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https://www.readbyqxmd.com/read/30086178/beached-bachelors-an-extensive-study-on-the-largest-recorded-sperm-whale-physeter-macrocephalus-mortality-event-in-the-north-sea
#1
Lonneke L IJsseldijk, Abbo van Neer, Rob Deaville, Lineke Begeman, Marco van de Bildt, Judith M A van den Brand, Andrew Brownlow, Richard Czeck, Willy Dabin, Mariel Ten Doeschate, Vanessa Herder, Helena Herr, Jooske IJzer, Thierry Jauniaux, Lasse Fast Jensen, Paul D Jepson, Wendy Karen Jo, Jan Lakemeyer, Kristina Lehnert, Mardik F Leopold, Albert Osterhaus, Matthew W Perkins, Uwe Piatkowski, Ellen Prenger-Berninghoff, Ralf Pund, Peter Wohlsein, Andrea Gröne, Ursula Siebert
Between the 8th January and the 25th February 2016, the largest sperm whale Physeter macrocephalus mortality event ever recorded in the North Sea occurred with 30 sperm whales stranding in five countries within six weeks. All sperm whales were immature males. Groups were stratified by size, with the smaller animals stranding in the Netherlands, and the largest in England. The majority (n = 27) of the stranded animals were necropsied and/or sampled, allowing for an international and comprehensive investigation into this mortality event...
2018: PloS One
https://www.readbyqxmd.com/read/30086053/impact-of-tumor-deposits-on-oncologic-outcomes-in-stage-iii-colon-cancer
#2
Nathalie Wong-Chong, Jill Motl, Grace Hwang, George J Nassif, Matthew R Albert, John R T Monson, Lawrence Lee
BACKGROUND: The prognosis of tumor deposits in stage III colon adenocarcinoma is poorly described. OBJECTIVE: The purpose of this study was to determine the impact of tumor deposits on oncologic outcomes in patients with stage III colon cancer. DESIGN: This was a multicenter retrospective cohort study. SETTINGS: The 2010 to 2014 National Cancer Database was queried for patients with resected stage III colon adenocarcinoma on final pathology...
September 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/30085955/a-panel-management-and-patient-navigation-intervention-is-associated-with-earlier-prep-initiation-in-a-safety-net-primary-care-health-system
#3
Matthew A Spinelli, Hyman M Scott, Eric Vittinghoff, Albert Y Liu, Alicia Morehead-Gee, Rafael Gonzalez, Monica Gandhi, Susan P Buchbinder
BACKGROUND: Timely pre-exposure prophylaxis (PrEP) initiation is critical in at-risk populations given that HIV acquisition risk persists during delays. Time to treatment initiation, a key metric in HIV care, has not been explored among PrEP users. Interventions that reduce time to PrEP initiation could prevent HIV infections. SETTING: Individuals initiating PrEP in a large, primary care health network of 15 clinics, the San Francisco Primary Care Clinics (SFPCC) from July 2012-July 2017 (N=411)...
August 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/30054318/transvenous-coil-embolization-with-intra-operative-cone-beam-ct-assistance-in-the-treatment-of-hypoglossal-canal-dural-arteriovenous-fistulae
#4
Matthew Thomas Crockett, Albert Ho Yuen Chiu, Tejinder P Singh, William McAuliffe, Timothy John Phillips
BACKGROUND: Hypoglossal canal dural arteriovenous fistulae (HC-dAVF) are a rare subtype of skull base fistulae involving the anterior condylar confluence or anterior condular vein within the hypoglossal canal. Transvenous coil embolization is a preferred treatment strategy, however delineation of fistula angio-architecture during workup and localization of microcatheter tip during embolization remain challenging on planar DSA. For this reason, our group have utilized intra-operative cone beam CT (CBCT) and selective cone beam CT angiography (sCBCTA) as adjuncts to planar DSA during workup and treatment...
July 27, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/30053915/human-genetic-variants-and-age-are-the-strongest-predictors-of-humoral-immune-responses-to-common-pathogens-and-vaccines
#5
Petar Scepanovic, Cécile Alanio, Christian Hammer, Flavia Hodel, Jacob Bergstedt, Etienne Patin, Christian W Thorball, Nimisha Chaturvedi, Bruno Charbit, Laurent Abel, Lluis Quintana-Murci, Darragh Duffy, Matthew L Albert, Jacques Fellay
BACKGROUND: Humoral immune responses to infectious agents or vaccination vary substantially among individuals, and many of the factors responsible for this variability remain to be defined. Current evidence suggests that human genetic variation influences (i) serum immunoglobulin levels, (ii) seroconversion rates, and (iii) intensity of antigen-specific immune responses. Here, we evaluated the impact of intrinsic (age and sex), environmental, and genetic factors on the variability of humoral response to common pathogens and vaccines...
July 27, 2018: Genome Medicine
https://www.readbyqxmd.com/read/30040054/knowledge-attitudes-and-practices-of-west-africans-on-genetic-studies-of-stroke-evidence-from-the-siren-study
#6
Rufus O Akinyemi, Fred S Sarfo, Joshua Akinyemi, Arti Singh, Matthew Onoja Akpa, Albert Akpalu, Lukman Owolabi, Abiodun M Adeoye, Reginald Obiako, Kolawole Wahab, Emmanuel Sanya, Morenikeji Komolafe, Godwin Ogbole, Michael Fawale, Philip Adebayo, Godwin Osaigbovo, Taofiki Sunmonu, Paul Olowoyo, Innocent Chukwuonye, Yahaya Obiabo, Olaleye Adeniji, Gregory Fakunle, Ezinne Melikam, Raelle Saulson, Joseph Yaria, Kelechi Uwanruochi, Phillip Ibinaiye, Ganiyu Adeniyi Amusa, Isah Suleiman Yahaya, Abdullahi Hamisu Dambatta, Mercy Faniyan, Peter Olowoniyi, Andrew Bock-Oruma, Odo Chidi Joseph, Ayodipupo Oguntade, Philip Kolo, Ruth Laryea, Sulaiman Lakoh, Ezinne Uvere, Temitope Farombi, Josephine Akpalu, Olalekan Oyinloye, Lambert Appiah, Benedict Calys-Tagoe, Vincent Shidali, Nasir Abdulkadir Tabari, Oladimeji Adebayo, Richard Efidi, Osi Adeleye, Dorcas Owusu, Luqman Ogunjimi, Olumayowa Aridegbe, Chidiebere Lucius Imoh, Taofeeq Sanni, Mulugeta Gebreziabher, Tiwari Hemant, Oyedunni Arulogun, Adesola Ogunniyi, Carolyn Jenkins, Mayowa Owolabi, Bruce Ovbiagele
Background It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire...
July 24, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30026741/interplay-of-ddp4-and-ip-10-as-a-potential-mechanism-for-cell-recruitment-to-tuberculosis-lesions
#7
Thomas Blauenfeldt, Linda Petrone, Franca Del Nonno, Andrea Baiocchini, Laura Falasca, Teresa Chiacchio, Vincent Bondet, Valentina Vanini, Fabrizio Palmieri, Gianni Galluccio, Armanda Casrouge, Jesper Eugen-Olsen, Matthew L Albert, Delia Goletti, Darragh Duffy, Morten Ruhwald
Introduction: Mycobacterium tuberculosis is one of the world's most successful pathogens equipped to establish itself within the human host as a subclinical infection without overt disease. Unable to eradicate the bacteria, the immune system contains the infection in a granuloma structure. Th1 cells that are essential for infection control are recruited to the site of infection directed by chemokines, predominantly CXCL10. It has previously been shown that CXCL10 in the plasma of patients chronically infected with hepatitis C virus is present primarily in an antagonist form...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30017480/the-iceman-s-last-meal-consisted-of-fat-wild-meat-and-cereals
#8
Frank Maixner, Dmitrij Turaev, Amaury Cazenave-Gassiot, Marek Janko, Ben Krause-Kyora, Michael R Hoopmann, Ulrike Kusebauch, Mark Sartain, Gea Guerriero, Niall O'Sullivan, Matthew Teasdale, Giovanna Cipollini, Alice Paladin, Valeria Mattiangeli, Marco Samadelli, Umberto Tecchiati, Andreas Putzer, Mine Palazoglu, John Meissen, Sandra Lösch, Philipp Rausch, John F Baines, Bum Jin Kim, Hyun-Joo An, Paul Gostner, Eduard Egarter-Vigl, Peter Malfertheiner, Andreas Keller, Robert W Stark, Markus Wenk, David Bishop, Daniel G Bradley, Oliver Fiehn, Lars Engstrand, Robert L Moritz, Philip Doble, Andre Franke, Almut Nebel, Klaus Oeggl, Thomas Rattei, Rudolf Grimm, Albert Zink
The history of humankind is marked by the constant adoption of new dietary habits affecting human physiology, metabolism, and even the development of nutrition-related disorders. Despite clear archaeological evidence for the shift from hunter-gatherer lifestyle to agriculture in Neolithic Europe [1], very little information exists on the daily dietary habits of our ancestors. By undertaking a complementary -omics approach combined with microscopy, we analyzed the stomach content of the Iceman, a 5,300-year-old European glacier mummy [2, 3]...
July 23, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29998391/defining-the-learning-curve-for-transanal-total-mesorectal-excision-for-rectal-adenocarcinoma
#9
Lawrence Lee, Justin Kelly, George J Nassif, Teresa C deBeche-Adams, Matthew R Albert, John R T Monson
BACKGROUND: Early observational data suggest that this approach is safe and feasible, but it is technically challenging and the learning curve has not yet been determined. The objective of this study was to determine the number of cases required achieve proficiency in transanal total mesorectal excision (TA-TME) for rectal adenocarcinoma. METHODS: All TA-TME cases performed from 03/2012-01/2017 at a single high-volume tertiary care institution for rectal adenocarcinoma were included...
July 11, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29995906/gene-flow-and-genetic-structure-in-nile-perch-lates-niloticus-from-african-freshwater-rivers-and-lakes
#10
Rose K Basiita, Kyall R Zenger, Matthew T Mwanja, Dean R Jerry
BACKGROUND: Geological evolution of the African continent has been subject to complex processes including uplift, volcanism, desert formation and tectonic rifting. This complex geology has created substantial biogeographical barriers, and coupled with anthropogenic introductions of freshwater fishes, has influenced the genetic diversity, connectivity and sub-structuring of the teleost fauna. Nile perch, Lates niloticus, is an iconic fish in Africa and is of high commercial importance, both in the species' native range and where it has been translocated...
2018: PloS One
https://www.readbyqxmd.com/read/29991877/gastric-cancer-in-alaska-native-people-a-cancer-health-disparity
#11
Holly A Martinson, Nancy J Shelby, Steven R Alberts, Matthew J Olnes
AIM: To evaluate recent trends in gastric cancer incidence, response to treatment, and overall survival among Alaska Native (AN) people. METHODS: A retrospective analysis of the Alaska Native Medical Center patient database was performed. Patient history, clinical, pathological, response to treatment and patient outcomes were collected from one-hundred and thirty-two AN gastric cancer patients. The Surveillance, Epidemiology and End Result database 18 was used to collect comparison United States non-Hispanic White (NHW) and AN gastric cancer patient data between 2006-2014...
July 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29988126/reducing-protein-oxidation-reverses-lung-fibrosis
#12
Vikas Anathy, Karolyn G Lahue, David G Chapman, Shi B Chia, Dylan T Casey, Reem Aboushousha, Jos L J van der Velden, Evan Elko, Sidra M Hoffman, David H McMillan, Jane T Jones, James D Nolin, Sarah Abdalla, Robert Schneider, David J Seward, Elle C Roberson, Matthew D Liptak, Morgan E Cousins, Kelly J Butnor, Douglas J Taatjes, Ralph C Budd, Charles G Irvin, Ye-Shih Ho, Razq Hakem, Kevin K Brown, Reiko Matsui, Markus M Bachschmid, Jose L Gomez, Naftali Kaminski, Albert van der Vliet, Yvonne M W Janssen-Heininger
Idiopathic pulmonary fibrosis is characterized by excessive deposition of collagen in the lung, leading to chronically impaired gas exchange and death1-3 . Oxidative stress is believed to be critical in this disease pathogenesis4-6 , although the exact mechanisms remain enigmatic. Protein S-glutathionylation (PSSG) is a post-translational modification of proteins that can be reversed by glutaredoxin-1 (GLRX)7 . It remains unknown whether GLRX and PSSG play a role in lung fibrosis. Here, we explored the impact of GLRX and PSSG status on the pathogenesis of pulmonary fibrosis, using lung tissues from subjects with idiopathic pulmonary fibrosis, transgenic mouse models and direct administration of recombinant Glrx to airways of mice with existing fibrosis...
July 9, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29987877/systemic-dpp4-activity-is-reduced-during-primary-hiv-1-infection-and-is-associated-with-intestinal-rorc-cd4-cell-levels-a-surrogate-marker-candidate-of-hiv-induced-intestinal-damage
#13
Mickaël J Ploquin, Armanda Casrouge, Yoann Madec, Nicolas Noël, Beatrice Jacquelin, Nicolas Huot, Darragh Duffy, Simon P Jochems, Luca Micci, Camille Lécuroux, Faroudy Boufassa, Thijs Booiman, Thalia Garcia-Tellez, Mathilde Ghislain, Roger Le Grand, Olivier Lambotte, Neeltje Kootstra, Laurence Meyer, Cecile Goujard, Mirko Paiardini, Matthew L Albert, Michaela Müller-Trutwin
INTRODUCTION: Combined anti-retroviral therapy (cART) transformed HIV-1 from a deadly disease into a chronic infection, but does not cure HIV infection. It also does not fully restore HIV-induced gut damage unless administered extremely early after infection. Additional biomarkers are needed to evaluate the capacity of therapies aimed at HIV remission/cure to restore HIV-induced intestinal immune damage and limit chronic inflammation. Herein, we aimed to identify a systemic surrogate marker whose levels would reflect gut immune damage such as intestinal Th17 cell loss starting from primary HIV-1 infection...
July 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29977959/provider-adherence-to-pre-exposure-prophylaxis-monitoring-guidelines-in-a-large-primary-care-network
#14
Matthew A Spinelli, Hyman M Scott, Eric Vittinghoff, Albert Y Liu, Alicia Morehead-Gee, Rafael Gonzalez, Susan P Buchbinder
Insufficient pre-exposure prophylaxis (PrEP) laboratory monitoring could increase HIV resistance and sexually transmitted infections. We examined test-ordering in a primary care network. Providers did not order HIV testing before almost one-quarter of PrEP initiations; panel management was associated with higher testing. Effective monitoring is needed to maximize PrEP's preventive impact.
June 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29971594/genetic-modifiers-of-radon-induced-lung-cancer-risk-a-genome-wide-interaction-study-in-former-uranium-miners
#15
Albert Rosenberger, Rayjean J Hung, David C Christiani, Neil E Caporaso, Geoffrey Liu, Stig E Bojesen, Loic Le Marchand, Ch A Haiman, Demetrios Albanes, Melinda C Aldrich, Adonina Tardon, G Fernández-Tardón, Gad Rennert, John K Field, B Kiemeney, Philip Lazarus, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Matthew B Schabath, Angeline S Andrew, Hans Brunnsstöm, Gary E Goodman, Jennifer A Doherty, Chu Chen, M Dawn Teare, H-Erich Wichmann, Judith Manz, Angela Risch, Thomas R Muley, Mikael Johansson, Paul Brennan, Maria Teresa Landi, Christopher I Amos, Beate Pesch, Georg Johnen, Thomas Brüning, Heike Bickeböller, Maria Gomolka
PURPOSE: Radon is a risk factor for lung cancer and uranium miners are more exposed than the general population. A genome-wide interaction analysis was carried out to identify genomic loci, genes or gene sets that modify the susceptibility to lung cancer given occupational exposure to the radioactive gas radon. METHODS: Samples from 28 studies provided by the International Lung Cancer Consortium were pooled with samples of former uranium miners collected by the German Federal Office of Radiation Protection...
July 3, 2018: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29967992/minimally-invasive-surgery-for-stage-iii-colon-adenocarcinoma-is-associated-with-less-delay-to-initiation-of-adjuvant-systemic-therapy-and-improved-survival
#16
Lawrence Lee, Nathalie Wong-Chong, Justin J Kelly, George J Nassif, Matthew R Albert, John R T Monson
BACKGROUND: Minimally invasive surgery (MIS) may improve surgical recovery and reduce time to adjuvant systemic therapy after colon cancer resection. The objective of this study was to determine the effect of MIS on the initiation of adjuvant systemic therapy and survival in patients with stage III colon cancer. METHODS: The 2010-2014 National Cancer Database was queried for patients with resected stage III colon adenocarcinoma, and divided into MIS, which included laparoscopic and robotic approaches, and open surgery...
July 2, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29961768/germline-cancer-susceptibility-gene-variants-somatic-second-hits-and-survival-outcomes-in-patients-with-resected-pancreatic-cancer
#17
Matthew B Yurgelun, Anu B Chittenden, Vicente Morales-Oyarvide, Douglas A Rubinson, Richard F Dunne, Margaret M Kozak, Zhi Rong Qian, Marisa W Welch, Lauren K Brais, Annacarolina Da Silva, Justin L Bui, Chen Yuan, Tingting Li, Wanwan Li, Atsuhiro Masuda, Mancang Gu, Andrea J Bullock, Daniel T Chang, Thomas E Clancy, David C Linehan, Jennifer J Findeis-Hosey, Leona A Doyle, Aaron R Thorner, Matthew D Ducar, Bruce M Wollison, Natalia Khalaf, Kimberly Perez, Sapna Syngal, Andrew J Aguirre, William C Hahn, Matthew L Meyerson, Charles S Fuchs, Shuji Ogino, Jason L Hornick, Aram F Hezel, Albert C Koong, Jonathan A Nowak, Brian M Wolpin
PURPOSE: Germline variants in double-strand DNA damage repair (dsDDR) genes (e.g., BRCA1/2) predispose to pancreatic adenocarcinoma (PDAC) and may predict sensitivity to platinum-based chemotherapy and poly(ADP) ribose polymerase (PARP) inhibitors. We sought to determine the prevalence and significance of germline cancer susceptibility gene variants in PDAC with paired somatic and survival analyses. METHODS: Using a customized next-generation sequencing panel, germline/somatic DNA was analyzed from 289 patients with resected PDAC ascertained without preselection for high-risk features (e...
July 2, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29938565/psychedelic-therapy-for-smoking-cessation-qualitative-analysis-of-participant-accounts
#18
Tehseen Noorani, Albert Garcia-Romeu, Thomas C Swift, Roland R Griffiths, Matthew W Johnson
BACKGROUND: Recent pilot trials suggest feasibility and potential efficacy of psychedelic-facilitated addiction treatment interventions. Fifteen participants completed a psilocybin-facilitated smoking cessation pilot study between 2009 and 2015. AIMS: The aims of this study were as follows: (1) to identify perceived mechanisms of change leading to smoking cessation in the pilot study; (2) to identify key themes in participant experiences and long-term outcomes to better understand the therapeutic process...
July 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29925948/altered-exocrine-function-can-drive-adipose-wasting-in-early-pancreatic-cancer
#19
Laura V Danai, Ana Babic, Michael H Rosenthal, Emily A Dennstedt, Alexander Muir, Evan C Lien, Jared R Mayers, Karen Tai, Allison N Lau, Paul Jones-Sali, Carla M Prado, Gloria M Petersen, Naoki Takahashi, Motokazu Sugimoto, Jen Jen Yeh, Nicole Lopez, Nabeel Bardeesy, Carlos Fernandez-Del Castillo, Andrew S Liss, Albert C Koong, Justin Bui, Chen Yuan, Marisa W Welch, Lauren K Brais, Matthew H Kulke, Courtney Dennis, Clary B Clish, Brian M Wolpin, Matthew G Vander Heiden
Malignancy is accompanied by changes in the metabolism of both cells and the organism1,2 . Pancreatic ductal adenocarcinoma (PDAC) is associated with wasting of peripheral tissues, a metabolic syndrome that lowers quality of life and has been proposed to decrease survival of patients with cancer3,4 . Tissue wasting is a multifactorial disease and targeting specific circulating factors to reverse this syndrome has been mostly ineffective in the clinic5,6 . Here we show that loss of both adipose and muscle tissue occurs early in the development of pancreatic cancer...
June 2018: Nature
https://www.readbyqxmd.com/read/29916871/a-multicenter-matched-comparison-of-transanal-and-robotic-total-mesorectal-excision-for-mid-and-low-rectal-adenocarcinoma
#20
Lawrence Lee, Borja de Lacy, Marcos Gomez Ruiz, Alexander Sender Liberman, Matthew R Albert, John R T Monson, Antonio Lacy, Seon Hahn Kim, Sam B Atallah
OBJECTIVE: To compare the quality of surgical resection of transanal total mesorectal excision (TA-TME) and robotic total mesorectal excision (R-TME). BACKGROUND: Both TA-TME and R-TME have been advocated to improve the quality of surgery for rectal cancer below 10 cm from the anal verge, but there are little data comparing TA-TME and R-TME. METHODS: Data of patients undergoing TA-TME or R-TME for rectal cancer below 10 cm from the anal verge and a sphincter-saving procedure from 5 high-volume rectal cancer referral centers between 2011 and 2017 were obtained...
June 18, 2018: Annals of Surgery
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