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Dysphagia head neck tumors treatment

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https://www.readbyqxmd.com/read/30001987/pazopanib-plus-cetuximab-in-recurrent-or-metastatic-head-and-neck-squamous-cell-carcinoma-an-open-label-phase-1b-and-expansion-study
#1
Douglas Adkins, Paul Mehan, Jessica Ley, Marilyn J Siegel, Barry A Siegel, Farrokh Dehdashti, Xuntian Jiang, Noha N Salama, Kathryn Trinkaus, Peter Oppelt
BACKGROUND: Angiogenesis is a hallmark of head and neck squamous cell carcinoma (HNSCC), and a mechanism of resistance to EGFR inhibition. We investigated the safety and potential activity of pazopanib, an angiogenesis inhibitor, plus cetuximab, an EGFR inhibitor, in patients with recurrent or metastatic HNSCC. METHODS: We did an open-label, single-centre, dose-escalation phase 1b trial using a standard 3 + 3 design, followed by an expansion cohort phase. Eligible participants were patients with histologically or cytologically confirmed recurrent or metastatic HNSCC, aged at least 18 years, had measurable disease as per Response Evaluation Criteria in Solid Tumors (RECIST) version 1...
July 9, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29940683/undifferentiated-sarcoma-presenting-as-a-slowly-enlarging-facial-mass
#2
Alexis Lopez, Anton M Kushnaryov, Robert A Weisman
Head and neck sarcomas are rare and consist of a variety of histologic subtypes. We present a case of undifferentiated/unclassified sarcoma (UUS) of the maxillary sinus, a tumor subtype historically known as malignant fibrous histiocytoma (MFH) or undifferentiated pleomorphic sarcoma (UPS). A 50-year-old female patient presented with worsening facial pain and dysphagia. Physical examination demonstrated a large, ulcerated mass protruding from the oral cavity. Computed tomography demonstrated a large, enhancing mass centered in the right maxillary sinus with local invasion...
April 2018: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29868479/transoral-laser-microsurgery-for-supraglottic-cancer
#3
Petra Ambrosch, Mireia Gonzalez-Donate, Asita Fazel, Claudia Schmalz, Jürgen Hedderich
Introduction: Transoral laser microsurgery (TLM) is an accepted and effective treatment strategy for supraglottic carcinomas. Early supraglottic carcinoma has excellent outcomes independently of the treatment approach. The role of TLM for the treatment of locally advanced tumors is debated. Particularly, the functional outcomes after TLM have to be proven by functional assessment of large cohorts of patients. This study analyzes the oncologic and functional outcomes after TLM for supraglottic carcinomas...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29785183/evaluation-of-reirradiation-in-locally-advanced-head-and-neck-cancers-toxicity-and-early-clinical-outcomes
#4
Amit Bahl, Arun Singh Oinam, Arun Elangovan, Satinder Kaur, Gaurav Trivedi, Roshan Verma, Sudhir Bhandari, Sushmita Ghoshal, Naresh Kumar Panda
Objectives: Locoregional recurrence is the predominant pattern of treatment failure in advanced head and neck cancers. Reirradiation is a useful modality to treat inoperable head and neck cancer patients with recurrent disease. The aim of the present study was to analyze the treatment toxicity and early clinical outcomes in patients undergoing reirradiation. Methods: Twenty patients of head and neck cancers with recurrences or second cancers were evaluated. Reirradiation was done using simultaneous integrated boost volumetric modulated arc therapy (SIB VMAT), intensity modulated radiotherapy (IMRT), or conventional radiotherapy using 6MV photons...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29743120/cavernous-sinus-involvement-in-human-papillomavirus-associated-oropharyngeal-squamous-cell-carcinoma-case-report-of-an-atypical-site-of-distant-metastasis
#5
David Forner, Derek Wilke, Matthew H Rigby, Sidney Croul, Anuradha Mishra, Emad Massoud, David B Clarke, Nathan Lamond
BACKGROUND: HPV-associated OSCC (HPV-OSCC) has been determined to be a distinct disease entity from non-HPV associated OSCC. Patients affected by HPV-OSCC generally have a more favourable prognosis, with improved rates of locoregional control and survival compared with their non-HPV counterparts. Despite this, HPV-OSCC has a similar rate of distant metastases. Interestingly, recent evidence has emerged that demonstrates more frequent atypical metastasis patterns when compared to non-HPV associated disease...
May 9, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29652817/selenium-in-radiation-oncology-15-years-of-experiences-in-germany
#6
REVIEW
Ralph Muecke, Oliver Micke, Lutz Schomburg, Jens Buentzel, Klaus Kisters, Irenaeus A Adamietz
Introduction: Se measurement and supplementation in radiation oncology is a controversial issue. The German Working Group Trace Elements and Electrolytes in Oncology (AKTE) has conducted a number of studies on this issue, which are summarized in this review. Strategies have been tested and developed, aiming to stratify the patients with a potential need for supplemental Se and how best to monitor Se supplementation with respect to health effects and risks. Methods: We analyzed blood and tissue Se-levels of different tumor patients ( n = 512)...
April 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29556677/a-feasibility-study-on-adaptive-18-f-fdg-pet-guided-radiotherapy-for-recurrent-and-second-primary-head-and-neck-cancer-in-the-previously-irradiated-territory
#7
Julie Schatteman, Dirk Van Gestel, Dieter Berwouts, Werner De Gersem, Geert De Kerf, Wilfried De Neve, Bie De Ost, Ana Maria Luiza Olteanu, Sylvie Rottey, Tom Vercauteren, Ingeborg Goethals, Fréderic Duprez
PURPOSE: To evaluate feasibility, disease control, survival, and toxicity after adaptive 18 F-fluorodeoxyglucose (FDG) positron emisson tomography (PET) guided radiotherapy in patients with recurrent and second primary head and neck squamous cell carcinoma. METHODS: A prospective trial investigated the feasibility of adaptive intensity modulated radiotherapy (IMRT) ± concomitant cetuximab in 10 patients. The primary endpoint was achieving a 2-year survival free of grade >3 toxicity in ≥30% of patients...
August 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29447817/mature-and-immature-pediatric-head-and-neck-teratomas-a-15-year-review-at-a-large-tertiary-center
#8
Harish Dharmarajan, Noémie Rouillard-Bazinet, Binoy M Chandy
INTRODUCTION: Pediatric head and neck teratomas account for less than 4% of congenital teratomas. The distinct presentations and outcomes of mature and immature head and neck teratomas have not been well established. OBJECTIVES: To review the management and outcomes of pediatric head and neck teratomas. To distinguish differences between mature and immature tumors with respect to the age at presentation and surgery, tumor size and location, alpha fetoprotein (AFP) levels, airway management, and recurrence...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29404691/interdisciplinary-telemedicine-in-the-management-of-dysphagia-in-head-and-neck
#9
Mydhili Mayadevi, Krishnakumar Thankappan, Shashikant Vishnubhai Limbachiya, Sivakumar Vidhyadharan, Brenda Villegas, Melody Ouyoung, Deepak Balasubramanian, Jayakumar R Menon, Uttam Sinha, Subramania Iyer
The study considered the feasibility and impact of interdisciplinary telemedicine discussions in the management of post-treatment dysphagia in patients with head and neck tumors. This is a retrospective analysis of patients with persistent dysphagia after treatment for head and neck pathology, at an institute in India. The cases were discussed in the telemedicine meeting conducted between host institute and a second unit in the United States. A monthly meeting was organized, using an internet-based video conference system...
August 2018: Dysphagia
https://www.readbyqxmd.com/read/29377087/clinical-features-and-management-of-schwannoma-affecting-the-upper-and-lower-lips
#10
REVIEW
Jenna Sitenga, Gregory Aird, Adam Vaudreuil, Christopher J Huerter
Head and neck schwannomas comprise 25-40% of all schwannomas, with presentation on the lips as the rarest and most surgically complicated site for perioral tumors. A systematic literature review was conducted to include 21 cases of patients with schwannoma of the upper or lower lips. The majority of patients presented with a single, painless, well-encapsulated nodule on the upper or lower lips. The nodules were consistently slow-growing, with an average 29.3 months from symptom onset to clinical presentation...
January 29, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29299514/percutaneous-gastrostomy-site-metastasis-from-head-and-neck-tumors-a-single-institution-case-series
#11
James S Metkus, David Cognetti, Joseph Curry
Objectives: Head and neck cancer (HNC) patients often require percutaneous gastrostomy (PEG) tube placement due to malnutrition and dysphagia. While beneficial, PEG tube placement can cause a rare but reportable complication of metastasis of the original tumor to the gastrostomy exit site. The objectives of this case series were to present HNC patients at a single institution that developed PEG tube metastases, their subsequent treatment, and review of the literature for similar cases...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29250693/non-hodgkin-s-lymphoma-rare-localization-at-the-base-of-the-tongue-case-presentation
#12
Daniel Mirea, Liliana Elena Mirea, Cornelia Nitipir, Mirela Ţigliş, Ioana Cristina GrinŢescu, Tiberiu Paul Neagu, Carmen Aurelia Mogoantă, Ioana Marina GrinŢescu
The extranodal malignant lymphomas occur mainly in the region of the head and neck, after the gastrointestinal tract. The most common site of the head and neck lymphoma is at the lymphatics ring of Waldeyer, followed by the nasosinusal region. Localization at the base of the tongue is extremely rare. The authors reported a case of a 50-year-old male with a non-Hodgkin's lymphoma, which developed at the base of tongue. An unusual sensation described as a foreign body at the hypopharyngeal region associated with progressive dysphagia were the main symptoms for which the patient was referred to our Hospital...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29075740/long-term-functional-and-quality-of-life-outcomes-after-transoral-robotic-surgery-in-patients-with-oropharyngeal-cancer
#13
Virginie Achim, Rachel K Bolognone, Andrew D Palmer, Donna J Graville, Tyler J Light, Ryan Li, Neil Gross, Peter E Andersen, Daniel Clayburgh
Importance: In recent years, transoral robotic surgery (TORS) has emerged as a useful treatment for oropharyngeal squamous cell carcinoma (OPSCC). In appropriately selected patients, the use of TORS may allow avoidance of adjuvant chemotherapy and/or radiotherapy, thereby avoiding the long-term adverse effects of these therapies. Objective: To compare functional speech, swallowing, and quality-of-life outcomes longitudinally between those undergoing TORS only and those undergoing TORS and adjuvant radiotherapy (TORS+RT) or TORS and chemoradiotherapy (TORS+CRT)...
October 26, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29018506/clinical-features-and-surgical-treatment-of-schwannoma-affecting-the-base-of-the-tongue-a-systematic-review
#14
REVIEW
Jenna Lamendola Sitenga, Gregory Alan Aird, Austin Nguyen, Adam Vaudreuil, Christopher Huerter
Introduction  Schwannomas of the head and neck account for 25-40% of all cases, with presentation at the base of the tongue as the most frequent site for intraoral tumors. Objectives  Here, a systematic review was conducted to include 15 cases of patients with schwannoma of the base of the tongue. Data Synthesis  Most patients presented with a single, painless, well-encapsulated nodule at the base of the tongue. These nodules were slow-growing, with an average of 13.3 months from onset to presentation...
October 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28887707/correlations-between-patient-reported-dysphagia-screening-and-penetration-aspiration-scores-in-head-and-neck-cancer-patients-post-oncological-treatment
#15
Johanna Hedström, Lisa Tuomi, Caterina Finizia, Caroline Olsson
Dysphagia is a common and severe toxicity after oncological treatment of head and neck cancer (HNC). The study aim was to investigate relationships between patient-reported dysphagia and clinically measured swallowing function in HNC after modern curative radiotherapy with or without chemotherapy to identify possible alarm symptoms for clinically manifest dysphagia. Patients with tumors of the tonsil, base of tongue, hypopharynx, and larynx treated in 2007-2015 were assessed for dysphagia post-treatment by telephone interview and videofluoroscopy (VFS)...
April 2018: Dysphagia
https://www.readbyqxmd.com/read/28518591/su-e-t-301-evaluation-of-simultaneously-integrated-boost-sib-and-sequential-imrt-boost-sqib-treatments-of-head-and-neck-cancer-using-empirical-radiobiological-modeling
#16
G Narayanasamy, S Jang, A Pyakuryal, I Bacchus, A Perez-Andujar, T Sio, M Kudrimoti
PURPOSE: To evaluate and compare normal tissue complication probabilities (NTCP) in SIB (simultaneous integrated boost) and SqIB (sequential IMRT boost) IMRT methods in head and neck cancer using the radiobiological modeling of HART program (Histogram Analysis in Radiation Therapy; J Appl Clin Med Phys 11(1): 3013, 2010). METHODS: Of the 40 SIB IMRT cases identified in a 2-year follow up study, 14 SIB (Rx range: 66-70Gy) cases that developed dysphagia(N=11) or xerostomia(N=10) or both types of complications(N=9) were studied...
June 2013: Medical Physics
https://www.readbyqxmd.com/read/28376853/a-large-giant-cell-tumor-of-the-larynx-case-report-and-review-of-the-literature
#17
REVIEW
Andrew Arndt, Rachelle LeBlanc, Peter Spafford
BACKGROUND: Giant cell tumors (GCTs) are typically found in the metaphyseal-epiphyseal area of long bones but can also occur in the head and neck region. GCT of the larynx is a rare entity with only 42 reported cases in the international literature. Furthermore, to the best of our knowledge this is the largest laryngeal GCT reported in the literature to date. GCT of the larynx can present with dysphonia, dyspnea, and/or dysphagia and should be considered in the differential diagnosis of a neck mass...
April 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28327089/uniform-fdg-pet-guided-gradient-dose-prescription-to-reduce-late-radiation-toxicity-upgrade-rt-study-protocol-for-a-randomized-clinical-trial-with-dose-reduction-to-the-elective-neck-in-head-and-neck-squamous-cell-carcinoma
#18
RANDOMIZED CONTROLLED TRIAL
Sven van den Bosch, Tim Dijkema, Martina C Kunze-Busch, Chris H J Terhaard, Cornelis P J Raaijmakers, Patricia A H Doornaert, Frank J P Hoebers, Marije R Vergeer, Bas Kreike, Oda B Wijers, Wim J G Oyen, Johannes H A M Kaanders
BACKGROUND: In definitive radiation therapy for head and neck cancer, clinically uninvolved cervical lymph nodes are irradiated with a so-called 'elective dose' in order to achieve control of clinically occult metastases. As a consequence of high-resolution diagnostic imaging, occult tumor volume has significantly decreased in the last decades. Since the elective dose is dependent on occult tumor volume, the currently used elective dose may be higher than necessary. Because bilateral irradiation of the neck contributes to dysphagia, xerostomia and hypothyroidism in a dose dependent way, dose de-escalation to these regions can open a window of opportunity to reduce toxicity and improve quality of life after treatment...
March 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28300950/correlation-between-swallowing-related-quality-of-life-and-videofluoroscopy-after-head-and-neck-cancer-treatment
#19
Margareth Souza Andrade, Aline Nogueira Gonçalves, Renata Lígia Vieira Guedes, Camila Barbosa Barcelos, Luciana Dall'Agnol Siqueira Slobodticov, Simone Aparecida Claudino Lopes, Ana Lúcia Noronha Francisco, Elisabete Carrara de Angelis
Introduction: The use of symptom-specific questionnaires on head and neck cancer (HNC), together with objective swallowing measures, can be sensitive to changes in quality of life (QoL) resulting from dysphagia, but this tool is not broadly used as a complement to clinical evaluations. Purpose: To analyze the correlation between the M. D. Anderson Dysphagia Inventory (MDADI) questionnaire and videofluoroscopy (VF) in patients treated for head and neck cancer. Methods: This is a retrospective study with review of clinical data, VF and MDADI results...
March 9, 2017: CoDAS
https://www.readbyqxmd.com/read/27757479/-diagnosis-and-treatment-of-parapharyngeal-space-tumors
#20
REVIEW
F Bootz, S Greschus, T van Bremen
The parapharyngeal space extends from the nasopharynx to the oropharynx. It is bordered medially by the pharyngeal wall and the constrictor pharyngis muscles, and laterally by the mandible. One distinguishes between a pre- and a poststyloid space. Tumors of the parapharyngeal space are rare and represent less than 1 % of all head and neck neoplasms. Benign (70-80 %) as well as malignant (20-30 %) tumors arise from different structures of the parapharyngeal space, mainly from salivary glands and nerve structures...
November 2016: HNO
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