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https://www.readbyqxmd.com/read/30336535/multianalyte-determination-of-noacs-using-lc-ms-ms-and-comparison-with-functional-coagulation-assays
#1
Ludek Slavik, Jiri Lukes, David Friedecky, Monika Zhanelova, Marketa Nemcova, Jana Ulehlova, Jana Prochazkova, Antonin Hlusi, Miroslava Palova, Jan Vaclavik
BACKGROUND: Detection of new oral anticoagulant (NOAC) levels by screening, special and global tests, and liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) is important in clinical situations when the cause of bleeding needs to be determined. METHODS: We compared a routine coagulation test, special function test for NOACs, global coagulation test, and an LC-MS/MS method that enables simultaneous determination of apixaban, dabigatran and rivaroxaban in human plasma within one analysis to determine the optimal indication of the comparison methods, including their limitations and interferences...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30336534/the-link-between-selenium-oxidative-stress-and-pregnancy-induced-hypertensive-disorders
#2
REVIEW
Teofana O Bizerea, Stefana G Dezsi, Otilia Marginean, Ramona Stroescu, Alexandru Rogobete, Otilia Bizerea-Spiridon, Constantin Ilie
BACKGROUND: The first line of defence against oxidative stress (OS) are the endogenous antioxidants, such as the Se containing compounds. During pregnancy, OS is caused by the intense growth activity of the fetus; therefore, the placenta is a key place for the activity of many seleno-compounds such as glutathione-peroxidase and thioredoxinreductase. METHODS: This review aims to establish the link between the type of selenium compounds, their concentration, their metabolic pathways, and their role in both physiologic and pathologic processes during pregnancy...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30336509/-practical-evaluation-of-patients-with-syncopal-events
#3
Blanka Nemeth, Elisabeth Weber, Lars Christian Huber
Syncope is defined as a transient, self-limited loss of consciousness due to insufficient cerebral blood perfusion. In a clinical setting, syncopal events usually present a diagnostic dilemma due to its broad differential diagnosis ranging from banal to potentially harmful causes. In the absence of a working hypothesis, multiple tests are ordered that result in high costs but are of questionable diagnostic and therapeutic value. This article provides a practical overview and, based on international guidelines and selected studies, proposes a standardized approach to patients with syncope...
October 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/30336489/c-reactive-protein-and-platelet-lymphocyte-ratio-as-potential-tumor-markers-in-low-alpha-fetoprotein-hepatocellular-carcinoma
#4
Aslı Suner, Brian I Carr, Hikmet Akkiz, Gökhan Karakülah, Oguz Üsküdar, Kendal Yalçın, Sedef Kuran, Yaman Tokat, Sezai Yilmaz, Ayşegül Özakyol, Salih Tokmak, Tuğsan Ballı, Mehmet Yücesoy, Halil İbrahim Bahçeci, Abdulalh Ülkü, Tolga Akçam, Kamil Yalçın Polat, Nazım Ekinci, Halis Şimşek, Necati Örmeci, Abdulalh Sonsuz, Mehmet Demir, Murat Kılıç, Ahmet Uygun, Ali Demir, Anıl Delik, Burcu Arslan, Figen Doran, Engin Altıntaş, Tuncer Temel, Ahmet Bektaş
The hepatocellular carcinoma (HCC) tumor marker alpha-fetoprotein (AFP) is only elevated in about half of the HCC patients, limiting its usefulness in following the effects of therapy or screening. New markers are needed. It has been previously noted that the inflammation markers C-reactive protein (CRP) and platelet-lymphocyte ratio (PLR) are prognostically important and may reflect HCC aggressiveness. We therefore examined these 2 markers in a low-AFP HCC cohort and found that for HCCs > 2 cm, both markers significantly rise with an increasing maximum tumor diameter (MTD)...
October 18, 2018: Oncology
https://www.readbyqxmd.com/read/30336475/human-microglial-cells-undergo-proapoptotic-induction-and-inflammatory-activation-upon-in-vitro-exposure-to-a-naturally-occurring-level-of-aflatoxin-b1
#5
Jalil Mehrzad, Saman Hosseinkhani, Amir Mohammad Malvandi
OBJECTIVE: Knowledge regarding interactions of AFB1 with the human nervous system and how a naturally occurring level of AFB1 could potentially induce neuroimmune dysregulation is very limited. To assess the cellular effects of AFB1 on the human brain, we used the human microglia cell line CHME5 as a model to pinpoint its potential in vivo translation. METHODS: We used the CHME5 cell line culture system, multiplex qPCR, (chemi)bioluminescence, Luminex ELISA, and flow cytometry assays to evaluate the toxic effects of a naturally occurring level of AFB1 on human microglia...
October 18, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/30336474/c9orf72-repeat-expansion-frequency-among-patients-with-huntington-disease-genetic-testing
#6
Cristiane M Ida, Malinda L Butz, Patrick A Lundquist, D Brian Dawson
BACKGROUND: European studies identified the C9orf72 repeat expansion as the most frequent genetic alteration in patients with Huntington disease (HD)-like phenotypes but negative HD genetic testing. OBJECTIVE: To investigate C9orf72 repeat expansion frequency in individuals tested for HD in a North American tertiary referral laboratory. METHODS: Three hundred and seventy-three cases (115 positive and 258 negative for HD) were evaluated by genotyping PCR, with follow-up Southern blot and 5' repeat methylation status assessment by combined repeat-primed and methylation-specific PCR in a subset...
October 18, 2018: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/30336463/age-related-macular-degeneration-in-chronic-kidney-disease-a-meta-analysis-of-observational-studies
#7
Yi-Ju Chen, Ling Yeung, Chi-Chin Sun, Chien-Chieh Huang, Kuo-Su Chen, Yi-Hsuan Lu
BACKGROUND: Age-related macular degeneration (AMD) is an important cause of blindness in aged people. Chronic kidney disease (CKD) was reported to be associated with a higher risk of AMD. However, supporting evidence was inconsistent between studies. This work intends to examine whether a positive association exists between CKD and AMD by systematic review and meta-analysis. METHODS: A systematic search of electronic databases (Medline, PubMed, Cochrane and EMBASE) and reference lists on June 2017...
October 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/30336456/%C3%A3-douard-manet-s-tabes-dorsalis-from-painful-ataxia-to-phantom-limb
#8
Julien Bogousslavsky, Laurent Tatu
Édouard Manet (1832-1883) is considered the "father" of impressionism and even of twentieth century modern art. Manet's genius involved getting away from the classical narrative or historical topics and replacing them by the banality of daily life. Technically, he erased volumes into flat two-dimensional coloured planes, and distorted conventional perspective with often gross brushstrokes intentionally giving an "unfinished" aspect to the work. It is little known that Manet had a very painful second part of his life, due to excruciating limb and chest pains, which developed in parallel with proprioceptive ataxia and gait imbalance...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/30336435/elucidating-temporal-trends-in-trace-element-exposure-of-green-turtles-chelonia-mydas-using-the-toxicokinetic-differences-of-blood-and-scute-samples
#9
C A Villa, I Bell, C Madden Hof, C J Limpus, C Gaus
Blood is considered a suitable biomonitoring matrix for evaluating relatively recent exposure to environmental contaminants since abrupt changes in exposure regimes are rapidly reflected in blood. On the other hand, keratinized tissues, such as turtle scutes, are known to integrate trace element exposure over relatively long time periods. This study aimed to test the use of the differences in blood and scute to inform on the historical trace element exposure of green turtles. We propose a blood-scute kinetic model to predict how an increase in exposure would affect the concentrations in these two matrices over time...
October 9, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30336432/evaluation-of-the-estrogen-receptor-alpha-as-a-possible-target-of-bifenthrin-effects-in-the-estrogenic-and-dopaminergic-signaling-pathways-in-zebrafish-embryos
#10
Luísa Becker Bertotto, Subham Dasgupta, Sara Vliet, Stacia Dudley, Jay Gan, David C Volz, Daniel Schlenk
Bifenthrin (BF) is a pyrethroid insecticide widely used in urban and agricultural applications. Previous studies in embryos of zebrafish have shown that BF can affect estradiol biosynthesis and the dopaminergic system. To examine the role of the estrogen receptor (ER) in the endocrine effects of BF, embryos were exposed for 96 h to a mixture of 0.15 and 1.5 μg/L BF and an ER agonist (17α-ethynylestradiol - EE2) at 0.09 μg/L. Transcripts related to estrogenic (vitellogenin VTG) and dopaminergic (tyrosine hydroxylase (TH), dopamine receptor 1 (DR1), monoamine oxidase (MAO), and catechol-O-methyltransferase b (COMTb)) signaling pathways were investigated by qRT-PCR...
October 9, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30336412/phthalate-exposure-and-male-reproductive-outcomes-a-systematic-review-of-the-human-epidemiological-evidence
#11
REVIEW
Elizabeth G Radke, Joseph M Braun, John D Meeker, Glinda S Cooper
OBJECTIVE: We performed a systematic review of the epidemiology literature to identify the male reproductive effects associated with phthalate exposure. DATA SOURCES AND STUDY ELIGIBILITY CRITERIA: Six phthalates were included in the review: di(2-ethylhexyl) phthalate (DEHP), diisononyl phthalate (DINP), dibutyl phthalate (DBP), diisobutyl phthalate (DIBP), butyl benzyl phthalate (BBP), and diethyl phthalate (DEP). The initial literature search (of PubMed, Web of Science, and Toxline) included all studies of male reproductive effects in humans, and outcomes were selected for full systematic review based on data availability...
October 15, 2018: Environment International
https://www.readbyqxmd.com/read/30336403/radiological-assessment-of-congenital-talipes-equinovarus-clubfoot-is-it-worthwhile
#12
Surendra U Kamath, Jose Austine
The lack in consensus with regard to qualitative use of standard radiographs and their predictive value in evaluating congenital talipes equinovarus among infants continues to be apparent in clinical practice. Since standard radiographs continue to play a role in the assessment of clubfoot it is essential to ensure that the values measured are reliable and reproducible keeping in mind acceptable tolerances for clinical application. This study was undertaken to assess the inter-observer and the intra-observer reliability in estimation of talocalcaneal and talo-first metatarsal angles on standard radiographs done according to Simon's method...
June 8, 2018: Foot
https://www.readbyqxmd.com/read/30336402/endoscopic-resection-of-symptomatic-os-calcaneus-secundarius
#13
Tun Hing Lui
Os calcaneus secundarius is an accessory ossicle resulting from a secondary ossification center of the anterior facet of the calcaneus. It may cause chronic pain and limitation in inversion motion after inversion ankle sprain. Excision of the ossicle is indicated if the symptoms do not resolve with conservative treatment. A case of symptomatic os calcaneus secundarius, which was successfully resected endoscopically, is presented.
April 30, 2018: Foot
https://www.readbyqxmd.com/read/30336383/a-hybrid-camera-and-ultrasound-based-approach-for-needle-localization-and-tracking-using-a-3d-motorized-curvilinear-ultrasound-probe
#14
Mohammad I Daoud, Abdel-Latif Alshalalfah, Otmane Ait Mohamed, Rami Alazrai
Three-dimensional (3D) motorized curvilinear ultrasound probes provide an effective, low-cost tool to guide needle interventions, but localizing and tracking the needle in 3D ultrasound volumes is often challenging. In this study, a new method is introduced to localize and track the needle using 3D motorized curvilinear ultrasound probes. In particular, a low-cost camera mounted on the probe is employed to estimate the needle axis. The camera-estimated axis is used to identify a volume of interest (VOI) in the ultrasound volume that enables high needle visibility...
October 3, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/30336379/reliability-of-palatal-rugoscopy-for-sexual-dimorphism-in-forensic-dentistry-a-systematic-literature-review-and-meta-analysis
#15
REVIEW
Ramon Nazareno Menezes Andrade, Walbert de Andrade Vieira, Ítalo de Macedo Bernardino, Ademir Franco, Luiz Renato Paranhos
OBJECTIVE: This study aimed to assess the validity of palatal rugoscopy for sexual dimorphism in the casework routine of forensic dentistry. DESIGN: A systematic literature reviews was established following the Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) and Cochrane guidelines. Six electronic databases were searched as the primary source of information. "Grey literature" was included to avoid selection and publication bias...
October 11, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/30336365/plasmonics-yields-efficient-electron-transport-via-assembly-of-shell-insulated-au-nanoparticles
#16
Chuanping Li, David Cahen, Ping Wang, Haijuan Li, Jie Zhang, Yongdong Jin
Junctions built from metallic nanoparticles (NPs) can circumvent the diffraction limit and combine molecular/nanoelectronics with plasmonics. However, experimental advances in plasmon-assisted electron transport at the nanoscale have been limited. We construct junctions of a robust, molecule-free, suspended film, built solely from AuNPs, capped by SiO2 shells (Au@SiO2 ), which give insulating tunneling gaps up to 3.6 nm between the NPs. Current measured across monolayers of such AuNPs shows ultra-long-range, plasmon-enabled electron transport (P-transport), beyond the range of normal electron tunneling across insulators...
October 5, 2018: iScience
https://www.readbyqxmd.com/read/30336342/interplay-between-physical-cleaning-membrane-pore-size-and-fluid-rheology-during-the-evolution-of-fouling-in-membrane-bioreactors
#17
M C Martí-Calatayud, S Schneider, S Yüce, M Wessling
Fouling is one of the most pressing limitations during operation of membrane bioreactors, as it increases operating costs and is the cause of short membrane lifespans. Conducting effective physical cleanings is thus essential for keeping membrane operation above viable performance limits. The nature of organic foulants present in the sludge and the membrane properties are among the most influential factors determining fouling development and thus, efficiency of fouling mitigation approaches. The role of other factors like sludge viscosity on fouling is still unclear, given that contradictory effects have been reported in the literature...
October 10, 2018: Water Research
https://www.readbyqxmd.com/read/30336319/simple-synthesis-and-characterization-of-l-cystine-functionalized-%C3%AE-feooh-for-highly-efficient-hg-ii-removal-from-contamined-water-and-mining-waste
#18
Luiz F O Maia, Rodrigo C Hott, Patricia C C Ladeira, Bruno Lemos Batista, Thaina G Andrade, Mayra S Santos, Márcia C S Faria, Luiz C A Oliveira, Douglas S Monteiro, Márcio C Pereira, Jairo Lisboa Rodrigues
l-Cystine functionalized δ-FeOOH nanoparticles (Cys-δ-FeOOH) were prepared by a cheap and straightforward method for using as an adsorbent of Hg(II) in aqueous solution. X-ray diffraction (XRD), attenuated total reflectance infrared spectroscopy (ATR-IR), and Raman spectroscopy confirmed that Cys-δ-FeOOH was successfully synthesized. Cys-δ-FeOOH with 14 nm crystal size, 34 m2  g-1 surface area, and 9 nm pore size were produced. The functionalization of the δ-FeOOH surface with cysteine decreases the point of zero charge of the iron oxyhydroxide from 8...
October 13, 2018: Chemosphere
https://www.readbyqxmd.com/read/30336315/electrochemical-disinfection-using-a-modified-reticulated-vitreous-carbon-cathode-for-drinking-water-treatment
#19
Yanchao Jin, Yijun Shi, Riyao Chen, Xiao Chen, Xi Zheng, Yaoxing Liu
A reticulated vitreous carbon (RVC) cathode modified by anodic polarization in 20 wt% H2 SO4 solution was used for drinking water disinfection under a neutral low electrolyte concentration (0.25 g/L Na2 SO4 ) condition. The contribution of the modified RVC anode and the Ti/RuO2 cathode to disinfection was investigated. The influences of current, initial Escherichia coli load, temperature and water volume were studied. The results show that H2 O2 generation increased to approximately three times using the modification of the RVC...
October 11, 2018: Chemosphere
https://www.readbyqxmd.com/read/30336308/folate-and-vitamin-b12-levels-in-early-pregnancy-and-maternal-obesity
#20
Eimer G O'Malley, Ciara M E Reynolds, Shona Cawley, Jayne V Woodside, Anne M Molloy, Michael J Turner
OBJECTIVE: There is good evidence that periconceptual Folic Acid (FA) supplementation can prevent two thirds of Neural Tube Defects (NTDs). A two-fold increase in NTD rates have been associated with maternal obesity and, based on limited evidence, national guidelines have recommended prescribing high dose FA for women with a Body Mass Index (BMI) >29.9 kg/m2 . This observational study examined the relationship between maternal BMI and serum folate, red blood cell (RBC) folate and plasma vitamin B12 measurements in early pregnancy...
October 4, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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