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breast cancer and lncRNA

Zhiping Cai, Yapei Wu, Yao Li, Jizhong Ren, Linhui Wang
Long non-coding RNAs (lncRNAs) have been found essential for tumorigenesis of prostate cancer (PC), but its role in the regulation of castration-resistant prostate cancer (CRPC) is poorly identified. Here, we showed that a lncRNA, Breast-Cancer Anti-Estrogen Resistance 4 (BCAR4), which plays a pivotal role in the tamoxifen-resistance of breast cancer, was significantly upregulated in CRPC, but not in castration-sensitive prostate cancer (CSPC), compared to normal prostate tissue. High BCAR4 levels in CRPC were correlated with poor patients' overall survival...
December 4, 2018: Aging
Kun Liang, Ying Yang, Dingjun Zha, Bo Yue, Jianhua Qiu, Changming Zhang
Long noncoding RNAs (lncRNA) snaR is a characterized oncogenic lncRNA in triple negative breast cancer and ovarian cancer, while its role in other human diseases is unknown. In the present study, we found that plasma levels of snaR were upregulated in patients with laryngeal squamous cell carcinoma (LSCC) than in healthy controls. Plasma levels of snaR increased with increase in AJCC stages. Follow-up study showed that high plasma levels of snaR were correlated with poor overall survival. Plasma levels of snaR were positively correlated with transforming growth factor beta (TGF-β1) in patients with LSCC but not in healthy controls...
December 2, 2018: Journal of Cellular Biochemistry
Kaiming Zhang, Peng Liu, Hailin Tang, Xiaoming Xie, Yanan Kong, Cailu Song, Xingsheng Qiu, Xiangsheng Xiao
Long non-coding RNA (LncRNA) actin filament-associated protein1-antisense RNA 1 (AFAP1-AS1) is overexpressed in various types of cancers and plays an important role in tumor progression and prognosis. This study investigates the role of AFAP1-AS1 in tumor progression in triple-negative breast cancer (TNBC). We found that AFAP1-AS1 was overexpressed in TNBC tissues and cells. Overexpression of LncRNA AFAP1-AS1 was associated with poor prognosis in TNBC patients. Moreover, we demonstrated that upregulation of AFAP1-AS1 promoted cell proliferation and invasion, and inhibited cell apoptosis in vitro , while overexpression of AFAP1-AS1 promoted tumor growth in vivo ...
2018: Frontiers in Pharmacology
Ching-Ching Yeh, Jun-Liang Luo, Nam Nhut Phan, Yi-Chun Cheng, Lu-Ping Chow, Mong-Hsun Tsai, Eric Y Chuang, Liang-Chuan Lai
Hypoxia plays a crucial role in the aggressiveness of solid tumors by driving multiple signaling pathways. Recently, long non-coding RNA (lncRNA) has been reported to promote or inhibit tumor aggressiveness by regulating gene expression. Previous studies in our laboratory found that the lncRNA NDRG1-OT1 is significantly up-regulated under hypoxia and inhibits its target gene NDRG1 at both the mRNA and protein levels. At the protein level, NDRG1-OT1 increases NDRG1 degradation via ubiquitin-mediated proteolysis...
November 30, 2018: RNA Biology
Mahdieh Jadaliha, Omid Gholamalamdari, Wei Tang, Yang Zhang, Ana Petracovici, Qinyu Hao, Aamira Tariq, Tae Gyoon Kim, Sarah E Holton, Deepak K Singh, Xiao Ling Li, Susan M Freier, Stefan Ambs, Rohit Bhargava, Ashish Lal, Supriya G Prasanth, Jian Ma, Kannanganattu V Prasanth
The human genome encodes thousands of long noncoding RNA (lncRNA) genes; the function of majority of them is poorly understood. Aberrant expression of a significant number of lncRNAs is observed in various diseases, including cancer. To gain insights into the role of lncRNAs in breast cancer progression, we performed genome-wide transcriptome analyses in an isogenic, triple negative breast cancer (TNBC/basal-like) progression cell lines using a 3D cell culture model. We identified significantly altered expression of 1853 lncRNAs, including ~500 natural antisense transcript (NATs) lncRNAs...
November 29, 2018: PLoS Genetics
Safa Abdollahzadeh, Saeid Ghorbian
BACKGROUND: The H19 is a maternally expressed imprinted gene transcribing a long noncoding RNA (lncRNA), which has previously been reported to be involved in tumorigenesis and cancer progression. The aim of this study was to evaluate the associations between two lncRNA-H19 (rs3741219 T>C and rs217727 C>T) gene polymorphisms with the risk of breast cancer (BC). METHODS: In a case-control investigation, we evaluated 150 BC patients and 100 cancer-free subjects in East Azerbaijan Province of Iran...
November 28, 2018: Journal of Clinical Laboratory Analysis
Jia Li, Ruijuan Liu, Shifeng Tang, Fubin Feng, Xue Wang, Lingyu Qi, Cun Liu, Yan Yao, Changgang Sun
Recent studies have shown that long noncoding RNAs (lncRNA) HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility. The greatest threat to women's health among a variety of cancers is breast cancer (BC), cervical cancer (CC), and ovarian cancer (OC), and the incidence of it is increasing. We performed a meta-analysis to clarify the relationship between lncRNA HOTAIR expression and BC, CC, and OC susceptibility. We thoroughly searched PubMed, Embase, and the Cochrane Library to obtain the relevant literature...
November 28, 2018: Journal of Cellular Biochemistry
Yuedong Zhang, Hongwei Zhang, Huiqing Kang, Wenjie Huo, Yu Zhou, Yuchao Zhang
The upregulation of long non‑coding RNA (lncRNA) human ovarian cancer‑specific transcript 2 (HOST2) has been identified in breast cancer. The present study aimed to investigate whether lncRNA HOST2 regulated the proliferation of triple negative breast cancer (TNBC) cells, and the underlying molecular mechanism. In total, 30 patients with primary TNBC, who were treated at Wuhai People's Hospital (Wuhai, China), were recruited for the present study. Reverse transcription‑quantitative polymerase chain reaction analysis was used for the examination of gene expression levels...
November 26, 2018: International Journal of Molecular Medicine
Guanming Lu, Yueyong Li, Yanfei Ma, Jinlan Lu, Yongcheng Chen, Qiulan Jiang, Qiang Qin, Lifeng Zhao, Qianfang Huang, Zhizhai Luo, Shiqing Huang, Zhongheng Wei
BACKGROUND: Emerging evidence have illustrated the vital role of long noncoding RNAs (lncRNAs) long intergenic non-protein coding RNA 00511 (LINC00511) on the human cancer progression and tumorigenesis. However, the role of LINC00511 in breast cancer tumourigenesis is still unknown. This research puts emphasis on the function of LINC00511 on the breast cancer tumourigenesis and stemness, and investigates the in-depth mechanism. METHODS: The lncRNA and RNA expression were measured using RT-PCR...
November 27, 2018: Journal of Experimental & Clinical Cancer Research: CR
Leiming Jiang, Xuexin Yu, Xueyan Ma, Haizhou Liu, Shunheng Zhou, Xu Zhou, Qianqian Meng, Lihong Wang, Wei Jiang
Previous studies have demonstrated that transcription factor-miRNA-gene feed-forward loops (FFLs) played important roles in tumorigenesis. However, the lncRNA-involved FFLs have not been explored very well. Understanding the characteristics of lncRNA-involved FFLs in breast cancer subtypes may be a key question with clinical implications. In this study, we firstly constructed an integrated background regulatory network. Then, based on mRNA, miRNA, and lncRNA differential expression, we identified 147, 140, 284, 1031 dysregulated FFLs for luminal A, luminal B, HER2+ and basal-like subtype of breast cancer, respectively...
November 16, 2018: Computational Biology and Chemistry
Alex J Gooding, Bing Zhang, Lalith Gunawardane, Abigail Beard, Saba Valadkhan, William P Schiemann
Disseminated breast cancer cells employ adaptive molecular responses following cytotoxic therapeutic insult which promotes their survival and subsequent outgrowth. Here we demonstrate that expression of the pro-metastatic lncRNA BORG (BMP/OP-Responsive Gene) is greatly induced within triple-negative breast cancer (TNBC) cells subjected to environmental and chemotherapeutic stresses commonly faced by TNBC cells throughout the metastatic cascade. This stress-mediated induction of BORG expression fosters the survival of TNBC cells and renders them resistant to the cytotoxic effects of doxorubicin both in vitro and in vivo...
November 22, 2018: Oncogene
Xu Bin, Yang Hongjian, Zhang Xiping, Chen Bo, Yang Shifeng, Tang Binbin
Some progresses have been made in research of long non-coding RNA (hereunder referred to as LncRNA) related to breast cancer. Lots of data about LncRNA transcription concerning breast cancer have been obtained from large-scale omics research (e.g. transcriptomes and chips). Some LncRNAs would become indices for detecting breast cancer and judging its development and prognosis. LncRNAs may affect genesis and development of breast cancer in multiple ways. Perhaps they could develop into potential targets for treating breast cancer if they are carcinogenic...
2018: Cancer Cell International
Huijuan Zeng, Jingjie Wang, Tao Chen, Kai Zhang, Jing Chen, Lulu Wang, Hanjun Li, Dilihumaer Tuluhong, Jieshou Li, Shaohua Wang
Several studies have demonstrated an important role for long non-coding RNA (lncRNA) in breast cancer progression. This study investigated the role of the lncRNA OIP5-AS1 in the progression of breast cancer. OIP5-AS1 was significantly upregulated in breast cancer tissues and breast cancer cell lines, and OIP5-AS1 downregulation inhibited the malignant behaviors of breast cancer in vitro and in vivo. For the depth exploration of mechanism of OIP5-AS1 in breast cancer, we found that miR-129-5p which was found had bind sites in the sequence of OIP5-AS1, expression in breast cancer tissues was negatively correlated with OIP5-AS1 and luciferase assays indicated that OIP5-AS1 acted as miR-129-5p sponge, resulting in upregulated expression of the SOX2 transcription factor...
November 15, 2018: Cancer Science
Xuguang Hu, Dan Ding, Jiayi Zhang, Jianguo Cui
Radiotherapy is a major therapeutic strategy for breast cancer, while cancer radioresistance remains an obstacle for the successful control of the tumor. Novel radiosensitizing targets are to be developed to overcome radioresistance. Recently, long non-coding RNAs (lncRNAs) were proved to play critical roles in cancer progression. Among all, lncRNA HOTAIR was found to participate in cancer metastasis and chemoresistance. In the present study, we aimed to investigate the radiosensitizing effects of targeting HOTAIR and the underlying mechanism...
November 14, 2018: Bioscience Reports
Yang Jiang, Lili Lin, Shen Zhong, Yangjun Cai, Fen Zhang, Xiaobo Wang, Rongrong Miao, Baodan Zhang, Shenmeng Gao, Xiaoqu Hu
Long noncoding RNAs (lncRNAs) are considered as regulators of gene expression in cancers. However, cancer profiling has little focused on noncoding genes. Here, we reported that RP11-115N4.1 (here renamed novel lncRNA inhibiting proliferation and metastasis [NLIPMT]) was downregulated in breast cancer tissues. Ectopic expression of NLIPMT inhibited mammary cell proliferation, motility in vitro. Moreover, lnc-NLIPMT reduced the growth of implanted MDA-MB-231 cells in vivo. Mechanistically, glycogen synthase kinase 3β (GSK3β) was identified as an effector protein regulated by lnc-NLIPMT...
November 11, 2018: Journal of Cellular Physiology
Zhihua Li, Liang Xu, Yong Liu, Shaokun Fu, Jianhong Tu, Yangyang Hu, Qiuyun Xiong
Postoperative fever is prevalent in many breast cancer patients. Some retrospective studies proposed that postoperative fever might also be considered as a rapid rough indicator for the poor prognosis of breast cancer patients. This study aims to explore the possible molecular mechanisms underlying the relapse of breast cancer patients with early postoperative fever. Our results indicated plasma levels of lncRNA MALAT1 were elevated in breast cancer patients with early postoperative fever and were associated with RFS...
2018: American Journal of Translational Research
Mingzhi Zhu, Xiaochun Wang, Yuanting Gu, Fang Wang, Lin Li, Xinguang Qiu
Increasing studies have highlighted the critical role of lncRNAs in cancer pathogenesis and development. LncRNA maternally expressed gene 3 (MEG3) was reported to function as a tumor suppressor in breast cancer. However, the detailed molecular mechanism of MEG3 involved in breast cancer progression remains far from being addressed. Our findings showed that MEG3 was downregulated and miR-21 was upregulated in breast cancer patient tissues and cells. MEG3 overexpression suppressed cell proliferation and glycolysis, and induced apoptosis in breast cancer cells...
October 31, 2018: Archives of Biochemistry and Biophysics
Leinan Yu, Qun Xu, Weixin Yu, Jianchun Duan, Guofang Dai
Emerging literature have illustrated the vital regulatory roles of long noncoding RNAs (lncRNAs) on the breast cancer tumorigenesis. Although series of researches have been proceeded on the pathogenesis, there are still much of unsolved mysteries worth investigating. This study uncovered that CASC15 expression level was aberrantly high-expressed in breast cancer tissue specimens and cells. Functionally, the loss-of-functional experiments showed that knockdown of CASC15 suppressed the malignant behaviors of breast cancer cells, such as proliferation, invasion and tumor growth in vitro and vivo...
October 30, 2018: Biochemical and Biophysical Research Communications
Xin-Xing Wang, Guang-Cheng Guo, Xue-Ke Qian, Dong-Wei Dou, Zhe Zhang, Xiao-Dong Xu, Xin Duan, Xin-Hong Pei
Background: Breast cancer has been the first death cause of cancer in women all over the world. Metastasis is believed to be the most important process for treating breast cancer. There is evidence that lncRNA MEG3 functions as a tumor suppressor in breast cancer metastasis. However, upstream regulation of MEG3 in breast cancer remain elusive. Therefore, it is critical to elucidate the underlying mechanism upstream MEG3 to regulate breast cancer metastasis. Methods: We employed RT-qPCR and Western blot to examine expression level of miR - 506 , DNMT1, SP1, SP3 and MEG3 ...
2018: Cancer Cell International
Farzaneh Raeisi, Mahdieh Abolfathi, Raheleh Ahmadi-Naji, Sara Iranparast, Esmat Noshadi, Arvand Akbari, Esmaeil Mahmoudi, Mansoor Khaledi, Asghar Arshi
Important regulatory roles of long non-coding RNAs (lncRNAs) have been recently found, and reported as useful biomarkers in cancer. To identify a potential expression of the new discovered lncRNA (ARA), during promotes cell proliferation, apoptosis inhibit, migration and cell cycle arrest, we firstly evaluate its expression in two cancer tissues (breast cancer and liver cancer) and then compared its variability expression in tumor versus non-tumor samples. Expression profile of ARA lncRNA was evaluated using qRT-PCR in paired tumor and marginal non-tumor samples collected from patients who had been referred to the Shiraz General...
October 26, 2018: Molecular Biology Reports
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