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https://www.readbyqxmd.com/read/30341961/randomized-controlled-multicenter-study-comparing-short-dental-implants-6mm-versus-longer-dental-implants-11-15mm-in-combination-with-sinus-floor-elevation-procedures-5-year-data
#1
Daniel S Thoma, Robert Haas, Katarzyna Sporniak-Tutak, Abel Garcia, Thomas D Taylor, Christoph H F Hämmerle
AIM: to compare the implant survival rate between short dental implants and standard length implants placed in combination with bone grafting at 5 years of loading. METHODS: This multicenter study enrolled 101 patients (137 implants) with a posterior maxillary bone height of 5-7mm. Patients randomly received either short implants (6mm) (GS) or long implants (11-15mm) with sinus grafting (GG). Six months later, implants were loaded with single crowns and patients re-examined at one, three and five years of loading...
October 20, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/30337529/substantiating-freedom-from-parasitic-infection-by-combining-transmission-model-predictions-with-disease-surveys
#2
Edwin Michael, Morgan E Smith, Moses N Katabarwa, Edson Byamukama, Emily Grisworld, Peace Habomugisha, Thomson Lakwo, Edridah Tukahebwa, Emmanuel S Miri, Abel Eigege, Evelyn Ngige, Thomas R Unnasch, Frank O Richards
Stopping interventions is a critical decision for parasite elimination programmes. Quantifying the probability that elimination has occurred due to interventions can be facilitated by combining infection status information from parasitological surveys with extinction thresholds predicted by parasite transmission models. Here we demonstrate how the integrated use of these two pieces of information derived from infection monitoring data can be used to develop an analytic framework for guiding the making of defensible decisions to stop interventions...
October 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/30326297/opioid-use-and-potency-are-associated-with-clinical-features-quality-of-life-and-use-of-resources-in-patients-with-gastroparesis
#3
William L Hasler, Laura A Wilson, Linda A Nguyen, William J Snape, Thomas L Abell, Kenneth L Koch, Richard W McCallum, Pankaj J Pasricha, Irene Sarosiek, Gianrico Farrugia, Madhusudan Grover, Linda A Lee, Laura Miriel, James Tonascia, Frank A Hamilton, Henry P Parkman
BACKGROUND & AIMS: Many patients with gastroparesis are prescribed opioids for pain control, but indications for opioid prescription and relations of opioid use to gastroparesis manifestations are undefined. We characterized associations of use of potent vs weaker opioids and presentations of diabetic and idiopathic gastroparesis. METHODS: We collected data on symptoms, gastric emptying, quality of life, and healthcare resource use from 583 patients with gastroparesis (more than 10% 4 hr scintigraphic retention) from the NIDDK Gastroparesis Consortium, from January 2007 through November 2016...
October 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30312708/upregulated-p-rex1-exacerbates-human-airway-smooth-muscle-hyperplasia-in-asthma
#4
Yapei Huang, Yan Xie, Haihong Jiang, Peter W Abel, Reynold A Panettieri, Thomas B Casale, Yaping Tu
P-Rex1, a Rac-selective activator is aberrantly upregulated in airway smooth muscle of subjects with asthma compared to non-asthmatics, and augments cell proliferation, thus contributing to airway smooth muscle hyperplasia and remodeling in severe asthma.
October 9, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30283855/differences-in-referral-access-to-care-between-gastrointestinal-subspecialty-patients-barriers-and-opportunities
#5
Kartika Reddy, Caitlyn Patrick, Hammad Liaquat, Edmundo Rodriquez, Abigail Stocker, Barbra Cave, Matt C Cave, Laura Smart, Teresa Cutts, Thomas Abell
Purpose: Referral access to subspecialty care for patients with gastrointestinal (GI) diseases is not well defined, but has significant importance to patients. We hypothesized that patients experience barriers to care in two common gastroenterology subspecialties, Hepatology and Motility, in a university medical center. Methods: Two hundred thirteen clinic patients (mean age 46.5 years; 66.5% female; 85.6% Caucasians) completed a formatted questionnaire on access to care. Hepatology patients were older (49...
2018: Health Equity
https://www.readbyqxmd.com/read/30209345/objective-evaluation-of-multiple-sclerosis-lesion-segmentation-using-a-data-management-and-processing-infrastructure
#6
Olivier Commowick, Audrey Istace, Michaël Kain, Baptiste Laurent, Florent Leray, Mathieu Simon, Sorina Camarasu Pop, Pascal Girard, Roxana Améli, Jean-Christophe Ferré, Anne Kerbrat, Thomas Tourdias, Frédéric Cervenansky, Tristan Glatard, Jérémy Beaumont, Senan Doyle, Florence Forbes, Jesse Knight, April Khademi, Amirreza Mahbod, Chunliang Wang, Richard McKinley, Franca Wagner, John Muschelli, Elizabeth Sweeney, Eloy Roura, Xavier Lladó, Michel M Santos, Wellington P Santos, Abel G Silva-Filho, Xavier Tomas-Fernandez, Hélène Urien, Isabelle Bloch, Sergi Valverde, Mariano Cabezas, Francisco Javier Vera-Olmos, Norberto Malpica, Charles Guttmann, Sandra Vukusic, Gilles Edan, Michel Dojat, Martin Styner, Simon K Warfield, François Cotton, Christian Barillot
We present a study of multiple sclerosis segmentation algorithms conducted at the international MICCAI 2016 challenge. This challenge was operated using a new open-science computing infrastructure. This allowed for the automatic and independent evaluation of a large range of algorithms in a fair and completely automatic manner. This computing infrastructure was used to evaluate thirteen methods of MS lesions segmentation, exploring a broad range of state-of-theart algorithms, against a high-quality database of 53 MS cases coming from four centers following a common definition of the acquisition protocol...
September 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30159405/predicting-resistance-of-clinical-abl-mutations-to-targeted-kinase-inhibitors-using-alchemical-free-energy-calculations
#7
Kevin Hauser, Christopher Negron, Steven K Albanese, Soumya Ray, Thomas Steinbrecher, Robert Abel, John D Chodera, Lingle Wang
The therapeutic effect of targeted kinase inhibitors can be significantly reduced by intrinsic or acquired resistance mutations that modulate the affinity of the drug for the kinase. In cancer, the majority of missense mutations are rare, making it difficult to predict their impact on inhibitor affinity. This complicates the practice of precision medicine, pairing of patients with clinical trials, and development of next-generation inhibitors. Here, we examine the potential for alchemical free-energy calculations to predict how kinase mutations modulate inhibitor affinities to Abl, a major target in chronic myelogenous leukemia (CML)...
2018: Communications biology
https://www.readbyqxmd.com/read/30139841/patient-clinician-discordance-in-perceptions-of-treatment-risks-and-benefits-in-older-patients-with-acute-myeloid-leukemia
#8
Areej El-Jawahri, Margaret Nelson-Lowe, Harry VanDusen, Lara Traeger, Gregory A Abel, Joseph A Greer, Amir Fathi, David P Steensma, Thomas W LeBlanc, Zhigang Li, Daniel DeAngelo, Martha Wadleigh, Gabriela Hobbs, Julia Foster, Andrew Brunner, Philip Amrein, Richard M Stone, Jennifer S Temel
BACKGROUND: Older patients (≥60 years) with acute myeloid leukemia (AML) face difficult decisions regarding treatment with "intensive" chemotherapy that carries significant toxicity for a small chance of a cure versus "nonintensive" chemotherapy to control the disease, but with fewer side effects. However, studies of how these patients understand the risks and benefits of such treatments are lacking. METHODS: We conducted a longitudinal study of older patients newly diagnosed with AML assessing patients' ( n = 100) and oncologists' ( n = 11) perceptions of treatment-related mortality at enrollment and prognosis at 1 month...
August 23, 2018: Oncologist
https://www.readbyqxmd.com/read/30124903/a-case-study-evaluating-the-portability-of-an-executable-computable-phenotype-algorithm-across-multiple-institutions-and-electronic-health-record-environments
#9
Jennifer A Pacheco, Luke V Rasmussen, Richard C Kiefer, Thomas R Campion, Peter Speltz, Robert J Carroll, Sarah C Stallings, Huan Mo, Monika Ahuja, Guoqian Jiang, Eric R LaRose, Peggy L Peissig, Ning Shang, Barbara Benoit, Vivian S Gainer, Kenneth Borthwick, Kathryn L Jackson, Ambrish Sharma, Andy Yizhou Wu, Abel N Kho, Dan M Roden, Jyotishman Pathak, Joshua C Denny, William K Thompson
Electronic health record (EHR) algorithms for defining patient cohorts are commonly shared as free-text descriptions that require human intervention both to interpret and implement. We developed the Phenotype Execution and Modeling Architecture (PhEMA, http://projectphema.org) to author and execute standardized computable phenotype algorithms. With PhEMA, we converted an algorithm for benign prostatic hyperplasia, developed for the electronic Medical Records and Genomics network (eMERGE), into a standards-based computable format...
August 16, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/30086739/duration-of-incapacity-of-work-after-tibial-plateau-fracture-is-affected-by-work-intensity
#10
Tobias M Kraus, Charlotte Abele, Thomas Freude, Atesch Ateschrang, Ulrich Stöckle, Fabian M Stuby, Steffen Schröter
BACKGROUND: Tibial plateau fractures requiring surgery are severe injuries of the lower extremity. Tibial plateau fractures have an impact not only on physically demanding jobs but notably on general professional life too. The aim of this study was to assess how the professional activity of patients will be affected after a tibial plateau fracture. METHODS: 39 consecutive patients (ages 20-61 years) were retrospectively included in the study and were clinically examined at a minimum of 14 month postoperatively...
August 7, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30086735/transcriptomic-signatures-reveal-immune-dysregulation-in-human-diabetic-and-idiopathic-gastroparesis
#11
Madhusudan Grover, Simon J Gibbons, Asha A Nair, Cheryl E Bernard, Adeel S Zubair, Seth T Eisenman, Laura A Wilson, Laura Miriel, Pankaj J Pasricha, Henry P Parkman, Irene Sarosiek, Richard W McCallum, Kenneth L Koch, Thomas L Abell, William J Snape, Braden Kuo, Robert J Shulman, Travis J McKenzie, Todd A Kellogg, Michael L Kendrick, James Tonascia, Frank A Hamilton, Gianrico Farrugia
BACKGROUND: Cellular changes described in human gastroparesis have revealed a role for immune dysregulation, however, a mechanistic understanding of human gastroparesis and the signaling pathways involved are still unclear. METHODS: Diabetic gastroparetics, diabetic non-gastroparetic controls, idiopathic gastroparetics and non-diabetic non-gastroparetic controls underwent full-thickness gastric body biopsies. Deep RNA sequencing was performed and pathway analysis of differentially expressed transcripts was done using Ingenuity®...
August 7, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/30072895/risperidone-provides-better-improvement-of-sleep-disturbances-than-haloperidol-therapy-in-schizophrenia-patients-with-cannabis-positive-urinalysis
#12
Peta-Gaye L Thomas-Brown, Jacqueline S Martin, Clayton A Sewell, Wendel D Abel, Maxine D Gossell-Williams
A high percentage of persons with Schizophrenia also uses Cannabis and this may potentially alter the therapeutic benefits of the antipsychotic medications prescribed. The aim of this study was to assess the impact of Cannabis usage on antipsychotic therapy of sleep disturbances in schizophrenia subjects. Male subjects, ≥18 years, admitted to the University Hospital of the West Indies psychiatric ward between October 2015 and October 2016, and diagnosed with schizophrenia were recruited for the study. Following written informed consent to the study, subjects were prescribed either risperidone monotherapy or haloperidol monotherapy orally for 14 days and classified as Cannabis users (CU) or non-users (non-CU), with presence/absence of Cannabis metabolite in urine samples...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30072435/incomplete-penetrance-for-isolated-congenital-asplenia-in-humans-with-mutations-in-translated-and-untranslated-rpsa-exons
#13
Alexandre Bolze, Bertrand Boisson, Barbara Bosch, Alexander Antipenko, Matthieu Bouaziz, Paul Sackstein, Malik Chaker-Margot, Vincent Barlogis, Tracy Briggs, Elena Colino, Aurora C Elmore, Alain Fischer, Ferah Genel, Angela Hewlett, Maher Jedidi, Jadranka Kelecic, Renate Krüger, Cheng-Lung Ku, Dinakantha Kumararatne, Alain Lefevre-Utile, Sam Loughlin, Nizar Mahlaoui, Susanne Markus, Juan-Miguel Garcia, Mathilde Nizon, Matias Oleastro, Malgorzata Pac, Capucine Picard, Andrew J Pollard, Carlos Rodriguez-Gallego, Caroline Thomas, Horst Von Bernuth, Austen Worth, Isabelle Meyts, Maurizio Risolino, Licia Selleri, Anne Puel, Sebastian Klinge, Laurent Abel, Jean-Laurent Casanova
Isolated congenital asplenia (ICA) is the only known human developmental defect exclusively affecting a lymphoid organ. In 2013, we showed that private deleterious mutations in the protein-coding region of RPSA , encoding ribosomal protein SA, caused ICA by haploinsufficiency with complete penetrance. We reported seven heterozygous protein-coding mutations in 8 of the 23 kindreds studied, including 6 of the 8 multiplex kindreds. We have since enrolled 33 new kindreds, 5 of which are multiplex. We describe here 11 new heterozygous ICA-causing RPSA protein-coding mutations, and the first two mutations in the 5'-UTR of this gene, which disrupt mRNA splicing...
August 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30049701/determinants-of-adherence-and-consequences-of-the-transition-from-adolescence-to-adulthood-among-young-people-with-severe-haemophilia-transhemo-study-protocol-for-a-multicentric-french-national-observational-cross-sectional-study
#14
Noémie Resseguier, Natacha Rosso-Delsemme, Any Beltran Anzola, Karine Baumstarck, Vanessa Milien, Laurent Ardillon, Sophie Bayart, Claire Berger, Marie-Anne Bertrand, Christine Biron-Andreani, Annie Borel-Derlon, Sabine Castet, Pierre Chamouni, Ségolène Claeyssens Donadel, Emmanuelle De Raucourt, Dominique Desprez, Céline Falaise, Birgit Frotscher, Valérie Gay, Jenny Goudemand, Yves Gruel, Benoît Guillet, Annie Harroche, Abel Hassoun, Yoann Huguenin, Thierry Lambert, Aurélien Lebreton, Anne Lienhart, Michèle Martin, Sandrine Meunier, Fabrice Monpoux, Guillaume Mourey, Claude Negrier, Philippe Nguyen, Placide Nyombe, Caroline Oudot, Brigitte Pan-Petesch, Benoît Polack, Anne Rafowicz, Antoine Rauch, Delphine Rivaud, Pascale Schneider, Alexandra Spiegel, Cecile Stoven, Brigitte Tardy, Marc Trossaërt, Jean-Baptiste Valentin, Stéphane Vanderbecken, Fabienne Volot, Annelise Voyer-Ebrard, Bénédicte Wibaut, Tanguy Leroy, Thomas Sannie, Hervé Chambost, Pascal Auquier
INTRODUCTION: Severe haemophilia is a rare disease characterised by spontaneous bleeding from early childhood, which may lead to various complications, especially in joints. It is nowadays possible to avoid these complications thanks to substitutive therapies for which the issue of adherence is major. The transition from adolescence to adulthood in young people with severe haemophilia is a critical period as it is associated with a high risk of lack of adherence to healthcare, which might have serious consequences on daily activities and on quality of life...
July 25, 2018: BMJ Open
https://www.readbyqxmd.com/read/30034599/pk-pd-disconnect-observed-with-a-reversible-endothelial-lipase-inhibitor
#15
Jon J Hangeland, Lynn M Abell, Leonard P Adam, Ji Jiang, Todd J Friends, Lauren E Haque, James Neels, Joelle M Onorato, Alice Ye A Chen, David S Taylor, Xiaohong Yin, Thomas W Harrity, Michael D Basso, Richard Yang, Paul G Sleph, David A Gordon, Christine S Huang, Ruth R Wexler, Heather J Finlay, R Michael Lawrence
Screening of a small set of nonselective lipase inhibitors against endothelial lipase (EL) identified a potent and reversible inhibitor, N -(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide ( 5 ; EL IC50 = 61 nM, ELHDL IC50 = 454 nM). Deck mining identified a related hit, N -(3-(3,4-dichlorophenyl)propyl)-4-hydroxy-1-methyl-5-oxo-2,5-dihydro-1 H -pyrrole-3-carboxamide ( 6a ; EL IC50 = 41 nM, ELHDL IC50 = 1760 nM). Both compounds were selective against lipoprotein lipase (LPL) but nonselective versus hepatic lipase (HL)...
July 12, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/30016141/a-purpose-designed-monofilament-fibre-pad-for-debridement-of-hard-to-reach-wounds-experience-in-clinical-practice
#16
MULTICENTER STUDY
Joachim Dissemond, Thomas Eberlein, Anke Bültemann, Gunnar Riepe, Ingo Stoffels, Jackie Stephen-Haynes, Claas Roes, Martin Abel
OBJECTIVE: Effective and comfortable debridement is an important part of managing complex wounds. This user test evaluated a monofilament-fibre pad (with handle) (Debrisoft Lolly, Lohmann & Rauscher GmbH & Co. KG) in the debridement of various hard-to-reach wounds. METHOD: The multicentre, international user test was performed by experienced physicians and nurses in Germany and the UK, who used the monofilament-fibre pad in their clinical practice. After debridement, using the monofilament-fibre pad, the clinicians completed an evaluation questionnaire...
July 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/30015804/systematic-continental-scale-temporal-monitoring-of-marine-pelagic-microbiota-by-the-australian-marine-microbial-biodiversity-initiative
#17
Mark V Brown, Jodie van de Kamp, Martin Ostrowski, Justin R Seymour, Tim Ingleton, Lauren F Messer, Thomas Jeffries, Nahshon Siboni, Bonnie Laverock, Jaume Bibiloni-Isaksson, Tiffanie M Nelson, Frank Coman, Claire H Davies, Dion Frampton, Mark Rayner, Kirianne Goossen, Stan Robert, Bronwyn Holmes, Guy C J Abell, Pascal Craw, Tim Kahlke, Swan Li San Sow, Kirsty McAllister, Jonathan Windsor, Michele Skuza, Ryan Crossing, Nicole Patten, Paul Malthouse, Paul D van Ruth, Ian Paulsen, Jed A Fuhrman, Anthony Richardson, Jason Koval, Andrew Bissett, Anna Fitzgerald, Tim Moltmann, Levente Bodrossy
Sustained observations of microbial dynamics are rare, especially in southern hemisphere waters. The Australian Marine Microbial Biodiversity Initiative (AMMBI) provides methodologically standardized, continental scale, temporal phylogenetic amplicon sequencing data describing Bacteria, Archaea and microbial Eukarya assemblages. Sequence data is linked to extensive physical, biological and chemical oceanographic contextual information. Samples are collected monthly to seasonally from multiple depths at seven sites: Darwin Harbour (Northern Territory), Yongala (Queensland), North Stradbroke Island (Queensland), Port Hacking (New South Wales), Maria Island (Tasmania), Kangaroo Island (South Australia), Rottnest Island (Western Australia)...
July 17, 2018: Scientific Data
https://www.readbyqxmd.com/read/30007944/hypoventilation-disproportionate-to-osas-severity-in-children-with-prader-willi-syndrome
#18
Francois Abel, Hui-Leng Tan, Valentina Negro, Nicola Bridges, Thomas Carlisle, Elaine Chan, Aidan Laverty, Michael Miligkos, Martin Samuels, Athanasios G Kaditis
OBJECTIVE: To test the hypothesis that children with Prader-Willi syndrome (PWS) and obstructive sleep apnoea syndrome (OSAS) have hypercapnia for higher proportion of total sleep time (TST) than non-syndromic children with similar obstructive apnoea-hypopnoea index (OAHI). DESIGN: Cross-sectional study. SETTING: Two tertiary care hospitals. PATIENTS: Patients with PWS and non-syndromic children with snoring who underwent polygraphy and were of similar age, body mass index (BMI) z-score and OAHI...
July 14, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29961125/predictors-of-early-progression-of-surgically-treated-atypical-meningiomas
#19
Karol P Budohoski, James Clerkin, Christopher P Millward, Philip J O'Halloran, Mueez Waqar, Seamus Looby, Adam M H Young, Mathew R Guilfoyle, Diana Fitzroll, Abel Devadass, Kieren Allinson, Michael Farrell, Mohsen Javadpour, Michael D Jenkinson, Thomas Santarius, Ramez W Kirollos
BACKGROUND: Clinical behaviour of atypical meningiomas is not uniform. While, as a group, they exhibit a high recurrence rate, some pursue a more benign course, whereas others progress early. We aim to investigate the imaging and pathological factors that predict risk of early tumour progression and to determine whether early progression is related to outcome. METHODS: Adult patients with WHO grade II meningioma treated in three regional referral centres between 2007 and 2014 were included...
September 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29934758/diabetic-gastroparesis-principles-and-current-trends-in-management
#20
REVIEW
Sathya Krishnasamy, Thomas L Abell
This article is a comprehensive review of diabetic gastroparesis, defined as delayed or disordered gastric emptying, including basic principles and current trends in management. This review includes sections on anatomy and physiology, diagnosis and differential diagnosis as well as management and current guidelines for treatment of diabetic gastroparesis. Diabetic gastroparesis (DGp) is a component of autonomic neuropathy resulting from long-standing poorly controlled type 1 and type 2 diabetes. The diagnostic workup of DGp first excludes obstruction and other causes including medications that may mimic delayed/disordered gastric emptying...
June 22, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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