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Oct 4

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https://www.readbyqxmd.com/read/28090810/enamel-remineralization-effect-of-a-dentifrice-containing-calcium-sodium-phosphosilicate-an-optical-coherence-tomography-observation
#1
Saki Matsuyoshi, Ryosuke Murayama, Shunsuke Akiba, Chiaki Yabuki, Toshiki Takamizawa, Hiroyasu Kurokawa, Masashi Miyazaki
OBJECTIVE: The purpose of this study was to examine the effects of a dentifrice containing 5% calcium sodium phosphosilicate (CSP) on the remineralization of the enamel using optical coherence tomography (OCT). MATERIALS AND METHODS: Bovine incisors were sliced and shaped in a rectangular form. One group of five specimens was treated with undersaturated 0.1 M lactic acid buffer solution (pH 4.75) for 10 min and then placed in artificial saliva (pH 7.0) (De group)...
January 16, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28089219/prognostic-factors-of-epiretinal-membranes-a-systematic-review
#2
REVIEW
A I M Miguel, A Legris
INTRODUCTION: Epiretinal membranes (ERM) have been increasingly characterized with the advent of new optical coherence tomographies (OCTs). We intended to perform a systematic review regarding prognostic factors (PF) of ERM after surgery. MATERIALS AND METHODS: Systematic review of electronic databases was performed (last date of search was 10 August 2015): Medline, Scopus, Google Scholar, clinicaltrials.gov and current controlled trials. Search queries included: "membrane", "pucker", "prognosis", "prognostic", "epiretinal", "épirétinienne"...
January 11, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28087069/safety-tolerability-and-antiviral-effect-of-rg-101-in-patients-with-chronic-hepatitis-c-a-phase-1b-double-blind-randomised-controlled-trial
#3
Meike H van der Ree, J Marleen de Vree, Femke Stelma, Sophie Willemse, Marc van der Valk, Svend Rietdijk, Richard Molenkamp, Janke Schinkel, Ad C van Nuenen, Ulrich Beuers, Salah Hadi, Marten Harbers, Eva van der Veer, Kai Liu, John Grundy, Amy K Patick, Adam Pavlicek, Jacqueline Blem, Michael Huang, Paul Grint, Steven Neben, Neil W Gibson, Neeltje A Kootstra, Hendrik W Reesink
BACKGROUND: miR-122 is an important host factor for hepatitis C virus (HCV) replication. The aim of this study was to assess the safety and tolerability, pharmacokinetics, and antiviral effect of a single dose of RG-101, a hepatocyte targeted N-acetylgalactosamine conjugated oligonucleotide that antagonises miR-122, in patients with chronic HCV infection with various genotypes. METHODS: In this randomised, double-blind, placebo-controlled, multicentre, phase 1B study, patients were randomly assigned to RG-101 or placebo (7:1)...
January 10, 2017: Lancet
https://www.readbyqxmd.com/read/28079690/noncontact-evaluation-of-corneal-grafts-swept-source-fourier-domain-oct-versus-high-resolution-scheimpflug-imaging
#4
Eszter Szalai, Gábor Németh, Ziad Hassan, László Módis
PURPOSE: To study the reliability and repeatability of anterior segment measurements in patients who underwent penetrating keratoplasty with swept light source Fourier domain anterior segment optical coherence tomography (SS-OCT) in comparison with a high-resolution Scheimpflug camera. METHODS: Keratometry (K) and elevation data of the anterior and posterior corneal surfaces, central corneal thickness, and anterior chamber depth were determined in 56 postkeratoplasty eyes (mean age: 59...
January 11, 2017: Cornea
https://www.readbyqxmd.com/read/28077369/the-relationship-between-central-visual-field-sensitivity-and-macular-ganglion-cell-inner-plexiform-layer-thickness-in-glaucoma
#5
Ji-Woong Lee, Esteban Morales, Farideh Sharifipour, Navid Amini, Fei Yu, Abdelmonem A Afifi, Anne L Coleman, Joseph Caprioli, Kouros Nouri-Mahdavi
AIMS: To explore the correlation of local macular ganglion cell/inner plexiform layer (GC/IPL) thickness measurements with sensitivity at individual test locations on the central 10-2 visual fields (VFs) in patients with glaucoma. METHODS: One hundred thirty-seven eyes of 125 patients with spectral domain optical coherence tomography (OCT) and 10-2 VFs were included. The exported thickness matrices (200×200) of GC/IPL measurements were centred on the fovea. Total deviation values at each test location were correlated with the 20 000 GC/IPL thickness measurements in the corresponding inferior or superior hemiretina, and areas of highest correlation were plotted...
January 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28070820/development-of-a-new-catheter-prototype-for-laser-thrombolysis-under-guidance-of-optical-coherence-tomography-oct-validation-of-feasibility-and-efficacy-in-a-preclinical-model
#6
Rouven Berndt, Rene Rusch, Lars Hummitzsch, Matthias Lutz, Katharina Heß, Katharina Huenges, Bernd Panholzer, Christoph Otte, Assad Haneya, Georg Lutter, Alexander Schlaefer, Jochen Cremer, Justus Groß
In this feasibility study, a novel catheter prototype for laser thrombolysis under the guidance of optical coherence tomography (OCT) was designed and evaluated in a preclinical model. Human arteries and veins were integrated into a physiological flow model and occluded with thrombi made from the Chandler Loop. There were four experimental groups: placebo, 20 mg alteplase, laser, 20 mg alteplase + laser. The extent of thrombolysis was analyzed by weighing, OCT imaging and relative thrombus size. In the alteplase group, thrombus size decreased to 0...
January 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28068388/the-association-between-foveal-morphology-and-macular-pigment-spatial-distribution-an-ethnicity-study
#7
Irene Ctori, Byki Huntjens
PURPOSE: Macular pigment (MP) spatial distribution varies considerably among individuals. We investigated ethnic variations in MP spatial distribution in relation to foveal architecture. METHODS: We measured MP optical density (MPOD) using heterochromatic flicker photometry (MAP test, City, University of London) in 76 white, 80 South Asian and 70 black volunteers (18 to 39 years). MPOD spatial profiles were classified objectively as exponential, ring-like or central dip, based on deviations away from an exponential fit...
2017: PloS One
https://www.readbyqxmd.com/read/28067724/acute-central-serous-chorioretinopathy-factors-influencing-episode-duration
#8
Alejandra Daruich, Alexandre Matet, Laetitia Marchionno, Jean-Dominique De Azevedo, Aude Ambresin, Irmela Mantel, Francine Behar-Cohen
PURPOSE: To evaluate the influence of clinical and multimodal imaging parameters on the duration of acute central serous chorioretinopathy (CSCR) episodes. METHODS: Consecutive patients with first, treatment-naïve central serous chorioretinopathy episodes presenting within 20 days of symptoms onset were prospectively included. They were reevaluated 15 days to 20 days later, followed by monthly evaluation for 6 months. Subfoveal choroidal thickness (SFCT), fluorescein leakage intensity on fluorescein angiography, elevation of retinal pigment epithelium (RPE) lesions at leakage sites, focal/multifocal pattern of indocyanine green angiography (ICGA) at baseline, time-dependent pattern of subretinal fluid (SRF) resorption on OCT using volume segmentation, history of corticosteroid intake and mean blood pressure were evaluated using univariate (Log rank test) and multivariate (Cox proportional hazard regression) survival analysis...
January 6, 2017: Retina
https://www.readbyqxmd.com/read/28063879/the-effect-of-vishram-a-grass-roots-community-based-mental-health-programme-on-the-treatment-gap-for-depression-in-rural-communities-in-india-a-population-based-study
#9
Rahul Shidhaye, Vaibhav Murhar, Siddharth Gangale, Luke Aldridge, Rahul Shastri, Rachana Parikh, Ritu Shrivastava, Suvarna Damle, Tasneem Raja, Abhijit Nadkarni, Vikram Patel
BACKGROUND: VISHRAM was a community-based mental health programme with the goal of addressing the mental health risk factors for suicide in people from 30 villages in the Amravati district in Vidarbha, central India. We aimed to assess whether implementation of VISHRAM was associated with an increase in the proportion of people with depression who sought treatment (contact coverage). METHODS: A core strategy of VISHRAM was to increase the demand for care by enhancing mental health literacy and to improve the supply of evidence-based interventions for depression and alcohol-use disorders...
January 4, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28060389/choroidal-thickness-in-childhood-obesity
#10
Ayse Derya Bulus, Mehmet Erol Can, Ata Baytaroglu, Gamze Dereli Can, Hasan Basri Cakmak, Nesibe Andiran
BACKGROUND AND OBJECTIVE: To evaluate the effects of obesity on choroidal thickness (CT) in childhood. PATIENTS AND METHODS: Forty-four patients with obesity (study group) and 42 healthy children (control group) were enrolled in the study. Subjects underwent a complete ocular examination. The mean CT was measured by enhanced depth imaging optical coherence tomography (EDI-OCT). Body mass index (BMI) was calculated. RESULTS: Mean BMI value was 31...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28059563/resolution-characteristics-of-optical-coherence-tomography-for-dental-use
#11
Hiroshi Watanabe, Ami Kuribayashi, Yasunori Sumi, Tohru Kurabayashi
OBJECTIVES: The purpose of this study was to clarify resolution characteristics of optical coherence tomography (OCT) for dental use. METHODS: Two types of swept-source OCT machines (SS-OCTs) were employed in this study. To clarify their resolution characteristics, we newly developed a glass chart device with a ladder pattern of wavelengths, which ranged from (4 x 2) µm to (1024 x 2) µm, as well as a star-target pattern, a grid pattern, and a spatial frequency response pattern...
January 6, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28057647/characterisation-of-choroidal-morphological-and-vascular-features-in-diabetes-and-diabetic-retinopathy
#12
Preeti Gupta, Sri Gowtham Thakku, Charumathi Sabanayagam, Gavin Tan, Chui Ming Gemmy Cheung, Ecosse L Lamoureux, Tien-Yin Wong, Ching-Yu Cheng
AIM: We aimed to characterise specific morphological and vascular features of the choroid in Indian adults with diabetes and diabetic retinopathy (DR). METHODS: Consecutive participants from the Singapore Indian Eye Study's 6-year follow-up examination underwent choroidal imaging using spectral domain optical coherence tomography (OCT) with enhanced depth imaging. Raw OCT images were loaded on a custom-written application on MATLAB that enabled delineation for detailed morphological and vascular analyses...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057645/optical-coherence-tomography-angiography-in-acute-non-arteritic-anterior-ischaemic-optic-neuropathy
#13
Sourabh Sharma, Marcus Ang, Raymond P Najjar, Chelvin Sng, Carol Y Cheung, Annadata V Rukmini, Leopold Schmetterer, Dan Milea
PURPOSE: To characterise vascular changes in eyes with acute non-arteritic anterior ischaemic optic neuropathy (NAION), using optical coherence tomography angiography (OCT-A) imaging. METHODS: This hospital-based observational case-control study included included five patients with acute NAION (6 eyes), within 7 days after onset of symptoms and 19 age-matched healthy controls (19 eyes). OCT-A (RTVue XR 100; Optovue, Fremont, California, USA), covering a 4.5×4...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057643/retinal-segmented-layers-with-strong-aquaporin-4-expression-suffered-more-injuries-in-neuromyelitis-optica-spectrum-disorders-compared-with-optic-neuritis-with-aquaporin-4-antibody-seronegativity-detected-by-optical-coherence-tomography
#14
Chun Xia Peng, Hong Yang Li, Wei Wang, Jun Qing Wang, Lei Wang, Quan Gang Xu, Shan Shan Cao, Huan Fen Zhou, Shuo Zhao, Shi Hui Wei
PURPOSE: To evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO) with ON eyes (NMO-ON) compared with an AQP4-Ab seronegative ON (AQP4-Ab-/ON) cohort using optical coherence tomography (OCT). METHODS: We recruited 109 patients with ON (161 eyes) and 47 healthy controls. All patients with ON were subdivided into three subcohorts: 37 patients (54 eyes) with AQP4-Ab+/ON, 45 patients (65 eyes) with AQP4-Ab-/ON and 27 patients (42 eyes) with NMO-ON...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057069/choroidal-thickness-findings-in-two-siblings-with-nanophthalmos-by-swept-source-oct-a-case-report
#15
Hiroyuki Kaneko, Ari Shinojima, Mori Ryusaburo, Akiyuki Kawamura, Mitsuko Yuzawa
BACKGROUND: We investigated choroidal thicknesses at five sites in two siblings (four eyes) with nanophthalmos using swept-source optical coherence tomography. CASE PRESENTATION: Case 1, a 51-year-old Japanese female with high hyperopia (Right: +20.5 Dioptors, Left: +19.5 Dioptors), had axial lengths of 15.6 mm in both eyes. Case 2, a 55-year-old Japanese male with high hyperopia (Right: +22.5 Dioptors, Left: +22.8 Dioptors), had axial lengths of 14.8 and 14.7 mm in the right and left eyes, respectively...
January 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28056057/flat-anterior-chamber-after-trabeculectomy-in-secondary-angle-closure-glaucoma-with-best1-gene-mutation-case-series
#16
Yimin Zhong, Xinxing Guo, Hui Xiao, Jingyi Luo, Chengguo Zuo, Xiaobo Huang, Jingjing Huang, Lan Mi, Qingjiong Zhang, Xing Liu
PURPOSE: Trabeculectomy has been regarded as a mainstay of initial treatment in eyes of angle closure glaucoma (ACG) with peripheral anterior synechia > 180° in the Chinese population while its efficacy in secondary ACG with BEST1 gene mutation remains unclear. We set out to investigate the treatment outcome of trabeculectomy for secondary ACG in a group of patients with autosomal recessive bestrophinopathy (ARB). METHODS: In this retrospective case series study, 8 secondary ACG patients with ARB and their 4 recruited family members underwent a thorough ophthalmic examination including best-corrected visual acuity, Goldmann applanation tonometry, gonioscopy, and fundus examinations...
2017: PloS One
https://www.readbyqxmd.com/read/28052658/laminin-modulates-the-stem-cell-population-in-lm05-e-murine-breast-cancer-cells-through-the-activation-of-the-mapk-erk-pathway
#17
Damián E Berardi, Diego Raffo, Laura B Todaro, Marina Simian
Purpose: We investigated the effects of laminin on the fraction of cells with self-renewing capacity in the estrogen-dependent, tamoxifen-sensitive LM05-E breast cancer cell line. We also determined whether laminin affected the response to tamoxifen. Materials and Methods: The LM05-E breast cancer cell line was used as a model for all experiments. Aldehyde dehydrogenase (ALDH) activity, clonogenic and mammosphere assays were performed to measure the effects of laminin on modulation of the stem cell subpopulation...
December 6, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28050323/intravitreal-bevacizumab-treatment-in-type-2-idiopathic-macular-telangiectasia
#18
Tuğba Aydoğan, Gürkan Erdoğan, Cihan Ünlü, Ahmet Ergin
OBJECTIVES: To evaluate the efficacy of intravitreal bevacizumab treatment in type 2 idiopathic macular telangiectasia (IMT). MATERIALS AND METHODS: Six eyes of 5 patients with type 2 IMT who received intravitreal bevacizumab between 2009 and 2014 were included in this study. All the patients had an ophthalmological examination including best corrected visual acuity (BCVA), dilated fundus examination, spectral domain optical coherence tomography (OCT) and fluorescein angiography...
December 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28042632/macular-thickness-in-healthy-saudi-adults-a-spectral-domain-optical-coherence-tomography-study
#19
Waseem M Al-Zamil, Fahad M Al-Zwaidi, Sanaa A Yassin
To determine the macular thickness in the eyes of healthy Saudi adults using spectral-domain optical coherence tomography (SD-OCT). Methods: This is a prospective, cross-sectional study, including 158 healthy participants between August and December 2015. Mean subject age was 29.9 ± 7.85 years old. All participants underwent full ophthalmic evaluation, including SD-OCT imaging, and axial length measurement. Data from the right eye were included. Mean retinal thickness was determined. Correlations between retinal thickness and gender, age, axial length, and spherical equivalence were analyzed...
January 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28040524/corneal-higher-order-aberrations-in-infectious-keratitis
#20
Eisuke Shimizu, Takefumi Yamaguchi, Yukari Yaguchi, Murat Dogru, Yoshiyuki Satake, Kazuo Tsubota, Jun Shimazaki
PURPOSE: To characterize the corneal higher-order aberrations (HOAs) in eyes with acanthoamoeba keratitis (AK), bacterial keratitis (BK), and fungal keratitis (FK). DESIGN: Retrospective consecutive case series. METHODS: This retrospective study includes 18 normal subjects and 63 eyes of 62 consecutive patients with corneal scarring due to AK (20 eyes), BK (35 eyes) and FK (8 eyes) from 2010 to 2016. HOAs of the anterior and posterior surfaces and the total cornea were analyzed by anterior segment optical coherence tomography (AS-OCT)...
December 28, 2016: American Journal of Ophthalmology
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