, Li Liu, Zhaogang Teng, Guangming Lu
Supersensitive magnetic resonance (MR) imaging requires contrast with extremely high r2 values. However, synthesized magnetic nanoparticles generally have a relatively low r2 relaxivity. Magnetosomes with high saturation magnetization and good biocompatibility have shown potential value as MR imaging contrast agents. Magnetosomes that target human epidermal growth factor receptor-2 (HER2) were prepared using genetic technology and low-frequency sonication. Anti-HER2 affibody of the ability to target HER2 was displayed on membrane surface of the magnetosomes through the anchor protein MamC, allowing the bacterial nanoparticles to target tumors overexpressing HER2...
November 29, 2018: ACS Applied Materials & Interfaces
Chong Shen, Tongmeng Jiang, Bo Zhu, Yiguan Le, Jianwei Liu, Zainen Qin, Haimin Chen, Gang Zhong, Li Zheng, Jinmin Zhao, Xingdong Zhang
In vitro expansion of mesenchymal stem cells (MSCs) has been implicated in loss of multipotency, leading to impaired chondrogenic potential and an eventual therapeutic effect, as reported in our previous study. However, the precise regulatory mechanism is still unclear. Here, we demonstrate that endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) were involved in transformation of MSCs induced by in vitro culture based on the comparative profiling of in vitro cultured bone marrow MSCs at passage 3 (P3 BMSCs) vs...
2018: Journal of Biological Engineering
Rui Liu, Hong-Gang Zheng, Wei-Dong Li, Bao-Jin Hua, Bo Yao, Xin Qi, Ying-Xia Pei, Yun Zhang
The aim of this paper was to observe the effect of Feiliuping Gao and its combination with different types of drugs intervention on the expression of PI3K/AKT/NF-κB in lung metastatic microenvironment, and to reveal the advantage of Chinese medicine intervention time on the key molecule in lung metastatic microenvironment. The mouse model of Lewis lung carcinoma was established, and lung tissues were collected at 14 days, 21 days and 28 days after the intervention of Feiliuping Gao, and the expressions of PI3K, AKT and NF-κB were detected by immunohistochemistry and Western blot...
October 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Fenglin Zhang, Jingjing Ye, Yingying Meng, Wei Ai, Han Su, Jisong Zheng, Fangfang Liu, Xiaotong Zhu, Lina Wang, Ping Gao, Gang Shu, Qingyan Jiang, Songbo Wang
BACKGROUND/AIMS: It has been implicated that calcium supplementation is involved in reducing body weight/fat and improving glucose homeostasis. However, the underlying mechanisms are still not fully understood. Here, we investigated the effects of calcium supplementation on adipogenesis and glucose homeostasis in porcine bone marrow mesenchymal stem cells (pBMSCs) and high fat diet (HFD)-fed mice and explored the involved signaling pathways. METHODS: In vitro, pBMSCs were treated with 4 mM extracellular calcium ([Ca2+]o) and/or 1 μM nifedipine, 0...
2018: Cellular Physiology and Biochemistry
Baoyan Fan, Xian Shuang Liu, Alexandra Szalad, Lei Wang, Ruilan Zhang, Michael Chopp, Zheng Gang Zhang
Cognition impairment and peripheral neuropathy (DPN) are two major complications of diabetes. The aim of the present study is to investigate the effect of sex differences on cognition and DPN in diabetic mice. Male and female BKS.Cg- m +/+ Leprdb/J (db/db) and db/m mice were used. At ages of 20 and 30 weeks, all animals were subjected to learning, memory and neurological function tests. Regional blood flow in footpad and sciatic nerves were measured using laser Doppler flowmetry. Our data showed that male db/db mice aged 20 weeks and 30 weeks spent significantly more time to locate the hidden platform in the correct quadrant and spent significantly less time exploring the cage with a new stranger mouse compared to aged-matched female db/db mice...
2018: Frontiers in Neuroscience
Jisen Zhang, Xingtan Zhang, Haibao Tang, Qing Zhang, Xiuting Hua, Xiaokai Ma, Fan Zhu, Tyler Jones, Xinguang Zhu, John Bowers, Ching Man Wai, Chunfang Zheng, Yan Shi, Shuai Chen, Xiuming Xu, Jingjing Yue, David R Nelson, Lixian Huang, Zhen Li, Huimin Xu, Dong Zhou, Yongjun Wang, Weichang Hu, Jishan Lin, Youjin Deng, Neha Pandey, Melina Mancini, Dessireé Zerpa, Julie K Nguyen, Liming Wang, Liang Yu, Yinghui Xin, Liangfa Ge, Jie Arro, Jennifer O Han, Setu Chakrabarty, Marija Pushko, Wenping Zhang, Yanhong Ma, Panpan Ma, Mingju Lv, Faming Chen, Guangyong Zheng, Jingsheng Xu, Zhenhui Yang, Fang Deng, Xuequn Chen, Zhenyang Liao, Xunxiao Zhang, Zhicong Lin, Hai Lin, Hansong Yan, Zheng Kuang, Weimin Zhong, Pingping Liang, Guofeng Wang, Yuan Yuan, Jiaxian Shi, Jinxiang Hou, Jingxian Lin, Jingjing Jin, Peijian Cao, Qiaochu Shen, Qing Jiang, Ping Zhou, Yaying Ma, Xiaodan Zhang, Rongrong Xu, Juan Liu, Yongmei Zhou, Haifeng Jia, Qing Ma, Rui Qi, Zhiliang Zhang, Jingping Fang, Hongkun Fang, Jinjin Song, Mengjuan Wang, Guangrui Dong, Gang Wang, Zheng Chen, Teng Ma, Hong Liu, Singha R Dhungana, Sarah E Huss, Xiping Yang, Anupma Sharma, Jhon H Trujillo, Maria C Martinez, Matthew Hudson, John J Riascos, Mary Schuler, Li-Qing Chen, David M Braun, Lei Li, Qingyi Yu, Jianping Wang, Kai Wang, Michael C Schatz, David Heckerman, Marie-Anne Van Sluys, Glaucia Mendes Souza, Paul H Moore, David Sankoff, Robert VanBuren, Andrew H Paterson, Chifumi Nagai, Ray Ming
In the version of this article originally published, the accession codes listed in the data availability section were incorrect and the section was incomplete. The text for this section should have read "The genome assembly and gene annotation have been deposited in the NCBI database under accession number QVOL00000000, BioProject number PRJNA483885 and BioSample number SAMN09753102. The data can also be downloaded from the following link: ...
November 13, 2018: Nature Genetics
Yue-Hang Geng, Zi-Fan Wang, Yu-Mian Jia, Li-Yuan Zheng, Lan Chen, Dong-Ge Liu, Xiang-Hong Li, Xin-Xia Tian, Wei-Gang Fang
The cadherin 1 ( CDH1 ) gene plays critical roles in the epithelial-mesenchymal transition process, potentially offering us a glimpse into the development of endometrial carcinoma (EC). The present study aimed to identify whether genetic variants in CDH1 affect EC susceptibility in Chinese Han women, using a strategy combining haplotype-tagging single nucleotide polymorphisms (htSNPs) association analysis with fine-scale mapping. A total of 9 htSNPs in CDH1 were genotyped among 516 cases and 706 age-matched cancer-free controls...
November 2018: Oncology Letters
Dafei Chai, Hongjian Shan, Gang Wang, Qing Zhang, Huizhong Li, Lin Fang, Jingyuan Song, Nianli Liu, Qian Zhang, Hong Yao, Junnian Zheng
Renal carcinoma presents a rapid progression in patients with high metastasis with no effective therapeutic strategy. In this study, we designed a folate grafted PEI600-CyD (H1) nanoparticle-mediated DNA vaccine containing an adjuvant of absent in melanoma 2 (AIM2) and a tumor-specific antigen of carbonic anhydrase IX (CAIX) for renal carcinoma therapy. Mice bearing subcutaneous human CAIX (hCAIX)-Renca tumor were intramuscularly immunized with H1-pAIM2/pCAIX, H1-pCAIX, H1-pAIM2, or Mock vaccine, respectively...
November 6, 2018: Molecular Cancer Therapeutics
Gang Yuan, Xiao Zhao, Yeru Liang, Lin Peng, Hanwu Dong, Yong Xiao, Chaofan Hu, Hang Hu, Yingliang Liu, Mingtao Zheng
As a new class of zero-dimensional carbon nanomaterials, carbon dots have triggered intensive research interest in various fields. However, the low surface area, hydrophilicity, and agglomeration characteristics limit their applications in energy storage fields. Herein, we demonstrate that nitrogen-doped carbon dots can be employed as efficient nanoenhancer to boost the electrochemical performance of three-dimensional graphene. The as-prepared materials exhibit an interconnected framework with abundant oxygen- and nitrogen-containing functional groups, which enable fast penetration and transport of electrolyte ions and provide more active sites and electric conductivity...
February 15, 2019: Journal of Colloid and Interface Science
Haipeng Liu, Haiping Zhang, Xiangyang Wu, Dapeng Ma, Juehui Wu, Lin Wang, Yan Jiang, Yiyan Fei, Chenggang Zhu, Rong Tan, Peter Jungblut, Gang Pei, Anca Dorhoi, Qiaoling Yan, Fan Zhang, Ruijuan Zheng, Siyu Liu, Haijiao Liang, Zhonghua Liu, Hua Yang, Jianxia Chen, Peng Wang, Tianqi Tang, Wenxia Peng, Zhangsen Hu, Zhu Xu, Xiaochen Huang, Jie Wang, Haohao Li, Yilong Zhou, Feng Liu, Dapeng Yan, Stefan H E Kaufmann, Chang Chen, Zhiyong Mao, Baoxue Ge
Accurate repair of DNA double-stranded breaks by homologous recombination preserves genome integrity and inhibits tumorigenesis. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that activates innate immunity by initiating the STING-IRF3-type I IFN signalling cascade1,2 . Recognition of ruptured micronuclei by cGAS links genome instability to the innate immune response3,4 , but the potential involvement of cGAS in DNA repair remains unknown. Here we demonstrate that cGAS inhibits homologous recombination in mouse and human models...
November 2018: Nature
Jian Zhou, Hui-Chuan Sun, Zheng Wang, Wen-Ming Cong, Jian-Hua Wang, Meng-Su Zeng, Jia-Mei Yang, Ping Bie, Lian-Xin Liu, Tian-Fu Wen, Guo-Hong Han, Mao-Qiang Wang, Rui-Bao Liu, Li-Gong Lu, Zheng-Gang Ren, Min-Shan Chen, Zhao-Chong Zeng, Ping Liang, Chang-Hong Liang, Min Chen, Fu-Hua Yan, Wen-Ping Wang, Yuan Ji, Wen-Wu Cheng, Chao-Liu Dai, Wei-Dong Jia, Ya-Ming Li, Ye-Xiong Li, Jun Liang, Tian-Shu Liu, Guo-Yue Lv, Yi-Lei Mao, Wei-Xin Ren, Hong-Cheng Shi, Wen-Tao Wang, Xiao-Ying Wang, Bao-Cai Xing, Jian-Ming Xu, Jian-Yong Yang, Ye-Fa Yang, Sheng-Long Ye, Zheng-Yu Yin, Bo-Heng Zhang, Shui-Jun Zhang, Wei-Ping Zhou, Ji-Ye Zhu, Rong Liu, Ying-Hong Shi, Yong-Sheng Xiao, Zhi Dai, Gao-Jun Teng, Jian-Qiang Cai, Wei-Lin Wang, Jia-Hong Dong, Qiang Li, Feng Shen, Shu-Kui Qin, Jia Fan
Background: Hepatocellular carcinoma (HCC) (about 85-90% of primary liver cancer) is particularly prevalent in China because of the high prevalence of chronic hepatitis B infection. HCC is the fourth most common malignancy and the third leading cause of tumor-related deaths in China. It poses a significant threat to the life and health of Chinese people. Summary: This guideline presents official recommendations of the National Health and Family Planning Commission of the People's Republic of China on the surveillance, diagnosis, staging, and treatment of HCC occurring in China...
September 2018: Liver Cancer
Ling Mo, Jing Zheng, Ting Wang, Yun-Gang Shi, Biao-Juan Chen, Bin Liu, Yan-Hua Ma, Min Li, Li Zhuo, She-Jun Chen
Emerging and legacy hydrophobic pollutants, including halogenated flame retardants (HFRs), organophosphorus FRs (OPFRs), polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCPs), as well as polycyclic aromatic hydrocarbons (PAHs) were determined in coastal sediments of Hainan Island, southern China, where little information is known about their contamination. The HFRs were dominated by decabrominated diphenyl ethers (median = 1.32 ng/g) and novel decabromodiphenyl ethane (1.87 ng/g). HFR and PAH concentrations had similar spatial distributions, with higher levels in the river and near the estuary...
January 2019: Chemosphere
Ying Liu, Jing Zheng, Hong Ping Zhang, Xin Zhang, Lei Wang, Lisa Wood, Gang Wang
PURPOSE: Obesity is associated with metabolic dysregulation, but the underlying metabolic signatures involving clinical and inflammatory profiles of obese asthma are largely unexplored. We aimed at identifying the metabolic signatures of obese asthma. METHODS: Eligible subjects with obese (n = 11) and lean (n = 22) asthma underwent body composition and clinical assessment, sputum induction, and blood sampling. Sputum supernatant was assessed for interleukin (IL)-1β, -4, -5, -6, -13, and tumor necrosis factor (TNF)-α, and serum was detected for leptin, adiponectin and C-reactive protein...
November 2018: Allergy, Asthma & Immunology Research
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