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https://www.readbyqxmd.com/read/30525253/the-effect-of-gastric-electrical-stimulation-on-small-bowel-motility-in-patients-with-gastroparesis-and-concomitant-pancreatic-and-small-bowel-dysfunction-from-animal-model-to-human-application
#1
Patrick McKenzie, Abigail Stocker, Peng Du, Christopher Lahr, Leo K Cheng, Lindsay McElmurray, Archana Kedar, Benjamin Boatright, Hamza Hassan, Michael Hughes, Endashaw Omer, Bikash Bhandari, Thomas L Abell
BACKGROUND/AIMS: Patients with gastroparesis often have biliary/pancreatic and small bowel symptoms but the effects of gastric electrical stimulation on small bowel electrical activity of the mid-gut have not been studied. Animal model aim: Establish gastric and upper small bowel/biliary slow wave activity relationships with electrical stimulation. Human study aim: Demonstrate improvement in symptoms associated with proximal small bowel dysmotility in gastric stimulated patients. MATERIALS AND METHODS: Animal model: In vivo evoked responses of duodenal and Sphincter of Oddi measures recorded during gastric electrical stimulation in a nonsurvival swine model (N = 3)...
December 7, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/30510260/honey-bee-royalactin-unlocks-conserved-pluripotency-pathway-in-mammals
#2
Derrick C Wan, Stefanie L Morgan, Andrew L Spencley, Natasha Mariano, Erin Y Chang, Gautam Shankar, Yunhai Luo, Ted H Li, Dana Huh, Star K Huynh, Jasmine M Garcia, Cole M Dovey, Jennifer Lumb, Ling Liu, Katharine V Brown, Abel Bermudez, Richard Luong, Hong Zeng, Victoria L Mascetti, Sharon J Pitteri, Jordon Wang, Hua Tu, Marco Quarta, Vittorio Sebastiano, Roel Nusse, Thomas A Rando, Jan E Carette, J Fernando Bazan, Kevin C Wang
Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through its major protein component Royalactin, royal jelly can maintain pluripotency by activating a ground-state pluripotency-like gene network. We further identify Regina, a mammalian structural analog of Royalactin that also induces a naive-like state in mouse embryonic stem cells...
December 4, 2018: Nature Communications
https://www.readbyqxmd.com/read/30487585/author-correction-differential-expression-pattern-of-co-inhibitory-molecules-on-cd4-t-cells-in-uncomplicated-versus-complicated-malaria
#3
Annemieke Abel, Christiane Steeg, Francis Aminkiah, Otchere Addai-Mensah, Marylyn Addo, Nicola Gagliani, Christian Casar, Denis Dekugmen Yar, Ellis Owusu-Dabo, Thomas Jacobs, Maria Sophia Mackroth
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
November 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30467042/systematic-review-of-the-role-of-cytoreductive-nephrectomy-in-the-targeted-therapy-era-and-beyond-an-individualized-approach-to-metastatic-renal-cell-carcinoma
#4
REVIEW
Bimal Bhindi, E Jason Abel, Laurence Albiges, Karim Bensalah, Stephen A Boorjian, Siamak Daneshmand, Jose A Karam, Ross J Mason, Thomas Powles, Axel Bex
CONTEXT: The role of cytoreductive nephrectomy (CN) in the management of metastatic renal cell carcinoma (mRCC) in the targeted therapy (TT) era is controversial. OBJECTIVE: To assess if CN versus no CN is associated with improved overall survival (OS) in patients with mRCC treated in the TT era and beyond, characterize the morbidity of CN, identify prognostic and predictive factors, and evaluate outcomes following treatment sequencing. EVIDENCE ACQUISITION: Medline, EMBASE, and Cochrane databases were searched from inception to June 4, 2018 for English-language clinical trials, cohort studies, and case-control studies evaluating patients with mRCC who underwent and those who did not undergo CN...
October 25, 2018: European Urology
https://www.readbyqxmd.com/read/30451847/author-correction-substantiating-freedom-from-parasitic-infection-by-combining-transmission-model-predictions-with-disease-surveys
#5
Edwin Michael, Morgan E Smith, Moses N Katabarwa, Edson Byamukama, Emily Griswold, Peace Habomugisha, Thomson Lakwo, Edridah Tukahebwa, Emmanuel S Miri, Abel Eigege, Evelyn Ngige, Thomas R Unnasch, Frank O Richards
The original version of this Article contained an error in the spelling of Emily Griswold, which was incorrectly given as Emily Grisworld. This error has now been corrected in both the PDF and HTML versions of the Article.
November 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/30439392/functional-and-immunogenic-characterization-of-diverse-hcv-glycoprotein-e2-variants
#6
Tanvi Khera, Patrick Behrendt, Dorothea Bankwitz, Richard J P Brown, Daniel Todt, Mandy Doepke, Abdul Ghafoor Khan, Kai Schulze, John Law, Michael Logan, Darren Hockman, Jason Alexander Ji-Xhin Wong, Leona Dold, Victor Gonzalez-Motos, Ulrich Spengler, Abel Viejo-Borbolla, Luisa Ströh, Thomas Krey, Alexander W Tarr, Eike Steinmann, Michael P Manns, Florian Klein, Carlos A Guzman, Joseph Marcotrigiano, Michael Houghton, Thomas Pietschmann
BACKGROUND AND AIMS: Induction of cross-reactive antibodies targeting conserved epitopes of the envelope proteins E1E2 is a key requirement for an HCV vaccine. Conserved epitopes like the viral CD81-binding site are targeted by rare broadly neutralizing antibodies. However, these viral segments are occluded by variable regions and glycans. We aimed to identify antigens exposing conserved epitopes and to characterize their immunogenicity. METHODS: We created HCV variants with mutated glycosylation sites and/or hypervariable region 1 (HVR1)...
November 12, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30406962/compositional-response-of-amazon-forests-to-climate-change
#7
Adriane Esquivel-Muelbert, Timothy R Baker, Kyle G Dexter, Simon L Lewis, Roel J W Brienen, Ted R Feldpausch, Jon Lloyd, Abel Monteagudo-Mendoza, Luzmila Arroyo, Esteban Álvarez-Dávila, Niro Higuchi, Beatriz S Marimon, Ben Hur Marimon-Junior, Marcos Silveira, Emilio Vilanova, Emanuel Gloor, Yadvinder Malhi, Jerôme Chave, Jos Barlow, Damien Bonal, Nallaret Davila Cardozo, Terry Erwin, Sophie Fauset, Bruno Hérault, Susan Laurance, Lourens Poorter, Lan Qie, Clement Stahl, Martin J P Sullivan, Hans Ter Steege, Vincent Antoine Vos, Pieter A Zuidema, Everton Almeida, Edmar Almeida de Oliveira, Ana Andrade, Simone Aparecida Vieira, Luiz Aragão, Alejandro Araujo-Murakami, Eric Arets, Gerardo A Aymard C, Plínio Barbosa Camargo, Jorcely G Barroso, Frans Bongers, Rene Boot, José Luís Camargo, Wendeson Castro, Victor Chama Moscoso, James Comiskey, Fernando Cornejo Valverde, Antonio Carlos Lola da Costa, Jhon Del Aguila Pasquel, Tony Di Fiore, Luisa Fernanda Duque, Fernando Elias, Julien Engel, Gerardo Flores Llampazo, David Galbraith, Rafael Herrera Fernández, Eurídice Honorio Coronado, Wannes Hubau, Eliana Jimenez-Rojas, Adriano José Nogueira Lima, Ricardo Keichi Umetsu, William Laurance, Gabriela Lopez-Gonzalez, Thomas Lovejoy, Omar Aurelio Melo Cruz, Paulo S Morandi, David Neill, Percy Núñez Vargas, Nadir C Pallqui, Alexander Parada Gutierrez, Guido Pardo, Julie Peacock, Marielos Peña-Claros, Maria Cristina Peñuela-Mora, Pascal Petronelli, Georgia C Pickavance, Nigel Pitman, Adriana Prieto, Carlos Quesada, Hirma Ramírez-Angulo, Maxime Réjou-Méchain, Zorayda Restrepo Correa, Anand Roopsind, Agustín Rudas, Rafael Salomão, Natalino Silva, Javier Silva Espejo, James Singh, Juliana Stropp, John Terborgh, Raquel Thomas, Marisol Toledo, Armando Torres-Lezama, Luis Valenzuela Gamarra, Peter J van de Meer, Geertje van der Heijden, Peter van der Hout, Rodolfo Vasquez Martinez, Cesar Vela, Ima Célia Guimarães Vieira, Oliver L Phillips
Most of the planet's diversity is concentrated in the tropics, which includes many regions undergoing rapid climate change. Yet, while climate-induced biodiversity changes are widely documented elsewhere, few studies have addressed this issue for lowland tropical ecosystems. Here we investigate whether the floristic and functional composition of intact lowland Amazonian forests have been changing by evaluating records from 106 long-term inventory plots spanning 30 years. We analyse three traits that have been hypothesized to respond to different environmental drivers (increase in moisture stress and atmospheric CO2 concentrations): maximum tree size, biogeographic water-deficit affiliation and wood density...
November 8, 2018: Global Change Biology
https://www.readbyqxmd.com/read/30404771/dual-use-of-a-patient-portal-and-clinical-video-telehealth-by-veterans-with-mental-health-diagnoses-retrospective-cross-sectional-analysis
#8
Erica A Abel, Stephanie L Shimada, Karen Wang, Christine Ramsey, Melissa Skanderson, Joseph Erdos, Linda Godleski, Thomas K Houston, Cynthia A Brandt
BACKGROUND: Access to mental health care is challenging. The Veterans Health Administration (VHA) has been addressing these challenges through technological innovations including the implementation of Clinical Video Telehealth, two-way interactive and synchronous videoconferencing between a provider and a patient, and an electronic patient portal and personal health record, My HealtheVet. OBJECTIVE: This study aimed to describe early adoption and use of My HealtheVet and Clinical Video Telehealth among VHA users with mental health diagnoses...
November 7, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/30404035/ethnic-racial-and-sex-differences-in-etiology-symptoms-treatment-and-symptom-outcomes-of-patients-with-gastroparesis
#9
Henry P Parkman, Goro Yamada, Mark L Van Natta, Katherine Yates, William L Hasler, Irene Sarosiek, Madhusudan Grover, Ron Schey, Thomas L Abell, Kenneth L Koch, Braden Kuo, John Clarke, Gianrico Farrugia, Linda Nguyen, William J Snape, Laura Miriel, James Tonascia, Frank Hamilton, Pankaj J Pasricha, Richard W McCallum
BACKGROUND & AIMS: Gastroparesis is a chronic disorder of the stomach characterized by nausea, vomiting, early satiety, postprandial fullness, and abdominal pain. There is limited information on gastroparesis in minority populations. We assessed ethnic, racial, and sex variations in the etiology, symptoms, quality of life, gastric emptying, treatments, and symptom outcomes of patients with gastroparesis. METHODS: We collected information from the National Institutes of Health Gastroparesis Consortium on 718 adult patients, from September 2007 through December 2017...
November 4, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30396529/gastric-electrical-stimulator-for-treatment-of-gastroparesis
#10
REVIEW
Hadi Atassi, Thomas L Abell
Patients with gastroparesis sometimes suffer from intractable nausea and vomiting, abdominal pain, and bloating, as well as a host of other symptoms that can often be difficult to control. Initially, patients are treated conservatively; some do well with conservative management but unfortunately some do not. Over the years, studies have shown the benefits of gastric electrical stimulation, which often results in symptomatic improvement and improvement in gastric emptying times. This article discusses the history of gastric electrical stimulation and its use in clinical practice to help those suffering from gastroparesis that is refractory to conservative medical management...
January 2019: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/30344806/efficacy-of-gastric-electrical-stimulation-for-gastroparesis-us-european-comparison
#11
Jordan Burlen, Matt Runnels, Minesh Mehta, Stina Andersson, Philippe Ducrotte, Guillaume Gourcerol, Greger Lindberg, Greg Fullarton, Hasse Abrahamsson, Amar Al-Juburi, Chris Lahr, Hani Rashed, Thomas Abell
Background: Gastric electrical stimulation (GES) is used in both the US and Europe, but little research has investigated the demographics of gastroparesis patients receiving GES by geographic location. Methods: We compared data from 380 patients, 296 female and 84 males, mean age 42 years, 246 idiopathic (ID), 107 diabetic (DM), and 27 post-surgical (PS). The statistical significance was calculated by Chi-square test and a P-value obtained for ID, DM, and PS. The statistical significance was calculated by Fischer exact test and a P-value obtained comparing male vs...
October 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/30342719/clinical-efficacy-of-serum-derived-bovine-immunoglobulin-in-patients-with-refractory-inflammatory-bowel-disease
#12
Hammad Liaquat, Munish Ashat, Abigail Stocker, Lindsay McElmurray, Karen Beatty, Thomas L Abell, Gerald Dryden
BACKGROUND: Inflammatory bowel disease (IBD) can have autoimmunity and/or intestinal barrier dysfunction as part of pathophysiology and may be refractory to all available treatment options. Serum-derived bovine immunoglobulin (SBI) binds microbial components with postulated downstream effects of normalized gut immune and barrier function, which may be useful for managing IBD. The purpose of our study was to evaluate the effectiveness of SBI in the management of refractory IBD, particularly symptoms of chronic diarrhea and loose stools...
December 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30341961/randomized-controlled-multicenter-study-comparing-short-dental-implants-6mm-versus-longer-dental-implants-11-15mm-in-combination-with-sinus-floor-elevation-procedures-5-year-data
#13
Daniel S Thoma, Robert Haas, Katarzyna Sporniak-Tutak, Abel Garcia, Thomas D Taylor, Christoph H F Hämmerle
AIM: to compare the implant survival rate between short dental implants and standard length implants placed in combination with bone grafting at 5 years of loading. METHODS: This multicenter study enrolled 101 patients (137 implants) with a posterior maxillary bone height of 5-7mm. Patients randomly received either short implants (6mm) (GS) or long implants (11-15mm) with sinus grafting (GG). Six months later, implants were loaded with single crowns and patients re-examined at one, three and five years of loading...
October 20, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/30337529/substantiating-freedom-from-parasitic-infection-by-combining-transmission-model-predictions-with-disease-surveys
#14
Edwin Michael, Morgan E Smith, Moses N Katabarwa, Edson Byamukama, Emily Grisworld, Peace Habomugisha, Thomson Lakwo, Edridah Tukahebwa, Emmanuel S Miri, Abel Eigege, Evelyn Ngige, Thomas R Unnasch, Frank O Richards
Stopping interventions is a critical decision for parasite elimination programmes. Quantifying the probability that elimination has occurred due to interventions can be facilitated by combining infection status information from parasitological surveys with extinction thresholds predicted by parasite transmission models. Here we demonstrate how the integrated use of these two pieces of information derived from infection monitoring data can be used to develop an analytic framework for guiding the making of defensible decisions to stop interventions...
October 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/30326297/opioid-use-and-potency-are-associated-with-clinical-features-quality-of-life-and-use-of-resources-in-patients-with-gastroparesis
#15
William L Hasler, Laura A Wilson, Linda A Nguyen, William J Snape, Thomas L Abell, Kenneth L Koch, Richard W McCallum, Pankaj J Pasricha, Irene Sarosiek, Gianrico Farrugia, Madhusudan Grover, Linda A Lee, Laura Miriel, James Tonascia, Frank A Hamilton, Henry P Parkman
BACKGROUND & AIMS: Many patients with gastroparesis are prescribed opioids for pain control, but indications for opioid prescription and relations of opioid use to gastroparesis manifestations are undefined. We characterized associations of use of potent vs weaker opioids and presentations of diabetic and idiopathic gastroparesis. METHODS: We collected data on symptoms, gastric emptying, quality of life, and healthcare resource use from 583 patients with gastroparesis (more than 10% 4 hr scintigraphic retention) from the NIDDK Gastroparesis Consortium, from January 2007 through November 2016...
October 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30312708/upregulated-p-rex1-exacerbates-human-airway-smooth-muscle-hyperplasia-in-asthma
#16
Yapei Huang, Yan Xie, Haihong Jiang, Peter W Abel, Reynold A Panettieri, Thomas B Casale, Yaping Tu
No abstract text is available yet for this article.
October 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30283855/differences-in-referral-access-to-care-between-gastrointestinal-subspecialty-patients-barriers-and-opportunities
#17
Kartika Reddy, Caitlyn Patrick, Hammad Liaquat, Edmundo Rodriquez, Abigail Stocker, Barbra Cave, Matt C Cave, Laura Smart, Teresa Cutts, Thomas Abell
Purpose: Referral access to subspecialty care for patients with gastrointestinal (GI) diseases is not well defined, but has significant importance to patients. We hypothesized that patients experience barriers to care in two common gastroenterology subspecialties, Hepatology and Motility, in a university medical center. Methods: Two hundred thirteen clinic patients (mean age 46.5 years; 66.5% female; 85.6% Caucasians) completed a formatted questionnaire on access to care. Hepatology patients were older (49...
2018: Health equity
https://www.readbyqxmd.com/read/30209345/objective-evaluation-of-multiple-sclerosis-lesion-segmentation-using-a-data-management-and-processing-infrastructure
#18
Olivier Commowick, Audrey Istace, Michaël Kain, Baptiste Laurent, Florent Leray, Mathieu Simon, Sorina Camarasu Pop, Pascal Girard, Roxana Améli, Jean-Christophe Ferré, Anne Kerbrat, Thomas Tourdias, Frédéric Cervenansky, Tristan Glatard, Jérémy Beaumont, Senan Doyle, Florence Forbes, Jesse Knight, April Khademi, Amirreza Mahbod, Chunliang Wang, Richard McKinley, Franca Wagner, John Muschelli, Elizabeth Sweeney, Eloy Roura, Xavier Lladó, Michel M Santos, Wellington P Santos, Abel G Silva-Filho, Xavier Tomas-Fernandez, Hélène Urien, Isabelle Bloch, Sergi Valverde, Mariano Cabezas, Francisco Javier Vera-Olmos, Norberto Malpica, Charles Guttmann, Sandra Vukusic, Gilles Edan, Michel Dojat, Martin Styner, Simon K Warfield, François Cotton, Christian Barillot
We present a study of multiple sclerosis segmentation algorithms conducted at the international MICCAI 2016 challenge. This challenge was operated using a new open-science computing infrastructure. This allowed for the automatic and independent evaluation of a large range of algorithms in a fair and completely automatic manner. This computing infrastructure was used to evaluate thirteen methods of MS lesions segmentation, exploring a broad range of state-of-theart algorithms, against a high-quality database of 53 MS cases coming from four centers following a common definition of the acquisition protocol...
September 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30159405/predicting-resistance-of-clinical-abl-mutations-to-targeted-kinase-inhibitors-using-alchemical-free-energy-calculations
#19
Kevin Hauser, Christopher Negron, Steven K Albanese, Soumya Ray, Thomas Steinbrecher, Robert Abel, John D Chodera, Lingle Wang
The therapeutic effect of targeted kinase inhibitors can be significantly reduced by intrinsic or acquired resistance mutations that modulate the affinity of the drug for the kinase. In cancer, the majority of missense mutations are rare, making it difficult to predict their impact on inhibitor affinity. This complicates the practice of precision medicine, pairing of patients with clinical trials, and development of next-generation inhibitors. Here, we examine the potential for alchemical free-energy calculations to predict how kinase mutations modulate inhibitor affinities to Abl, a major target in chronic myelogenous leukemia (CML)...
2018: Communications biology
https://www.readbyqxmd.com/read/30139841/patient-clinician-discordance-in-perceptions-of-treatment-risks-and-benefits-in-older-patients-with-acute-myeloid-leukemia
#20
Areej El-Jawahri, Margaret Nelson-Lowe, Harry VanDusen, Lara Traeger, Gregory A Abel, Joseph A Greer, Amir Fathi, David P Steensma, Thomas W LeBlanc, Zhigang Li, Daniel DeAngelo, Martha Wadleigh, Gabriela Hobbs, Julia Foster, Andrew Brunner, Philip Amrein, Richard M Stone, Jennifer S Temel
BACKGROUND: Older patients (≥60 years) with acute myeloid leukemia (AML) face difficult decisions regarding treatment with "intensive" chemotherapy that carries significant toxicity for a small chance of a cure versus "nonintensive" chemotherapy to control the disease, but with fewer side effects. However, studies of how these patients understand the risks and benefits of such treatments are lacking. METHODS: We conducted a longitudinal study of older patients newly diagnosed with AML assessing patients' ( n = 100) and oncologists' ( n = 11) perceptions of treatment-related mortality at enrollment and prognosis at 1 month...
August 23, 2018: Oncologist
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