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Oct 4

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https://www.readbyqxmd.com/read/29783074/fsh-receptor-binding-inhibitor-restrains-follicular-development-and-possibly-attenuates-carcinogenesis-of-ovarian-cancer-through-down-regulating-expression-levels-of-fshr-and-er%C3%AE-in-normal-ovarian-tissues
#1
Gong Zhuandi, Che Tuanjie, Lai Luju, Ayimuguli Abdiryim, Deng Yingying, Liang Haoqin, Wei Suocheng, Ding Li
OBJECTIVES: The current study aimed to investigate FSH receptor binding inhibitor (FRBI) effects in the expressions of FSH receptor (FSHR) and estrogen receptor-beta (ERβ) in the mice ovaries at the gene and protein levels, also to find the potential efficacy of FRBI on suppressing ovarian cancer through down-regulating over-expression of FSHR and ERβ in the normal ovarian tissues. METHODS: 180 female mice were randomized into six groups (n = 30). Mice of FRBI-1, FRBI-2 and FRBI-3, FRBI-4 were intramuscularly injected with FRBI of 10, 20, 30 and 40 mg/kg, respectively, for five consecutive days...
May 18, 2018: Gene
https://www.readbyqxmd.com/read/29781332/a-novel-phenolic-propanediamine-moiety-based-lung-targeting-therapy-for-asthma
#2
Jianbo Li, Yang Yang, Didi Wan, Youmei Peng, Jinjie Zhang
Asthma is one of the most prevalent chronic inflammatory diseases of lung. Current asthma therapy using inhaled corticosteroid often results in undesired treatment outcome due to poor compliance and drugs' lack of tissue specificity. N,N,N'-trimethyl-N'-(2-hydroxyl-3-methyl-5-123 Iiodobenzyl)-1,3-propanediamine (HIPD), a phenolic propanediamine derivative, has been used as an imaging agent for localized pulmonary diseases. Inspired by this, N,N,N'-trimethyl-N'-(4-hydroxyl-benzyl)-1,3-propanediamine (TPD), a new HIPD analog, was proposed as a lung-targeting ligand and covalently conjugated to an anti-inflammatory compound Rhein for asthma therapy...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29780933/adjustments-of-haptics-length-for-tilted-intraocular-lens-after-intrascleral-fixation
#3
Helena Yuri Kurimori, Makoto Inoue, Akito Hirakata
Purpose: To report the findings and surgical techniques on two cases of severe tilting of an intraocular lens (IOL) that had been implanted with intrascleral fixation and the tilting was detected by anterior segment optical coherence tomography (AS-OCT). Observations: Two patients underwent flanged intrascleral fixation of an IOL with the double needle technique. AS-OCT showed that the tilt of IOL was 25.3° in Case 1 and was 38.1° in Case 2, and a second surgery was planned to reduce the IOL tilt...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29779260/fifteen-years-of-pmtct-hiv-and-syphilis-outcomes-in-haiti-from-monotherapy-to-option-b
#4
Marie Marcelle Deschamps, Deanna Jannat-Khah, Vanessa Rouzier, Jerry Bonhomme, Julma Pierrot, Myung Hee Lee, Elaine Abrams, Jean Pape, Margaret L McNairy
OBJECTIVE: To evaluate mother and infant outcomes in the largest prevention of mother-to-child-transmission (PMTCT) program in Haiti in order to identify gaps towards elimination of HIV and syphilis. METHODS: Based on retrospective data from HIV+ pregnant women and their infants enrolled in PMTCT care from 1999-2014, we assessed maternal enrolment in PMTCT, receipt of antiretrovirals before delivery, maternal retention through delivery, as well as infant enrolment in PMTCT, HIV testing, and HIV infection...
May 19, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29778081/molecular-aspect-of-silver-nanoparticles-regulated-embryonic-development-in-zebrafish-danio-rerio-by-oct-4-expression
#5
Biplab Sarkar, Suresh K Verma, Javed Akhtar, Surya Prakash Netam, Sanjay Kr Gupta, Pritam Kumar Panda, Koel Mukherjee
With the enhancement of commercial manifestation of silver nanoparticles, concerned has risen on their accumulation in aquatic system and consequent effects on fish development and metabolism. In this study, experiments were conducted to assess the impacts of silver nanoparticles on early life cycles of fish considering Zebrafish (Danio rerio) as experimental model. Silver nanoparticles were synthesized through chemical reduction method and characterized through UV-visible spectroscopy, dynamic light scattering (DLS), and HR-TEM...
May 4, 2018: Chemosphere
https://www.readbyqxmd.com/read/29776765/effects-of-artificial-tear-treatment-on-corneal-epithelial-thickness-and-corneal-topography-findings-in-dry-eye-patients
#6
B Çakır, E Doğan, E Çelik, T Babashli, T Uçak, G Alagöz
PURPOSE: To investigate the effects of artificial tear treatment on central corneal epithelial thickness, and central, mid-peripheral and peripheral corneal thicknesses in patients with dry eye disease (DED). MATERIAL-METHODS: Patients with DED underwent ocular examinations, including Schirmer-2 test, slit lamp examination for tear break-up time (BUT), corneal topography (CT) for measuring mean central, mid-peripheral and peripheral corneal thickness values and anterior segment optic coherence tomography (AS-OCT) for obtaining central corneal epithelial thickness...
May 15, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29773881/evaluation-of-vascular-changes-with-optical-coherence-tomography-angiography-after-ruthenium-106-brachytherapy-of-circumscribed-choroidal-hemangioma
#7
Gilda Cennamo, Claudia Rossi, Maria Angelica Breve, Nunzio Velotti, Antonio Farella, Raffaele Liuzzi, Giovanni Cennamo
PURPOSE: To describe the vascular changes of circumscribed choroidal hemangioma (CCH) after ruthenium-106 brachytherapy using optical coherence tomography angiography (angio-OCT). METHODS: Seven eyes of 7 patients diagnosed with symptomatic CCH who underwent ruthenium-106 plaque radiotherapy were included in the study. Patients underwent complete ophthalmic examination, bulbar echography and angio-OCT. The same protocol was applied 1 year after ruthenium-106 brachytherapy...
May 18, 2018: Eye
https://www.readbyqxmd.com/read/29773466/in-vivo-morphologic-comparison-of-saphenous-vein-grafts-and-native-coronary-arteries-following-non-st-elevation-myocardial-infarction
#8
Tom Hsun-Wei Huang, Kalpa De Silva, Usaid K Allahwala, Edward J Danson, Pasi K Karjalainen, Olli A Kajander, Ravinay Bhindi
OBJECTIVE: This study aimed to assess the pathophysiological differences between saphenous vein grafts (SVG) and native coronary arteries (NCA) following presentation with non-ST elevated myocardial infarction (NSTEMI). BACKGROUND: There is accelerated pathogenesis of de novo coronary disease in harvested SVG following coronary artery bypass (CABG) surgery, which contributes to both early and late graft failure, and is also causal in adverse outcomes following vein graft PCI...
April 16, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29773326/tremelimumab-combined-with-durvalumab-in-patients-with-mesothelioma-nibit-meso-1-an-open-label-non-randomised-phase-2-study
#9
Luana Calabrò, Aldo Morra, Diana Giannarelli, Giovanni Amato, Armida D'Incecco, Alessia Covre, Arthur Lewis, Marlon C Rebelatto, Riccardo Danielli, Maresa Altomonte, Anna Maria Di Giacomo, Michele Maio
BACKGROUND: Tremelimumab, an anti-CTLA4 monoclonal antibody, initially showed good activity when used alone in patients with mesothelioma, but did not improve the overall survival of patients who failed on first-line or second-line chemotherapy compared with placebo in the DETERMINE study. We aimed to investigate the efficacy and safety of first-line or second-line tremelimumab combined with durvalumab, an anti-PD-L1 monoclonal antibody, in patients with malignant mesothelioma. METHODS: In this open-label, non-randomised, phase 2 trial, patients with unresectable pleural or peritoneal mesothelioma received intravenous tremelimumab (1 mg/kg bodyweight) and durvalumab (20 mg/kg bodyweight) every 4 weeks for four doses, followed by maintenance intravenous durvalumab at the same dose and schedule for nine doses...
May 14, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29772042/subfoveal-choroidal-thickness-as-a-potential-predictor-of-clinical-response-to-stereotactic-radiotherapy-for-neovascular-age-related-macular-degeneration
#10
Mahdy Ranjbar, Maximilian Kurz, Annekatrin Holzhey, Dirk Rades, Salvatore Grisanti
BACKGROUND AND OBJECTIVE: Stereotactic radiotherapy (SRT) is a new adjuvant treatment modality that has been shown to reduce the need for repetitive intravitreal injections (IVIs) in patients with neovascular age-related macular degeneration (nAMD). The authors aimed to determine baseline predictors of clinical response to SRT. PATIENTS AND METHODS: This was a retrospective, observational case series of patients with nAMD who underwent SRT and subsequently had at least 12 months of complete follow-up...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29770639/effect-of-cataract-grade-according-to-wide-field-fundus-images-on-measurement-of-macular-thickness-in-cataract-patients
#11
Mingue Kim, Youngsub Eom, Jong Suk Song, Hyo Myung Kim
PURPOSE: To investigate the effects of cataract grade based on wide-field fundus imaging on macular thickness measured by spectral domain optical coherence tomography (SD-OCT) and its signal-to-noise ratio (SNR). METHODS: Two hundred cataract patients (200 eyes) with preoperative measurements by wide-field fundus imaging and macular SD-OCT were enrolled. Cataract severity was graded from 1 to 4 according to the degree of macular obscuring by cataract artifact in fundus photo images...
May 15, 2018: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29770237/quantitative-measurement-of-peri-implant-bone-defects-using-optical-coherence-tomography
#12
Sulhee Kim, Se-Ryong Kang, Hee-Jung Park, Bome Kim, Tae-Il Kim, Won-Jin Yi
Purpose: The purpose of this study was to visualize and identify peri-implant bone defects in optical coherence tomography (OCT) images and to obtain quantitative measurements of the defect depth. Methods: Dehiscence defects were intentionally formed in porcine mandibles and implants were simultaneously placed without flap elevation. Only the threads of the fixture could be seen at the bone defect site in the OCT images, so the depth of the peri-implant bone defect could be measured through the length of the visible threads...
April 2018: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29769164/the-effectiveness-of-excimer-laser-angioplasty-to-treat-coronary-in-stent-restenosis-with-peri-stent-calcium-as-assessed-by-optical-coherence-tomography
#13
Tetsumin Lee, Richard A Shlofmitz, Lei Song, Theofanis Tsiamtsiouris, Thomas Pappas, Antonio Madrid, Allen Jeremias, Elizabeth S Haag, Ziad A Ali, Jeffery W Moses, Mitsuaki Matsumura, Gary S Mintz, Akiko Maehara
AIMS: We evaluated the effectiveness of excimer laser coronary angioplasty (ELCA) to treat in-stent restenosis (ISR) due to peri-stent calcium-related stent under-expansion as assessed by optical coherence tomography (OCT). METHODS AND RESULTS: We studied 81 patients (81 lesions with ISR, stent under-expansion, and peri-stent calcium >90°) who underwent OCT imaging both pre- and post-percutaneous coronary intervention and compared lesions treated with ELCA (n=23) vs without ELCA (n=58)...
May 15, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29765959/outcome-of-5-year-treatment-of-neovascular-age-related-macular-degeneration-with-intravitreal-anti-vegf-using-treat-and-extend-regimen
#14
Polona Jaki Mekjavic, Polona Zaletel Benda
Objective: The aim of this study is twofold. First , to evaluate the long-term outcome of anti-vascular endothelial growth factor (anti-VEGF) treatment in a clinical setting using the "treat-and-extend regimen" (TER) in patients with neovascular age-related macular degeneration (nAMD). Second , to determine the proportion of patients treated with anti-VEGF with good visual acuity (VA), i.e., vision sufficient to maintain a high level of independence. Design: We conducted a single center retrospective review of patients with treatment-naive nAMD who were treated with anti-VEGF...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29765081/new-birthweight-percentiles-by-sex-and-gestational-age-in-southern-china-and-its-comparison-with-the-intergrowth-21st-standard
#15
Fei Yao, Huazhang Miao, Bing Li, Yuntao Wu, Qingguo Zhao
We first showed the sex- and gestational age (week)-specific birthweight distributions from primiparous and multiparous mothers. Birthweight percentiles were created by using the Lambda Mu Sigma (LMS) method. We established the birthweight percentiles in Southern China and provide clinicians and researchers with up-to-date population norms of birthweight percentiles. Then we use the data from Birth Certificate System between Jan 1st, 2017 and Oct 31st, 2017, which included 1,245,364 live births to calculate SGA and LGA ratio by these three birthweight references- the new INTERGROWTH-21st standard, China's 2015 research standard and our birthweight percentiles...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29762561/wide-dynamic-range-high-speed-three-dimensional-quantitative-oct-angiography-with-a-hybrid-beam-scan
#16
Taejin Park, Sun-Joo Jang, Myounghee Han, Sukyoung Ryu, Wang-Yuhl Oh
We demonstrate a novel hybrid-beam scanning-based quantitative optical coherence tomography angiography (OCTA) that provides high-speed wide dynamic range blood flow speed imaging. The hybrid-beam scanning scheme enables multiple OCTA image acquisitions with a wide range of multiple time intervals simultaneously providing wide dynamic range blood flow speed imaging independent of the blood vessel orientation, which was quantified over a speed range of 0.6∼104  mm/s through the blood flow phantom experiments...
May 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29762268/influence-of-removing-the-large-retinal-vessels-related-effect-on-peripapillary-vessel-density-progression-analysis-in-glaucoma
#17
Gábor Holló
PURPOSE: To investigate the usefulness of removing the large vessel-related information from peripapillary optical coherence tomography (OCT) angiography progression analysis. Peripapillary vessel density (VD) image series which had shown no progression with an earlier software version that did not separate capillary and large vessel-related effects were reevaluated for selective peripapillary capillary VD progression. METHODS: Prospective retinal nerve fiber layer thickness (RNFLT) and peripapillary VD measurements were made using the Angiovue/RTvue-XR OCT on one eye of 9 normal, 20 under treatment ocular hypertensive (OHT) and 24 under treatment open-angle glaucoma patients at 6-month intervals for 2 years (5 visits)...
May 12, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29760981/a-handheld-microscope-integrating-photoacoustic-microscopy-and-optical-coherence-tomography
#18
Wei Qin, Qian Chen, Lei Xi
The combination of optical resolution photoacoustic microscopy (ORPAM) and optical coherence tomography (OCT) is capable of providing complementary imaging contrasts. Unfortunately, the miniaturization of ORPAM remains a major challenge in the development of a handheld dual-modality imaging microscope with OCT. Here, we report the design and evaluation of an integrated ORPAM and OCT imaging probe using a two-dimensional MEMS (micro-electro-mechanical-system)-based optical scanner. This microscope, weighting 35...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29760741/establishing-a-surgical-procedure-for-rhesus-epiretinal-scaffold-implantation-with-hipsc-derived-retinal-progenitors
#19
Ziming Luo, Kang Li, Kaijing Li, Bikun Xian, Ying Liu, Sijing Yang, Chaochao Xu, Zhigang Fan, Shoutao Lu, Haijun Zhang, Jian Ge
Background: To develop an effective surgical procedure for cellular scaffold epiretinal implantation in rhesus, facilitating subsequent epiretinal stem cell transplantation. Methods: Retinal progenitors were seeded onto a poly(lactic-co-glycolic) acid (PLGA) scaffold. First, the cellular scaffolds were delivered by 18G catheter or retinal forceps into rabbit epiretinal space ( n = 50). Then, the cell survival rate was evaluated by Cell Counting Kit-8 (CCK-8). Second, three methods of scaffold fixation, including adhesion after gas-liquid exchange ( n = 1), tamponade by hydrogel ( n = 1), and fixation by retinal tacks ( n = 4), were performed in rhesus monkeys...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29759670/systemic-octreotide-therapy-in-prevention-of-gastrointestinal-bleeds-related-to-arteriovenous-malformations-and-obscure-etiology-in-atrial-fibrillation
#20
Venkat Vuddanda, Mohammad-Ali Jazayeri, Mohit K Turagam, Madhav Lavu, Valay Parikh, Donita Atkins, Sudharani Bommana, Madhu Reddy Yeruva, Luigi Di Biase, Jie Cheng, Vijay Swarup, Rakesh Gopinathannair, Mojtaba Olyaee, Vijay Ivaturi, Andrea Natale, Dhanunjaya Lakkireddy
OBJECTIVES: The present study describes the use of octreotide (OCT) in patients with atrial fibrillation (AF) receiving oral anticoagulation (OAC) who have gastrointestinal (GI) bleeding related to arteriovenous malformations (AVMs), as well as its effect on OAC tolerance and subsequent rebleeding. BACKGROUND: AVMs cause significant GI bleeding, especially in patients with AF who are receiving OAC for stroke prevention. OCT has been shown to minimize recurrent GI bleeds related to AVMs...
December 11, 2017: JACC. Clinical Electrophysiology
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