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Marisha Sharma, Sunil K Gupta, Baisakhi Majumder, Vivek K Maurya, Farah Deeba, Afroz Alam, Vivek Pandey
Drought is a major concern for sustainable yield under changing environment. Soybean, an economically important oil and protein crop, is prone to drought resulting in yield instability. Salicylic acid (SA), a multifaceted growth hormone, modulates a series of parallel processes to confer drought tolerance thereby relieving yield limitations. The present study was performed in soybean plants treated with SA (0.5 mM) through seed pretreatment under drought regimes: severe stress (50% RWC) and moderate stress (75% RWC), and rehydration...
August 6, 2018: Plant Physiology and Biochemistry: PPB
Jinling Wang, Xiuju Sun
Kidney cancer is one of the deadly cancers and is the cause of significant number of deaths worldwide. The treatments used for the treatment of kidney cancer are limited and associated with number of side effects. Therefore, there is need for the development of new drug options or to identify novel therapeutic targets for the treatment of kidney cancer. In this study we investigated the potential of miR-375 as the therapeutic target for the treatment of Kidney cancer. The results revealed that miR-375 is significantly downregulated in the Kidney cancer cells...
August 2, 2018: Environmental Toxicology and Pharmacology
Lam Ngoc Trac, Stine Nørgaard Schmidt, Philipp Mayer
It is challenging to conduct aquatic tests with highly hydrophobic and volatile chemicals while avoiding substantial sorptive and evaporative losses. A simple and versatile headspace passive dosing (HS-PD) method was thus developed for such chemicals: The pure liquid test chemical was added to a glass insert, which was then placed with the open end in the headspace of a closed test system containing aqueous test medium. The test chemical served as the dominating partitioning donor for establishing and maintaining maximum exposure levels in the headspace and aqueous solution, without direct contact between the donor and the test medium...
July 25, 2018: Chemosphere
Viviana Maresca, Lina Fusaro, Sergio Sorbo, Antonietta Siciliano, Stefano Loppi, Luca Paoli, Fabrizio Monaci, Elham Asadi Karam, Marina Piscopo, Marco Guida, Emilia Galdiero, Marilena Insolvibile, Adriana Basile
This study evaluated the biological effects of highly polluted freshwater environment (Regi Lagni channels, S Italy) on the aquatic moss Leptodictyum riparium, exposed in bags at three sites representative of different environmental conditions and characterized by different heavy metal burdens. Bioaccumulation, ultrastructural alterations, Reactive Oxygen Species (ROS) production, antioxidant enzymes activity and DNA damage were assessed. To better evaluate the biological response of the moss species to heavy metals, the same biological parameters were assessed also in L...
August 8, 2018: Ecotoxicology and Environmental Safety
Laura Rodriguez-Lorenzo, Sarah D Rafiee, Corine Reis, Ana Milosevic, Thomas L Moore, Sandor Balog, Barbara Rothen-Rutishauser, Curzio Ruegg, Alke Petri-Fink
The lack of understanding of fundamental nano-bio interactions, and difficulties in designing particles stable in complex biological environments are major limitations to their translation into biomedical clinical applications. Here we present a multi-parametric approach to fully characterize targeted nanoparticles, and emphasizes the significant effect that each detail in the synthetic process can have on downstream in vitro results. Through an iterative process, particles were designed, synthesized and tested for physico-chemical and bio-interactive properties which allowed the optimization of nanoparticle functionality...
July 31, 2018: Colloids and Surfaces. B, Biointerfaces
Liyun Yin, Bijuan Chen, Bin Xia, Xiaotao Shi, Keming Qu
Uptake and toxicity of microplastics on marine organisms have been reported elsewhere. However, there is limited knowledge regarding the ecological effects of microplastics on marine organisms. In this study, we investigated the effects of polystyrene microplastics (1 × 106 microspheres per L) on the behavior, energy reserve and nutritional composition of juvenile jacopever (Sebastes schlegelii). Compared to the controls, fish treated by microplastics showed lower sensitivity toward the added food in the tank, and increased foraging time, indicating that microplastics significantly weakened feeding activity of the fish...
August 3, 2018: Journal of Hazardous Materials
Radhouene Doggui, Rahma Mahjoub, Wassef Lotfi Aissa, Imen Tounsi, Zeineb Allagui, Zmorda Cherif, Sihem Haj Sassi, Sinda Ennigrou, Dhiaeddine Edriss, Jalila El Ati, Amina Bibi
Free thyroxine (FT4) quantification is continuing to be a concern. The purpose of the following study was to evaluate the analytical performance of Tosoh AIA900 based on a one-step technique and its comparison to Access 2 (two-step technique) over different clinical contexts (euthyroid, thyroid disorders, uncontrolled diabetes, renal failure and pregnancy). The protocol established by the French society of Clinical Biology was used to evaluate: imprecision, limit of detection, trueness, linearity, interferences and method comparisons...
July 26, 2018: Journal of Pharmaceutical and Biomedical Analysis
Nira Liberman, Reuven Dar
BACKGROUND AND OBJECTIVES: In recent years we have proposed and investigated the Seeking Proxies for Internal States (SPIS) model of obsessive-compulsive disorder (OCD), which postulates that deficient access to internal states is a key feature of the disorder. According to this model, rules and rituals that often characterize people with OCD can be understood as proxies for deficiently accessible internal states. Here we compliment this earlier experimental work by examining whether reliance on proxies for internal states in everyday life is associated with OCD...
August 4, 2018: Journal of Behavior Therapy and Experimental Psychiatry
Sherwin Ting, Alan Lam, Gerine Tong, Allen Chen, Heming Wei, JianJun Wu, Yue Ning Lam, Shaul Reuveny, Steve Oh
Human pluripotent stem cells (hPSCs) can be a renewable source for generating cardiomyocyte (CM) for treating myocardial infraction. In our previous publication, we described an integrated microcarrier-based wave reactor process for the expansion and differentiation of hPSCs to CMs on a rocker based platform. However, this platform is limited in terms of linear scalability and CMs purity. The present study describes ways to overcome these limitations by the use of a stirred scalable platform and incorporation of an additional lactate based purification step which increases CM purity...
August 1, 2018: Stem Cell Research
Leonardo Iaccarino, Arianna Sala, Silvia Paola Caminiti, Roberto Santangelo, Sandro Iannaccone, Giuseppe Magnani, Daniela Perani
Visual hallucinations (VH) are a core clinical feature of dementia with Lewy bodies (DLB), but their specific neural substrate remains elusive. We used 18 F-FDG-PET to study the neural dysfunctional signature of VH in a group of 38 DLB patients (mean age±SD 72.9 ± 7.5) with available anamnestic records, cognitive and neurological examination and NeuroPsychiatric Inventory assessing VH. We tested the voxel-wise correlation between 18 F-FDG-PET hypometabolism and VH NPI scores at the whole-group level, then adopting inter-regional correlation analysis to explore the resting-state networks (RSNs) metabolic connectivity in DLB patients with and without visual hallucinations, as compared to N = 38 age-matched healthy controls (HCs) (mean age±SD 71...
July 4, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Kelly S Mix, David Z Hambrick, V Rani Satyam, Alexander P Burgoyne, Susan C Levine
Multiple frameworks for categorizing spatial abilities exist but it has been difficult to verify them using exploratory factor analysis. The present study tested one of these frameworks-a 2 × 2 classification scheme that crossed the dimensions of static/dynamic and intrinsic/extrinsic (Uttal et al., 2013)-using confirmatory factor analysis with data on spatial performance from kindergarten (N = 251), third grade (N = 246) and sixth grade students (N = 241). For kindergarten and third grade students, four models were tested at each grade level: A 1-factor model, two 2-factor models (one static vs...
August 8, 2018: Cognition
Jing Zhao, Lili Yang, Yuhao Dai, Yingying Tang, Xiuqing Gong, Dongshu Du, Ya Cao
Protein kinases play a critical role in regulation of intracellular signal transduction, whose aberrant expression is closely associated with various dangerous human diseases. In this paper, we propose a feasible electrochemical assay of intracellular kinase by incorporating peptide nanoprobe-assisted signal labeling and signal amplification. Protein kinase A (PKA)-specific peptide P1 is self-assembled on the surface of a gold electrode, serine of which could be phosphorylated with catalysis of PKA in the presence of adenosine-5'-triphosphate (ATP)...
July 31, 2018: Biosensors & Bioelectronics
Bekir Çakıroğlu, Mahmut Özacar
In this study, a photoelectrochemical (PEC) biosensor was constructed by depositing supercapacitor carbon nanotubes (CNT) and Co3 O4 onto the anatase TiO2 coated ITO electrodes. Herein, supercapacitor Co3 O4 was employed as a semiconductor with a band gap of ~2.07 eV, and the supercapacitor behavior of the PEC system was improved by introducing CNT into the electrode material. Furthermore, a self-empowering glucose biosensor operating at 0 V was constructed for the first time. Also, upon the formation of p-n junction, Co3 O4 was rendered electron accepting material, unlike its usual use in photocatalytic systems...
July 27, 2018: Biosensors & Bioelectronics
Catherine McClure, Maureen Cunningham, Sheana Bull, Stephen Berman, Mandy A Allison
In this narrative review, we will present a brief overview of known disparities in children's language development based on socioeconomic status (SES) and efforts in the primary care setting to promote children's language development. Next, we will define mobile-health (m-health) and review the limited, published literature regarding the effectiveness of m-health interventions in promoting children's health, in general, and language development, in particular. Finally, we will discuss the potential role of smart phone applications to increase parental behaviors that promote their children's language development as well as challenges that should be addressed as the field of m-health continues to grow...
August 8, 2018: Academic Pediatrics
Sofiene Bouali, Imed Ben Said, Alia Zehani, Cyrine Drissi, Asma Bouhoula, Jalel Kallel, Hafedh Jeme
OBJECTIVE: The purpose of this study is to present an illustrative case of pediatric intracranial anaplastic gangliogliomas and to systematically review the current published literature in the pediatric population. METHODS: A comprehensive literature search for this review was conducted on the Pubmed, Scopus, Web of Science, PsycINFO, Cochrane, and Embase databases. Search term combinations included "ganglioglioma" "anaplastic" "pediatrics", "children" and "intracranial"...
August 8, 2018: World Neurosurgery
Marcelo Magaldi Oliveira, Leonardo Welhinger, Jose Augusto Malheiros, Arthur Nicolato, Andre Prosdocimi, Luiza Guerra, Pollyana Hv Costa, Carlos Eduardo Ferrarez, Mauro Tostes Ferreira, Eric Sauvageau, Ricardo Hanel
BACKGROUND: Intracranial-intracranial (IC) bypass surgery involves the use of significant technical bimanual skills. Indications for this procedure are limited, so training in a simulator with brain vessels similarity could maintain micro-surgical dexterity. Our goal is to describe the human placenta vascular anatomy to guide IC-IC bypasses apprenticeship. METHODS: Human placenta vascular anatomy was reported and validated with comparison to brain main vessels after studying the vascular tree of 100 placentas...
August 8, 2018: World Neurosurgery
Zheng Cui, Jie Liao, Naeun Cheong, Christopher Longoria, Gaoyuan Cao, Horace M DeLisser, Rashmin C Savani
Acute lung injury results in early inflammation and respiratory distress, and later fibrosis. The glycosaminoglycan hyaluronan (HA) and the Receptor for Hyaluronan-Mediated Motility (RHAMM, CD168) have been implicated in the response to acute lung injury. We hypothesized that, compared to wild type (WT) mice, RHAMM knockout (KO) mice would be protected from, whereas mice with macrophage-specific transgenic overexpression of RHAMM (TG) would have worse inflammation, respiratory distress and fibrosis after intratracheal (IT) bleomycin...
August 8, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
Ricardo Madrigal-Burgaleta, Lorena Bernal-Rubio, Maria Pilar Berges-Gimeno, Laura Victoria Carpio-Escalona, Patricia Gehlhaar, Emilio Alvarez-Cuesta
BACKGROUND: Large-scale studies of Drug Provocation Testing (DPT) or Rapid Drug Desensitization (RDD) for hypersensitivity to antineoplastics and biologicals are scarce and limited to a few institutions OBJECTIVE: Our aim was to review our experience with DPT and RDD in a large number of patients with a history of hypersensitivity to antineoplastics and biologicals and summarize the practical implications of that experience. METHODS: 7-year prospective, observational, longitudinal study with reactive patients referred to the Desensitization Program at Ramon y Cajal University Hospital (RCUH)...
August 8, 2018: Journal of Allergy and Clinical Immunology in Practice
Tobias Maetzig, Michael Morgan, Axel Schambach
Hematopoiesis depends on the controlled differentiation of hematopoietic stem cells to mature cells with defined functions. Although each cell population within the hematopoietic hierarchy can be described by phenotypic markers, isolation of marker pure populations does not necessarily result in cells with homogeneous functionality. However, techniques that enable the efficient characterization of cell behavior with high resolution are limited. While single cell transplantation assays demand high mouse numbers and workload, sequencing-based fate tracking techniques require the destruction of the host cell, substantial financial resources, bioinformatics expertise, and suffer from a delay between sample acquisition and data interpretation...
August 8, 2018: Experimental Hematology
Birendra Chaurasiya, Muye Zhou, Jiasheng Tu, Chunmeng Sun
Delivery of inhalational dry powders (DPs) to the lung of mice is pivotal for pre-clinical pharmacokinetic and pharmacodynamic investigations. Although several devices have been reported, their application is always limited by many factors, including complicated design, high price, commercially discontinued status, as well as requirement of special skills. Here, we have introduced a simple device for non-invasive and precise delivery of DPs in mice. We set up the self-made device using a 20 G cannula tube and a 1 mL syringe...
August 9, 2018: European Journal of Pharmaceutical Sciences
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