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https://www.readbyqxmd.com/read/30517875/integrated-in-vivo-quantitative-proteomics-and-nutrient-tracing-reveals-age-related-metabolic-rewiring-of-pancreatic-%C3%AE-cell-function
#1
Matthew Wortham, Jacqueline R Benthuysen, Martina Wallace, Jeffrey N Savas, Francesca Mulas, Ajit S Divakaruni, Fenfen Liu, Verena Albert, Brandon L Taylor, Yinghui Sui, Enrique Saez, Anne N Murphy, John R Yates, Christian M Metallo, Maike Sander
Pancreatic β cell physiology changes substantially throughout life, yet the mechanisms that drive these changes are poorly understood. Here, we performed comprehensive in vivo quantitative proteomic profiling of pancreatic islets from juvenile and 1-year-old mice. The analysis revealed striking differences in abundance of enzymes controlling glucose metabolism. We show that these changes in protein abundance are associated with higher activities of glucose metabolic enzymes involved in coupling factor generation as well as increased activity of the coupling factor-dependent amplifying pathway of insulin secretion...
December 4, 2018: Cell Reports
https://www.readbyqxmd.com/read/30510157/gwas-and-colocalization-analyses-implicate-carotid-intima-media-thickness-and-carotid-plaque-loci-in-cardiovascular-outcomes
#2
Nora Franceschini, Claudia Giambartolomei, Paul S de Vries, Chris Finan, Joshua C Bis, Rachael P Huntley, Ruth C Lovering, Salman M Tajuddin, Thomas W Winkler, Misa Graff, Maryam Kavousi, Caroline Dale, Albert V Smith, Edith Hofer, Elisabeth M van Leeuwen, Ilja M Nolte, Lingyi Lu, Markus Scholz, Muralidharan Sargurupremraj, Niina Pitkänen, Oscar Franzén, Peter K Joshi, Raymond Noordam, Riccardo E Marioni, Shih-Jen Hwang, Solomon K Musani, Ulf Schminke, Walter Palmas, Aaron Isaacs, Adolfo Correa, Alan B Zonderman, Albert Hofman, Alexander Teumer, Amanda J Cox, André G Uitterlinden, Andrew Wong, Andries J Smit, Anne B Newman, Annie Britton, Arno Ruusalepp, Bengt Sennblad, Bo Hedblad, Bogdan Pasaniuc, Brenda W Penninx, Carl D Langefeld, Christina L Wassel, Christophe Tzourio, Cristiano Fava, Damiano Baldassarre, Daniel H O'Leary, Daniel Teupser, Diana Kuh, Elena Tremoli, Elmo Mannarino, Enzo Grossi, Eric Boerwinkle, Eric E Schadt, Erik Ingelsson, Fabrizio Veglia, Fernando Rivadeneira, Frank Beutner, Ganesh Chauhan, Gerardo Heiss, Harold Snieder, Harry Campbell, Henry Völzke, Hugh S Markus, Ian J Deary, J Wouter Jukema, Jacqueline de Graaf, Jacqueline Price, Janne Pott, Jemma C Hopewell, Jingjing Liang, Joachim Thiery, Jorgen Engmann, Karl Gertow, Kenneth Rice, Kent D Taylor, Klodian Dhana, Lambertus A L M Kiemeney, Lars Lind, Laura M Raffield, Lenore J Launer, Lesca M Holdt, Marcus Dörr, Martin Dichgans, Matthew Traylor, Matthias Sitzer, Meena Kumari, Mika Kivimaki, Mike A Nalls, Olle Melander, Olli Raitakari, Oscar H Franco, Oscar L Rueda-Ochoa, Panos Roussos, Peter H Whincup, Philippe Amouyel, Philippe Giral, Pramod Anugu, Quenna Wong, Rainer Malik, Rainer Rauramaa, Ralph Burkhardt, Rebecca Hardy, Reinhold Schmidt, Renée de Mutsert, Richard W Morris, Rona J Strawbridge, S Goya Wannamethee, Sara Hägg, Sonia Shah, Stela McLachlan, Stella Trompet, Sudha Seshadri, Sudhir Kurl, Susan R Heckbert, Susan Ring, Tamara B Harris, Terho Lehtimäki, Tessel E Galesloot, Tina Shah, Ulf de Faire, Vincent Plagnol, Wayne D Rosamond, Wendy Post, Xiaofeng Zhu, Xiaoling Zhang, Xiuqing Guo, Yasaman Saba, Abbas Dehghan, Adrie Seldenrijk, Alanna C Morrison, Anders Hamsten, Bruce M Psaty, Cornelia M van Duijn, Deborah A Lawlor, Dennis O Mook-Kanamori, Donald W Bowden, Helena Schmidt, James F Wilson, James G Wilson, Jerome I Rotter, Joanna M Wardlaw, John Deanfield, Julian Halcox, Leo-Pekka Lyytikäinen, Markus Loeffler, Michele K Evans, Stéphanie Debette, Steve E Humphries, Uwe Völker, Vilmundur Gudnason, Aroon D Hingorani, Johan L M Björkegren, Juan P Casas, Christopher J O'Donnell
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4...
December 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/30508554/sleep-duration-and-risk-of-diabetes-observational-and-mendelian-randomization-studies
#3
Jiao Wang, Man Ki Kwok, Shiu Lun Au Yeung, Albert Martin Li, Hugh Simon Lam, June Yue Yan Leung, Lai Ling Hui, Gabriel Matthew Leung, Catherine Mary Schooling
Inadequate sleep could contribute to type 2 diabetes, but observational studies are inconsistent and open to biases, particularly from confounding. We used Mendelian randomization (MR) to obtain an unconfounded estimate of the effect of sleep duration on diabetes, fasting glucose (FG) and hemoglobin A1c (HbA1c), and an observation study to assess differences by sex. Using MR, we assessed the effects of genetically instrumented sleep on diabetes, based on 68 single nucleotide polymorphism (SNP), applied to the DIAbetes Genetics Replication and meta-analysis case (n = 26,676)-control (n = 132,532) study and on FG and HbA1c, based on 55 SNPs, applied to the Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) study of FG (n = 122,743) and HbA1c (n = 123,665)...
November 30, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/30505944/q2-longitudinal-longitudinal-and-paired-sample-analyses-of-microbiome-data
#4
Nicholas A Bokulich, Matthew R Dillon, Yilong Zhang, Jai Ram Rideout, Evan Bolyen, Huilin Li, Paul S Albert, J Gregory Caporaso
Studies of host-associated and environmental microbiomes often incorporate longitudinal sampling or paired samples in their experimental design. Longitudinal sampling provides valuable information about temporal trends and subject/population heterogeneity, offering advantages over cross-sectional and pre-post study designs. To support the needs of microbiome researchers performing longitudinal studies, we developed q2-longitudinal, a software plugin for the QIIME 2 microbiome analysis platform (https://qiime2...
November 2018: MSystems
https://www.readbyqxmd.com/read/30482938/publisher-correction-very-high-energy-particle-acceleration-powered-by-the-jets-of-the-microquasar-ss-433
#5
A U Abeysekara, A Albert, R Alfaro, C Alvarez, J D Álvarez, R Arceo, J C Arteaga-Velázquez, D Avila Rojas, H A Ayala Solares, E Belmont-Moreno, S Y BenZvi, C Brisbois, K S Caballero-Mora, T Capistrán, A Carramiñana, S Casanova, M Castillo, U Cotti, J Cotzomi, S Coutiño de León, C De León, E De la Fuente, J C Díaz-Vélez, S Dichiara, B L Dingus, M A DuVernois, R W Ellsworth, K Engel, C Espinoza, K Fang, H Fleischhack, N Fraija, A Galván-Gámez, J A García-González, F Garfias, A González-Muñoz, M M González, J A Goodman, Z Hampel-Arias, J P Harding, S Hernandez, J Hinton, B Hona, F Hueyotl-Zahuantitla, C M Hui, P Hüntemeyer, A Iriarte, A Jardin-Blicq, V Joshi, S Kaufmann, P Kar, G J Kunde, R J Lauer, W H Lee, H León Vargas, H Li, J T Linnemann, A L Longinotti, G Luis-Raya, R López-Coto, K Malone, S S Marinelli, O Martinez, I Martinez-Castellanos, J Martínez-Castro, J A Matthews, P Miranda-Romagnoli, E Moreno, M Mostafá, A Nayerhoda, L Nellen, M Newbold, M U Nisa, R Noriega-Papaqui, J Pretz, E G Pérez-Pérez, Z Ren, C D Rho, C Rivière, D Rosa-González, M Rosenberg, E Ruiz-Velasco, F Salesa Greus, A Sandoval, M Schneider, H Schoorlemmer, M Seglar Arroyo, G Sinnis, A J Smith, R W Springer, P Surajbali, I Taboada, O Tibolla, K Tollefson, I Torres, G Vianello, L Villaseñor, T Weisgarber, F Werner, S Westerhoff, J Wood, T Yapici, G Yodh, A Zepeda, H Zhang, H Zhou
In this Letter, owing to a production error, the penultimate version of the PDF was published. The HTML version was always correct. The PDF has been corrected online.
November 27, 2018: Nature
https://www.readbyqxmd.com/read/30472675/dual-suction-headway27-microcatheter-thrombectomy-for-the-treatment-of-distal-intracranial-arterial-occlusion-strokes-initial-experience-with-the-micro-adapt-technique
#6
Matthew Thomas Crockett, Timothy John Phillips, Albert Ho Yuen Chiu
BACKGROUND: Recent studies suggest that the proven benefits of endovascular thrombectomy (EVT) for the treatment of large vessel occlusion (LVO) strokes are transferable to more peripheral distal vessel occlusion (DVO) strokes under certain circumstances. Safely accessing and extracting these thrombi however remains challenging, particularly in more tortuous peripheral arteries. For such cases we have utilized the dual suction Headway27 microcatheter thrombectomy, or micro-ADAPT, technique with the aim of reducing potential trauma associated with negotiating stent retrievers or large bore aspiration catheters into the peripheral intracranial vasculature...
November 24, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/30467223/semiology-clustering-periodicity-and-natural-history-of-seizures-in-an-experimental-occipital-cortical-epilepsy-model
#7
Bao-Luen Chang, Marco Leite, Albert Snowball, Andreas Lieb, Elodie Chabrol, Matthew C Walker, Dimitri M Kullmann, Stephanie Schorge, Robert C Wykes
Focal neocortical epilepsy is a common form of epilepsy and there is a need to develop animal models that allow the evaluation of novel therapeutic strategies to treat this type of epilepsy. Tetanus toxin (TeNT) injection into rat visual cortex induces focal neocortical epilepsy without preceding status epilepticus. The latency to first seizure ranged from 3 to 7 days. Seizure duration was bimodal, with both short (approximately 30s) and long-lasting (>100s) seizures occurring in the same animals. Seizures were accompanied by non-motor features such as behavioural arrest, or motor seizures with or without evolution to generalized tonic-clonic seizures...
November 22, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/30463956/germline-genetic-polymorphisms-influence-tumor-gene-expression-and-immune-cell-infiltration
#8
Yoong Wearn Lim, Haiyin Chen-Harris, Oleg Mayba, Steve Lianoglou, Arthur Wuster, Tushar Bhangale, Zia Khan, Sanjeev Mariathasan, Anneleen Daemen, Jens Reeder, Peter M Haverty, William F Forrest, Matthew Brauer, Ira Mellman, Matthew L Albert
Cancer immunotherapy has emerged as an effective therapy in a variety of cancers. However, a key challenge in the field is that only a subset of patients who receive immunotherapy exhibit durable response. It has been hypothesized that host genetics influences the inherent immune profiles of patients and may underlie their differential response to immunotherapy. Herein, we systematically determined the association of common germline genetic variants with gene expression and immune cell infiltration of the tumor...
November 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30463411/progress-in-ligand-design-for-monolayer-protected-nanoparticles-for-nanobio-interfaces
#9
Matthew D Manning, Albert L Kwansa, Thomas Oweida, James S Peerless, Abhishek Singh, Yaroslava G Yingling
Ligand-functionalized inorganic nanoparticles, also known as monolayer-protected nanoparticles, offer great potential as vehicles for in vivo delivery of drugs, genes, and other therapeutics. These nanoparticles offer highly customizable chemistries independent of the size, shape, and functionality imparted by the inorganic core. Their success as drug delivery agents depends on their interaction with three major classes of biomolecules: nucleic acids, proteins, and membranes. Here, the authors discuss recent advances and open questions in the field of nanoparticle ligand design for nanomedicine, with a focus on atomic-scale interactions with biomolecules...
November 21, 2018: Biointerphases
https://www.readbyqxmd.com/read/30455021/reduction-of-greenhouse-gases-ghgs-and-short-lived-climate-pollutants-slcps-from-municipal-solid-waste-management-mswm-in-the-philippines-rapid-review-and-assessment
#10
Dickella Gamaralalage Jagath Premakumara, S N M Menikpura, Rajeev Kumar Singh, Matthew Hengesbaugh, Albert Altarejos Magalang, Eligio T Ildefonso, Maria Delia Cristina M Valdez, Liz C Silva
Municipal solid waste management (MSWM) is considered one of the serious environmental issues in the Philippines, with corresponding linkages to the climate change and Sustainable Development Goals (SDGs). However, methane (CH4 ) linked with indiscriminate dumping of municipal solid waste has received the much attention with regard to public health and climate change. The impacts of black carbon (BC) are less documented and understood. This paper aims to review the status of MSWM in the Philippines and makes efforts to assess the scale of short-lived climate pollutants (SLCPs), including both CH4 , and BC, associated with the country's waste sector...
October 2018: Waste Management
https://www.readbyqxmd.com/read/30428916/age-and-gender-trends-in-insecticide-treated-net-use-in-sub-saharan-africa-a-multi-country-analysis
#11
Bolanle Olapeju, Ifta Choiriyyah, Matthew Lynch, Angela Acosta, Sean Blaufuss, Eric Filemyr, Hunter Harig, April Monroe, Richmond Ato Selby, Albert Kilian, Hannah Koenker
BACKGROUND: The degree to which insecticide-treated net (ITN) supply accounts for age and gender disparities in ITN use among household members is unknown. This study explores the role of household ITN supply in the variation in ITN use among household members in sub-Saharan Africa. METHODS: Data was from Malaria Indicator Surveys or Demographic and Health Surveys collected between 2011 and 2016 from 29 countries in sub-Saharan Africa. The main outcome was ITN use the previous night...
November 14, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30418417/note-high-interest-in-doxycycline-for-sexually-transmitted-infection-post-exposure-prophylaxis-doxycycline-pep-in-a-multi-city-survey-of-men-who-have-sex-with-men-msm-using-a-social-networking-app
#12
Matthew A Spinelli, Hyman M Scott, Eric Vittinghoff, Albert Y Liu, Kenneth Coleman, Susan P Buchbinder
Current strategies to prevent sexually-transmitted infections (STI) are not controlling the epidemic. Doxycycline STI post-exposure prophylaxis' efficacy (doxycycline-PEP) shows promise in pilot studies, but wider acceptability is unknown. A majority (84%) of diverse individuals using a gay social-networking app were interested in doxycycline-PEP. Doxycycline-PEP should be examined in larger trials.
November 8, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/30411083/gamma-glutamyltransferase-reduction-is-associated-with-favorable-outcomes-in-pediatric-primary-sclerosing-cholangitis
#13
Mark R Deneau, Cara Mack, Reham Abdou, Mansi Amin, Achiya Amir, Marcus Auth, Fateh Bazerbachi, Anne Marie Broderick, Albert Chan, Matthew DiGuglielmo, Wael El-Matary, Mounif El-Youssef, Federica Ferrari, Katryn N Furuya, Frederic Gottrand, Nitika Gupta, Matjaž Homan, M K Jensen, Binita M Kamath, Kyung Mo Kim, Kaija-Leena Kolho, Anastasia Konidari, Bart Koot, Raffaele Iorio, Mercedes Martinez, Parvathi Mohan, Sirish Palle, Alexandra Papadopoulou, Amanda Ricciuto, Lawrence Saubermann, Pushpa Sathya, Eyal Shteyer, Vratislav Smolka, Atsushi Tanaka, Pamela L Valentino, Raghu Varier, Veena Venkat, Bernadette Vitola, Miriam B Vos, Marek Woynarowski, Jason Yap, Tamir Miloh
Adverse clinical events in primary sclerosing cholangitis (PSC) happen too slowly to capture during clinical trials. Surrogate endpoints are needed, but no such validated endpoints exist for children with PSC. We evaluated the association between gamma glutamyltransferase (GGT) reduction and long-term outcomes in pediatric PSC patients. We evaluated GGT normalization (< 50 IU/L) at 1 year among a multicenter cohort of children with PSC who did or did not receive treatment with ursodeoxycholic acid (UDCA)...
November 2018: Hepatology Communications
https://www.readbyqxmd.com/read/30410031/distinct-patterns-of-variation-in-the-distribution-of-knee-pain
#14
Shellie A Boudreau, Albert Cid Royo, Mark Matthews, Thomas Graven-Nielsen, Ernest N Kamavuako, Greg Slabaugh, Kristian Thorborg, Bill Vicenzino, Michael Skovdal Rathleff
The patient's expression of pain using digital-body maps expands analytic opportunities for exploring the spatial variation of bodily pain. A common knee pain condition in adolescents and adults is patellofemoral pain (PFP) and recently PFP was shown to be characterized by a heterogeneous distribution of pain. Whether there are important patterns in these distributions remains unclear. This pioneering study assesses the spatial variation of pain using principal component analysis and a clustering approach. Detailed digital-body maps of knee pain were drawn by 299 PFP patients of mixed sex, age, and pain severity...
November 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30390635/changes-in-the-liver-transcriptome-of-farmed-atlantic-salmon-salmo-salar-fed-experimental-diets-based-on-terrestrial-alternatives-to-fish-meal-and-fish-oil
#15
Albert Caballero-Solares, Xi Xue, Christopher C Parrish, Maryam Beheshti Foroutani, Richard G Taylor, Matthew L Rise
BACKGROUND: Dependence on marine natural resources threatens the sustainability of Atlantic salmon aquaculture. In the present study, Atlantic salmon fed for 14 weeks with an experimental diet based on animal by-products and vegetable oil (ABP) exhibited reduced growth performance compared with others fed a fish meal/fish oil based experimental diet (MAR) and a plant protein/vegetable oil-based experimental diet (VEG). To characterize the molecular changes underlying the differences in growth performance, we conducted a 44 K microarray study of the liver transcriptome of the three dietary groups...
November 3, 2018: BMC Genomics
https://www.readbyqxmd.com/read/30368842/quantal-risk-assessment-database-a-database-for-exploring-patterns-in-quantal-dose-response-data-in-risk-assessment-and-its-application-to-develop-priors-for-bayesian-dose-response-analysis
#16
Matthew W Wheeler, Walter W Piegorsch, Albert John Bailer
Quantitative risk assessments for physical, chemical, biological, occupational, or environmental agents rely on scientific studies to support their conclusions. These studies often include relatively few observations, and, as a result, models used to characterize the risk may include large amounts of uncertainty. The motivation, development, and assessment of new methods for risk assessment is facilitated by the availability of a set of experimental studies that span a range of dose-response patterns that are observed in practice...
October 25, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/30337273/safety-tolerability-and-preliminary-efficacy-of-an-igf-1-mimetic-in-patients-with-spinal-and-bulbar-muscular-atrophy-a-randomised-placebo-controlled-trial
#17
Christopher Grunseich, Ram Miller, Therese Swan, David J Glass, Mohamed El Mouelhi, Mara Fornaro, Olivier Petricoul, Igor Vostiar, Ronenn Roubenoff, Matthew N Meriggioli, Angela Kokkinis, Robert D Guber, Maher S Budron, John Vissing, Gianni Soraru, Tahseen Mozaffar, Albert Ludolph, John T Kissel, Kenneth H Fischbeck
BACKGROUND: Spinal and bulbar muscular atrophy is an X-linked neuromuscular disease caused by CAG repeat expansion in the androgen receptor gene. Patients with this disease have low concentrations of insulin-like growth factor-1 (IGF-1), and studies of overexpression and administration of IGF-1 showed benefit in a transgenic model; thus the IGF-1 pathway presents as a potential treatment target. We assessed safety, tolerability, and preliminary efficacy of BVS857, an IGF-1 mimetic, in patients with spinal and bulbar muscular atrophy...
October 15, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30332405/peripherally-derived-macrophages-modulate-microglial-function-to-reduce-inflammation-after-cns-injury
#18
Andrew D Greenhalgh, Juan G Zarruk, Luke M Healy, Sam J Baskar Jesudasan, Priya Jhelum, Christopher K Salmon, Albert Formanek, Matthew V Russo, Jack P Antel, Dorian B McGavern, Barry W McColl, Samuel David
Infiltrating monocyte-derived macrophages (MDMs) and resident microglia dominate central nervous system (CNS) injury sites. Differential roles for these cell populations after injury are beginning to be uncovered. Here, we show evidence that MDMs and microglia directly communicate with one another and differentially modulate each other's functions. Importantly, microglia-mediated phagocytosis and inflammation are suppressed by infiltrating macrophages. In the context of spinal cord injury (SCI), preventing such communication increases microglial activation and worsens functional recovery...
October 2018: PLoS Biology
https://www.readbyqxmd.com/read/30326855/prior-ct-imaging-history-for-patients-who-undergo-whole-body-ct-for-acute-traumatic-injury-and-are-discharged-home-from-the-emergency-department
#19
Mary Matthews, Peter Richman, Scott Krall, Kimberly Leeson, K Tom Xu, Albert L Gest, Osbert Blow
BACKGROUND: Recurrent CT imaging is believed to significantly increase lifetime malignancy risk. We previously reported that high acuity, admitted trauma patients who received a whole-body CT in the emergency department (ED) had a history of prior CT imaging in 14% of cases. The primary objective of this study was to determine the CT imaging history for trauma patients who received a whole-body CT but were ultimately deemed safe for discharge directly home from the ED. METHODS: This was a retrospective cohort study conducted at an academic ED...
October 16, 2018: BMC Emergency Medicine
https://www.readbyqxmd.com/read/30323087/nccn-guidelines-insights-small-cell-lung-cancer-version-2-2018
#20
Gregory P Kalemkerian, Billy W Loo, Wallace Akerley, Albert Attia, Michael Bassetti, Yanis Boumber, Roy Decker, M Chris Dobelbower, Afshin Dowlati, Robert J Downey, Charles Florsheim, Apar Kishor P Ganti, John C Grecula, Matthew A Gubens, Christine L Hann, James A Hayman, Rebecca Suk Heist, Marianna Koczywas, Robert E Merritt, Nisha Mohindra, Julian Molina, Cesar A Moran, Daniel Morgensztern, Saraswati Pokharel, David C Portnoy, Deborah Rhodes, Chad Rusthoven, Rafael Santana-Davila, Charles C Williams, Karin G Hoffmann, Miranda Hughes
The NCCN Guidelines for Small Cell Lung Cancer (SCLC) address all aspects of disease management. These NCCN Guidelines Insights focus on recent updates to the NCCN Guidelines for SCLC regarding immunotherapy, systemic therapy, and radiation therapy. For the 2018 update, new sections were added on "Signs and Symptoms of SCLC" and "Principles of Pathologic Review."
October 2018: Journal of the National Comprehensive Cancer Network: JNCCN
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