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https://www.readbyqxmd.com/read/30086739/duration-of-incapacity-of-work-after-tibial-plateau-fracture-is-affected-by-work-intensity
#1
Tobias M Kraus, Charlotte Abele, Thomas Freude, Atesch Ateschrang, Ulrich Stöckle, Fabian M Stuby, Steffen Schröter
BACKGROUND: Tibial plateau fractures requiring surgery are severe injuries of the lower extremity. Tibial plateau fractures have an impact not only on physically demanding jobs but notably on general professional life too. The aim of this study was to assess how the professional activity of patients will be affected after a tibial plateau fracture. METHODS: 39 consecutive patients (ages 20-61 years) were retrospectively included in the study and were clinically examined at a minimum of 14 month postoperatively...
August 7, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30086735/transcriptomic-signatures-reveal-immune-dysregulation-in-human-diabetic-and-idiopathic-gastroparesis
#2
Madhusudan Grover, Simon J Gibbons, Asha A Nair, Cheryl E Bernard, Adeel S Zubair, Seth T Eisenman, Laura A Wilson, Laura Miriel, Pankaj J Pasricha, Henry P Parkman, Irene Sarosiek, Richard W McCallum, Kenneth L Koch, Thomas L Abell, William J Snape, Braden Kuo, Robert J Shulman, Travis J McKenzie, Todd A Kellogg, Michael L Kendrick, James Tonascia, Frank A Hamilton, Gianrico Farrugia
BACKGROUND: Cellular changes described in human gastroparesis have revealed a role for immune dysregulation, however, a mechanistic understanding of human gastroparesis and the signaling pathways involved are still unclear. METHODS: Diabetic gastroparetics, diabetic non-gastroparetic controls, idiopathic gastroparetics and non-diabetic non-gastroparetic controls underwent full-thickness gastric body biopsies. Deep RNA sequencing was performed and pathway analysis of differentially expressed transcripts was done using Ingenuity®...
August 7, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/30072895/risperidone-provides-better-improvement-of-sleep-disturbances-than-haloperidol-therapy-in-schizophrenia-patients-with-cannabis-positive-urinalysis
#3
Peta-Gaye L Thomas-Brown, Jacqueline S Martin, Clayton A Sewell, Wendel D Abel, Maxine D Gossell-Williams
A high percentage of persons with Schizophrenia also uses Cannabis and this may potentially alter the therapeutic benefits of the antipsychotic medications prescribed. The aim of this study was to assess the impact of Cannabis usage on antipsychotic therapy of sleep disturbances in schizophrenia subjects. Male subjects, ≥18 years, admitted to the University Hospital of the West Indies psychiatric ward between October 2015 and October 2016, and diagnosed with schizophrenia were recruited for the study. Following written informed consent to the study, subjects were prescribed either risperidone monotherapy or haloperidol monotherapy orally for 14 days and classified as Cannabis users (CU) or non-users (non-CU), with presence/absence of Cannabis metabolite in urine samples...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30072435/incomplete-penetrance-for-isolated-congenital-asplenia-in-humans-with-mutations-in-translated-and-untranslated-rpsa-exons
#4
Alexandre Bolze, Bertrand Boisson, Barbara Bosch, Alexander Antipenko, Matthieu Bouaziz, Paul Sackstein, Malik Chaker-Margot, Vincent Barlogis, Tracy Briggs, Elena Colino, Aurora C Elmore, Alain Fischer, Ferah Genel, Angela Hewlett, Maher Jedidi, Jadranka Kelecic, Renate Krüger, Cheng-Lung Ku, Dinakantha Kumararatne, Alain Lefevre-Utile, Sam Loughlin, Nizar Mahlaoui, Susanne Markus, Juan-Miguel Garcia, Mathilde Nizon, Matias Oleastro, Malgorzata Pac, Capucine Picard, Andrew J Pollard, Carlos Rodriguez-Gallego, Caroline Thomas, Horst Von Bernuth, Austen Worth, Isabelle Meyts, Maurizio Risolino, Licia Selleri, Anne Puel, Sebastian Klinge, Laurent Abel, Jean-Laurent Casanova
Isolated congenital asplenia (ICA) is the only known human developmental defect exclusively affecting a lymphoid organ. In 2013, we showed that private deleterious mutations in the protein-coding region of RPSA , encoding ribosomal protein SA, caused ICA by haploinsufficiency with complete penetrance. We reported seven heterozygous protein-coding mutations in 8 of the 23 kindreds studied, including 6 of the 8 multiplex kindreds. We have since enrolled 33 new kindreds, 5 of which are multiplex. We describe here 11 new heterozygous ICA-causing RPSA protein-coding mutations, and the first two mutations in the 5'-UTR of this gene, which disrupt mRNA splicing...
August 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30049701/determinants-of-adherence-and-consequences-of-the-transition-from-adolescence-to-adulthood-among-young-people-with-severe-haemophilia-transhemo-study-protocol-for-a-multicentric-french-national-observational-cross-sectional-study
#5
Noémie Resseguier, Natacha Rosso-Delsemme, Any Beltran Anzola, Karine Baumstarck, Vanessa Milien, Laurent Ardillon, Sophie Bayart, Claire Berger, Marie-Anne Bertrand, Christine Biron-Andreani, Annie Borel-Derlon, Sabine Castet, Pierre Chamouni, Ségolène Claeyssens Donadel, Emmanuelle De Raucourt, Dominique Desprez, Céline Falaise, Birgit Frotscher, Valérie Gay, Jenny Goudemand, Yves Gruel, Benoît Guillet, Annie Harroche, Abel Hassoun, Yoann Huguenin, Thierry Lambert, Aurélien Lebreton, Anne Lienhart, Michèle Martin, Sandrine Meunier, Fabrice Monpoux, Guillaume Mourey, Claude Negrier, Philippe Nguyen, Placide Nyombe, Caroline Oudot, Brigitte Pan-Petesch, Benoît Polack, Anne Rafowicz, Antoine Rauch, Delphine Rivaud, Pascale Schneider, Alexandra Spiegel, Cecile Stoven, Brigitte Tardy, Marc Trossaërt, Jean-Baptiste Valentin, Stéphane Vanderbecken, Fabienne Volot, Annelise Voyer-Ebrard, Bénédicte Wibaut, Tanguy Leroy, Thomas Sannie, Hervé Chambost, Pascal Auquier
INTRODUCTION: Severe haemophilia is a rare disease characterised by spontaneous bleeding from early childhood, which may lead to various complications, especially in joints. It is nowadays possible to avoid these complications thanks to substitutive therapies for which the issue of adherence is major. The transition from adolescence to adulthood in young people with severe haemophilia is a critical period as it is associated with a high risk of lack of adherence to healthcare, which might have serious consequences on daily activities and on quality of life...
July 25, 2018: BMJ Open
https://www.readbyqxmd.com/read/30034599/pk-pd-disconnect-observed-with-a-reversible-endothelial-lipase-inhibitor
#6
Jon J Hangeland, Lynn M Abell, Leonard P Adam, Ji Jiang, Todd J Friends, Lauren E Haque, James Neels, Joelle M Onorato, Alice Ye A Chen, David S Taylor, Xiaohong Yin, Thomas W Harrity, Michael D Basso, Richard Yang, Paul G Sleph, David A Gordon, Christine S Huang, Ruth R Wexler, Heather J Finlay, R Michael Lawrence
Screening of a small set of nonselective lipase inhibitors against endothelial lipase (EL) identified a potent and reversible inhibitor, N -(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide ( 5 ; EL IC50 = 61 nM, ELHDL IC50 = 454 nM). Deck mining identified a related hit, N -(3-(3,4-dichlorophenyl)propyl)-4-hydroxy-1-methyl-5-oxo-2,5-dihydro-1 H -pyrrole-3-carboxamide ( 6a ; EL IC50 = 41 nM, ELHDL IC50 = 1760 nM). Both compounds were selective against lipoprotein lipase (LPL) but nonselective versus hepatic lipase (HL)...
July 12, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/30016141/a-purpose-designed-monofilament-fibre-pad-for-debridement-of-hard-to-reach-wounds-experience-in-clinical-practice
#7
Joachim Dissemond, Thomas Eberlein, Anke Bültemann, Gunnar Riepe, Ingo Stoffels, Jackie Stephen-Haynes, Claas Roes, Martin Abel
OBJECTIVE: Effective and comfortable debridement is an important part of managing complex wounds. This user test evaluated a monofilament-fibre pad (with handle) (Debrisoft Lolly, Lohmann & Rauscher GmbH & Co. KG) in the debridement of various hard-to-reach wounds. METHOD: The multicentre, international user test was performed by experienced physicians and nurses in Germany and the UK, who used the monofilament-fibre pad in their clinical practice. After debridement, using the monofilament-fibre pad, the clinicians completed an evaluation questionnaire...
July 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/30015804/systematic-continental-scale-temporal-monitoring-of-marine-pelagic-microbiota-by-the-australian-marine-microbial-biodiversity-initiative
#8
Mark V Brown, Jodie van de Kamp, Martin Ostrowski, Justin R Seymour, Tim Ingleton, Lauren F Messer, Thomas Jeffries, Nahshon Siboni, Bonnie Laverock, Jaume Bibiloni-Isaksson, Tiffanie M Nelson, Frank Coman, Claire H Davies, Dion Frampton, Mark Rayner, Kirianne Goossen, Stan Robert, Bronwyn Holmes, Guy C J Abell, Pascal Craw, Tim Kahlke, Swan Li San Sow, Kirsty McAllister, Jonathan Windsor, Michele Skuza, Ryan Crossing, Nicole Patten, Paul Malthouse, Paul D van Ruth, Ian Paulsen, Jed A Fuhrman, Anthony Richardson, Jason Koval, Andrew Bissett, Anna Fitzgerald, Tim Moltmann, Levente Bodrossy
Sustained observations of microbial dynamics are rare, especially in southern hemisphere waters. The Australian Marine Microbial Biodiversity Initiative (AMMBI) provides methodologically standardized, continental scale, temporal phylogenetic amplicon sequencing data describing Bacteria, Archaea and microbial Eukarya assemblages. Sequence data is linked to extensive physical, biological and chemical oceanographic contextual information. Samples are collected monthly to seasonally from multiple depths at seven sites: Darwin Harbour (Northern Territory), Yongala (Queensland), North Stradbroke Island (Queensland), Port Hacking (New South Wales), Maria Island (Tasmania), Kangaroo Island (South Australia), Rottnest Island (Western Australia)...
July 17, 2018: Scientific Data
https://www.readbyqxmd.com/read/30007944/hypoventilation-disproportionate-to-osas-severity-in-children-with-prader-willi-syndrome
#9
Francois Abel, Hui-Leng Tan, Valentina Negro, Nicola Bridges, Thomas Carlisle, Elaine Chan, Aidan Laverty, Michael Miligkos, Martin Samuels, Athanasios G Kaditis
OBJECTIVE: To test the hypothesis that children with Prader-Willi syndrome (PWS) and obstructive sleep apnoea syndrome (OSAS) have hypercapnia for higher proportion of total sleep time (TST) than non-syndromic children with similar obstructive apnoea-hypopnoea index (OAHI). DESIGN: Cross-sectional study. SETTING: Two tertiary care hospitals. PATIENTS: Patients with PWS and non-syndromic children with snoring who underwent polygraphy and were of similar age, body mass index (BMI) z-score and OAHI...
July 14, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29961125/predictors-of-early-progression-of-surgically-treated-atypical-meningiomas
#10
Karol P Budohoski, James Clerkin, Christopher P Millward, Philip J O'Halloran, Mueez Waqar, Seamus Looby, Adam M H Young, Mathew R Guilfoyle, Diana Fitzroll, Abel Devadass, Kieren Allinson, Michael Farrell, Mohsen Javadpour, Michael D Jenkinson, Thomas Santarius, Ramez W Kirollos
BACKGROUND: Clinical behaviour of atypical meningiomas is not uniform. While, as a group, they exhibit a high recurrence rate, some pursue a more benign course, whereas others progress early. We aim to investigate the imaging and pathological factors that predict risk of early tumour progression and to determine whether early progression is related to outcome. METHODS: Adult patients with WHO grade II meningioma treated in three regional referral centres between 2007 and 2014 were included...
June 30, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29934758/diabetic-gastroparesis-principles-and-current-trends-in-management
#11
REVIEW
Sathya Krishnasamy, Thomas L Abell
This article is a comprehensive review of diabetic gastroparesis, defined as delayed or disordered gastric emptying, including basic principles and current trends in management. This review includes sections on anatomy and physiology, diagnosis and differential diagnosis as well as management and current guidelines for treatment of diabetic gastroparesis. Diabetic gastroparesis (DGp) is a component of autonomic neuropathy resulting from long-standing poorly controlled type 1 and type 2 diabetes. The diagnostic workup of DGp first excludes obstruction and other causes including medications that may mimic delayed/disordered gastric emptying...
June 22, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29916475/endoscopic-aspects-of-temporary-gastric-electrical-stimulator-lead-placement-in-patients-with-gastroparesis-and-gastroparesis-like-syndromes
#12
Gregg Wendorf, Minesh Mehta, Abigail Stocker, Justin Smith, Thomas Abell
No abstract text is available yet for this article.
April 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29844452/linking-spatial-gene-expression-patterns-to-sex-specific-brain-structural-changes-on-a-mouse-model-of-16p11-2-hemideletion
#13
Vinod Jangir Kumar, Nicola M Grissom, Sarah E McKee, Hannah Schoch, Nicole Bowman, Robbert Havekes, Manoj Kumar, Stephen Pickup, Harish Poptani, Teresa M Reyes, Mike Hawrylycz, Ted Abel, Thomas Nickl-Jockschat
Neurodevelopmental disorders, such as ASD and ADHD, affect males about three to four times more often than females. 16p11.2 hemideletion is a copy number variation that is highly associated with neurodevelopmental disorders. Previous work from our lab has shown that a mouse model of 16p11.2 hemideletion (del/+) exhibits male-specific behavioral phenotypes. We, therefore, aimed to investigate with magnetic resonance imaging (MRI), whether del/+ animals also exhibited a sex-specific neuroanatomical endophenotype...
May 29, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29804215/texture-analysis-of-small-renal-cell-carcinomas-at-mdct-for-predicting-relevant-histologic-and-protein-biomarkers
#14
Andrew T Scrima, Meghan G Lubner, E Jason Abel, Thomas C Havighurst, Daniel D Shapiro, Wei Huang, Perry J Pickhardt
PURPOSE: To assess CT texture features of small renal cell carcinomas (≤ 4cm) for association with key pathologic features including protein biomarkers. METHODS: Quantitative CT texture analysis (CTTA) of small renal cancers (≤ 4cm) was performed on non-contrast and portal venous phase abdominal MDCT scans with an ROI drawn at the largest cross-sectional diameter of the tumor using commercially available software. Texture parameters including mean pixel attenuation, the standard deviation (SD) of the pixel distribution histogram, entropy, the mean of positive pixels, the skewness (i...
May 26, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29789065/towards-a-synthetic-mitochondrion
#15
Olivier Biner, Thomas Schick, Aymar Abel Ganguin, Christoph von Ballmoos
Our group at the University of Bern uses biochemical and biophysical techniques to unravel details of the molecular mechanism of membrane proteins. Of special interest are the large multi-subunit complexes of the universally conserved respiratory chain and the ATP synthase that are found in mitochondria and aerobic bacteria. In a bottom-up approach using purified membrane proteins and synthetic lipids, we aim to mimic the basic processes of oxidative phosphorylation. We further develop methodologies to increase the complexity of such artificial systems, paving the way for a synthetic mitochondrion...
May 30, 2018: Chimia
https://www.readbyqxmd.com/read/29725756/lactate-kinetics-in-handcycling-under-various-exercise-modalities-and-their-relationship-to-performance-measures-in-able-bodied-participants
#16
Oliver J Quittmann, Thomas Abel, Sebastian Zeller, Tina Foitschik, Heiko K Strüder
PURPOSE: The aim of this study was to expand exercise testing in handcycling by (1) examining different approaches to determine lactate kinetics in handcycling under various exercise modalities and (2) identifying relationships between parameters of lactate kinetics and selected performance measures. METHODS: Twelve able-bodied nationally competitive triathletes performed a familiarisation, a sprint test, an incremental step test, and a continuous load trial at a power output corresponding to a lactate concentration (La) of 4 mmol l-1 (PO4 ) in a racing handcycle that was mounted on an ergometer...
July 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29672439/cajal-cell-counts-are-important-predictors-of-outcomes-in-drug-refractory-gastroparesis-patients-with-neurostimulation
#17
Endashaw Omer, Archana Kedar, Harsha S Nagarajarao, Yana Nikitina, Vetta Vedanarayanan, Charu Subramony, Christopher J Lahr, Thomas L Abell
BACKGROUND AND AIMS: Cajal cells serve as the pacemaker cells of the gastrointestinal tract and regulates peristalsis. On the baisis of that fact, it has been hypothesized that a decrease in Cajal cells can lead to gastroparesis and other motility issues. Treatment with medications has a limited efficacy and most resort to gastric electrical stimulation (GES) devices for symptomatic relief. We believe that the number of Cajal cells present is directly proportional to symptomatic relief with GES...
April 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29652893/glucose-sensor-augmented-continuous-subcutaneous-insulin-infusion-in-patients-with-diabetic-gastroparesis-an-open-label-pilot-prospective-study
#18
Jorge Calles-Escandón, Kenneth L Koch, William L Hasler, Mark L Van Natta, Pankaj J Pasricha, James Tonascia, Henry P Parkman, Frank Hamilton, William H Herman, Marina Basina, Bruce Buckingham, Karen Earle, Kjersti Kirkeby, Kristen Hairston, Tamis Bright, Amy E Rothberg, Andrew T Kraftson, Elias S Siraj, Angela Subauste, Linda A Lee, Thomas L Abell, Richard W McCallum, Irene Sarosiek, Linda Nguyen, Ronnie Fass, William J Snape, Ivana A Vaughn, Laura A Miriel, Gianrico Farrugia
Erratic blood glucose levels can be a cause and consequence of delayed gastric emptying in patients with diabetes. It is unknown if better glycemic control increases risks of hypoglycemia or improves hemoglobin A1c levels and gastrointestinal symptoms in diabetic gastroparesis. This study investigated the safety and potential efficacy of continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) in poorly controlled diabetes with gastroparesis. Forty-five type 1 or 2 patients with diabetes and gastroparesis and hemoglobin A1c >8% from the NIDDK Gastroparesis Consortium enrolled in a 24 week open-label pilot prospective study of CSII plus CGM...
2018: PloS One
https://www.readbyqxmd.com/read/29555909/differential-expression-pattern-of-co-inhibitory-molecules-on-cd4-t-cells-in-uncomplicated-versus-complicated-malaria
#19
Annemieke Abel, Christiane Steeg, Francis Aminkiah, Otchere Addai-Mensah, Marylyn Addo, Nicola Gagliani, Christian Casar, Denis Dekugmen Yar, Ellis Owusu-Dabo, Thomas Jacobs, Maria Sophia Mackroth
The immune response of malaria patients is a main factor influencing the clinical severity of malaria. A tight regulation of the CD4+ T cell response or the induction of tolerance have been proposed to contribute to protection from severe or clinical disease. We therefore compared the CD4+ T cell phenotypes of Ghanaian children with complicated malaria, uncomplicated malaria, asymptomatic Plasmodium falciparum (Pf) infection or no infection. Using flow cytometric analysis and automated multivariate clustering, we characterized the expression of the co-inhibitory molecules CTLA-4, PD-1, Tim-3, and LAG-3 and other molecules implicated in regulatory function on CD4+ T cells...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29527406/a-retrospective-database-analysis-of-neonatal-morbidities-to-evaluate-a-composite-endpoint-for-use-in-preterm-labor-clinical-trials
#20
Jeanne M Pimenta, Myla Ebeling, Timothy H Montague, Kathleen J Beach, Jill Abell, Michael T O'Shea, Marcy Powell, Thomas C Hulsey
Objective  To propose and assess a composite endpoint (CE) of neonatal benefit based on neonatal mortality and morbidities by gestational age (GA) for use in preterm labor clinical trials. Study Design  A descriptive, retrospective analysis of the Medical University of South Carolina Perinatal Information System database was conducted. Neonatal morbidities were assessed for inclusion in the CE based on clinical significance/risk of childhood neurodevelopmental impairment, frequency, and association with GA in a mother-neonate linked cohort, comprising women with uncomplicated singleton pregnancies delivered at ≥24 weeks' GA...
January 2018: American Journal of Perinatology Reports
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