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https://www.readbyqxmd.com/read/30337273/safety-tolerability-and-preliminary-efficacy-of-an-igf-1-mimetic-in-patients-with-spinal-and-bulbar-muscular-atrophy-a-randomised-placebo-controlled-trial
#1
Christopher Grunseich, Ram Miller, Therese Swan, David J Glass, Mohamed El Mouelhi, Mara Fornaro, Olivier Petricoul, Igor Vostiar, Ronenn Roubenoff, Matthew N Meriggioli, Angela Kokkinis, Robert D Guber, Maher S Budron, John Vissing, Gianni Soraru, Tahseen Mozaffar, Albert Ludolph, John T Kissel, Kenneth H Fischbeck
BACKGROUND: Spinal and bulbar muscular atrophy is an X-linked neuromuscular disease caused by CAG repeat expansion in the androgen receptor gene. Patients with this disease have low concentrations of insulin-like growth factor-1 (IGF-1), and studies of overexpression and administration of IGF-1 showed benefit in a transgenic model; thus the IGF-1 pathway presents as a potential treatment target. We assessed safety, tolerability, and preliminary efficacy of BVS857, an IGF-1 mimetic, in patients with spinal and bulbar muscular atrophy...
October 15, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30332405/peripherally-derived-macrophages-modulate-microglial-function-to-reduce-inflammation-after-cns-injury
#2
Andrew D Greenhalgh, Juan G Zarruk, Luke M Healy, Sam J Baskar Jesudasan, Priya Jhelum, Christopher K Salmon, Albert Formanek, Matthew V Russo, Jack P Antel, Dorian B McGavern, Barry W McColl, Samuel David
Infiltrating monocyte-derived macrophages (MDMs) and resident microglia dominate central nervous system (CNS) injury sites. Differential roles for these cell populations after injury are beginning to be uncovered. Here, we show evidence that MDMs and microglia directly communicate with one another and differentially modulate each other's functions. Importantly, microglia-mediated phagocytosis and inflammation are suppressed by infiltrating macrophages. In the context of spinal cord injury (SCI), preventing such communication increases microglial activation and worsens functional recovery...
October 17, 2018: PLoS Biology
https://www.readbyqxmd.com/read/30326855/prior-ct-imaging-history-for-patients-who-undergo-whole-body-ct-for-acute-traumatic-injury-and-are-discharged-home-from-the-emergency-department
#3
Mary Matthews, Peter Richman, Scott Krall, Kimberly Leeson, K Tom Xu, Albert L Gest, Osbert Blow
BACKGROUND: Recurrent CT imaging is believed to significantly increase lifetime malignancy risk. We previously reported that high acuity, admitted trauma patients who received a whole-body CT in the emergency department (ED) had a history of prior CT imaging in 14% of cases. The primary objective of this study was to determine the CT imaging history for trauma patients who received a whole-body CT but were ultimately deemed safe for discharge directly home from the ED. METHODS: This was a retrospective cohort study conducted at an academic ED...
October 16, 2018: BMC Emergency Medicine
https://www.readbyqxmd.com/read/30323087/nccn-guidelines-insights-small-cell-lung-cancer-version-2-2018
#4
Gregory P Kalemkerian, Billy W Loo, Wallace Akerley, Albert Attia, Michael Bassetti, Yanis Boumber, Roy Decker, M Chris Dobelbower, Afshin Dowlati, Robert J Downey, Charles Florsheim, Apar Kishor P Ganti, John C Grecula, Matthew A Gubens, Christine L Hann, James A Hayman, Rebecca Suk Heist, Marianna Koczywas, Robert E Merritt, Nisha Mohindra, Julian Molina, Cesar A Moran, Daniel Morgensztern, Saraswati Pokharel, David C Portnoy, Deborah Rhodes, Chad Rusthoven, Rafael Santana-Davila, Charles C Williams, Karin G Hoffmann, Miranda Hughes
The NCCN Guidelines for Small Cell Lung Cancer (SCLC) address all aspects of disease management. These NCCN Guidelines Insights focus on recent updates to the NCCN Guidelines for SCLC regarding immunotherapy, systemic therapy, and radiation therapy. For the 2018 update, new sections were added on "Signs and Symptoms of SCLC" and "Principles of Pathologic Review."
October 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/30321793/functional-impulse-based-quantification-of-plantar-pressure-patterns-in-typical-adult-gait
#5
Albert H Vette, Martha Funabashi, Justin Lewicke, Beth Watkins, Matthew Prowse, Graeme Harding, Anelise Silveira, Manu Saraswat, Sukhdeep Dulai
BACKGROUND: Dynamic pedobarography is used to measure the change in plantar pressure distribution during gait. Clinical methods of pedobarographic analysis lack, however, a standardized, functional segmentation or require costly motion capture technology and expertise. Furthermore, while commonly used pedobarographic measures are mostly based on peak pressures, progressive foot deformities also depend on the duration the pressure is applied, which can be quantified via impulse measures...
October 1, 2018: Gait & Posture
https://www.readbyqxmd.com/read/30305127/assessing-whether-universal-coverage-with-insecticide-treated-nets-has-been-achieved-is-the-right-indicator-being-used
#6
Hannah Koenker, Fred Arnold, Fatou Ba, Moustapha Cisse, Lamine Diouf, Erin Eckert, Marcy Erskine, Lia Florey, Megan Fotheringham, Lilia Gerberg, Christian Lengeler, Matthew Lynch, Abraham Mnzava, Susann Nasr, Médoune Ndiop, Stephen Poyer, Melanie Renshaw, Estifanos Shargie, Cameron Taylor, Julie Thwing, Suzanne Van Hulle, Yazoumé Ye, Josh Yukich, Albert Kilian
BACKGROUND/METHODS: Insecticide-treated nets (ITNs) are the primary tool for malaria vector control in sub-Saharan Africa, and have been responsible for an estimated two-thirds of the reduction in the global burden of malaria in recent years. While the ultimate goal is high levels of ITN use to confer protection against infected mosquitoes, it is widely accepted that ITN use must be understood in the context of ITN availability. However, despite nearly a decade of universal coverage campaigns, no country has achieved a measured level of 80% of households owning 1 ITN for 2 people in a national survey...
October 11, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30304008/where-am-i-in-virtual-reality
#7
Albert H van der Veer, Adrian J T Alsmith, Matthew R Longo, Hong Yu Wong, Betty J Mohler
It is currently not well understood whether people experience themselves to be located in one or more specific part(s) of their body. Virtual reality (VR) is increasingly used as a tool to study aspects of bodily perception and self-consciousness, due to its strong experimental control and ease in manipulating multi-sensory aspects of bodily experience. To investigate where people self-locate in their body within virtual reality, we asked participants to point directly at themselves with a virtual pointer, in a VR headset...
2018: PloS One
https://www.readbyqxmd.com/read/30283106/very-high-energy-particle-acceleration-powered-by-the-jets-of-the-microquasar-ss-433
#8
A U Abeysekara, A Albert, R Alfaro, C Alvarez, J D Álvarez, R Arceo, J C Arteaga-Velázquez, D Avila Rojas, H A Ayala Solares, E Belmont-Moreno, S Y BenZvi, C Brisbois, K S Caballero-Mora, T Capistrán, A Carramiñana, S Casanova, M Castillo, U Cotti, J Cotzomi, S Coutiño de León, C De León, E De la Fuente, J C Díaz-Vélez, S Dichiara, B L Dingus, M A DuVernois, R W Ellsworth, K Engel, C Espinoza, K Fang, H Fleischhack, N Fraija, A Galván-Gámez, J A García-González, F Garfias, A González-Muñoz, M M González, J A Goodman, Z Hampel-Arias, J P Harding, S Hernandez, J Hinton, B Hona, F Hueyotl-Zahuantitla, C M Hui, P Hüntemeyer, A Iriarte, A Jardin-Blicq, V Joshi, S Kaufmann, P Kar, G J Kunde, R J Lauer, W H Lee, H León Vargas, H Li, J T Linnemann, A L Longinotti, G Luis-Raya, R López-Coto, K Malone, S S Marinelli, O Martinez, I Martinez-Castellanos, J Martínez-Castro, J A Matthews, P Miranda-Romagnoli, E Moreno, M Mostafá, A Nayerhoda, L Nellen, M Newbold, M U Nisa, R Noriega-Papaqui, J Pretz, E G Pérez-Pérez, Z Ren, C D Rho, C Rivière, D Rosa-González, M Rosenberg, E Ruiz-Velasco, F Salesa Greus, A Sandoval, M Schneider, H Schoorlemmer, M Seglar Arroyo, G Sinnis, A J Smith, R W Springer, P Surajbali, I Taboada, O Tibolla, K Tollefson, I Torres, G Vianello, L Villaseñor, T Weisgarber, F Werner, S Westerhoff, J Wood, T Yapici, G Yodh, A Zepeda, H Zhang, H Zhou
SS 433 is a binary system containing a supergiant star that is overflowing its Roche lobe with matter accreting onto a compact object (either a black hole or neutron star)1-3 . Two jets of ionized matter with a bulk velocity of approximately 0.26c (where c is the speed of light in vacuum) extend from the binary, perpendicular to the line of sight, and terminate inside W50, a supernova remnant that is being distorted by the jets2,4-8 . SS 433 differs from other microquasars (small-scale versions of quasars that are present within our own Galaxy) in that the accretion is believed to be super-Eddington9-11 , and the luminosity of the system is about 1040 ergs per second2,9,12,13 ...
October 2018: Nature
https://www.readbyqxmd.com/read/30258056/genome-wide-association-study-of-23-500-individuals-identifies-7-loci-associated-with-brain-ventricular-volume
#9
Dina Vojinovic, Hieab H Adams, Xueqiu Jian, Qiong Yang, Albert Vernon Smith, Joshua C Bis, Alexander Teumer, Markus Scholz, Nicola J Armstrong, Edith Hofer, Yasaman Saba, Michelle Luciano, Manon Bernard, Stella Trompet, Jingyun Yang, Nathan A Gillespie, Sven J van der Lee, Alexander Neumann, Shahzad Ahmad, Ole A Andreassen, David Ames, Najaf Amin, Konstantinos Arfanakis, Mark E Bastin, Diane M Becker, Alexa S Beiser, Frauke Beyer, Henry Brodaty, R Nick Bryan, Robin Bülow, Anders M Dale, Philip L De Jager, Ian J Deary, Charles DeCarli, Debra A Fleischman, Rebecca F Gottesman, Jeroen van der Grond, Vilmundur Gudnason, Tamara B Harris, Georg Homuth, David S Knopman, John B Kwok, Cora E Lewis, Shuo Li, Markus Loeffler, Oscar L Lopez, Pauline Maillard, Hanan El Marroun, Karen A Mather, Thomas H Mosley, Ryan L Muetzel, Matthias Nauck, Paul A Nyquist, Matthew S Panizzon, Zdenka Pausova, Bruce M Psaty, Ken Rice, Jerome I Rotter, Natalie Royle, Claudia L Satizabal, Reinhold Schmidt, Peter R Schofield, Pamela J Schreiner, Stephen Sidney, David J Stott, Anbupalam Thalamuthu, Andre G Uitterlinden, Maria C Valdés Hernández, Meike W Vernooij, Wei Wen, Tonya White, A Veronica Witte, Katharina Wittfeld, Margaret J Wright, Lisa R Yanek, Henning Tiemeier, William S Kremen, David A Bennett, J Wouter Jukema, Tomas Paus, Joanna M Wardlaw, Helena Schmidt, Perminder S Sachdev, Arno Villringer, Hans Jörgen Grabe, W T Longstreth, Cornelia M van Duijn, Lenore J Launer, Sudha Seshadri, M Arfan Ikram, Myriam Fornage
The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22...
September 26, 2018: Nature Communications
https://www.readbyqxmd.com/read/30254314/fine-mapping-of-mhc-region-in-lung-cancer-highlights-independent-susceptibility-loci-by-ethnicity
#10
Aida Ferreiro-Iglesias, Corina Lesseur, James McKay, Rayjean J Hung, Younghun Han, Xuchen Zong, David Christiani, Mattias Johansson, Xiangjun Xiao, Yafang Li, David C Qian, Xuemei Ji, Geoffrey Liu, Neil Caporaso, Ghislaine Scelo, David Zaridze, Anush Mukeriya, Milica Kontic, Simona Ognjanovic, Jolanta Lissowska, Małgorzata Szołkowska, Beata Swiatkowska, Vladimir Janout, Ivana Holcatova, Ciprian Bolca, Milan Savic, Miodrag Ognjanovic, Stig Egil Bojesen, Xifeng Wu, Demetrios Albanes, Melinda C Aldrich, Adonina Tardon, Ana Fernandez-Somoano, Guillermo Fernandez-Tardon, Loic Le Marchand, Gadi Rennert, Chu Chen, Jennifer Doherty, Gary Goodman, Heike Bickeböller, H-Erich Wichmann, Angela Risch, Albert Rosenberger, Hongbing Shen, Juncheng Dai, John K Field, Michael Davies, Penella Woll, M Dawn Teare, Lambertus A Kiemeney, Erik H F M van der Heijden, Jian-Min Yuan, Yun-Chul Hong, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Ming-Sound Tsao, Mikael Johansson, Kjell Grankvist, Matthew B Schabath, Angeline Andrew, Eric Duell, Olle Melander, Hans Brunnström, Philip Lazarus, Susanne Arnold, Stacey Slone, Jinyoung Byun, Ahsan Kamal, Dakai Zhu, Maria Teresa Landi, Christopher I Amos, Paul Brennan
Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities...
September 25, 2018: Nature Communications
https://www.readbyqxmd.com/read/30254270/sex-and-species-specific-hearing-mechanisms-in-mosquito-flagellar-ears
#11
Matthew P Su, Marta Andrés, Nicholas Boyd-Gibbins, Jason Somers, Joerg T Albert
Hearing is essential for the courtship of one of the major carriers of human disease, the mosquito. Males locate females through flight-tone recognition and both sexes engage in mid-air acoustic communications, which can take place within swarms containing thousands of individuals. Despite the importance of hearing for mosquitoes, its mechanisms are still largely unclear. We here report a multilevel analysis of auditory function across three disease-transmitting mosquitoes (Aedes aegypti, Anopheles gambiae and Culex quinquefasciatus)...
September 25, 2018: Nature Communications
https://www.readbyqxmd.com/read/30248212/-19-f-mri-of-the-lungs-using-inert-fluorinated-gases-challenges-and-new-developments
#12
REVIEW
Marcus J Couch, Iain K Ball, Tao Li, Matthew S Fox, Birubi Biman, Mitchell S Albert
Fluorine-19 (19 F) MRI using inhaled inert fluorinated gases is an emerging technique that can provide functional images of the lungs. Inert fluorinated gases are nontoxic, abundant, relatively inexpensive, and the technique can be performed on any MRI scanner with broadband multinuclear imaging capabilities. Pulmonary 19 F MRI has been performed in animals, healthy human volunteers, and in patients with lung disease. In this review, the technical requirements of 19 F MRI are discussed, along with various imaging approaches used to optimize the image quality...
September 24, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/30242022/immunotherapy-targeting-hpv-16-18-generates-potent-immune-responses-in-hpv-associated-head-and-neck-cancer
#13
Charu Aggarwal, Roger B Cohen, Matthew P Morrow, Kimberly A Kraynak, Albert J Sylvester, Dawson M Knoblock, Joshua Bauml, Gregory S Weinstein, Alexander Lin, Jean Boyer, Lindsay Sakata, Sophie Tan, Aubrey Anton, Kelsie Dickerson, Drishty Mangrolia, Russell Vang, Michael Dallas, Sandra Oyola, Susan Duff, Mark T Esser, Rakesh Kumar, David B Weiner, Ildiko Csiki, Mark Bagarazzi
PURPOSE: Clinical responses with programmed death (PD-1) receptor directed antibodies occur in about 20% of patients with advanced head and neck squamous cell cancer (HNSCCa). Viral neoantigens, such as the E6/E7 proteins of HPV16/18 are attractive targets for therapeutic immunization, and offer an immune activation strategy that may be complementary to PD-1 inhibition. EXPERIMENTAL DESIGN: We report Phase Ib/II safety, tolerability and immunogenicity results of immunotherapy with MEDI0457 (DNA immunotherapy targeting HPV16/18 E6/E7 with IL-12 encoding plasmids) delivered by electroporation with CELLECTRA® constant current device...
September 21, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30219502/uv-screening-and-springtime-recovery-of-photosynthetic-capacity-in-leaves-of-vaccinium-vitis-idaea-above-and-below-the-snow-pack
#14
Twinkle Solanki, Pedro J Aphalo, Santa Neimane, Saara M Hartikainen, Marta Pieristè, Alexey Shapiguzov, Albert Porcar-Castell, Jon Atherton, Anu Heikkilä, Thomas Matthew Robson
Evergreen plants in boreal biomes undergo seasonal hardening and dehardening adjusting their photosynthetic capacity and photoprotection; acclimating to seasonal changes in temperature and irradiance. Leaf epidermal ultraviolet (UV)-screening by flavonols responds to solar radiation, perceived in part through increased ultraviolet-B (UV-B) radiation, and is a candidate trait to provide cross-photoprotection. At Hyytiälä Forestry Station, central Finland, we examined whether the accumulation of flavonols was higher in leaves of Vaccinium vitis-idaea L...
September 8, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/30217301/lower-survival-after-right-sided-versus-left-sided-colon-cancers-is-an-extended-lymphadenectomy-the-answer
#15
Lawrence Lee, Arman Erkan, Noura Alhassan, Justin J Kelly, George J Nassif, Matthew R Albert, John Rt Monson
INTRODUCTION: Tumour location may affect oncologic outcomes for colon adenocarcinoma due to different levels of vascular ligation and nodal harvest, but the data are equivocal. The objective of this study is to determine the effect of tumor location and lymph node yield on overall survival(OS) in stage I-III colon adenocarcinoma. METHODS: The 2004-2014 National Cancer Database was queried for colectomies for non-metastatic colon adenocarcinoma, excluding transverse colon and rectal cancer...
September 2018: Surgical Oncology
https://www.readbyqxmd.com/read/30199657/omega-3-fatty-acids-and-genome-wide-interaction-analyses-reveal-dpp10-pulmonary-function-association
#16
Jiayi Xu, Nathan C Gaddis, Traci M Bartz, Ruixue Hou, Ani W Manichaikul, Nathan Pankratz, Albert V Smith, Fangui Sun, Natalie Terzikhan, Christina A Markunas, Bonnie K Patchen, Matthew Schu, May A Beydoun, Guy G Brusselle, Gudny Eiriksdottir, Xia Zhou, Alexis C Wood, Mariaelisa Graff, Tamara B Harris, M Arfan Ikram, David R Jacobs, Lenore J Launer, Rozenn N Lemaitre, George O'Connor, Elizabeth C Oelsner, Bruce M Psaty, Vasan S Ramachandran, Rebecca R Rohde, Stephen S Rich, Jerome I Rotter, Sudha Seshadri, Lewis J Smith, Henning Tiemeier, Michael Y Tsai, André G Uitterlinden, V Saroja Voruganti, Hanfei Xu, Nuno R Zilhão, Myriam Fornage, M Carola Zillikens, Stephanie J London, R Graham Barr, Josée Dupuis, Sina A Gharib, Vilmundur Gudnason, Lies Lahousse, Kari E North, Lyn M Steffen, Patricia A Cassano, Dana B Hancock
RATIONALE: Omega-3 poly-unsaturated fatty acids (n-3 PUFAs) have anti-inflammatory properties that could benefit adults with comprised pulmonary health. OBJECTIVE: To investigate n-3 PUFA associations with spirometric measures of pulmonary function tests (PFTs) and determine underlying genetic susceptibility. METHODS: Associations of n-3 PUFA biomarkers (alpha-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid [DPA], and docosahexaenoic acid [DHA]) were evaluated with PFTs (forced expiratory volume in the first second [FEV1 ], forced vital capacity [FVC], and [FEV1 /FVC]) in meta-analyses across seven cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (N=16,134 of European or African ancestry)...
September 10, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30185651/human-thymopoiesis-is-influenced-by-a-common-genetic-variant-within-the-tcra-tcrd-locus
#17
Emmanuel Clave, Itauá Leston Araujo, Cécile Alanio, Etienne Patin, Jacob Bergstedt, Alejandra Urrutia, Silvia Lopez-Lastra, Yan Li, Bruno Charbit, Cameron Ross MacPherson, Milena Hasan, Breno Luiz Melo-Lima, Corinne Douay, Noémie Saut, Marine Germain, David-Alexandre Trégouët, Pierre-Emmanuel Morange, Magnus Fontes, Darragh Duffy, James P Di Santo, Lluis Quintana-Murci, Matthew L Albert, Antoine Toubert
The thymus is the primary lymphoid organ where naïve T cells are generated; however, with the exception of age, the parameters that govern its function in healthy humans remain unknown. We characterized the variability of thymic function among 1000 age- and sex-stratified healthy adults of the Milieu Intérieur cohort, using quantification of T cell receptor excision circles (TRECs) in peripheral blood T cells as a surrogate marker of thymopoiesis. Age and sex were the only nonheritable factors identified that affect thymic function...
September 5, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/30157874/associations-between-the-maternal-circulating-lipid-profile-in-pregnancy-and-fetal-imprinted-gene-alleles-a-cohort-study
#18
Clive J Petry, Albert Koulman, Liangjian Lu, Benjamin Jenkins, Samuel Furse, Philippa Prentice, Lee Matthews, Ieuan A Hughes, Carlo L Acerini, Ken K Ong, David B Dunger
BACKGROUND: Imprinted genes, which are expressed in a parent of origin-specific manner, are thought to mediate the genetic priorities of each parent in pregnancy. Recently we reported that some fetal imprinted gene variants are associated with maternal glucose concentrations and blood pressures in pregnancy. We suggest that the conflict between the effects of paternal and maternal transmitted genes starts at conception and may already be evident in measures of maternal metabolism in early pregnancy, before gestational diabetes is manifest...
August 29, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/30131338/thioridazine-inhibits-self-renewal-in-breast-cancer-cells-via-drd2-dependent-stat3-inhibition-but-induces-a-g-1-arrest-independent-of-drd2
#19
Matthew Tegowski, Cheng Fan, Albert S Baldwin
Thioridazine is an antipsychotic that has been shown to induce cell death and inhibit self-renewal in a broad spectrum of cancer cells. The mechanisms by which these effects are mediated are currently unknown but are presumed to result from the inhibition of dopamine receptor 2 (DRD2). Here we show that the self-renewal of several, but not all, triple-negative breast cancer cell lines is inhibited by thioridazine. The inhibition of self-renewal by thioridazine in these cells is mediated by DRD2 inhibition. Further, we demonstrate that DRD2 promotes self-renewal in these cells via a STAT3- and IL-6-dependent mechanism...
October 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/30127397/ltr-retrotransposons-transcribed-in-oocytes-drive-species-specific-and-heritable-changes-in-dna-methylation
#20
Julie Brind'Amour, Hisato Kobayashi, Julien Richard Albert, Kenjiro Shirane, Akihiko Sakashita, Asuka Kamio, Aaron Bogutz, Tasuku Koike, Mohammad M Karimi, Louis Lefebvre, Tomohiro Kono, Matthew C Lorincz
De novo DNA methylation (DNAme) during mouse oogenesis occurs within transcribed regions enriched for H3K36me3. As many oocyte transcripts originate in long terminal repeats (LTRs), which are heterogeneous even between closely related mammals, we examined whether species-specific LTR-initiated transcription units (LITs) shape the oocyte methylome. Here we identify thousands of syntenic regions in mouse, rat, and human that show divergent DNAme associated with private LITs, many of which initiate in lineage-specific LTR retrotransposons...
August 20, 2018: Nature Communications
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