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https://www.readbyqxmd.com/read/29053535/histologic-status-of-squamous-cell-carcinoma-in-situ-after-diagnostic-biopsy-in-immunocompetent-and-immunosuppressed-patients
#1
Eduardo K Moioli, Clifford Hsieh, Angela Tisch, Diana Bolotin
BACKGROUND: The histologic status of squamous cell carcinoma in situ (SCC-IS) after diagnostic biopsy has not been well described or compared between immunocompetent and immunosuppressed patients. Expression of immunohistochemical (IHC) markers of aggressive SCC has not been compared between SCC-IS that clears or becomes invasive after biopsy. OBJECTIVE: To determine the histologic status of SCC-IS after diagnostic biopsy in these populations. METHODS: Retrospective analysis of 129 patients with SCC-IS treated with excision and 55 patients treated with Mohs surgery...
October 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29045075/immunocytochemistry-for-sox-11-and-tfe3-as-diagnostic-markers-for-solid-pseudopapillary-neoplasms-of-the-pancreas-in-fna-biopsies
#2
Wen-Chi Foo, Grant Harrison, Xuefeng Zhang
BACKGROUND: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare malignant tumors that can be sampled via endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Although diagnosing SPNs can be straightforward in cases with a classic morphology and a typical immunoprofile, challenges can occur with morphologic variants or limited specimens. Recently, 2 immunohistochemical stains, SRY-related high-mobility group box 11 (SOX-11) and transcription factor E3 (TFE3), have been demonstrated to be highly sensitive and specific for SPNs in pancreatic resection specimens...
October 16, 2017: Cancer
https://www.readbyqxmd.com/read/28981109/dexamethasone-mediates-pancreatic-cancer-progression-by-glucocorticoid-receptor-tgf%C3%AE-and-jnk-ap-1
#3
Li Liu, Ewa Aleksandrowicz, Frank Schönsiegel, Daniel Gröner, Nathalie Bauer, Clifford C Nwaeburu, Zhefu Zhao, Jury Gladkich, Torsten Hoppe-Tichy, Eitan Yefenof, Thilo Hackert, Oliver Strobel, Ingrid Herr
Glucocorticoids such as dexamethasone are widely co-prescribed with cytotoxic therapy because of their proapoptotic effects in lymphoid cancer, reduction of inflammation and edema and additional benefits. Concerns about glucocorticoid-induced therapy resistance, enhanced metastasis and reduced survival of patients are largely not considered. We analyzed dexamethasone-induced tumor progression in three established and one primary human pancreatic ductal adenocarcinoma (PDA) cell lines and in PDA tissue from patients and xenografts by FACS and western blot analysis, immunohistochemistry, MTT and wound assay, colony and spheroid formation, EMSA and in vivo tumor growth and metastasis of tumor xenografts on chicken eggs and mice...
October 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28977876/wogonoside-inhibits-il-1%C3%AE-induced-catabolism-and-hypertrophy-in-mouse-chondrocyte-and-ameliorates-murine-osteoarthritis
#4
Qian Tang, Gang Zheng, Zhenhua Feng, Minji Tong, Jianxiang Xu, Zhiyan Hu, Ping Shang, Yu Chen, Chenggui Wang, Yiting Lou, Deheng Chen, Di Zhang, Majid Nisar, Xiaolei Zhang, Huazi Xu, Haixiao Liu
The inflammatory environment is correlated with extracellular matrix (ECM) degradation and chondrocyte hypertrophy in the development of osteoarthritis (OA). Previous studies have reported the anti-inflammatory effects of wogonoside in several diseases. In the present study, we investigated the protective effects of wogonoside in relation to the development of OA and delineated the potential mechanism. In vitro, wogonoside decreased the production of pro-inflammatory cytokines like Nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6)...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976591/effect-of-mechanical-strain-on-the-pluripotency-of-murine-embryonic-stem-cells-seeded-in-a-collagen-i-scaffold
#5
Olesja Hazenbiller, Saghar Nasr, Roman J Krawetz, Neil A Duncan
The use of embryonic stem cells (ESC) in regenerative medicine is restricted due to the possibility of tumorigenicity after inefficient or incomplete differentiation. Studies from our group, and others, suggest that mechanical stimuli may have a suppressive effect on the pluripotency/tumorigenesis of murine ESC (mESC). Furthermore, we have demonstrated that mESC seeded in a type I collagen scaffold, and transplanted into a murine bone fracture model, demonstrated repair without tumor formation. However, it remains unknown if mechanical factors were involved in blocking tumorigenicity of the mESC...
October 4, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28944874/mechanical-stress-affects-the-osteogenic-differentiation-of-human-ligamentum%C3%A2-flavum-cells-via-the-bmp%C3%A2-smad1-signaling-pathway
#6
Yu Shunzhi, Li Zhonghai, Yan Ning
The aim of the present study was to investigate the effects of mechanical stress on the osteogenic differentiation of human ligamentum flavum cells via the bone morphogenetic protein (BMP)‑Smad1 signaling pathway. Mechanical stress increased cell proliferation and induced osteogenic differentiation of human cells derived from the ossification of the ligamentum flavum (OLF). In addition, mechanical stress activated osteocalcin (OC), alkaline phosphatase (ALP) and runt‑related transcription factor 2 (RUNX‑2) mRNA expression, and suppressed Ets proto‑oncogene 1 (Ets‑1) and sex determining region Y‑box 2 (SOX‑2) mRNA expression in OLF cells...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28934256/transcriptome-analysis-of-sex-related-genes-in-the-blood-clam-tegillarca-granosa
#7
COMPARATIVE STUDY
Heng Chen, Guoqiang Xiao, Xueliang Chai, Xingguan Lin, Jun Fang, Shuangshuang Teng
BACKGROUND: Blood clams (Tegillarca granosa) are one of the most commercial shellfish in China and South Asia with wide distribution in Indo-Pacific tropical to temperate estuaries. However, recent data indicate a decline in the germplasm of this species. Furthermore, the molecular mechanisms underpinning reproductive regulation remain unclear and information regarding genetic diversity is limited. Understanding the reproductive biology of shellfish is important in interpreting their embryology development, reproduction and population structure...
2017: PloS One
https://www.readbyqxmd.com/read/28926285/the-role-of-acrab-tolc-efflux-pump-in-mediating-fluoroquinolone-resistance-in-naturally-occurring-salmonella-isolates-from-china
#8
Jinling Shen, Baowei Yang, Qiang Gu, Guodong Zhang, Jielin Yang, Feng Xue, Jingdong Shao, Xiaojuan Yi, Yuan Jiang
The involvement of AcrAB-TolC efflux pump in regulating fluoroquinolone resistance of naturally occurring Salmonella isolates is insufficiently investigated. In this study, the regulatory genes, acrR, ramR, marRAB, and soxRS of AcrAB-TolC efflux pump, of 27 naturally occurring fluoroquinolone-resistant Salmonella isolates collected in China were sequenced. The expression levels of acrB, ramA, marA, and soxS were also examined using quantitative real-time polymerase chain reaction. Gene alterations were mainly observed for acrR (three mutation types) and ramR (four mutation types), not for marRAB (no mutation) or soxRS (one mutaton type)...
September 19, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28915439/alpha-mangostin-suppresses-interleukin-1%C3%AE-induced-apoptosis-in-rat-chondrocytes-by-inhibiting-the-nf-%C3%AE%C2%BAb-signaling-pathway-and-delays-the-progression-of-osteoarthritis-in-a-rat-model
#9
Tianlong Pan, Rong Chen, Dengying Wu, Ningyu Cai, Xuchao Shi, Bin Li, Jun Pan
Osteoarthritis (OA) is a chronic degenerative joint disease that is characterized by progressive joint dysfunction and pain. Apoptosis and catabolism in chondrocytes play critical roles in the development of OA. Alpha-Mangostin (α-MG), one of the main components of the mangosteen, has been reported to have anti-apoptotic, anti-inflammatory and antioxidant effects. We investigated the therapeutic effects of α-MG on OA through experiments on rat chondrocytes in vitro and in a rat model of OA induced by destabilization of the medial meniscus (DMM)...
November 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28910626/long-term-modelling-of-fly-ash-and-radionuclide-emissions-as-well-as-deposition-fluxes-due-to-the-operation-of-large-oil-shale-fired-power-plants
#10
Taavi Vaasma, Marko Kaasik, Jüri Loosaar, Madis Kiisk, Alan H Tkaczyk
Two of the world's largest oil shale-fired power plants (PPs) in Estonia have been operational over 40 years, emitting various pollutants, such as fly ash, SOx, NOx, heavy metals, volatile organic compounds as well as radionuclides to the environment. The emissions from these PPs have varied significantly during this period, with the maximum during the 1970s and 1980s. The oil shale burned in the PPs contains naturally occurring radionuclides from the (238)U and (232)Th decay series as well as (40)K. These radionuclides become enriched in fly ash fractions (up to 10 times), especially in the fine fly ash escaping the purification system...
September 11, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28900996/-clinicopathologic-characteristics-and-prognosis-of-gastric-hepatoid-adenocarcinoma
#11
Rongfei Zhao, Xinxin Wang, Xin Lan, Mingsen Li
OBJECTIVE: To investigate the clinicopathological characteristics, diagnosis, treatment and prognosis of gastric hepatoid adenocarcinoma(HAS). METHODS: Retrospective analysis of clinicopathological data of 24 cases with gastric HAS diagnosed by surgery and pathology in Chinese PLA General Hospital from January 2013 to May 2016 were carried out. All the patients underwent preoperative serum alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), endoscopy and imaging examination (CT or B-mode ultrasonography), and those with elevated AFP were excluded from liver cancer, cirrhosis, endodermal sinus tumor and other diseases...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28871209/hmgb1-advanced-glycation-end-products-rage-does-not-aggravate-inflammation-but-promote-endogenous-neural-stem-cells-differentiation-in-spinal-cord-injury
#12
Hongyu Wang, Xifan Mei, Yang Cao, Chang Liu, Ziming Zhao, Zhanpeng Guo, Yunlong Bi, Zhaoliang Shen, Yajiang Yuan, Yue Guo, Cangwei Song, Liangjie Bai, Yansong Wang, Deshui Yu
Receptor for advanced glycation end products (RAGE) signaling is involved in a series of cell functions after spinal cord injury (SCI). Our study aimed to elucidate the effects of RAGE signaling on the neuronal recovery after SCI. In vivo, rats were subjected to SCI with or without anti-RAGE antibodies micro-injected into the lesion epicenter. We detected Nestin/RAGE, SOX-2/RAGE and Nestin/MAP-2 after SCI by Western blot or immunofluorescence (IF). We found that neural stem cells (NSCs) co-expressed with RAGE were significantly activated after SCI, while stem cell markers Nestin and SOX-2 were reduced by RAGE blockade...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870830/an-improved-amperometric-creatinine-biosensor-based-on-nanoparticles-of-creatininase-creatinase-and-sarcosine-oxidase
#13
Parveen Kumar, Ranjana Jaiwal, C S Pundir
An improved amperometric biosensor for detection of creatinine was developed based on immobilization of nanoparticles (NPs) of creatininase (CA), creatinase (CI), and sarcosine oxidase (SOx) onto glassy carbon (GC) electrode. Transmission electron microscopy (TEM) and fourier transform infrared spectroscopy (FTIR) were employed for characterization of enzyme nanoparticles (ENPs). The GC electrode was characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV) and electrochemical impedance spectra (EIS) at different stages of its amendment...
September 1, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28861107/piwi-like-protein-hiwi2-is-aberrantly-expressed-in-retinoblastoma-cells-and-affects-cell-cycle-potentially-through-otx2
#14
Suganya Sivagurunathan, Jayamuruga Pandian Arunachalam, Subbulakshmi Chidambaram
Retinoblastoma (RB), a childhood cancer, is caused by biallelic mutation of the RB1 gene, but its development is not clearly understood. Furthermore, the presence of a cancer stem cell subpopulation in RB might impact its treatment. PIWI protein, known for its role in stem cell self-renewal, is aberrantly expressed in cancers. We examined the role of the PIWI-like protein HIWI2 in RB and its effect on the stem cell markers in cells of the RB line, Y79. The expression of HIWI2 is significantly increased in Y79 compared with its level in HeLa and ARPE19 cells...
2017: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/28851291/honokiol-improved-chondrogenesis-and-suppressed-inflammation-in-human-umbilical-cord-derived-mesenchymal-stem-cells-via-blocking-nuclear-factor-%C3%AE%C2%BAb-pathway
#15
Hao Wu, Zhanhai Yin, Ling Wang, Feng Li, Yusheng Qiu
BACKGROUND: Cartilage degradation is the significant pathological process in osteoarthritis (OA). Inflammatory cytokines, such as interleukin-1β (IL-1β), activate various downstream mediators contributing to OA pathology. Recently, stem cell-based cartilage repair emerges as a potential therapeutic strategy that being widely studied, whereas, the outcome is still far from clinical application. In this study, we focused on an anti-inflammatory agent, honokiol, which is isolated from an herb, investigated the potential effects on human umbilical cord derived mesenchymal stem cells (hUC-MSCs) in IL-1β stimulation...
August 29, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/28846679/microgrooved-surface-topography-enhances-cellular-division-and-proliferation-of-mouse-bone-marrow-derived-mesenchymal-stem-cells
#16
Jitendra Kumar Chaudhary, Pramod C Rath
Mesenchymal stem cells' (MSCs) fate is largely determined by the various topographical features and a range of extracellular matrix (ECM) components present in their niches. Apart from maintaining structural stability, they regulate cell morphology, division, proliferation, migration and differentiation among others. Traditional MSC cultures, which are mainly based on two-dimensional smooth surfaces of culture dishes and plates, do not provide topographical cues similar to in vivo three-dimensional niches, impacting various cellular processes...
2017: PloS One
https://www.readbyqxmd.com/read/28833141/transcriptional-profiling-of-human-neural-precursors-post-alcohol-exposure-reveals-impaired-neurogenesis-via-dysregulation-of-erk-signaling-and-mir-145
#17
Lithin K Louis, Renjitha Gopurappilly, Harshini Surendran, Sunit Dutta, Rajarshi Pal
Gestational alcohol exposure causes a range of neuropsychological disorders by modulating neurodevelopmental genes and proteins. The extent of damage depends on the stage of the embryo, as well as dosage, duration, and frequency of exposure. Here, we investigated the neurotoxic effects of alcohol using Human Embryonic Stem Cells (hESC). Multiple read-outs were engaged to assess the proliferation and differentiation capacity of neural precursor cells (NPC) upon exposure to 100 mM ethanol for 48 hrs corresponding to the blood alcohol levels for binge drinkers...
August 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28808812/antioxidant-effects-of-chrysin-loaded-electrospun-nanofibrous-mats-on-proliferation-and-stemness-preservation-of-human-adipose-derived-stem-cells
#18
Yaghoub Deldar, Faraz Zarghami, Younes Pilehvar-Soltanahmadi, Mehdi Dadashpour, Nosratollah Zarghami
An ideal biomaterial in regenerative medicine should be able to regulate the stem cell proliferation without the loss of its pluripotency. Chrysin (Chr) is a naturally occurring flavone with a wide spectrum of biological functions including anti-inflammatory and anti-oxidant properties. The present study describes the influence of Chr-loaded nanofibrous mats on the regulation of proliferation and stemness preservation of adipose-derived stem cells (ADSCs). For this purpose, Chr-loaded poly (ε-caprolactone)/poly (ethylene glycol) (PCL/PEG) nanofibrous mats were produced via electrospinning process and the successful fabrication of these bioactive mats was confirmed by field emission scanning electron microscopy (FE-SEM) and fourier transform infrared spectroscopy...
August 14, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28798167/complete-genome-sequence-of-sulfuriferula-sp-strain-ah1-a-sulfur-oxidizing-autotroph-isolated-from-weathered-mine-tailings-from-the-duluth-complex-in-minnesota
#19
Daniel S Jones, Elizabeth W Roepke, An An Hua, Beverly E Flood, Jake V Bailey
We report the closed and annotated genome sequence of Sulfuriferula sp. strain AH1. Strain AH1 has a 2,877,007-bp chromosome that includes a partial Sox system for inorganic sulfur oxidation and a complete nitrogen fixation pathway. It also has a single 39,138-bp plasmid with genes for arsenic and mercury resistance.
August 10, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28761727/s-1-and-oxaliplatin-sox-plus-bevacizumab-versus-mfolfox6-plus-bevacizumab-as-first-line-treatment-for-patients-with-metastatic-colorectal-cancer-updated-overall-survival-analyses-of-the-open-label-non-inferiority-randomised-phase-iii-soft-study
#20
Hideo Baba, Yasuhide Yamada, Daisuke Takahari, Hiroshi Matsumoto, Kazuhiro Yoshida, Masato Nakamura, Motoki Yoshida, Shigeyoshi Iwamoto, Ken Shimada, Yoshito Komatsu, Yasutsuna Sasaki, Taroh Satoh, Keiichi Takahashi, Hideyuki Mishima, Kei Muro, Masahiko Watanabe, Yuh Sakata, Satoshi Morita, Yasuhiro Shimada, Kenichi Sugihara
OBJECTIVE: The SOFT study previously demonstrated that S-1 and oxaliplatin (SOX) plus bevacizumab was non-inferior to l-leucovorin, fluorouracil and oxaliplatin (mFOLFOX6) plus bevacizumab in terms of the primary end point of progression-free survival (PFS) as first-line chemotherapy for metastatic colorectal cancer (mCRC). The overall survival (OS) data were immature at the time of the primary analysis. METHODS: A total of 512 patients were enrolled and randomly assigned to receive either mFOLFOX6 plus bevacizumab (5 mg/kg of bevacizumab, followed by 200 mg/m(2) of l-leucovorin given simultaneously with 85 mg/m(2) of oxaliplatin, followed by a 400 mg/m(2) bolus of 5-FU on day 1 and then 2400 mg/m(2) of 5-FU as an intravenous infusion over the course of 46 hours, every 2 weeks) or SOX plus bevacizumab (7...
2017: ESMO Open
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