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https://www.readbyqxmd.com/read/29650855/-a-case-of-double-cancer-of-intrahepatic-cholangiocarcinoma-and-gastric-carcinoma-with-difficult-diagnosis-of-the-primary-tumor-with-peritoneal-metastasis
#1
Hiroyuki Kanomata, Yasuji Seyama, Hiroki Kudo, Toru Tanizawa, Masahiro Warabi, Masamichi Takahashi, Yujiro Matsuoka, Ikuo Wada, Masayuki Takegami, Yukio Miyamoto, Nobutaka Umekita
Double cancer of intrahepatic cholangiocarcinoma and gastric cancer is rare. A 62-year-old man underwent gastrectomy for gastric cancer. The pathological findings were tub1>tub2, m, ly0, v0, n0, Stage I A. Two years and a month later, a liver tumor(diameter of 3 cm)and a pelvic mass(diameter of 2.5 cm)were observed. Metastasis from gastric cancer was suspected and chemotherapy(SOX)was administered. However, after 5 courses, CT revealed worseningof the liver tumor (diameter of 12 cm)and pelvic mass(diameter of 3 cm)...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650845/-a-case-report-of-sox-treatment-for-primary-duodenal-carcinoma-with-liver-metastasis
#2
Yuki Yokota, Hirotsugu Nagase, Kozo Noguchi, Atsushi Hamabe, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Yoshito Tomimaru, Tomono Kawase, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Keizo Dono
We report a case of effective S-1 plus oxaliplatin (SOX) treatment for duodenal cancer with liver metastases. The patient was a 70-year-old female diagnosed with duodenal carcinoma that was unresectable because of liver metastasis(cT4N1M1, cStage IV in UICC 7th). She received SOX treatment(100mg/m / 2 of oxaliplatin on day 1 combined with 40 mg/day of S-1 twice daily on days 1-14, was repeated every 3 weeks). After 4 courses, a partial response was confirmed by computed tomography and no severe adverse events were observed...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29622083/role-of-drug-transporters-and-heat-shock-proteins-during-ethanol-exposure-to-human-neural-precursor-cells-and-its-lineages
#3
Sandeep Kumar Vishwakarma, Nusrath Fatima, Chandrakala Lakkireddy, Nagarapu Raju, Avinash Bardia, A Sandhya, Syed Ameer Basha Paspala, Vishnupriya Satti, Aleem Ahmed Khan
INTRODUCTION: Ethanol exposure to developing brain may alter the growth and differentiation of neurological cells resulting in unfavorable pathologies. Earlier studies have provided very limited mechanistic insights of cellular and molecular mechanisms which do not mimic with human situation due to varying cell types and poses potential challenges for investigation. Therefore, the present study was undertaken to evaluate the role of ABC transporters and heat shock proteins mediated response in human neural precursor cells (NPCs) and its lineages during proliferation and lineage differentiation against ethanol exposure...
April 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29604386/applications-of-inflammation-derived-gingival-stem-cells-for-testing-the-biocompatibility-of-dental-restorative-biomaterials
#4
A Soancă, M Lupse, M Moldovan, E Pall, M Cenariu, A Roman, O Tudoran, P Surlin, O Șorițău
BACKGROUND: Normal or inflamed gingival tissues are regarded as a source of mesenchymal stem cells (MSCs) abundant and easily accessible through minimally invasive dental procedures. Due to the proximity of dental resin composites to gingival tissues and to the possible local cytotoxic effect of the eluted components, gingiva-derived MSCs could be used to investigate the biocompatibility of dental biomaterials. PURPOSE: The present research aimed to isolate (MSCs) from inflamed and normal gingiva, to fully characterize them and to observe their behavior in relation with some commercial resin composite materials and one experimental material...
March 28, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29593724/mirnome-expression-analysis-reveals-new-players-on-leprosy-immune-physiopathology
#5
Claudio Guedes Salgado, Pablo Pinto, Raquel Carvalho Bouth, Angélica Rita Gobbo, Ana Caroline Cunha Messias, Tatiana Vinasco Sandoval, André Mauricio Ribeiro Dos Santos, Fabiano Cordeiro Moreira, Amanda Ferreira Vidal, Luiz Ricardo Goulart, Josafá Gonçalves Barreto, Moisés Batista da Silva, Marco Andrey Cipriani Frade, John Stewart Spencer, Sidney Santos, Ândrea Ribeiro-Dos-Santos
Leprosy remains as a public health problem and its physiopathology is still not fully understood. MicroRNAs (miRNA) are small RNA non-coding that can interfere with mRNA to regulate gene expression. A few studies using DNA chip microarrays have explored the expression of miRNA in leprosy patients using a predetermined set of genes as targets, providing interesting findings regarding the regulation of immune genes. However, using a predetermined set of genes restricted the possibility of finding new miRNAs that might be involved in different mechanisms of disease...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29577332/human-placental-ppar-%C3%AE-sox2-expression-in-serologically-proved-toxoplasmosis
#6
Marwa Hasby Saad, Noha El-Anwar, Shereef Lotfy, Mohammed Fouda, Eiman Hasby
AIM: to explore PPAR-γ & SOX-2 transcription factors expression in placenta according to maternal anti-Toxoplasma gondii serological profile during pregnancy and pregnancy outcome. METHODS: The study included 240 placentas, grouped according to IgM & IgG sero-status, and then sub-grouped according to pregnancy outcome that varied between miscarriages, premature labor, still birth and giving birth to CNS anomaly or apparently healthy neonates. Samples were H&E stained, and histopathologically scored blindly...
March 26, 2018: Parasite Immunology
https://www.readbyqxmd.com/read/29577223/-effect-of-neoadjuvant-chemotherapy-on-nutritional-status-of-locally-advanced-gastric-cancer
#7
Guopeng Deng, Jianjun Qu, Shengyong Zhai, Yiran Shi, Xinbo Wang
OBJECTIVE: To study the effect of neoadjuvant chemotherapy on nutritional status in patients with locally advanced gastric cancer. METHODS: Cases inclusion criteria: (1)18-65 years old; (2) Gastric cancer confirmed by gastroscopic biopsy; (3) Preoperative TNM stage III( according to the AJCC stage 2000 standard; (4) Kamosfsky functional status score> 60 points; (5)Receiving neoadjuvant chemotherapy voluntarily and signing the informed consent form. Case exclusion criteria: (1)Having contraindications of chemotherapy and surgery; (2) Suffering from heart, liver and kidney and other underlying diseases; (3) Concurrent with malignant diseases, wasting disease or other digestive diseases...
March 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29562779/mapping-of-the-human-placenta-experimental-evidence-of-amniotic-epithelial-cell-heterogeneity
#8
Lucia Centurione, Francesca Passaretta, Maria Antonietta Centurione, Silvia De Munari, Elsa Vertua, Antonietta Silini, Marco Liberati, Ornella Parolini, Roberta Di Pietro
The human placenta is an important source of stem cells that can be easily collected without ethical concerns since it is usually discarded after childbirth. In this study, we analyzed the amniotic membrane (AM) from the human placenta with the aim of mapping different regions with respect to their morpho-functional features and regenerative potential. AMs were obtained from 24 healthy women, undergoing a caesarean section, and mapped into 4 different regions according to their position in relation to the umbilical cord: the central, intermediate, peripheral, and reflected areas...
January 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29555978/sema4c-plexinb2-signaling-controls-breast-cancer-cell-growth-hormonal-dependence-and-tumorigenic-potential
#9
Sreeharsha Gurrapu, Emanuela Pupo, Giulia Franzolin, Letizia Lanzetti, Luca Tamagnone
Semaphorin 4C (Sema4C) expression in human breast cancers correlates with poor disease outcome. Surprisingly, upon knock-down of Sema4C or its receptor PlexinB2 in diverse mammary carcinoma cells (but not their normal counterparts), we observed dramatic growth inhibition associated with impairment of G2/M phase transition, cytokinesis defects and the onset of cell senescence. Mechanistically, we demonstrated a Sema4C/PlexinB2/LARG-dependent signaling cascade that is required to maintain critical RhoA-GTP levels in cancer cells...
March 19, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29517421/development-of-a-polarized-pancreatic-ductular-cell-epithelia-for-physiological-studies
#10
Yunxia O'Malley, Pavana G Rotti, Ian M Thornell, Oriana G Vanegas Calderón, Christopher Febres-Aldana, Katelin Durham, Jianrong Yao, Xiaopeng Li, Zheng Zhu, Andrew W Norris, Joseph Zabner, John F Engelhardt, Aliye Uc
Pancreatic ductular epithelial cells comprise the majority of duct cells in pancreas, control cystic fibrosis transmembrane conductance regulator (CFTR)-dependent bicarbonate [HCO3 - ] secretion, but are difficult to grow as a polarized monolayer. Using NIH-3T3-J2 fibroblast feeder cells and a Rho-associated kinase inhibitor, we produced well-differentiated and polarized porcine pancreatic ductular epithelial cells. Cells grown on semipermeable filters at air-liquid interface (ALI) developed typical epithelial cell morphology and stable transepithelial resistance (TER), expressed epithelial cell markers (zona occludens-1 and beta catenin), duct cell markers (SOX-9 and CFTR), but no acinar (amylase) or islet cell (chromogranin) markers...
March 8, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29515059/subchondral-bone-derived-mesenchymal-stem-cells-display-enhanced-osteo-chondrogenic-differentiation-self-renewal-and-proliferation-potentials
#11
Hao Zhang, Zhong-Li Li, Xiang-Zheng Su, Li Ding, Ji Li, Heng Zhu
Rabbit mesenchymal stem cells (MSCs) are important seed cells in regenerative medicine research, particularly in translational research. In the current study, we showed that rabbit subchondral bone is a reliable source of MSCs. First, we harvested subchondral bone (SCB) from the rabbit knee-joint and initiated the MSC culture by cultivating enzyme-treated SCB. Adherent fibroblast-like cells that outgrew from SCB fulfill the common immuno-phenotypic criteria for defining MSCs, but with low contamination of CD45+ hematopoietic cells...
March 8, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29504365/layering-poly-lactic-co-glycolic-acid-based-electrospun-membranes-and-co-culture-cell-sheets-for-engineering-temporomandibular-joint-disc
#12
C-H Wang, S Wang, B Zhang, X-Y Zhang, X-J Tong, H-M Peng, X-Z Han, C Liu
The temporomandibular joint disk (TMJD) lacks blood vessels and is characterized by slow self-repair. Qualitative lesions in TMJD are difficult to repair. In this study, electrospun poly (lactic-co-glycolic acid) (PLGA) scaffolds were used to reconstruct temporomandibular joint discs by tissue engineering. Rabbit temporomandibular joint disc cells (TMJDCs) and rabbit synovium-derived mesenchymal stem cells (SMSCs) were co-cultured in 1:1 ratios. Cell sheets were induced by ascorbic acid incubated with electrospun PLGA scaffolds for 14 days in the presence (10 ng/ml in culture medium) or absence of TGF-β3...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29482257/histone-deacetylase-inhibitor-trapoxin-a-enhances-stemness-properties-in-adipose-tissue-derived-mesenchymal-stem-cells
#13
Leila Mousazadeh, Effat Alizadeh, Nosratollah Zarghami, Shahryar Hashemzadeh, Sedigheh Fekri Aval, Leili Hasanifard, Roya Herizchi
BACK GROUND: Adipose tissue derived mesenchymal stem cells (ASCs) have unique potential for regenerative cell therapies. However, during ex-vivo cultivation, they undergo considerable quality loss regarding their phenotypic properties, stemness genes expression and differentiation potential. Recent studies reported that the loss of stemness properties of MSCs is a result of chromatin histone deacetylations through in-vitro cultivation. The present work aimed to study the effect of Trapoxin A (TPX) as a histone deacetylase inhibitor (HDACi) on overall stemness properties of ASCs...
February 26, 2018: Drug Research
https://www.readbyqxmd.com/read/29480445/clinical-applications-of-induced-pluripotent-stem-cells-stato-attuale
#14
Chavali Kavyasudha, Dannie Macrin, K N ArulJothi, Joel P Joseph, M K Harishankar, Arikketh Devi
In an adult human body, somatic stem cells are present in small amounts in almost all organs with the function of general maintenance and prevention of premature aging. But, these stem cells are not pluripotent and are unable to regenerate large cellular loss caused by infarctions or fractures especially in cells with limited replicative ability such as neurons and cardiomyocytes. These limitations gave rise to the idea of inducing pluripotency to adult somatic cells and thereby restoring their regeneration, replication and plasticity...
February 27, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29477123/hierarchical-cuins-2-based-heterostructure-application-for-photocathodic-bioanalysis-of-sarcosine
#15
Xin-Yuan Jiang, Ling Zhang, Yi-Li Liu, Xiao-Dong Yu, Yan-Yu Liang, Peng Qu, Wei-Wei Zhao, Jing-Juan Xu, Hong-Yuan Chen
In this study, on the basis of hierarchical CuInS2 -based heterostructure, a novel cathodic photoelectrochemical (PEC) enzymatic bioanalysis of the sarcosine detection was reported. Specifically, heterostructured CuInS2 /NiO/ITO photocathode was prepared and sarcosine oxidases (SOx) were integrated for the construction of the enzymatic biosensor. In the bioanalysis, the O2 -dependent suppression of the cathodic photocurrent can be observed due to the competition between the as-fabricated O2 -sensitive photocathode and the SOx-catalytic event toward O2 reduction...
February 15, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29476247/effects-of-topical-topiramate-in-wound-healing-in-mice
#16
Carlos Poblete Jara, Vanessa Cristina Dias Bóbbo, Rodrigo Scarpari Carraro, Thiago Matos Ferreira de Araujo, Maria H M Lima, Licio A Velloso, Eliana P Araújo
Recent studies have indicated that systemic topiramate can induce an improvement on the aesthetic appearance of skin scars. Here, we evaluated topical topiramate as an agent to improve wound healing in C57/BL6 mice. Mice were inflicted with a 6.0 mm punch to create two wounds in the skin of the dorsal region. Thereafter, mice were randomly assigned to either vehicle or topical topiramate (20 µl of 2% cream) once a day for 14 days, beginning on the same day as wound generation. We analyzed the wound samples over real-time PCR, Western blotting, and microscopy...
February 23, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29472102/modeling-human-pancreatic-beta-cell-dedifferentiation
#17
Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann
OBJECTIVE: Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). METHODS: Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line, EndoC-βH1, and human pancreatic islets. RESULTS: Fibroblast growth factor 2 (FGF2) treatment reduced expression of β-cell markers, (INS, MAFB, SLC2A2, SLC30A8, and GCK) and activated ectopic expression of MYC, HES1, SOX9, and NEUROG3...
February 8, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29467236/hematopoietic-stem-cells-from-induced-pluripotent-stem-cells-considering-the-role-of-microrna-as-a-cell-differentiation-regulator
#18
REVIEW
Aline F Ferreira, George A Calin, Virgínia Picanço-Castro, Simone Kashima, Dimas T Covas, Fabiola A de Castro
Although hematopoietic stem cell (HSC) therapy for hematological diseases can lead to a good outcome from the clinical point of view, the limited number of ideal donors, the comorbidity of patients and the increasing number of elderly patients may limit the application of this therapy. HSCs can be generated from induced pluripotent stem cells (iPSCs), which requires the understanding of the bone marrow and liver niches components and function in vivo iPSCs have been extensively applied in several studies involving disease models, drug screening and cellular replacement therapies...
February 21, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29434914/long-non-coding-rna-malat-1-contributes-to-maintenance-of-stem-cell-like-phenotypes-in-breast-cancer-cells
#19
Linghuan Zeng, Ying Cen, Junjie Chen
Due to the accumulating evidence that has demonstrated the vital role of cancer stem cells (CSCs) in tumor initiation, progression and metastasis, the mechanisms that maintain the stemness of CSCs have attracted increasing attention. Metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1), a long non-coding RNA, which has been revealed to be associated with the malignant behavior of tumors, performs a critical role in maintaining the stemness in several CSCs. In the present study, it was hypothesized that MALAT-1 promotes stem cell-like phenotypes in breast cancer cells...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29422539/a-global-perspective-on-sulfur-oxide-controls-in-coal-fired-power-plants-and-cardiovascular-disease
#20
Cheng-Kuan Lin, Ro-Ting Lin, Pi-Cheng Chen, Pu Wang, Nathalie De Marcellis-Warin, Corwin Zigler, David C Christiani
Sulfur oxides (SOx), particularly SO2 emitted by coal-fired power plants, produce long-term risks for cardiovascular disease (CVD). We estimated the relative risks of CVD and ischemic heart disease (IHD) attributable to SOx emission globally. National SOx reduction achieved by emissions control systems was defined as the average SOx reduction percentage weighted by generating capacities of individual plants in a country. We analyzed the relative risk of CVD incidence associated with national SOx reduction for 13,581 coal-fired power-generating units in 79 countries...
February 8, 2018: Scientific Reports
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